CN105998758A - Preparation methods of traditional Chinese medicinal composition for treating hypertension and preparation of traditional Chinese medicinal composition - Google Patents
Preparation methods of traditional Chinese medicinal composition for treating hypertension and preparation of traditional Chinese medicinal composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating hypertension. The traditional Chinese medicinal composition is prepared from 5 to 20 parts of gastrodia elata, 5 to 20 parts of rhizoma chuanxiong, 10 to 60 parts of spica prunellae, 10 to 40 parts of ramulus et uncus uncariae, 5 to 20 parts of radix salviae miltiorrhizae, 10 to 30 parts of radix puerariae and 3 to 12 parts of radix notoginseng. The dosage forms of the traditional Chinese medicinal composition comprise water decoction, powder, capsule, tablet, granule or pill. The traditional Chinese medicinal composition is low in pharmacy consumption and quick in effect; by clinical observation, the traditional Chinese medicinal composition is proved to have no toxic or side effects and achieve the aims of internal and external treatment and treatment of both manifestation and root cause of disease; the development of illness can be inhibited, and clinical symptoms can be relieved.
Description
Technical field
The present invention relates to the Chinese medicine composition of a kind of Hypertension and the preparation method of preparation thereof, belong to tcm field.
Background technology
Hypertension refers to increase with systemic arterial blood pressure (shrinking pressure and/or diastolic pressure) (shrink pressure >=140 millimetress of mercury, diastolic pressure >=90 millimetres of mercury) as principal character, can be with the function of the organs such as the heart, brain, kidney or the clinical syndrome of organic lesion.Hypertension is modal chronic disease, is also the topmost risk factor of cardiovascular and cerebrovascular disease.The blood pressure of normal person fluctuates within the specific limits with internal and external environment change.Overall crowd, blood pressure level gradually rose with the age, becomes apparent from shrinking pressure, but after 50 years old, diastolic pressure presents downward trend, and pulse pressure strengthens the most therewith.Hypertension be one gradual, by the cardiovascular disease caused by complicated and interrelated the cause of disease, it it is modal illness in cardiovascular disease, the development of hypertension has close relationship with functional and structural Cardiovascular abnormality, these can damage the heart extremely, kidney, cerebrovascular system and other organs, thus cause too early morbid state and death, estimate at present whole nation adult hypertension patient at least 1.6～2.0 hundred million, and Prevalence of Hypertension rises 25% in every 10 years, and the awareness of hypertension, treatment rate and control rate are the lowest, the purpose for the treatment of hypertension is not only in that and reduces blood pressure itself, also reside in prevalence and the case fatality rate of overall reduction cardiovascular diseases.At present, the Main Means for the treatment of hypertension is chemotherapy: such as valsartan capsule, No. 0 depressor in Beijing etc., although these medicines can make blood pressure return to normal value, but having certain side effect, long-term taking has certain hazardness to human body, uses by a definite limitation, prolonged application easily produces dependency, the unexpected drug withdrawal of prolonged application person can occur rebound phenomenon, not only increases dependency and the side effect of medicine, and curative effect is gradually reduced.The Chinese medicine preparation for the treatment of hypertension has compound recipe antelope angle hypertension pill, kendir pressure-reducing sheet, and feature is that curative effect is low, takes effect slow.
Summary of the invention
For the deficiencies in the prior art, the present invention provides a kind of good effect, the Chinese medicine composition that can replace depressor treatment hypertension and preparation method thereof.
Technical scheme is as follows:
The Chinese medicine composition of a kind of Hypertension, is made up of the raw material of following weight portion: Rhizoma Gastrodiae 5-20 part Rhizoma Chuanxiong 5-20 part Spica Prunellae 10-60 part Ramulus Uncariae Cum Uncis 10-40 part Radix Salviae Miltiorrhizae 5-20 part Radix Puerariae 10-30 part Radix Notoginseng 3-12 part.
Further preferred as technique scheme, the Chinese medicine composition of described Hypertension is made up of the raw material of following weight portion: 20 parts of Radix Salviae Miltiorrhizaes of 30 parts of Ramulus Uncariae Cum Unciss of 10 parts of Spica Prunellaes of 10 parts of Rhizoma Chuanxiongs of Rhizoma Gastrodiae, 15 portions of Radix Notoginseng of 10 parts of Radix Puerariaes 8 parts.
Described Chinese medicine composition dosage form is;Water decoction, unguentum, capsule, tablet, granule or watered pill.
According to the present invention, the preparation method of the Chinese medicinal composition preparation of a kind of Hypertension, comprise the following steps:
A. Rhizoma Gastrodiae, Rhizoma Chuanxiong, Spica Prunellae, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Radix Puerariae and panax mixed being pulverized, add 75% alcohol reflux 1-2 hour of 5-6 times amount volume, filter, take filtrate, filtering residue repeats backflow 2-3 time, merging filtrate, ethanol recovery；
B. step a gained filtrate is concentrated into relative density 80 DEG C and records the thick extractum of 1.20-1.25；
C. the thick extractum of step b is moved into baking oven, dries to moisture less than 5%, grind, obtain drug powder for 50-70 DEG C；
D. by the drug powder of step c, powder, capsule, tablet, granule or pill are made by prior art.
Above according to the present invention, the preparation method of the Chinese medicinal composition preparation of a kind of Hypertension, including taking each composition of raw material in proportion, mix, boiling 30 minutes, become water decoction.
In above material:
Rhizoma Gastrodiae: endogenous wind stopping, arresting convulsion.Controlling dizziness pupil, wind syndrome of head is had a headache, numb limbs and tense tendons, hemiplegia, aphasia, pediatric epilepsy scared wind symptom.There are calmness, analgesia, anticonvulsant action;Cerebral blood flow can be increased, reduce cerebral vascular resistance, light contraction cerebrovascular, increase coronary vasodilator flow;Can reduce blood pressure, decreased heart rate, effect protected to myocardial ischemia;Gastrodia elata polysaccharide has immunocompetence.For liver-wind dizziness, or the disease such as lack of preservation of spirit, insomnia forgetfulness.
Rhizoma Chuanxiong: have effect of blood-activating and qi-promoting, wind-expelling pain-stopping.For the menoxenia such as delayed menstrual cycle limit of stagnation of QI and blood, dysmenorrhea, amenorrhea, there is the effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, can be used for again experiencing headache, general pain and the rheumatic arthralgia etc. that ailment said due to cold or exposure (flu) causes.Therefore front person " gas medicine in blood ".
Spica Prunellae: heat clearing away eliminating stagnation.Cure mainly: scrofula, liver-fire ophthalmalgia, the disease such as hypertension.It is mainly used in heat clearing away (especially removing heat from the liver), eliminating stagnation etc..
Ramulus Uncariae Cum Uncis: heat clearing away suppressing the hyperactive liver；Relieving spasm by subduing liver-wind.For infantile convulsion；Night cry；Intenseness of heat wind symptom；Eclamposia；Dizziness due to hyperactivity of liver-YANG；Liver-fire distending pain in the head.Radix Salviae Miltiorrhizae: blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, the accumulation of abdominal mass abdominal mass, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, dysmenorrhea amenorrhea, skin infection swells and ache.Can be with nourishing blood to tranquillize the mind, modern pharmacological research, Radix Salviae Miltiorrhizae can be expanded blood vessel, improve circulatory disturbance sleeplessness of throbbing with fear and have the effect of improvement.For treating the diseases such as hypertension, atherosclerotic heart disease, angina pectoris, early stage liver cirrhosis, hyperlipemia, bronchial asthma.
Radix Puerariae: yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is quenched the thirst.For treating typhoid fever, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is impermeable, hypertension, angina pectoris, deaf.
Radix Notoginseng :Dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting blood, spit blood, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.
The pathogen and pathology of tcm of hypertension includes wind, fire, expectorant, void, the stasis of blood.
Wind: the cause of disease mostly is ponders over sorrow, psychentonia, impatience and irascibility causes stagnation of QI due to depression of the liver, if heat-transformation and extreme heat causing wind syndrome, the wind-yang and up-boring head, then has all diseases of headache, dizziness.
Fire: because bothering, overaction of the five emotions, then heat-transformation is lit a fire, and fire is contained, and water declines, it is impossible to system is fiery and contains wood, forms liver-fire and follows through the upper punch head, all diseases of hypertension occurs.
Expectorant: diet Sorghum vulgare Pers. savoury, the fertile gas of body is weak, and dyspepsia is not changed, poly-wet one-tenth expectorant, stagnation of turbid phlegm in middle-JIAO, checks the normal lifting of mechanism of qi, then raw in dizziness.
Empty: addiction is immoderate, and forced labour is impairment of the kidney, or fertility is too many, so that kidney water virtual loss, suffers from a deficiency of the kidney and can not go up liver nourishing wood, and liver-yang is recklessly acted without system, it is impossible to above holds heart-fire, then becomes all diseases such as disarmony between the heart and kidney.
The stasis of blood: with the passing of time, or obstinate i.e. may result in the generation of blood stasis to the course of disease, and the deficiency of vital energy, liver-fire, stagnation of phlegm etc. all can become the cause of disease of syndrome of blood stasis.
The present invention appliesRadix Notoginseng, Radix Salviae Miltiorrhizae promoting blood circulation to remove blood stasis, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver eliminate the phlegm；Relieving spasm by subduing liver-wind.Spica Prunellae heat clearing away eliminating stagnation, Radix Puerariae yang invigorating qi-restoratives.Rhizoma Chuanxiong blood-activating and qi-promoting dispels the wind.The present invention is directed to the tcm causa morbi wind of hypertension, fire, expectorant, void, stasis of blood treatment.The present invention compared with prior art has the advantage that monarch of the present invention, minister, helps, makes respectively to execute its effect, has medication few, instant effect, and clinical observation card is to have no side effect, and can reach inside and outside double execute, the purpose for the treatment of both the principal and secondary aspects of a disease.Can suppress the development of the state of an illness, alleviate clinical symptoms, therapeutic effect is good.Without the toxic and side effects of chemicals, can long-term taking.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1A kind of Chinese medicine composition of Hypertension, described Chinese medicine composition is made up of the raw material of following weight portion:
20 parts of Radix Salviae Miltiorrhizaes of 30 parts of Ramulus Uncariae Cum Unciss of 10 parts of Spica Prunellaes of 10 parts of Rhizoma Chuanxiongs of Rhizoma Gastrodiae, 15 portions of Radix Notoginseng of 10 parts of Radix Puerariaes 8 parts.
Preparation method, comprises the following steps:
A. Rhizoma Gastrodiae, Rhizoma Chuanxiong, Spica Prunellae, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Radix Puerariae and panax mixed being pulverized, add 75% alcohol reflux 1-2 hour of 5-6 times amount volume, filter, take filtrate, filtering residue repeats backflow 2-3 time, merging filtrate, ethanol recovery；
B. step a gained filtrate is concentrated into relative density 80 DEG C and records the thick extractum of 1.20-1.25；
C. the thick extractum of step b is moved into baking oven, dries to moisture less than 5%, grind, obtain drug powder for 50-70 DEG C；
D. by the drug powder of step c, capsule is made by prior art.
Embodiment 2
The Chinese medicine composition of a kind of Hypertension, is made up of the raw material of following weight portion: 10 parts of Radix Salviae Miltiorrhizaes of 10 parts of Ramulus Uncariae Cum Unciss of 5 parts of Spica Prunellaes of 5 parts of Rhizoma Chuanxiongs of Rhizoma Gastrodiae, 10 portions of Radix Notoginseng of 5 parts of Radix Puerariaes 3 parts.
Preparation method is with embodiment 1.
Embodiment 3
The Chinese medicine composition of a kind of Hypertension, is made up of the raw material of following weight portion: 40 parts of Radix Salviae Miltiorrhizaes of 60 parts of Ramulus Uncariae Cum Unciss of 20 parts of Spica Prunellaes of 20 parts of Rhizoma Chuanxiongs of Rhizoma Gastrodiae, 30 portions of Radix Notoginseng of 20 parts of Radix Puerariaes 12 parts.
Preparation method is with embodiment 1.
Contrast test:
The present invention includes the standard for the treatment of in: the treatment that the present invention choosesHypertensionDiagnostic criteria and typing:
The criterion of therapeutical effect of hypertension: include by adding up curative effect and by symptom statistics curative effect by stages:
By adding up curative effect by stagesInclude in1 grade of hypertension (slightly) and 2 grades of hypertension (moderate) are treatment criterion of therapeutical effect.
Curative effect is added up by symptomInclude inDizzy, headache, neck plate are tight, fatigue, cardiopalmus, the hypertension such as uncomfortable in chest, weak clinical symptoms for treating criterion of therapeutical effect.
Curative effect determinate standard (by the statistics curative effect by stages of hypertension):
Effective: (1) diastolic pressure declines more than 10mmHg and reaches normal range.(2) though diastolic pressure does not drops to normally, but more than 20mmHg has been declined.
Effective: (1) diastolic pressure declines not as good as 10mmHg but reached normal range.(2) decline 10-1mmHg before diastolic pressure is relatively treated, but not up to normal range.(3) more than 30mmHg is declined before shrinking pressure relatively treatment.
The most invalid: not up to above standard person.
Curative effect determinate standard (adds up curative effect by the symptom of hypertension):
Effective: the wholly or largely transference cure of case or be obviously improved after treatment.
Effective: after treatment transference cure or the case that is obviously improved reach half or more than, but the most effective standard.
Slight effectively: after treatment, transference cure or the case that is obviously improved not as good as half but have met or exceeded 1/3.
The most invalid: not up to above standard person.
Choose the hyperpietic of 200 examples, randomly select 150 examples as treatment group, other 50 examples are as a control group, wherein 150 example patients are divided into treatment group 1, treatment group 2 and treatment group 3, each treatment group treats the 50 example patients randomly selected, the capsule that treatment group 1 uses the embodiment of the present invention 1 to prepare is treated, and the capsule that treatment group 2 uses the embodiment of the present invention 2 to prepare is treated, and the capsule that treatment group 3 uses the embodiment of the present invention 3 to prepare is treated.Matched group 50 example application kendir pressure-reducing sheet is treated.One time 5,3 times on the one.Finally by statistics by stages and the symptom Statistic analysis efficacy result of hypertension:
By the statistics curative effect by stages of hypertension:
Therapeutic outcome such as following table:
From data above table it can be seen that treatment group effective percentage is higher than remaining treatment group 3 apparently higher than matched group, the effective percentage for the treatment of group 1 and 2, treatment group in sum 1 and 2 prescription is maximally efficient.
By the symptom statistics curative effect of hypertension:
Claims (4)
1. a Chinese medicine composition for Hypertension, is characterized in that: described Chinese medicine composition is made up of the raw material of following weight portion:
Rhizoma Gastrodiae 5-20 part, Rhizoma Chuanxiong 5-20 part, Spica Prunellae 10-60 part, Ramulus Uncariae Cum Uncis 10-40 part, Radix Salviae Miltiorrhizae 5-20 part, Radix Puerariae 10-30 part, Radix Notoginseng 3-12 part.
2. the Chinese medicine composition of Hypertension as claimed in claim 1, is characterized in that: described Chinese medicine composition is made up of the raw material of following weight portion:
10 parts of Rhizoma Gastrodiae, Rhizoma Chuanxiong 10 parts, Spica Prunellae 30 parts, Ramulus Uncariae Cum Uncis 20 parts, Radix Salviae Miltiorrhizae 10 parts, Radix Puerariae 15 parts,
Radix Notoginseng 8 parts.
3. the preparation method of the Chinese medicinal composition preparation of Hypertension as claimed in claim 1 or 2, is characterized in that: the preparation method of described Chinese medicine composition comprises the following steps:
A. Rhizoma Gastrodiae, Rhizoma Chuanxiong, Spica Prunellae, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Radix Puerariae and panax mixed being pulverized, add 75% alcohol reflux 1-2 hour of 5-6 times amount volume, filter, take filtrate, filtering residue repeats backflow 2-3 time, merging filtrate, ethanol recovery；
b.
Step a gained filtrate is concentrated into relative density 80 DEG C and records the thick extractum of 1.20-1.25；
C. the thick extractum of step b is moved into baking oven, dries to moisture less than 5%, grind, obtain drug powder for 50-70 DEG C；
D. by the drug powder of step c, powder, capsule, tablet, granule or pill are made by prior art.
4. the Chinese medicine composition of Hypertension as claimed in claim 1 or 2, is characterized in that: the dosage form of described Chinese medicine composition is: water decoction, powder, capsule, tablet, granule or pill.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110711235A (en) * | 2019-09-02 | 2020-01-21 | 王太国 | Tianshen blood pressure reducing capsule for calming liver, stopping endogenous wind, dredging collaterals, promoting qi circulation, activating blood circulation and removing blood stasis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110711235A (en) * | 2019-09-02 | 2020-01-21 | 王太国 | Tianshen blood pressure reducing capsule for calming liver, stopping endogenous wind, dredging collaterals, promoting qi circulation, activating blood circulation and removing blood stasis |
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