CN105998544A - Bitter aversive agent and preparation method thereof - Google Patents
Bitter aversive agent and preparation method thereof Download PDFInfo
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- CN105998544A CN105998544A CN201610370181.6A CN201610370181A CN105998544A CN 105998544 A CN105998544 A CN 105998544A CN 201610370181 A CN201610370181 A CN 201610370181A CN 105998544 A CN105998544 A CN 105998544A
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- aversive agent
- aloe
- bitterness
- bitter
- bitter substance
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- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 59
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 55
- 241001116389 Aloe Species 0.000 claims abstract description 53
- 235000019658 bitter taste Nutrition 0.000 claims abstract description 52
- 239000000126 substance Substances 0.000 claims abstract description 44
- 239000000654 additive Substances 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 17
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 30
- 230000000996 additive effect Effects 0.000 claims description 20
- VWTINHYPRWEBQY-UHFFFAOYSA-N denatonium Chemical compound [O-]C(=O)C1=CC=CC=C1.C=1C=CC=CC=1C[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C VWTINHYPRWEBQY-UHFFFAOYSA-N 0.000 claims description 17
- 229960001610 denatonium benzoate Drugs 0.000 claims description 17
- 239000012047 saturated solution Substances 0.000 claims description 15
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 13
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a bitter aversive agent and a preparation method thereof. The aversive agent can consist of a bitter substance carrier, a bitter substance and additives. According to the bitter aversive agent and the preparation method thereof provided by the invention, a fresh aloe original fluid is taken as the bitter substance carrier and is matched with a small quantity of chondroitin, and the bitter substance, assisted by two materials, namely the aloe and the chondroitin, can easily permeate into fingernails and subcutaneous tissues; and after 5min of washing a hand coated with the bitter aversive agent, bitterness is still quite strong. The aversive agent is convenient to coat; the aversive agent is applicable to both the fingernails and skin, and the aversive agent is washing-resistant, wear-resistant, free from preservatives and free from toxic and harmful materials; such allergic substances as calcium oxalate, rheum emodin and the like in aloe leaves are effectively eliminated in a process of preparing the bitter substance carrier, so that the bitter aversive agent is quite suitable for young people and children. The aloe ingredient and the chondroitin are also conducive to the repair of collagen tissues in nail beds and the skin, so as to promote the growth of the nail beds and the repair of the hand skin.
Description
Technical field
The present invention relates to aversive agent technical field, particularly relate to a kind of for assisting correction fingernail biting etc. bad
Bitterness aversive agent of custom and preparation method thereof.
Background technology
The child of about 8 percent and teenager have fingernail biting, gnaw hands skin, eat the misconduct such as finger custom,
This is a kind of learned mental behavior disorder, once and addiction the most obstinate.The correcting method generally acknowledged at present,
It is to coat bitterness aversive agent at the position bitten, allows patient bite after bitterness, fingernail is produced and detests feelings
Thread, forms new trained reflex mechanism, reaches to rescue the purpose of misconduct custom.Although on current market
The relevant treatment product that can have bought, as Germany produces Daum-exol, France produces URGO-STOP, English
Domestic MAMALA-STOP.Though this kind of product category is many, but nothing more than two kinds of dosage forms, one is with water
For bitter substance carrier, it is called for short water preparation；Another kind is with nial polish for bitter substance carrier, is called for short oil preparation.
The advantage of water preparation is that coating scope is wide, wants to be coated with which which is just coated with；Shortcoming be coated with after be difficult to do, bitterness is easily ground
Fall or be washed with water, will be coated with once the most every other hour, and bother very much.Another shortcoming of water preparation is easily to become
Matter, Producer has to add the preservative of high concentration to extend the shelf life, and this is to the lip of child, digestion
Road, hands skin have injury.The advantage of oil preparation is the most dry, and bitterness is difficult to be worn away；But shortcoming is to be coated with
Fingernail, it is impossible to Tu Shoupi, some child's fingernail all stung, and oil preparation is without basing oneself upon.It addition, in oil preparation
Containing harmful substances such as benzene, acetone, formaldehyde, the nail matrix of child and whole body can be caused damage.
Summary of the invention
The invention provides a kind of bitterness aversive agent and preparation method thereof.
The invention provides following scheme:
A kind of bitterness aversive agent, including the raw material of following weight portion:
Bitter substance carrier 490～510 parts, bitter substance 0.042～0.046 part and additive 4.5～
5.5 part；
Wherein, described bitter substance carrier is aloe stoste, described bitter substance be denatonium benzoate with
The saturated solution that water is in harmonious proportion according to 1: 1000 ratio, described additive include sodium hydroxide solution, chrondroitin,
Carbomer and Flos Matricariae chamomillae hydrosol.
Preferred: described additive includes chrondroitin 1.4～1.6 parts.
A kind of preparation method of bitterness aversive agent, described method includes:
Select the fresh aloe leaf of 5～7 years leaf ages, clean after surface smut, cut open and remove the peel and take mesophyll；With
Clear water rinses out described mesophyll outer layer milky mucus, places into immersion 29～31 minutes in clear water, then
Pick up and drench solid carbon dioxide and divide；The mesophyll that pouring solid carbon dioxide divides is cut into small pieces, puts into pulverizer and pulverize, by powder
Mesophyll after broken carries out filtering acquisition and carries frothy aloe stoste, is scraped by the foam above described aloe stoste
Go out and the foam scraped and aloe stoste are respectively placed in containers for future use；
With sodium hydroxide solution, the pH value scraping the aloe stoste defoamed is adjusted to 7, adds chrondroitin, use
The watering can of high precision sprays into the saturated solution that denatonium benzoate is in harmonious proportion according to 1: 1000 ratio with water,
And add carbomer and Flos Matricariae chamomillae hydrosol；It is stirred with Glass rod, and scrapes, described in observation, the reed defoamed
The density of luxuriant growth stock solution, until described Glass rod is mentioned, described in scrape the aloe stoste defoamed not to dirty
Stirring is stopped time dynamic；
Aloe stoste after stirring is put into blender after described foams mix, at a slow speed agitation 38～42
Minute, both described bitterness aversive agent.
Preferred: described fresh aloe leaf is fresh Aloe Barbadensis Miller or fresh upper agricultural university leaf Folium Aloe.
Preferred: by standby for the bottling of described bitterness aversive agent.
Preferred: addition chrondroitin 1.4～1.6 parts.
The specific embodiment provided according to the present invention, the invention discloses techniques below effect:
By the invention it is possible to realize a kind of bitterness aversive agent and preparation method thereof, under a kind of implementation,
This aversive agent can include bitter substance carrier, bitter substance and additive；Wherein, described bitter substance
Carrier is aloe stoste, and described bitter substance is that denatonium benzoate is in harmonious proportion according to 1: 1000 this example with water
Saturated solution, described additive includes sodium hydroxide solution, chrondroitin, carbomer and Flos Matricariae chamomillae hydrosol.
Bitterness aversive agent that the application provides and preparation method thereof, utilizes fresh aloe stock solution as the load of bitter substance
Body, joins a small amount of chrondroitin, and bitter substance, under the assistance of Aloe and chrondroitin both materials, can be easy to
Ground penetrates into fingernail and subcutaneous tissue, is coated with latter 5 minutes and washes one's hands, and bitterness is the most strongly.This aversive agent is coated with to be used
Convenient, both can be coated with fingernail, and skin can be coated with again, be not afraid of washing, not be afraid of abrasion, preservative free, nontoxic, nothing
Evil, the sensitizer such as calcium oxalate in Folium Aloe, rheum emodin has effectively been removed, very in manufacturing process
It is suitable for children to use.Aloe composition and chrondroitin, also can repair the collagen tissue in nail matrix and skin,
Promote that nail matrix growth and hands skin are repaired.
Certainly, the arbitrary product implementing the present invention it is not absolutely required to reach all the above excellent simultaneously
Point.
Detailed description of the invention
Below the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described
Embodiment be only a part of embodiment of the present invention rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained, broadly fall into present invention protection
Scope.
Fingernail biting, gnaw hands skin, finger sucking, the Deviant Behavior such as bite one's lips, subordination mental behavior disorder, also known as
Behavior addiction.But not every Deviant Behavior person is behavior addiction, makes a definite diagnosis this disease and must possess following three
Index: 1, Deviant Behavior reaches more than 2 years；2, cannot correct by self will power；3, there is local lesion,
As nail matrix shortens, finger deforms, or skin injury, ability to speak deformity etc..
Within two years old, child stings hands and belongs to normal behaviour, need not rescue；2-5 year child has fingernail biting, eats hands
Refer to, gnaw the behaviors such as hands skin, though being also not really is behavior addiction, but preferably rescue as early as possible preferably, if delaying,
Likely can develop into behavior addiction；The child of this age bracket is also easiest to rescue.Age is the biggest, rescues more
Difficult.
The bitterness aversive agent that the application provides has two kinds of primary efficacy, and one is to utilize its extremely bitter taste,
It is coated on fingernail or skin, allows the sensory system of people that bitterness and fingernail are combined, promotes sensory system
Fingernail is produced aversion, forms new trained reflex, reach hands mouth and separate, cut off behavior automatization chain
Purpose；Two is containing chrondroitin and the Aloe factor in this bitterness aversive agent, can rapidly promote nail matrix and skin
Growth and reparation.
The bitterness aversive agent that the application provides has abandoned traditional use water or oil preparation as bitter substance
Carrier, uses aloe stoste as bitter substance carrier, it is not necessary to add any preservative, facilitate user to be coated with
Smear.100% consummate aloe stoste contains the Aloe factor, simultaneously rich in the whitening skin and preserving moisture factor, deeply nourishes flesh
Skin, improves the obscure colour of skin, persistently keeps the skin that pale water is tender, have concurrently simultaneously inhibiting bacteria and diminishing inflammation, toxin expelling skin protection,
Control oil presses down the effects such as fat.Life-time service, can effective delaying skin aging, improve allergy skin quality, improve skin
Immunity, maintains skin health brilliant white elegance.Also containing abundant trace mineral element, skin can be repaired because of U.S.
In vain, speckle dispelling, change functional damage and sequela that skin causes, reappear healthy skin；It is applied to hand, can make
Hand skin is the finest and the smoothest, bright and clean, allows you have the fine and slim hands that a pair of is charming.
Effect to the other several raw materials used described in the embodiment of the present application is done and is simply introduced below:
Denatonium benzoate: this product is white crystalline powder, fusing point 163～170 DEG C, odorless, have
Bitterness strongly, is highly soluble in water, ethanol, ethylene glycol etc., and its aqueous solution is neutrality.This product is
The most bitter the most known material, just makes people be difficult to stand, in day when concentration in the solution reaches 0.003%
Articles for use and industrial goods are used as bitters (or aversive agent), in being possible to prevent to eat by mistake because of people, animal and cause
The generation of poison event and prevent child from biting article, therefore many national regulations this product is used for article of everyday use and
In the industrial goods such as plastic, rubber toy product.
Chrondroitin: chrondroitin molecular weight is generally 2-5 ten thousand, white powder, has compared with strong absorptive, readily soluble
In water and become viscous solution, insoluble in ethanol, ether, acetone and other organic solvent.Its chemical composition is
D-Glucose aldehydic acid and acetylaminohexose (glucose and galactose) are by 1, and 3-b-glycosidic bond is connected
High polymer.Purposes: chondroitin sulfate, is a kind of acid mucopolysaccharide, for the medicine that clinic is more common, uses
In some nervous headache, neuralgia, arthralgia, migraine, arteriosclerosis etc.；Can also be used for strepto-
The auxiliary treatment of dysacousis that element causes and hepatitis etc..
Carbomer: be to cross-link, with acrylic acid, the acrylic acid crosslinked resin obtained with tetramethylolmethane etc., be that a class is non-
The most important rheology control agent, the card ripple after neutralization is outstanding gel-type vehicle, has thickening, suspension etc. important
Purposes, technique is simple, and good stability is widely used in emulsion, cream, gel.
Flos Matricariae chamomillae hydrosol: the one separated from fresh petal during refining chamomile essential oil
The saturated hydrosol of 100%, molecular weight is few, and composition is natural pure, and fragrance is light pleasant, and Flos Matricariae chamomillae essence
Oil has similar effect.Flos Matricariae chamomillae hydrosol can improve acne, allergy, eczema, burn and scald, can say and is
One of hydrosol optimal to skin, has antiinflammatory and pacifies characteristic, for sensitive and acne vulgaris skin, to dryness,
Sensitive skin is fabulous；Treatment pimples, herpes, eczema, tinea, microvascular there is good effect；
Can be used to the eye skin protecting face most sensitive, notable for treatment acne vulgaris and red seal effect, increase skin
Skin resistance.
The technical scheme provided the application below by specific embodiment is described in detail:
Embodiment 1
The embodiment of the present invention 1 provides a kind of bitterness aversive agent, and this aversive agent includes the former of following weight portion
Material:
Bitter substance carrier 490～510 parts, bitter substance 0.042～0.046 part and additive 4.5～
5.5 part；
Wherein, described bitter substance carrier is aloe stoste, described bitter substance be denatonium benzoate with
The saturated solution that water is in harmonious proportion according to 1: 1000 ratio, described additive include sodium hydroxide solution, chrondroitin,
Carbomer and Flos Matricariae chamomillae hydrosol.In actual applications, described additive includes chrondroitin 1.4～1.6
Part.The denatonium benzoate that the application selects and water are mesh according to the saturated solution that 1: 1000 ratio is in harmonious proportion
The most bitter material of front the known world, consumption the most just can reach the bitterness intensity of needs；And long-term medical treatment is real
In trampling, the saturated solution that discovery denatonium benzoate and water are in harmonious proportion according to 1: 1000 this example on the contrary than with
Plant bitters is safer because denatonium benzoate and water according to 1: 1000 this example be in harmonious proportion saturated molten
Liquid consumption is few, and toxicity is negligible.The bitterness aversive agent that the application provides can be according to patient not the same year
Age, able to endure hardships difference of ability, be provided with two kinds of bitter concentration, standard edition (denatonium benzoate and water according to
The saturated solution content that 1: 1000 ratio is in harmonious proportion: 0.0028%) and extremely bitter version (denatonium benzoate and
The saturated solution content that water is in harmonious proportion according to 1: 1000 this example: 0.0032%), to adapt to the demand of different patient.
Bitter substance in same kind of products at abroad is also bitter.It is understood, however, that in being actually used in, also
Denatonium benzoate can be adjusted according to the able to endure hardships degree of different user to be in harmonious proportion according to 1: 1000 ratio with water
The content of saturated solution, the application does not do concrete restriction.
Embodiment 2
The embodiment of the present invention 1 provides a kind of bitterness aversive agent, and this aversive agent includes the former of following weight portion
Material:
490 grams of bitter substance carrier, bitter substance 0.042 gram and additive 4.5 grams；
Wherein, described bitter substance carrier is aloe stoste, described bitter substance be denatonium benzoate with
The saturated solution that water is in harmonious proportion according to 1: 1000 this example, described additive include sodium hydroxide solution, chrondroitin,
Carbomer and Flos Matricariae chamomillae hydrosol.In actual applications, described additive includes chrondroitin 1.4 grams.
Embodiment 3
The embodiment of the present invention 1 provides a kind of bitterness aversive agent, and this aversive agent includes the former of following weight portion
Material:
500 grams of bitter substance carrier, bitter substance 0.045 gram and additive 5 grams；
Wherein, described bitter substance carrier is aloe stoste, described bitter substance be denatonium benzoate with
The saturated solution that water is in harmonious proportion according to 1: 1000 ratio, described additive include sodium hydroxide solution, chrondroitin,
Carbomer and Flos Matricariae chamomillae hydrosol.In actual applications, described additive includes chrondroitin 1.5 grams.
Embodiment 4
The embodiment of the present invention 1 provides a kind of bitterness aversive agent, and this aversive agent includes the former of following weight portion
Material:
510 grams of bitter substance carrier, bitter substance 0.046 gram and additive 5.5 grams；
Wherein, described bitter substance carrier is aloe stoste, described bitter substance be denatonium benzoate with
The saturated solution that water is in harmonious proportion according to 1: 1000 ratio, described additive include sodium hydroxide solution, chrondroitin,
Carbomer and Flos Matricariae chamomillae hydrosol.In actual applications, described additive includes chrondroitin 1.6 grams.
Embodiment 5
The preparation method of bitterness aversive agent described in a kind of any one of embodiment 1 to 4, described method includes:
Select the fresh aloe leaf of 5～7 years leaf ages, clean after surface smut, cut open and remove the peel and take mesophyll；With
Clear water rinses out described mesophyll outer layer milky mucus, and this white slimy includes sensitizer calcium oxalate, Radix Et Rhizoma Rhei
Elements etc., should remove clean in preparation process as far as possible.Place into immersion 29～31 minutes in clear water, then
Pick up and drench solid carbon dioxide and divide；The mesophyll that pouring solid carbon dioxide divides is cut into small pieces, puts into pulverizer and pulverize, by powder
Mesophyll after broken carries out filtering acquisition and carries frothy aloe stoste, in actual applications, can filtration be obtained
The filtering residue obtained again is poured juice extractor into and is squeezed one to twice, to ensure to squeeze totally by the aloe stoste in raw material,
Avoid causing waste.Foam above described aloe stoste is scraped and by the foam scraped and aloe stoste
It is respectively placed in containers for future use；
With sodium hydroxide solution, the pH value scraping the aloe stoste defoamed is adjusted to 7, add chrondroitin 1.4～
1.6 parts, spray into what denatonium benzoate and water were in harmonious proportion according to 1: 1000 ratio with the watering can of high precision
Saturated solution, and add carbomer and Flos Matricariae chamomillae hydrosol；It is stirred with Glass rod, and scrapes described in observation
The density of the aloe stoste defoamed, until described Glass rod is mentioned, described in scrape the Aloe defoamed former
Stirring is stopped when liquid does not flows downward.
Aloe stoste after stirring is put into blender after described foams mix, at a slow speed agitation 38～42
Minute, stock solution foam now be can be observed and the most all disappear, and intensive tiny bubble occurs in preparation.
Both described bitterness aversive agent.Can add standby for the bottling of described bitterness aversive agent.In a particular application, institute
Stating fresh aloe leaf can be fresh Aloe Barbadensis Miller or fresh upper agricultural university leaf Folium Aloe.
When the using method of the bitterness aversive agent that the application provides and use, points for attention are: first washed by both hands
Only dry, open bottle cap, be stained with seldom some bitterness aversive agents with the brush of small brushes, by light for bitterness aversive agent
Dab is put on fingernail and the hands skin that is snapped.After painting about one minute, fingernail and skin surface were the most dry, such as dried fruits
Overlong time, illustrate to be coated with too much；Bitterness aversive agent consumption is the fewest, be sure not to be coated with full hands is all.Cut not
Small brushes can be injected in bitterness aversive agent, the most not only waste but also easily cause bitterness aversive agent to pollute.If from upper
And take bitterness aversive agent lowerly, bitterness aversive agent is just unlikely to deteriorate.Brush is finished and is placed on clean paper set
In standby (need not clean).Early, middle and late each painting every day once, is coated with three continuously to surrounding.Some child
Sub-noon stays out at kindergarten or school, and noon can not be coated with specifically；In order to ensure from morning to night on finger
There are enough bitterness, can overbrushing be several times continuously before going to school morning.If there being familiar teacher to be the most just coated with in generation at noon
More preferably.Nail groove, first seam to be also coated onto, and this is conducive to nail matrix to grow.Gnaw the child of hands skin, bitterness aversive agent
Range is larger than the skin gnawed, and this is conducive to skin to repair as early as possible.Bite away the child of lip, will
Bitterness aversive agent is applied to below lower lip line；Person is then applied to above upper lip line to sting upper lip.After being coated with bitterness aversive agent,
Child just cannot directly capture food with hands, otherwise grab what just bitter what, cause food waste.
Disposable glove the to be put on when that child having a meal.Had better not wash immediately after being coated with bitterness aversive agent
Hands, have to wash if child be unwilling to coordinate, and also to manage to delay him 5 minutes, and after 5 minutes, bitter principle is
Penetrate into fingernail and skin histology, even if bitterness of washing one's hands runs off the fewest.During being coated with bitterness aversive agent, suitable
Gesture cultivates child's separate good habit of hands mouth, it is desirable to child squares one's shoulders, straight waist, new line, allows finger away from mouth
Bar.The personality of child is developed the most extremely important by the separate habit formation of hands mouth, and behavior and the personality of the mankind are total
Affect each other.Hands mouth is bended over bent back of the body person regardless of, contracting shoulder, and in the course of time, personality inwardly develops；Hands mouth
Separately, chin up and chest out straight waist person, and in the course of time, personality outwards develops.
In a word, bitterness aversive agent that the application provides and preparation method thereof, utilize fresh aloe stock solution as hardship
The carrier of taste material, joins a small amount of chrondroitin, bitter substance under the assistance of Aloe and chrondroitin both materials,
Can penetrate into fingernail and subcutaneous tissue easily, be coated with latter 5 minutes and wash one's hands, bitterness is the most strongly.This is detested
Dislike agent paintings to facilitate, both can be coated with fingernail, and skin can be coated with again, be not afraid of washing, and not be afraid of abrasion, preservative free,
Nontoxic, harmless, the sensitizer such as calcium oxalate in Folium Aloe, rheum emodin is the most clear in manufacturing process
Remove, be especially suitable for children and use.Aloe composition and chrondroitin, also can repair the glue in nail matrix and skin
Basic stitch, promotes that nail matrix growth and hands skin are repaired.
It should be noted that in this article, the relational terms of such as first and second or the like be used merely to by
One entity or operation separate with another entity or operating space, and not necessarily require or imply these
Relation or the order of any this reality is there is between entity or operation.And, term " includes ", " bag
Contain " or its any other variant be intended to comprising of nonexcludability, so that include a series of key element
Process, method, article or equipment not only include those key elements, but also include being not expressly set out
Other key elements, or also include the key element intrinsic for this process, method, article or equipment.?
In the case of there is no more restriction, statement " including ... " key element limited, it is not excluded that at bag
Include and the process of described key element, method, article or equipment there is also other identical element.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the protection model of the present invention
Enclose.All any modification, equivalent substitution and improvement etc. made within the spirit and principles in the present invention, all wrap
Containing within the scope of the present invention.
Claims (6)
1. a bitterness aversive agent, it is characterised in that described aversive agent includes the raw material of following weight portion:
Bitter substance carrier 490～510 parts, bitter substance 0.042～0.046 part and additive 4.5～
5.5 part；
Wherein, described bitter substance carrier is aloe stoste, described bitter substance be denatonium benzoate with
The saturated solution that water is in harmonious proportion according to 1: 1000 ratio, described additive include sodium hydroxide solution, chrondroitin,
Carbomer and Flos Matricariae chamomillae hydrosol.
Bitterness aversive agent the most according to claim 1, it is characterised in that described additive includes
Chrondroitin 1.4～1.6 parts.
3. the preparation method of bitterness aversive agent described in an any one of claim 1 to 2, it is characterised in that
Described method includes:
Select the fresh aloe leaf of 5～7 years leaf ages, clean after surface smut, cut open and remove the peel and take mesophyll；With
Clear water rinses out described mesophyll outer layer milky mucus, places into immersion 29～31 minutes in clear water, then
Pick up and drench solid carbon dioxide and divide；The mesophyll that pouring solid carbon dioxide divides is cut into small pieces, puts into pulverizer and pulverize, by powder
Mesophyll after broken carries out filtering acquisition and carries frothy aloe stoste, is scraped by the foam above described aloe stoste
Go out and the foam scraped and aloe stoste are respectively placed in containers for future use；
With sodium hydroxide solution, the pH value scraping the aloe stoste defoamed is adjusted to 7, adds chrondroitin, use
The watering can of high precision sprays into the saturated solution that denatonium benzoate is in harmonious proportion according to 1: 1000 ratio with water,
And add carbomer and Flos Matricariae chamomillae hydrosol；It is stirred with Glass rod, and scrapes, described in observation, the reed defoamed
The density of luxuriant growth stock solution, until described Glass rod is mentioned, described in scrape the aloe stoste defoamed not to dirty
Stirring is stopped time dynamic；
Aloe stoste after stirring is put into blender after described foams mix, at a slow speed agitation 38～42
Minute, both described bitterness aversive agent.
Method the most according to claim 3, it is characterised in that described fresh aloe leaf is fresh storehouse
Drag-line Folium Aloe or fresh upper agricultural university leaf Folium Aloe.
Method the most according to claim 3, it is characterised in that by standby for the bottling of described bitterness aversive agent
With.
Method the most according to claim 3, it is characterised in that addition chrondroitin 1.4～1.6 parts.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610370181.6A CN105998544A (en) | 2016-05-31 | 2016-05-31 | Bitter aversive agent and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610370181.6A CN105998544A (en) | 2016-05-31 | 2016-05-31 | Bitter aversive agent and preparation method thereof |
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| CN105998544A true CN105998544A (en) | 2016-10-12 |
Family
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110038010A (en) * | 2019-04-28 | 2019-07-23 | 瑞雅科医药(北京)有限公司 | A kind of bitter taste detests preparation and preparation method thereof and bite preventing pen |
| CN110051556A (en) * | 2019-05-24 | 2019-07-26 | 刘小立 | A kind of liniment and its manufacturing method for protecting nail |
| WO2019236807A1 (en) * | 2018-06-06 | 2019-12-12 | Tacconelli Mark | Method and kit for providing a customizable nail-biting finger-sucking prevention treatment |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101583717A (en) * | 2006-11-01 | 2009-11-18 | 塞诺米克斯公司 | Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators |
| CN102196744A (en) * | 2008-08-21 | 2011-09-21 | 克里斯汀·斯威尔克 | Nail restoration device that prevents nail biting |
| CN103110566A (en) * | 2013-01-31 | 2013-05-22 | 巫国谊 | External pigmentum for correcting bad habit of finger sucking of infants |
| CN103463333A (en) * | 2013-09-27 | 2013-12-25 | 四川农业大学 | Aloe-cactus-peach leaf gel preparation and preparation method thereof |
| CN103751081A (en) * | 2014-01-26 | 2014-04-30 | 广东景兴卫生用品有限公司 | Natural anti-acne conditioner and preparation process thereof |
| CN104321064A (en) * | 2012-05-23 | 2015-01-28 | 阿尔特刚股份有限公司 | Chondroitin for use in medicine |
-
2016
- 2016-05-31 CN CN201610370181.6A patent/CN105998544A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101583717A (en) * | 2006-11-01 | 2009-11-18 | 塞诺米克斯公司 | Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators |
| CN102196744A (en) * | 2008-08-21 | 2011-09-21 | 克里斯汀·斯威尔克 | Nail restoration device that prevents nail biting |
| CN104321064A (en) * | 2012-05-23 | 2015-01-28 | 阿尔特刚股份有限公司 | Chondroitin for use in medicine |
| CN103110566A (en) * | 2013-01-31 | 2013-05-22 | 巫国谊 | External pigmentum for correcting bad habit of finger sucking of infants |
| CN103463333A (en) * | 2013-09-27 | 2013-12-25 | 四川农业大学 | Aloe-cactus-peach leaf gel preparation and preparation method thereof |
| CN103751081A (en) * | 2014-01-26 | 2014-04-30 | 广东景兴卫生用品有限公司 | Natural anti-acne conditioner and preparation process thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019236807A1 (en) * | 2018-06-06 | 2019-12-12 | Tacconelli Mark | Method and kit for providing a customizable nail-biting finger-sucking prevention treatment |
| CN112533576A (en) * | 2018-06-06 | 2021-03-19 | 马克·塔科内利 | Methods and kits for providing customizable onychomycosis prophylaxis treatment |
| JP2021527124A (en) * | 2018-06-06 | 2021-10-11 | タッコネリー，マーク | Methods and kits for providing customizable nail bite finger sucking precautions |
| US11529327B2 (en) * | 2018-06-06 | 2022-12-20 | Mark Tacconelli | Method and kit for providing a customizable nail-biting finger-sucking prevention treatment |
| CN112533576B (en) * | 2018-06-06 | 2023-06-16 | 马克·塔科内利 | Customizable nail-biting treatment and finger sucking kit |
| CN110038010A (en) * | 2019-04-28 | 2019-07-23 | 瑞雅科医药(北京)有限公司 | A kind of bitter taste detests preparation and preparation method thereof and bite preventing pen |
| CN110051556A (en) * | 2019-05-24 | 2019-07-26 | 刘小立 | A kind of liniment and its manufacturing method for protecting nail |
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