CN100435858C - The composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose and its preparation method - Google Patents
The composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose and its preparation method Download PDFInfo
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- CN100435858C CN100435858C CNB2006101228650A CN200610122865A CN100435858C CN 100435858 C CN100435858 C CN 100435858C CN B2006101228650 A CNB2006101228650 A CN B2006101228650A CN 200610122865 A CN200610122865 A CN 200610122865A CN 100435858 C CN100435858 C CN 100435858C
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Abstract
An alginate-carboxymethyl cellulose compound skeleton adhesive and its preparation method, used for bonding repair of human hard tissue, especially relates to compound skeleton adhesive and its preparation method use sodium alginate and sodium carboxymethyl cellulose as materials. The invention provides an easy, high bonding strength, rapidly solidified, biocompatible preparation method of alginate-carboxymethyl cellulose and compound skeleton adhesive. Its compositions and percentages by weight are: alginate: 1 to10 percent; carboxymethyl cellulose sodium: 1 to10 percent; calcium agent : 0 to 50 percent total weight of sodium alginate and sodium carboxymethyl cellulose; the remaining component is water. The preparation steps are: add the said raw materials in certain proportions into the water mix well, and the tremellose alginate-carboxymethyl cellulose compound skeleton adhesive was obtained.
Description
Technical field
The present invention relates to a kind of binding agent that the human body hard tissue bonding is repaired that is used for, especially relating to a kind of is composite skeletal agglutinant made of material and preparation method thereof with sodium alginate and sodium carboxymethyl cellulose.
Background technology
Along with the development of the vehicles, people are subjected to the high-energy damage and cause the comminuted fracture of limbs increasing, and comminuted fracture does not also have good Therapeutic Method at present, often resets because of too little being difficult to of osteomiosis piece.Screw, Kirschner wire are fixing may to be made fragment split to become littler and can't fix if use, and the para-position that causes fracturing bad (especially intraarticular comminuted fracture) finally causes sequela such as limbs disturbance.
Adopting adhesive of medical that the osteomiosis piece is carried out bonding resetting is more promising at present a kind of Therapeutic Method.Ideal adhesive of medical should possess following character: 1, safety, reliable, avirulence, nothing three cause (carcinogenic, teratogenesis, mutagenesis); 2, have excellent biological compatibility, do not hinder self healing of tissue; 3, aseptic and can keep aseptic over a period to come; 4, under the condition that blood and tissue fluid are arranged, can use; 5, under room temperature, normal pressure, can realize quick-binding; 6, have good adhesive strength and persistency, stick portion has certain elasticity and toughness; 7, in use to the tissue nonirritant; 8, reach can degrade gradually after the result of use, absorption, metabolism; 9, has good user mode and be easy to preserve.Yet present skeletal agglutinant is mainly the modified model of bone cement or based on phosphatic composition, generally more or less all there are some defectives in the adhesive of medical of Shi Yonging.As a-cyanoacrylate class binding agent, though binding speed is fast, glue-line fragility is big, bonding strength is not high, can produce deleterious formaldehyde during decomposition; Fibrin class adhesive, adhesive strength is lower, is again Blood Preparations, is not easy to be accepted by patient; Even special orthopaedics adhesive bone cement also can produce deleterious monomer in adhesion process, and between bone, form thicker conjunctive tissue film easily, make bonding insecure.
Alginic acid is the polysaccharide material that refines from seaweed plants, and it is widely used aspect medical.(Ma Ping such as Ma Ping, Zhu Li, Sun Shuying etc. the preparation of calcium alginate gel bead and pH dependency swelling [J]. Chinese marine drug, 2003,5 (22): 35-37) utilize sodium alginate soln and calcium chloride solution generation gelling reaction, method with the system of dripping has prepared calcium alginate gel bead, has investigated the feature and the swelling character of calcium alginate gel bead simultaneously; And further with ca alginate gel bead as the oral sustained release drug administration carrier, find that the release of medicine from micropill is with diffusion and the molten mode that dies and combine of skeleton, think that thus ca alginate gel bead has the suitable property (Ma Ping of good slow release, Zhu Li, Sun Shuying etc. ca alginate gel bead is as the research [J] of oral sustained release drug administration carrier. Shenyang Pharmaceutical University's journal, 2001,6:406-408).Xiang Chuan etc. are (to the river, Jiang Changming, Du Jingyuan etc. the experimentation [J] of osteoblast biocompatibility in polylactic acid and calcium alginate. Chinese Chinese and western medicine magazine, 2002,3 (15): 1345-1347) will find after osteocyte and polylactic acid, the calcium alginate compounded cultivation, the calcium alginate cell growth has certain promotion, and thinks that polylactic acid and calcium alginate all have excellent biological compatibility, and the biocompatibility of calcium alginate is better than polylactic acid.(Li Guanghui such as Li Guanghui, Xia Renyun, Chen Chao. the research of the compound repairing bone defect of marrow stromal cell/alginate jelly [J]. Chinese experimental surgery magazine, 2003,11 (20): 1031-1032) that the marrow stromal cell (BMSCS) of In vitro culture is compound with alginate jelly, experiment thinks that BMSCS/ alginate jelly complex has the effect of obvious promotion bone defect repair.(Min Shaoxiong such as Min Shaoxiong, Jin Anmin, Zhu Lixin etc. novel poly-DL-lactic acid/calcium alginate packing material is repaired the damaged experimentation [J] of long bone. Chinese clinical rehabilitation, 2003,7 (26), 3540-3542) calcium alginate (CAG) gel and poly-DL-lactic acid (PDLLA) are made the three-dimensional porous material of same apertures, damaged rabbit grouping compares test to bone, description of test PDLLA/CAG composite has excellent biological compatibility and absorbability, the adding of CAG has promoted the bone conduction ability of porous PDLLA in the bone defect repair, improved osteogenetic quality, PDLLA/CAG is a kind of bone grafting material that potential applicability in clinical practice is arranged.(Gu Genghua such as Gu Genghua, He Hong, Huang Jianqi. the calcium alginate film guiding regenerated controlled trial of rabbit jaw defect [J]. modern stomatology magazine, 2002,5 (16)-: studies show that 388-390), (calcium alginate film CAF) as the absorbable biological film, has good guiding osteanagenesis usefulness to the calcium alginate film preparation.Chen Zida etc. (Chen Zida, Li Ling, Zou's writing brush. the progress of medical adhesive [J]. chemical and bonding, 2001,1:21) then the progress of current medical adhesive has been done more comprehensive introduction.
Above-mentioned research report shows that all alginate is having application promise in clinical practice aspect the medical bone treatment, but the relevant research that with the sodium alginate is main gel as osteomiosis piece broken ends of fractured bone binding agent there is no report both at home and abroad.
Summary of the invention
The objective of the invention is at problems such as the existing glue-line fragility of existing adhesive of medical especially skeletal agglutinant is big, bonding strength is not high, toxic side effects, provide a kind of and have preparation easily, the adhesion strength height, solidify rapidly composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose of advantages such as good biocompatibility and preparation method thereof.
For achieving the above object, technical scheme of the present invention is to adopt the stock of natural alginate as skeletal agglutinant.
The composition of composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose of the present invention and content by mass percentage thereof are:
Sodium alginate: 1%～10%;
Sodium carboxymethyl cellulose: 1%～10%;
Calsium supplement: 0%～50% of sodium alginate and sodium carboxymethyl cellulose gross mass;
All the other compositions are water.
Described calsium supplement is a kind of in calcium alginate, calcium phosphate, the calcium carbonate or their mixture.
Its step of the preparation method of composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose of the present invention is as follows:
Above-mentioned each raw material is added in the entry in proportion, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Compare with existing skeletal agglutinant, outstanding advantage of the present invention is that with the stock of medical high polymer viscose glues such as sodium alginate and sodium carboxymethyl cellulose as skeletal agglutinant, preparation technology is simple, with low cost; Characteristics such as the binding agent of preparing not only has safety preferably and biocompatibility, and it is higher also to have adhesion strength, solidifies rapidly, and is easy to operate; Add the calsium supplement that promotes bone healing simultaneously, helped the quickly-healing of skeleton.
The specific embodiment
Embodiment 1
Raw materials such as sodium alginate 1g, sodium carboxymethyl cellulose 3g and calsium supplement calcium alginate 1g are added in the 95g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Embodiment 2
Raw materials such as sodium alginate 2g, sodium carboxymethyl cellulose 5g and calsium supplement calcium alginate 0.7g are added in the 92.3g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Embodiment 3
Raw materials such as sodium alginate 3g, sodium carboxymethyl cellulose 1g and calsium supplement calcium carbonate 2g are added in the 94g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Embodiment 4
Raw materials such as sodium alginate 4g, sodium carboxymethyl cellulose 10g and calsium supplement calcium phosphate 5g are added in the 81g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Embodiment 5
Raw materials such as sodium alginate 5g, sodium carboxymethyl cellulose 8g and calsium supplement calcium alginate 1.5g and calcium phosphate 1g are added in the 84.5g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Embodiment 6
Raw materials such as sodium alginate 6g, sodium carboxymethyl cellulose 2g and calsium supplement calcium alginate 1.5g and calcium carbonate 1g are added in the 89.5g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Embodiment 7
Sodium alginate 7g and sodium carboxymethyl cellulose 4g raw material are added in the 89g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Embodiment 8
Raw materials such as sodium alginate 8g, sodium carboxymethyl cellulose 6g and calsium supplement calcium alginate 2g, calcium phosphate 1.5g and calcium carbonate 1.5g are added in the 81g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Embodiment 9
Raw materials such as sodium alginate 9g, sodium carboxymethyl cellulose 9g and calsium supplement calcium phosphate 1.5g and calcium carbonate 1.2g are added in the 79.3g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Embodiment 10
Raw materials such as sodium alginate 10g, sodium carboxymethyl cellulose 7g and calsium supplement calcium alginate 3g, calcium phosphate 2.5g and calcium carbonate 2g are added in the 75.5g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Claims (2)
1. composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose is characterized in that its composition and content by mass percentage thereof are:
Sodium alginate: 1%～10%;
Sodium carboxymethyl cellulose: 1%～10%;
Calsium supplement: 0%～50% of sodium alginate and sodium carboxymethyl cellulose gross mass, calsium supplement are a kind of in calcium alginate, calcium phosphate, the calcium carbonate or their mixture;
All the other compositions are water.
2. the preparation method of composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose as claimed in claim 1 is characterized in that its step is as follows:
Each raw material is added in the entry in proportion, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
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| CN100435858C true CN100435858C (en) | 2008-11-26 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103041442A (en) * | 2013-01-23 | 2013-04-17 | 厦门大学 | Sodium alginate-based bone binding agent and preparation method thereof |
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| CN100500227C (en) * | 2006-10-23 | 2009-06-17 | 厦门大学 | Skeletal agglutinant conglutinating method |
| CN101632839B (en) * | 2008-07-22 | 2012-11-14 | 集美大学 | Novel bone binding material and preparation method thereof |
| US9549760B2 (en) * | 2010-10-29 | 2017-01-24 | Kyphon Sarl | Reduced extravasation of bone cement |
| CN102406962A (en) * | 2011-11-25 | 2012-04-11 | 集美大学 | Chondroitin sulfate-polyethylene glycol combined bone cement and its preparation method |
| CN103936881B (en) * | 2013-04-24 | 2018-06-19 | 广州噢斯荣医药技术有限公司 | A kind of preparation method of the drug of promoting bone growing protein expression accelerating union of bone fracture |
| CN105920657B (en) * | 2014-11-07 | 2019-04-30 | 稳健医疗(嘉鱼)有限公司 | A kind of preparation method of the adhesive of medical using medical macromolecular materials |
| CN105018023B (en) * | 2015-07-03 | 2017-09-15 | 南京财经大学 | A kind of medical adhesive |
| CN115804861B (en) * | 2021-09-14 | 2024-06-14 | 北京纳通医学研究院有限公司 | Bone adhesive solid phase composition and bone adhesive |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2322864A (en) * | 1997-03-07 | 1998-09-09 | Polybiomed Ltd | Gel for application to the human or animal body |
| JP2001049199A (en) * | 1999-05-31 | 2001-02-20 | Kuraray Co Ltd | Adhesive composition and its production |
| CN1307908A (en) * | 2001-02-22 | 2001-08-15 | 华东理工大学 | Inorganic bane adhesive and its application in body's hard tissue repair |
| CN1313739A (en) * | 1998-08-18 | 2001-09-19 | 拜奥迈特科学公司 | Adhesive compositions for the hard tissues of the human body |
| EP1364663A1 (en) * | 2002-05-21 | 2003-11-26 | Commonwealth Scientific And Industrial Research Organisation | Ocular devices with functionalized surface with adhesive properties |
| CN1943798A (en) * | 2006-10-23 | 2007-04-11 | 厦门大学 | Skeletal agglutinant and its conglutinating method |
-
2006
- 2006-10-23 CN CNB2006101228650A patent/CN100435858C/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2322864A (en) * | 1997-03-07 | 1998-09-09 | Polybiomed Ltd | Gel for application to the human or animal body |
| CN1313739A (en) * | 1998-08-18 | 2001-09-19 | 拜奥迈特科学公司 | Adhesive compositions for the hard tissues of the human body |
| JP2001049199A (en) * | 1999-05-31 | 2001-02-20 | Kuraray Co Ltd | Adhesive composition and its production |
| CN1307908A (en) * | 2001-02-22 | 2001-08-15 | 华东理工大学 | Inorganic bane adhesive and its application in body's hard tissue repair |
| EP1364663A1 (en) * | 2002-05-21 | 2003-11-26 | Commonwealth Scientific And Industrial Research Organisation | Ocular devices with functionalized surface with adhesive properties |
| CN1943798A (en) * | 2006-10-23 | 2007-04-11 | 厦门大学 | Skeletal agglutinant and its conglutinating method |
Non-Patent Citations (4)
| Title |
|---|
| 壳聚糖海藻酸钠微球与骨髓基质细胞相容性实验研究. 覃昱，裴国献，谢德明，金丹，魏宽海.中国矫形外科杂志，第11卷第13期. 2003 |
| 壳聚糖海藻酸钠微球与骨髓基质细胞相容性实验研究. 覃昱，裴国献，谢德明，金丹，魏宽海.中国矫形外科杂志，第11卷第13期. 2003 * |
| 琼脂－羧甲基纤维素粘性的研究及应用. 黄民，冯伟民.食品科学，第总164期. 1993 |
| 琼脂－羧甲基纤维素粘性的研究及应用. 黄民，冯伟民.食品科学，第总164期. 1993 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103041442A (en) * | 2013-01-23 | 2013-04-17 | 厦门大学 | Sodium alginate-based bone binding agent and preparation method thereof |
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