CN105998275A - Composition for treating pelteobagrus fulvidraco enteritis disease - Google Patents

Composition for treating pelteobagrus fulvidraco enteritis disease Download PDF

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Publication number
CN105998275A
CN105998275A CN201610390202.0A CN201610390202A CN105998275A CN 105998275 A CN105998275 A CN 105998275A CN 201610390202 A CN201610390202 A CN 201610390202A CN 105998275 A CN105998275 A CN 105998275A
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parts
group
experiment
enteritis disease
mass fraction
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叶延青
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Rongchang Helicopter Raising Fisheries Cooperatives
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Rongchang Helicopter Raising Fisheries Cooperatives
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/748—Oldenlandia or Hedyotis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention belongs to the field of aquaculture, and in particular, discloses a composition for treating pelteobagrus fulvidraco enteritis disease, wherein the composition comprises the components in parts by mass: 9-13 parts of amaranthus blitum, 5-7 parts of polystichum craspedosorum, 5-7 parts of rhizoma menispermi, and 3-5 parts of hedyotis auricularia. The curing rate of the composition on pelteobagrus fulvidraco enteritis disease can reach 85% or more.

Description

A kind of compositions treating yellow peppery fourth enteritis disease
Technical field
The present invention relates to aquaculture field, be specifically related to a kind of compositions treating yellow peppery fourth enteritis disease.
Background technology
Yellow peppery fourth, belongs to Silurformes, section, Pelteobagrus；Have another name called Pelteobagrus fulvidraco, Huang Guyu, yellow bone fish, beeswax fourth etc..Yellow peppery Fourth distribution is wide, and in addition to western plateau, all there is distribution in national each waters.Though it is individual less, but yield is big.Fine and tender taste, nothing Spinule, fattiness, its protein content is 16.1%, and fat is 0.7%, is the common edible fishes of China.
Enteritis disease is one of disease the most serious in China's cultured fishes, and its cause of disease is addicted to aqueous vapor pseudomonas bacillus, for Gram-negative Bacterium.Suffering from the peppery fourth of Huang of enteritis disease to peel off solely trip, slow trip, fish body turns black, few food or do not eat；Abdominal part expands, and presents erythema, Anus redness highlights；Mention disease fish head portion, have faint yellow mucus to flow out from anus；Cut intestinal tube, intestinal wall hyperemia inflammation, enteric cavity open Inside do not have food or only back segment at intestinal have a small amount of feces, the how faint yellow mucus of enteral, intestinal wall poor flexibility, scale is easy to fall off, makes Become Fish mortality, this disease main harm fingerling and adult fish.
The method of traditional treatment enteritis disease is: oral medicine (mixing is pressed into pellet in feedstuff) sulfadimidine sheet, every 50 kilograms of baits Material adds 15-20 gram feed 3 days continuously, feed 2 times day or add oxytetracycline 20 grams with furazolidone 10 grams and mix 50 kilograms of bait of addition thoroughly In, to feed 3 days continuously, day feeds 2 times；Also can use oral penicillin capsule, add (5 grams) in pan feeding and feed 3 days continuously, day feeds 2 Secondary.Spice now joins existing feeding, and joins 1 time and feeds 3 days.Above method to the cure rate of yellow peppery fourth enteritis disease at 70%-75%.
Summary of the invention
It is an object of the invention to provide a kind of compositions treating yellow peppery fourth enteritis disease, yellow peppery fourth enteritis disease is controlled by said composition More rate can reach more than 85%.
For reaching above-mentioned purpose, the base case of the present invention is: a kind of compositions treating yellow peppery fourth enteritis disease, according to mass parts Number meter, including concave head Herba Amaranthi tricoloris 9-13 part, Polystichum craspedosorum (Maxim.) Diels. 5-7 part, Rhizoma Menispermi 5-7 part, Auricled Hedyotis Herb 3-5 part.
Concave head Herba Amaranthi tricoloris has clearing away heat-damp and promoting diuresis；For enteritis, dysentery, swelling and pain of hemorrhoid is hemorrhage.Polystichum craspedosorum (Maxim.) Diels. has effect of heat-clearing and toxic substances removing；Main Furuncle and phyma, enteritis.Rhizoma Menispermi has heat-clearing and toxic substances removing, effect of wind-expelling pain-stopping；For enteritis and dysentery, rheumatic arthralgia.Auricled Hedyotis Herb has Heat-clearing and toxic substances removing, effect of removing heat from blood detumescence；For cold, fever, acute conjunctivitis, enteritis, dysentery.
The program have the beneficial effect that one be treat yellow peppery fourth enteritis disease remarkably productive, cure rate reaches more than 85%；Two is to select Chinese herbal medicine treats enteritis disease, while regulation fish internal milieu balance, increases fish body immunity, improves yellow peppery fourth and resist it The ability of his disease.
Prioritization scheme one: the optimization as to base case: according to mass fraction meter, also comprises rice 7-9 part, Bulbus Allii 7-9 Part.Rice has antiinflammatory, effect of sterilization.Garlic bulb contains volatile oil about 2%, is mainly composed of allicin in oil, for A kind of phytocide.Uncooked garlic is in vitro to pyococcus, tubercule bacillus, dysentery bacterium, Bacillus typhi, paratyphoid fever Bacillus, vibrio cholera etc. all have inhibitory action；To green grass or young crops, chain, chlorine, chlortetracycline drug resistance antibacterial the most sensitive to garlic preparation.Raw Bulbus Allii infusion has stronger bacteriostasis in vitro to meningococcus；Multiple pathogenic dermatophytes (is included white thought Pearl bacterium) all there are inhibitory action in various degree or killing action；Dermacetor orientalis is had and the strongest presses down the power of killing.Bulbus Allii has Stomach invigorating, dysentery relieving, cough-relieving, sterilization, effect of anthelmintic；Influenza, epidemic cerebrospinal meningitis can be prevented；Control pulmonary tuberculosis, Pertussis, inappetence, dyspepsia, bacillary dysentery, amebic dysentery, enteritis, enterobiasis, ancylostomiasis；External is controlled Trichomonas vaginitis, acute appendicitis.The beneficial effect of this programme, in addition to treating yellow peppery fourth enteritis disease, also has and kills addicted to aqueous vapor list Effect of born of the same parents bacillus.
Prioritization scheme two: the optimization as to prioritization scheme one: Flos Chrysanthemi Indici 5-7 part, Herba Paederiae 5-7 part.Flos Chrysanthemi Indici has clearly Effect of thermal detoxification.Herba Paederiae has expelling wind and activating blood circulation, analgesic antidotal, dyspepsia and intestinal stasis relieving, effect of dehumidifying detumescence；Dispelling the wind and dampness pathogens pain, Diarrhoea dysentery, stomachache, deficiency of vital energy edema, dizzy lack of appetite, hepatosplenomegaly, scrofula, acute appendicitis, innominate toxic swelling, traumatic injury.This Scheme adds the effect dissipating poison, can alleviate the malaise symptoms of yellow peppery fourth, promotes recovery from illness.
Prioritization scheme three: the optimization as to prioritization scheme two: according to mass fraction meter, also includes Armillaria matsutake 6-9 part, Gaster caprae seu Ovis dish 4-6 part.Armillaria matsutake has beneficial the intestines and stomach, regulating QI to relieve pain, the effect reduced phlegm.Gaster caprae seu Ovis dish has beneficial the intestines and stomach, effect of phlegm-eliminiating and qi-regulating.Add Add this two tastes Chinese medicine, can promote, with tonification the intestines and stomach, the Huang peppery fourth recovery from illness suffering from enteritis disease.
Detailed description of the invention
Below by detailed description of the invention, the present invention is further detailed explanation:
Setup Experiments blank group, matched group, experiment A group, experiment B group, experiment C group, experiment D group, experiment E group, experiment F Group, experiment G group and experiment H group.Each group with an independent culturing pool.500 tails are suffered from the sick fish of moderate enteritis disease with Machine is all assigned in 10 groups, often organizes 50 tails.Artifical compound feed formula: fish flour 30%～40%, rape cake 10%～35%, bean Cake 20～30%, wheat-middlings 15%～18%, Testa oryzae 10%～15%, food attractant-growth promoting additive 2%～5%.Divided by lower process Outside difference, remaining condition is the most identical:
Blank group: not treated with medicaments.
Matched group: bleaching powder full pond float, makes water become the concentration of lmg/L；Admix in feedstuff with furazolidone and oxytetracycline simultaneously (furazolidone: oxytetracycline: feedstuff=1:2:5000), feeds 3 days continuously, and day feeds 2 times.
Experiment A group: use compositions, according to mass fraction meter, including concave head Herba Amaranthi tricoloris 9 parts, Polystichum craspedosorum (Maxim.) Diels. 7 parts, Rhizoma Menispermi 7 Part, Auricled Hedyotis Herb 3 parts.
Experiment B group: use compositions, according to mass fraction meter, including concave head Herba Amaranthi tricoloris 13 parts, Polystichum craspedosorum (Maxim.) Diels. 5 parts, Rhizoma Menispermi 5 Part, Auricled Hedyotis Herb 5 parts.
Experiment C group: use compositions, according to mass fraction meter, including concave head Herba Amaranthi tricoloris 10 parts, Polystichum craspedosorum (Maxim.) Diels. 6 parts, Rhizoma Menispermi 6 Part, Auricled Hedyotis Herb 4 parts, rice 7 parts, 9 parts of Bulbus Allii.
Experiment D group: use compositions, according to mass fraction meter, including concave head Herba Amaranthi tricoloris 9.5 parts, Polystichum craspedosorum (Maxim.) Diels. 6.4 parts, Rhizoma Menispermi 5.6 parts, Auricled Hedyotis Herb 4.4 parts, rice 9 parts, 7 parts of Bulbus Allii.
Experiment E group: use compositions, according to mass fraction meter, including concave head Herba Amaranthi tricoloris 11 parts, Polystichum craspedosorum (Maxim.) Diels. 5.2 parts, Rhizoma Menispermi 5.1 parts, Auricled Hedyotis Herb 3.3 parts, rice 8 parts, 8 parts of Bulbus Allii, Flos Chrysanthemi Indici 5 parts, Herba Paederiae 7 parts.
Experiment F group: use compositions, according to mass fraction meter, including concave head Herba Amaranthi tricoloris 12 parts, Polystichum craspedosorum (Maxim.) Diels. 6.3 parts, Rhizoma Menispermi 6.9 parts, Auricled Hedyotis Herb 3.7 parts, rice 7.7 parts, 8.8 parts of Bulbus Allii, Flos Chrysanthemi Indici 7 parts, Herba Paederiae 5 parts.
Experiment G group: use compositions, according to mass fraction meter, including concave head Herba Amaranthi tricoloris 11.6 parts, Polystichum craspedosorum (Maxim.) Diels. 5.7 parts, north bean Root 5.3 parts, Auricled Hedyotis Herb 4.8 parts, rice 8.8 parts, 7.6 parts of Bulbus Allii, Flos Chrysanthemi Indici 6 parts, Herba Paederiae 6 parts, Armillaria matsutake 6 parts, Gaster caprae seu Ovis dish 6 parts.
Experiment H group: use compositions, according to mass fraction meter, including concave head Herba Amaranthi tricoloris 9.7 parts, Polystichum craspedosorum (Maxim.) Diels. 6.6 parts, north bean Root 6.2 parts, Auricled Hedyotis Herb 4.5 parts, rice 7.5 parts, 7.5 parts of Bulbus Allii, Flos Chrysanthemi Indici 5.5 parts, Herba Paederiae 6.6 parts, Armillaria matsutake 9 Part, Gaster caprae seu Ovis dish 4 parts.
Experiment A group, to each Chinese medicinal components (except Bulbus Allii) in experiment H group, decocts compositions according to the method for decocting herb, Medicinal liquid and medicinal residues；Bulbus Allii is squeezed the juice, by Bulbus Allii juice and liquid medicine mixing, obtains admixing medical solutions；By admixing medical solutions according to 0.5L/m3Use Amount is splashed full pond, every day 1 time, for three days on end；Powder beaten by medicinal residues, medicinal residues powder and feedstuff is thrown something and fed yellow peppery fourth according to the ratio of 1:14, Every day 2 times, for three days on end.
After 3 days, experimental result is as follows:
Blank group Matched group Experiment A group Experiment B group Experiment C group Experiment D group Experiment E group Experiment F group Experiment G group Experiment H group
Cure (tail) 0 36 43 45 43 46 45 47 46 48
Take a turn for the better (tail) 0 11 7 4 7 3 5 3 4 2
Dead (tail) 44 3 0 1 0 1 0 0 0 0
Result is added up:
Blank group: dead 44 tail, other 6 shape of tail states are very poor, tend to disease and die；Mortality rate 88%.
Matched group: cure rate 72%, improvement rate 22%, mortality rate 6%.
Experiment A group: cure rate 86%, improvement rate 14%, mortality rate 0.
Experiment B group: cure rate 90%, improvement rate 8%, mortality rate 2%.
Experiment C group: cure rate 86%, improvement rate 14%, mortality rate 0.
Experiment D group: cure rate 92%, improvement rate 6%, mortality rate 2%.
Experiment E group: cure rate 90%, improvement rate 10%, mortality rate 0.
Experiment F group: cure rate 94%, improvement rate 6%, mortality rate 0.
Experiment G group: cure rate 92%, improvement rate 8%, mortality rate 0.
Experiment H group: cure rate 96%, improvement rate 4%, mortality rate 0.
Interpretation of result: experiment A group and B group are to have employed the base case of the present invention, experiment C group is to use to experiment H group The preferred version of base case, the cure rate of these eight experimental grouies is all significantly better than using the matched group of conventional solution, extremely Rate of dying is significantly lower than matched group.As can be seen here, the present invention compared to existing technology, has prominent substantive distinguishing features and significantly enters Step.
Above-described is only embodiments of the invention, and in scheme, the known general knowledge such as using method and characteristic is too much retouched at this State.It should be pointed out that, for a person skilled in the art, under the premise of not departing from the present invention, it is also possible to make some changing Entering, these also should be considered as protection scope of the present invention, and these are all without affecting effect and the practical applicability that the present invention implements. The protection domain that this application claims should be as the criterion with the content of its claim, and the detailed description of the invention in description etc. is recorded permissible For explaining the content of claim.

Claims (4)

1. the compositions treating yellow peppery fourth enteritis disease, it is characterised in that: according to mass fraction meter, including concave head Herba Amaranthi tricoloris 9-13 part, Polystichum craspedosorum (Maxim.) Diels. 5-7 part, Rhizoma Menispermi 5-7 part, Auricled Hedyotis Herb 3-5 part.
A kind of compositions treating yellow peppery fourth enteritis disease the most according to claim 1, it is characterised in that: according to mass fraction meter, Also comprise rice 7-9 part, Bulbus Allii 7-9 part.
A kind of compositions treating yellow peppery fourth enteritis disease the most according to claim 2, it is characterised in that: according to mass fraction meter, Also include Flos Chrysanthemi Indici 5-7 part, Herba Paederiae 5-7 part.
A kind of compositions treating yellow peppery fourth enteritis disease the most according to claim 3, it is characterised in that: according to mass fraction meter, Also include Armillaria matsutake 6-9 part, Gaster caprae seu Ovis dish 4-6 part.
CN201610390202.0A 2016-06-03 2016-06-03 Composition for treating pelteobagrus fulvidraco enteritis disease Pending CN105998275A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101757395A (en) * 2009-12-15 2010-06-30 邵为旭 Traditional Chinese medicine for preventing and curing enteritis disease of grass carp
CN103690613A (en) * 2013-12-09 2014-04-02 陈永泉 Traditional Chinese medicine for treating pseudomembranous enteritis
CN104116858A (en) * 2014-07-02 2014-10-29 华洪萍 A traditional Chinese medicine for treating pseudomembranous enteritis
CN104706866A (en) * 2015-02-26 2015-06-17 王燕 Traditional Chinese medicine preparation for treating enteritis and preparation method of traditional Chinese medicine preparation
CN106035420A (en) * 2016-05-30 2016-10-26 宿州天雨养殖（集团）有限公司 Chinese herbal medicine formula for sterilizing indoor environment of farm

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101757395A (en) * 2009-12-15 2010-06-30 邵为旭 Traditional Chinese medicine for preventing and curing enteritis disease of grass carp
CN103690613A (en) * 2013-12-09 2014-04-02 陈永泉 Traditional Chinese medicine for treating pseudomembranous enteritis
CN104116858A (en) * 2014-07-02 2014-10-29 华洪萍 A traditional Chinese medicine for treating pseudomembranous enteritis
CN104706866A (en) * 2015-02-26 2015-06-17 王燕 Traditional Chinese medicine preparation for treating enteritis and preparation method of traditional Chinese medicine preparation
CN106035420A (en) * 2016-05-30 2016-10-26 宿州天雨养殖（集团）有限公司 Chinese herbal medicine formula for sterilizing indoor environment of farm

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