CN105998326B - A kind of complexing agent and preparation method thereof for eliminating bed body smell - Google Patents
A kind of complexing agent and preparation method thereof for eliminating bed body smell Download PDFInfo
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- CN105998326B CN105998326B CN201610417938.2A CN201610417938A CN105998326B CN 105998326 B CN105998326 B CN 105998326B CN 201610417938 A CN201610417938 A CN 201610417938A CN 105998326 B CN105998326 B CN 105998326B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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Abstract
The present invention relates to a kind of complexing agent and preparation method thereof for eliminating bed body smell, which is made of following raw materials: 1000-1200 milliliters of the ethyl alcohol of 60%-75%, 40-60 grams of acetylsalicylic acid, 45-60 grams of alumen, 40-50 grams of Schisandra chinensis, 45-60 grams of Chinese gall.Specific preparation method includes: that (1) grinds above-mentioned medicinal material, is mixed, and is sieved, 100 targeted fine powders are obtained；(2) fine powder is added in the glass container equipped with ethyl alcohol, stirring is mixed, and sealing impregnates 25-30 days at normal temperature, obtains medical fluid；(3) medical fluid is filtered, filtrate centrifugal treating takes supernatant, filling.The compound formula is simple, has no toxic side effect, and can thoroughly eliminate bed body smell.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to it is a kind of eliminate bed body smell compound formulation and its preparation side
Method.
Background technique
Bed body smell refers to that a certain position of body issues a kind of special foul smell, be with oxter, foot it is common, summer goes out
It is become apparent when sweat is more, the peculiar smell of human body is mainly since sweat gland secretion excessively causes.As the age increases, secretion is lost in vivo
Weighing apparatus, sweat gland secretion can increase, and some common mushrooms bred on skin will be using the higher fatty acids in sweat as food, will
It has resolved into the lower fatty acids such as the methylbutanoic acid to emit bad smell.For suffering from serious disease of digestive system, serious woman
Section's inflammation disease, excessive edible irritable food, cosmetics improper use, personal hygiene habit are bad etc. can also to cause body
It is smelly.There are peculiar smell, and people can be allowed especially awkward for body, while also influencing the air environment of surrounding, causes one to other people in public
Fixing is rung, and seriously affects the physical and mental health of patient and people from periphery.
Currently, the method for eliminating bed body smell specifically includes that (1) using modus operandi, cuts off patient's sweat gland, prevents to perspire
Carry out deodorization.This method can eliminate peculiar smell, but wound healing at that time, sweat gland regeneration, cannot with perspiring and output peculiar smell
Reach thorough deodorization, and brings pain to patient.(2) peculiar smell is covered using aromatic powder or aromatic.This method effect is more
Undesirable, strong fragrance and stink mixing, smell are more unpleasant.(3) sweat gland secretion is inhibited using drug therapy.Existing patent
CN961112689 discloses a kind of removing human body deodorization powder for hircismus or agent, deodorization powder for hircismus are made of acetylsalicylic acid powder,
Although can achieve the purpose that deodorization, a setting loss can be caused to skin using due to the acidity of acetylsalicylic acid for a long time
Wound.There are also some patents disclose using Chinese medicine as the deodorant of raw material, although effectively, the effect is unsatisfactory, some prescriptions
Complexity, cost of drugs are high；Some there are side effects, can damage to skin；Some deodorizing effects are single, are only applicable to body odour
Or foot odour, it is bad for the particular patients ' therapeutic effect of whole body body odor.
Summary of the invention
The object of the present invention is to provide a kind of formulas simply, has no toxic side effect, and can thoroughly eliminate answering for bed body smell
Mixture, the complexing agent are made of following raw materials: 1000-1200 milliliters of the ethyl alcohol of 60%-75%, 40-60 grams of acetylsalicylic acid, withered
45-60 grams of alum, 40-50 grams of Schisandra chinensis, 45-60 grams of Chinese gall.
As a preference of the present invention, the complexing agent is made of following raw materials: 75% 1000 milliliters of ethyl alcohol, acetyl salicylic
Sour 50 grams, 50 grams of alumen, 50 grams of Schisandra chinensis, 50 grams of Chinese gall.
It is a further object to provide a kind of preparation methods of complexing agent for eliminating bed body smell: this method includes
Following steps:
(1) acetylsalicylic acid, alumen, Schisandra chinensis, Chinese gall are weighed by the weight of constitutive material, carries out grounds travel respectively
It is broken, four kinds of drug powders are mixed, is sieved, 100 targeted fine powders is obtained；
(2) fine powder of step (1) is added in the glass container equipped with ethyl alcohol, stirring is mixed, and sealing is impregnated at normal temperature
25-30 days, obtain medical fluid；
(3) medical fluid of step (2) is filtered, filtrate centrifugal treating takes supernatant, filling.
Raw material effect of complexing agent of the present invention is selected as follows:
Acetylsalicylic acid, molecular formula: C9H8O4, molecular structural formula are as follows: CH3COOC6H4COOH, molecular weight are as follows: 180.16,
It can effectively sterilize, inhibit sweat gland secretion.
Alumen, it is sour, it is cold in nature.[effect] dissolving phlegm, eliminating dampness, antidiarrheal, stop blooding, removing toxic substances, desinsection, have it is extremely strong convergence, it is dry
Wet effect.
Chinese gall, it is cold in nature, it is sour, puckery.[effect] astringing lung-QI fall fire, relieving diarrhea with astringents, arrest sweating hemostasis, hygroscopic sore and other effects,
With the sweat effect that disappears by force very much.In vitro test shows Chinese gall decoction to staphylococcus aureus, beta hemolytic streptococcus, lung
Scorching coccus, Pseudomonas aeruginosa, shigella dysenteriae, bacillus anthracis, corynebacterium diphtheriae, Escherichia coli, Typhoid and paratyphoid bacillus etc. have bright
Aobvious antibacterial and bactericidal effect.
Schisandra chinensis, it is sour, it is cold in nature, it is nontoxic.[effect], which has, astringes the lung to stop cough, nourishes the benefits of arresting seminal emission, antidiarrheal, hidroschesis.
Usage and dosage: external application takes every time and smears or be sprayed at clean affected part (oxter, trick etc.) in right amount, the morning and evening each 1
Secondary, 7-14 days as a treatment course can thoroughly eliminate peculiar smell, smell salubrious.Product using when not be sprayed onto eyes or mouth never
In.
The advantages and positive effects of the present invention:
(1) its formula of the complexing agent of the present invention for eliminating bed body smell and preparation process are simple, easy to use, treatment
It is wide, it is effective to stink caused by underarm odor, foot odour, gynecological disease and whole body body odor patient, and significant effect, cure rate reach
100%, and difficulty in relapse after healing is controlled, skin is not damaged, is had no toxic side effect.
(2) complexing agent of the present invention for eliminating bed body smell solves Western medicine and is unable to sample by Western medicine in conjunction with Chinese medicine
Simultaneous the shortcomings that controlling, the deficiency of Western medicine is made up using Chinese medicine, Chinese and Western medicine collaboration plays therapeutic effect, compound formulation initial stage is enable to solve
Certainly Peculiar Smell, application can also fundamentally treat bed body smell for a long time, thoroughly eliminate peculiar smell, make indoor environment (especially
It is at crowd massing) it is with fresh air, it beautifies the environment.
(3) complexing agent of the present invention for eliminating bed body smell can be used not only for human body, can be also used for toy
With, peculiar smell can be effectively eliminated, solves air pollution problem inside rooms from the root, air environment is purified, keeps it more pure and fresh,
The complexing agent, which can be used as, improves one of effective method of social groups' environment.
The clinical observation material of drug of the present invention
1, case selection
Patient totally 166 people, male patient 116, the age between 25-60 years old, underarm odor 48, foot odour
68；Female patient 50, the age between 35-55 years old, underarm odor 30, foot odour 20.
2, diagnostic criteria
Underarm odor: patient environmental's temperature one is high or mood is more nervous, oxter will abnormal excessive perspiration, and issue
Unpleasant taste.
Foot odour: foot has strong smell compared with other body parts, or even can give out a foul smell.
3, treatment method
The drug of selection example 4 is used to patient, and once a day, early morning uses, and patient cleans affected part (foot or oxter)
Afterwards, drug is applied to affected part, naturally dry was adhered to using 14 days.
4, the standard of curative effect evaluation
Effective: stink is eliminated, and smells salubrious, and it is normal to perspire recovery, is observed after half a year without recurrence；
Improve: the symptoms were significantly improved for stink, and physical fitness is obviously restored；
Invalid: improvement standard person is not achieved without improvement in symptom.
5, treatment results
| Type | Total cases | Treatment time | It is effective | It improves | In vain | Total effective rate |
| Underarm odor | 78 | 14 days | 94.6% | 6.4% | 0% | 100% |
| Foot odour | 88 | 14 days | 94.2% | 6.8% | 0% | 100% |
For drug of the present invention during treatment, some patientss medication has just completely eliminated abnormal smell of body, medication 7 after 4-5 days
After it, all patients eliminate abnormal smell of body, and continuous use effectively prevent recurring for 14 days.
The typical case contacted during drug therapy of the present invention
Case 1: so-and-so, male, 29 years old, inhabitation Chaoyang district of Changchun city, readme just suffered from whole body body odor since 17 years old
Problem, with advancing age, body are got fat, and body odor problem is increasingly severe, and the whole bodies such as hand, foot, oxter have a peculiar smell, on foot
It is particularly acute, and is particularly easy to perspire, summer is even more serious, even if wearing clothes or 0.5 meter of shoes interval can be smelt
Peculiar smell on body, seriously affects interpersonal relationships and quality of life, uses many drugs such as ZUGUANG SAN, but effect and pays no attention to
Think, only can temporarily mitigate body odor problem, peculiar smell can not be completely removed, and interval one end time can recur again.Selection uses
Drug of the present invention dries body after bathing once a day (early morning use), drug is applied to whole body, naturally dry uses 4
Sweat significantly reduces after it, and body stink disappears substantially, is thoroughly disappeared using body stink after 7 days, continues to use 7 days, perspires
And smell is normal.Treat later six months still without recurrence, even and if whole body use, body also without any adverse reaction, and
And feel dry and comfortable, very comfortably.
Case 2: Chen, female, 45 years old, inhabitation Gongzhuling City Shuangcheng fort town, readme suffered from serious woman since 2013
Section's disease (vaginitis, cervicitis), leukorrhea amount is more, and color is dark red, sticky, there is bad smell, even if cleaning is not still effective daily,
A variety of drugs such as your clean yin were used, but effect is bad, gynaecological imflammation is not alleviated, and bad smell does not mitigate.Selection uses this
Invention drug after cleaning perineum, drug is sprayed at perineum, is subtracted using leukorrhea amount after 2 days once a day (early morning use)
Few, bad smell mitigates, normal using leukorrhea amount after 5 days, and bad smell disappears, and continues to use 8 days, smell and leukorrhea indices are equal
Normally, treatment later six months does not recur.
Specific embodiment
Embodiment 1
Raw material: 60% 1000 milliliters of ethyl alcohol, 40 grams of acetylsalicylic acid, 60 grams of alumen, 40 grams of Schisandra chinensis, Chinese gall
60 grams；
Preparation method:
(1) acetylsalicylic acid, alumen, Schisandra chinensis, Chinese gall are weighed by the weight of above-mentioned raw materials, carries out grounds travel respectively
It is broken, then four kinds of drug powders are mixed, 100 targeted fine powders are obtained；
(2) fine powder of step (1) is put into the glass container equipped with 60% ethyl alcohol, stirring is mixed, sealing, in room temperature
Under (24 DEG C -26 DEG C), impregnates 25 days, obtain medical fluid；
(3) medical fluid of step (2) is filtered, filtrate centrifugal treating (revolving speed: 1500 turns/min, divide by centrifugal treating 5
Clock), supernatant is taken, it is filling.
Embodiment 2
Raw material: 75% 1000 milliliters of ethyl alcohol, 60 grams of acetylsalicylic acid, 45 grams of alumen, 50 grams of Schisandra chinensis, Chinese gall
45 grams；
Preparation method:
(1) acetylsalicylic acid, alumen, Schisandra chinensis, Chinese gall are weighed by the weight of above-mentioned raw materials, carries out grounds travel respectively
It is broken, then four kinds of drug powders are mixed, 100 targeted fine powders are obtained；
(2) fine powder of step (1) is put into the glass container equipped with 75% ethyl alcohol, stirring is mixed, sealing, in room temperature
Under (24 DEG C -26 DEG C), impregnates 30 days, obtain medical fluid；
(3) medical fluid of step (2) is filtered, filtrate centrifugal treating (revolving speed: 1500 turns/min, divide by centrifugal treating 5
Clock), supernatant is taken, it is filling.
Embodiment 3
Raw material: 75% 1000 milliliters of ethyl alcohol, 50 grams of acetylsalicylic acid, 55 grams of alumen, 45 grams of Schisandra chinensis, Chinese gall
55 grams；
Preparation method:
(1) acetylsalicylic acid, alumen, Schisandra chinensis, Chinese gall are weighed by the weight of above-mentioned raw materials, carries out grounds travel respectively
It is broken, then four kinds of drug powders are mixed, 100 targeted fine powders are obtained；
(2) fine powder of step (1) is put into the glass container equipped with 75% ethyl alcohol, stirring is mixed, sealing, in room temperature
Under (24 DEG C -26 DEG C), impregnates 30 days, obtain medical fluid；
(3) medical fluid of step (2) is filtered, filtrate centrifugal treating (revolving speed: 1500 turns/min, divide by centrifugal treating 5
Clock), supernatant is taken, it is filling.
Embodiment 4
Raw material: 75% 1000 milliliters of ethyl alcohol, 50 grams of acetylsalicylic acid, 50 grams of alumen, 50 grams of Schisandra chinensis, Chinese gall
50 grams；
Preparation method:
(1) acetylsalicylic acid, alumen, Schisandra chinensis, Chinese gall are weighed by the weight of above-mentioned raw materials, carries out grounds travel respectively
It is broken, then four kinds of drug powders are mixed, 100 targeted fine powders are obtained；
(2) fine powder of step (1) is put into the glass container equipped with 75% ethyl alcohol, stirring is mixed, sealing, in room temperature
Under (24 DEG C -26 DEG C), impregnates 30 days, obtain medical fluid；
(3) medical fluid of step (2) is filtered, filtrate centrifugal treating (revolving speed: 1500 turns/min, divide by centrifugal treating 5
Clock), supernatant is taken, it is filling.
Comparative example 1
Raw material: 75% 1000 milliliters of ethyl alcohol, 50 grams of acetylsalicylic acid, 30 grams of alumen, 50 grams of Schisandra chinensis, Chinese gall
50 grams；
Preparation method: with embodiment 4
Comparative example 2
Raw material: 75% 1000 milliliters of ethyl alcohol, 50 grams of acetylsalicylic acid, 50 grams of alumen, 50 grams of Schisandra chinensis, Chinese gall
30 grams；
Preparation method: with embodiment 4
Comparative example 3
Raw material: 75% 1000 milliliters of ethyl alcohol, 50 grams of acetylsalicylic acid, 50 grams of alumen, 50 grams of Schisandra chinensis, Chinese gall
70 grams；
Preparation method: with embodiment 4
The present invention has done many experiments during researching and developing this compound preparation, has successfully invented above-mentioned prescription, on
The raw material for stating compound preparation is indispensable, and weight proportion is extremely important, and each component is more, can have one to wholistic therapy effect less
Fixed influence.The present invention used comparative example 1, comparative example 2, made from comparative example 3 to different patients respectively in the course of the research
Drug, but therapeutic effect is unsatisfactory, using still there is slight body odor after two weeks, abnormal smell of body can only mitigate patient, cannot
Thoroughly eliminate.
Claims (4)
1. a kind of complexing agent for eliminating bed body smell, which is characterized in that the complexing agent is made of following raw materials: 60%-75%'s
1000-1200 milliliters of ethyl alcohol, 40-60 grams of acetylsalicylic acid, 45-60 grams of alumen, 40-50 grams of Schisandra chinensis, 45-60 grams of Chinese gall.
2. a kind of complexing agent for eliminating bed body smell according to claim 1, which is characterized in that the complexing agent is by following
Raw material is made: 75% 1000 milliliters of ethyl alcohol, 50 grams of acetylsalicylic acid, 50 grams of alumen, 50 grams of Schisandra chinensis, 50 grams of Chinese gall.
3. a kind of preparation method of complexing agent for eliminating bed body smell according to claim 1, which is characterized in that this method
The following steps are included:
(1) acetylsalicylic acid, alumen, Schisandra chinensis, Chinese gall are weighed by the weight of constitutive material, is ground respectively, it will
Four kinds of drug powders are mixed, and 100 targeted fine powders are obtained in sieving；
(2) fine powder of step (1) is added in the glass container equipped with ethyl alcohol, stirring is mixed, and 25- is impregnated in sealing at normal temperature
30 days, obtain medical fluid；
(3) medical fluid of step (2) is filtered, filtrate centrifugal treating takes supernatant, filling.
4. a kind of preparation method of complexing agent for eliminating bed body smell according to claim 3, which is characterized in that when immersion
Temperature is controlled at 24 DEG C -26 DEG C.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1290521A (en) * | 1999-11-04 | 2001-04-11 | 简子和 | Multifunctional health care ointment |
| CN1358468A (en) * | 2000-12-19 | 2002-07-17 | 王守卷 | Luffa medicinal insole and making method thereof |
| CN102379995A (en) * | 2010-09-01 | 2012-03-21 | 马福祥 | Traditional Chinese medicine combination for suppressing and treating odor of human bodies |
| CN102451213A (en) * | 2010-10-25 | 2012-05-16 | 张学军 | Liniment for removing bromhidrosis |
| CN103550408A (en) * | 2013-10-31 | 2014-02-05 | 都匀市叶咔香生物科技厂 | Pharmaceutical composition for removing human body odors, preparation containing same and preparation method of composition |
-
2016
- 2016-06-15 CN CN201610417938.2A patent/CN105998326B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1290521A (en) * | 1999-11-04 | 2001-04-11 | 简子和 | Multifunctional health care ointment |
| CN1358468A (en) * | 2000-12-19 | 2002-07-17 | 王守卷 | Luffa medicinal insole and making method thereof |
| CN102379995A (en) * | 2010-09-01 | 2012-03-21 | 马福祥 | Traditional Chinese medicine combination for suppressing and treating odor of human bodies |
| CN102451213A (en) * | 2010-10-25 | 2012-05-16 | 张学军 | Liniment for removing bromhidrosis |
| CN103550408A (en) * | 2013-10-31 | 2014-02-05 | 都匀市叶咔香生物科技厂 | Pharmaceutical composition for removing human body odors, preparation containing same and preparation method of composition |
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