CN105999241A - 一种防治牙周病的复方含漱液及其制备方法 - Google Patents

一种防治牙周病的复方含漱液及其制备方法 Download PDF

Info

Publication number
CN105999241A
CN105999241A CN201610454035.1A CN201610454035A CN105999241A CN 105999241 A CN105999241 A CN 105999241A CN 201610454035 A CN201610454035 A CN 201610454035A CN 105999241 A CN105999241 A CN 105999241A
Authority
CN
China
Prior art keywords
extract
parts
vitamin
periodontal disease
baicalin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610454035.1A
Other languages
English (en)
Inventor
吴克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Qilikang Skin Pharmaceutical Co Ltd
Original Assignee
Jiangsu Qilikang Skin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Qilikang Skin Pharmaceutical Co Ltd filed Critical Jiangsu Qilikang Skin Pharmaceutical Co Ltd
Priority to CN201610454035.1A priority Critical patent/CN105999241A/zh
Publication of CN105999241A publication Critical patent/CN105999241A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355Tocopherols, e.g. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/58Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/77Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/82Theaceae (Tea family), e.g. camellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本案公开了一种防止牙周病的复方含漱液,包括以下成分:荔枝核提取物;苦楝皮提取物;绿茶提取物;野菊花水提取物;黄芩苷提取物;芒箕提取物;马齿苋提取物;维生素E;维生素C;葡萄糖酸钠;醋酸氯己啶;β‑葡聚糖酶;去离子水。本发明提供一种防治牙周病复方含漱液,清凉爽口,并能防治牙周病,同时其中含有的中药成分,还能降火消毒,预防感冒。

Description

一种防治牙周病的复方含漱液及其制备方法
技术领域
本发明属于中药领域,涉及一种含漱液及其制备方法,特别是涉及一种防治牙周病的复方含漱液及其制备方法。
背景技术
牙周疾病是常见的口腔疾病,是引起成年人牙齿丧失的主要原因之一,也是危害人类牙齿和全身健康的主要口腔疾病。但以往人们错误的认为只有到老年才会受到牙周病的困扰,其实从5岁开始,牙周病就开始“腐蚀”我们的健康了。牙周病的早期症状不易引起重视,造成牙周组织长期慢性感染,炎症反复发作,到患者就诊时病情已相当严重,不仅损害口腔咀嚼系统的功能,还会严重影响全身健康。
牙周病的预防,刻不容缓。
防治牙周病,要从口腔做起,但是目前市面上,还没有一种漱口液,可以在清洁口腔的基础上,还能预防牙周病。
发明内容
针对上述不足之处,本发明的目的在于提供一种防治牙周病复方含漱液,清凉爽口,并能防治牙周病,同时其中含有的中药成分,还能降火消毒,预防感冒。
本发明的技术方案概述如下:一种防止牙周病的复方含漱液,包括以下重量份的成分:荔枝核提取物4~10份;苦楝皮提取物1~3份;绿茶提取物1~10份;野菊花水提取物2~8份;黄芩苷提取物2~5份;芒箕提取物3~8份;马齿苋提取物3~8份;维生素E0.1~3份;维生素C1~7份;苦味抑制剂0.3~3份;氯己啶1~6份;β-葡聚糖酶0.5~3份;去离子水80~180份。
优选的是,包括以下重量份的成分:荔枝核提取物5~8份;苦楝皮提取物1~2份;绿茶提取物2~7份;野菊花水提取物4~7份;黄芩苷提取物3~4.5份;芒箕提取物4~6份;马齿苋提取物4~6份;维生素E0.5~2份;维生素C3~6份;苦味抑制剂0.5~2份;氯己啶1~3份;β-葡聚糖酶1~3份;去离子水100~160份。
优选的是,包括以下重量份的成分:荔枝核提取物6份;苦楝皮提取物1.5份;绿茶提取物4份;野菊花水提取物6份;黄芩苷提取物4份;芒箕提取物5份;马齿苋提取物5份;维生素E1份;维生素C4份;苦味抑制剂1份;氯己啶2份;β-葡聚糖酶2份;去离子水140份。
优选的是,所述苦味抑制剂选自甘氨酸钠、葡萄糖酸钠中的一种。
优选的是,所述氯己啶选自醋酸氯己啶、葡萄糖酸氯己啶的一种。
本案的另一个目的是提供一种防止牙周病的复方含漱液的制备方法,包括如下步骤:
步骤1):取荔枝核、苦楝皮、绿茶、野菊花、黄芩苷、芒箕、马齿苋捣碎,捣碎后分别加入热水浸泡1~4小时,再进行搅拌热浸提,热浸提后离心,收集上清液,分别将上清液浓缩,分别得到荔枝核提取物、苦楝皮提取物、绿茶提取物、野菊花提取物、黄芩苷提取物、芒箕提取物、马齿苋提取物;
步骤2):按重量份称取荔枝核提取物、苦楝皮提取物、绿茶提取物、野菊花提取物、黄芩苷提取物、芒箕提取物、马齿苋提取物、维生素E1份、维生素C、;苦味抑制剂、氯己啶、β-葡聚糖酶以及去离子水,将上述的各种提取物及其他辅料混合均匀,得到防治牙周病的复方含漱液。
优选的是,步骤(1)中热水浸泡2h,浸提温度为50~60℃,浸提时间为3~5h,料液重量比为1:5~1:10。
本发明的有益效果是:本案提供一种防治牙周病的复方含漱液,可以清洁口腔细菌,预防牙周炎,同时还能预防感冒,且口感清爽,味道清香。
具体实施方式
下面结合实施例对本发明做进一步的详细说明,以令本领域技术人员参照说明书文字能够据以实施。
实施例1
一种防止牙周病的复方含漱液,包括以下重量份的成分:荔枝核提取物4份;苦楝皮提取物1份;绿茶提取物1份;野菊花水提取物2份;黄芩苷提取物2份;芒箕提取物3份;马齿苋提取物3份;维生素E0.1份;维生素C1份;葡萄糖酸钠0.3份;醋酸氯己啶1份;β-葡聚糖酶0.5份;去离子水80份。
其制备方法包容如下步骤:
步骤1):取荔枝核、苦楝皮、绿茶、野菊花、黄芩苷、芒箕、马齿苋捣碎,捣碎后分别加入热水浸泡1小时,再进行搅拌热浸提,浸提温度为50℃,浸提时间为3h,料液重量比为1:5,热浸提后离心,收集上清液,分别将上清液浓缩,分别得到荔枝核提取物、苦楝皮提取物、绿茶提取物、野菊花提取物、黄芩苷提取物、芒箕提取物、马齿苋提取物;
步骤2):按重量份称取荔枝核提取物、苦楝皮提取物、绿茶提取物、野菊花提取物、黄芩苷提取物、芒箕提取物、马齿苋提取物、维生素E1份、维生素C、;苦味抑制剂、氯己啶、β-葡聚糖酶以及去离子水,将上述的各种提取物及其他辅料混合均匀,得到防治牙周病的复方含漱液。
实施例2
一种防止牙周病的复方含漱液,包括以下重量份的成分:荔枝核提取物10份;苦楝皮提取物3份;绿茶提取物10份;野菊花水提取物8份;黄芩苷提取物5份;芒箕提取物8份;马齿苋提取物8份;维生素E3份;维生素C7份;葡萄糖酸钠3份;醋酸氯己啶6份;β-葡聚糖酶3份;去离子水180份。
其制备方法包容如下步骤:
步骤1):取荔枝核、苦楝皮、绿茶、野菊花、黄芩苷、芒箕、马齿苋捣碎,捣碎后分别加入热水浸泡4小时,再进行搅拌热浸提,浸提温度为60℃,浸提时间为5h,料液重量比为1:10,热浸提后离心,收集上清液,分别将上清液浓缩,分别得到荔枝核提取物、苦楝皮提取物、绿茶提取物、野菊花提取物、黄芩苷提取物、芒箕提取物、马齿苋提取物;
步骤2):按重量份称取荔枝核提取物、苦楝皮提取物、绿茶提取物、野菊花提取物、黄芩苷提取物、芒箕提取物、马齿苋提取物、维生素E1份、维生素C、;苦味抑制剂、氯己啶、β-葡聚糖酶以及去离子水,将上述的各种提取物及其他辅料混合均匀,得到防治牙周病的复方含漱液。
实施例3
一种防止牙周病的复方含漱液,包括以下重量份的成分:荔枝核提取物8份;苦楝皮提取物2份;绿茶提取物7份;野菊花水提取物7份;黄芩苷提取物4.5份;芒箕提取物6份;马齿苋提取物6份;维生素E2份;维生素C6份;葡萄糖酸钠2份;葡萄糖酸氯己啶3份;β-葡聚糖酶3份;去离子水160份。
其制备方法包容如下步骤:
步骤1):取荔枝核、苦楝皮、绿茶、野菊花、黄芩苷、芒箕、马齿苋捣碎,捣碎后分别加入热水浸泡2小时,再进行搅拌热浸提,浸提温度为55℃,浸提时间为4h,料液重量比为1:8,热浸提后离心,收集上清液,分别将上清液浓缩,分别得到荔枝核提取物、苦楝皮提取物、绿茶提取物、野菊花提取物、黄芩苷提取物、芒箕提取物、马齿苋提取物;
步骤2):按重量份称取荔枝核提取物、苦楝皮提取物、绿茶提取物、野菊花提取物、黄芩苷提取物、芒箕提取物、马齿苋提取物、维生素E1份、维生素C、苦味抑制剂、氯己啶、β-葡聚糖酶以及去离子水,将上述的各种提取物及其他辅料混合均匀,得到防治牙周病的复方含漱液。
实施例4
一种防止牙周病的复方含漱液,包括以下重量份的成分:荔枝核提取物5份;苦楝皮提取物1份;绿茶提取物2份;野菊花水提取物4份;黄芩苷提取物3份;芒箕提取物4份;马齿苋提取物4份;维生素E0.5份;维生素C3份;葡萄糖酸钠0.5份;葡萄糖酸氯己啶1份;β-葡聚糖酶1份;去离子水100份。
其制备方法包容如下步骤:
步骤1):取荔枝核、苦楝皮、绿茶、野菊花、黄芩苷、芒箕、马齿苋捣碎,捣碎后分别加入热水浸泡3小时,再进行搅拌热浸提,浸提温度为56℃,浸提时间为4.5h,料液重量比为1:6,热浸提后离心,收集上清液,分别将上清液浓缩,分别得到荔枝核提取物、苦楝皮提取物、绿茶提取物、野菊花提取物、黄芩苷提取物、芒箕提取物、马齿苋提取物;
步骤2):按重量份称取荔枝核提取物、苦楝皮提取物、绿茶提取物、野菊花提取物、黄芩苷提取物、芒箕提取物、马齿苋提取物、维生素E1份、维生素C、苦味抑制剂、氯己啶、β-葡聚糖酶以及去离子水,将上述的各种提取物及其他辅料混合均匀,得到防治牙周病的复方含漱液。
实施例5
一种防止牙周病的复方含漱液,包括以下重量份的成分:荔枝核提取物6份;苦楝皮提取物1.5份;绿茶提取物4份;野菊花水提取物6份;黄芩苷提取物4份;芒箕提取物5份;马齿苋提取物5份;维生素E1份;维生素C4份;甘氨酸钠1份;醋酸氯己啶2份;β-葡聚糖酶2份;去离子水140份。
其制备方法包容如下步骤:
步骤1):取荔枝核、苦楝皮、绿茶、野菊花、黄芩苷、芒箕、马齿苋捣碎,捣碎后分别加入热水浸泡2小时,再进行搅拌热浸提,浸提温度为50℃,浸提时间为4h,料液重量比为1:8,热浸提后离心,收集上清液,分别将上清液浓缩,分别得到荔枝核提取物、苦楝皮提取物、绿茶提取物、野菊花提取物、黄芩苷提取物、芒箕提取物、马齿苋提取物;
步骤2):按重量份称取荔枝核提取物、苦楝皮提取物、绿茶提取物、野菊花提取物、黄芩苷提取物、芒箕提取物、马齿苋提取物、维生素E1份、维生素C、;苦味抑制剂、氯己啶、β-葡聚糖酶以及去离子水,将上述的各种提取物及其他辅料混合均匀,得到防治牙周病的复方含漱液。
尽管本发明的实施方案已公开如上,但其并不仅仅限于说明书和实施方式中所列运用,它完全可以被适用于各种适合本发明的领域,对于熟悉本领域的人员而言,可容易地实现另外的修改,因此在不背离权利要求及等同范围所限定的一般概念下,本发明并不限于特定的细节。

Claims (7)

1.一种防止牙周病的复方含漱液,其特征在于,包括以下重量份的成分:荔枝核提取物4~10份;苦楝皮提取物1~3份;绿茶提取物1~10份;野菊花水提取物2~8份;黄芩苷提取物2~5份;芒箕提取物3~8份;马齿苋提取物3~8份;维生素E0.1~3份;维生素C1~7份;苦味抑制剂0.3~3份;氯己啶1~6份;β-葡聚糖酶0.5~3份;去离子水80~180份。
2.如权利要求1所述的防止牙周病的复方含漱液,其特征在于,包括以下重量份的成分:荔枝核提取物5~8份;苦楝皮提取物1~2份;绿茶提取物2~7份;野菊花水提取物4~7份;黄芩苷提取物3~4.5份;芒箕提取物4~6份;马齿苋提取物4~6份;维生素E0.5~2份;维生素C3~6份;苦味抑制剂0.5~2份;氯己啶1~3份;β-葡聚糖酶1~3份;去离子水100~160份。
3.如权利要求1所述的防止牙周病的复方含漱液,其特征在于,包括以下重量份的成分:荔枝核提取物6份;苦楝皮提取物1.5份;绿茶提取物4份;野菊花水提取物6份;黄芩苷提取物4份;芒箕提取物5份;马齿苋提取物5份;维生素E1份;维生素C4份;苦味抑制剂1份;氯己啶2份;β-葡聚糖酶2份;去离子水140份。
4.如权利要求1所述的防止牙周病的复方含漱液,其特征在于,所述苦味抑制剂选自甘氨酸钠、葡萄糖酸钠中的一种。
5.如权利要求1所述的防止牙周病的复方含漱液,其特征在于,所述氯己啶选自醋酸氯己啶、葡萄糖酸氯己啶的一种。
6.如权利要求1所述的防止牙周病的复方含漱液的制备方法,其特征在于,包括如下步骤:
步骤1):取荔枝核、苦楝皮、绿茶、野菊花、黄芩苷、芒箕、马齿苋捣碎,捣碎后分别加入热水浸泡1~4小时,再进行搅拌热浸提,热浸提后离心,收集上清液,分别将上清液浓缩,分别得到荔枝核提取物、苦楝皮提取物、绿茶提取物、野菊花提取物、黄芩苷提取物、芒箕提取物、马齿苋提取物;
步骤2):按重量份称取荔枝核提取物、苦楝皮提取物、绿茶提取物、野菊花提取物、黄芩苷提取物、芒箕提取物、马齿苋提取物、维生素E1份、维生素C、;苦味抑制剂、氯己啶、β-葡聚糖酶以及去离子水,将上述的各种提取物及其他辅料混合均匀,得到防治牙周病的复方含漱液。
7.如权利要求5所述的防止牙周病的复方含漱液制备方法,其特征在于,步骤(1)中热水浸泡2h,浸提温度为50~60℃,浸提时间为3~5h,料液重量比为1:5~1:10。
CN201610454035.1A 2016-06-21 2016-06-21 一种防治牙周病的复方含漱液及其制备方法 Pending CN105999241A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610454035.1A CN105999241A (zh) 2016-06-21 2016-06-21 一种防治牙周病的复方含漱液及其制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610454035.1A CN105999241A (zh) 2016-06-21 2016-06-21 一种防治牙周病的复方含漱液及其制备方法

Publications (1)

Publication Number Publication Date
CN105999241A true CN105999241A (zh) 2016-10-12

Family

ID=57087048

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610454035.1A Pending CN105999241A (zh) 2016-06-21 2016-06-21 一种防治牙周病的复方含漱液及其制备方法

Country Status (1)

Country Link
CN (1) CN105999241A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111743844A (zh) * 2020-07-10 2020-10-09 皖南医学院第一附属医院(皖南医学院弋矶山医院) 一种中药复方漱口液及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102366364A (zh) * 2011-10-24 2012-03-07 汕头市江源化工有限公司 一种牙周病含漱液
CN103536497A (zh) * 2013-10-30 2014-01-29 昆明理工大学 一种中药复方漱口液及其制备方法
CN103735437A (zh) * 2013-12-04 2014-04-23 何小刚 草本漱口液
CN104383335A (zh) * 2014-11-28 2015-03-04 刘小芳 一种治疗牙周炎的中药组合物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102366364A (zh) * 2011-10-24 2012-03-07 汕头市江源化工有限公司 一种牙周病含漱液
CN103536497A (zh) * 2013-10-30 2014-01-29 昆明理工大学 一种中药复方漱口液及其制备方法
CN103735437A (zh) * 2013-12-04 2014-04-23 何小刚 草本漱口液
CN104383335A (zh) * 2014-11-28 2015-03-04 刘小芳 一种治疗牙周炎的中药组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
窦永青 等: "黄芩苷局部应用治疗慢性牙周炎的疗效观察", 《实用口腔医学杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111743844A (zh) * 2020-07-10 2020-10-09 皖南医学院第一附属医院(皖南医学院弋矶山医院) 一种中药复方漱口液及其制备方法

Similar Documents

Publication Publication Date Title
CN103705883B (zh) 一种治疗皮肤病的药物与制备
CN1947697B (zh) 一种草本真水溶液型口腔清洁剂及其制备方法
CN104382786A (zh) 一种防脱乌发剂及其制备方法
CN105030621A (zh) 一种保湿祛痘爽肤水及其制备方法
CN103520502A (zh) 一种治疗牙龈炎的中药制剂及其制备方法
CN104397817A (zh) 一种清热解毒保健饮料及其制备方法
CN104688629A (zh) 一种防口腔溃炎的漱口水
CN103735437A (zh) 草本漱口液
CN106309325A (zh) 一种抗菌消炎漱口水及其制备方法
CN109549887A (zh) 一种消炎漱口水
CN105999241A (zh) 一种防治牙周病的复方含漱液及其制备方法
CN105997792A (zh) 一种中药防蛀护齿含漱液及其制备方法
CN105381096A (zh) 用于治疗由热毒引起的青春痘的药物
CN103735481A (zh) 一种抗菌消炎漱口水及其制备方法
CN104013063B (zh) 一种除口臭饮品及漱口水
CN103828974A (zh) 一种健康减肥茶
CN104721348A (zh) 一种治疗急性泪囊炎的中药汤剂及其制备方法
CN105477435A (zh) 一种用于治疗牙龈出血的中药
CN104069399A (zh) 消除消化不良型口臭的中药汤剂及制备方法
CN104490675A (zh) 一种防治牙龈出血的牙膏
CN103565707A (zh) 一种抗病毒中药沐浴露
CN109549886A (zh) 一种消炎漱口水的制备方法
KR100842037B1 (ko) 훈증,좌욕용 목욕액의 제조방법
CN103751054B (zh) 一种连翘叶含漱液及其制备方法
CN108094782A (zh) 一种防病保健饮料及其制法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20161012