CN105998644A - Pharmaceutical composition for treating tinea pedis and preparation method thereof - Google Patents
Pharmaceutical composition for treating tinea pedis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treating tinea pedis and a preparation method thereof. The pharmaceutical composition is prepared from the following raw materials: grenateleaf heteropappus herb, pennycress, Cydonia oblonga, Adenophora trachelioides, Japanese saussurea herb, rhynchosia volubilis, nakedflower beautyberry branchlet and leaf, honeysuckle, Vitis bryoniifolia Bunge, apricot kernel, gambleana spicebush root and leaf, malabarnut branchlet and leaf, nephelium lappaceum, patience dock root, Syzygium sanarangense, rhizome of Largeleaf Japanese Ginseng, duckweed, ashycoloured ironweed herb, Sanguisorba officinalis, polygonatum, Gorgon fruit, cape jasmine, common embelia root branchlet and leaf, Corydalis gigantea, henry sarmentose fig receptacle, cladonia fallax lichen and robust leontice rhizome and root. The invention has the beneficial effects that the pharmaceutical composition has the efficacies of clearing heat, detoxifying, relieving swelling and pain, dispelling wind and dampness and relieving itching; and the pharmaceutical composition has the advantages of quick and high effectiveness, high efficiency, definite therapeutic effect, short treatment course, no toxic or side effect, and low price.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine pharmacy, particularly to a kind of pharmaceutical composition treating tinea pedis and preparation side thereof
Method.
Background technology
Tinea pedis, is that fungal infection causes, and its skin lesion the most unilateral (i.e. single foot), after a couple of days, several weeks or several months
Just infect another foot.Water scar mainly appears on toe abdomen and toe side, is most commonly between three or four toes, and vola also may occur in which.For deeply existing
Property phlysis, can gradually be fused into big scar.The skin lesion of tinea pedis has a feature, i.e. clear border, can gradually outward expansion, but
Will never be diffusivity, obscure boundary Chu.Because of PD or scratch, may occur in which erosion, sepage, even antibacterial infects, go out
Existing pustule etc..
Tinea pedis has another name called tinea pedis, is the dermatosis caused in foot by pathogenic skin filamentous fungi, usually through foot basin,
Bath towel, footgear and other route infection such as medicated clothing or close contact, and be the main source of other body parts tinea.Tinea pedis
Treatment is not in time, it is also possible to climing and other positions, as caused the tinea manuum and tinea unguium etc., is sometimes scratched because itching, secondary bacterial sense
Dye, can cause serious complication.Tinea pedis has and is divided into erosive type, vesicle, hyperkeratotic pattern, pimple squama type etc..China cures
Think that primary disease is dysfunction of the spleen in transportation, retention of water-damp in the body, and endogenous dampness accumulates heat-transformation for a long time, damp invasion of lower energizer, infects caused by exopathogen.According to primary disease
Etiology and pathogenesis, should be with dispeiling pathogenic wind and removing dampness killing parasites for relieving itching as therapeutic rules.Primary disease is closely related with ailment said due to cold or exposure." surgery section great achievement is all itches "
In have opinion ": wind is contained and is then itched, and covers as wind person, and the woods of fire is also.All wind heat visitor is in skin, and had an itch foxtail millet person, controls suitable dispelling wind." in south
Region is most commonly seen with " wind heat folder is wet " again.Clinical diagnosis: tinea pedis is by fungus-caused common skin diseases.Its symptom is toe
Between to play vesicle, decortication or skin whitening wet soft, it is possible to rotten to the corn or pachyderma, coarse, cracking occur, and can spread to sole and
Foot head edge, play is itched, it is necessary to till scratching.Therefore often companion local suppuration, red and swollen, pain, inguinal lymphadenopathy, even formed
The secondary infection such as shank erysipelas and cellulitis.Owing to being held by hand place of itching, often infect to hands and the tinea manuum (fungal infection of hand and foot) occurs.Very
Bacterium is referring to growth in (toe) first, then become tinea unguium (tinea unguium).Fungus likes the environment of damp warm, and summer, sky overabundant heat antiperspirant, wore glue
Footwear, nylon sock person provide hotbed for fungus especially;Winter, the many improvements of the state of an illness, showed as skin cracks.Erosive type tinea pedis shows
Macerate for local horny layer of epidermis and turn white.Constantly rub during owing to walking about exfoliation, exposes cerise erosion face；Severe patient toe
Between seam, toe abdomen all can accumulate with vola intersection skin, acute pruritus, be mainly in 3.4.5 toe seam between.It is common in hyperhidrosis person.
Modern medicine is thought, tinea pedis is typically due to (one) pathogenic factor trichophyton or cotton-shaped that the following cause of disease causes
Epidermophyton, can form arthrospore in scurf, energy long term survival in natural environment, and is infectious.(2) morbidity machine
Tinea pedis sickness rate height processed is also relevant with foot anatomical features, enriches including foot sole of the foot portion sweat gland, and perspiration is many, without sebaceous gland, skin table
Face meta-alkalescence, beneficially fungus growth, and thicker the growth for fungus of horny layer provides abundant nutrition, additionally, red hair tinea
Bacterium or acrothesium floccosum, can form arthrospore in scurf, energy long term survival in natural environment, and is infectious, and makes
Foot infection chance increases.
Take have erosion, sepage person between (1) toe in treatment, it is not possible to the medicine that external zest is strong more, the most first make wound surface
Convergence is dried medication again.Can (taking its powder warm water and being dissolved to water be baby pink, color with 1: 8000 potassium permanganate solution
The deepest, concentration is the highest can corrode skin on the contrary) soak, then external-use oil preparation or powder, after xerosis cutis, use hydrochloric acid instead
The cream such as terbinafine or ointment.(2) if Keratoderma thickens seriously, antifungal drug is difficult to osmotic absorption, can first use
10% unguentum acidi salicylici or split clean, whitfield ointment etc. and make cutin softening, then use antifungal agent.The obvious person of chapped skin, can
With each warm water soaking, make cutin softening, then use antifungal agent.The obvious person of chapped skin, can local after warm water soaking every time
It is coated with ointment, then uses plastic sheeting package, twine outward binder, remove after 24～48 hours, use antifungal agent the most again.(3) foot
Play phlysis, non-ulceration person, first can soak by 3% boric acid solution, then select the antifungal cream such as Bifonazole cream.(4)
Tinea pedis merge antibacterial infect, in principle should first local bacterial-infection resisting.Can be molten with furacilin solution or 1: 2000 berberine
Liquid soak.Another kind of effective method is to soak with Chinese herbs decoction.As with Herba Portulacae 30 grams, Radix Sangusorbae 30 grams, 10 grams of Alumen, water
Soak or soak after Jianing, every day 20～30 minutes, after infection control, then be coated with antifungal agent beyond the region of objective existence.Severe infections person, permissible
Oral antibiotic, such as cefalexin capsule, midecamycin, erythromycin etc..(5) whole body therapeutic is for obstinate tinea pedis, is not having
In the case of contraindication, oral medicine can be given.Such as Lamisil (Terbinafine), itraconazole (itraconazole), Fluconazole (fluorine
Health azoles) etc..These oral drugs are effective, but it should be noted that its side reaction that may bring, hepatic disfunction person avoids use.
Noting topical health at ordinary times, soap washing preferably commonly used by socks, shines, should not wear rubber overshoes or plastic bottom footwear, not with public
Slippers or foot cloth, treatment acrohyperhidrosis and pompholyx, footwear the most often shines or with cotton balls leaching formaldehyde (formalin) put in footwear sealing 24～
48h, has fungus killing effect, after secondary bacterial infection person is except local treatment, can drink and use antibacterial.
Summary of the invention
The invention provides a kind of pharmaceutical composition treating tinea pedis and preparation method thereof；Having heat-clearing and toxic substances removing, detumescence is only
Bitterly, expelling wind and removing dampness, antipruritic effect；Have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, valency
The advantages such as lattice are low.
For solving above-mentioned technical problem, the present invention provides a kind of pharmaceutical composition treating tinea pedis, wherein, described medicine group
Compound is made up of following raw medicinal material: Herba heteropappi crenatifolii, Xi, shepherd's purse, Herba Saussuseae Japonicae, Herba rhynchosiae volubilis, Folium et Ramulus Callicarpae nudiflorae, Flos Lonicerae,
Semen Armeniacae Amarum, Radix Rumicis Patientiae, Fructus nephelii topengii, Eugenia javanica Lam root, Rhizoma panacis majoris, Herba Spirodelae, Herba Vernoniae Cinereae, Radix Sanguisorbae, Rhizoma Polygonati Odorati, Semen Euryales, Fructus Gardeniae, Radix embeliae laetae and red hair
Seven.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: Herba heteropappi crenatifolii 8-16 weight portion, Xi 12-22
Weight portion, 9-18 weight portion, shepherd's purse 13-31 weight portion, Herba Saussuseae Japonicae 15-25 weight portion, Herba rhynchosiae volubilis 14-36 weight portion, catch up with wind
Bavin 15-25 weight portion, Flos Lonicerae 10-30 weight portion, 12-32 weight portion, Semen Armeniacae Amarum 2-4 weight portion, Radix Rumicis Patientiae 12-34 weight
Part, Fructus nephelii topengii 9-15 weight portion, Eugenia javanica Lam root 11-23 weight portion, Rhizoma panacis majoris 15-28 weight portion, Herba Spirodelae 15-35 weight portion, Herba Vernoniae Cinereae
14-28 weight portion, Radix Sanguisorbae 10-20 weight portion, Rhizoma Polygonati Odorati 16-32 weight portion, Semen Euryales 9-18 weight portion, Fructus Gardeniae 15-45 weight portion, acid
Rattan wood 12-24 weight portion and Radix Caulophylli 9-14 weight portion.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: Herba heteropappi crenatifolii 9-15 weight portion, Xi 14-20
Weight portion, 10-18 weight portion, shepherd's purse 14-30 weight portion, Herba Saussuseae Japonicae 15-25 weight portion, Herba rhynchosiae volubilis 14-35 weight portion, catch up with wind
Bavin 15-25 weight portion, Flos Lonicerae 10-30 weight portion, 14-32 weight portion, Semen Armeniacae Amarum 2-3 weight portion, Radix Rumicis Patientiae 14-34 weight
Part, Fructus nephelii topengii 9-15 weight portion, Eugenia javanica Lam root 12-22 weight portion, Rhizoma panacis majoris 15-28 weight portion, Herba Spirodelae 15-35 weight portion, Herba Vernoniae Cinereae
14-26 weight portion, Radix Sanguisorbae 10-20 weight portion, Rhizoma Polygonati Odorati 18-30 weight portion, Semen Euryales 10-18 weight portion, Fructus Gardeniae 15-45 weight portion,
Radix embeliae laetae 12-23 weight portion and Radix Caulophylli 10-14 weight portion.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: Herba heteropappi crenatifolii 12 weight portion, Xi 16 weight
Part, 10 weight portions, shepherd's purse 25 weight portion, Herba Saussuseae Japonicae 17 weight portion, Herba rhynchosiae volubilis 33 weight portion, Folium et Ramulus Callicarpae nudiflorae 20 weight portion, gold silver
Spend 15 weight portions, 26 weight portions, Semen Armeniacae Amarum 2 weight portion, Radix Rumicis Patientiae 33 weight portion, Fructus nephelii topengii 13 weight portion, Eugenia javanica Lam root 21 weight
Part, Rhizoma panacis majoris 25 weight portion, Herba Spirodelae 32 weight portion, Herba Vernoniae Cinereae 24 weight portion, Radix Sanguisorbae 15 weight portion, Rhizoma Polygonati Odorati 30 weight portion, Semen Euryales
15 weight portions, Fructus Gardeniae 42 weight portion, Radix embeliae laetae 22 weight portion and Radix Caulophylli 13 weight portion.
The raw medicinal material of described pharmaceutical composition also includes: Folium Malloti Apeltae, Ramulus Et Folium Adhatodae Vasicae, Corydalis gigantea et Meer., Receptaculum fici Henryi and Cladonia fallax Abbayes.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: Herba heteropappi crenatifolii 9-15 weight portion, Xi 14-20
Weight portion, 10-18 weight portion, shepherd's purse 14-30 weight portion, Herba Saussuseae Japonicae 15-25 weight portion, Herba rhynchosiae volubilis 14-35 weight portion, catch up with wind
Bavin 15-25 weight portion, Flos Lonicerae 10-30 weight portion, 14-32 weight portion, Semen Armeniacae Amarum 2-3 weight portion, Radix Rumicis Patientiae 14-34 weight
Part, Fructus nephelii topengii 9-15 weight portion, Eugenia javanica Lam root 12-22 weight portion, Rhizoma panacis majoris 15-28 weight portion, Herba Spirodelae 15-35 weight portion, Herba Vernoniae Cinereae
14-26 weight portion, Radix Sanguisorbae 10-20 weight portion, Rhizoma Polygonati Odorati 18-30 weight portion, Semen Euryales 10-18 weight portion, Fructus Gardeniae 15-45 weight portion,
Radix embeliae laetae 12-23 weight portion, Radix Caulophylli 10-14 weight portion, Folium Malloti Apeltae 10-14 weight portion, Ramulus Et Folium Adhatodae Vasicae 10-14 weight portion, huge purple
Violet 2-4 weight portion, Receptaculum fici Henryi 14-36 weight portion and Cladonia fallax Abbayes 10-20 weight portion.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: Herba heteropappi crenatifolii 12 weight portion, Xi 16 weight
Part, 10 weight portions, shepherd's purse 25 weight portion, Herba Saussuseae Japonicae 17 weight portion, Herba rhynchosiae volubilis 33 weight portion, Folium et Ramulus Callicarpae nudiflorae 20 weight portion, gold silver
Spend 15 weight portions, 26 weight portions, Semen Armeniacae Amarum 2 weight portion, Radix Rumicis Patientiae 33 weight portion, Fructus nephelii topengii 13 weight portion, Eugenia javanica Lam root 21 weight
Part, Rhizoma panacis majoris 25 weight portion, Herba Spirodelae 32 weight portion, Herba Vernoniae Cinereae 24 weight portion, Radix Sanguisorbae 15 weight portion, Rhizoma Polygonati Odorati 30 weight portion, Semen Euryales
15 weight portions, Fructus Gardeniae 42 weight portion, Radix embeliae laetae 22 weight portion, Radix Caulophylli 13 weight portion, Folium Malloti Apeltae 12 weight portion, Ramulus Et Folium Adhatodae Vasicae 10 weight
Amount part, Corydalis gigantea et Meer. 3 weight portion, Receptaculum fici Henryi 35 weight portion and Cladonia fallax Abbayes 20 weight portion.
When the dosage form of described pharmaceutical composition is granule, its preparation method comprises the following steps:
The first step, is mixed described raw medicinal material in described ratio, add relative to the determining alcohol of mixture 4～8 times be 85%～
The ethanol of 95%, is heated to boiling reflux 3～5 hours, filters, use percolation with per minute 1～2ml speed slowly percolation,
Collect percolate, when being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa relative density be 1.04～
The mastic of 1.10, is spray-dried, the inlet temperature 160 of spray dryer～175 DEG C, leaving air temp 80～85 DEG C, pulverizes subsequently
Become powder, make dried cream powder；
Second step, adds relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times and 0.1～0.2 times in the dried cream powder obtained
Dextrin, make granule, in 40～50 DEG C be dried, it is thus achieved that granule.
When the dosage form of described pharmaceutical composition is injectable powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, puts into and is ground into 0.1～10 μm volume average particle in super micron mill
The mixed powder that the micron particles in footpath and particle diameter form less than the nano-scale particle of 0.1 μm volume average particle size, described mixing
The powder rate that obtains of powder is at least 95%；
Second step, adds the quality 3 relative to described mixed powder～the determining alcohol of 5 times in the mixed powder that the first step obtains
Being the ethanol of 85%～95%, stirring and dissolving obtains ethanol solution, and ethanol solution stands under conditions of 5 DEG C～10 DEG C 24～36
Hour, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, be concentrated and dried, and put at this
Super micron mill is pulverized 40～60 minutes, it is thus achieved that the micron particles of 0.1～10 μm volume average particle size and particle diameter are less than 0.1
The mixed powder of the nano-scale particle composition of μm volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection,
Stirring makes it dissolve, and injects water to 1000ml further, adds 1g～1.5g needle-use activated carbon, is sufficiently stirred for 30～50
Minute；Decarbonization filtering；With 0.22～0.24 μm filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding.
When the dosage form of described pharmaceutical composition is ointment, and preparation method comprises the following steps:
The first step, according to ratio of weight and number weigh Xi, shepherd's purse, Herba Saussuseae Japonicae and Herba rhynchosiae volubilis, add above-mentioned raw materials medicine medical material total
The water of weight 5-10 times amount, soaks 1-2 hour, extracts the volatile oil of 2-5 hour, and extracting method is steam distillation or super faces
Boundary's extraction extracts, and collects volatile oil, and medicinal liquid filters, and medicinal residues are standby；
Second step, weighs surplus stock medical material according to ratio of weight and number, mixes with the medicinal residues in step (1), total after putting into mixing
In the ethanol of the 95% of weight 6-8 times amount, soak 2 hours；After immersion, at 70～80 DEG C, heat is extracted, and obtains extracting solution 1, and medicinal residues are standby
With;
3rd step, adds in the ethanol of 85% of medicinal residues gross weight 5～8 times amount, heating and refluxing extraction 2 in the medicinal residues of step (2)
Secondary, each 1～2 hour, 2 extracting solution are merged and stands, obtain extracting solution 2, medicinal residues are standby；
4th step, will add the water of 5～8 times amount of medicinal residues weight in the medicinal residues of step (3), heating and refluxing extraction 2 times, each 2 little
Time, 2 extracting solution are merged and stands, obtain extracting solution 3；
5th step, merges extracting solution 1, extracting solution 2 and extracting solution 3, and when concentrating under reduced pressure obtains 80 DEG C, relative density is the filter of 1.35
Liquid, reclaims ethanol, and by gained filtrate adjustment proportion to when 80 DEG C 1.06, reduce pressure to obtain extractum, glycerol adding furnishing ointment.
Beneficial effects of the present invention: the present invention has heat-clearing and toxic substances removing, reducing swelling and alleviating pain, expelling wind and removing dampness, antipruritic effect；Have
Rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.
Detailed description of the invention
The present invention provides a kind of pharmaceutical composition treating tinea pedis and preparation method thereof, wherein, including following raw medicinal material:
Herba heteropappi crenatifolii, Xi, shepherd's purse, Herba Saussuseae Japonicae, Herba rhynchosiae volubilis, Folium et Ramulus Callicarpae nudiflorae, Flos Lonicerae, Semen Armeniacae Amarum, Folium Malloti Apeltae, Ramulus Et Folium Adhatodae Vasicae, Fructus nephelii topengii,
Radix Rumicis Patientiae, Eugenia javanica Lam root, Rhizoma panacis majoris, Herba Spirodelae, Herba Vernoniae Cinereae, Radix Sanguisorbae, Rhizoma Polygonati Odorati, Semen Euryales, Fructus Gardeniae, Radix embeliae laetae, Corydalis gigantea et Meer., Receptaculum fici Henryi, gold
Brush handle and Radix Caulophylli.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Semen Euryales: another name: Gorgon fruit, Caput Gallus domesticus.Source: this product is being dried of nymphaeaceae plant Gorgon euryale Euryale ferox Salisb.
Mature seed kernel.Time of the year when autumn changes into winter gathers mature fruit, removes peel, takes out seed, cleans, then removes duricrust (episperm), dries.
Nature and flavor: sweet, puckery are flat.Gui Jing: return spleen, kidney channel.Cure mainly: supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, damp eliminating leukorrhagia stopping.For emission, lose
Urinate frequently, insufficiency of the spleen chronic diarrhea, nebulousurine, leukorrhagia.
: another name: Radix vitis romanetii, Vitis Amurensis.Source: Vitaceae Vitis plant Vitis adstricta
Hance [V. thunbergii Sieb. et Zncc. var. adstricta (Hance) Gagnep.], with Herb, or
Root, stem, leaf and fruit are used as medicine.The whole year can adopt, and root, stem, leaf is dried respectively or using fresh herb, and fruit is taken time ripe, dries.Nature and flavor: acid,
Sweet, puckery, flat.Cure mainly: heat-clearing and toxic substances removing, expelling wind and removing dampness.For hepatitis, appendicitis, mastitis, lung abscess, multiple abscess, rheumatism
Property arthritis；Sore swollen toxin, otitis media, snake bite and insect sting are controlled in external.
: another name: wooden ploughs.Source: Rosaceae platymiscium Cydonia oblonga Mill., with fruit
It is used as medicine.Gather after maturation, dry in the shade.Nature and flavor: sweet, sour, temperature.Cure mainly: damp eliminating expelling summer-heat, relaxing muscles and tendons and activating QI and blood in the collateral.For Sunstroke, vomiting, suffer from diarrhoea,
Dyspepsia, arthralgia, sural spasm.
Herba Saussuseae Japonicae: source: " decoction pieces is newly joined ".Another name: Sambucus chinensis (" pharmacognosy "), Herba Scindapsi Officinalis (" medicine investigation is planted in Guizhou "),
Octahedral wind, Herba Caricis Phacotae (" Guizhou medical herbs ").Source: for the herb of feverfew hieracioides.Extract herb about July, dry.
Nature and flavor: arduous are flat.1. " decoction pieces is newly joined ": " bitter in the mouth, property is put down." 2. " medicine investigation is planted in Guizhou ": " is arduous, cold." cure mainly: work of dispeling the wind
Blood.Dispelling the wind and dampness pathogens arthralgia pain, traumatic injury, leprosy.1. " decoction pieces is newly joined ": " promoting blood circulation by removing wind dissipates numbness pain relieving." 2. " Guizhou is planted medicine and is adjusted
Look into ": " relaxing muscles and tendons and activating QI and blood in the collateral, antalgic rheumatism-treating."
Herba rhynchosiae volubilis: another name: mouse eye, Herba desmodii multifloi [Hunan], expectorant cut bean.Source: pulse family Herba rhynchosiae volubilis platymiscium Herba rhynchosiae volubilis Rhynchosia
Volubilis Lour., with root and all herbal medicine.Xia Qiu gathers, and cleans section, dries.Nature and flavor: bitter, pungent are flat.Cure mainly: removing food stagnancy
Eliminating stagnation, reducing swelling and alleviating pain, relaxing muscles and tendons and activating QI and blood in the collateral.For infantile malnutrition, have a toothache, nervous headache, lymphoid tuberculosis, rheumatic arthritis,
Lumbar muscle strain；Carbuncle furuncle and phyma poison, venom are controlled in external.
Radix Caulophylli: another name: red hair Radix Notoginseng, Wei sternly celestial being, hot pepper seven, Os Gallus domesticus Rhizoma Cimicifugae.Source: for Berberidaceae Paeonia suffruticosa grass platymiscium
Leontice robustumDiels Leontice robustum (Maxim.) Diels [Caulophyllum robustum Maxim.], with root
Shape stem is used as medicine.Autumn excavates, and cleans, and section is dried standby.Nature and flavor: bitter, pungent, temperature.Cure mainly: regulating QI to relieve pain, expelling wind and activating blood circulation.For
Menoxenia, stomach abdomen pain, traumatic injury, rheumatalgia.
Semen Armeniacae Amarum: source: Collective Notes to the Canon of Materia medica.Another name: almond core (" herbal classic "), Fructus Pruni (treatise on Febrile Diseases), wood is begun (" stone
Medicine is elegant "), Semen Armeniacae Amarum (" facing card guide "), Prunus mume var.bungo Makino core (" Zhejiang Chinese medicine handbook ").Source: for rosaceous plant Fructus Pruni or Prunus armeniaca L.var.ansu Maxim.
Dry seed Deng bitter in the mouth.Pluck during fruit maturation in summer, remove sarcocarp and nucleocapsid, take kernel, dry.Put shady and cool being dried to locate,
Anti-moth-eating.Nature and flavor: bitter, temperature, poisonous.1. " herbal classic ": " sweet in the mouth, temperature." 2. " not Lu ": " be bitter, and cold profit is poisonous." 3. " book on Chinese herbal medicine
Just ": " bitter in the mouth is pungent micro-sweet." return through: enter lung, large intestine channel.1. Materia Medica of Decoction: " enter meridian of Hand-TAI YIN." 2. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enters
Spleen, lung two warp." 3. " Thunder God concocts property of medicine solution ": " enters lung, large intestine two warp." cure mainly: expelling phlegm for arresting cough, relieving asthma, intestine moistening.Control diseases caused by exogenous pathogenic factor
Cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation.
Xi: another name: Herba Patriniae, Thalaspi arvense L..Source: Cruciferae Xi platymiscium Xi Thlaspi arvense
L., it is used as medicine with herb and seed.Spring and summer gathers herb, dries；Autumn in summer fruit picking branch, dries, lays seed.Nature and flavor: herb: bitter,
Sweet, flat.Seed: pungent, bitter, tepor.Cure mainly: herb: heat-clearing and toxic substances removing, inducing diuresis and reducing edema, and middle appetizing.For appendicitis, lung abscess,
Carbuncle furuncle and phyma poison, erysipelas, endometritis, leucorrhea, nephritis, cirrhotic ascites, infantile dyspepsia.
Folium et Ramulus Callicarpae nudiflorae: source: " south of the Five Ridges gather medicinal herbs record ".Another name: the reddest (" Nanning City's medicine will "), meal soup leaf, sub-stockaded village are all, big
Cushat rice (" register planted by Guangxi medicine ").Source: for the leaf with twig of Verbenaceae Callicarpa nudiflora.Distribution China south
Portion.Nature and flavor: 1. " Nanning City's medicine will ": " pungent puckery." 2. " Guangdong Chinese medicine " II: " micro-hardship, property is put down." cure mainly: hemostasis, antiinflammatory, dispel
The stasis of blood, pain relieving.That controls that pneumorrhagia type leptospirosis, pulmonary tuberculosis, lung abscess, lobar pneumonia etc. cause is hemorrhage, Peptic Ulcers etc.
The upper gastrointestinal hemorrhage caused, thrombocytopenic purpura, hematuria, wound hemorrhage, influenza, burn, suppurative skin ulcer, son
Cervical erosion, traumatic injury, rheumatalgia.1. " south of the Five Ridges gather medicinal herbs record ": " leaf: decoct washing traumatic injury wound, can eliminating blood stasis to promote regeneration of blood.Such as swelling due to wind,
Leaf is decocted washing, takes its stalk and lean pork decoction, can wind dispelling detumescence." 2. " Nanning City's medicine will ": " stops blooding, pain relieving.Control traumatic injury
Damage, gunshot wound." 3. " register planted by Guangxi medicine ": " dispelling the wind and dampness pathogens."
Radix embeliae laetae: source: " Luchuan book on Chinese herbal medicine ".Another name: white back of the body acid rattan, exceedingly high despot, big gun rattan (" Luchuan book on Chinese herbal medicine "), saturating Pheretima (" south
Peaceful city medicine will "), chicken mother acid, vinegar wood, seabed dragon (" register planted by Guangxi medicine "), enter Pheretima (Guangzhou army " conventional Chinese herbal medicine
Handbook ").Source: for root and the branch and leaf of Myrsinacea plant Fructus embeliae laetae.Root, can adopt the whole year, cleans section, dries.Nature and flavor: acid
Puckery, flat.1. " Luchuan book on Chinese herbal medicine ": " cool in nature, sour in the mouth." 2. " Nanning City's medicine will: " sour and astringent, cold." 3. Guangzhou army " conventional medium-height grass
Medicine handbook ": " sour and astringent, flat." cure mainly: control laryngopharynx swelling and pain, gingiva bleeding gingival hemorrhage, diarrhea due to hypofunction of the spleen, traumatic injury stasis of blood pain, hemorrhoid.1. " Luchuan is originally
Grass ": " antiinflammatory, sterilization.Control stomatitis, laryngitis, gingivitis, furuncle ulcer etc..And solve big tea poison of drug, poison eaten by wood, Fructus Crotonis poison."②
" Nanning City's medicine will ": " parasite killing, detumescence help digestion.External treatment traumatic injury skin infection.Rotten skin ulcer.Take orally and control inside and outside hemorrhoid (and washout), laryngalgia,
Tinea pedis pain (pot Canis familiaris L. foot food)." 3. Guangzhou army " conventional Chinese herbal medicine handbook ": " stasis-dispelling and pain-killing, astringing to arrest diarrhea.Control traumatic injury stasis of blood pain, intestinal
Scorching diarrhoea, laryngopharynx swelling and pain."
Fructus nephelii topengii: source: supplement to the Herbal.Another name: mountain Fructus nephelii topengii (" osmanthus Hai Yu weigh will "), hair Fructus Litchi (" Zhiwu Mingshi Tukao "), hair
Call (" Luchuan book on Chinese herbal medicine ") together.Source: for the fruit of sapindaceous plant Fructus nephelii topengii.Summer gathers.Nature and flavor: 1. supplement to the Herbal: " taste
Sweet, temperature, nontoxic." 2. " Zhiwu Mingshi Tukao ": " sour in the mouth." curing mainly: 1. supplement to the Herbal: " main sudden and violent dysentery, Xin Fuleng." 2. " Luchuan
Book on Chinese herbal medicine ": " shell, anti-inflammation and sterilization.Control stomatitis, dysentery, wash ulcer."
Cladonia fallax Abbayes: source: the Herb of lichens Cladoniaceae Cladonia plant tophus stamen Cladonia fallax Abbayes.Summer
Ji Caishou, decontamination dries.Nature and flavor: bitter are flat.Cure mainly: calm, pain relieving, convergence.For neurasthenia, epilepsy, schizophrenia
Disease, the vertigo, traumatic injury；Burn and scald is controlled in external.
Herba heteropappi crenatifolii: source: " Chinese herbal medicine is commonly used in Tibet ".Another name: its rice (Tibetan name).Source: for feverfew knuckle-tooth Canis familiaris L.
The herb of flower.7～gather August.Nature and flavor: bitter, cold.Cure mainly: detoxicating, relieving inflammation, cough-relieving.Cure cold cough, pharyngalgia, venom.
Radix Sanguisorbae: another name: Matteuccia struthiopteri, beautiful letter, Fructus Choerospondiatis.Source: this product is rosaceous plant Radix Sanguisorbae Sanguisorba
Officinalis L. or Radix Sanguisorbae Sanguisorba off icinalis L.var.longifolia (Bert.) Yu that comes into leaves
The dry root of et Li.The latter practises title " continuous Radix Sanguisorbae ".Spring by during germination or autumn plant withered after excavate, remove fibrous root, wash
Only, it is dried, or takes advantage of fresh slices, be dried.Nature and flavor: bitter, sour, puckery, are slightly cold.Cure mainly: cooling blood for hemostasis, sore of detoxifying.For having blood in stool, hemorrhoid
Blood, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Herba Spirodelae: another name: duckweed, duckweed grass, Herba Spirodelae grass.Source: this product is plant and of its applications duckweed Spirodela
The dry herb of polyrrhiza (L.) Schleid..6～JIUYUE gather, clean, remove impurity, dry.Nature and flavor: pungent, cold.
Gui Jing: return lung meridian.Cure mainly: dispelling wind-heat, rash, diuresis.For measles without adequate eruption, rubella pruritus, edema oliguria.
Folium Malloti Apeltae: another name: wild paulownia, Ye Xiabai, carry on the back wood in vain, carry on the back ma, Bai Piaoshu, white crown in vain.Source: for Euphorbiaceae open country paulownia
Platymiscium Folium Malloti Apeltae Mallotus apelta (Lour.) Muell.-Arg. is used as medicine with root and leaf.Root can be adopted the whole year, cleans,
Section, dries.The many using fresh herbs of leaf, or summer, autumn collection, dry levigation.Nature and flavor: micro-hardship, puckery are flat.Cure mainly: root: easing the affected liver is invigorated blood circulation, spleen invigorating
Removing dampness, convergence is solid de-.For chronic hepatitis, hepatosplenomegaly, uterine prolapse, proctoptosis, leucorrhea, edema during pregnancy.Leaf: anti-inflammation hemostasia.
Otitis media, furuncle and phyma, traumatic injury, traumatic hemorrhage are controlled in external.
Rhizoma Polygonati Odorati: another name: Rhizoma Polygonati Odorati, beautiful ginseng, tail ginseng, bell are as dish, little shaft of a writing brush dish, Herba Hedyotis cantonensis root, Kao Shanzhu.Source: this product is hundred
The dry rhizome of conjunction section plant Rhizoma Polygonati Odorati Polygonatum odoratum (Mill.) Druce.Autumn excavates, and removes fibrous root, washes
Only, shine to after softness, repeatedly rub, dry in the sun to without hard-core, dry；Or after steaming thoroughly, rub to translucent, dry.Nature and flavor: sweet, micro-
Cold.Gui Jing: attach to the lung and stomach meridians.Cure mainly: nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.Hinder for lung stomach-Yin, cough caused by dryness-heat, dry throat and mouth, interior-heat
Quench one's thirst.
Eugenia javanica Lam root: source: medical material Ji Yuan: for the root of myrtle wax jambo.Latin plant animal mineral name:
Syzygium sanarangense (Bl.) Merr. Et Perry gathers and stores: the whole year all can excavate, and cleans, section,
Using fresh herb or dry.Cure mainly: dampness removing；Antipruritic.Main dysuria；Skin pruritus Corydalis gigantea et Meer.: source: begin to be loaded in " northeast plant retrieval
Table ".Source: medical material Ji Yuan: for the herb of bloodroot Corydalis gigantea et Meer..Latin plant animal mineral name: Corydalis
gigantea Trautv.et Mey.[C.gigantea Trautv.et Mey.var.amurensis Regel].Nature and flavor:
Bitter；Cold.Gui Jing: lung；The heart；Liver Channel.Cure mainly: antalgic and sedative；Anti-inflammation.Main various pain.
Rhizoma panacis majoris: another name: pearl ginseng (" detailed outline is picked up any lost article from the road "), Rhizoma Panacis Majoris, pimple seven (" Chinese medicine shape sex experience differential method "), avenge three
Seven (" traditional Chinese medicinal materials assortment discussions "), button seven, Pestalotia funera (" conventional glossary of Herbs and Drugs among the people ").Source: " Bencao Congxin ".Source:
For Araliaceae panax japonicus c.a.mey.var.major (burk.) c.y.wu et k.m.feng in catenate rhizome.Autumn excavates, and removes stem Seedling, fibrous root and thin thin rhizome, dry in the air 6～
7 days, make crust pine steep, or with water logging, then step on crust, well-done in entering pot, or admix proper honey and (per jin add Mel 0.25
Jin), wait boiling time dry to water, taking-up is dried or a heatable brick bed is done.Title button seven that are produced from the ground such as Sichuan is all excavated in spring or autumn, cuts
After stem Seedling, fibrous root and thin thin part, dry and get final product.Nature and flavor: bitter sweet, cold.1. " Bencao Congxin ": " bitter, cold, micro-sweet." 2. " medicine
Material compilation of data ": " taste is the most bitter, carries puckery, is slightly cold, nontoxic." 3. " Traditional Chinese Medicine in Sichuan will ": " is bitter, flat, micro-sweet, nontoxic." return through: " four
River Chinese medicinal herbal ": " enter liver, stomach two warp." cure mainly: yin nourishing, lung heat clearing, dissipating blood stasis, hemostasis, analgesic therapy.Control calentura excessive thirst, cough due to yin deficiency, consumptive disease
Wound is spitted blood, epistaxis, pharyngalgia, rheumatic arthritis, infantile convulsion, traumatic injury.1. " Bencao Congxin ": " tonifying the lung, pathogenic fire reducing.Lung-heat
Person preferably it." 2. " the lifesaving sea of bitterness ": " mass formed by blood stasis with it, can be for Radix Notoginseng." 3. " property of medicine is examined ": " energy Tuoli, outer disease may be used." 4. " Chinese medicine
Shape sex experience differential method ": " strengthening by means of tonics, hemostasia and promoting granulation." 5. " Traditional Chinese Medicine in Sichuan will ": " dissipating blood stasis, hemostasis, analgesic therapy.Control to fall and flutter damage
Wound, consumptive disease wound haematemesis, metrorrhagia hematochezia." 6. " book on Chinese herbal medicine pushes away old ": " controls YinXuXueRe and calentura the moon wound, excessive thirst, cough, pharyngalgia, tooth
Bitterly." 7. " Shaanxi Chinese herbal medicine ": " is relieving convulsion to relieve dizziness, high fever, infantile convulsions, epilepsy, etc., except rheumatism, and stomach invigorating of regulating the flow of vital energy, pain relieving.Control infantile convulsion, rheumatic arthritis, stomach
Bitterly, toxic swelling malignant boil."
Shepherd's purse: source: " not Lu ".Another name:, (" elegant "), Fructus Pruni ginseng (" Bencao Tujing "), Folium Pruni Radix Adenophorae (Radix Glehniae), flour root
(herbal for Relief of Famines), sweet Radix Platycodonis (" detailed outline "), soil Radix Platycodonis (" book on Chinese herbal medicine original "), RADIX ADENOPHORAE (" Bencao Congxin "), Mei Can, come into leaves sand
Ginseng (" Zhejiang conventional medical herbs among the people ").Source: for the root of Campanulaceae shepherd's purse.Nature and flavor: sweet, cold.1. " not Lu ": " sweet, cold."
2. " a thousand pieces of gold wing book on Chinese herbal medicine ": " nontoxic." 3. " Bencao Congxin ": " is sweet light, is slightly cold." return through: 1. " must join book on Chinese herbal medicine ": " starts with lunar
Warp." 2. " book on Chinese herbal medicine is looked for the truth ": " enters lung, spleen." cure mainly: heat clearing away, removing toxic substances, reduce phlegm.Control cough caused by dryness, laryngalgia, quench one's thirst, furuncle swelling toxin.①
" not Lu ": " solve hundred poison of drug." 2. " dietitian's heart mirror ": " profit lung qi, and in, improving eyesight, pain relieving." 3. " Japan hanako materia medica ": " controls snakeworm
Sting, fanatical temperature disease, affix one's name to poisoned arrow." 4. " detailed outline ": " main cough, persistent erection of the penis of quenching one's thirst, sore furuncle swells." 5. " decoction pieces is newly joined ": " is controlled deficient
Lung-heat type cough, born fluid, steaming is moved back in nourishing the stomach." 6. " medicinal herbs among the people of science ": " is suitable for pharyngolaryngitis, acute tracheitis etc., stick-slip
Eliminate the phlegm." 7. " Zhejiang Chinese medicine handbook ": " lung heat clearing fire, dryness-transformation expectorant.Control cough due to lung-heat, treat ambition stagnation of pathogenic heat."
Ramulus Et Folium Adhatodae Vasicae: another name: black leaf Herba Rostellulariae, DAJIEGU.Source: for Acanthaceae Adhatoda Nees plant Ramulus Et Folium Adhatodae Vasicae Admatoda
Ventricosn (Wall.) Nees [Justicia ventricosa Wall.;Cendarussa ventricosa
(Wall.) Nees], it is used as medicine with Herb.The whole year can adopt.Clean, cutting, dry.Nature and flavor: acid pungent, micro-, flat.Cure mainly: Huoxue San "
The stasis of blood, expelling wind and removing dampness.Fracture, traumatic injury, rheumatic arthritis, lumbago and skelalgia, traumatic hemorrhage.
Receptaculum fici Henryi: source: " Jiangxi Chinese medicine ".Another name: cliffstone pomegranate (" Zhiwu Mingshi Tukao "), Ba Lizi, precipice litchi are (in "
State's tree systematics "), Shi Pengpeng (" Jiangxi Chinese medicine "), little Fructus Fici Pumilae (" will planted by Tianmu Mountains of Zhejiang Province medicine "), len-til (Sichuan).Come
Source: for the holder of moraceae plants Radix Thalictri Trichopi.Gather at the beginning of winter, dry.Nature and flavor: " Jiangxi Chinese medicine ": " sweet-puckery flavor, property is put down, nontoxic." main
Control: " Jiangxi Chinese medicine ": " control the testis swelling and hanging down of either of the testes, internal hemorrhoid, have blood in stool."
Herba Vernoniae Cinereae: source: " south of the Five Ridges gather medicinal herbs record ".Another name: ipomoea bonanox, star wipe grass (" south of the Five Ridges gather medicinal herbs record "), posting color, careless (" Guangzhou is planted
Thing will "), perfume (or spice) of returning from the grave (" Guangdong Chinese medicine " II), XIAOSHANHU (Guangzhou army " conventional Chinese herbal medicine handbook "), false salty shrimp, branch Rhizoma et radix valerianae are (extensively
State air force " conventional Chinese herbal medicine handbook ").Source: for the herb of feverfew Herba Vernoniae Cinereae.Gather between summer, autumn herb, dry.Property
Taste: " Guangdong Chinese medicine " II: " cool in nature, lightly seasoned, one says bitter in the mouth, cool in nature." cure mainly: heat clearing away, dehumidifying, removing toxic substances.Control fever caused by exogenous pathogens, acute
Icterohepatitis, damp-heat diarrhea, furuncle swelling toxin.1. " south of the Five Ridges gather medicinal herbs record ": " control fever caused by exogenous pathogens, dehumidifying heat." 2. " Guangdong Chinese medicine "
II: " heat-clearing and toxic substances removing, detumescence and drawing out poison, evacuation of pus.Control damp-heat diarrhea, and control breast ulcer, venom." 3. Guangzhou army " conventional medium-height grass
Medicine handbook ": " liver heat removing is brought down a fever, calmness of calming the nerves.Cure cold heating, cough, acute icterohepatitis, neurasthenia, insomnia, children's
Nocturia, furuncle swelling toxin." 4. " conventional Chinese herbal medicine color atlas ": " controls osteopatia sprain." 5. Guangzhou air force " conventional Chinese herbal medicine hands
Volume ": " control dysentery."
Flos Lonicerae: another name: Flos Lonicerae, Flos Lonicerae, Flos Lonicerae, two precious flowers.Source: this product is caprifoliaceae plant Radix Ophiopogonis Lonicera
Japonica Thunb., Flos Lonicerae Lonicera hypoglauca Miq., Flos Lonicerae (hair calyx Radix Ophiopogonis) Lonicera
The flower that confusa DC. or the dry flower of hair style Radix Ophiopogonis Lonicera dasystyla Rehd. or band just open.Early summer flower
Gather before opening, be dried.Nature and flavor: sweet, cold.Gui Jing: return lung, the heart, stomach warp.Cure mainly: heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle
Furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Fructus Gardeniae: another name: Yellow Fructus Gardeniae, HUANGGUOSHU, SHANZHIZI, Fructus Gardeniae.Source: this product is Maguireothamnus speciosus Fructus Gardeniae
The dry mature fruit of Gardenia jasminoides Ellis, its root also can be used as medicine.9～fruit maturation in November be reddish yellow
Gather during color, remove carpopodium and impurity, steam supreme vapour or put in boiling water boiling the hottest, take out, be dried.Gen Xiaqiu excavates, and cleans and dries.
Nature and flavor: bitter, cold.Gui Jing: GUIXIN, lung, tri-jiao channel.Cure mainly: fruit: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.For calentura
Vexed, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles；External treatment bruise pain.Root: eliminating fire and detoxication, clearly
Diarrhea of heat type is wet, cool the blood dissipate blood stasis.For infectious hepatitis, traumatic injury, acute toothache.
Radix Rumicis Patientiae: source: for the general designation of Polygonaceae Rumex various plants.In addition to curled dock, Radix Rumicis Japonici and rumex dentatus, still
There are Rumex patientia Linn. Rumex patientia L., Rumex chalepensis R. chalepensis Mill. and narrow leaf Radix rumicis acetosae R.
Stenophyllus Ledeb. is all used as medicine with root.Spring, autumn uproot, and remove stem and leaf, clean, and section is dried standby.Nature and flavor: bitter,
Acid, cold.Cure mainly: cooling blood for hemostasis, heat-clearing and toxic substances removing, parasite killing.For dysfunctional uterine hemorrhage, spit blood, spitting of blood, epistaxis, gingival hemorrhage,
Tail, duodenal hemorrhage, have blood in stool, purpura, constipation, edema；Scabies, furuncle, seborrheic dermatitis are controlled in external.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: Herba heteropappi crenatifolii 8-16 weight portion, Xi 12-22
Weight portion, 9-18 weight portion, shepherd's purse 13-31 weight portion, Herba Saussuseae Japonicae 15-25 weight portion, Herba rhynchosiae volubilis 14-36 weight portion, catch up with wind
Bavin 15-25 weight portion, Flos Lonicerae 10-30 weight portion, 12-32 weight portion, Semen Armeniacae Amarum 2-4 weight portion, Radix Rumicis Patientiae 12-34 weight
Part, Fructus nephelii topengii 9-15 weight portion, Eugenia javanica Lam root 11-23 weight portion, Rhizoma panacis majoris 15-28 weight portion, Herba Spirodelae 15-35 weight portion, Herba Vernoniae Cinereae
14-28 weight portion, Radix Sanguisorbae 10-20 weight portion, Rhizoma Polygonati Odorati 16-32 weight portion, Semen Euryales 9-18 weight portion, Fructus Gardeniae 15-45 weight portion, acid
Rattan wood 12-24 weight portion and Radix Caulophylli 9-14 weight portion.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: Herba heteropappi crenatifolii 9-15 weight portion, Xi 14-20
Weight portion, 10-18 weight portion, shepherd's purse 14-30 weight portion, Herba Saussuseae Japonicae 15-25 weight portion, Herba rhynchosiae volubilis 14-35 weight portion, catch up with wind
Bavin 15-25 weight portion, Flos Lonicerae 10-30 weight portion, 14-32 weight portion, Semen Armeniacae Amarum 2-3 weight portion, Radix Rumicis Patientiae 14-34 weight
Part, Fructus nephelii topengii 9-15 weight portion, Eugenia javanica Lam root 12-22 weight portion, Rhizoma panacis majoris 15-28 weight portion, Herba Spirodelae 15-35 weight portion, Herba Vernoniae Cinereae
14-26 weight portion, Radix Sanguisorbae 10-20 weight portion, Rhizoma Polygonati Odorati 18-30 weight portion, Semen Euryales 10-18 weight portion, Fructus Gardeniae 15-45 weight portion,
Radix embeliae laetae 12-23 weight portion and Radix Caulophylli 10-14 weight portion.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: Herba heteropappi crenatifolii 12 weight portion, Xi 16 weight
Part, 10 weight portions, shepherd's purse 25 weight portion, Herba Saussuseae Japonicae 17 weight portion, Herba rhynchosiae volubilis 33 weight portion, Folium et Ramulus Callicarpae nudiflorae 20 weight portion, gold silver
Spend 15 weight portions, 26 weight portions, Semen Armeniacae Amarum 2 weight portion, Radix Rumicis Patientiae 33 weight portion, Fructus nephelii topengii 13 weight portion, Eugenia javanica Lam root 21 weight
Part, Rhizoma panacis majoris 25 weight portion, Herba Spirodelae 32 weight portion, Herba Vernoniae Cinereae 24 weight portion, Radix Sanguisorbae 15 weight portion, Rhizoma Polygonati Odorati 30 weight portion, Semen Euryales
15 weight portions, Fructus Gardeniae 42 weight portion, Radix embeliae laetae 22 weight portion and Radix Caulophylli 13 weight portion.
The raw medicinal material of described pharmaceutical composition also includes: Folium Malloti Apeltae, Ramulus Et Folium Adhatodae Vasicae, Corydalis gigantea et Meer., Receptaculum fici Henryi and Cladonia fallax Abbayes.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: Herba heteropappi crenatifolii 9-15 weight portion, Xi 14-20
Weight portion, 10-18 weight portion, shepherd's purse 14-30 weight portion, Herba Saussuseae Japonicae 15-25 weight portion, Herba rhynchosiae volubilis 14-35 weight portion, catch up with wind
Bavin 15-25 weight portion, Flos Lonicerae 10-30 weight portion, 14-32 weight portion, Semen Armeniacae Amarum 2-3 weight portion, Radix Rumicis Patientiae 14-34 weight
Part, Fructus nephelii topengii 9-15 weight portion, Eugenia javanica Lam root 12-22 weight portion, Rhizoma panacis majoris 15-28 weight portion, Herba Spirodelae 15-35 weight portion, Herba Vernoniae Cinereae
14-26 weight portion, Radix Sanguisorbae 10-20 weight portion, Rhizoma Polygonati Odorati 18-30 weight portion, Semen Euryales 10-18 weight portion, Fructus Gardeniae 15-45 weight portion,
Radix embeliae laetae 12-23 weight portion, Radix Caulophylli 10-14 weight portion, Folium Malloti Apeltae 10-14 weight portion, Ramulus Et Folium Adhatodae Vasicae 10-14 weight portion, huge purple
Violet 2-4 weight portion, Receptaculum fici Henryi 14-36 weight portion and Cladonia fallax Abbayes 10-20 weight portion.
Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: Herba heteropappi crenatifolii 12 weight portion, Xi 16 weight
Part, 10 weight portions, shepherd's purse 25 weight portion, Herba Saussuseae Japonicae 17 weight portion, Herba rhynchosiae volubilis 33 weight portion, Folium et Ramulus Callicarpae nudiflorae 20 weight portion, gold silver
Spend 15 weight portions, 26 weight portions, Semen Armeniacae Amarum 2 weight portion, Radix Rumicis Patientiae 33 weight portion, Fructus nephelii topengii 13 weight portion, Eugenia javanica Lam root 21 weight
Part, Rhizoma panacis majoris 25 weight portion, Herba Spirodelae 32 weight portion, Herba Vernoniae Cinereae 24 weight portion, Radix Sanguisorbae 15 weight portion, Rhizoma Polygonati Odorati 30 weight portion, Semen Euryales
15 weight portions, Fructus Gardeniae 42 weight portion, Radix embeliae laetae 22 weight portion, Radix Caulophylli 13 weight portion, Folium Malloti Apeltae 12 weight portion, Ramulus Et Folium Adhatodae Vasicae 10 weight
Amount part, Corydalis gigantea et Meer. 3 weight portion, Receptaculum fici Henryi 35 weight portion and Cladonia fallax Abbayes 20 weight portion.
When the dosage form of described pharmaceutical composition is granule, its preparation method comprises the following steps:
The first step, is mixed described raw medicinal material in described ratio, add relative to the determining alcohol of mixture 4～8 times be 85%～
The ethanol of 95%, is heated to boiling reflux 3～5 hours, filters, use percolation with per minute 1～2ml speed slowly percolation,
Collect percolate, when being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa relative density be 1.04～
The mastic of 1.10, is spray-dried, the inlet temperature 160 of spray dryer～175 DEG C, leaving air temp 80～85 DEG C, pulverizes subsequently
Become powder, make dried cream powder；
Second step, adds relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times and 0.1～0.2 times in the dried cream powder obtained
Dextrin, make granule, in 40～50 DEG C be dried, it is thus achieved that granule.
When the dosage form of described pharmaceutical composition is injectable powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, puts into and is ground into 0.1～10 μm volume average particle in super micron mill
The mixed powder that the micron particles in footpath and particle diameter form less than the nano-scale particle of 0.1 μm volume average particle size, described mixing
The powder rate that obtains of powder is at least 95%；
Second step, adds the quality 3 relative to described mixed powder～the determining alcohol of 5 times in the mixed powder that the first step obtains
Being the ethanol of 85%～95%, stirring and dissolving obtains ethanol solution, and ethanol solution stands under conditions of 5 DEG C～10 DEG C 24～36
Hour, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, be concentrated and dried, and put at this
Super micron mill is pulverized 40～60 minutes, it is thus achieved that the micron particles of 0.1～10 μm volume average particle size and particle diameter are less than 0.1
The mixed powder of the nano-scale particle composition of μm volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection,
Stirring makes it dissolve, and injects water to 1000ml further, adds 1g～1.5g needle-use activated carbon, is sufficiently stirred for 30～50
Minute；Decarbonization filtering；With 0.22～0.24 μm filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding.
When the dosage form of described pharmaceutical composition is ointment, and preparation method comprises the following steps:
The first step, according to ratio of weight and number weigh Xi, shepherd's purse, Herba Saussuseae Japonicae and Herba rhynchosiae volubilis, add above-mentioned raw materials medicine medical material total
The water of weight 5-10 times amount, soaks 1-2 hour, extracts the volatile oil of 2-5 hour, and extracting method is steam distillation or super faces
Boundary's extraction extracts, and collects volatile oil, and medicinal liquid filters, and medicinal residues are standby；
Second step, weighs surplus stock medical material according to ratio of weight and number, mixes with the medicinal residues in step (1), total after putting into mixing
In the ethanol of the 95% of weight 6-8 times amount, soak 2 hours；After immersion, at 70～80 DEG C, heat is extracted, and obtains extracting solution 1, and medicinal residues are standby
With;
3rd step, adds in the ethanol of 85% of medicinal residues gross weight 5～8 times amount, heating and refluxing extraction 2 in the medicinal residues of step (2)
Secondary, each 1～2 hour, 2 extracting solution are merged and stands, obtain extracting solution 2, medicinal residues are standby；
4th step, will add the water of 5～8 times amount of medicinal residues weight in the medicinal residues of step (3), heating and refluxing extraction 2 times, each 2 little
Time, 2 extracting solution are merged and stands, obtain extracting solution 3；
5th step, merges extracting solution 1, extracting solution 2 and extracting solution 3, and when concentrating under reduced pressure obtains 80 DEG C, relative density is the filter of 1.35
Liquid, reclaims ethanol, and by gained filtrate adjustment proportion to when 80 DEG C 1.06, reduce pressure to obtain extractum, glycerol adding furnishing ointment.
Embodiment is below used to describe embodiments of the present invention in detail, whereby to the present invention how application technology means
Solve technical problem, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 granule
The preparation process of granule of the present invention is: take Herba heteropappi crenatifolii 12 weight portion, Xi 16 weight portion, 10 weight portions, shepherd's purse
25 weight portions, Herba Saussuseae Japonicae 17 weight portion, Herba rhynchosiae volubilis 33 weight portion, Folium et Ramulus Callicarpae nudiflorae 20 weight portion, Flos Lonicerae 15 weight portion, 26 weight
Part, Semen Armeniacae Amarum 2 weight portion, Radix Rumicis Patientiae 33 weight portion, Fructus nephelii topengii 13 weight portion, Eugenia javanica Lam root 21 weight portion, Rhizoma panacis majoris 25 weight portion, Herba Spirodelae
32 weight portions, Herba Vernoniae Cinereae 24 weight portion, Radix Sanguisorbae 15 weight portion, Rhizoma Polygonati Odorati 30 weight portion, Semen Euryales 15 weight portion, Fructus Gardeniae 42 weight portion,
Radix embeliae laetae 22 weight portion and Radix Caulophylli 13 weight portion；
The first step, is mixed described raw medicinal material in described ratio, adds the ethanol that determining alcohol is 90% relative to 5 times of mixture,
It is heated to boiling reflux 4 hours, filters, use percolation with the speed slowly percolation of 2ml per minute, collect percolate, subsequently
Being evaporated to relative density when 55 DEG C under vacuum 0.067Mpa is the mastic of 1.05, is spray-dried, spray dryer
Inlet temperature 170 DEG C, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder；
Second step, adds the cane sugar powder relative to dried cream powder quality 0.3 times and the dextrin of 0.15 times in the dried cream powder obtained, system
Become granule, be dried in 45 DEG C, it is thus achieved that granule.
Embodiment 2 injectable powder
The preparation process of injectable powder of the present invention is: take Herba heteropappi crenatifolii 14 weight portion, Xi 18 weight portion, 12 weight portions, shepherd's purse
25 weight portions, Herba Saussuseae Japonicae 23 weight portion, Herba rhynchosiae volubilis 32 weight portion, Folium et Ramulus Callicarpae nudiflorae 22 weight portion, Flos Lonicerae 30 weight portion, 28 weight
Part, Semen Armeniacae Amarum 2 weight portion, Radix Rumicis Patientiae 33 weight portion, Fructus nephelii topengii 13 weight portion, Eugenia javanica Lam root 20 weight portion, Rhizoma panacis majoris 17 weight portion, Herba Spirodelae
32 weight portions, Herba Vernoniae Cinereae 24 weight portion, Radix Sanguisorbae 15 weight portion, Rhizoma Polygonati Odorati 30 weight portion, Semen Euryales 15 weight portion, Fructus Gardeniae 42 weight portion,
Radix embeliae laetae 20 weight portion and Radix Caulophylli 13 weight portion；
The first step, is mixed in proportion described raw medicinal material, puts into and is ground into 0.7 μm volume average particle size in super micron mill
The mixed powder that micron particles and particle diameter form less than the nano-scale particle of 0.1 μm volume average particle size, described mixed powder
Powder rate be at least 95%；
Second step, the determining alcohol adding the quality 4 times relative to described mixed powder in the mixed powder that the first step obtains is
The ethanol of 95%, stirring and dissolving obtain ethanol solution, ethanol solution is stood 32 hours under conditions of 7 DEG C, employing percolation with
The speed of 2ml per minute slowly percolation, collects percolate, is concentrated and dried, and puts into pulverizing 50 points in super micron mill at this
Clock, it is thus achieved that the micron particles of 0.7 μm volume average particle size and particle diameter are less than the nano-scale particle group of 0.1 μm volume average particle size
The mixed powder become, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes the mixed powder 20g that second step obtains, and adds propylene glycol 40g, adds 200ml water for injection, and stirring makes it molten
Solve, inject water to 1000ml further, add 1.5g needle-use activated carbon, be sufficiently stirred for 40 minutes；Decarbonization filtering；With
0.23 μm filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding.
Embodiment 3 ointment
The preparation process of ointment of the present invention is: take Herba heteropappi crenatifolii 12 weight portion, Xi 16 weight portion, 10 weight portions, shepherd's purse
25 weight portions, Herba Saussuseae Japonicae 17 weight portion, Herba rhynchosiae volubilis 33 weight portion, Folium et Ramulus Callicarpae nudiflorae 20 weight portion, Flos Lonicerae 15 weight portion, 26 weight
Part, Semen Armeniacae Amarum 2 weight portion, Radix Rumicis Patientiae 33 weight portion, Fructus nephelii topengii 13 weight portion, Eugenia javanica Lam root 21 weight portion, Rhizoma panacis majoris 25 weight portion, Herba Spirodelae
32 weight portions, Herba Vernoniae Cinereae 24 weight portion, Radix Sanguisorbae 15 weight portion, Rhizoma Polygonati Odorati 30 weight portion, Semen Euryales 15 weight portion, Fructus Gardeniae 42 weight portion,
Radix embeliae laetae 22 weight portion, Radix Caulophylli 13 weight portion, Folium Malloti Apeltae 12 weight portion, Ramulus Et Folium Adhatodae Vasicae 10 weight portion, Corydalis gigantea et Meer. 3 weight portion, stone
Peng Zi 35 weight portion and Cladonia fallax Abbayes 20 weight portion；
The first step, according to ratio of weight and number weigh Xi, shepherd's purse, Herba Saussuseae Japonicae and Herba rhynchosiae volubilis, add above-mentioned raw materials medicine medical material total
The water of weight 8 times amount, soaks 1.5 hours, extracts the volatile oil of 3 hours, and extracting method is steam distillation or supercritical extraction
Following the example of extraction, collect volatile oil, medicinal liquid filters, and medicinal residues are standby；
Second step, weighs surplus stock medical material according to ratio of weight and number, mixes with the medicinal residues in step (1), total after putting into mixing
In the ethanol of the 95% of weight 7 times amount, soak 2 hours；After immersion, at 70 DEG C, heat is extracted, and obtains extracting solution 1, and medicinal residues are standby;
3rd step, adds in the ethanol of 85% of medicinal residues gross weight 6 times amount in the medicinal residues of step (2), heating and refluxing extraction 2 times,
Each 1 hour, being merged by 2 extracting solution and stand, obtain extracting solution 2, medicinal residues are standby；
4th step, will add the water of 4 times amount of medicinal residues weight in the medicinal residues of step (3), heating and refluxing extraction 2 times, each 2 hours,
2 extracting solution are merged and stands, obtain extracting solution 3；
5th step, merges extracting solution 1, extracting solution 2 and extracting solution 3, and when concentrating under reduced pressure obtains 80 DEG C, relative density is the filter of 1.35
Liquid, reclaims ethanol, and by gained filtrate adjustment proportion to when 80 DEG C 1.06, reduce pressure to obtain extractum, glycerol adding furnishing ointment.
Injection toxicity test:
(1) animal selects
Cleaning grade kunming mice 40, male and female half and half, body weight 18-22 g；Laboratory observation 1 week, fasting 4 h before being every time administered,
Can't help water.
(2) test packet
By above cleaning grade kunming mice laboratory observation 1 week, the cleaning grade kunming mice that clinical observation result is healthy was random
It is divided into two groups, often 20 (male and female half and half) of group.One of which is set as experimental group, and another group is set as matched group.
(3) medication and dosage
Mouse tail vein injection, experimental group is to give continuously in maximum (former) concentration of the embodiment of the present invention 2 and maximum volume 24 h
Medicine 3 times, gives 0.6 ml/20g(Mouse Weight) medicine, the injection 1.8g of mouse tail vein injection embodiment 1 in i.e. 24 h
(crude drug amount)/20g(Mouse Weight)；Matched group is to the injection normal saline of same volume.
(4) observational technique and index
Weigh the weight of animals before being administered and observe feed intake and drinking-water situation；After administration, every day weighs animal body in the identical time
Weight, feed intake and undue toxicity's symptom, Continuous Observation 14 d.Observation index is as follows: 1. take action, as unease, many dynamic, send out
Sound；2. nervous system reaction, as lifted tail, chatter, spasm, movement disorder, attitude extremely；3. autonomic nervous system reaction, such as eye
Ball is prominent, sialorrhea, shed tears, urinate, drop, perpendicular hair, dyschromasia, adnormal respiration；4. drinking-water and appetite change, defecation and
Color, whether nose, eye, oral cavity be with or without abnormal secretion thing, body weight change；5. death condition.
(5) experimental result
By the observation of 14 d, two groups all do not have undue toxicity to react appearance, the most do not occur animal dead phenomenon.Cause
This, the injection of the embodiment of the present invention 2 has no side effect.
Acute toxicity test: application NIH mice 40, S fully recovers F level, male and female half and half, and body weight 18～25g carries out acute poison
Property test.Mice is randomly divided into two groups, often group 20, i.e. matched group and administration group, fasting 12 hours before experiment；By the present invention's
The granule of embodiment 1 preparation is dissolved in water, and (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is
5ml/kg(i.e. unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, within one day, is administered 2 times, between administration
6 hours intervals, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Test result indicate that: with
Matched group compares, and after administration, mice has no notable difference, experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body
Heavily increase the most normal.Granule LD50 > 28.7 crude drugs/the kg of the Mouse oral gavage present invention, every day, maximum dosage-feeding was 57.4
Crude drug/kg/ day.The pharmaceutical composition clinical application amount of the present invention is 4.6g crude drug/day/people, and adult's body weight is in terms of 60KG, averagely
Dosage is 0.077g crude drug/kg/ day.By weighing machine: the medicine of mice (average weight is in terms of 21g) the oral administration gavage present invention
The dosis tolerata of compositions is 745 times of quantity.Therefore the pharmaceutical composition acute toxicity of the present invention is low, and clinical application is pacified
Entirely.
Pharmacology pharmacodynamic is tested:
1, acute skin irritation test:
With the ointment of the embodiment of the present invention 3 as object, these product are according to Ministry of Public Health " cosmetics health specification " (2002) second
Dividing 6.3 joint in " skin irritation/corrosion test ", male 8 of Japan large ear rabbit, body weight 2kg～3kg, according to above-mentioned " anxious
Property percutaneous toxicity test " method, prepare coating, then take 0.3g and directly spread upon (opposite side conduct on skin on the left of animal
Comparison), use blocking test, 4 hours application time, after off-test, remain tested material with warm water washing, in removing tested material
Rear 12h, 24h, 48h and 72h observe the tested district of animal and the dermoreaction of check plot respectively, and top average is " 0 ", it is judged that
These product are to animal skin nonirritant.
2, acute toxicity test: with the granule of the embodiment of the present invention 1 as object, gives white mouse for 150 times of clinical consumption per day
Big enteral dispensing, observes 14.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no malicious
Property reaction.White mouse vagina and damaged skin are carried out irritation test, there are no irritative response and other untoward reaction.Toxicity
Test proves, the most toxic effect of this medicine and untoward reaction, clinical practice is safe and reliable.
Clinical data
1, data and method
1.1 physical data: during selecting in July ,-2014 in July, 2013, the tinea pedis of my institute's diagnosis and treatment totally 200 example, wherein, man 134
Example, female 66 example, less than 20 years old age person 62 example, 20-45 year person 73 example, more than 45 years old 65 examples.Additionally 200 example patients are divided at random
For Granules in Treating group, injectable powder treatment group, ointment treatment group and matched group；Often organizing 50 people, four groups of patients are in age, property
Not, state of an illness weight aspect comparing difference not statistically significant, there is comparability, and according to the weight out-patient treatment of the state of an illness.
Clinical manifestation:
Toe is wet rotten, and decortication, the symptom of breach occurs in foot；Blister wastes the rotten position having and is dried, peels, and some positions are wasted rotten
Flowing water, between toe, the toe back of the body and instep is red and swollen, rotten to the corn and ooze out, be often accompanied by lymphangitis and lymphadenitis, white feel that expectorant is itched and pain.
Diagnostic criteria:
(1) pars affecta skin be dried, desquamation, hyperkeratosis, so that substantially thickening, winter easily chaps.(2) affected part occur cluster or
Be dispersed in is deep in water scar, is difficult to wear out, and gargalesthesia is obvious.Water scar absorbs after there is a few days naturally, surface desquamation.Rise one after another, instead
Recurrence is made.
(3) heel edge is common ringwise or arc shape small pieces pimple group.Pruritus is obvious, has squamous desquamation.The centre of the palm and
Also can occur between finger, Xia Chongdong is light.
(4) interdigit is common has wet rotten, and epidermis is moist, macerate, color is white, and after stripping off, visible substrate is scarlet and rotten to the corn, pruritus
Heavier.Can secondary bacterial infection and foul smelling.
The standard of curative effect evaluation: recovery from illness: deflorescence, gargalesthesia disappear, keratinization type chapped skin disappears, fungus microscope examination and cultivation
Negative.Effective: erythra reduces more than 60%, gargalesthesia substantially alleviates, keratinization type chapped skin alleviates, negative fungal examination or visible
The mycelia that a small amount of deformation is broken.Invalid: deflorescence is less than 20%, and pruritus does not alleviates or increases the weight of, and chapped skin alleviates, fungus mirror
Examine the mycelia that negative or visible a small amount of deformation is broken.
In medication therapy groups:
Granules in Treating group: use the embodiment of the present invention 1 to prepare granule, three times a day, once a bag, every bag of 6g, within every 7 days, be
One course for the treatment of；
Injectable powder treatment group: use the injectable powder intravenous drip of the embodiment of the present invention 2 preparation, the most molten with appropriate water for injection
Solving, then dilute with 5% glucose injection 500ml, every day 1 time, each per kilogram of body weight 30mg, every 7 days is a course for the treatment of；
Ointment treatment group: use the embodiment of the present invention 3 to prepare ointment, every day 2 times, the most once, every 7 days be a treatment
Journey；
Matched group: use clotrimazole ointment, 2 mg, every day 2 times, the most once, every 7 days be a course for the treatment of.
Therapeutic outcome:
See Tables 1 and 2, as it can be seen from table 1 use the medicine composite for curing tinea pedis of the present invention, relative to conventional medicament
On therapeutic effect, have and be markedly improved；From table 2 it can be seen that use the medicine composite for curing tinea pedis of the present invention, relatively
In conventional medicament, significantly shorten on the course for the treatment of treating.
Table 1 is respectively organized and is treated Clinical efficacy comparison example after 4 courses for the treatment of respectively
| Group | Number of cases | Cure number | Significant figure | Invalid number | Total effective rate (%) |
| Granules in Treating group | 50 | 40 | 9 | 1 | 98% |
| Injectable powder treatment group | 50 | 42 | 7 | 1 | 98% |
| Ointment treatment group | 50 | 45 | 5 | 0 | 100% |
| Matched group | 50 | 17 | 21 | 12 | 76% |
Table 2 is respectively organized after treating 4 courses for the treatment of respectively and is cured and efficiently individual quantity time comparative example (%)
| Group | Number of cases | 1st course for the treatment of | 2nd course for the treatment of | 3rd course for the treatment of | 4th course for the treatment of |
| Granules in Treating group | 49 | 11(22.4%) | 12(24.5%) | 13(26.5%) | 13(26.5%) |
| Injectable powder treatment group | 49 | 11(22.4%) | 12(24.5%) | 13(26.5%) | 13(26.5%) |
| Ointment treatment group | 50 | 12(24%) | 12(24%) | 13(26%) | 13(26%) |
| Matched group | 38 | 3(7.9%) | 5(13.2%) | 7(18.4%) | 23(60.5%) |
According to the clinical statistics in above table, the treatment tinea pedis medicine compositions that the present invention provides, have rapid-action, have
Efficiency height, determined curative effect, safety is high, have no side effect；Simultaneously to the healing for the treatment of group, 148 examples of efficiently individual quantity and comparison
Group cure, effective 38 example follow-up of patients 1 year half, result add up, Granules in Treating group 49 example is cured 40 examples without recurrence, effective 9
Recurring 2 examples in example, relapse rate is 4.1%；Injectable powder treatment group 49 example cures 42 examples without recurrence, 1 case relapsed in effective 7 examples, multiple
The rate of sending out is 2%；In 50 examples of ointment treatment group, more 45 examples, effective 5 examples are all without recurrence, relapse rate 0%；17 cured in matched group
Example patient is recurred 9 examples, effective 21 example patients recur 13 examples, relapse rate 57.9%；Above-mentioned recurrence refers to patient outcomes
After reaching to cure or be effective, 1 year half followed up a case by regular visits to substantially occurs the symptom before treatment.
Model case: Wang, man, 40 years old, interdigit is common to be had wet rotten, and epidermis is moist, macerate, color is white, the most visible after stripping off
Substrate is scarlet and rotten to the corn, and pruritus is heavier, through being diagnosed as tinea pedis；Use the granule of the embodiment of the present invention 1, three times a day, one time one
Bag, uses substantially cure a course for the treatment of, continues medication two weeks and cures, follows up a case by regular visits to not recur for 1 year half.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and
Within principle, any amendment, the equivalent made, enter, should be included within the scope of the present invention.
Claims (10)
1. the pharmaceutical composition treating tinea pedis, it is characterised in that described pharmaceutical composition is made up of following raw medicinal material: road
Other chrysanthemum, Xi, shepherd's purse, Herba Saussuseae Japonicae, Herba rhynchosiae volubilis, Folium et Ramulus Callicarpae nudiflorae, Flos Lonicerae, Semen Armeniacae Amarum, Radix Rumicis Patientiae, Fructus nephelii topengii, Eugenia javanica Lam root, pearl
Youngster's ginseng, Herba Spirodelae, Herba Vernoniae Cinereae, Radix Sanguisorbae, Rhizoma Polygonati Odorati, Semen Euryales, Fructus Gardeniae, Radix embeliae laetae and Radix Caulophylli.
The pharmaceutical composition for the treatment of tinea pedis the most according to claim 1, it is characterised in that described pharmaceutical composition is by following
The raw medicinal material of parts by weight is made: Herba heteropappi crenatifolii 8-16 weight portion, Xi 12-22 weight portion, 9-18 weight portion, shepherd's purse
13-31 weight portion, Herba Saussuseae Japonicae 15-25 weight portion, Herba rhynchosiae volubilis 14-36 weight portion, Folium et Ramulus Callicarpae nudiflorae 15-25 weight portion, Flos Lonicerae 10-30 weight
Amount part, 12-32 weight portion, Semen Armeniacae Amarum 2-4 weight portion, Radix Rumicis Patientiae 12-34 weight portion, Fructus nephelii topengii 9-15 weight portion, Eugenia javanica Lam root 11-
23 weight portions, Rhizoma panacis majoris 15-28 weight portion, Herba Spirodelae 15-35 weight portion, Herba Vernoniae Cinereae 14-28 weight portion, Radix Sanguisorbae 10-20 weight portion,
Rhizoma Polygonati Odorati 16-32 weight portion, Semen Euryales 9-18 weight portion, Fructus Gardeniae 15-45 weight portion, Radix embeliae laetae 12-24 weight portion and Radix Caulophylli 9-14
Weight portion.
The pharmaceutical composition for the treatment of tinea pedis the most according to claim 1 and 2, it is characterised in that described pharmaceutical composition by
The raw medicinal material of following parts by weight is made: Herba heteropappi crenatifolii 9-15 weight portion, Xi 14-20 weight portion, 10-18 weight portion,
Shepherd's purse 14-30 weight portion, Herba Saussuseae Japonicae 15-25 weight portion, Herba rhynchosiae volubilis 14-35 weight portion, Folium et Ramulus Callicarpae nudiflorae 15-25 weight portion, Flos Lonicerae 10-
30 weight portions, 14-32 weight portion, Semen Armeniacae Amarum 2-3 weight portion, Radix Rumicis Patientiae 14-34 weight portion, Fructus nephelii topengii 9-15 weight portion, Eugenia javanica Lam
Root 12-22 weight portion, Rhizoma panacis majoris 15-28 weight portion, Herba Spirodelae 15-35 weight portion, Herba Vernoniae Cinereae 14-26 weight portion, Radix Sanguisorbae 10-20 weight
Amount part, Rhizoma Polygonati Odorati 18-30 weight portion, Semen Euryales 10-18 weight portion, Fructus Gardeniae 15-45 weight portion, Radix embeliae laetae 12-23 weight portion and red hair
Seven 10-14 weight portions.
4. according to the pharmaceutical composition of the treatment tinea pedis described in any one of claim 1-3, it is characterised in that described drug regimen
Thing is made up of the raw medicinal material of following parts by weight: Herba heteropappi crenatifolii 12 weight portion, Xi 16 weight portion, 10 weight portions, shepherd's purse
25 weight portions, Herba Saussuseae Japonicae 17 weight portion, Herba rhynchosiae volubilis 33 weight portion, Folium et Ramulus Callicarpae nudiflorae 20 weight portion, Flos Lonicerae 15 weight portion, 26 weight
Part, Semen Armeniacae Amarum 2 weight portion, Radix Rumicis Patientiae 33 weight portion, Fructus nephelii topengii 13 weight portion, Eugenia javanica Lam root 21 weight portion, Rhizoma panacis majoris 25 weight portion, Herba Spirodelae
32 weight portions, Herba Vernoniae Cinereae 24 weight portion, Radix Sanguisorbae 15 weight portion, Rhizoma Polygonati Odorati 30 weight portion, Semen Euryales 15 weight portion, Fructus Gardeniae 42 weight portion,
Radix embeliae laetae 22 weight portion and Radix Caulophylli 13 weight portion.
5. according to the pharmaceutical composition of the treatment tinea pedis described in any one of claim 1-4, it is characterised in that described drug regimen
The raw medicinal material of thing also includes: Folium Malloti Apeltae, Ramulus Et Folium Adhatodae Vasicae, Corydalis gigantea et Meer., Receptaculum fici Henryi and Cladonia fallax Abbayes.
6. according to the pharmaceutical composition of the treatment tinea pedis described in any one of claim 1-5, it is characterised in that described drug regimen
Thing is made up of the raw medicinal material of following parts by weight: Herba heteropappi crenatifolii 9-15 weight portion, Xi 14-20 weight portion, 10-18 weight
Part, shepherd's purse 14-30 weight portion, Herba Saussuseae Japonicae 15-25 weight portion, Herba rhynchosiae volubilis 14-35 weight portion, Folium et Ramulus Callicarpae nudiflorae 15-25 weight portion, Flos Lonicerae
10-30 weight portion, 14-32 weight portion, Semen Armeniacae Amarum 2-3 weight portion, Radix Rumicis Patientiae 14-34 weight portion, Fructus nephelii topengii 9-15 weight portion, lotus
Mist root 12-22 weight portion, Rhizoma panacis majoris 15-28 weight portion, Herba Spirodelae 15-35 weight portion, Herba Vernoniae Cinereae 14-26 weight portion, Radix Sanguisorbae 10-20
Weight portion, Rhizoma Polygonati Odorati 18-30 weight portion, Semen Euryales 10-18 weight portion, Fructus Gardeniae 15-45 weight portion, Radix embeliae laetae 12-23 weight portion, red hair
Seven 10-14 weight portions, Folium Malloti Apeltae 10-14 weight portion, Ramulus Et Folium Adhatodae Vasicae 10-14 weight portion, Corydalis gigantea et Meer. 2-4 weight portion, Receptaculum fici Henryi 14-36
Weight portion and Cladonia fallax Abbayes 10-20 weight portion.
7. according to the pharmaceutical composition of the treatment tinea pedis described in any one of claim 1-6, it is characterised in that described drug regimen
Thing is made up of the raw medicinal material of following parts by weight: Herba heteropappi crenatifolii 12 weight portion, Xi 16 weight portion, 10 weight portions, shepherd's purse
25 weight portions, Herba Saussuseae Japonicae 17 weight portion, Herba rhynchosiae volubilis 33 weight portion, Folium et Ramulus Callicarpae nudiflorae 20 weight portion, Flos Lonicerae 15 weight portion, 26 weight
Part, Semen Armeniacae Amarum 2 weight portion, Radix Rumicis Patientiae 33 weight portion, Fructus nephelii topengii 13 weight portion, Eugenia javanica Lam root 21 weight portion, Rhizoma panacis majoris 25 weight portion, Herba Spirodelae
32 weight portions, Herba Vernoniae Cinereae 24 weight portion, Radix Sanguisorbae 15 weight portion, Rhizoma Polygonati Odorati 30 weight portion, Semen Euryales 15 weight portion, Fructus Gardeniae 42 weight portion,
Radix embeliae laetae 22 weight portion, Radix Caulophylli 13 weight portion, Folium Malloti Apeltae 12 weight portion, Ramulus Et Folium Adhatodae Vasicae 10 weight portion, Corydalis gigantea et Meer. 3 weight portion, stone
Peng Zi 35 weight portion and Cladonia fallax Abbayes 20 weight portion.
8. according to the preparation method of the pharmaceutical composition of the treatment tinea pedis described in any one of claim 1-7, it is characterised in that when
When the dosage form of described pharmaceutical composition is granule, its preparation method comprises the following steps:
The first step, is mixed described raw medicinal material in described ratio, add relative to the determining alcohol of mixture 4～8 times be 85%～
The ethanol of 95%, is heated to boiling reflux 3～5 hours, filters, use percolation with per minute 1～2ml speed slowly percolation,
Collect percolate, when being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa relative density be 1.04～
The mastic of 1.10, is spray-dried, the inlet temperature 160 of spray dryer～175 DEG C, leaving air temp 80～85 DEG C, pulverizes subsequently
Become powder, make dried cream powder；
Second step, adds relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times and 0.1～0.2 times in the dried cream powder obtained
Dextrin, make granule, in 40～50 DEG C be dried, it is thus achieved that granule.
9. according to the preparation method of the pharmaceutical composition of the treatment tinea pedis described in any one of claim 1-7, it is characterised in that when
When the dosage form of described pharmaceutical composition is injectable powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, puts into and is ground into 0.1～10 μm volume average particle in super micron mill
The mixed powder that the micron particles in footpath and particle diameter form less than the nano-scale particle of 0.1 μm volume average particle size, described mixing
The powder rate that obtains of powder is at least 95%；
Second step, adds the quality 3 relative to described mixed powder～the determining alcohol of 5 times in the mixed powder that the first step obtains
Being the ethanol of 85%～95%, stirring and dissolving obtains ethanol solution, and ethanol solution stands under conditions of 5 DEG C～10 DEG C 24～36
Hour, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, be concentrated and dried, and put at this
Super micron mill is pulverized 40～60 minutes, it is thus achieved that the micron particles of 0.1～10 μm volume average particle size and particle diameter are less than 0.1
The mixed powder of the nano-scale particle composition of μm volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection,
Stirring makes it dissolve, and injects water to 1000ml further, adds 1g～1.5g needle-use activated carbon, is sufficiently stirred for 30～50
Minute；Decarbonization filtering；With 0.22～0.24 μm filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding.
10. according to the preparation method of the pharmaceutical composition of the treatment tinea pedis described in any one of claim 1-7, it is characterised in that
When the dosage form of described pharmaceutical composition is ointment, and preparation method comprises the following steps:
The first step, according to ratio of weight and number weigh Xi, shepherd's purse, Herba Saussuseae Japonicae and Herba rhynchosiae volubilis, add above-mentioned raw materials medicine medical material total
The water of weight 5-10 times amount, soaks 1-2 hour, extracts the volatile oil of 2-5 hour, and extracting method is steam distillation or super faces
Boundary's extraction extracts, and collects volatile oil, and medicinal liquid filters, and medicinal residues are standby；
Second step, weighs surplus stock medical material according to ratio of weight and number, mixes with the medicinal residues in step (1), total after putting into mixing
In the ethanol of the 95% of weight 6-8 times amount, soak 2 hours；After immersion, at 70～80 DEG C, heat is extracted, and obtains extracting solution 1, and medicinal residues are standby
With;
3rd step, adds in the ethanol of 85% of medicinal residues gross weight 5～8 times amount, heating and refluxing extraction 2 in the medicinal residues of step (2)
Secondary, each 1～2 hour, 2 extracting solution are merged and stands, obtain extracting solution 2, medicinal residues are standby；
4th step, will add the water of 5～8 times amount of medicinal residues weight in the medicinal residues of step (3), heating and refluxing extraction 2 times, each 2 little
Time, 2 extracting solution are merged and stands, obtain extracting solution 3；
5th step, merges extracting solution 1, extracting solution 2 and extracting solution 3, and when concentrating under reduced pressure obtains 80 DEG C, relative density is the filter of 1.35
Liquid, reclaims ethanol, and by gained filtrate adjustment proportion to when 80 DEG C 1.06, reduce pressure to obtain extractum, glycerol adding furnishing ointment.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393911A (en) * | 2013-07-27 | 2013-11-20 | 王树庆 | Drug for treating beriberi |
| CN104958546A (en) * | 2015-06-25 | 2015-10-07 | 庞艳杰 | Traditional Chinese medicine for treating damp-heat depressive-poison type cervical cancer and preparation method |
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2016
- 2016-06-02 CN CN201610384920.7A patent/CN105998644A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393911A (en) * | 2013-07-27 | 2013-11-20 | 王树庆 | Drug for treating beriberi |
| CN104958546A (en) * | 2015-06-25 | 2015-10-07 | 庞艳杰 | Traditional Chinese medicine for treating damp-heat depressive-poison type cervical cancer and preparation method |
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