CN105998591A - Medicament for curing acute infective endocarditis and preparation method of medicament - Google Patents

Medicament for curing acute infective endocarditis and preparation method of medicament Download PDF

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CN105998591A
CN105998591A CN201610598025.5A CN201610598025A CN105998591A CN 105998591 A CN105998591 A CN 105998591A CN 201610598025 A CN201610598025 A CN 201610598025A CN 105998591 A CN105998591 A CN 105998591A
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medicament
herba
radix
radix ginseng
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张淑丽
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    • A61K36/18Magnoliophyta (angiosperms)
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Abstract

The invention discloses a medicament for curing acute infective endocarditis. The medicament is prepared from the following main raw materials in parts by weight: 5-10 parts of honeysuckle flower, 4-9 parts of radix clerodendrum cyrtophyllum, 10-20 parts of cortex dictamni, 10-20 parts of fruit of cubeb litsea tree, 5-15 parts of rhizoma anemarrhenae, 7-13 parts of folium isatidis, 4-10 parts of herba scuteliariae barbatae, 5-10 parts of purslane herb, 3-7 parts of radix berberidis, 2-4 parts of herba siphonostegiae, 5-10 parts of fructus schisandrae chinensis, 3-8 parts of peach kernel and 5-15 parts of radix et rhizoma ginseng. The raw medical materials are easy to obtain and low in cost. Due to the fact that the medical materials are moderate in drug property, the medicament cannot increase economical and physical burden if a user uses the medicament for a long time.

Description

The medicament for the treatment of acute infective endocarditis and preparation method
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of medicament treating acute infective endocarditis and system Preparation Method.
Background technology
Acute infective endocarditis (AIE) mostly is a part for severe systemic infection, and pathogenic microorganism strong toxicity, such as gold Staphylococcus aureus (most common, to account for more than 50%) and fungus etc., and patient's many acardias medical history.AIE progress is hurried, and a couple of days is extremely Valve can be caused several weeks to destroy, occur that cardiac murmur or original noise character change in a short time, can rapid progression be acute congestion DHF;And it is common to infect migration.Due to primary disease systemic infection serious symptom, acute infective endocarditis can be covered Clinical manifestation.
The cause of disease: acute infective endocarditis often causes, how by the disease that virulence is stronger because suppurative bacterium invades endocardium Caused by pathogen infection.Due to generally taking of broad ectrum antibiotic, pathogenic species changes, and many pathogenic microorganism all can cause Acute infective endocarditis.Such as staphylococcus aureus, streptococcus, including different types of variant.Wherein staphylococcus Infect the main reason for the iatrogenic infective endocarditis with intravenous drug misuser.Cardiac pacemaker infects and mostly is Staphylococcus epidermidis and infection of staphylococcus aureus.Fungus is more common in operation on heart and intravenous injection junker In.
Clinical manifestation: acute infective endocarditis is multiple is born in normal heart.1. onset and general status: onset is usually dashed forward So, the high heat of companion, shiver with cold, whole body toxemia synptom is obvious, and endocarditis is often a part for severe systemic infection, and how hurried the course of disease is Dangerous.2., can newly there is cardiac murmur or original heart to a high-profile in heart change: cardiac valve and the acute lesion of chordae tendineae Dirty noise character changes.And can rapid progression be acute congestive heart failure, even dead.Patient may occur in which arrhythmia. The right heart infective endocarditis of intravenous drug misuser mostly also is acute infective endocarditis.3. thromboembolism and transitivity pus Swelling and can adhere to big and crisp vegetation on the endocardium got involved, the bacterium bolt come off can cause thromboembolism and metastatic abscess, can have Abscess,myocardial, brain abscess and purulent meningitis etc..If right heart infective endocarditis vegetation comes off, may occur in which pneumonia, lung Arterial thrombosis and pulmonary abscess etc..4. hemorrhagic erythra seen from skin.5. small number of patients may occur in which splenomegaly.
Treat the principle of the application application antibiotic of 1. antibiotic: apply in early days;Enough medications;Intravenous administration is main;Sick Select when pathogenic microorganism is failed to understand for all effective broad ectrum antibiotic of staphylococcus aureus, streptococcus and gram negative bacilli; Separated go out pathogenic microorganism time, according to pathogenic microorganism, the sensitivity of medicine should be selected antimicrobial agents.2. operation is controlled Treat
Following situation need to consider operative treatment: 1. perforated valve, rupture, chordae tendineae detachment, there is intractable acute heart failure;② Prosthetic heart valves infects, and medical treatment can not control;3. concurrency thromboembolism or suppurative complication, such as suppurative pericardium Inflammation, abscess,myocardial etc.;4. the gram negative bacilli of the out of contior infection of other drug, especially fungoid and antibiotics resistance Endocarditis;4. cardiac pacemaker infective endocarditis advocates that the electrode cable infected is taken out in operation.It is known that: antibiotic Treatment is not very well to health, can destroy healthy, and along with the development of Chinese medicine, people recognize oral Chinese medicine gradually Very important status is occupied on treatment primary disease.
In the Chinese medicine of existing treatment acute infective endocarditis, application publication number CN 105250878 A(application number 201510724418.1) patent documentation discloses a kind of Chinese medicine treating subacute infective endocarditis, it is characterised in that: Raw material including following weight proportion: Herba Cyperi Flabelliformis 10-20 part, Semen Ricini 10-20 part, Caulis Spatholobi 6-16 part, Radix Angelicae Sinensis 6-16 Part, Herba Kalimeridis 5-12 part, Radix Dipsaci 5-12 part, Flos Caryophylli 6-18 part, Fructus Trichosanthis 5-12 part, Fructus Amomi 5-12 part, Folium Isatidis 5-12 part, Nidus Vespae 5-12 part, Fructus Piperis Longi 5-15 part, Radix Ophiopogonis 5-15 part, Radix Polygalae 5-15 part, Lithargyrum's 5-15 part, Fructus Arctii 5-15 Part, Herba Blumeae Balsamiferae 6-16 part, Radix Aucklandiae 6-16 part, Fructus Mume 6-18 part, Herba Ipomoeae Cairicae 6-18 part, Rhizoma Arisaematis 6-18 part, Mel 6-18 Part, Radix Glycyrrhizae 6-18 part.Application publication number CN 105477111 A(application number 201410477178.5) patent documentation open One treats subacute infective endocarditis Chinese medicine preparation, the raw material of following parts by weight prepare: Herba Andrographis 6 ~ 15 Part, garlicin 5 ~ 12 parts, 9 ~ 18 parts of Radix Glycyrrhizae, Caulis Lonicerae 5 ~ 10 parts, Radix Sophorae Flavescentis 5 ~ 10 parts, Herba Lycopodii serrati 1 ~ 5 part, the Radix Pulsatillae 8 ~ 12 parts, Fructus Mume 9 ~ 15 parts, pears 6 ~ 15 parts, Rhizoma Coptidis 9 ~ 15 parts, 1 ~ 6 part of Semen Persicae, Rhizoma Anemarrhenae 3 ~ 6 parts, Herba Artemisiae Scopariae 6 ~ 9 parts, four Season green grass or young crops 5 ~ 12 parts.
As can be seen here, Chinese medicine occupies very important status in terms for the treatment of acute infective endocarditis, but patent In document, it is not specifically designed to the medicament for the treatment of acute infective endocarditis.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide the medicine for the treatment of acute infective endocarditis Agent, medical material medicine source of the present invention is easy to get, and with low cost, selected medical material mostly is the thing of mild in medicine property sum, and long-term taking also will not be taken Person increases the burden on economy and health.
Another object of the present invention is just to provide the preparation method of above-mentioned medicament.
The technical scheme is that
The medicament for the treatment of acute infective endocarditis, takes off and states the primary raw material of weight proportion and be prepared from: Flos Lonicerae 5-10 Part, soil Cortex Lycii 4-9 part, Cortex Dictamni 10-20 part, Fructus Litseae 10-20 part, Rhizoma Anemarrhenae 5-15 part, Folium Isatidis 7-13 part, Herba Scutellariae Barbatae 4- 10 parts, Herba Portulacae 5-10 part, Radix Berberidis 3-7 part, Herba Artemisiae Anomalae 2-4 part, Fructus Schisandrae Chinensis 5-10 part, Semen Persicae 3-8 part, Radix Ginseng 5-15 part.
The medicament for the treatment of acute infective endocarditis, preferred scheme is, takes off the primary raw material system stating weight proportion For forming: Flos Lonicerae 6-9 part, soil Cortex Lycii 5-8 part, Cortex Dictamni 13-18 part, Fructus Litseae 13-18 part, Rhizoma Anemarrhenae 8-13 part, Folium Isatidis Leaf 9-11 part, Herba Scutellariae Barbatae 6-8 part, Herba Portulacae 6-9 part, Radix Berberidis 4-6 part, Herba Artemisiae Anomalae 2.5-3.5 part, Fructus Schisandrae Chinensis 6-9 part, Semen Persicae 4-7 part, Radix Ginseng 8-13 part.
The medicament for the treatment of acute infective endocarditis, the scheme being more highly preferred to is, takes off and states the most former of weight proportion Material is prepared from: Flos Lonicerae 7.5 parts, soil Cortex Lycii 6.5 parts, Cortex Dictamni 15 parts, Fructus Litseae 15 parts, the Rhizoma Anemarrhenae 10 parts, Folium Isatidis 10 Part, Herba Scutellariae Barbatae 7 parts, Herba Portulacae 7.5 parts, Radix Berberidis 5 parts, Herba Artemisiae Anomalae 3 parts, Fructus Schisandrae Chinensis 8 parts, 5.5 parts of Semen Persicae, Radix Ginseng 10 parts.
The preparation method of above-mentioned medicament, step is as follows:
(1) fresh Herba portulacae is cut into the fourth of soybean grain size, is placed in glass container, add white vinegar, soak 30-60 and divide Clock, takes out soaked Herba portulacae fourth, smashs to pieces stand-by;
(2) soil Cortex Lycii, Herba Artemisiae Anomalae and Fructus Schisandrae Chinensis being placed on clean tile, little fire presss from both sides with clip after drying slowly 12-24 minute In crock, close the lid and teetertotter, take out and grind to form smalls to cross 80-120 mesh sieve stand-by;
(3) Radix Ginseng is cleaned up, drain away the water, cut into slices stand-by, take a transparent container, be placed on electromagnetic oven, add Entering rice vinegar, boil boiling, put into Radix Ginseng slice while hot, soak 5-10 hour, taking-up Radix Ginseng slice's parch is crisp, grinds to form smalls and treats With, filtrate stands;
(4) by Semen Persicae baking crisp outside tender inside, dry in the air cool, grind to form smalls stand-by;
(5) by Flos Lonicerae, Cortex Dictamni, Fructus Litseae, the Rhizoma Anemarrhenae, Folium Isatidis, Herba Scutellariae Barbatae and Radix Berberidis saline soak 50-70 minute, Filtering, filtering residue is placed in the hot pot dryouied, repeatedly stir-fries to crisp, grind to form smalls stand-by;
(6) by step (1) gained Herba portulacae and step (2)-(5) gained smalls mixing, it is placed in marmite, addition step slowly (2) gained filtrate, heats to stir and fully dissolves to smalls, stand 4-6 hour, take supernatant, bottle and i.e. obtain medicament.
The preparation method of above-mentioned medicament, step (1) adds white vinegar, soaks 40-50 minute and (preferably, adds white vinegar, soak 45 minutes).
The preparation method of above-mentioned medicament, (preferably, step (2) little fire clips in crock with clip after drying slowly 16-20 minute Little fire clips in crock with clip after drying 18 minutes slowly).
The preparation method of above-mentioned medicament, the consumption of step (3) rice vinegar is 15-20 times of (preferably, rice vinegar of Radix Ginseng weight Consumption is 16-19 times of Radix Ginseng weight, and more preferably, the consumption of rice vinegar is 18 times of Radix Ginseng weight).
The preparation method of above-mentioned medicament, step (3) is put into Radix Ginseng slice while hot, is soaked 6-9 hour and (preferably, put into while hot Radix Ginseng slice, soaks 7.5 hours).
The preparation method of above-mentioned medicament, step (5) by Flos Lonicerae, Cortex Dictamni, Fructus Litseae, the Rhizoma Anemarrhenae, Folium Isatidis, Herba Scutellariae Barbatae and Radix Berberidis with saline soak 55-65 minute (preferably, by Flos Lonicerae, Cortex Dictamni, Fructus Litseae, the Rhizoma Anemarrhenae, Folium Isatidis, Herba Scutellariae Barbatae and Radix Berberidis saline soak 60 minutes).
The preparation method of above-mentioned medicament, step (6) heats to stir fully dissolves to smalls, stands 4.5-5.5 Hour (preferably, heat to stir and fully dissolve to smalls, stand 5 hours).
Optimal instructions of taking: for making the present invention reach optimal therapeutic effect, the medicament made, 8 of every morning and Take 2ml at 1 of afternoon, within 5 days, be a course for the treatment of.
The pharmacological effect of each crude drug is respectively as follows:
Flos Lonicerae: modern study proves, Flos Lonicerae contains the pharmacological component such as chlorogenic acid, luteolin glycosides, to hemolytic chain The various pathogens such as coccus, staphylococcus aureus and upper respiratory tract infection Causative virus etc. have stronger restraint, the most also may be used Enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, antiinflammatory, antipyretic, hemostasis (blood coagulation), suppression intestinal absorption cholesterol etc., it faces Bed purposes widely, can be used for treating respiratory tract infection, bacillary dysentery, acute urinary, high blood with other medicines compatibility Pressure etc. more than 40 kind disease.
Soil Cortex Lycii: control encephalitis b, epidemic encephalitis, the high heat of flu, headache, enteritis, dysentery, jaundice, toothache, epistaxis, laryngopharynx swelling and pain. Soil Cortex Lycii is an alias of Radix Clerodenri Cyrtophylli, for the root of Verbenaceae Herba Diclipterae Chinensis, has heat clearing away, removing toxic substances, dispels the wind, dehumidifying Etc. effect.
Cortex Dictamni: for Rutaceae herbaceos perennial shaggy-fruited dittany and the root bark of Dictamnus angustifolius.There is heat clearing and damp drying, solution of dispeling the wind Effect of poison." property of medicine opinion ": controlling all pyretic toxicity wind, aversion to wind, wind skin ulcer, scabies are red rotten, and eyebrow loss of hairs is crisp, musculus cutaneus is anxious, high fever aversion to cold;Main Antipyretic Huang, wine Huang, acute jaundice, yellow, the labor Huang of paddy etc..
Fructus Litseae: bitter, cold;Poisonous.Return liver, stomach, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.For damp-heat dysentery, jaundice, Eczema, pharyngalgia conjunctival congestion, discharging ear, carbuncle sore tumefacting virus.
The Rhizoma Anemarrhenae: return lung, stomach, kidney channel.Rhizoma Anemarrhenae effect clearing away heat-fire is nourshing Yin and drynsessmoistening prescription.The Rhizoma Anemarrhenae cures mainly calentura excessive thirst, and lung-heat is dry Coughing, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Folium Isatidis: bitter, cold.GUIXIN, stomach warp.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.For epidemic febrile disease high heat, coma, send out speckle dermexanthesis, Mumps, sore throat, erysipelas, carbuncle.
Herba Scutellariae Barbatae: pungent, bitter, cold.Return lung, liver, kidney channel.Heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, Fall and flutter the pain of injury, edema, jaundice, snake bite and insect sting.
Herba Portulacae: acid, cold.Return liver, large intestine channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis, dysentery relieving.For toxic-heat and blood stasis, carbuncle furuncle Skin ulcer, eczema, erysipelas, snake bite and insect sting, have blood in stool, hemorrhoidal bleeding, metrostaxis.
Radix Berberidis: bitter, cold;Poisonous.Return liver, stomach, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.For damp-heat dysentery, jaundice, Eczema, pharyngalgia conjunctival congestion, discharging ear, carbuncle sore tumefacting virus.
Herba Artemisiae Anomalae: removing blood stasis with potent drugs stimulates the menstrual flow;Hemostasia and detumescence;Promoting digestion and removing stagnation.Main warp closes;Dysmenorrhea;Puerperal the stagnant stomachache of the stasis of blood;Lochiorrhea, Lump in the abdomen;Traumatic injury;Incised wound is hemorrhage;Rheumatic arthralgia;Have blood in stool;Hematuria;Ulcerative carbuncle toxic swelling;Scald;Abdominal pain due to retention of food;Dysentery.
Fructus Schisandrae Chinensis: for famous Chinese medicine, its fruit is containing schizandrin (Schisandrin C23H3206) and vitamin C, tree Fat, tannin and a small amount of saccharide.There are astringing lung-QI and relieving cough, nourishing arresting seminal emission, the effect of antidiarrheal hidroschesis.Its leaf, fruit can extract aromatic oil.Kernel Containing fatty oil, oil expression can make the raw material of industry, lubricating oil.Peel of stem fiber is pliable and tough, is available for rope.Astringe the lung, nourishing kidney, promote the production of body fluid, receive antiperspirant, Arresting seminal emission.Controlling the deficiency of the lung to breath with cough, xerostomia is made thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.
Semen Persicae: there is blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, effect of relieving cough and asthma.For amenorrhea dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, lung abscess Acute appendicitis, injury from falling down, dryness of the intestine constipation, cough and asthma.
Radix Ginseng: cure mainly: weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung breathes with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness Weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb;Heart failure, cardiogenic shock.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hyperhidrosis, food Few the most unable, all acute and chronic diseases and the shock caused after losing blood, collapse.Strongly invigorating primordial QI, promotes the production of body fluid Gu de-, calms the nerves.Control impairment caused by overstrain empty Damaging, lack of appetite, asthenia, food is told in regurgitation, lingering diarrhea of defecating, and empty cough with asthma promotees, spontaneous perspiration sudden collapse, and palpitation with fear is forgetful, dizziness and headache, sexual impotence, urine Frequently, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the card of all qi-blood-body fluid deficiencies.
1, medicament of the present invention " focuses on entirety ", both can treat acute infective endocarditis, again can tranquilizing by nourishing the heart and treatment Angina pectoris, cardiopalmus etc., this medicament is based entirely on Chinese medicine principle and is prepared from, more safe and reliable, without any side effects, To matrix without any stimulation.
2, medical material compatibility selected by Chinese medicine preparation of the present invention is suitable, uses modern advanced pharmaceutical technology to make, evident in efficacy, Safe without toxic side effect, treating both the principal and secondary aspects of a disease, should be widely promoted application.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited by this.
Embodiment 1 treats the medicament of acute infective endocarditis, takes off and states the primary raw material of weight proportion and be prepared from: Flos Lonicerae 5 grams, soil Cortex Lycii 4 grams, Cortex Dictamni 10 grams, Fructus Litseae 10 grams, the Rhizoma Anemarrhenae 5 grams, Folium Isatidis 7 grams, Herba Scutellariae Barbatae 4 grams, Dens Equi Herba Amaranthi tricoloris 5 grams, Radix Berberidis 3 grams, Herba Artemisiae Anomalae 2 grams, Fructus Schisandrae Chinensis 5 grams, 3 grams of Semen Persicae, Radix Ginseng 5 grams.
The preparation method of above-mentioned medicament, step is as follows:
(1) fresh Herba portulacae is cut into the fourth of soybean grain size, is placed in glass container, add white vinegar, soak 30 minutes, take Go out soaked Herba portulacae fourth, smash to pieces stand-by;
(2) soil Cortex Lycii, Herba Artemisiae Anomalae and Fructus Schisandrae Chinensis being placed on clean tile, little fire clips to watt with clip after drying 12 minutes slowly In tank, close the lid and teetertotter, take out and grind to form smalls to cross 80 mesh sieves stand-by;
(3) Radix Ginseng is cleaned up, drain away the water, cut into slices stand-by, take a transparent container, be placed on electromagnetic oven, add Entering rice vinegar, boil boiling, put into Radix Ginseng slice while hot, soak 5 hours, it is crisp to take out Radix Ginseng slice's parch, and it is stand-by to grind to form smalls, filter Liquid stands;
(4) by Semen Persicae baking crisp outside tender inside, dry in the air cool, grind to form smalls stand-by;
(5) by Flos Lonicerae, Cortex Dictamni, Fructus Litseae, the Rhizoma Anemarrhenae, Folium Isatidis, Herba Scutellariae Barbatae and Radix Berberidis saline soak 50 minutes, mistake Filter, filtering residue is placed in the hot pot dryouied, repeatedly stir-fries to crisp, grind to form smalls stand-by;
(6) by step (1) gained Herba portulacae and step (2)-(5) gained smalls mixing, it is placed in marmite, addition step slowly (2) gained filtrate, heats to stir and fully dissolves to smalls, stand 4 hours, take supernatant, bottle and i.e. obtain medicament.
Model case one: Zou XX, female, 58 years old, Jinan, Shandong Province people from Jiyang, there is hypertension 2 years, because of height when of 2012 Blood pressure causes cerebral thrombosis, is almost recovered after treatment in hospital, but half a year recently, the Fa Gaore of unknown cause sometimes, entirely Body is unable, not eating, the symptom such as tired, and household is afraid of again to recur cerebral thrombosis, checks with regard to band patient Qu Wo city large hospital, makes a definite diagnosis For acute infective endocarditis, doctor has opened gained medicament of the present invention to it.
Taking the present embodiment 1 gained medicament, after 3 days, whole body has strength, appetite also to increase, and continues to take medicine 5 days, additional Taking exercise, health is progressively got well, and patient's self-induction is fully recovered.
Embodiment 2 treats the medicament of acute infective endocarditis, take off state weight proportion primary raw material preparation and Become: Flos Lonicerae 10 grams, soil Cortex Lycii 9 grams, Cortex Dictamni 20 grams, Fructus Litseae 20 grams, the Rhizoma Anemarrhenae 15 grams, Folium Isatidis 13 grams, Herba Scutellariae Barbatae 10 Gram, Herba Portulacae 10 grams, Radix Berberidis 7 grams, Herba Artemisiae Anomalae 4 grams, Fructus Schisandrae Chinensis 10 grams, 8 grams of Semen Persicae, Radix Ginseng 15 grams.
The preparation method of above-mentioned medicament, step is as follows:
(1) fresh Herba portulacae is cut into the fourth of soybean grain size, is placed in glass container, add white vinegar, soak 60 minutes, take Go out soaked Herba portulacae fourth, smash to pieces stand-by;
(2) soil Cortex Lycii, Herba Artemisiae Anomalae and Fructus Schisandrae Chinensis being placed on clean tile, little fire clips to watt with clip after drying 24 minutes slowly In tank, close the lid and teetertotter, take out and grind to form smalls to cross 120 mesh sieves stand-by;
(3) Radix Ginseng is cleaned up, drain away the water, cut into slices stand-by, take a transparent container, be placed on electromagnetic oven, add Entering rice vinegar, boil boiling, put into Radix Ginseng slice while hot, soak 10 hours, it is crisp to take out Radix Ginseng slice's parch, and it is stand-by to grind to form smalls, Filtrate stands;
(4) by Semen Persicae baking crisp outside tender inside, dry in the air cool, grind to form smalls stand-by;
(5) by Flos Lonicerae, Cortex Dictamni, Fructus Litseae, the Rhizoma Anemarrhenae, Folium Isatidis, Herba Scutellariae Barbatae and Radix Berberidis saline soak 70 minutes, mistake Filter, filtering residue is placed in the hot pot dryouied, repeatedly stir-fries to crisp, grind to form smalls stand-by;
(6) by step (1) gained Herba portulacae and step (2)-(5) gained smalls mixing, it is placed in marmite, addition step slowly (2) gained filtrate, heats to stir and fully dissolves to smalls, stand 6 hours, take supernatant, bottle and i.e. obtain medicament.
Embodiment 3 treats the medicament of acute infective endocarditis, take off state weight proportion primary raw material preparation and Become: Flos Lonicerae 6 grams, soil Cortex Lycii 5 grams, Cortex Dictamni 13 grams, Fructus Litseae 13 grams, the Rhizoma Anemarrhenae 8 grams, Folium Isatidis 9 grams, Herba Scutellariae Barbatae 6 grams, horse Bitterroot 6 grams, Radix Berberidis 4 grams, Herba Artemisiae Anomalae 2.5 grams, Fructus Schisandrae Chinensis 6 grams, 4 grams of Semen Persicae, Radix Ginseng 8 grams.
Stating the preparation method of medicament, step is as follows:
(1) fresh Herba portulacae is cut into the fourth of soybean grain size, is placed in glass container, add white vinegar, soak 40 minutes, take Go out soaked Herba portulacae fourth, smash to pieces stand-by;
(2) soil Cortex Lycii, Herba Artemisiae Anomalae and Fructus Schisandrae Chinensis being placed on clean tile, little fire clips to watt with clip after drying 16 minutes slowly In tank, close the lid and teetertotter, take out and grind to form smalls to cross 90 mesh sieves stand-by;
(3) Radix Ginseng is cleaned up, drain away the water, cut into slices stand-by, take a transparent container, be placed on electromagnetic oven, add Entering rice vinegar, boil boiling, put into Radix Ginseng slice while hot, soak 6 hours, it is crisp to take out Radix Ginseng slice's parch, and it is stand-by to grind to form smalls, filter Liquid stands;
(4) by Semen Persicae baking crisp outside tender inside, dry in the air cool, grind to form smalls stand-by;
(5) by Flos Lonicerae, Cortex Dictamni, Fructus Litseae, the Rhizoma Anemarrhenae, Folium Isatidis, Herba Scutellariae Barbatae and Radix Berberidis saline soak 55 minutes, mistake Filter, filtering residue is placed in the hot pot dryouied, repeatedly stir-fries to crisp, grind to form smalls stand-by;
(6) by step (1) gained Herba portulacae and step (2)-(5) gained smalls mixing, it is placed in marmite, addition step slowly (2) gained filtrate, heats to stir and fully dissolves to smalls, stand 4.5 hours, take supernatant, bottle and i.e. obtain medicament.
Model case two: Zhu XX, man, 68 years old, Jinan, Shandong Province personage, suffer from arrhythmia, angina pectoris 2 years, through treatment The most substantially recover symptom, heating, the symptom of cardiopalmus occur after recent drug withdrawal, and is long-term fever, irregular pattern of fever, the most seriously When feel that oneself soon suffocates, heartbeat very fast, is acute infective endocarditis after diagnosing.
Taking the present embodiment 3 gained medicament, take 5 days, health progressively recovers, and appetite strengthens, and continues to take 5 days, patient Uncomfortable disease disappears substantially, and self-induction is fully recovered.
Embodiment 4 treats the medicament of acute infective endocarditis, take off state weight proportion primary raw material preparation and Become: Flos Lonicerae 9 grams, soil Cortex Lycii 8 grams, Cortex Dictamni 18 grams, Fructus Litseae 18 grams, the Rhizoma Anemarrhenae 13 grams, Folium Isatidis 11 grams, Herba Scutellariae Barbatae 8 grams, Herba Portulacae 9 grams, Radix Berberidis 6 grams, Herba Artemisiae Anomalae 3.5 grams, Fructus Schisandrae Chinensis 9 grams, 7 grams of Semen Persicae, Radix Ginseng 13 grams.
The preparation method of above-mentioned medicament, step is as follows:
(1) fresh Herba portulacae is cut into the fourth of soybean grain size, is placed in glass container, add white vinegar, soak 50 minutes, take Go out soaked Herba portulacae fourth, smash to pieces stand-by;
(2) soil Cortex Lycii, Herba Artemisiae Anomalae and Fructus Schisandrae Chinensis being placed on clean tile, little fire clips to watt with clip after drying 20 minutes slowly In tank, close the lid and teetertotter, take out and grind to form smalls to cross 110 mesh sieves stand-by;
(3) Radix Ginseng is cleaned up, drain away the water, cut into slices stand-by, take a transparent container, be placed on electromagnetic oven, add Entering rice vinegar, boil boiling, put into Radix Ginseng slice while hot, soak 9 hours, it is crisp to take out Radix Ginseng slice's parch, and it is stand-by to grind to form smalls, filter Liquid stands;
(4) by Semen Persicae baking crisp outside tender inside, dry in the air cool, grind to form smalls stand-by;
(5) by Flos Lonicerae, Cortex Dictamni, Fructus Litseae, the Rhizoma Anemarrhenae, Folium Isatidis, Herba Scutellariae Barbatae and Radix Berberidis saline soak 65 minutes, mistake Filter, filtering residue is placed in the hot pot dryouied, repeatedly stir-fries to crisp, grind to form smalls stand-by;
(6) by step (1) gained Herba portulacae and step (2)-(5) gained smalls mixing, it is placed in marmite, addition step slowly (2) gained filtrate, heats to stir and fully dissolves to smalls, stand 5.5 hours, take supernatant, bottle and i.e. obtain medicament.
Embodiment 5 treats the medicament of acute infective endocarditis, take off state weight proportion primary raw material preparation and Become: Flos Lonicerae 7.5 grams, soil Cortex Lycii 6.5 grams, Cortex Dictamni 15 grams, Fructus Litseae 15 grams, the Rhizoma Anemarrhenae 10 grams, Folium Isatidis 10 grams, Herba Scutellariae Barbatae 7 grams, Herba Portulacae 7.5 grams, Radix Berberidis 5 grams, Herba Artemisiae Anomalae 3 grams, Fructus Schisandrae Chinensis 8 grams, 5.5 grams of Semen Persicae, Radix Ginseng 10 grams.
The preparation method of above-mentioned medicament, step is as follows:
(1) fresh Herba portulacae is cut into the fourth of soybean grain size, is placed in glass container, add white vinegar, soak 45 minutes, take Go out soaked Herba portulacae fourth, smash to pieces stand-by;
(2) soil Cortex Lycii, Herba Artemisiae Anomalae and Fructus Schisandrae Chinensis being placed on clean tile, little fire clips to watt with clip after drying 18 minutes slowly In tank, close the lid and teetertotter, take out and grind to form smalls to cross 100 mesh sieves stand-by;
(3) Radix Ginseng is cleaned up, drain away the water, cut into slices stand-by, take a transparent container, be placed on electromagnetic oven, add Entering rice vinegar, boil boiling, put into Radix Ginseng slice while hot, soak 8 hours, it is crisp to take out Radix Ginseng slice's parch, and it is stand-by to grind to form smalls, filter Liquid stands;
(4) by Semen Persicae baking crisp outside tender inside, dry in the air cool, grind to form smalls stand-by;
(5) by Flos Lonicerae, Cortex Dictamni, Fructus Litseae, the Rhizoma Anemarrhenae, Folium Isatidis, Herba Scutellariae Barbatae and Radix Berberidis saline soak 60 minutes, mistake Filter, filtering residue is placed in the hot pot dryouied, repeatedly stir-fries to crisp, grind to form smalls stand-by;
(6) by step (1) gained Herba portulacae and step (2)-(5) gained smalls mixing, it is placed in marmite, addition step slowly (2) gained filtrate, heats to stir and fully dissolves to smalls, stand 5 hours, take supernatant, bottle and i.e. obtain medicament.
The clinical practice of the medicament of test example 1 embodiment 5 gained treatment acute infective endocarditis: we randomly draw 400 patients test (400 acute infective endocarditis patients), are divided into experimental group and matched group, Qi Zhongnv Property 200 examples, male 200 example.Before test 1 day, this crowd is carried out Continuous Observation, record symptom and change, is randomly divided into two Group, experimental group and matched group, experimental group takes embodiment 5 products obtained therefrom, and it is intracardiac that matched group takes other treatment samples The medicine that film is scorching.
Efficacy evaluation: allow patient state the degree picked body oneself felt, is respectively high hot, uncomfortable in chest, cardiopalmus, food Be intended to depressed, insomnia, the symptom of dreaminess;The highest heat, uncomfortable in chest, cardiopalmus, inappetence, insomnia, dreaminess symptom are improved as effective, high Hot, uncomfortable in chest, cardiopalmus, inappetence, insomnia, dreaminess symptom unchanged for invalid.
Specific experiment result such as following table:
Table 1:
Therapeutic effect: pharmaceutical treatment effect of the present invention is substantially better than matched group, takes period, and malaise symptoms or pair occurs in no one Effect.

Claims (10)

1. treat acute infective endocarditis medicament, it is characterised in that: take off state weight proportion primary raw material preparation and Become: Flos Lonicerae 5-10 part, soil Cortex Lycii 4-9 part, Cortex Dictamni 10-20 part, Fructus Litseae 10-20 part, Rhizoma Anemarrhenae 5-15 part, Folium Isatidis 7- 13 parts, Herba Scutellariae Barbatae 4-10 part, Herba Portulacae 5-10 part, Radix Berberidis 3-7 part, Herba Artemisiae Anomalae 2-4 part, Fructus Schisandrae Chinensis 5-10 part, Semen Persicae 3-8 Part, Radix Ginseng 5-15 part.
The medicament for the treatment of acute infective endocarditis the most according to claim 1, it is characterised in that: take following weight and join The primary raw material of ratio is prepared from: Flos Lonicerae 6-9 part, soil Cortex Lycii 5-8 part, Cortex Dictamni 13-18 part, and Fructus Litseae 13-18 part is known Female 8-13 part, Folium Isatidis 9-11 part, Herba Scutellariae Barbatae 6-8 part, Herba Portulacae 6-9 part, Radix Berberidis 4-6 part, Herba Artemisiae Anomalae 2.5-3.5 part, five Taste 6-9 part, Semen Persicae 4-7 part, Radix Ginseng 8-13 part.
The medicament for the treatment of acute infective endocarditis the most according to claim 1, it is characterised in that: take following weight and join The primary raw material of ratio is prepared from: Flos Lonicerae 7.5 parts, soil Cortex Lycii 6.5 parts, Cortex Dictamni 15 parts, Fructus Litseae 15 parts, the Rhizoma Anemarrhenae 10 Part, Folium Isatidis 10 parts, Herba Scutellariae Barbatae 7 parts, Herba Portulacae 7.5 parts, Radix Berberidis 5 parts, Herba Artemisiae Anomalae 3 parts, Fructus Schisandrae Chinensis 8 parts, 5.5 parts of Semen Persicae, Radix Ginseng 10 parts.
4., according to the preparation method of the medicament treating acute infective endocarditis described in any one of claim 1-3, it is special Levy and be: step is as follows:
(1) fresh Herba portulacae is cut into the fourth of soybean grain size, is placed in glass container, add white vinegar, soak 30-60 and divide Clock, takes out soaked Herba portulacae fourth, smashs to pieces stand-by;
(2) soil Cortex Lycii, Herba Artemisiae Anomalae and Fructus Schisandrae Chinensis being placed on clean tile, little fire presss from both sides with clip after drying slowly 12-24 minute In crock, close the lid and teetertotter, take out and grind to form smalls to cross 80-120 mesh sieve stand-by;
(3) Radix Ginseng is cleaned up, drain away the water, cut into slices stand-by, take a transparent container, be placed on electromagnetic oven, add Entering rice vinegar, boil boiling, put into Radix Ginseng slice while hot, soak 5-10 hour, taking-up Radix Ginseng slice's parch is crisp, grinds to form smalls and treats With, filtrate stands;
(4) by Semen Persicae baking crisp outside tender inside, dry in the air cool, grind to form smalls stand-by;
(5) by Flos Lonicerae, Cortex Dictamni, Fructus Litseae, the Rhizoma Anemarrhenae, Folium Isatidis, Herba Scutellariae Barbatae and Radix Berberidis saline soak 50-70 minute, Filtering, filtering residue is placed in the hot pot dryouied, repeatedly stir-fries to crisp, grind to form smalls stand-by;
(6) by step (1) gained Herba portulacae and step (2)-(5) gained smalls mixing, it is placed in marmite, addition step slowly (2) gained filtrate, heats to stir and fully dissolves to smalls, stand 4-6 hour, take supernatant, bottle and i.e. obtain medicament.
The preparation method of medicament the most according to claim 4, it is characterised in that: step (1) adds white vinegar, soaks 40-50 and divides Clock (preferably, adds white vinegar, soaks 45 minutes).
The preparation method of medicament the most according to claim 4, it is characterised in that: step (2) little fire is used after drying slowly 16-20 minute Clip clips to (preferably, little fire clips in crock after drying 18 minutes slowly) in crock with clip.
The preparation method of medicament the most according to claim 4, it is characterised in that: the consumption of step (3) rice vinegar is Radix Ginseng weight 15-20 times (preferably, the consumption of rice vinegar is 16-19 times of Radix Ginseng weight, and more preferably, the consumption of rice vinegar is Radix Ginseng weight 18 times of amount).
The preparation method of medicament the most according to claim 4, it is characterised in that: step (3) puts into Radix Ginseng slice while hot, soaks 6- 9 hours (preferably, put into Radix Ginseng slice while hot, soak 7.5 hours).
The preparation method of medicament the most according to claim 4, it is characterised in that: step (5) is by grey to Flos Lonicerae, Cortex Dictamni, mountain Son, the Rhizoma Anemarrhenae, Folium Isatidis, Herba Scutellariae Barbatae and Radix Berberidis with saline soak 55-65 minute (preferably, by grey to Flos Lonicerae, Cortex Dictamni, mountain Son, the Rhizoma Anemarrhenae, Folium Isatidis, Herba Scutellariae Barbatae and Radix Berberidis saline soak 60 minutes).
The preparation method of medicament the most according to claim 4, it is characterised in that: step (6) heats and stirs to carefully End is fully dissolved, and stands 4.5-5.5 hour (preferably, heat to stir and fully dissolve to smalls, stand 5 hours).
CN201610598025.5A 2016-07-27 2016-07-27 Medicament for curing acute infective endocarditis and preparation method of medicament Pending CN105998591A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105250878A (en) * 2015-10-30 2016-01-20 姜秀芹 Traditional Chinese medicine for treating sub-acute infective endocarditis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105250878A (en) * 2015-10-30 2016-01-20 姜秀芹 Traditional Chinese medicine for treating sub-acute infective endocarditis

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