CN105998634A - Honeyed pill recipe and identifying method thereof - Google Patents

Honeyed pill recipe and identifying method thereof Download PDF

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Publication number
CN105998634A
CN105998634A CN201610589307.9A CN201610589307A CN105998634A CN 105998634 A CN105998634 A CN 105998634A CN 201610589307 A CN201610589307 A CN 201610589307A CN 105998634 A CN105998634 A CN 105998634A
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percent
fructus
solution
honeyed pill
medicinal material
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陶淑霞
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Mongolian Medical Hospital of Fuxin Mongolian Autonomous County
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Fuxin Liaoning Mongolian Medicine Research Institute
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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Abstract

The invention relates to a honeyed pill recipe, which comprises the following ingredients: 2.14 percent of ginseng, 2.86 percent of fruit of Chinese wolfberry, 2.14 percent of poria cocos, 2.14 percent of radix angelicae sinensis, 2.14 percent of chrysanthemum flowers, 2.14 percent of chaff flower roots, 2.14 percent of pale butterflybush flowers, 0.46 percent of sheep's horns, 2.86 percent of seeds of Chinese dodder, 2.14 percent of tribulus terrester, 2.86 percent of motherwort fruit, 2.14 percent of cassia seeds, 2.14 percent of semen plantaginis, 2.86 percent of fruit of Chinese magnoliavine, 2.86 percent of szechwan Chinaberry fruit, 1.84 percent of rhizoma ligustici wallichii, 2.86 percent of concha haliotidis, 2.86 percent of safflowers, 2.14 percent of pipewort, 2.14 percent of small fennels, 2.14 percent of chingma abutilon seeds, 2.14 percent of liquorice roots, 2.86 percent of dwarf lilyturf roots and 47 percent of refined honey. Honeyed pills are prepared from pure traditional Chinese medicine; no any additive exists; all medicine ingredients used in the recipe have a good treatment effect; no side effect exists among the medicine; the preparation method is simple; the cost is low; the use is convenient; the treatment effect is good. The honeyed pills are mainly used for clearing away blood heat, clearing liver and improving vision; various eye diseases caused by blood heat and liver fire can be effectively treated; an identifying method of the honeyed pills is favorable for honeyed pill quality control; the safety and the reliability of the honeyed pills are improved.

Description

The formula of a kind of honeyed pill and discrimination method thereof
Technical field
The present invention relates to pharmaceutical technology field, the formula of a kind of honeyed pill and discrimination method thereof.
Background technology
Eyes are a kind of visual organ of people, are organs the finest, can be changed the concrete form of oneself in different environments, The mankind are made to obtain correct information in complex environment.Eyes are the very important a kind of sensory organ of the mankind, and the existence of ophthalmic can be to people's Daily life causes certain inconvenience, if medication or seek medical advice not in time, results even in blind, has many medicines treating ophthalmic on the market, But there will be dizzy dizzy, deficiency of QI with disinclination to talk, lassitude, distension and fullness in the abdomen, spontaneous sweating, insomnia and dreamful sleep, five heart heatings etc. after these drug administrations Symptom, and how to detect the quality controlling made medicine, is also the problem that always solving of pharmaceuticals industry.
Summary of the invention
For solving an above existing difficult problem, the invention discloses formula and the discrimination method thereof of a kind of honeyed pill.
A kind of formula of honeyed pill, described formula is: Radix Ginseng 2.14%, Fructus Lycii 2.86%, Poria 2.14%, Radix Angelicae Sinensis 2.14%, Flos Chrysanthemi 2.14%, Radix Achyranthis Bidentatae 2.14%, Flos Buddlejae 2.14%, Cornu Saigae Tataricae 0.46%, Semen Cuscutae 2.86%, Fructus Tribuli 2.14%, Fructus Leonuri 2.86%, Semen Cassiae 2.14%, car Front sub 2.14%, Fructus Schisandrae Chinensis 2.86%, Fructus Toosendan 2.86%, Rhizoma Chuanxiong 1.84%, Concha Haliotidis 2.86%, Flos Carthami 2.86%, Flos Eriocauli 2.14%, Fructus Foeniculi Perfume 2.14%, Semen Abutili 2.14%, Radix Glycyrrhizae 2.14%, Radix Ophiopogonis 2.86% and refined honey 47%.
The discrimination method of a kind of honeyed pill, it is characterised in that described discrimination method comprises the following steps:
A, taking this product 5g, add water 50ml, heated and boiled 15 minutes, lets cool, and filters, and filtrate is extracted with the shaking of ethyl acetate 15ml, carries Take liquid and be concentrated into 1ml, as need testing solution；
B, separately take Fructus Lycii control medicinal material 0.5g, be made in the same way of control medicinal material solution；
C, photograph thin layer chromatography (one annex VIB of China's coastal port) test, draw each 5ul of above two solution, respectively point On same silica gel g thin-layer plate, with ethyl acetate-chloroform-formic acid (3: 2: 1) as developing solvent, launch, take out, dry, put ultraviolet Inspect under light modulation (365nm)；
In d, test sample chromatograph, on position corresponding with control medicinal material chromatograph, the fluorescence speckle of aobvious same color.
Described discrimination method comprises the following steps:
A, taking this product 5g, add chloroform 20ml, be heated to reflux 30 minutes, filter, be evaporated filtrate, remaining residue adds three chloromethanes Alkane 1ml makes it dissolve, as need testing solution；
B, separately take Fructus Schisandrae Chinensis control medicinal material 1g, be made in the same way of control medicinal material solution；
C, photograph thin layer chromatography (one annex VIB of China's coastal port) test, draw each 2ul of above two solution, respectively point On same silica GF254 lamellae, with the upper solution of petroleum ether (30～60 DEG C)-Ethyl formate-formic acid (15: 5: 1) as developing solvent, Launch, take out, dry, put and inspect under ultra-violet lamp (254nm)；
In d, test sample chromatograph, on position corresponding with control medicinal material chromatograph, the speckle of aobvious same color.
Described discrimination method is: take this product, puts basis of microscopic observation: irregular branched agglomerate is colourless, meets chloral hydrate solution and dissolves；Mycelia without Color or light brown, diameter 4～6um.How cataclasm stellate hair is, complete person's body 2 cell, and base portion is arranged side by side, and every cell divides two forks, and tip is tapering or becomes Hook-shaped.Seed coat epidermis stone cell surface is seen in polygon and long polygon, and cell includes dark-brown thing.Pollen grain similar round or ellipse, diameter 43～66um, outer wall has short thorn and point-like engraving, has 3 germinal aperatures.Around fibre bundle, parenchyma cell contains prism of calcium oxalate, forms crystalline cellulose.
Beneficial effect: the honeyed pill of the present invention uses pure Chinese medicine to produce, and does not has any additive, and the ingredient used in formula all has well to be controlled Therapeutic effect, and be free from side effects between medicine, manufacture method is simple, low cost, and therapeutic effect easy to use is good, and the honeyed pill of the present invention is mainly used In clearing away heat from blood, liver heat removing and eyesight improving, can effectively treat heat in blood and various oculopathy that liver-fire causes, the discrimination method of honeyed pill contributes to the quality control of honeyed pill System, improves the safety and reliability of honeyed pill.
Detailed description of the invention
In conjunction with the embodiments, the present invention is described in further details.
Embodiment one:
A kind of formula of honeyed pill, described formula is: Radix Ginseng 2.14%, Fructus Lycii 2.86%, Poria 2.14%, Radix Angelicae Sinensis 2.14%, Flos Chrysanthemi 2.14%, Radix Achyranthis Bidentatae 2.14%, Flos Buddlejae 2.14%, Cornu Saigae Tataricae 0.46%, Semen Cuscutae 2.86%, Fructus Tribuli 2.14%, Fructus Leonuri 2.86%, Semen Cassiae 2.14%, car Front sub 2.14%, Fructus Schisandrae Chinensis 2.86%, Fructus Toosendan 2.86%, Rhizoma Chuanxiong 1.84%, Concha Haliotidis 2.86%, Flos Carthami 2.86%, Flos Eriocauli 2.14%, Fructus Foeniculi Perfume 2.14%, Semen Abutili 2.14%, Radix Glycyrrhizae 2.14%, Radix Ophiopogonis 2.86% and refined honey 47%.
By Radix Ginseng, Fructus Lycii, Poria, Radix Angelicae Sinensis, Flos Chrysanthemi, Radix Achyranthis Bidentatae, Flos Buddlejae, Cornu Saigae Tataricae, Semen Cuscutae, Fructus Tribuli, Fructus Leonuri, Semen Cassiae, car Front son, Fructus Schisandrae Chinensis, Fructus Toosendan, Rhizoma Chuanxiong, Concha Haliotidis, Flos Carthami, Flos Eriocauli, Fructus Foeniculi, Semen Abutili, Radix Glycyrrhizae and Radix Ophiopogonis powder are broken into fine powder, carry out Sieve, be mixed, be subsequently adding refined honey, make big honeyed pills, Cinnabaris coating, to obtain final product.
Discrimination method comprises the following steps:
A, taking this product 5g, add water 50ml, heated and boiled 15 minutes, lets cool, and filters, and filtrate is extracted with the shaking of ethyl acetate 15ml, and extracting solution concentrates To 1ml, as need testing solution；
B, separately take Fructus Lycii control medicinal material 0.5g, be made in the same way of control medicinal material solution；
C, photograph thin layer chromatography (one annex VIB of China's coastal port) test, draw each 5ul of above two solution, put respectively in same silica gel On G lamellae, with ethyl acetate-chloroform-formic acid (3: 2: 1) as developing solvent, launch, take out, dry, put under ultra-violet lamp (365nm) Inspect；
In d, test sample chromatograph, on position corresponding with control medicinal material chromatograph, the fluorescence speckle of aobvious same color.
Embodiment two:
A kind of formula of honeyed pill, described formula is: Radix Ginseng 2.14%, Fructus Lycii 2.86%, Poria 2.14%, Radix Angelicae Sinensis 2.14%, Flos Chrysanthemi 2.14%, Radix Achyranthis Bidentatae 2.14%, Flos Buddlejae 2.14%, Cornu Saigae Tataricae 0.46%, Semen Cuscutae 2.86%, Fructus Tribuli 2.14%, Fructus Leonuri 2.86%, Semen Cassiae 2.14%, car Front sub 2.14%, Fructus Schisandrae Chinensis 2.86%, Fructus Toosendan 2.86%, Rhizoma Chuanxiong 1.84%, Concha Haliotidis 2.86%, Flos Carthami 2.86%, Flos Eriocauli 2.14%, Fructus Foeniculi Perfume 2.14%, Semen Abutili 2.14%, Radix Glycyrrhizae 2.14%, Radix Ophiopogonis 2.86% and refined honey 47%.
By Radix Ginseng, Fructus Lycii, Poria, Radix Angelicae Sinensis, Flos Chrysanthemi, Radix Achyranthis Bidentatae, Flos Buddlejae, Cornu Saigae Tataricae, Semen Cuscutae, Fructus Tribuli, Fructus Leonuri, Semen Cassiae, car Front son, Fructus Schisandrae Chinensis, Fructus Toosendan, Rhizoma Chuanxiong, Concha Haliotidis, Flos Carthami, Flos Eriocauli, Fructus Foeniculi, Semen Abutili, Radix Glycyrrhizae and Radix Ophiopogonis powder are broken into fine powder, carry out Sieve, be mixed, be subsequently adding refined honey, make big honeyed pills, Cinnabaris coating, to obtain final product.
Discrimination method comprises the following steps:
A, taking this product 5g, add chloroform 20ml, be heated to reflux 30 minutes, filter, be evaporated filtrate, remaining residue makes it plus chloroform 1ml Dissolve, as need testing solution；
B, separately take Fructus Schisandrae Chinensis control medicinal material 1g, be made in the same way of control medicinal material solution；
C, photograph thin layer chromatography (one annex VIB of China's coastal port) test, draw each 2ul of above two solution, put respectively in same silica gel On GF254 lamellae, with the upper solution of petroleum ether (30～60 DEG C)-Ethyl formate-formic acid (15: 5: 1) as developing solvent, launch, take out, dry in the air Dry, put and inspect under ultra-violet lamp (254nm)；
In d, test sample chromatograph, on position corresponding with control medicinal material chromatograph, the speckle of aobvious same color.
Embodiment three:
A kind of formula of honeyed pill, described formula is: Radix Ginseng 2.14%, Fructus Lycii 2.86%, Poria 2.14%, Radix Angelicae Sinensis 2.14%, Flos Chrysanthemi 2.14%, Radix Achyranthis Bidentatae 2.14%, Flos Buddlejae 2.14%, Cornu Saigae Tataricae 0.46%, Semen Cuscutae 2.86%, Fructus Tribuli 2.14%, Fructus Leonuri 2.86%, Semen Cassiae 2.14%, car Front sub 2.14%, Fructus Schisandrae Chinensis 2.86%, Fructus Toosendan 2.86%, Rhizoma Chuanxiong 1.84%, Concha Haliotidis 2.86%, Flos Carthami 2.86%, Flos Eriocauli 2.14%, Fructus Foeniculi Perfume 2.14%, Semen Abutili 2.14%, Radix Glycyrrhizae 2.14%, Radix Ophiopogonis 2.86% and refined honey 47%.
By Radix Ginseng, Fructus Lycii, Poria, Radix Angelicae Sinensis, Flos Chrysanthemi, Radix Achyranthis Bidentatae, Flos Buddlejae, Cornu Saigae Tataricae, Semen Cuscutae, Fructus Tribuli, Fructus Leonuri, Semen Cassiae, car Front son, Fructus Schisandrae Chinensis, Fructus Toosendan, Rhizoma Chuanxiong, Concha Haliotidis, Flos Carthami, Flos Eriocauli, Fructus Foeniculi, Semen Abutili, Radix Glycyrrhizae and Radix Ophiopogonis powder are broken into fine powder, carry out Sieve, be mixed, be subsequently adding refined honey, make big honeyed pills, Cinnabaris coating, to obtain final product.
Discrimination method is: take this product, puts basis of microscopic observation: irregular branched agglomerate is colourless, meets chloral hydrate solution and dissolves；Hyphae colorless or light brown Color, diameter 4～6um.How cataclasm stellate hair is, complete person's body 2 cell, and base portion is arranged side by side, and every cell divides two forks, and tip is tapering or becomes hook-shaped.Plant epidermis Skin stone cell surface is seen in polygon and long polygon, and cell includes dark-brown thing.Pollen grain similar round or ellipse, diameter 43～66um, outer wall tool is short Thorn and point-like are carved, and have 3 germinal aperatures.Around fibre bundle, parenchyma cell contains prism of calcium oxalate, forms crystalline cellulose.
The character of honeyed pill of the present invention: this product is bolarious big honeyed pills, section brown；Color is fragrant, sweet in the mouth.
Honeyed pill function of the present invention cures mainly: clearing away heat from blood, liver heat removing and eyesight improving.The various oculopathy caused for heat in blood and flaming up of liver-fire.
The usage and dosage of honeyed pill of the present invention: oral.It is grown up 1 ball, 1～2 time on the one；Or follow the doctor's advice.
The points for attention of honeyed pill of the present invention: be not taken by pregnant women.Platycoria person be cautious use of；Hepatic and kidney function obstacle person disables；This product should not take for a long time.
The storage of honeyed pill of the present invention: seal, the dry place of Zhiyin airing.
The packaging of honeyed pill of the present invention: polrvinyl chloride solid medicinal stiff sheet, drug packaging aluminium foil.

Claims (4)

1. the formula of a honeyed pill, it is characterized in that, described formula is: Radix Ginseng 2.14%, Fructus Lycii 2.86%, Poria 2.14%, Radix Angelicae Sinensis 2.14%, Flos Chrysanthemi 2.14%, Radix Achyranthis Bidentatae 2.14%, Flos Buddlejae 2.14%, Cornu Saigae Tataricae 0.46%, Semen Cuscutae 2.86%, Fructus Tribuli 2.14%, Fructus Leonuri 2.86%, Semen Cassiae 2.14%, Semen Plantaginis 2.14%, Fructus Schisandrae Chinensis 2.86%, Fructus Toosendan 2.86%, Rhizoma Chuanxiong 1.84%, Concha Haliotidis 2.86%, Flos Carthami 2.86%, Flos Eriocauli 2.14%, Fructus Foeniculi 2.14%, Semen Abutili 2.14%, Radix Glycyrrhizae 2.14%, Radix Ophiopogonis 2.86% and refined honey 47%.
2. the discrimination method of a honeyed pill, it is characterised in that described discrimination method comprises the following steps:
A, taking this product 5g, add water 50ml, heated and boiled 15 minutes, lets cool, and filters, and filtrate is extracted with the shaking of ethyl acetate 15ml, and extracting solution is concentrated into 1ml, as need testing solution；
B, separately take Fructus Lycii control medicinal material 0.5g, be made in the same way of control medicinal material solution；
C, photograph thin layer chromatography (one annex VIB of China's coastal port) test, draw each 5ul of above two solution, put respectively on same silica gel g thin-layer plate, with ethyl acetate-chloroform-formic acid (3: 2: 1) as developing solvent, launch, take out, dry, put and inspect under ultra-violet lamp (365nm)；
In d, test sample chromatograph, on position corresponding with control medicinal material chromatograph, the fluorescence speckle of aobvious same color.
The discrimination method of a kind of honeyed pill the most according to claim 2, it is characterised in that described discrimination method comprises the following steps:
A, taking this product 5g, add chloroform 20ml, be heated to reflux 30 minutes, filter, be evaporated filtrate, remaining residue makes it dissolve, as need testing solution plus chloroform 1ml；
B, separately take Fructus Schisandrae Chinensis control medicinal material 1g, be made in the same way of control medicinal material solution；
C, photograph thin layer chromatography (one annex VIB of China's coastal port) test, draw each 2ul of above two solution, put respectively on same silica GF254 lamellae, with the upper solution of petroleum ether (30～60 DEG C)-Ethyl formate-formic acid (15: 5: 1) as developing solvent, launch, take out, dry, put and inspect under ultra-violet lamp (254nm)；
In d, test sample chromatograph, on position corresponding with control medicinal material chromatograph, the speckle of aobvious same color.
The discrimination method of a kind of honeyed pill the most according to claim 2, it is characterised in that described discrimination method is: take this product, puts basis of microscopic observation: irregular branched agglomerate is colourless, meets chloral hydrate solution and dissolves；Hyphae colorless or light brown, diameter 4～6um.How cataclasm stellate hair is, complete person's body 2 cell, and base portion is arranged side by side, and every cell divides two forks, and tip is tapering or becomes hook-shaped.Seed coat epidermis stone cell surface is seen in polygon and long polygon, and cell includes dark-brown thing.Pollen grain similar round or ellipse, diameter 43～66um, outer wall has short thorn and point-like engraving, has 3 germinal aperatures.Around fibre bundle, parenchyma cell contains prism of calcium oxalate, forms crystalline cellulose.
CN201610589307.9A 2016-07-25 2016-07-25 Honeyed pill recipe and identifying method thereof Pending CN105998634A (en)

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CN113694135A (en) * 2020-05-19 2021-11-26 阜新蒙古族自治县蒙医医院 Traditional Chinese medicine composition for preventing and treating eye diseases, traditional Chinese medicine honeyed pills and preparation method thereof
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CN113694135A (en) * 2020-05-19 2021-11-26 阜新蒙古族自治县蒙医医院 Traditional Chinese medicine composition for preventing and treating eye diseases, traditional Chinese medicine honeyed pills and preparation method thereof
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