CN105998454A - Traditional Chinese medicine composition for treating infantile diarrhea and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating infantile diarrhea and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/06—Fungi, e.g. yeasts
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Abstract
The invention belongs to the technical field of Chinese herba preparation, in particular relates to a traditional Chinese medicine composition for treating infantile diarrhea, and further discloses a preparation method thereof. The traditional Chinese medicine composition for treating infantile diarrhea provided by the invention is prepared from the following crude drugs: fructus piperis alba, poria cocos, the fruit of Chinese magnoliavine, fruit of immature citron, herba houttuyniae, fructus psoraleae, the root of kudzu vine, rhizoma corydalis, frankincense, rhizoma alismatis, honeysuckle stem, fructus citrus sarcodactylis and chastetree fruit. The crude drugs are combined to achieve the effect, so that the traditional Chinese medicine composition for treating infantile diarrhea has higher effective rate on treating infantile diarrhea, is effective in treatment of bacterial diarrhea, viral diarrhea, non-infectious diarrhea and other infantile diarrhea, does not need expensive recovery cost, and is shorter in treatment cycle and convenient to popularize clinically in large scale.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine treating infantile diarrhea
Compositions, and its preparation method is disclosed further.
Background technology
Infantile diarrhea be a kind of by many cause of diseases, multifactor cause increase with times of defecation and stool
Change into the digestive tract syndrome of feature, and can with generating heat, vomit, symptom and the different journey such as stomachache
The water of degree, electrolyte, acid base imbalance, be also one of disease that Childhood sickness rate is the highest,
It is worldwide public health problem, is one of modal disease of China juvenile.According to world health group
Knitting investigation, suffering from diarrhoea in about annual at least 10 hundred million person-times of the whole world, dies from the child of diarrhoea every year especially
Up to 5,000,000-1,800 ten thousand, every day about 10,000, people died from diarrhoea.In China, infantile diarrhea is to be only second to
2nd commonly encountered diseases of respiratory tract infection, the annual morbidity of less than 5 years old Children's diarrhea vein of China is 201%,
The most each child's year falls ill 3.5 times, and its mortality rate is 0.51%, therefore, to Children's diarrhea vein
Prevent and treat particularly significant.
Children's diarrhea vein can be divided into according to the course of disease: children with acute diarrheal disease, and its course of disease is within 2 weeks；Delay
Property diarrhoeal diseases, the course of disease was at 2 weeks-2 months；Chronic diarrheal disease (, the course of disease is more than 2 months.According to the state of an illness
Degree can be divided into: light-duty diarrhoea, general without dehydration, without poisoning symptom；Medium-sized diarrhoea, occurs light
Degree is to moderate dehydration or has poisoning symptom；Heavy diarrhoea, with severe dehydration or there is obvious poisoning symptom
(agitation, lethargy, drowsiness, pale complexion, Gao Re or body temperature does not rises, numeration of leukocyte is obvious
Increase).Then can be divided into according to the cause of disease: infectious diarrhea, such as dysentery, cholera, other infectivities
Diarrhoea etc.；Noninfectious diarrhea, including bait (Diet) diarrhoea situation；Symptomatic diarrhea,
Such as symptoms such as allergic diarrheas；Other diarrhoeal diseasess, such as lactose intolerance, glucogen diarrhoea etc..Wherein,
Infectious diarrhea be Children's diarrhea vein commonly encountered diseases because of, infectious diarrhea is further subdivided into viral
Enteritis and bacterial enteritis etc..The type of infantile diarrhea disease is different, and its pathogenesis is the most otherwise varied:
The pathogenesis of viral enteritis be on the whole due to various Virus entry intestinals after, make intestinal villi
Top columnar epithelial cell degeneration necrosis, the ability causing small intestinal mucosa resorption to receive moisture and electrolyte is subject to
Damaging, intestinal juice causes diarrhoea in enteric cavity inner accumulated；Bacterial enteritis mainly by Escherichia coli,
Enterotoxigenic E．Coli, Enterohemorrhagic E.coli, enteroinvasive E．Coli and Salmonella typhimurium,
Intestinal pathological changes caused after the bacterial invasion intestinals such as campylobacter jejuni, yersinia enterocolitica, S. aureus L-forms, invasion
Antibacterial difference cause its pathogenesis different.And noninfectious diarrhea is mainly caused by improper diet,
The digestion process generation obstacle when excessive eating or composition of food are incorrect, food stagnates at upper part of small intestine,
In making enteric cavity, acidity reduces, and beneficially moves and breeds on the antibacterial of lower intestine；Fermented foodstuff and corruption,
Decomposing osmotic pressure in the short chain organic acid produced makes enteric cavity to increase, corruptibility toxic product stimulates intestinal wall to make
Enterokinesia increase causes diarrhoea.
The patient of general bacillary infantile diarrhea typically requires the susceptibility situation according to antibacterial, by rationally
Ground selects antibiotics to treat, but there is abuse of antibiotics and drug-fast potential hazard also.
The more important thing is, account for viral enteritis and the noninfectious diarrhea of most of ratios in infantile diarrhea at present
Treatment, it uses medicine the most limited, and therapeutic effect inconspicuous.
Summary of the invention
To this end, the technical problem to be solved is that offer one can complete treatment infantile diarrhea
Chinese medicine composition, and its preparation method is disclosed further.
For solving above-mentioned technical problem, the Chinese medicine composition for the treatment of infantile diarrhea of the present invention, its
Crude drug composition includes: Radix orixae japonicae 40-80 weight portion, Poria 30-60 weight portion, Fructus Schisandrae Chinensis 40-70
Weight portion, Fructus Aurantii Immaturus 20-40 weight portion, Herba Houttuyniae 15-35 weight portion, Fructus Psoraleae 15-25 weight portion,
Radix Puerariae 20-30 weight portion, Rhizoma Corydalis 8-15 weight portion, Olibanum 10-20 weight portion, Rhizoma Alismatis 6-15 weight
Amount part, Caulis Lonicerae 4-10 weight portion, Fructus Citri Sarcodactylis 3-9 weight portion, Fructus Viticis 5-10 weight portion.
Preferably, the crude drug composition of described compositions includes: Radix orixae japonicae 60 weight portion, Poria 45
Weight portion, Fructus Schisandrae Chinensis 55 weight portion, Fructus Aurantii Immaturus 30 weight portion, Herba Houttuyniae 25 weight portion, Fructus Psoraleae 20
Weight portion, Radix Puerariae 25 weight portion, Rhizoma Corydalis 12 weight portion, Olibanum 15 weight portion, Rhizoma Alismatis 10 weight
Amount part, Caulis Lonicerae 7 weight portion, Fructus Citri Sarcodactylis 6 weight portion, Fructus Viticis 8 weight portion.
Described Chinese medicine composition adds customary adjuvant, makes the most acceptable dose according to common process
Type.
The invention also discloses by described Chinese medicine composition, add customary adjuvant, according to common process
Make the external preparation of the most acceptable treatment infantile diarrhea.
Described preparation includes patch or unguentum.
The invention also discloses a kind of method preparing described Chinese medicine composition, including according to selected
Parts by weight take described Radix orixae japonicae, Poria, Fructus Schisandrae Chinensis, Fructus Aurantii Immaturus, Herba Houttuyniae, Fructus Psoraleae, Radix Puerariae,
Rhizoma Corydalis, Olibanum, Rhizoma Alismatis, Caulis Lonicerae, Fructus Citri Sarcodactylis and Fructus Viticis, mix after pulverizing or pulverizing after mixing
Step, and according to common process, add customary adjuvant, make the most acceptable dosage form.
Concrete, the described method preparing described Chinese medicine composition, comprise the steps:
(1) described Radix orixae japonicae, Poria, Fructus Aurantii Immaturus, Fructus Psoraleae, Rhizoma Corydalis are taken according to selected parts by weight
Rope, Olibanum and Caulis Lonicerae mixing, collect decoction liquor, obtain Aqueous extracts after boiling, standby；
(2) described Fructus Schisandrae Chinensis, Herba Houttuyniae, Radix Puerariae, Rhizoma Alismatis, Fructus Citri Sarcodactylis are taken according to selected parts by weight
Mix with Fructus Viticis, add ethanol solution and carry out extract at room temperature, obtain alcohol extract, standby；
(3) described Aqueous extracts and alcohol extract are collected, and according to common process, interpolation customary adjuvant, system
Become the most acceptable dosage form.
More excellent, the described method preparing described Chinese medicine composition, comprise the steps:
(1) described Radix orixae japonicae, Poria, Fructus Aurantii Immaturus, Fructus Psoraleae, Rhizoma Corydalis are taken according to selected parts by weight
Rope, Olibanum and Caulis Lonicerae mixing, the water adding drug weight 2-4 weight times amount carries out decocting 1-3 time,
And collect decoction liquor, and obtain Aqueous extracts, standby；
(2) described Fructus Schisandrae Chinensis, Herba Houttuyniae, Radix Puerariae, Rhizoma Alismatis, Fructus Citri Sarcodactylis are taken according to selected parts by weight
Mix with Fructus Viticis, add the ethanol that mass concentration is 50-70wt% of drug weight 1-3 weight times amount
Solution carries out extract at room temperature 1-3 time, obtains alcohol extract, standby；
(3) described Aqueous extracts and alcohol extract are collected, and according to common process, interpolation customary adjuvant, system
Become the most acceptable dosage form.
The invention also discloses described Chinese medicine composition for preparing the purposes for the treatment of infantile diarrhea medicine.
Described infantile diarrhea includes bacillary infantile diarrhea, viral infantile diarrhea and non-infectious
Diarrhoea.
The Chinese medicine composition for the treatment of infantile diarrhea of the present invention, with Radix orixae japonicae, Poria, Fructus Schisandrae Chinensis,
Fructus Aurantii Immaturus, Herba Houttuyniae, Fructus Psoraleae, Radix Puerariae, Rhizoma Corydalis, Olibanum, Rhizoma Alismatis, Caulis Lonicerae, Fructus Citri Sarcodactylis and climing
Fructus Vitics Simplicifoliae is that crude drug is prepared, wherein,
Radix orixae japonicae, nature and flavor are pungent, warm, have effect of warming spleen and stomach for dispelling cold, the therapeutic method to keep the adverse QI flowing downwards, expectorant, its cold expelling,
Stomach strengthening function is higher；
Poria, sweet in the mouth, property is light, flat, enters the heart, lung, spleen channel；There is eliminating dampness and diuresis,Spleen invigoratingStomach function regulating,
Effect of mind tranquilizing and the heart calming；Cure mainly dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, let out
Rush down, pass out semen, stranguria with turbid discharge, palpitation with fear, the disease such as forgetful；
Fructus Schisandrae Chinensis, warm in nature, sour in the mouth, sweet, return lung, the heart, kidney channel；Have and restrain astringent or styptic treatment for spontaneous sweating, QI invigorating life
Tianjin, effect of kidney calming；Cure mainly that the deficiency of the lung is breathed with cough, xerostomia makees thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation,
Emission, the disease of chronic diarrhea chronic dysentery；
Fructus Aurantii Immaturus, bitter in the mouth, pungent, cold in nature, return spleen, stomach, liver, heart channel；Cure mainly stagnant in stop, feeling of fullness
The disease such as weight, blocked-up chest, gastroptosis, uterine prolapse, proctoptosis after distending pain, constipation, dysentery；
Herba Houttuyniae, cold nature, bitter in the mouth, return lung meridian, bladder, large intestine channel；There is heat-clearing and toxic substances removing, row
Pus eliminating carbuncle, effect of inducing diuresis for treating stranguria syndrome；Cure mainly lung abscess vomiting pus, expectorant dyspnea of heat type is coughed, larynx Oh, hematodiarrhoea, carbuncle
The disease such as sore, pyretic stranguria；
Fructus Psoraleae, acrid in the mouth, hardship, warm in nature, return kidney, pericardium, spleen, stomach, lung meridian；There is the kidney invigorating help
Sun, helping inspiration to relieve asthma, warming spleen and stopping diarrha effect；Cure mainly insufficiency of kidney-YANG, below element deficiency and cold, chills and pain of the waist and kness,
Impotence and seminal emission, frequent micturition, the enuresis, failure of the kidney in receiving QI, dyspnea due to deficiency be more than,Asthenia of both the spleen and kidney, the stool disease such as chronic diarrhea；
Radix Puerariae, cool in nature, sweet in the mouth, pungent；Having induces sweat brings down a fever, promote the production of body fluid, rash, the merit of yang invigorating antidiarrheal
Effect；For fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst,MeaslesImpermeable, hematodiarrhoea,
The treatment of disease such as have loose bowels；
Rhizoma Corydalis, acrid in the mouth, hardship, warm in nature, nontoxic, return liver, stomach, the heart, lung, spleen channel；There is work
Blood, dissipating blood stasis, regulate the flow of vital energy, effect of pain relieving；Cure mainly trusted subordinate's all pains of waist knee joint, menoxenia, lump in the abdomen, collapse
In, the disease such as puerperal blood faints, lochiorrhea, traumatic injury；
Olibanum, acrid in the mouth, hardship, warm in nature, enter the heart, liver, spleen channel；There is regulating qi and activating blood, analgesic therapy, chase after
Effect of poison；Cure mainly coagulation of QI-blood, trusted subordinate's pain, ulcerative carbuncle toxic swelling, traumatic injury, dysmenorrhea, puerperal
The diseases such as blood stasis twinge；
Rhizoma Alismatis, sweet in the mouth, light, cold in nature, return kidney, bladder warp；Have promoting diuresis to eliminate damp pathogen, expel the heat-evil treating stranguria it
Effect；The puckery pain of main dysuria, pyretic stranguria, edema distension, have loose bowels, dizziness due to fluid-retention, seminal emission；
Caulis Lonicerae, sweet in the mouth, hardship, cold nature, return lung,Stomach warp；HaveHeat-clearing and toxic substances removing, dispelling wind dredging collateral
Effect；For epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, redness and swelling of joints burning pain
Treatment Deng disease；
Fructus Citri Sarcodactylis, acrid in the mouth, hardship, sweet, warm in nature, nontoxic, enter liver, spleen, stomach three warp；There is regulating the flow of vital energy
The multiple medicinal efficacies such as expectorant, preventing or arresting vomiting relieving distension, the liver soothing and the spleen invigorating, stomach function regulating；To old people'sTracheitis, roar
Breathe heavily disease and have obvious mitigation；Dyspepsia, chest and abdomen feeling of distension and oppression to common people, has significantly more
Curative effect；
Fructus Viticis, acrid in the mouth, hardship, cold nature, return bladder, liver, stomach warp；There is dispelling wind and heat pathogens, clear
Effect of the profit head；ForAnemopyretic coldHeadache, gingivitis, the many tear of conjunctival congestion, poor vision, head
Dizzy dizzy treatment.
Pharmaceutical composition of the present invention utilizes monarch, minister between above-mentioned raw materials medicine component, help, be allowed between
Cooperation, regard as monarch drug with Radix orixae japonicae, Poria, Fructus Schisandrae Chinensis, play its eliminating dampness and diuresis,Spleen invigoratingStomach function regulating,
Effect of mind tranquilizing and the heart calming；With Fructus Aurantii Immaturus, Herba Houttuyniae, Fructus Psoraleae, Radix Puerariae as ministerial drug；With Rhizoma Corydalis, breast
Fragrant, Rhizoma Alismatis is adjuvant drug, with Caulis Lonicerae, Fructus Citri Sarcodactylis and Fructus Viticis for making medicine；Before each crude drug concurrence its
Effect, the treatment to infantile diarrhea has higher effective percentage, for bacillary infantile diarrhea, viral
The treatment of infantile diarrhea and noninfectious diarrhea all has preferable cure rate, and its clinical cure rate is high
Reach more than 98%, and without expensive restoration costs, treatment cycle is shorter, it is simple to clinical large area pushes away
Wide application.
Detailed description of the invention
Embodiment 1 navel patch
The navel patch of the treatment infantile diarrhea described in the present embodiment, its crude drug composition includes: Radix orixae japonicae
40 weight portions, Poria 60 weight portion, Fructus Schisandrae Chinensis 40 weight portion, Fructus Aurantii Immaturus 40 weight portion, Herba Houttuyniae
15 weight portions, Fructus Psoraleae 25 weight portion, Radix Puerariae 20 weight portion, Rhizoma Corydalis 15 weight portion, Olibanum
10 weight portions, Rhizoma Alismatis 15 weight portion, Caulis Lonicerae 4 weight portion, Fructus Citri Sarcodactylis 9 weight portion g, Fructus Viticis 5
Weight portion.
The navel patch of the treatment infantile diarrhea described in the present embodiment is prepared as follows:
(1) described Radix orixae japonicae, Poria, Fructus Aurantii Immaturus, Fructus Psoraleae, Rhizoma Corydalis are taken according to selected parts by weight
Rope, Olibanum and Caulis Lonicerae mixing, the water adding drug weight 2 weight times amount carries out decocting 3 times, and
Collect decoction liquor, obtain Aqueous extracts, standby；
(2) described Fructus Schisandrae Chinensis, Herba Houttuyniae, Radix Puerariae, Rhizoma Alismatis, Fructus Citri Sarcodactylis are taken according to selected parts by weight
Mix with Fructus Viticis, add the ethanol solution that mass concentration is 70wt% of drug weight 1 weight times amount
Carry out extract at room temperature 3 times, obtain alcohol extract, standby；
(3) described Aqueous extracts and alcohol extract are collected, and according to common process, interpolation customary adjuvant, system
Become navel patch.
Embodiment 2 ointment
The ointment of the treatment infantile diarrhea described in the present embodiment, its crude drug composition includes: Radix orixae japonicae
80kg, Poria 30kg, Fructus Schisandrae Chinensis 70kg, Fructus Aurantii Immaturus 20kg, Herba Houttuyniae 35kg, Fructus Psoraleae 15kg,
Radix Puerariae 30kg, Rhizoma Corydalis 8kg, Olibanum 20kg, Rhizoma Alismatis 6kg, Caulis Lonicerae 10kg, Fructus Citri Sarcodactylis 3kg,
Fructus Viticis 10kg.
The ointment of the treatment infantile diarrhea described in the present embodiment is prepared as follows:
(1) described Radix orixae japonicae, Poria, Fructus Aurantii Immaturus, Fructus Psoraleae, Rhizoma Corydalis are taken according to selected parts by weight
Rope, Olibanum and Caulis Lonicerae mixing, the water adding drug weight 4 weight times amount carries out decocting 1 time, and
Collect decoction liquor, obtain Aqueous extracts, standby；
(2) described Fructus Schisandrae Chinensis, Herba Houttuyniae, Radix Puerariae, Rhizoma Alismatis, Fructus Citri Sarcodactylis are taken according to selected parts by weight
Mix with Fructus Viticis, add the ethanol solution that mass concentration is 50wt% of drug weight 3 weight times amount
Carry out extract at room temperature 1 time, obtain alcohol extract, standby；
(3) described Aqueous extracts and alcohol extract are collected, and according to common process, interpolation customary adjuvant, system
Become the most acceptable dosage form.
Embodiment 3 navel patch
The navel patch of the treatment infantile diarrhea described in the present embodiment, its crude drug composition includes: Radix orixae japonicae
60kg, Poria 45kg, Fructus Schisandrae Chinensis 55kg, Fructus Aurantii Immaturus 30kg, Herba Houttuyniae 25kg, Fructus Psoraleae 20kg,
Radix Puerariae 25kg, Rhizoma Corydalis 12kg, Olibanum 15kg, Rhizoma Alismatis 10kg, Caulis Lonicerae 7kg, Fructus Citri Sarcodactylis 6kg,
Fructus Viticis 8kg.
The navel patch of the treatment infantile diarrhea described in the present embodiment is prepared as follows:
(1) described Radix orixae japonicae, Poria, Fructus Aurantii Immaturus, Fructus Psoraleae, Rhizoma Corydalis are taken according to selected parts by weight
Rope, Olibanum and Caulis Lonicerae mixing, the water adding drug weight 3 weight times amount carries out decocting 2 times, and
Collect decoction liquor, obtain Aqueous extracts, standby；
(2) described Fructus Schisandrae Chinensis, Herba Houttuyniae, Radix Puerariae, Rhizoma Alismatis, Fructus Citri Sarcodactylis are taken according to selected parts by weight
Mix with Fructus Viticis, add the ethanol solution that mass concentration is 60wt% of drug weight 2 weight times amount
Carry out extract at room temperature 2 times, obtain alcohol extract, standby；
(3) described Aqueous extracts and alcohol extract are collected, and according to common process, interpolation customary adjuvant, system
Become navel patch.
Embodiment 4 patch
The patch of the treatment infantile diarrhea described in the present embodiment, its crude drug composition includes: Radix orixae japonicae 50kg,
Poria 52kg, Fructus Schisandrae Chinensis 48kg, Fructus Aurantii Immaturus 35kg, Herba Houttuyniae 20kg, Fructus Psoraleae 22kg, Radix Puerariae 22kg,
Rhizoma Corydalis 13kg, Olibanum 12kg, Rhizoma Alismatis 12kg, Caulis Lonicerae 5kg, Fructus Citri Sarcodactylis 8kg, Fructus Viticis 6kg.
The patch of the treatment infantile diarrhea described in the present embodiment is prepared as follows: according to selected
Parts by weight take described Radix orixae japonicae, Poria, Fructus Schisandrae Chinensis, Fructus Aurantii Immaturus, Herba Houttuyniae, Fructus Psoraleae, Radix Puerariae,
Rhizoma Corydalis, Olibanum, Rhizoma Alismatis, Caulis Lonicerae, Fructus Citri Sarcodactylis and Fructus Viticis, mix after pulverizing or pulverizing after mixing
Step, and according to common process, add customary adjuvant, make the most acceptable patch.
Embodiment 5 navel patch
The navel patch of the treatment infantile diarrhea described in the present embodiment, its crude drug composition includes: Radix orixae japonicae
70kg, Poria 38kg, Fructus Schisandrae Chinensis 62kg, Fructus Aurantii Immaturus 25kg, Herba Houttuyniae 30kg, Fructus Psoraleae 18kg,
Radix Puerariae 27kg, Rhizoma Corydalis 10kg, Olibanum 18kg, Rhizoma Alismatis 8kg, Caulis Lonicerae 8kg, Fructus Citri Sarcodactylis 5kg,
Fructus Viticis 9kg.
The navel patch of the treatment infantile diarrhea described in the present embodiment is prepared as follows:
(1) described Radix orixae japonicae, Poria, Fructus Aurantii Immaturus, Fructus Psoraleae, Rhizoma Corydalis are taken according to selected parts by weight
Rope, Olibanum and Caulis Lonicerae mixing, collect decoction liquor, obtain Aqueous extracts after boiling, standby；
(2) described Fructus Schisandrae Chinensis, Herba Houttuyniae, Radix Puerariae, Rhizoma Alismatis, Fructus Citri Sarcodactylis are taken according to selected parts by weight
Mix with Fructus Viticis, add ethanol solution and carry out extract at room temperature, obtain alcohol extract, standby；
(3) described Aqueous extracts and alcohol extract are collected, and according to common process, interpolation customary adjuvant, system
Become the most acceptable navel patch.
Experimental example
Using the navel patch prepared by the embodiment of the present invention 3 to carry out clinical treatment experiment, screening suffers from little
Infant 280 example of youngster's symptom of diarrhea, patient is 1-6 year children's/child, wherein boy 152 example,
Young girl 128 example.
In above-mentioned 280 pediatric patients being diagnosed as infantile diarrhea, all suffer from diarrhoea in various degree
Symptom, and with dewatering symptom in various degree, appetite is poor, and the persistent period is 1 week to 1 month
?.In the clinical diagnosis of the indexs such as blood count, infant, it is diagnosed as the trouble of bacillary infantile diarrhea
Youngster 92 example, viral infantile diarrhea 128 example and noninfectious diarrhea 60 example.
Using the navel patch prepared by the embodiment of the present invention 3 to treat, every day two, patch was replaced, and within 5 days, was
One course for the treatment of, treatment carries out 2 courses for the treatment of, and follows up a case by regular visits to one month.
The standard of curative effect evaluation:
Curing: diarrhoea and dewatering symptom disappear, stool recovers normal, and infant appetite strengthens, spirit shape
State returns to normal；
Effective: diarrhoea and dewatering symptom have improvement, times of defecation and just amount to have improvement, infant appetite to have
Being strengthened, the mental status has improvement,；
It is invalid: diarrhoea and dewatering symptom even increase the weight of to lose without improving, times of defecation and just measure unchanged,
Infant appetite is poor, and the mental status is dispirited.
In treatment cycle, treatment group does not finds obvious adverse reaction, it is seen that Chinese medicine composition of the present invention can
Significantly reducing the untoward reaction of infant, drug safety is significantly larger than existing conventional Western medicine preparation.
After the treatment of two courses for the treatment of, observe the recovery situation of infant, and according to above-mentioned the standard of curative effect evaluation
Carrying out recording infant recovery situation, infant clinical data such as table 1 below is recorded.
Table 1 patient treatment situation
Knowable to upper table data, the Chinese medicine composition for the treatment of infantile diarrhea of the present invention, for children's
The complete treatment of diarrhoea has fabulous therapeutic effect, and its clinical cure rate is up to more than 98%.
Obviously, above-described embodiment is only for clearly demonstrating example, and not to embodiment party
The restriction of formula.For those of ordinary skill in the field, the most also may be used
To make other changes in different forms.Here without also all of embodiment being given
With exhaustive.And the obvious change thus extended out or variation are still in the guarantor of the invention
Protect among scope.
Claims (10)
1. the Chinese medicine composition treating infantile diarrhea, it is characterised in that the raw material of described compositions
Medicine composition includes: Radix orixae japonicae 40-80 weight portion, Poria 30-60 weight portion, Fructus Schisandrae Chinensis 40-70 weight
Part, Fructus Aurantii Immaturus 20-40 weight portion, Herba Houttuyniae 15-35 weight portion, Fructus Psoraleae 15-25 weight portion, Radix Puerariae
20-30 weight portion, Rhizoma Corydalis 8-15 weight portion, Olibanum 10-20 weight portion, Rhizoma Alismatis 6-15 weight portion,
Caulis Lonicerae 4-10 weight portion, Fructus Citri Sarcodactylis 3-9 weight portion, Fructus Viticis 5-10 weight portion.
The Chinese medicine composition for the treatment of infantile diarrhea the most according to claim 1, it is characterised in that
The crude drug composition of described compositions includes: Radix orixae japonicae 60 weight portion, Poria 45 weight portion, the five tastes
Son 55 weight portions, Fructus Aurantii Immaturus 30 weight portion, Herba Houttuyniae 25 weight portion, Fructus Psoraleae 20 weight portion, Pueraria lobota
Root 25 weight portion, Rhizoma Corydalis 12 weight portion, Olibanum 15 weight portion, Rhizoma Alismatis 10 weight portion, Radix Ophiopogonis
Rattan 7 weight portion, Fructus Citri Sarcodactylis 6 weight portion, Fructus Viticis 8 weight portion.
The Chinese medicine composition for the treatment of infantile diarrhea the most according to claim 1 and 2, its feature exists
In, described Chinese medicine composition adds customary adjuvant, makes the most acceptable dose according to common process
Type.
4., by the arbitrary described Chinese medicine composition of claim 1-3, add customary adjuvant, according to routine
Technique makes the external preparation of the most acceptable treatment infantile diarrhea.
Preparation the most according to claim 4, it is characterised in that described preparation includes patch or cream
Agent.
6. the method preparing the arbitrary described Chinese medicine composition of claim 1-3, it is characterised in that
Including according to selected parts by weight take described Radix orixae japonicae, Poria, Fructus Schisandrae Chinensis, Fructus Aurantii Immaturus, Herba Houttuyniae,
Fructus Psoraleae, Radix Puerariae, Rhizoma Corydalis, Olibanum, Rhizoma Alismatis, Caulis Lonicerae, Fructus Citri Sarcodactylis and Fructus Viticis, powder after mixing
Broken or pulverize after mixing step, and according to common process, add customary adjuvant, make and clinically may be used
The dosage form accepted.
The method preparing described Chinese medicine composition the most according to claim 6, it is characterised in that
Comprise the steps:
(1) described Radix orixae japonicae, Poria, Fructus Aurantii Immaturus, Fructus Psoraleae, Rhizoma Corydalis are taken according to selected parts by weight
Rope, Olibanum and Caulis Lonicerae mixing, collect decoction liquor, obtain Aqueous extracts after boiling, standby；
(2) described Fructus Schisandrae Chinensis, Herba Houttuyniae, Radix Puerariae, Rhizoma Alismatis, Fructus Citri Sarcodactylis are taken according to selected parts by weight
Mix with Fructus Viticis, add ethanol solution and carry out extract at room temperature, obtain alcohol extract, standby；
(3) described Aqueous extracts and alcohol extract are collected, and according to common process, interpolation customary adjuvant, system
Become the most acceptable dosage form.
8., according to the method preparing described Chinese medicine composition described in claim 6 or 7, its feature exists
In, comprise the steps:
(1) described Radix orixae japonicae, Poria, Fructus Aurantii Immaturus, Fructus Psoraleae, Rhizoma Corydalis are taken according to selected parts by weight
Rope, Olibanum and Caulis Lonicerae mixing, the water adding drug weight 2-4 weight times amount carries out decocting 1-3 time,
And collect decoction liquor, and obtain Aqueous extracts, standby；
(2) described Fructus Schisandrae Chinensis, Herba Houttuyniae, Radix Puerariae, Rhizoma Alismatis, Fructus Citri Sarcodactylis are taken according to selected parts by weight
Mix with Fructus Viticis, add the ethanol that mass concentration is 50-70wt% of drug weight 1-3 weight times amount
Solution carries out extract at room temperature 1-3 time, obtains alcohol extract, standby；
(3) described Aqueous extracts and alcohol extract are collected, and according to common process, interpolation customary adjuvant, system
Become the most acceptable dosage form.
9. the arbitrary described Chinese medicine composition of claim 1-3 is for preparing treatment infantile diarrhea medicine
Purposes.
Purposes the most according to claim 9, it is characterised in that described infantile diarrhea includes carefully
Bacterium property infantile diarrhea, viral infantile diarrhea and noninfectious diarrhea.
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Application publication date: 20161012 |