CN104706771A - Composition with anti-anoxia and acute high-altitude reaction prevention and treatment effects - Google Patents
Composition with anti-anoxia and acute high-altitude reaction prevention and treatment effects Download PDFInfo
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Abstract
The invention discloses a composition with anti-anoxia and acute high-altitude reaction prevention and treatment effects. The composition is prepared from the following raw materials in parts by weight: 3 to 18 parts of platycodon grandiflorum, 2 to 20 parts of poria cocos, 3 to 12 parts of ligusticum wallichii, 3 to 12 parts of radix angelicae, 5 to 16 parts of uncaria tomentosa and 5 to 20 parts of caulis polygoni multiflori. The composition is prepared into tablets, granules, powder, pills, teabags, capsules, decoction, oral liquid, dripping pills or syrup by adopting a conventional pharmaceutical method in pharmacy, has good anti-anoxia and acute high-altitude reaction prevention and treatment effects as proved by an animal experiment, and can be used for preparing medicaments or health products with anti-anoxia and acute high-altitude reaction prevention and treatment effects.
Description
Technical field
The present invention relates to Chinese medicine and natural medicine field, particularly relate to a kind of pharmaceutical composition with control acute high altitude reaction and resisting oxygen lack.
Background technology
Acute high altitude reaction is the clinical syndrome occurred because high altitude anoxia causes somatic damage, is a kind of modal acute high altitude sickness.Clinical symptoms shows as headache, dizziness, nervous, uncomfortable in chest, Nausea and vomiting, weak, poor appetite, sleep disorder, brothers are numb, can edema etc. be there is in face and extremity, as can not get properly treating process, plateau pneumochysis and high altitude cerebral adema etc. can be developed into, entail dangers to is to the life security of sufferer, and prevention and the treatment of acute high altitude sickness are one of the difficult point in current medical field.Special effectively preventing medicine is there is no at present on the market for acute high altitude reaction.Application Rhodiola rosea capsules control acute high altitude reaction, the process of taking reaches one week, and effect is slow and unstable, clinical response unsatisfactory curative effect, especially unsatisfactory to clinical headache, dizziness, the symptom effect such as uncomfortable in chest.Current, China goes to that travel in highlands, the people of Working Life reaches 20,000,000 more than every year, and with annual 15% speed increment, develop medicine, the health product with resisting oxygen lack and there is wide market prospect and good social benefit.
Summary of the invention
For the deficiency of the above technology, goal of the invention of the present invention is the oxygen lack resistance composition and the application thereof that provide a kind of altitude sickness prevention.Said composition can alleviate the symptoms such as headache that altitude sickness disease causes, dizziness, nervous, uncomfortable in chest, Nausea and vomiting, weak, poor appetite, Be very effective.
Goal of the invention of the present invention is achieved by the following technical solution:
A kind of compositions of preventing and treating acute high altitude reaction and anoxia enduring, said composition contains Chinese medicine extract, by weight, described Chinese medicine extract is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Radix Platycodonis 3 ~ 18 parts, 2 ~ 20 parts, Poria, Rhizoma Chuanxiong 3 ~ 12 parts, the Radix Angelicae Dahuricae 3 ~ 12 parts, Ramulus Uncariae Cum Uncis 5 ~ 16 parts, Caulis Polygoni Multiflori 5 ~ 20 parts, and acceptable adjuvant or complementary composition on medicament or food.
Preferably, for preventing and treating in the compositions of acute high altitude reaction and anoxia enduring, by weight, described Chinese medicine extract is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Radix Platycodonis 4 ~ 6 parts, 4 ~ 6 parts, Poria, Rhizoma Chuanxiong 3 ~ 5 parts, the Radix Angelicae Dahuricae 3 ~ 5 parts, Ramulus Uncariae Cum Uncis 6 ~ 8 parts, acceptable adjuvant or complementary composition on Caulis Polygoni Multiflori 9 ~ 11 parts and medicament or food.
Preferably, for preventing and treating in the compositions of acute high altitude reaction and anoxia enduring, by weight, described Chinese medicine extract is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Radix Platycodonis 5 parts, 5 parts, Poria, Rhizoma Chuanxiong 3 parts, the Radix Angelicae Dahuricae 3 parts, Ramulus Uncariae Cum Uncis 7 parts, acceptable adjuvant or complementary composition on Caulis Polygoni Multiflori 10 parts and medicament or food.
Preferably, for preventing and treating in the compositions of acute high altitude reaction and anoxia enduring, described medicine is oral formulations.
Preferably, for preventing and treating in the medicine of acute high altitude reaction and anoxia enduring, described oral formulations is tablet, capsule, pill, granule, decoction, oral solutions, drop pill or syrup.
It should be noted that, traditional Chinese medicinal material raw materials of the present invention has following source: samphire Rhizoma Chuanxiong selected by Rhizoma Chuanxiong
ligusticum chuangxionghort. dry rhizome.The Radix Angelicae Dahuricae selects the umbellifer Radix Angelicae Dahuricae
angelica dahurica(Fsch.ex Hoffm.) Benth.et Hook.f. or Radix angelicae dahuricae
angelica dahurica(Fsch.ex Hoffm.) Benth.et Hook.f.var.
formosana(Boiss.) Shan etYuan dry root.Campanulaceae Radix Platycodonis selected by Radix Platycodonis
platycodon grandiflorum(Jacq.) dry root of A .DC..On Polyporaceae Poria selected by Poria
poria cocos(Schw.) dry sclerotia of Wolf.Caulis Polygoni Multiflori selects polygonum multiflorum thunb
polygonum multiflorumthunb. dry rattan.Maguireothamnus speciosus Ramulus Uncariae Cum Uncis selected by Ramulus Uncariae Cum Uncis
uncaria rhynchophylla(Miq.) Jachs., Ramulus Uncariae macrophyllae
uncaria macrophyllawall. Ramulus Uncariae Cum Uncis
uncaria hirsutahavil., Uncaria sinensis (Oliv.) Havil.
uncaria sinensis(Oliv.) Havil. or stockless fruit Ramulus Uncariae Cum Uncis
uncaria sessilifructusroxb. dry stem and branch with belt hook.
The Chinese medicine extract that the present invention relates to is prepared as follows and obtains, and comprises three kinds:
(1) by weight taking Radix Platycodonis 3 ~ 18 parts respectively, 2 ~ 20 parts, Poria, Rhizoma Chuanxiong 3 ~ 12 parts, the Radix Angelicae Dahuricae 3 ~ 12 parts, Ramulus Uncariae Cum Uncis 5 ~ 16 parts, Caulis Polygoni Multiflori 5 ~ 20 parts, and be ground into coarse powder, get the Radix Platycodonis of the amount of taking, Poria, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Ramulus Uncariae Cum Uncis, Caulis Polygoni Multiflori coarse powder, by 60-95% alcohols soak extraction or heating extraction, extracting liquid filtering, is condensed into extractum, adds acceptable adjuvant or complementary composition on medicament or food and is prepared from preparation.
(2) by weight taking Radix Platycodonis 3 ~ 18 parts respectively, 2 ~ 20 parts, Poria, Rhizoma Chuanxiong 3 ~ 12 parts, the Radix Angelicae Dahuricae 3 ~ 12 parts, Ramulus Uncariae Cum Uncis 5 ~ 16 parts, Caulis Polygoni Multiflori 5 ~ 20 parts, and be ground into coarse powder, get the Radix Platycodonis of the amount of taking, Poria, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Ramulus Uncariae Cum Uncis, Caulis Polygoni Multiflori coarse powder, by 60-95% alcohols soak extraction or heating extraction, extracting liquid filtering, be condensed into extractum, with n-butanol extraction after extractum use water suspendible, reclaim butanol extraction liquid and obtain extractum, add acceptable adjuvant or complementary composition on medicament or food and be prepared from preparation.
(3) by weight taking Radix Platycodonis 3 ~ 18 parts respectively, 2 ~ 20 parts, Poria, Rhizoma Chuanxiong 3 ~ 12 parts, the Radix Angelicae Dahuricae 3 ~ 12 parts, Ramulus Uncariae Cum Uncis 5 ~ 16 parts, Caulis Polygoni Multiflori 5 ~ 20 parts, and be ground into coarse powder, get the Radix Platycodonis of the amount of taking, Poria, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Ramulus Uncariae Cum Uncis, Caulis Polygoni Multiflori coarse powder, by 60-95% alcohols soak extraction or heating extraction, extracting liquid filtering, be condensed into extractum, be extracted with ethyl acetate after extractum water suspendible, reclaim acetic acid ethyl acetate extract and obtain extractum, add acceptable adjuvant or complementary composition on medicament or food and be prepared from preparation.
On described medicament or food, acceptable adjuvant or complementary composition are any one or two kinds of and the above compositions in glucose, starch, dextrin, micropowder silica gel and magnesium stearate.
The pharmaceutical preparation that the present invention relates to can obtain according to general preparation method, and the preparation method of such as granule can be, after taking above-mentioned Chinese medicine extract, adds the cane sugar powder of 8 times amount, dry granulation, and packaging, often wraps 5g.2-4 hour before entering plateau starts to take this granule, every day 3 times, each 1 bag.
Acute high altitude sickness morbidity Common Mechanism is mainly anoxia-induced apoptosis, oxygen deprivation stress, Water-Electrolyte retention disorder, inflammatory reaction syndrome.Inventor is found by the experimental study of mice airtight anoxia, above-mentioned Chinese medicine extract can extend the time-to-live of mice under airtight anoxia condition and total oxygen consumption, and rat 8 hours urine volume can be increased, reduce cerebrospinal pressure, effectively can solve water, electrolyte retention is disorderly.Therefore another object of the present invention is to provide a kind of pharmaceutical applications, that is: above-mentioned Chinese medicine extract is preparing the application in the medicine of anoxia enduring, health product and food.
Compositions of the present invention effectively can alleviate headache that altitude sickness disease causes, loss of appetite, asthenia, the symptom such as weak, dizzy, is clinical prevention treatment altitude sickness disease, alleviates individual various symptom that altitude sickness causes and provides a kind of new selection.
Detailed description of the invention
The present invention is described in further detail below, and to make those skilled in the art can implement according to this with reference to description word, but protection scope of the present invention is not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
The preparation of Chinese medicine granules
Take Radix Platycodonis 0.50kg, Rhizoma Chuanxiong 0.40kg, Radix Angelicae Dahuricae 0.30kg, Ramulus Uncariae Cum Uncis 0.45kg, Caulis Polygoni Multiflori 0.60 and Poria 1.00kg merge, add 70% (v/v) alcohol reflux three times, first time adds 8 times amount that Extraction solvent is medical material weight, reflux, extract, 2h, for the second time, third time adds 6 times amount that Extraction solvent is medical material weight, each 1h, merge extractive liquid, extracting solution 0.08MPa, be evaporated at 70 DEG C without alcohol taste, add 95% (v/v) ethanol to stir, hold over night, filter, filtrate is at 0.08MPa, under 65 DEG C of conditions, concentrating under reduced pressure becomes thick paste, add the cane sugar powder of 8 times amount, stir evenly, make granule, packaging after dry, obtain.
Embodiment 2
Chinese medicinal tablet
Take Radix Platycodonis 0.52kg, Rhizoma Chuanxiong 0.45kg, Radix Angelicae Dahuricae 0.30kg, Ramulus Uncariae Cum Uncis 0.48kg, Caulis Polygoni Multiflori 0.65kg and Poria 1.00kg merges, add 70% (v/v) alcohol reflux three times, first time adds 8 times amount that Extraction solvent is medical material weight, reflux, extract, 2h, for the second time, third time adds 6 times amount that Extraction solvent is medical material weight, each 1h, merge extractive liquid, extracting solution 0.08MPa, be evaporated at 70 DEG C without alcohol taste, add up medical material weight 0.5 times of water gaging suspendible, add n-butanol extraction twice, first time adds 0.8 times amount that n-butyl alcohol is water, second time adds 0.6 times amount that n-butyl alcohol is water, merge butanol extraction liquid, extract is at 0.08MPa, under 82 DEG C of conditions, concentrating under reduced pressure becomes thick paste, add starch and microcrystalline Cellulose, mixing, make granule, tabletted after dry, obtain.
Embodiment 3
Chinese medicine capsules
Take Radix Platycodonis 0.55kg, Rhizoma Chuanxiong 0.48kg, Radix Angelicae Dahuricae 0.35kg, Ramulus Uncariae Cum Uncis 0.45kg, Caulis Polygoni Multiflori 0.66kg and Poria 1.08kg merges, add 70% (v/v) alcohol reflux three times, first time adds 8 times amount that Extraction solvent is medical material weight, reflux, extract, 2h, for the second time, third time adds 6 times amount that Extraction solvent is medical material weight, each 1h, merge extractive liquid, extracting solution 0.08MPa, be evaporated at 70 DEG C without alcohol taste, add up medical material weight 0.5 times of water gaging suspendible, add extraction into ethyl acetate twice, first time adds 0.8 times amount that ethyl acetate is water, second time adds 0.6 times amount that ethyl acetate is water, combined ethyl acetate extract, extract is at 0.08MPa, under 65 DEG C of conditions, concentrating under reduced pressure becomes thick paste, add starch and microcrystalline Cellulose, mixing, make granule, incapsulate, obtain.
Embodiment 4
The animal experiment of Chinese medicine extract
(1), anoxia enduring experiment
1 experiment material
1.1 animal
SPF level Kunming mouse, male and female have both, and body weight is 18-22g, purchased from animal housing of West China Center of Medical Sciences of Sichuan University, the animal quality certification number: real dynamic No. 67th, the pipe in river.
Rearing conditions: after animal enters laboratory, separately, every cage puts 5 in a suitable place to breed to male and female, raises and enables after 3 days, by special messenger's feeding and management.Animal housing's illumination is sufficient, and heating ventilation and air-conditioning equipment is good, and room temperature controls at 20 DEG C ~ 25 DEG C, and humidity is 55% ~ 65%.Laboratory is regularly sterilized routinely.
1.2 medicine
Example 1 is prepared into granule of the present invention, every 1g granule powder is containing crude drug in whole 1.25g, clinical granule adult (70kg) consumption of the present invention is 18g, Mouse oral dose,equivalent is 18/70g/kg × 35/3 ≈ 3g/kg, according to adult's clinical oral administration dosage, empirically the body surface area conversion factor of animals and human beings converts the dose,equivalent of animal to, then get 0.5,1,2 times amount as 3 dosage of laboratory animal administration.In table 1, dosage calculates by every kg body weight dosage (g/kg), be respectively 1.5,3,6g/kg.
Example 2 is prepared into tablet of the present invention, clinical granule adult (70kg) consumption of the present invention is 6g, Mouse oral dose,equivalent is 18/70g/kg × 35/3 ≈ 1g/kg, according to adult's clinical oral administration dosage, empirically the body surface area conversion factor of animals and human beings converts the dose,equivalent of animal to, then get 0.5,1,2 times amount as 3 dosage of laboratory animal administration.In table 2, dosage calculates by every kg body weight dosage (g/kg), be respectively 0.5,1.0,2.0g/kg.
Rhodiola rosea capsules, 0.38g/ grain, is produced by Radix Rhodiolae development center, Tibet Military Area Command, authentication code: the accurate word of army's medicine: Z2006001, lot number: 130301.Using Rhodiola rosea capsules as positive control drug (0.38g/ grain); Adult's usage and dosage: oral, 2 tablets/time, 2 times/day.By body surface area conversion, the dose,equivalent of mice is 0.205 g/kg.
1.3 instruments and reagent
Wide mouthed bottle (125mL), stopwatch, vaseline, sodica calx, ether, Guangzhou Chemical Reagent Factory is produced.
2 methods and result
2.1 medicinal granules of the present invention are on the impact of normal mouse normobaric hypoxia
Choose healthy Kunming mouse 100, body weight 18-22g, male and female half and half, 5 groups are divided at random by body weight, sex, often organize 20, once, blank group gives normal saline to each treated animal gastric infusion every day, for three days on end, after last administration, 30min tests, and each group of mice is put into respectively the 125ml ground wide mouthed bottle (every bottle) filling 5g sodica calx, seals bottleneck with vaseline, cover tightly, make it air tight, immediately timing, with respiratory arrest position index, observe the time of mice death because of anoxia, the results are shown in Table 1.
Table 1 medicinal granule agent of the present invention is on the impact (x ± s, n=20) of normal mouse normobaric hypoxia
| Group | Dosage (g/kg) | Time-to-live (s) |
| Compositions low dose group | 1.50 | 810.45±83.12 **# |
| Dosage group in compositions | 3.00 | 896.35±93.30 **## |
| Compositions high dose group | 6.00 | 923.80±95.68 **## |
| Rhodiola rosea capsules group | 0.205 | 795.55±86.25 * |
| Blank group | - | 729.60±85.36 |
Note: compare with blank group,
*p<0.05,
*p<0.01; Compare with Radix Rhodiolae group,
#p<0.05,
##p<0.01.
2.2 Tablets to be dehisced the impact of breathing time on mice broken end
Choose healthy Kunming mouse 100, body weight 18-22g, male and female half and half, be divided into 5 groups at random by body weight, sex, often organize 20, once, blank group gives normal saline to each treated animal gastric infusion every day, for three days on end, 1h after last administration, by mice by only breaking end; Breathing dwell time as anoxia enduring index by after stopwatch record mice broken end to dehiscing immediately, the results are shown in Table 2.
Table 2 Tablets to be dehisced the impact (x ± s, n=20) of breathing time on mice broken end
| Group | Dosage (g/kg) | Mouth breathing time (s) |
| Compositions low dose group | 0.5 | 22.45±3.12 * |
| Dosage group in compositions | 1.0 | 24.39±3.30 **# |
| Compositions high dose group | 2.0 | 25.90±4.68 **## |
| Rhodiola rosea capsules group | 0.205 | 22.65±3.25 * |
| Blank group | - | 17.96±3.36 |
Note: compare with blank group,
*p<0.05,
*p<0.01; Compare with Radix Rhodiolae group,
#p<0.05,
##p<0.01.
(2), water-electrolyte metabolism
1 capsule of the present invention is on the impact of cerebrospinal fluid of rats pressure
1.1 laboratory animals and grouping
Get cleaning grade SD rat 100, male and female half and half, weight 180 ~ 210g, purchased from Third Military Medical University's Experimental Animal Center [license disease number: SYXK(change) 2012-0002], random packet is numbered, and is equally divided into five groups: Plain matched group, plateau matched group, compositions high, medium and low (0.22,0.44,0.88g/kg) three dosage groups.Plain matched group be laboratory animal in capacity distilled water groups such as Plain gavage, all the other each group all enters (height above sea level 5000m) in simulated high altitude low-pressure oxygen cabin.The capacity distilled water groups such as plateau matched group only gavages, composition capsule three dosage component do not gavage medicine by 1ml/100g.
1.2 instruments and reagent
RM6240B/C System of organism signal-2.0s version software, YPJ01 pressure transducer (Chengdu Instruement Factory), STRONG 90 high speed rotating skull rig (Shenzhen Rui Wode Life Science company limited), brain solid positioner (ST-SWD-B) low-pressure oxygen cabin (Guizhou wind and thunder), RM6240BD multi-path physiology signal acquiring processing system (Chengdu Instruement Factory).
1.3 medicine and reagent
Embodiment 3 is prepared into capsule of the present invention, 20% Ethylurethanm, 1% hydrogenperoxide steam generator and normal saline.Adult's oral dose every day is 5g, Oral Administration in Rats dose,equivalent is 6/70g/kg × 6.1 ≈ 0.44g/kg, according to adult's clinical oral administration dosage, empirically the body surface area conversion factor of animals and human beings converts the dose,equivalent of animal to, then get 0.5,1,2 times amount as 3 dosage of laboratory animal administration.。In table, dosage calculates by every kg body weight dosage (g/kg), be respectively 0.22,0.44,0.88g/kg.
1.4 method
Except the matched group of Plain, all the other rats all enter in simulated high altitude low-pressure oxygen cabin (height above sea level 5000m).After free diet 12h, except plateau matched group gavages isopyknic distilled water, all the other are respectively organized gavage respectively and give various dose compositions.After administration 2h, sugar juice (1.2g/100g) intraperitoneal injection of anesthesia animal is drawn with 20% crow, cut off head hair, use iodophor disinfection skin of head, cut off the skin of head of about 1cm ~ 1.5cm again, peel off skull fascia, make to expose bregma and select (bandit's shape seam and sagittal suture cross point) and rear halogen point (lambdoid suture and sagittal suture cross point), smear sutura with 1% hydrogenperoxide steam generator, make change clear.Be placed on brain solid positioner, fixedly make skull become a horizontal plane, with syringe needle location bregma point, move 1.1mm backward along sagittal suture, then move horizontally 1.5mm, labelling.Bore at gauge point high speed cranium and make a call to the aperture that a diameter is about 0.5mm, the probe being connected with pressure transducer is deep into tricorn intracavity (degree of depth is about 3.8mm ~ 4.3mm), the slow fine adjustment degree of depth, makes the obvious waveform of appearance, stablize 3min, read data.
1.5 statistical procedures
Adopt spss19.0 statistical analysis software to process, experimental data is taked
± s represents, compares and adopt t inspection between group, and multiple-group analysis meets homogeneity of variance and adopts one factor analysis of variance (one way ANOVN).Be that difference has statistical significance with P<0.05.
(2) result
Table 3 capsule of the present invention is on the impact of simulated high altitude anoxia 5000m environment cerebrospinal fluid of rats pressure
(
±s,n=20)
* * P<0.01 compared with the matched group of Plain; ## P<0.01, # P<0.05 compared with the matched group of plateau.
2, granule of the present invention is on the impact of hypobaric hypoxia rat urine volume.
2.1 laboratory animals and grouping
Get cleaning grade SD rat 100, male and female half and half, weight 180 ~ 210g, purchased from Third Military Medical University's Experimental Animal Center [license disease number: SYXK(change) 2012-0002], random packet is numbered, and is equally divided into five groups: Plain matched group, plateau matched group, compositions high, medium and low (0.78,1.57,3.14g/kg) three dosage groups.Plain matched group be laboratory animal in capacity distilled water groups such as Plain gavage, all the other each group all enters (height above sea level 5000m) in simulated high altitude low-pressure oxygen cabin.The capacity distilled water groups such as plateau matched group only gavages, compositions three dosage component do not gavage medicine by 1ml/100g.
2.2 instruments and reagent
Low-pressure oxygen cabin (Guizhou wind and thunder), pipet, rubber pipette bulb.
2.3 medicines and reagent
Embodiment 1 is prepared into granule of the present invention, 20% Ethylurethanm, 1% hydrogenperoxide steam generator and normal saline.Oral Administration in Rats dose,equivalent is 18/70g/kg × 6.1 ≈ 1.57g/kg, according to adult's clinical oral administration dosage, empirically the body surface area conversion factor of animals and human beings converts the dose,equivalent of animal to, then get 0.5,1,2 times amount as 3 dosage of laboratory animal administration.In table 4, dosage calculates by every kg body weight dosage (g/kg), be respectively 0.78,1.57,3.14g/kg.Rhodiola rosea capsules, 0.38g/ grain, is produced by Radix Rhodiolae development center, Tibet Military Area Command, authentication code: the accurate word of army's medicine: Z2006001, lot number: 130301.Using Rhodiola rosea capsules as positive control drug (0.38g/ grain); Adult's usage and dosage: oral, 2 tablets/time, 2 times/day.By body surface area conversion, the dose,equivalent of rat is 0.13 g/kg.
2.4 method
Except the matched group of Plain, all the other rats all enter in simulated high altitude low-pressure oxygen cabin (height above sea level 5000m).Each group all by after 20ml/kg body weight Water l oad 2h, drained of urine, then gavage relative medicine, puts rat in metabolic cage, free diet, collects urine in 8h.
(2) result
Table 4 present composition granule on the impact of hypobaric hypoxia rat urine volume (
± s, n=20)
Compared with the group of plateau, * * P < 0.01, * P < 0.05.
3, conclusion
From above pharmacological testing, present composition energy significant prolongation anoxia in mice death time and breathing time of dehiscing after breaking end, have good resisting oxygen lack, and reduce rat intracranial pressure and increase its urine volume, improve water and electrolyte metabolism disorder.Give full play to the advantage of compositions thing Mutiple Targets, multipath effect, thus reach the object of control acute high altitude reaction.
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the legend described.
Claims (6)
1. prevent and treat the compositions of acute high altitude reaction and anoxia enduring for one kind, said composition contains Chinese medicine extract, it is characterized in that: by weight, described Chinese medicine extract is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Radix Platycodonis 3 ~ 18 parts, 2 ~ 20 parts, Poria, Rhizoma Chuanxiong 3 ~ 12 parts, the Radix Angelicae Dahuricae 3 ~ 12 parts, Ramulus Uncariae Cum Uncis 5 ~ 16 parts, Caulis Polygoni Multiflori 5 ~ 20 parts.
2. a kind of compositions of preventing and treating acute high altitude reaction and anoxia enduring according to claim 1, it is characterized in that: by weight, described Chinese medicine extract is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Radix Platycodonis 4 ~ 6 parts, 4 ~ 6 parts, Poria, Rhizoma Chuanxiong 3 ~ 5 parts, the Radix Angelicae Dahuricae 3 ~ 5 parts, Ramulus Uncariae Cum Uncis 6 ~ 8 parts, Caulis Polygoni Multiflori 9 ~ 11 parts.
3. a kind of compositions of preventing and treating acute high altitude reaction and anoxia enduring according to claim 2, it is characterized in that: by weight, described Chinese medicine extract is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Radix Platycodonis 5 parts, 5 parts, Poria, Rhizoma Chuanxiong 3 parts, the Radix Angelicae Dahuricae 3 parts, Ramulus Uncariae Cum Uncis 7 parts, Caulis Polygoni Multiflori 10 parts.
4. a kind of preparation method of preventing and treating the oxygen lack resistance composition of altitude sickness according to any one of claim 1-3, is characterized in that: this preparation method described comprises following three kinds:
(1) by weight taking Radix Platycodonis 3 ~ 18 parts respectively, 2 ~ 20 parts, Poria, Rhizoma Chuanxiong 3 ~ 12 parts, the Radix Angelicae Dahuricae 3 ~ 12 parts, Ramulus Uncariae Cum Uncis 5 ~ 16 parts, Caulis Polygoni Multiflori 5 ~ 20 parts, and be ground into coarse powder, get the Radix Platycodonis of the amount of taking, Poria, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Ramulus Uncariae Cum Uncis, Caulis Polygoni Multiflori coarse powder, by 60-95% alcohols soak extraction or heating extraction, extracting liquid filtering, is condensed into extractum, adds acceptable adjuvant or complementary composition on medicament or food and is prepared from preparation;
(2) by weight taking Radix Platycodonis 3 ~ 18 parts respectively, 2 ~ 20 parts, Poria, Rhizoma Chuanxiong 3 ~ 12 parts, the Radix Angelicae Dahuricae 3 ~ 12 parts, Ramulus Uncariae Cum Uncis 5 ~ 16 parts, Caulis Polygoni Multiflori 5 ~ 20 parts, and be ground into coarse powder, get the Radix Platycodonis of the amount of taking, Poria, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Ramulus Uncariae Cum Uncis, Caulis Polygoni Multiflori coarse powder, by 60-95% alcohols soak extraction or heating extraction, extracting liquid filtering, be condensed into extractum, with n-butanol extraction after extractum use water suspendible, reclaim butanol extraction liquid and obtain extractum, add acceptable adjuvant or complementary composition on medicament or food and be prepared from preparation;
(3) by weight taking Radix Platycodonis 3 ~ 18 parts respectively, 2 ~ 20 parts, Poria, Rhizoma Chuanxiong 3 ~ 12 parts, the Radix Angelicae Dahuricae 3 ~ 12 parts, Ramulus Uncariae Cum Uncis 5 ~ 16 parts, Caulis Polygoni Multiflori 5 ~ 20 parts, and be ground into coarse powder, get the Radix Platycodonis of the amount of taking, Poria, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Ramulus Uncariae Cum Uncis, Caulis Polygoni Multiflori coarse powder, by 60-95% alcohols soak extraction or heating extraction, extracting liquid filtering, be condensed into extractum, be extracted with ethyl acetate after extractum water suspendible, reclaim acetic acid ethyl acetate extract and obtain extractum, add acceptable adjuvant or complementary composition on medicament or food and be prepared from preparation.
5. a kind of compositions of preventing and treating acute high altitude reaction and anoxia enduring according to claim 1 or 2 or 3, it is characterized in that: described compositions is pharmaceutical preparation, described pharmaceutical preparation comprises tablet, granule, powder, pill, teabag, capsule, decoction, oral solutions, drop pill or syrup.
6. Chinese medicine extract according to claim 4 is preparing the application in the medicine of anoxia enduring, health product and food.
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| CN201510089468.7A Pending CN104706771A (en) | 2015-02-27 | 2015-02-27 | Composition with anti-anoxia and acute high-altitude reaction prevention and treatment effects |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2020062912A1 (en) | 2018-09-25 | 2020-04-02 | 中国人民解放军总医院 | Medical application of pyrimidine sulfonamides derivatives |
| WO2020062913A1 (en) | 2018-09-25 | 2020-04-02 | 中国人民解放军总医院 | Medical use of prostacyclin receptor agonist |
| CN111346185A (en) * | 2020-05-09 | 2020-06-30 | 南京圣诺生物科技实业有限公司 | Traditional Chinese medicine composition with hypoxia tolerance, preparation method and application |
| CN112603956A (en) * | 2021-01-11 | 2021-04-06 | 贵州中医药大学 | Traditional Chinese medicine compound preparation for preventing acute altitude stress |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2020062912A1 (en) | 2018-09-25 | 2020-04-02 | 中国人民解放军总医院 | Medical application of pyrimidine sulfonamides derivatives |
| WO2020062913A1 (en) | 2018-09-25 | 2020-04-02 | 中国人民解放军总医院 | Medical use of prostacyclin receptor agonist |
| CN111346185A (en) * | 2020-05-09 | 2020-06-30 | 南京圣诺生物科技实业有限公司 | Traditional Chinese medicine composition with hypoxia tolerance, preparation method and application |
| CN112603956A (en) * | 2021-01-11 | 2021-04-06 | 贵州中医药大学 | Traditional Chinese medicine compound preparation for preventing acute altitude stress |
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