CN1943798A - Skeletal agglutinant and its conglutinating method - Google Patents
Skeletal agglutinant and its conglutinating method Download PDFInfo
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- CN1943798A CN1943798A CN 200610122873 CN200610122873A CN1943798A CN 1943798 A CN1943798 A CN 1943798A CN 200610122873 CN200610122873 CN 200610122873 CN 200610122873 A CN200610122873 A CN 200610122873A CN 1943798 A CN1943798 A CN 1943798A
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Abstract
A skeleton adhesive used for bonding repair of human hard tissue especially two kind compound skeleton adhesive and its bonding method to the skeleton, particularly the bonding method to the comminuted fracture. The preparation provides easy, high bond strength, rapidly solidified, biocompatible skeleton adhesive, its preparation method and bonding method. Its compositions and percentages by weight are : sodium alginate : 1 to10 percent; enhance colloid : 1 to10 percent; calcium supplements : 0 to 50 percent overall quality of sodium alginate and guar gum ; the remaining components is water. When bonding, the bonding skeleton must be soaked in sodium alginate solutions, and then soaked in calcium chloride solutions. cover the surface layer of broken bones with calcium alginate membrane, then daub, embed ,bond with skeleton adhesive, the bonding skeleton was then immersed in calcium chloride solutions again, and the solidification to bonding skeleton will be achieved.
Description
Technical field
The present invention relates to a kind of particularly binding agent of repairing of skeleton bonding of human body hard tissue that is used for, especially relate to two kinds of composite skeletal agglutinant mades and to the adhesive bonding method of skeleton, particularly at the broken bone adhesive bonding method in the comminuted fracture.
Background technology
Development along with the vehicles, people are subjected to the high-energy damage and cause the comminuted fracture of limbs increasing, and comminuted fracture does not also have good Therapeutic Method at present, often reset because of too little being difficult to of osteomiosis piece, if using screw, Kirschner wire fixes, fragment is split become littler and can't fix, the para-position that causes fracturing bad (especially intraarticular comminuted fracture) finally causes sequela such as limbs disturbance.
Adopting adhesive of medical that the osteomiosis piece is carried out bonding resetting is more promising at present a kind of Therapeutic Method.Ideal adhesive of medical should possess following character: 1, safety, reliable, avirulence and nothing three cause (carcinogenic, teratogenesis, mutagenesis); 2, have excellent biological compatibility, do not hinder self healing of tissue; 3, aseptic, and can keep aseptic over a period to come; 4, under the condition that blood and tissue fluid are arranged, can use; 5, under room temperature and normal pressure, can realize quick-binding; 6, have good adhesive strength and persistency, stick portion has certain elasticity and toughness; 7, in use to the tissue nonirritant; 8, reach can degrade gradually after the result of use, absorption and metabolism; 9, has good user mode and be easy to preserve.Yet present skeletal agglutinant is mainly the modified model of bone cement or based on phosphatic composition, generally more or less all there are some defectives in the adhesive of medical of Shi Yonging.As a-cyanoacrylate class binding agent, though binding speed is fast, glue-line fragility is big, bonding strength is not high, can produce deleterious formaldehyde during decomposition; Fibrin class adhesive, adhesive strength is lower, is again Blood Preparations, is not easy to be accepted by patient; Even special orthopaedics adhesive bone cement also can produce deleterious monomer in adhesion process, and between bone, form thicker conjunctive tissue film easily, make bonding insecure.
Alginic acid is the polysaccharide material that refines from seaweed plants, and it is widely used aspect medical.(Ma Ping such as Ma Ping, Zhu Li, Sun Shuying etc. the preparation of calcium alginate gel bead and pH dependency swelling [J]. Chinese marine drug, 2003,5 (22): 35-37) utilize sodium alginate soln and calcium chloride solution generation gelling reaction, method with the system of dripping has prepared calcium alginate gel bead, has investigated the feature and the swelling character of calcium alginate gel bead simultaneously; And further with ca alginate gel bead as the oral sustained release drug administration carrier, find that the release of medicine from micropill is with diffusion and the molten mode that dies and combine of skeleton, think that thus ca alginate gel bead has the suitable property (Ma Ping of good slow release, Zhu Li, Sun Shuying etc. ca alginate gel bead is as the research [J] of oral sustained release drug administration carrier. Shenyang Pharmaceutical University's journal, 2001,6:406-408).Xiang Chuan etc. are (to the river, Jiang Changming, Du Jingyuan etc. the experimentation [J] of osteoblast biocompatibility in polylactic acid and calcium alginate. Chinese Chinese and western medicine magazine, 2002,3 (15): 1345-1347) will find after osteocyte and polylactic acid, the calcium alginate compounded cultivation, the calcium alginate cell growth has certain promotion, and thinks that polylactic acid and calcium alginate all have excellent biological compatibility, and the biocompatibility of calcium alginate is better than polylactic acid.(Li Guanghui such as Li Guanghui, Xia Renyun, Chen Chao. the research of the compound repairing bone defect of marrow stromal cell/alginate jelly [J]. Chinese experimental surgery magazine, 2003,11 (20): 1031-1032) that the marrow stromal cell (BMSCS) of In vitro culture is compound with alginate jelly, experiment thinks that BMSCS/ alginate jelly complex has the effect of obvious promotion bone defect repair.(Min Shaoxiong such as Min Shaoxiong, Jin Anmin, Zhu Lixin etc. novel poly-DL-lactic acid/calcium alginate packing material is repaired the damaged experimentation [J] of long bone. Chinese clinical rehabilitation, 2003,7 (26), 3540-3542) calcium alginate (CAG) gel and poly-DL-lactic acid (PDLLA) are made the three-dimensional porous material of same apertures, damaged rabbit grouping compares test to bone, description of test PDLLA/CAG composite has excellent biological compatibility and absorbability, how the adding of CAG has promoted the bone conduction ability of PDLLA in the bone defect repair, improved osteogenetic quality, PDLLA/CAG is a kind of bone grafting material that potential applicability in clinical practice is arranged.(Gu Genghua such as Gu Genghua, He Hong, Huang Jianqi. the calcium alginate film guiding regenerated controlled trial of rabbit jaw defect [J]. modern stomatology magazine, 2002,5 (16): studies show that 388-390), (calcium alginate film CAF) as the absorbable biological film, has good guiding osteanagenesis usefulness to the calcium alginate film preparation.Chen Zida etc. (Chen Zida, Li Ling, Zou's writing brush. the progress of medical adhesive [J]. chemical and bonding, 2001,1:21) then the progress of current medical adhesive has been done more comprehensive introduction.
Above-mentioned research report shows that all alginate is having application promise in clinical practice aspect the medical bone treatment, but the relevant research that with the sodium alginate is main gel as osteomiosis piece broken ends of fractured bone binding agent there is no report both at home and abroad.
Summary of the invention
The objective of the invention is to some defectives at existing skeletal agglutinant existence, provide a kind of and have preparation easily, the adhesion strength height solidifies rapidly skeletal agglutinant of advantages such as good biocompatibility and preparation method thereof.
Another object of the present invention is to provide a kind of adhesive bonding method that utilizes above-mentioned skeletal agglutinant to skeleton.
Technical scheme of the present invention is to adopt sodium alginate and strengthen the stock of colloid as skeletal agglutinant.
Its composition of skeletal agglutinant of the present invention and content by mass percentage are:
Sodium alginate: 1%～10%;
Strengthen colloid: 1%～10%;
Calsium supplement: 0%～50% of sodium alginate and melon glue gross mass;
All the other compositions are water.
Described reinforcement colloid is sodium carboxymethyl cellulose or melon glue.
Described calsium supplement is a kind of in calcium alginate, calcium phosphate, the calcium carbonate or their mixture.
The preparation method of described skeletal agglutinant is to add mentioned component in the entry in proportion, mixing and stirring, promptly obtain gelationus composite skeletal agglutinant made, be respectively composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose (strengthen colloid and adopt sodium carboxymethyl cellulose) and compound bone cement of sodium alginate and Cyamopsis tetragonolobus gum (strengthen colloid and adopt melon glue).
Skeleton adhesive bonding method of the present invention is:
1) will be adherent skeleton earlier bubble in concentration is 0.01%～10% sodium alginate soln;
2) steeping after taking out in concentration again is 0.01% to saturated calcium chloride solution;
3) cover one deck calcium alginate film at broken bone surface;
4) the reuse skeletal agglutinant is smeared the embedding bonding;
5) agglutinating skeleton is soaked in 0～80 ℃ the calcium chloride solution solidification that soak time can realize bonding skeleton at least in 0.1 second.
Preferably sprinkle calsium supplement again on one deck calcium alginate film that broken bone surface covers, described calsium supplement is a kind of in calcium alginate, calcium phosphate, the calcium carbonate or their mixture.
Preferably repeating step 1 and 2 at least 1 times before step 3.
Compare with existing skeletal agglutinant, outstanding advantage of the present invention is: materials safety, kind are few, have better biocompatibility; The preparation technology of binding agent is simple, with low cost; The skeleton adhesive bonding method that adopts is convenient and swift, and adhesion strength is higher, solidifies rapidly, embodies higher efficient in the actual adhesion experiment, has added the calsium supplement that promotes bone healing simultaneously, helps the quickly-healing of skeleton.
The specific embodiment
Embodiment 1
Raw materials such as sodium alginate 1g, sodium carboxymethyl cellulose 3g and calsium supplement calcium alginate 1g are added in the 95g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
When adopting above-mentioned composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose to carry out skeleton when bonding, earlier will be adherent the skeleton bubble in concentration is 0.01% sodium alginate soln, steep again after the taking-up in concentration is 0.01% calcium chloride solution, repeat above-mentioned steps 2 times, cover one deck calcium alginate film at broken bone surface, on one deck calcium alginate film that broken bone surface covers, sprinkle calsium supplement calcium alginate or calcium phosphate again, the reuse skeletal agglutinant is smeared the embedding bonding, agglutinating skeleton is soaked in 80 ℃ the calcium chloride solution solidification that soak time can realize bonding skeleton in 1 second.
Embodiment 2
Raw materials such as sodium alginate 2g, sodium carboxymethyl cellulose 5g and calsium supplement calcium alginate 0.7g are added in the 92.3g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
When adopting above-mentioned composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose to carry out skeleton when bonding, earlier will be adherent the skeleton bubble in concentration is 5% sodium alginate soln, steep again after the taking-up in concentration is 1% calcium chloride solution, repeat above-mentioned steps 3 times, cover one deck calcium alginate film at broken bone surface, the reuse skeletal agglutinant is smeared embedding bonding, agglutinating skeleton is soaked in 0 ℃ the calcium chloride solution solidification that soak time can realize bonding skeleton in 0.1 second.
Embodiment 3
Raw materials such as sodium alginate 3g, sodium carboxymethyl cellulose 1g and calsium supplement calcium carbonate 2g are added in the 94g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
When adopting above-mentioned composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose to carry out skeleton when bonding, earlier will be adherent the skeleton bubble in concentration is 10% sodium alginate soln, steep again after the taking-up in saturated calcium chloride solution, repeat above-mentioned steps 4 times, cover one deck calcium alginate film at broken bone surface, on one deck calcium alginate film that broken bone surface covers, sprinkle calsium supplement calcium phosphate and calcium carbonate again, the reuse skeletal agglutinant is smeared the embedding bonding, agglutinating skeleton is soaked in 50 ℃ the calcium chloride solution solidification that soak time can realize bonding skeleton at least in 2 seconds.
Embodiment 4
Raw materials such as sodium alginate 4g, sodium carboxymethyl cellulose 10g and calsium supplement calcium phosphate 5g are added in the 81g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
When adopting above-mentioned composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose to carry out skeleton when bonding, earlier will be adherent the skeleton bubble in concentration is 0.03% sodium alginate soln, steep again after the taking-up in concentration is 0.1% calcium chloride solution, repeat above-mentioned steps 2 times, cover one deck calcium alginate film at broken bone surface, on one deck calcium alginate film that broken bone surface covers, sprinkle the calsium supplement calcium alginate again, calcium phosphate and calcium carbonate, the reuse skeletal agglutinant is smeared the embedding bonding, agglutinating skeleton is soaked in 60 ℃ the calcium chloride solution solidification that soak time can realize bonding skeleton in 1 minute.
Embodiment 5
Raw materials such as sodium alginate 5g, sodium carboxymethyl cellulose 8g and calsium supplement calcium alginate 1.5g and calcium phosphate 1g are added in the 84.5g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
When adopting above-mentioned composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose to carry out skeleton when bonding, earlier will be adherent the skeleton bubble in concentration is 8% sodium alginate soln, steep again after the taking-up in concentration is 10% calcium chloride solution, repeat above-mentioned steps 3 times, cover one deck calcium alginate film at broken bone surface, on one deck calcium alginate film that broken bone surface covers, sprinkle the calsium supplement calcium carbonate again or calcium carbonate adds calcium phosphate, the reuse skeletal agglutinant is smeared the embedding bonding, agglutinating skeleton is soaked in 40 ℃ the calcium chloride solution solidification that soak time can realize bonding skeleton in 2 minutes.
Embodiment 6
Raw materials such as sodium alginate 6g, sodium carboxymethyl cellulose 2g and calsium supplement calcium alginate 1.5g and calcium carbonate 1g are added in the 89.5g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Embodiment 7
Sodium alginate 7g and sodium carboxymethyl cellulose 4g raw material are added in the 89g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Embodiment 8
Raw materials such as sodium alginate 8g, sodium carboxymethyl cellulose 6g and calsium supplement calcium alginate 2g, calcium phosphate 1.5g and calcium carbonate 1.5g are added in the 81g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Embodiment 9
Raw materials such as sodium alginate 9g, sodium carboxymethyl cellulose 9g and calsium supplement calcium phosphate 1.5g and calcium carbonate 1.2g are added in the 79.3g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Embodiment 10
Raw materials such as sodium alginate 10g, sodium carboxymethyl cellulose 7g and calsium supplement calcium alginate 3g, calcium phosphate 2.5g and calcium carbonate 2g are added in the 75.5g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
Embodiment 11
Raw materials such as sodium alginate 2g, melon glue 6g and calsium supplement calcium alginate 1g are added in the 91g water, and mixing and stirring promptly obtains gelationus compound bone cement of sodium alginate and Cyamopsis tetragonolobus gum.
Embodiment 12
Raw materials such as sodium alginate 7g, melon glue 10g and calsium supplement calcium phosphate 5g and calcium carbonate 3.5g are added in the 74.5g water, and mixing and stirring promptly obtains gelationus compound bone cement of sodium alginate and Cyamopsis tetragonolobus gum.
Embodiment 13
Raw materials such as sodium alginate 5g, melon glue 1g and calsium supplement calcium phosphate 1.2g are added in the 92.8g water, and mixing and stirring promptly obtains gelationus compound bone cement of sodium alginate and Cyamopsis tetragonolobus gum.
Embodiment 14
Sodium alginate 7g and melon glue 4g raw material are added in the 89g water, and mixing and stirring promptly obtains gelationus compound bone cement of sodium alginate and Cyamopsis tetragonolobus gum.
Embodiment 15
Raw materials such as sodium alginate 9g, melon glue 9g and calsium supplement calcium carbonate 4.5g are added in the 77.5g water, and mixing and stirring promptly obtains gelationus compound bone cement of sodium alginate and Cyamopsis tetragonolobus gum.
Embodiment 16
Raw materials such as sodium alginate 4g, melon glue 5g and calsium supplement calcium alginate 1.5g, calcium carbonate 1g and calcium phosphate 1g are added in the 87.5g water, and mixing and stirring promptly obtains gelationus compound bone cement of sodium alginate and Cyamopsis tetragonolobus gum.
Embodiment 17
Raw materials such as sodium alginate 1g, melon glue 3g and calsium supplement calcium alginate 1g are added in the 95g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
When adopting above-mentioned compound bone cement of sodium alginate and Cyamopsis tetragonolobus gum to carry out skeleton when bonding, earlier will be adherent the skeleton bubble in concentration is 0.01% sodium alginate soln, steep again after the taking-up in concentration is 0.01% calcium chloride solution, repeat above-mentioned steps 2 times, cover one deck calcium alginate film at broken bone surface, on one deck calcium alginate film that broken bone surface covers, sprinkle calsium supplement calcium alginate or calcium phosphate again, the reuse skeletal agglutinant is smeared the embedding bonding, agglutinating skeleton is soaked in 80 ℃ the calcium chloride solution solidification that soak time can realize bonding skeleton in 1 second.
Embodiment 18
Raw materials such as sodium alginate 2g, melon glue 5g and calsium supplement calcium alginate 0.7g are added in the 92.3g water, and mixing and stirring promptly obtains gelationus compound bone cement of sodium alginate and Cyamopsis tetragonolobus gum.
When adopting above-mentioned compound bone cement of sodium alginate and Cyamopsis tetragonolobus gum to carry out skeleton when bonding, earlier will be adherent the skeleton bubble in concentration is 5% sodium alginate soln, steep again after the taking-up in concentration is 1% calcium chloride solution, repeat above-mentioned steps 3 times, cover one deck calcium alginate film at broken bone surface, the reuse skeletal agglutinant is smeared embedding bonding, agglutinating skeleton is soaked in 0 ℃ the calcium chloride solution solidification that soak time can realize bonding skeleton in 0.1 second.
Embodiment 19
Raw materials such as sodium alginate 3g, melon glue 1g and calsium supplement calcium carbonate 2g are added in the 94g water, and mixing and stirring promptly obtains gelationus compound bone cement of sodium alginate and Cyamopsis tetragonolobus gum.
When adopting above-mentioned compound bone cement of sodium alginate and Cyamopsis tetragonolobus gum to carry out skeleton when bonding, earlier will be adherent the skeleton bubble in concentration is 10% sodium alginate soln, steep again after the taking-up in saturated calcium chloride solution, repeat above-mentioned steps 4 times, cover one deck calcium alginate film at broken bone surface, on one deck calcium alginate film that broken bone surface covers, sprinkle calsium supplement calcium phosphate and calcium carbonate again, the reuse skeletal agglutinant is smeared the embedding bonding, agglutinating skeleton is soaked in 50 ℃ the calcium chloride solution solidification that soak time can realize bonding skeleton at least in 2 seconds.
Embodiment 20
Raw materials such as sodium alginate 4g, melon glue 10g and calsium supplement calcium phosphate 5g are added in the 81g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
When adopting above-mentioned compound bone cement of sodium alginate and Cyamopsis tetragonolobus gum to carry out skeleton when bonding, earlier will be adherent the skeleton bubble in concentration is 0.03% sodium alginate soln, steep again after the taking-up in concentration is 0.1% calcium chloride solution, repeat above-mentioned steps 2 times, cover one deck calcium alginate film at broken bone surface, on one deck calcium alginate film that broken bone surface covers, sprinkle the calsium supplement calcium alginate again, calcium phosphate and calcium carbonate, the reuse skeletal agglutinant is smeared the embedding bonding, agglutinating skeleton is soaked in 60 ℃ the calcium chloride solution solidification that soak time can realize bonding skeleton in 1 minute.
Embodiment 21
Raw materials such as sodium alginate 5g, melon glue 8g and calsium supplement calcium alginate 1.5g and calcium phosphate 1g are added in the 84.5g water, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose.
When adopting above-mentioned compound bone cement of sodium alginate and Cyamopsis tetragonolobus gum to carry out skeleton when bonding, earlier will be adherent the skeleton bubble in concentration is 8% sodium alginate soln, steep again after the taking-up in concentration is 10% calcium chloride solution, repeat above-mentioned steps 3 times, cover one deck calcium alginate film at broken bone surface, on one deck calcium alginate film that broken bone surface covers, sprinkle the calsium supplement calcium carbonate again or calcium carbonate adds calcium phosphate, the reuse skeletal agglutinant is smeared the embedding bonding, agglutinating skeleton is soaked in 40 ℃ the calcium chloride solution solidification that soak time can realize bonding skeleton in 2 minutes.
Claims (7)
1. skeletal agglutinant is characterized in that it is formed and content by mass percentage is:
Sodium alginate: 1%～10%;
Strengthen colloid: 1%～10%;
Calsium supplement: 0%～50% of sodium alginate and reinforcement colloid gross mass;
All the other compositions are water.
2. skeletal agglutinant as claimed in claim 1 is characterized in that described reinforcement colloid is sodium carboxymethyl cellulose or melon glue.
3. skeletal agglutinant as claimed in claim 1 is characterized in that described calsium supplement is a kind of in calcium alginate, calcium phosphate, the calcium carbonate or their mixture.
4. the preparation method of skeletal agglutinant as claimed in claim 1 is characterized in that its step for each components in certain proportion is added in the entry, and mixing and stirring promptly obtains gelationus composite skeletal agglutinant made.
5. the adhesive bonding method of skeletal agglutinant as claimed in claim 1 is characterized in that the steps include:
1) will be adherent skeleton earlier bubble in concentration is 0.01%～10% sodium alginate soln;
2) steeping after taking out in concentration again is 0.01% to saturated calcium chloride solution;
3) repeating step 1 and 2 at least 2 times cover one deck calcium alginate film at broken bone surface;
4) the reuse skeletal agglutinant is smeared the embedding bonding;
5) agglutinating skeleton is soaked in 0～80 ℃ the calcium chloride solution solidification that soak time can realize bonding skeleton at least in 0.1 second.
6. the adhesive bonding method of skeletal agglutinant as claimed in claim 5 is characterized in that sprinkling calsium supplement again on one deck calcium alginate film that broken bone surface covers.
7. the adhesive bonding method of skeletal agglutinant as claimed in claim 6 is characterized in that described calsium supplement is a kind of in calcium alginate, calcium phosphate, the calcium carbonate or their mixture.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006101228735A CN100500227C (en) | 2006-10-23 | 2006-10-23 | Skeletal agglutinant conglutinating method |
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| CNB2006101228735A CN100500227C (en) | 2006-10-23 | 2006-10-23 | Skeletal agglutinant conglutinating method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100435858C (en) * | 2006-10-23 | 2008-11-26 | 厦门大学 | The composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose and its preparation method |
| CN110947368A (en) * | 2019-11-27 | 2020-04-03 | 齐鲁工业大学 | Preparation and curing method of sodium alginate-lignin composite gel beads |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2322864A (en) * | 1997-03-07 | 1998-09-09 | Polybiomed Ltd | Gel for application to the human or animal body |
| JP2002523525A (en) * | 1998-08-18 | 2002-07-30 | バイオマット サイエンス，インク． | Adhesive composition for human hard tissue |
| JP4675456B2 (en) * | 1999-05-31 | 2011-04-20 | 株式会社クラレ | Adhesive composition |
| CN1162187C (en) * | 2001-02-22 | 2004-08-18 | 华东理工大学 | Inorganic bane adhesive and its application in body's hard tissue repair |
| EP1364663A1 (en) * | 2002-05-21 | 2003-11-26 | Commonwealth Scientific And Industrial Research Organisation | Ocular devices with functionalized surface with adhesive properties |
| CN100435858C (en) * | 2006-10-23 | 2008-11-26 | 厦门大学 | The composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose and its preparation method |
| CN100525843C (en) * | 2006-10-25 | 2009-08-12 | 集美大学 | Compound bone cement of sodium alginate and Cyamopsis tetragonolobus gum and preparation method thereof |
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2006
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100435858C (en) * | 2006-10-23 | 2008-11-26 | 厦门大学 | The composite skeletal agglutinant made by sodium alginate-carboxyl methyl cellulose and its preparation method |
| CN110947368A (en) * | 2019-11-27 | 2020-04-03 | 齐鲁工业大学 | Preparation and curing method of sodium alginate-lignin composite gel beads |
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