CN105998756A - Medicament for treating hypertension and coronary heart disease and preparation method of medicament - Google Patents

Medicament for treating hypertension and coronary heart disease and preparation method of medicament Download PDF

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CN105998756A
CN105998756A CN201610590595.XA CN201610590595A CN105998756A CN 105998756 A CN105998756 A CN 105998756A CN 201610590595 A CN201610590595 A CN 201610590595A CN 105998756 A CN105998756 A CN 105998756A
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parts
radix
rhizoma
vitamin
heart disease
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王晨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
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    • A61K35/56—Materials from animals other than mammals
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Abstract

The invention relates to a medicament for treating hypertension and coronary heart disease. The medicament is prepared from the following materials in parts by weight: 30 to 60 parts of radix puerariae, 60 to 90 parts of radix notoginseng, 100 to 150 parts of radix et rhizoma rhei, 30 to 60 parts of radix scutellariae, 30 to 60 parts of gastrodia elata, 15 to 30 parts of South Africa leaves, 60 to 90 parts of spanishneedles herb, 60 to 90 parts of radix salviae miltiorrhizae, 30 to 60 parts of radix cyathulae, 60 to 120 parts of raw fructus crataegi, 60 to 90 parts of American ginseng, 60 to 90 parts of noble dendrobium, 10 to 15 parts of scorpion, 15 to 30 parts of centipede, 30 to 60 parts of radix polygalae, 30 to 60 parts of rhizoma acori graminei, 30 to 60 parts of rhizome or root of incised notopterygium, 30 to 60 parts of tribulus terrestris, 60 to 90 parts of motherwort herb, 30 to 60 parts of pearl, 60 to 90 parts of bighead atractylodes rhizome, 120 to 180 parts of rhizoma alismatis, 60 to 90 parts of poria cocos, 30 to 90 parts of rhizoma dioscoreae, 90 to 120 parts of auricularia auricular, 30 to 90 parts of phellinus igniarius, 30 to 60 parts of pollen typhae, 30 to 90 parts of roughhaired holly root, 30 to 90 parts of rose glory-bower root, 0.015 to 0.03 part of vitamin B9, 0.3 to 0.9 part of vitamin B6 and 0.01 to 0.018 part of vitamin B12.

Description

A kind of medicine treating hypertension, coronary heart disease and preparation method thereof
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of treat hypertension, the medicine of coronary heart disease and preparation side thereof Method.
Background technology
Due to growth in the living standard, the technicalization of labor style, hypertension, hyperlipidemia are a kind of common at society Sick, frequently-occurring disease, covers youth from old age, has the tendency that gradually becomes younger.Hypertension is mainly row's blood of heart because of the body circulating cycle Enclosing vascular resistance to increase, blood circulation makes systemic arterial blood pressure fluctuate in certain scope under the effect of internal and external environment. Acute high voltage adjusting mainly under central nervous system's control by being positioned at blood aortic arch, the arterial pressure in carotid sinus bulb The reflection pressure activity of ergoreceptor and realize.Chronic regulation is the most complex.And cut blood pressure level and also gradually increase with the age And increase, it is obvious to shrink pressure.I thinks that being probably the silt of the finest channels atrophy spasm hinders, and blood circulation produces obstacle, from Energy (oxygen) required for body art tip organ is not enough, the regulation power increasing of self nervus centralis just must could maintain peripheral blood Often circulation, clinical blood pressure of just cashing out raises.Hyperlipidemia is mainly the content of cholesterol and triglyceride and exceeds normal range, faces Bed can be divided into constitutional and Secondary cases two class.In Patients With Primary Hyperlipoidemia major part is that the edible high lipid of excess becomes with carbohydrate Too high food is divided to cause.It addition, major part is by caused by lipid and lipoprotein metabolism birth defect.Still belong to unknown machine at present Making rises and (is probably the endocrine regulation such as bilirubin and digestive enzyme, it is impossible to become hepatic glycogen again hepatic glycogen all kinds of adipose conversion Changing into heat, human body activity can not consume fat metabolism matter, and accumulates the hyperlipidemia being to cause in blood.Secondary cases is high Blood fat disease be secondary to more obstruction of bile duct inside and outside diabetes myxedema, the nephrotic syndrome, pancreatitis, cardiovascular and cerebrovascular disease, liver, Hepatic glycogen hemachromatosis.
Summary of the invention
It is an object of the invention to provide a kind of medicine treating hypertension, coronary heart disease and preparation method thereof.
In order to realize the purpose of the present invention, the present invention provides a kind of medicine treating hypertension, coronary heart disease, and it comprises following The material of weight portion: Radix Puerariae 30-60 part, Radix Notoginseng 60-90 part, Radix Et Rhizoma Rhei 100-150 part, Radix Scutellariae 30-60 part, Rhizoma Gastrodiae 30-60 part, south N omicronn-leaf 15-30 part, Herba Bidentis Bipinnatae 60-90 part, Radix Salviae Miltiorrhizae 60-90 part, Radix Cyathulae 30-60 part, Fructus Crataegi 60-120 part, Radix Panacis Quinquefolii 60- 90 parts, Herba Dendrobii 60-90 part, Scorpio 10-15 part, Scolopendra 15-30 part, Radix Polygalae 30-60 part, Rhizoma Acori Graminei 30-60 part, Rhizoma Et Radix Notopterygii 30-60 Part, Fructus Atriplicis Sibiricae 30-60 part, Herba Leonuri 60-90 part, Margarita 30-60 part, Rhizoma Atractylodis Macrocephalae 60-90 part, Rhizoma Alismatis 120-180 part, Poria 60- 90 parts, Rhizoma Dioscoreae 30-90 part, Auricularia 90-120 part, Phellinus igniarius (L. ex Fr.) Quel. 30-90 part, Pollen Typhae 30-60 part, Radix Ilicis Asprellae 30-90 part, Caulis et folium clerodendri bungei Root 30-90 part, FA 0.015-0.03 part, vitamin B6 0.3-0.9 part and vitamin B12 0.01-0.018 part.
Preferably, treatment hypertension of the present invention, coronary heart disease pharmaceutical pack containing the material of following weight portion: Radix Puerariae 45 Part, Radix Notoginseng 75 parts, Radix Et Rhizoma Rhei 120 parts, Radix Scutellariae 45 parts, 45 parts of Rhizoma Gastrodiae, 20 parts of South Africa leaf, Herba Bidentis Bipinnatae 75 parts, Radix Salviae Miltiorrhizae 75 parts, Radix Cyathulae 45 parts, Fructus Crataegi 80 parts, Radix Panacis Quinquefolii 75 parts, Herba Dendrobii 75 parts, Scorpio 12 parts, Scolopendra 20 parts, Radix Polygalae 45 parts, Rhizoma Acori Graminei 45 parts, Qiang Live 45 parts, Fructus Atriplicis Sibiricae 45 parts, Herba Leonuri 75 parts, Margarita 45 parts, the Rhizoma Atractylodis Macrocephalae 75 parts, Rhizoma Alismatis 150 parts, Poria 75 parts, Rhizoma Dioscoreae 60 parts, black 100 parts of Auricularia, Phellinus igniarius (L. ex Fr.) Quel. 60 parts, Pollen Typhae 45 parts, Radix Ilicis Asprellae 60 parts, Radix clerodendri bungei 60 parts, FA 0.02 part, vitamin B6 0.5 part and vitamin B12 0.015 part.
It is highly preferred that treatment hypertension of the present invention, the medicine of coronary heart disease also comprise: 0.2 part there is following knot The material of structure formula:
Preferably, described Chinese medicine composition can be lotion, ointment or powder.
The present invention also provides for the use in the medicine of hypertension, coronary heart disease is treated in preparation of the material with following structural On the way:
Medicine of the present invention has suppressing the hyperactive liver to dispel the wind, clearing away damp-heat, blood pressure reduction effect, is used for treating vascular hypertension and has therapeutic effect Good, expense is low, instant, the advantage having no side effect.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustrating The present invention rather than limitation of the present invention.The simple modifications that the present invention is carried out by the essence according to the present invention broadly falls into the present invention Claimed scope.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment 1
Weigh Radix Puerariae 45 grams, Radix Notoginseng 75 grams, Radix Et Rhizoma Rhei 120 grams, Radix Scutellariae 45 grams, 45 grams of Rhizoma Gastrodiae, 20 grams of South Africa leaf, Herba Bidentis Bipinnatae 75 Gram, Radix Salviae Miltiorrhizae 75 grams, Radix Cyathulae 45 grams, Fructus Crataegi 80 grams, Radix Panacis Quinquefolii 75 grams, Herba Dendrobii 75 grams, Scorpio 12 grams, Scolopendra 20 grams, Radix Polygalae 45 grams, Rhizoma Acori Graminei 45 grams, Rhizoma Et Radix Notopterygii 45 grams, Fructus Atriplicis Sibiricae 45 grams, Herba Leonuri 75 grams, Margarita 45 grams, the Rhizoma Atractylodis Macrocephalae 75 grams, Rhizoma Alismatis 150 grams, Fu A kind of reed mentioned in ancient books 75 grams, Rhizoma Dioscoreae 60 grams, Auricularia 100 grams, Phellinus igniarius (L. ex Fr.) Quel. 60 grams, Pollen Typhae 45 grams, Radix Ilicis Asprellae 60 grams, Radix clerodendri bungei 60 grams, vitamin B9 0.02 gram, vitamin B6 0.5 gram and vitamin B12 0.015 gram, pulverize, and crosses 100 mesh sieves, and mix homogeneously obtains powder.
Embodiment 2
Compound has a following structural:
Experimental example
Take SPF level SD rat 60, male and female half and half, leave and take 10 rats (male and female half and half) at random as Normal group, Remaining 50 rat is as modeling group.After modeling group rat is with chloral hydrate (0.4ml/100g) intraperitoneal injection of anesthesia of 10% Rat lies on the back and is fixed on operating-table, cuts off abdominal part chaeta, 5% iodophor disinfection, and 75% ethanol takes off iodine, covers hole towel.Along abdomen just The center line otch that operates opens abdominal cavity, and by sterile working, careful blunt separation goes out left renal artery, penetrates chorda serica chirurgicalis sterilis, diameter Acupuncture needle for 0.25mm is close to be placed in parallel with renal artery blood vessel major axis, takes out after tightening renal artery and acupuncture needle with chorda serica chirurgicalis sterilis Going out acupuncture needle, result causes unilateral renal artery stenosis, offside kidney and tremulous pulse not to touch.Rats in normal control group is except not ligaturing kidney Outside tremulous pulse, remaining operation technique the most ibid, as sham operated rats.Postoperative continuous 3d lumbar injection penicillin (3 × 104U/d) pre- Anti-infection.Each treated animal is the most normally raised.
Modeling rat 50, Etomidate 100mg kg is taken after modeling 10w-1Intraperitoneal injection of anesthesia, BP-100A is complete certainly Dynamic rat non-invasive blood pressure is measured system tail sleeve method and is measured each modeling rat blood pressure, as Hypertensive Rats blood pressure number before being administered Value.It is divided into 5 groups, respectively model control group, Captopril group, administration group 1, administration group 2 and administration group 3 by blood pressure values, Often group 10, male and female half and half.Its blood pressure is measured, before being administered with method anesthesia Normal group (sham operated rats) rat tail sleeve method Normal rat blood pressure values.
Each group dosage is as follows: sham operated rats and model group, gives normal saline gavage 1mL/100g body weight；Captopril Group, captopril 0.2g adds 100mL normal saline and becomes suspension, gives gavage 1mL/100g body weight；Administration group 1, implements The powder 10g of example 1 adds 1000mL normal saline and becomes suspension, gives gavage 1mL/100g body weight；Administration group 2,0.02g's The compound of embodiment 2 adds 1000mL normal saline and becomes suspension, gives gavage 1mL/100g body weight；Administration group 3, implements The compound of the embodiment 2 of powder 5g with 0.01g of example 1 adds 1000mL normal saline and becomes suspension, gives gavage 1mL/ 100g body weight.Every day 1 time, continuous 4w.Result see table.
Group Shrink pressure (mmHg) Diastolic pressure (mmHg)
Sham operated rats 121.31±5.16 76.21±3.26
Model group 159.16±8.01 119.16±4.51
Captopril group 130.26±6.33 90.53±3.69
Administration group 1 140.43±6.92 99.72±3.95
Administration group 2 135.62±6.55 93.13±3.72
Administration group 3 138.89±6.81 96.25±3.81

Claims (5)

1. the medicine treating hypertension, coronary heart disease, it is characterised in that it comprises the material of following weight portion: Radix Puerariae 30-60 Part, Radix Notoginseng 60-90 part, Radix Et Rhizoma Rhei 100-150 part, Radix Scutellariae 30-60 part, Rhizoma Gastrodiae 30-60 part, South Africa leaf 15-30 part, Herba Bidentis Bipinnatae 60- 90 parts, Radix Salviae Miltiorrhizae 60-90 part, Radix Cyathulae 30-60 part, Fructus Crataegi 60-120 part, Radix Panacis Quinquefolii 60-90 part, Herba Dendrobii 60-90 part, Scorpio 10-15 part, Scolopendra 15-30 part, Radix Polygalae 30-60 part, Rhizoma Acori Graminei 30-60 part, Rhizoma Et Radix Notopterygii 30-60 part, Fructus Atriplicis Sibiricae 30-60 part, Herba Leonuri Grass 60-90 part, Margarita 30-60 part, Rhizoma Atractylodis Macrocephalae 60-90 part, Rhizoma Alismatis 120-180 part, Poria 60-90 part, Rhizoma Dioscoreae 30-90 part, black wood Ear 90-120 part, Phellinus igniarius (L. ex Fr.) Quel. 30-90 part, Pollen Typhae 30-60 part, Radix Ilicis Asprellae 30-90 part, Radix clerodendri bungei 30-90 part, FA 0.015-0.03 part, vitamin B6 0.3-0.9 part and vitamin B12 0.01-0.018 part.
Treatment hypertension the most according to claim 1, the medicine of coronary heart disease, it is characterised in that it comprises following weight portion Material: Radix Puerariae 45 parts, Radix Notoginseng 75 parts, Radix Et Rhizoma Rhei 120 parts, Radix Scutellariae 45 parts, 45 parts of Rhizoma Gastrodiae, 20 parts of South Africa leaf, Herba Bidentis Bipinnatae 75 parts, red Join 75 parts, Radix Cyathulae 45 parts, Fructus Crataegi 80 parts, Radix Panacis Quinquefolii 75 parts, Herba Dendrobii 75 parts, Scorpio 12 parts, Scolopendra 20 parts, Radix Polygalae 45 parts, Rhizoma Acori Graminei 45 parts, Rhizoma Et Radix Notopterygii 45 parts, Fructus Atriplicis Sibiricae 45 parts, Herba Leonuri 75 parts, Margarita 45 parts, the Rhizoma Atractylodis Macrocephalae 75 parts, Rhizoma Alismatis 150 parts, Poria 75 Part, Rhizoma Dioscoreae 60 parts, Auricularia 100 parts, Phellinus igniarius (L. ex Fr.) Quel. 60 parts, Pollen Typhae 45 parts, Radix Ilicis Asprellae 60 parts, Radix clerodendri bungei 60 parts, FA 0.02 part, vitamin B6 0.5 part and vitamin B12 0.015 part.
Treatment hypertension the most according to claim 2, the medicine of coronary heart disease, it is characterised in that it also comprises: 0.2 part There is the material of following structural:
Treatment hypertension the most according to claim 3, the medicine of coronary heart disease, it is characterised in that described Chinese medicine composition can To be lotion, ointment or powder.
5. have the material of following structural preparation treatment hypertension, coronary heart disease medicine in purposes:
CN201610590595.XA 2016-07-26 2016-07-26 Medicament for treating hypertension and coronary heart disease and preparation method of medicament Withdrawn CN105998756A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107198731A (en) * 2017-08-01 2017-09-26 毛里夏里甫·哈帕 It is a kind of to treat hypertension, medicine of cerebral infarction and preparation method thereof and application method

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103550480A (en) * 2013-11-15 2014-02-05 晏秀玲 Chinese herbal preparation for treating coronary heart disease complicated with hypertension
CN103610948A (en) * 2013-12-06 2014-03-05 山东省立医院 Traditional Chinese medicine composition for treating hypertension
CN105055915A (en) * 2015-07-17 2015-11-18 山东方健制药有限公司 Traditional Chinese medicine composition for treating hypertension
CN105079577A (en) * 2015-09-24 2015-11-25 谢志明 Traditional Chinese medicine composition for treating hypertension and preparing method thereof
CN105687619A (en) * 2014-11-28 2016-06-22 魏丽华 Traditional Chinese medicine for treating coronary heart disease

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103550480A (en) * 2013-11-15 2014-02-05 晏秀玲 Chinese herbal preparation for treating coronary heart disease complicated with hypertension
CN103610948A (en) * 2013-12-06 2014-03-05 山东省立医院 Traditional Chinese medicine composition for treating hypertension
CN105687619A (en) * 2014-11-28 2016-06-22 魏丽华 Traditional Chinese medicine for treating coronary heart disease
CN105055915A (en) * 2015-07-17 2015-11-18 山东方健制药有限公司 Traditional Chinese medicine composition for treating hypertension
CN105079577A (en) * 2015-09-24 2015-11-25 谢志明 Traditional Chinese medicine composition for treating hypertension and preparing method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107198731A (en) * 2017-08-01 2017-09-26 毛里夏里甫·哈帕 It is a kind of to treat hypertension, medicine of cerebral infarction and preparation method thereof and application method

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Application publication date: 20161012