CN105999146A - 防晕车的润喉含片及制备方法 - Google Patents
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Abstract
本发明公开了一种防晕车的润喉含片及制备方法，属于中药技术领域，其有效成分包括以下原料：白萝卜提取物、白花蛇舌草、蜂蜜、决明子、薄荷、金银花、郁李仁、苦杏仁、藿香和佛手，本发明以草本植物为配方，药食同源，无任何毒副作用，气味芳香，入口清新，老少皆宜；防止晕车、晕船效果显著，药效时间优于现有同类产品。
Description
技术领域
本发明涉及中药技术领域，具体是一种防晕车的润喉含片及制备方法。
背景技术
晕车，英文名称 motion sickness，也叫晕动病，晕车病，晕船病，晕机病，宇宙晕动病，是汽车、轮船或飞机运动时所产生的颠簸、摇摆或旋转等任何形式的加速运动，刺激人体的前庭神经而发生的疾病；患者初时感觉上腹不适，继有恶心、面色苍白、出冷汗，旋即有眩晕、精神抑郁、唾液分泌增多和呕吐；本病常在乘车、航海、飞行和其他运行数分钟至数小时后发生；初时感觉上腹不适，继有恶心、面色苍白、出冷汗，旋即有眩晕、精神抑郁、唾液分泌增多和呕吐；严重者可有血压下降、呼吸深而慢、眼球震颤；严重呕吐引起失水和电解质紊乱；症状一般在停止运行或减速后数十分钟和几小时内消失或减轻；经多次发病后，症状反可减轻，甚至不发生。目前的治疗手段主要有药物治疗和手术治疗，西医进行药物治疗时常选用抗组胺和抗胆硷类药物，如氢溴酸东莨菪碱、苯海拉明、盐酸倍他司汀、盐酸美克洛嗪等，这些药物主要是抑制神经中枢兴奋，缓解消化道痉挛，常伴有嗜睡、口干、疲劳等副作用，使用禁忌症较多，且不适宜长期服用；中医进行药物治疗的中药较多，但很多组方中添加了有一定毒性的药物，也存在嗜睡易疲劳等副作用；手术治疗较少进行，行前庭神经切断术后有产生严重后遗症的风险，患者依从性不好；现有的中药晕车药效果因人而异，市场上现有的防治晕车的糖果一粒糖果的药效时间仅为1-2小时，若为长途坐车，过了药效时间则依然会出现晕车症状。
发明内容
为解决现有技术存在的缺陷，本发明旨在提供一种药食同源，无毒副作用，药效时间长的防晕车的润喉含片及制备方法。
为了实现上述目的，本发明的技术方案为：
一种防晕车的润喉含片，其有效成分包括以下原料：胖大海、佛手、生姜、蜂蜜、决明子、麦冬、甘草、陈皮、郁李仁、茯苓、枸杞和薄荷。
本发明还可以具有以下附加技术特征：
优选的，其各原料按重量份计为：胖大海8-12份、佛手5-8份、生姜3-5份、蜂蜜3-6份、决明子7-12份、麦冬5-8份、甘草8-13份、陈皮3-6份、郁李仁8-12份、茯苓7-12份、枸杞3-6份和薄荷3-8份。
优选的，其各原料按重量份计为：胖大海10份、佛手7份、生姜4份、蜂蜜5份、决明子10份、麦冬6份、甘草10份、陈皮5份、郁李仁10份、茯苓10份、枸杞4份和薄荷5份。
优选的，其各原料按重量份计为：胖大海12份、佛手5份、生姜5份、蜂蜜3份、决明子7份、麦冬8份、甘草8份、陈皮6份、郁李仁8份、茯苓7份、枸杞6份和薄荷8份。
优选的，其各原料按重量份计为：胖大海8份、佛手8份、生姜3份、蜂蜜6份、决明子12份、麦冬5份、甘草13份、陈皮3份、郁李仁8份、茯苓12份、枸杞3份和薄荷3份。
本发明还提供上述的防晕车的润喉含片的制备方法，包括以下步骤：
步骤1：按处方量称取胖大海、佛手、生姜、决明子、麦冬、甘草、陈皮、郁李仁、茯苓、枸杞和薄荷加水浸泡1-2小时后，加入其质量5-8倍的水在80-100℃超声提取2-4小时，过滤得到一次滤液，滤渣加水超声提取0.5-1小时，过滤得到二次滤液，合并两次滤液，备用；
步骤2：将步骤1所得合并滤液浓缩为50℃时相对密度为1.2-1.3的膏状物，加入蜂蜜混合均匀后，加入制备含片常规辅料，按照常规工艺制成含片。
本发明的方法还可以具有以下附加技术特征：
优选的，所述制备含片常规辅料包括焦糖色、白砂糖和液体葡萄糖。
优选的，所述蜂蜜为椴树蜜。
本发明的有益效果为：本发明以草本植物为配方，药食同源，无任何毒副作用，气味芳香，入口清新，老少皆宜；防止晕车、晕船效果显著，药效时间优于现有同类产品，且兼具润喉作用。
本发明的附加方面和优点将在下面的描述中部分给出，部分将从下面的描述中变得明显，或通过本发明的实践了解到。
具体实施方式
以下结合具体实例，对本发明进行详细说明。
实施例1
a.准备以下原料：
胖大海100g、佛手70g、生姜40g、蜂蜜50g、决明子100g、麦冬60g、甘草100g、陈皮50g、郁李仁100g、茯苓100g、枸杞40g和薄荷50g；
b.采用以下步骤制备含片：
按处方量称取胖大海、佛手、生姜、决明子、麦冬、甘草、陈皮、郁李仁、茯苓、枸杞和薄荷加水浸泡1.5小时后，加入其质量6倍的水在90℃超声提3小时，过滤得到一次滤液，滤渣加水超声提取40min，过滤得到二次滤液，合并两次滤液，将合并滤液浓缩为50℃时相对密度为1.24的膏状物，加入蜂蜜混合均匀后，加入焦糖色、白砂糖、液体葡萄糖和食用香料在100℃以内熬煮使干物质含量达到96%倒模成型制成含片，每粒糖重量为1.8g，药物成分含量为20%。
对于蜂蜜，不同的蜂蜜成分不同，药效不同，对于本发明的糖果，最好的蜂蜜为椴树蜜，主要作用的调节口感，气味，及润肺。
实施例2
a.准备以下原料：
胖大海120g、佛手50g、生姜50g、蜂蜜30g、决明子70g、麦冬80g、甘草80g、陈皮60g、郁李仁80g、茯苓70g、枸杞60g和薄荷80g；
b.采用以下步骤制备含片：
按处方量称取胖大海、佛手、生姜、决明子、麦冬、甘草、陈皮、郁李仁、茯苓、枸杞和薄荷加水浸泡1小时后，加入其质量8倍的水在100℃超声提取2小时，过滤得到一次滤液，滤渣加水超声提取1小时，过滤得到二次滤液，合并两次滤液，将合并滤液浓缩为50℃时相对密度为1.23的膏状物，加入蜂蜜混合均匀后，加入焦糖色、白砂糖、液体葡萄糖和食用香料在100℃以内熬煮使干物质含量达到97%倒模成型制成含片，每粒糖重量为1.8g，药物成分含量为20%。
实施例3
a.准备以下原料：
胖大海80g、佛手80g、生姜30g、蜂蜜60g、决明子120g、麦冬50g、甘草130g、陈皮30g、郁李仁80g、茯苓120g、枸杞30g和薄荷30g；
b.采用以下步骤制备含片：
按处方量称取胖大海、佛手、生姜、决明子、麦冬、甘草、陈皮、郁李仁、茯苓、枸杞和薄荷加水浸泡2小时后，加入其质量5倍的水在100℃超声提取4小时，过滤得到一次滤液，滤渣加水超声提取1小时，过滤得到二次滤液，合并两次滤液，将合并滤液浓缩为50℃时相对密度为1.27的膏状物，加入蜂蜜混合均匀后，加入焦糖色、白砂糖、液体葡萄糖和食用香料在100℃以内熬煮使干物质含量达到96%倒模成型制成含片，每粒糖重量为1.8g，药物成分含量为20%。
实施例4 药效检测
实验方法：选择200位晕动症患者作为受试者，年龄分布为9-76岁，其中100位在乘车或者坐船前半小时服用本发明的含片一粒，另100位受试者服用现有的某公司生产的中药晕车含片作为对比，受试者的乘车或坐船时间为1-10小时不等，记录受试者乘车或坐船过程中的身体感觉，如表1；
评定标准：
显效：乘坐汽车、飞机、船舶无任何不适之感觉，一切正常；
有效：晕车现象减轻或明显减轻； 无效：受试者感到胃部不适、恶心、呕吐、出冷汗、窒息、身体难受，晕车现象无任何改善，使用前与使用后无差别；
效果评定按照车程的全程反应评定，若在车程前期有效后期无效则依然评价为无效；
表1 服用效果表
由表1可见，本发明的防晕车含片显效效果可维持6小时，明显优于对比例的糖果，随着车程时间延长，效果降低，乘车6小时后会出现轻微的不适感，对比例药物在3小时后效果明显降低，并且在三小时内的显效率低于本发明的含片，表1表明，本发明的药物药效明显优于对比例，并且本发明的药物气味芳香，口感好，入口清新，老少皆宜，无疲劳/嗜睡等不良反应深受群众喜爱。
尽管已经示出和描述了本发明的实施例，本领域的普通技术人员可以理解：在不脱离本发明的原理和宗旨的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由权利要求及其等同物限定。
Claims (8)
1.一种防晕车的润喉含片，其特征在于，其有效成分包括以下原料：胖大海、佛手、生姜、蜂蜜、决明子、麦冬、甘草、陈皮、郁李仁、茯苓、枸杞和薄荷。
2.根据权利要求1所述的防晕车的润喉含片，其特征在于，其各原料按重量份计为：胖大海8-12份、佛手5-8份、生姜3-5份、蜂蜜3-6份、决明子7-12份、麦冬5-8份、甘草8-13份、陈皮3-6份、郁李仁8-12份、茯苓7-12份、枸杞3-6份和薄荷3-8份。
3.根据权利要求1所述的防晕车的润喉含片，其特征在于，其各原料按重量份计为：胖大海10份、佛手7份、生姜4份、蜂蜜5份、决明子10份、麦冬6份、甘草10份、陈皮5份、郁李仁10份、茯苓10份、枸杞4份和薄荷5份。
4.根据权利要求1所述的防晕车的润喉含片，其特征在于，其各原料按重量份计为：胖大海12份、佛手5份、生姜5份、蜂蜜3份、决明子7份、麦冬8份、甘草8份、陈皮6份、郁李仁8份、茯苓7份、枸杞6份和薄荷8份。
5.根据权利要求1所述的防晕车的润喉含片，其特征在于，其各原料按重量份计为：胖大海8份、佛手8份、生姜3份、蜂蜜6份、决明子12份、麦冬5份、甘草13份、陈皮3份、郁李仁8份、茯苓12份、枸杞3份和薄荷3份。
6.权利要求1-5任一项所述的所述的防晕车的润喉含片的制备方法，其特征在于，包括以下步骤：
步骤1：按处方量称取胖大海、佛手、生姜、决明子、麦冬、甘草、陈皮、郁李仁、茯苓、枸杞和薄荷加水浸泡1-2小时后，加入其质量5-8倍的水在80-100℃超声提取2-4小时，过滤得到一次滤液，滤渣加水超声提取0.5-1小时，过滤得到二次滤液，合并两次滤液，备用；
步骤2：将步骤1所得合并滤液浓缩为50℃时相对密度为1.2-1.3的膏状物，加入蜂蜜混合均匀后，加入制备含片常规辅料，按照常规工艺制成含片。
7.根据权利要求6所述的防晕车的润喉含片的制备方法，其特征在于，所述制备含片常规辅料包括焦糖色、白砂糖和液体葡萄糖。
8.根据权利要求6所述的防晕车的润喉含片的制备方法，其特征在于，所述蜂蜜为椴树蜜。
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