CN105998661A - Traditional Chinese medicine composition and preparation method thereof - Google Patents
Traditional Chinese medicine composition and preparation method thereof Download PDFInfo
- Publication number
- CN105998661A CN105998661A CN201610563081.5A CN201610563081A CN105998661A CN 105998661 A CN105998661 A CN 105998661A CN 201610563081 A CN201610563081 A CN 201610563081A CN 105998661 A CN105998661 A CN 105998661A
- Authority
- CN
- China
- Prior art keywords
- time
- extracting solution
- filtrate
- weight
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention provides a traditional Chinese medicine composition and a preparation method thereof. The traditional Chinese medicine composition is used for treating hyperlipidemia and reducing blood lipids. Compared with the prior art, the raw materials in the invention are mutually cooperated and used together; the prepared oral liquid not only can reduce blood lipids and blood sugar, but also can relieve hyperlipidemia and hyperglycemia-induced complications, improves the treatment effect, improves the immunity and health of users, is fast to take effect and has good effect.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of Chinese medicine composition and preparation method thereof.
Background technology
Hyperlipemia is referred to as hyperlipemia, refer in the blood plasma that a variety of causes causes cholesterol and/
Or triglyceride levels raises.Lipid in blood plasma, in addition to cholesterol and triglyceride, also includes
Phospholipid, glycolipid, sterin and steroid, be widely present in during human body respectively organizes, and they are cells
The required material of basal metabolism.
There are two parts in the source of blood fat: external source and endogenous.External source refers to that the lipid in food is through disappearing
Changing absorbed into serum, the latter is the lipid that internal synthetic tissue mobilizes out.The outlet of blood fat is
Constantly absorbed by tissue or as energy storage, or as oxidized energy supply or composition biomembrane
And other materials.
The directly infringement of hyperlipemia is to accelerate systemic atherosclerosis, because the weight of whole body
Wanting organ will rely on tremulous pulse blood supply, oxygen supply, once tremulous pulse is blocked by atheromatous plaque, will lead
Cause a series of serious consequence.The renal failure that atherosclerosis causes etc. all with hyperlipemia
Closely related.Numerous studies data shows, hyperlipemia is apoplexy, coronary heart disease, cardiac muscle stalk
The important risk factor of disease of waiting indefinitely.
Additionally, hyperlipemia is also to promote hypertension, impaired glucose tolerance, a weight of diabetes
Want risk factor.Hyperlipemia can also result in fatty liver, liver cirrhosis, cholelithiasis, pancreatitis,
Retinal hemorrhage or even blind, peripheral angiopathy, hyperuricemia.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition and preparation method thereof, be used for treating
Hyperlipemia, reduces blood fat.
A kind of Chinese medicine composition that the present invention provides, containing the raw material of following weight portion:
The preparation method of described ginseng extract is:
The Radix Ginseng of purchase is pulverized, adds the ethanol of the volume fraction 80% of 6-7 times of weight
Heating and refluxing extraction 3-4 time, each 0.8-1.5h；Merging filtrate, drying under reduced pressure, prepare
Ginseng extract.
The preparation method of described Poria extracting solution is:
Poria is dried after pulverizing, cross 40-60 mesh sieve, add the water of 50-60 times amount, ultrasonic
Extract 25-30min；Filter, obtain filtrate, be concentrated into the 3-6g/ml of Poria weight.
The preparation method of described Cordyceps extracting solution is:
Cordyceps is pulverized, heating extraction 3 times, add the water of 5-7 times of weight at 65-70 DEG C for the first time
Lower extraction 1.5-2h；Second time adds 4-6 times amount water, extracts 0.5-1.5h at 68-70 DEG C, the
Adding 3-5 times amount water for 3 times, 65-70 DEG C is extracted 0.5-1.5h, filters, merging filtrate every time,
The volume concentration of filtrate, to 3-6 times of g/ml of Cordyceps weight, obtains Cordyceps extracting solution.
The preparation method of described Rhizoma Polygonati extracting solution is:
Rhizoma Polygonati is pulverized, crosses 20-40 mesh sieve, after petroleum ether 80-90 DEG C backflow defat, add
Heat is extracted 3 times, and the water adding 10-18 times of weight for the first time extracts 1.5-2h at 90-95 DEG C；
Second time adds 10-15 times amount water and extracts 0.5-1.5h at 85-90 DEG C, adds 8-12 times the 3rd time
Amount water extracts 0.5-1.5h at 85-90 DEG C, filters, merging filtrate every time, and the volume of filtrate is dense
It is reduced to 3-6 times of g/ml of Cordyceps weight, obtains Rhizoma Polygonati extracting solution.
The preparation method of described Herba Cistanches extracting solution is:
Being pulverized by Herba Cistanches, heating extraction 3 times, the water adding 10-12 times of weight for the first time exists
1.5-2h is extracted at 80-85 DEG C；Second time adds 8-10 times amount water 85-90 DEG C of extraction
0.5-1.5h, adds 6-8 times amount water for the 3rd time and extracts 0.5-1h at 85-90 DEG C, filter every time,
Merging filtrate, 4-6 times of g/ml of the volume concentration of filtrate to Herba Cistanches weight, obtain meat desert
Rong's extracting solution.
The preparation method of described Folium Crataegi extracting solution:
Weigh Folium Crataegi, add the distilled water of 15-20 times amount, the cellulase of 0.2-0.4% and
The pectase of 0.2-0.4%, with hydrochloric acid tune pH value to 4-5,45-55 DEG C of vibrating at constant temperature for enzymolysis
100-150min, first destroys Folium Crataegi cell wall, extracts at being then warmed up to 85-90 DEG C
60-90min；After being cooled to room temperature, centrifugation, obtain supernatant；Residue Folium Crataegi residue is used
80-90 DEG C of water washs 1 time, and centrifugation obtains cleaning mixture；2 supernatant are merged, concentrates
To 4-6 times of g/ml of Folium Crataegi weight, obtain Folium Crataegi extracting solution.
The preparation method of described Semen Cassiae extracting solution is:
By Semen Cassiae 8-10 times of alcohol reflux 3-4 time, extract 1-2h every time；Residue
After ethanol is removed in volatilization, the water extraction of addition 8-10 times of weight of residue 2-3 time, extracts every time
1-2h；After filtration, it is 1-1.5g/mL that filtrate is concentrated into density, obtains Semen Cassiae extracting solution.
The preparation method of described Semen Ginkgo extrac is:
Dry Semen Ginkgo was pulverized 40-60 mesh sieve, with ethanol ultrasonic extraction 2 times, added for the first time
The ethanol of the volume fraction 90% of 10-20 times, extracts 1-2h at 70 DEG C under 400W power；
Second time is at the ethanol of the volume fraction 75% of 10-15 times, at 60-70 DEG C under 300W power
Extract 1-2h, merging filtrate, concentrating under reduced pressure, obtain Semen Ginkgo extrac.
The preparation method of described Radix Oenotherae erythrosepalae extract is:
Radix Oenotherae erythrosepalae pulverized 40-60 mesh sieve, by the second of the volume fraction 80% of 25-30 times of weight
Alcohol heats 80-90 DEG C, reflux, extract, 2 times, and each merging filtrate, after concentration, adds 3-4
The ethanol remove impurity of the volume fraction 95% of times volume, centrifugal after, obtain filtrate, filtrate is concentrated to give
Radix Oenotherae erythrosepalae extract.
The preparation method of described Rhizoma Chuanxiong extracting solution is:
Rhizoma Chuanxiong is pulverized, heating extraction 2 times, add 8-11 times amount water at 70-90 DEG C for the first time
Extracting 0.5-2h, second time adds 6-8 times amount water and extracts 0.5-1h at 85-95 DEG C, filters every time
Cross, merging filtrate, 4-6 times of g/ml of the volume concentration of filtrate to Rhizoma Chuanxiong weight, obtain river
Vault extracting solution.
The preparation method of described Folium Nelumbinis extract is:
Folium Nelumbinis is dried, pulverizes, cross 100-160 mesh sieve, add the ethanol of volumetric concentration 60%,
Soak 10-12h, the second of the volumetric concentration 75% of 40-45 times of weight of the Lotus Leaf after immersion
Alcohol supersound extraction 20-25min, filtrate concentrate drying, obtain Folium Nelumbinis extract.
The preparation method of described Radix Puerariae extracting solution is:
Being pulverized by Radix Puerariae, heating extraction 3 times, the water adding 25-30 times of weight for the first time exists
1.5-2h is extracted at 80-95 DEG C；Second time adds 15-25 times amount water, extracts at 80-90 DEG C
0.5-1.5h, adds 25-28 times amount water for the 3rd time, and 80-90 DEG C is extracted 0.5-2h, filter every time,
Merging filtrate, 3-6 times of g/ml of the volume concentration of filtrate to Radix Puerariae weight, obtain Radix Puerariae and carry
Take liquid.
The preparation method of described chrysanthemum extract liquid is:
Weigh Flos Chrysanthemi appropriate, reflux, extract, twice, add 6-15 times amount water for the first time, soak super
Sound 0.5-1h, extracts 0.5-2h, filters, and second time adds 6-15 times amount water, extracts 0.5-2h,
Filtering, twice filtrate merges, and the volume concentration of filtrate is 5-15 times of g/ml of Flos Chrysanthemi weight,
Obtain chrysanthemum extract liquid.
The preparation method of described Folium Psidii Guajavae extracting solution is:
Weigh Folium Psidii Guajavae appropriate, heating extraction twice, add 5-10 times amount water for the first time, add
Heat decocts to 80-90 DEG C, extracts 0.5-2h, filters, and second time adds 6-8 times amount water, heating
To 85-90 DEG C, extracting 0.5-2h, filter, twice filtrate merges, and the volume concentration of filtrate is
5-15 times of g/ml of Flos Chrysanthemi weight, obtains Folium Psidii Guajavae extracting solution.
The preparation method of a kind of Chinese medicine composition that the present invention provides, comprises the following steps:
(1) ginseng extract in formula, Poria extracting solution, Cordyceps extracting solution, Rhizoma Polygonati are extracted
Liquid, Herba Cistanches extracting solution, haw liquid extracting solution, Semen Cassiae extracting solution, Folium Ginkgo extract,
Radix Oenotherae erythrosepalae extracting solution, Rhizoma Chuanxiong extracting solution, Folium Nelumbinis extract, Radix Puerariae extracting solution, chrysanthemum extract liquid,
Folium Psidii Guajavae extracting solution and water are heated to 50-70 DEG C, stirring and evenly mixing；
(2) after cooling, adding the potassium sorbate of formula ratio, malic acid and CMC, stirring is mixed
Even, obtain Chinese medicine composition.
The acting as of each raw material in the present invention:
Radix Ginseng is the dry root of Araliaceae Radix Ginseng.Have that the multiple arteries and veins of strongly invigorating primordial QI is admittedly de-, spleen reinforcing
Lung benefiting, the effect promoted the production of body fluid, calm the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, lung
Dyspnea due to deficiency is coughed, Tianjin wound thirsty, interior-heat is quenched one's thirst, prolonged illness void is won, palpitation with fear insomnia, sexual impotence cold womb, the heart
Force failure, cardiogenic shock etc..Ginsenoside mostly has increase quantity of leucocyte, improves people
Body immunity, promotion substance metabolism, resisting fatigue, the anti-ageing effect of waiting for a long time.The design of extraction process
By the method that active component and drug effect combine is made Chinese medicine extraction product, with Semen Ginkgo, meat desert
The compatibilities such as Rong, its curative effect in terms for the treatment of hyperlipidemia prominent.
The effects such as Poria has with fixed attention, spleen invigorating, promoting diuresis to eliminate damp pathogen, it is possible to regulation function of immune system,
Antitumor, slow down aging, prevent and treat the effect such as calculus.Ultrasonic wave added method is utilized to extract Poria effective
Composition, controls solid-liquid ratio and the mesh number of polysaccharide pulverizing, improves extraction efficiency, obtaining higher containing
Ensure that drug effect is best on the basis of amount active component.
Containing multiple lifes such as cordycepin, cordycepic acid, Cordyceps polysaccharide, SOD and aminoacid in Cordyceps
Active substances, has positive medical function for renal failure, cancer, emphysema and diabetes etc..
Cordyceps polysaccharide is a kind of highly branched galactomannan, and it can promote lymphocyte transformation,
Improve antibody content and the immunologic function of body, the energy that enhancing body self is anticancer of serum lgG
Power, improves liver detoxification function, plays liver protection effect.
Rhizoma Polygonati is the dry rhizome of liliaceous plant Polygonatum cyrtonema Hua, P. kingianum, polygonatum cirrhifolium Royle etc.,
Another name polygonatum sibiricum Redoute, Caput Gallus domesticus root.It has invigorating the spleen and replenishing QI, moistens the work such as cardiopulmonary, strong muscles and bones
With, clothes can be with life lengthening for a long time, for " integration of edible and medicinal herbs " plant.Polygonatum polysaccharide is that Rhizoma Polygonati water carries
The principle active component of thing, is also Rhizoma Polygonati primary bioactive components.Modern pharmacology confirms, yellow
Essence polysaccharide has blood sugar lowering, blood fat reducing, enhancing immunologic function, anti-ageing several functions of waiting for a long time.Greatly
Pharmacology and the clinical research of amount show, some polysaccharide compounds have immunoregulation effect, energy
Enough activate the immunocyte of body, improve its immunologic function.
Herba Cistanches can be divided mainly into phenethyl alcohol glycosides, iridoids, lignanoids, polysaccharide,
Ten several aminoacid, multiple alkaloid etc., rich in needed by human body trace element；There is raising exempt from
Effect of epidemic disease power, defying age, the liver protecting and cardiovascular and cerebrovascular vessel.The present invention designs water extraction meat desert
Rong, glycine betaine effective ingredient in main acquisition Herba Cistanches, to blood fat reducing, protection cardiovascular and cerebrovascular vessel tool
There is significant curative effect.
Content of Total Flavones in Hawthorn Leaves is higher, has the effect of blood fat reducing, blood pressure lowering.The present invention
Utilizing Folium Crataegi enzymolysis and extraction Fructus Crataegi flavone, extraction efficiency is high, good drug efficacy.
Semen Cassiae bitter in the mouth, sweet, salty, cold nature, enter liver, kidney, large intestine channel；Loosening bowel to relieve constipation,
Blood fat reducing improving eyesight, treatment constipation and hyperlipidemia, hypertension.Liver heat removing and eyesight improving, diuretic relieving constipation, have slow
Rush down effect, reducing blood pressure and blood fat.Containing phytosterol and anthraquinones in Semen Cassiae, have
The effect that suppression serum cholesterol raises and atheromatous plaque is formed, lipid-lowering effect shows
Write；Simultaneously evident in efficacy to hyperglycemia, hypertension, coronary heart disease and obesity.
Semen Ginkgo, it is sweet, bitter, puckery that Compendium of Material Medica records its property, and GUIXIN warp, lung meridian, function is held back
Lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving, can be used for treat cough and asthma due to lung deficiency, coronary heart diseases and angina pectoris,
Hyperlipidemia etc..Flavonoid substances in Folium Ginkgo, has function of promoting blood circulation to disperse blood clots, is mainly used in clinically
Arteriosclerosis and the coronary blood supply insufficiency of caused by hypertension, angina pectoris, myocardial infarction, brain
The treatment of the cardiovascular and cerebrovascular disease such as thromboembolism, cerebral vasospasm.
Radix Oenotherae erythrosepalae plant multiple chemical composition Han flavonoid, triterpenic acid etc., flavone in its middle period
Content is high, has the physiological functions such as antitumor, antioxidation, blood fat reducing, is that a kind of high-quality is natural
Health food resource.Alcohol heating reflux of the present invention extracts, and extraction efficiency is high.
Rhizoma Chuanxiong, gas giving off a strong fragrance, bitter in the mouth, pungent.Slightly numb feeling in the tongue, micro-Hui Tian, with Folium Nelumbinis, Pueraria lobota
The synergism such as root, Folium Psidii Guajavae, energy coronary artery dilator, increase coronary artery blood flow,
Improve the blood oxygen supply of cardiac muscle, and reduce myocardium oxygen consumption, surface activity of blood platelet can be reduced,
Suppression platelet aggregation, the formation of pre-preventing thrombosis；Energy blood pressure lowering, blood fat reducing, alleviate hypertension
The symptoms such as the headache that hyperlipidemia brings, dizzy, insomnia.
In Folium Nelumbinis in addition to containing conventional ingredients such as carbohydrate, lipid, protein, also richness
Containing multiple alkaloid, flavone compound, having antibacterial, blood fat reducing, fat-reducing, removing human body has
Do harm to the functions such as free radical, defying age, beauty treatment, the twin health care of relieving convulsion, treatment cardiovascular disease.This
Folium Nelumbinis powder is first broken to the powder that particle diameter is less by invention, then carries ultrasonic with after soak with ethanol
Take, it is thus achieved that extract in active constituent content high, and drug effect is notable.
Radix Puerariae, sweet, pungent, cool.Have an expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal it
Merit.Being usually used in exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, and the deficiency of YIN is quenched one's thirst,
Diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen.In the present invention, Radix Puerariae makes with compatibilities such as Rhizoma Chuanxiong, Semen Ginkgo and Rhizoma Polygonatis
With, there is reduction blood fat, the effect of blood pressure lowering.
Flos Chrysanthemi heat-clearing and toxic substances removing, uses with the compatibility such as Folium Nelumbinis, Rhizoma Polygonati, Semen Cassiae, Semen Ginkgo, has
Reduce blood pressure and the effect of blood fat.
Folium Psidii Guajavae bitter in the mouth；Puckery；Property flat, leaf contains cupreol, triterpenes.Again containing Cortex querci dentatae
Element, Fructus psidii guajavae immaturus tan flower glycoside, leucocyanidin, kind big pomegranate tan flower glycoside, piscidic acid, Herba Polygoni Avicularis
Glycoside (one say do not contain)；And containing volatile oil, evident in efficacy to hyperglycemia, hyperglycemia, high blood
Pressure and hyperlipidemia are to be mutually related, and three kinds of diseases the most simultaneously or sequentially occur, at this
Bright add Folium Psidii Guajavae, Radix Oenotherae erythrosepalae in the composition, use with other material combinations, alleviate three
The slight illness of high patient.
The present invention adds Radix Ginseng, Poria and Cordyceps effective component extracts, with Rhizoma Polygonati, meat desert
The compatibilities such as Rong, Folium Crataegi, Semen Ginkgo use, synergism, it is ensured that reduce blood fat, the treatment of blood pressure
On the basis of effect, improve the immunity of user, resistance, strengthening spleen and tonifying lung.The present invention adds
Folium Crataegi, Folium Nelumbinis extract, not only have the collaborative effect playing blood fat reducing, and, regulation
The taste of oral liquid, neutralizes the taste of other Chinese medicines, makes oral liquid mouthfeel more preferable.In the present invention
Rhizoma Chuanxiong, the addition of Radix Puerariae, can treat the complication that hyperlipidemia brings, and reduces cholesterol, carries
High therapeutic effect.
Compared with prior art, the most collaborative between each raw material in the present invention, with the use of, system
The oral liquid obtained is possible not only to reduce blood fat, blood glucose, and hyperlipidemia, hyperglycemia are alleviated in treatment simultaneously
The complication brought, improves therapeutic effect, improves immunity and the health level of user, controls
Treat instant effect, effective.
Detailed description of the invention
Embodiment 1
A kind of Chinese medicine composition, containing the raw material of following weight portion:
The preparation method of described ginseng extract is:
Being pulverized by the Radix Ginseng of purchase, the ethanol of the volume fraction 80% adding 7 times of weight adds
Circumfluence distillation 3 times, each 0.8-1.5h；Merging filtrate, drying under reduced pressure, prepare Radix Ginseng
Cream.
The preparation method of described Poria extracting solution is:
Poria is dried after pulverizing, cross 40 mesh sieves, add the water of 50 times amount, supersound extraction
30min；Filter, obtain filtrate, be concentrated into the 5g/ml of Poria weight.
The preparation method of described Cordyceps extracting solution is:
Cordyceps is pulverized, heating extraction 3 times, add the water of 5 times of weight at 65 DEG C for the first time
Extract 2h；Second time adds 5 times amount water, extracts 1h, add 4 times amount water for the 3rd time at 68 DEG C, 70 DEG C
Extracting 1.5h, filter, merging filtrate every time, the volume concentration of filtrate is to the 5 of Cordyceps weight
Times g/ml, obtains Cordyceps extracting solution.
The preparation method of described Rhizoma Polygonati extracting solution is:
Rhizoma Polygonati is pulverized, crosses 20 mesh sieves, after petroleum ether 90 DEG C backflow defat, heating extraction
3 times, the water adding 12 times of weight for the first time extracts 1.5h at 95 DEG C；Second time adds 10 times
Amount water extracts 1.5h at 90 DEG C, adds 10 times amount water for the 3rd time and extracts 1.5h at 85 DEG C, every time
Filter, merging filtrate, 4 times of g/ml of the volume concentration of filtrate to Cordyceps weight, obtain Huang
Essence extracting solution.
The preparation method of described Herba Cistanches extracting solution is:
Herba Cistanches is pulverized, heating extraction 3 times, add the water of 10 times of weight at 80-85 DEG C for the first time
Lower extraction 2h；Second time adds 9 times amount water and extracts 1h at 90 DEG C, adds 7 times amount water the 3rd time and exists
85 DEG C are extracted 1h, filter, merging filtrate every time, and the volume concentration of filtrate is to Herba Cistanches weight
5 times of g/ml, obtain Herba Cistanches extracting solution.
The preparation method of described Folium Crataegi extracting solution:
Weigh Folium Crataegi, add the distilled water of 15 times amount, the cellulase of 0.4% and 0.2%
Pectase, with hydrochloric acid tune pH value to 4,45 DEG C of vibrating at constant temperature for enzymolysis 100min, first to Fructus Crataegi
Leaf wall is destroyed, and is then warmed up at 85 DEG C extract 70min；After being cooled to room temperature,
Centrifugation, obtains supernatant；Residue Folium Crataegi residue washs 1 time with 80 DEG C of water, centrifugation,
Obtain cleaning mixture；2 supernatant are merged, is concentrated into 5 times of g/ml of Folium Crataegi weight,
To Folium Crataegi extracting solution.
The preparation method of described Semen Cassiae extracting solution is:
By Semen Cassiae 9 times of alcohol reflux 3 times, extract 1h every time；Residue volatilization is gone
After falling ethanol, the water extraction of addition 9 times of weight of residue 2 times, extracts 1h every time；After filtration,
It is 1.5g/mL that filtrate is concentrated into density, obtains Semen Cassiae extracting solution.
The preparation method of described Semen Ginkgo extrac is:
Dry Semen Ginkgo is pulverized 50 mesh sieves, with ethanol ultrasonic extraction 2 times, adds 10 for the first time
The ethanol of volume fraction 90% again, extracts 1-2h at 70 DEG C under 400W power；For the second time
At the ethanol of the volume fraction 75% of 12 times, at 70 DEG C, under 300W power, extract 1h, close
And filtrate, concentrating under reduced pressure, obtain Semen Ginkgo extrac.
The preparation method of described Radix Oenotherae erythrosepalae extract is:
Radix Oenotherae erythrosepalae pulverized 60 mesh sieves, heated with the ethanol of the volume fraction 80% of 30 times of weight
90 DEG C, reflux, extract, 2 times, each merging filtrate, after concentration, add 3 times of volumes
The ethanol remove impurity of volume fraction 95%, after being centrifuged, obtains filtrate, and filtrate is concentrated to give Radix Oenotherae erythrosepalae and extracts
Thing.
The preparation method of described Rhizoma Chuanxiong extracting solution is:
Rhizoma Chuanxiong is pulverized, heating extraction 2 times, adds 8 times amount water for the first time and extract 1h at 70 DEG C,
Second time adds 7 times amount water and extracts 0.5h at 90 DEG C, filters, merging filtrate every time, filtrate
Volume concentration, to 5 times of g/ml of Rhizoma Chuanxiong weight, obtains Rhizoma Chuanxiong extracting solution.
The preparation method of described Folium Nelumbinis extract is:
Folium Nelumbinis is dried, pulverizes, cross 120 mesh sieves, add the ethanol of volumetric concentration 60%, leaching
Bubble 12h, the EtOH Sonicate of the volumetric concentration 75% of 45 times of weight of the Lotus Leaf after immersion carries
Take 20min, filtrate concentrate drying, obtain Folium Nelumbinis extract.
The preparation method of described Radix Puerariae extracting solution is:
Radix Puerariae is pulverized, heating extraction 3 times, add the water of 25 times of weight at 95 DEG C for the first time
Extract 1.5h；Second time adds 15 times amount water, extracts 1h, add 26 times amount the 3rd time at 80 DEG C
Water, 80 DEG C are extracted 1h, filter, merging filtrate every time, and the volume concentration of filtrate is to Radix Puerariae weight
4 times of g/ml of amount, obtain Radix Puerariae extracting solution.
The preparation method of described chrysanthemum extract liquid is:
Weigh Flos Chrysanthemi appropriate, reflux, extract, twice, add 8 times amount water for the first time, soak ultrasonic
1h, extracts 1h, filters, and second time adds 10 times amount water, extracts 1h, filters, twice filtrate
Merging, the volume concentration of filtrate is 10 times of g/ml of Flos Chrysanthemi weight, obtains chrysanthemum extract liquid.
The preparation method of described Folium Psidii Guajavae extracting solution is:
Weigh Folium Psidii Guajavae appropriate, heating extraction twice, add 8 times amount water for the first time, heating is decocted
Boiling to 90 DEG C, extract 2h, filter, second time adds 7 times amount water, is heated to 90 DEG C, extracts
1h, filters, and twice filtrate merges, and the volume concentration of filtrate is 10 times of g/ml of Flos Chrysanthemi weight,
Obtain Folium Psidii Guajavae extracting solution.
The preparation method of a kind of Chinese medicine composition that the present invention provides, comprises the following steps:
(1) ginseng extract in formula, Poria extracting solution, Cordyceps extracting solution, Rhizoma Polygonati are extracted
Liquid, Herba Cistanches extracting solution, haw liquid extracting solution, Semen Cassiae extracting solution, Folium Ginkgo extract,
Radix Oenotherae erythrosepalae extracting solution, Rhizoma Chuanxiong extracting solution, Folium Nelumbinis extract, Radix Puerariae extracting solution, chrysanthemum extract liquid,
Folium Psidii Guajavae extracting solution and water are heated to 50 DEG C, stirring and evenly mixing；
(2) after cooling, adding the potassium sorbate of formula ratio, malic acid and CMC, stirring is mixed
Even, obtain Chinese medicine composition.
Embodiment 2
A kind of Chinese medicine composition, containing the raw material of following weight portion:
The preparation method of described ginseng extract is:
Being pulverized by the Radix Ginseng of purchase, the ethanol of the volume fraction 80% adding 7 times of weight adds
Circumfluence distillation 4 times, each 1h；Merging filtrate, drying under reduced pressure, prepare ginseng extract.
The preparation method of described Poria extracting solution is:
Poria is dried after pulverizing, cross 50 mesh sieves, add the water of 60 times amount, supersound extraction
30min；Filter, obtain filtrate, be concentrated into the 6g/ml of Poria weight.
The preparation method of described Cordyceps extracting solution is:
Cordyceps is pulverized, heating extraction 3 times, add the water of 7 times of weight at 68 DEG C for the first time
Extract 2h；Second time adds 5 times amount water, extracts 1h, add 4 times amount water the 3rd time at 70 DEG C,
70 DEG C are extracted 1.5h, filter, merging filtrate every time, and the volume concentration of filtrate is to Cordyceps weight
5 times of g/ml, obtain Cordyceps extracting solution.
The preparation method of described Rhizoma Polygonati extracting solution is:
Rhizoma Polygonati is pulverized, crosses 30 mesh sieves, after petroleum ether 90 DEG C backflow defat, heating extraction
3 times, the water adding 15 times of weight for the first time extracts 2h at 95 DEG C；Second time adds 15 times amount
Water extracts 1.5h at 90 DEG C, adds 10 times amount water for the 3rd time and extracts 1.5h at 90 DEG C, filters every time
Cross, merging filtrate, 5 times of g/ml of the volume concentration of filtrate to Cordyceps weight, obtain Rhizoma Polygonati
Extracting solution.
The preparation method of described Herba Cistanches extracting solution is:
Herba Cistanches is pulverized, heating extraction 3 times, add the water of 12 times of weight at 85 DEG C for the first time
Lower extraction 1.5h；Second time adds 9 times amount water and extracts 1.5h at 90 DEG C, adds 8 times amount the 3rd time
Water extracts 1h at 90 DEG C, filters, merging filtrate every time, and the volume concentration of filtrate is to Herba Cistanches
6 times of g/ml of weight, obtain Herba Cistanches extracting solution.
The preparation method of described Folium Crataegi extracting solution:
Weigh Folium Crataegi, add the distilled water of 20 times amount, the cellulase of 0.3% and 0.3%
Pectase, with hydrochloric acid tune pH value to 4,55 DEG C of vibrating at constant temperature for enzymolysis 150min, first to Fructus Crataegi
Leaf wall is destroyed, and is then warmed up at 90 DEG C extract 80min；After being cooled to room temperature,
Centrifugation, obtains supernatant；Residue Folium Crataegi residue washs 1 time with 90 DEG C of water, centrifugation,
Obtain cleaning mixture；2 supernatant are merged, is concentrated into 5 times of g/ml of Folium Crataegi weight,
To Folium Crataegi extracting solution.
The preparation method of described Semen Cassiae extracting solution is:
By Semen Cassiae 10 times of alcohol reflux 4 times, extract 2h every time；Residue volatilization is gone
After falling ethanol, the water extraction of addition 10 times of weight of residue 3 times, extracts 2h every time；After filtration,
It is 1.5g/mL that filtrate is concentrated into density, obtains Semen Cassiae extracting solution.
The preparation method of described Semen Ginkgo extrac is:
Dry Semen Ginkgo is pulverized 60 mesh sieves, with ethanol ultrasonic extraction 2 times, adds 20 for the first time
The ethanol of volume fraction 90% again, extracts 1.5h at 70 DEG C under 400W power；For the second time
At the ethanol of the volume fraction 75% of 15 times, at 70 DEG C, under 300W power, extract 2h, close
And filtrate, concentrating under reduced pressure, obtain Semen Ginkgo extrac.
The preparation method of described Radix Oenotherae erythrosepalae extract is:
Radix Oenotherae erythrosepalae pulverized 60 mesh sieves, heated with the ethanol of the volume fraction 80% of 30 times of weight
90 DEG C, reflux, extract, 2 times, each merging filtrate, after concentration, add 4 times of volumes
The ethanol remove impurity of volume fraction 95%, after being centrifuged, obtains filtrate, and filtrate is concentrated to give Radix Oenotherae erythrosepalae and extracts
Thing.
The preparation method of described Rhizoma Chuanxiong extracting solution is:
Rhizoma Chuanxiong is pulverized, heating extraction 2 times, add 10 times amount water 85 DEG C of extractions for the first time
1.5h, second time adds 7 times amount water and extracts 1h at 95 DEG C, filters, merging filtrate every time, filter
The volume concentration of liquid, to 6 times of g/ml of Rhizoma Chuanxiong weight, obtains Rhizoma Chuanxiong extracting solution.
The preparation method of described Folium Nelumbinis extract is:
Folium Nelumbinis is dried, pulverizes, cross 60 mesh sieves, add the ethanol of volumetric concentration 60%, leaching
Bubble 12h, the EtOH Sonicate of the volumetric concentration 75% of 45 times of weight of the Lotus Leaf after immersion carries
Take 25min, filtrate concentrate drying, obtain Folium Nelumbinis extract.
The preparation method of described Radix Puerariae extracting solution is:
Radix Puerariae is pulverized, heating extraction 3 times, add the water of 30 times of weight at 80-95 DEG C for the first time
Lower extraction 2h；Second time adds 20 times amount water, extracts 1.5h, add 28 times the 3rd time at 90 DEG C
Amount water, 90 DEG C are extracted 2h, filter, merging filtrate every time, and the volume concentration of filtrate is to Radix Puerariae
4 times of g/ml of weight, obtain Radix Puerariae extracting solution.
The preparation method of described chrysanthemum extract liquid is:
Weigh Flos Chrysanthemi appropriate, reflux, extract, twice, add 15 times amount water for the first time, soak ultrasonic
1h, extracts 1h, filters, and second time adds 10 times amount water, extracts 1h, filters, twice filtrate
Merging, the volume concentration of filtrate is 12 times of g/ml of Flos Chrysanthemi weight, obtains chrysanthemum extract liquid.
The preparation method of described Folium Psidii Guajavae extracting solution is:
Weigh Folium Psidii Guajavae appropriate, heating extraction twice, add 7 times amount water for the first time, heating is decocted
Boiling to 90 DEG C, extract 1h, filter, second time adds 6 times amount water, is heated to 85 DEG C, extracts
2h, filters, and twice filtrate merges, and the volume concentration of filtrate is 7 times of g/ml of Flos Chrysanthemi weight,
Obtain Folium Psidii Guajavae extracting solution.
The preparation method of a kind of Chinese medicine composition that the present invention provides, comprises the following steps:
(1) ginseng extract in formula, Poria extracting solution, Cordyceps extracting solution, Rhizoma Polygonati are extracted
Liquid, Herba Cistanches extracting solution, haw liquid extracting solution, Semen Cassiae extracting solution, Folium Ginkgo extract,
Radix Oenotherae erythrosepalae extracting solution, Rhizoma Chuanxiong extracting solution, Folium Nelumbinis extract, Radix Puerariae extracting solution, chrysanthemum extract liquid,
Folium Psidii Guajavae extracting solution and water are heated to 60 DEG C, stirring and evenly mixing；
(2) after cooling, adding the potassium sorbate of formula ratio, malic acid and CMC, stirring is mixed
Even, obtain Chinese medicine composition.
Embodiment 3
3.1 character
There are taste of Chinese medicine, viscous brown shape.
3.2pH value checks
PH value is at 7-7.2, direct-edible.
3.3 room temperature stability
It is placed in room temperature the most corrupt, the most spoiled, not stratified.
3.4 therapeutic effect are observed
Choose and 45-65 year suffer from the volunteer 100 of hyperlipidemia, be prepared by embodiment 1-2
Oral liquid liquid is taken to volunteer, and after continuous a period of time takes, patient removes examination in hospital again,
Represent that hyperlipidemia, hypertension and complication situation are obviously improved.
Claims (10)
1. a Chinese medicine composition, it is characterised in that described Chinese medicine composition contains following weight portion
Raw material:
Chinese medicine composition the most according to claim 1, it is characterised in that described ginseng extract
Preparation method is:
The Radix Ginseng of purchase is pulverized, adds the ethanol of the volume fraction 80% of 6-7 times of weight
Heating and refluxing extraction 3-4 time, each 0.8-1.5h；Merging filtrate, drying under reduced pressure, prepare
Ginseng extract；
The preparation method of described Poria extracting solution is:
Poria is dried after pulverizing, cross 40-60 mesh sieve, add the water of 50-60 times amount, ultrasonic
Extract 25-30min；Filter, obtain filtrate, be concentrated into the 3-6g/ml of Poria weight.
Chinese medicine composition the most according to claim 1, it is characterised in that described Cordyceps is extracted
The preparation method of liquid is:
Cordyceps is pulverized, heating extraction 3 times, add the water of 5-7 times of weight at 65-70 DEG C for the first time
Lower extraction 1.5-2h；Second time adds 4-6 times amount water, extracts 0.5-1.5h at 68-70 DEG C, the
Adding 3-5 times amount water for 3 times, 65-70 DEG C is extracted 0.5-1.5h, filters, merging filtrate every time,
The volume concentration of filtrate, to 3-6 times of g/ml of Cordyceps weight, obtains Cordyceps extracting solution.
Chinese medicine composition the most according to claim 1, it is characterised in that described Rhizoma Polygonati extracts
The preparation method of liquid is:
Rhizoma Polygonati is pulverized, crosses 20-40 mesh sieve, after petroleum ether 80-90 DEG C backflow defat, add
Heat is extracted 3 times, and the water adding 10-18 times of weight for the first time extracts 1.5-2h at 90-95 DEG C；
Second time adds 10-15 times amount water and extracts 0.5-1.5h at 85-90 DEG C, adds 8-12 times the 3rd time
Amount water extracts 0.5-1.5h at 85-90 DEG C, filters, merging filtrate every time, and the volume of filtrate is dense
It is reduced to 3-6 times of g/ml of Cordyceps weight, obtains Rhizoma Polygonati extracting solution.
Chinese medicine composition the most according to claim 1, it is characterised in that described Herba Cistanches carries
The preparation method taking liquid is:
Being pulverized by Herba Cistanches, heating extraction 3 times, the water adding 10-12 times of weight for the first time exists
1.5-2h is extracted at 80-85 DEG C；Second time adds 8-10 times amount water 85-90 DEG C of extraction
0.5-1.5h, adds 6-8 times amount water for the 3rd time and extracts 0.5-1h at 85-90 DEG C, filter every time,
Merging filtrate, 4-6 times of g/ml of the volume concentration of filtrate to Herba Cistanches weight, obtain meat desert
Rong's extracting solution.
Chinese medicine composition the most according to claim 1, it is characterised in that described Folium Crataegi carries
Take the preparation method of liquid:
Weigh Folium Crataegi, add the distilled water of 15-20 times amount, the cellulase of 0.2-0.4% and
The pectase of 0.2-0.4%, with hydrochloric acid tune pH value to 4-5,45-55 DEG C of vibrating at constant temperature for enzymolysis
100-150min, first destroys Folium Crataegi cell wall, extracts at being then warmed up to 85-90 DEG C
60-90min；After being cooled to room temperature, centrifugation, obtain supernatant；Residue Folium Crataegi residue is used
80-90 DEG C of water washs 1 time, and centrifugation obtains cleaning mixture；2 supernatant are merged, concentrates
To 4-6 times of g/ml of Folium Crataegi weight, obtain Folium Crataegi extracting solution；
The preparation method of described Semen Cassiae extracting solution is:
By Semen Cassiae 8-10 times of alcohol reflux 3-4 time, extract 1-2h every time；Residue
After ethanol is removed in volatilization, the water extraction of addition 8-10 times of weight of residue 2-3 time, extracts every time
1-2h；After filtration, it is 1-1.5g/mL that filtrate is concentrated into density, obtains Semen Cassiae extracting solution.
Chinese medicine composition the most according to claim 1, it is characterised in that described Semen Ginkgo is extracted
The preparation method of thing is:
Dry Semen Ginkgo was pulverized 40-60 mesh sieve, with ethanol ultrasonic extraction 2 times, added for the first time
The ethanol of the volume fraction 90% of 10-20 times, extracts 1-2h at 70 DEG C under 400W power；
Second time is at the ethanol of the volume fraction 75% of 10-15 times, at 60-70 DEG C under 300W power
Extract 1-2h, merging filtrate, alkali liquor concentration, obtain Semen Ginkgo extrac；
The preparation method of described Radix Oenotherae erythrosepalae extract is:
Radix Oenotherae erythrosepalae pulverized 40-60 mesh sieve, by the second of the volume fraction 80% of 25-30 times of weight
Alcohol heats 80-90 DEG C, reflux, extract, 2 times, and each merging filtrate, after concentration, adds 3-4
The ethanol remove impurity of the volume fraction 95% of times volume, centrifugal after, obtain filtrate, filtrate is concentrated to give
Radix Oenotherae erythrosepalae extract.
Chinese medicine composition the most according to claim 1, it is characterised in that described Rhizoma Chuanxiong extracts
The preparation method of liquid is:
Rhizoma Chuanxiong is pulverized, heating extraction 2 times, add 8-11 times amount water 70-90 DEG C of extraction for the first time
0.5-2h, second time adds 6-8 times amount water and extracts 0.5-1h at 85-95 DEG C, filter every time, closes
And filtrate, 4-6 times of g/ml of the volume concentration of filtrate to Rhizoma Chuanxiong weight, obtain Rhizoma Chuanxiong and extract
Liquid；
The preparation method of described Folium Nelumbinis extract is:
Folium Nelumbinis is dried, pulverizes, cross 100-160 mesh sieve, add the ethanol of volumetric concentration 60%,
Soak 10-12h, the second of the volumetric concentration 75% of 40-45 times of weight of the Lotus Leaf after immersion
Alcohol supersound extraction 20-25min, filtrate concentrate drying, obtain Folium Nelumbinis extract.
Chinese medicine composition the most according to claim 1, it is characterised in that described Radix Puerariae extracts
The preparation method of liquid is:
Radix Puerariae is pulverized, heating extraction 3 times, add the water of 25-30 times of weight at 80-95 DEG C for the first time
Lower extraction 1.5-2h；Second time adds 15-25 times amount water, extracts 0.5-1.5h at 80-90 DEG C,
Adding 25-28 times amount water for 3rd time, 80-90 DEG C is extracted 0.5-2h, filters, merging filtrate every time,
The volume concentration of filtrate, to 3-6 times of g/ml of Radix Puerariae weight, obtains Radix Puerariae extracting solution；
The preparation method of described chrysanthemum extract liquid is:
Weigh Flos Chrysanthemi appropriate, reflux, extract, twice, add 6-15 times amount water for the first time, soak super
Sound 0.5-1h, extracts 0.5-2h, filters, and second time adds 6-15 times amount water, extracts 0.5-2h,
Filtering, twice filtrate merges, and the volume concentration of filtrate is 5-15 times of g/ml of Flos Chrysanthemi weight,
Obtain chrysanthemum extract liquid；
The preparation method of described Folium Psidii Guajavae extracting solution is:
Weigh Folium Psidii Guajavae appropriate, heating extraction twice, add 5-10 times amount water for the first time, add
Heat decocts to 80-90 DEG C, extracts 0.5-2h, filters, and second time adds 6-8 times amount water, heating
To 85-90 DEG C, extracting 0.5-2h, filter, twice filtrate merges, and the volume concentration of filtrate is
5-15 times of g/ml of Flos Chrysanthemi weight, obtains Folium Psidii Guajavae extracting solution.
10. a preparation method for the Chinese medicine composition described in any one of claim 1-9, including with
Lower step:
(1) ginseng extract in formula, Poria extracting solution, Cordyceps extracting solution, Rhizoma Polygonati are extracted
Liquid, Herba Cistanches extracting solution, haw liquid extracting solution, Semen Cassiae extracting solution, Folium Ginkgo extract,
Radix Oenotherae erythrosepalae extracting solution, Rhizoma Chuanxiong extracting solution, Folium Nelumbinis extract, Radix Puerariae extracting solution, chrysanthemum extract liquid,
Folium Psidii Guajavae extracting solution and water are heated to 50-70 DEG C, stirring and evenly mixing；
(2) after cooling, adding the potassium sorbate of formula ratio, malic acid and CMC, stirring is mixed
Even, obtain Chinese medicine composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610563081.5A CN105998661A (en) | 2016-07-15 | 2016-07-15 | Traditional Chinese medicine composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610563081.5A CN105998661A (en) | 2016-07-15 | 2016-07-15 | Traditional Chinese medicine composition and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105998661A true CN105998661A (en) | 2016-10-12 |
Family
ID=57118431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610563081.5A Withdrawn CN105998661A (en) | 2016-07-15 | 2016-07-15 | Traditional Chinese medicine composition and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105998661A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106720358A (en) * | 2016-11-28 | 2017-05-31 | 山东坤泰生物科技有限公司 | A kind of blending type modulation breast and preparation method thereof |
| CN107050349A (en) * | 2017-05-04 | 2017-08-18 | 南京苏新智慧社区服务有限公司 | A kind of cream taste of toxin expelling promoting blood circulation and its preparation method and application |
| CN108969658A (en) * | 2018-08-10 | 2018-12-11 | 梅峻 | A kind of preparation method of hundred hay-scenteds mist |
| CN111603500A (en) * | 2020-06-30 | 2020-09-01 | 河南中大恒源生物科技股份有限公司 | Semen cassiae extract and process technology for comprehensively developing and utilizing semen cassiae |
-
2016
- 2016-07-15 CN CN201610563081.5A patent/CN105998661A/en not_active Withdrawn
Non-Patent Citations (2)
| Title |
|---|
| 陈君慧: "《中华酒典》", 31 January 2013, 黑龙江科学技术出版社 * |
| 韦桂宁: "《图解中医六大名著》", 31 May 2014, 中医古籍出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106720358A (en) * | 2016-11-28 | 2017-05-31 | 山东坤泰生物科技有限公司 | A kind of blending type modulation breast and preparation method thereof |
| CN107050349A (en) * | 2017-05-04 | 2017-08-18 | 南京苏新智慧社区服务有限公司 | A kind of cream taste of toxin expelling promoting blood circulation and its preparation method and application |
| CN108969658A (en) * | 2018-08-10 | 2018-12-11 | 梅峻 | A kind of preparation method of hundred hay-scenteds mist |
| CN111603500A (en) * | 2020-06-30 | 2020-09-01 | 河南中大恒源生物科技股份有限公司 | Semen cassiae extract and process technology for comprehensively developing and utilizing semen cassiae |
| CN111603500B (en) * | 2020-06-30 | 2022-03-04 | 河南中大恒源生物科技股份有限公司 | Semen cassiae extract and process technology for comprehensively developing and utilizing semen cassiae |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101890130B (en) | Health wine raw materials and health wine | |
| CN1170588A (en) | Pure natural plant human life energy nutritive substrate | |
| CN101804165B (en) | Preparation for clearing nephrotoxicity, strengthening internal organs, enhancing physique and preventing aging and preparation method thereof | |
| CN102172385B (en) | A kind of Chinese medicine preparation with enhancing immunity, blood sugar lowering and effect for reducing blood fat | |
| CN1569207A (en) | Prescription for blackening hair and prolonging life and its preparation | |
| CN101485830A (en) | Pure Chinese medicine anti-aging health-care capsule | |
| CN105998661A (en) | Traditional Chinese medicine composition and preparation method thereof | |
| CN103734835B (en) | A kind of yam active functional drink and preparation method thereof | |
| CN106138869A (en) | A kind for the treatment of four high Chinese medicine compositions and preparation method thereof | |
| CN106937741A (en) | A kind of degreasing linseed meal cancer-resisting health slimming method and preparation method thereof | |
| CN103301413A (en) | Traditional Chinese medicine composition for treating hyperlipemia and hyperglycemia | |
| CN104905267A (en) | Semen cassiae health oral liquid capable of decreasing blood lipid and preparation method thereof | |
| CN103960429A (en) | Health food with effect of healthily reducing weight of user | |
| CN103749818A (en) | Rhizoma polygonati healthcare tea with hypoglycemic and hypolipidemic effects and preparation method thereof | |
| CN101152359A (en) | Health care medicinal liquor and preparation method thereof | |
| CN101700341A (en) | Biological composition for nourishing kidney and protecting liver and preparation method for oral liquid thereof | |
| CN101987167A (en) | Medicine with cathartic function | |
| CN102961611A (en) | Health-care medicinal liquor and preparation method thereof | |
| CN106036296A (en) | Health-care beverage capable of reducing blood pressure and making method of health-care beverage | |
| CN1685972A (en) | Antisenility health care food | |
| CN103725587A (en) | Sealwort and hawthorn vinegar and production method thereof | |
| CN1444953A (en) | Health protection wine for improvement of inferior health | |
| CN106109911A (en) | One seed ginseng Siberian cocklebur grass oral liquid and preparation method thereof | |
| CN106215094A (en) | A kind of relieving alcoholism and protecting the liver health product and preparation method thereof | |
| CN1101199C (en) | Chinese-medicinal capsule for treating hyperlipomia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161012 |