CN105998220A - Traditional Chinese veterinary material medicine for treating endometritis of cows as well as preparation method and use of traditional Chinese veterinary material medicine - Google Patents
Traditional Chinese veterinary material medicine for treating endometritis of cows as well as preparation method and use of traditional Chinese veterinary material medicine Download PDFInfo
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- CN105998220A CN105998220A CN201610564986.4A CN201610564986A CN105998220A CN 105998220 A CN105998220 A CN 105998220A CN 201610564986 A CN201610564986 A CN 201610564986A CN 105998220 A CN105998220 A CN 105998220A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese veterinary material medicine for treating endometritis. The traditional Chinese veterinary material medicine is a preparation prepared from the following raw material medicines in parts by weight: 1-3 parts of flavescent sophora roots, 0.5-1.5 parts of roots of herbaceous peonies, and 0.5-1.5 parts of Chinese starjasmine stems. The invention further discloses a preparation method and use of the traditional Chinese veterinary material medicine. The traditional Chinese veterinary material medicine disclosed by the invention is precise and appropriate in formula, can effectively treat endometritis and is free from toxic and side effects and favorable in clinical application prospects.
Description
Technical field
The present invention relates to a kind of herbal medicine treating cow endometritis and its production and use.
Background technology
Cow endometritis is modal a kind of cow reproduction systemic disease, causes milch cow infertile
One of the main reasons, and the infertility of cattle is the key factor of restriction animal husbandry development.Primary disease the lighter affects
Conception rate, increases tire spacing, and severe one intrauterine environment is destroyed, and endocrine regulation easily causes
Not feelings or oestrus irregular, cause embryonic death or miscarriage, and secondary mastitis, laminitis, due to
A large amount of toxin secretion, cause autonomic nervous dysfunction, induce gastrointestinal disease, it should cause numerous raisers'
Pay much attention to.Beijing Agricultural University investigates the milch cow in 16 cities such as Beijing, Nanjing, Shanghai, finds domestic
The sickness rate of endometrial inflammation is up to 17.26%, accounts for the 68.34% of not calver, makes to milk cow production
Become huge economic loss.The U.S. loses 2.5 hundred million dollars every year because of barrenness of milk cow, and Britain's report is infertile
The sickness rate of cattle about 95% is endometrial inflammation.The infertile aquaculture cost that adds of milch cow, reduces economy effect
Benefit, affects the development of milk cow production.Endometrial inflammation is the primary factor causing milch cow infertile, institute
With, industry research and technical staff attach great importance to the preventing and treating of endometrial inflammation.
The most conventional medicine has: the medicines such as antibiotic, furans, Operand.Although this kind of medicine can
To reach the purpose for the treatment of, but life-time service pathogen can develop immunity to drugs and be substantially reduced curative effect, in addition
There iing residual with in the Lac Bovis seu Bubali again of medicine after antibiotic therapy and milk, the quality of milk can affected.Therefore grind
Low toxicity processed, the Green medicament of low-residual are unusual Chinese medicine.
Chinese medicine belongs to natural product, and toxicity is low, less residue, is not likely to produce Drug resistance, and application prospect is good
Good.
Summary of the invention
It is an object of the present invention to provide a kind of herbal medicine treating cow endometritis and preparation method thereof and
Purposes.
A kind of herbal medicine for treating endometritis, it is to be prepared by the crude drug of following weight proportion
Preparation: Radix Sophorae Flavescentis 1～3 parts, Radix Paeoniae Rubra 0.5～1.5 parts, Caulis Trachelospermi 0.5～1.5 parts.
Preferably, it is the preparation being prepared from by the crude drug of following weight proportion: Radix Sophorae Flavescentis 2 parts, red
Chinese herbaceous peony 1 part, Caulis Trachelospermi 1 part.
Wherein, described herbal medicine be the water by each raw material or/and ethanol extraction is active component, add medicine-feeding
The preparation that adjuvant conventional in product or complementary composition are prepared from.
Wherein, described preparation be described preparation be vagina administration preparation.
Wherein, described vagina administration preparation is infusion liquid, lotion, suppository, drop, unguentum, powder.
Wherein, described infusion liquid is uterus perfusion.
Present invention also offers the preparation method of aforementioned herbal medicine, it comprises the steps:
(1) each raw material is weighed by weight ratio；
(2) water of raw material is taken or/and ethanol extraction, auxiliary with what food, health product or medicine were commonly used
Material or complementary composition are prepared as preparation.
Wherein, the preparation method of described extract is: take Radix Sophorae Flavescentis, Radix Paeoniae Rubra, Caulis Trachelospermi, boiling,
Ethanol precipitates,.Preferably, the preparation method of described extract is: the preparation of described water extract
Method is: takes Radix Sophorae Flavescentis, Radix Paeoniae Rubra, Caulis Trachelospermi, boiling, 2 times, each 2 hours, concentrates, past
Concentrated solution adds ethanol to alcohol content and reaches 65%, stand 12 hours, filter, then add toward filtrate
Ethanol makes alcohol content reach 75%, stands 12 hours, filters, and volatilize ethanol,.
Present invention also offers aforementioned herbal medicine purposes in the herbal medicine of preparation treatment endometritis.
Wherein, the herbal medicine for the treatment of endometritis is the herbal medicine for the treatment of cow endometritis.
Caulis Trachelospermi, CAULIS TRACHELOSPERMI, this product is apocynaceae plant trachelospermum jasminoide
The dry zone leaf rattan of Trachelospermumjasminoides (Lindl.) Lem..Winter adopted to time spring
Cut, remove impurity, dry.Hardship, is slightly cold.GUIXIN, liver, kidney channel.Curing mainly dispelling wind and removing obstruction in the collateral, removing heat from blood disappears
Swollen.For beriberoid pyretic arthralgia, muscle arteries and veins contracture, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.
Radix Paeoniae Rubra, RADIX PAEONIAE RUBRA, another name mountain Radix Paeoniae, Paeonia obovata Maxim..This product is hair
Gelsemium section plant peony Paeonialactiflora Pall. or river Radix Paeoniae Rubra Paeoniaveitchii Lynch is dried
Root.Spring, season in autumn two excavate, and remove rhizome, fibrous root and silt, dry.Hardship, is slightly cold.Return Liver Channel.
Cure mainly clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI,
Amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.
Radix Sophorae Flavescentis is the dry root of leguminous plant Radix Sophorae Flavescentis SophoraflavescensAit..GUIXIN, liver, stomach, big
Intestinal, bladder warp, have heat clearing and damp drying, effect of wind dispelling insecticide.Main damp-heat dysentery, discharging fresh blood stool, yellow
Subcutaneous ulcer, dysuria, edema, leukorrhagia, pudendal pruritus, scabies, leprosy, skin pruritus, noxious dampness skin infection.
Herbal medicine formula of the present invention is precise and appropriate, can effectively treat endometritis, have no side effect, cost
Cheap, provide a kind of new selection for clinical treatment endometritis.
Obviously, according to the foregoing of the present invention, according to ordinary technical knowledge and the customary means of this area,
Without departing under the present invention above-mentioned basic fundamental thought premise, it is also possible to make other various ways amendment,
Replace or change.
The detailed description of the invention of form by the following examples, remakes the foregoing of the present invention further
Detailed description.But this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to Examples below.
All technology realized based on foregoing of the present invention belong to the scope of the present invention.
Detailed description of the invention
The preparation of embodiment 1 herbal medicine of the present invention
Take Radix Sophorae Flavescentis 2 parts, Radix Paeoniae Rubra 1 part, 1 part of boiling of Caulis Trachelospermi 2 times, each 2 hours, concentrate
To every milliliter of 1g Han Chinese crude drug, add 95% ethanol to alcohol content and reach 65%, stand 12 hours, mistake
Filter, filtrate adds 95% ethanol makes alcohol content reach 75%, stands 12 hours, filters, and filtrate is volatilized
Ethanol is to without alcohol taste, for Chinese medicine extraction liquid；
Add Chinese medicine extraction liquid after dimethyl sulfoxide and glycerol being mixed, inject water to 100ml,
Stirring, dissolves, and 4 DEG C stand 72 hours, and 0.45 μm filtering with microporous membrane, subpackage, 121 DEG C damp and hot
Sterilizing 20 minutes, obtains uterus perfusion.
The preparation of embodiment 2 herbal medicine of the present invention
Take Radix Sophorae Flavescentis 1 part, Radix Paeoniae Rubra 1.5 parts, 1.5 parts of boilings of Caulis Trachelospermi 2 times, each 2 hours,
It is concentrated into every milliliter of 1g Han Chinese crude drug, adds 95% ethanol to alcohol content and reach 65%, stand 12 hours,
Filtering, filtrate adds 95% ethanol makes alcohol content reach 75%, stands 12 hours, filters, and filtrate is waved
Send out ethanol to without alcohol taste, for Chinese medicine extraction liquid；
Preparation: take Chinese medicine extraction liquid, adds adjuvant and makes suppository,.
The preparation of embodiment 3 herbal medicine of the present invention
Take Radix Sophorae Flavescentis 3 parts, Radix Paeoniae Rubra 0.5 part, 0.5 part of boiling of Caulis Trachelospermi 2 times, each 2 hours,
It is concentrated into every milliliter of 1g Han Chinese crude drug, adds 95% ethanol to alcohol content and reach 65%, stand 12 hours,
Filtering, filtrate adds 95% ethanol makes alcohol content reach 75%, stands 12 hours, filters, and filtrate is waved
Send out ethanol to without alcohol taste, for Chinese medicine extraction liquid；
Preparation: take Chinese medicine extraction liquid, adds adjuvant and makes drop,.
By the mode of experimental example beneficial effects of the present invention is described below:
The effect to endometritis of experimental example 1 herbal medicine of the present invention
One, experiment material
Take Radix Sophorae Flavescentis 2 parts, Radix Paeoniae Rubra 1 part, 1 part of boiling of Caulis Trachelospermi 2 times, each 2 hours, concentrate
To every milliliter of 1g Han Chinese crude drug, add 95% ethanol to alcohol content and reach 65%, stand 12 hours, mistake
Filter, filtrate adds 95% ethanol makes alcohol content reach 75%, stands 12 hours, filters, and filtrate is volatilized
Ethanol is to without alcohol taste, for Chinese medicine extraction liquid；Chinese medicine extraction is added after dimethyl sulfoxide and glycerol being mixed
Liquid, injects water to 100ml, stirring, dissolves, and 4 DEG C stand 72 hours, 0.45 μm micropore filter
Membrane filtration, subpackage, 121 DEG C of moist heat sterilizations 20 minutes, to obtain final product.
Two, application effect test
1 metritis diagnostic criteria
Slight: examination per rectum Uterus wall has and slightly thickens, one or both sides cornua uteri contractile response the most weak or
Contractile response is weak, flows out the little block secretions of white or mucus, floccule from vagina.
Moderate: examination per rectum Uterus wall has and substantially thickens, palace mound swelling being formed can be felt in palpation uterus
Irregular protuberantia, accumulation liquid in cavity of uterus, flow out from vagina white secretions or mucus is white,
Cotton-shaped.
Severe: examination per rectum Uterus wall has and substantially thickens, uterine volume increases and has obvious longitudinal furrow and grand
Convex, accumulation liquid in cavity of uterus, flows out white, pussy discharge from vagina.
2 experimental animals and packet
Choose 75 the first-borns time 1-3 parity, the age 3-5 year Postpartum Cows, per rectum inspection
Observe with uterine secretion physical property matter and be diagnosed as metritis.Test of cure group is divided into 3 groups by the state of an illness: slight
(40), moderate (20) and severe (15).
3 test methods
Using the method dispensing of uterine perfusion, offer medicine every day 1 50ml, is used in conjunction 3 times.After medication
Within 10 days, carrying out uterus examination per rectum, the cattle of recovery from illness stops treatment, the cattle continual cure do not cured.
Cure and judge: therapeutic effect is judged that the observation using examination per rectum and vaginal secretions judges:
The contractile response of uterus and cornua uteri is good, and uterus quality is soft, elastic good, vaginal secretions is limpid,
Without muddy for recovery from illness.
Three, experimental result
Result is as shown in table 1:
Table 1 therapeutic outcome
| Group | Test number | Cure number | Do not cure number | Cure rate (%) |
| Slightly | 40 | 37 | 3 | 92.5 |
| Moderate | 20 | 16 | 4 | 80.0 |
| Severe | 15 | 11 | 4 | 73.3 |
| Amount to | 75 | 64 | 11 | 85.3 |
From result, herbal medicine of the present invention can effectively treat endometritis, and average cure rate is up to
85.3%, the cure rate of slight endometritis is up to 92.5%, excellent effect.
To sum up, herbal medicine formula of the present invention is precise and appropriate, can effectively treat endometritis, and prepare work
Skill is simple, has no side effect, and application prospect is good.
Claims (10)
1. the herbal medicine being used for treating endometritis, it is characterised in that: it is to be joined by following weight
The preparation that the crude drug of ratio is prepared from: Radix Sophorae Flavescentis 1～3 parts, Radix Paeoniae Rubra 0.5～1.5 parts, Caulis Trachelospermi 0.5～1.5
Part.
Herbal medicine the most according to claim 1, it is characterised in that: it is by following weight proportion
The preparation that crude drug is prepared from: Radix Sophorae Flavescentis 2 parts, Radix Paeoniae Rubra 1 part, Caulis Trachelospermi 1 part.
Herbal medicine the most according to claim 1, it is characterised in that: it be the water by each raw material or/
It is active component with ethanol extraction, adds that adjuvant conventional in medicine or complementary composition are prepared from
Preparation.
Herbal medicine the most according to claim 3, it is characterised in that: described preparation is vagina administration system
Agent.
Herbal medicine the most according to claim 4, it is characterised in that: described vagina administration preparation is to fill
Fluid injection, lotion, suppository, drop, unguentum, powder.
Herbal medicine the most according to claim 5, it is characterised in that: described infusion liquid is uterine perfusion
Liquid.
7. preparing a method for herbal medicine described in claim 1-6 any one, it comprises the steps:
(1) each raw material is weighed by weight ratio；
(2) water of raw material is taken or/and ethanol extraction, auxiliary with what food, health product or medicine were commonly used
Material or complementary composition are prepared as preparation.
Method the most according to claim 7, it is characterised in that: the preparation method of described extract is:
Take Radix Sophorae Flavescentis, Radix Paeoniae Rubra, Caulis Trachelospermi, boiling, 2 times, each 2 hours, concentrate, in concentrated solution
Add ethanol to alcohol content and reach 65%, stand 12 hours, filter, then make to contain toward filtrate addition ethanol
Alcohol amount reaches 75%, stands 12 hours, filters, and volatilize ethanol,.
9. herbal medicine described in claim 1-6 any one is in the herbal medicine of preparation treatment endometritis
Purposes.
Purposes the most according to claim 9, it is characterised in that: the middle beast for the treatment of endometritis
Medicine is the herbal medicine for the treatment of cow endometritis.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610564986.4A CN105998220A (en) | 2016-07-18 | 2016-07-18 | Traditional Chinese veterinary material medicine for treating endometritis of cows as well as preparation method and use of traditional Chinese veterinary material medicine |
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| CN201610564986.4A CN105998220A (en) | 2016-07-18 | 2016-07-18 | Traditional Chinese veterinary material medicine for treating endometritis of cows as well as preparation method and use of traditional Chinese veterinary material medicine |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511464A (en) * | 2016-12-29 | 2017-03-22 | 成都乾坤动物药业股份有限公司 | Pharmaceutical composition for treating endometritis of female animals and preparation method of pharmaceutical composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101606992A (en) * | 2009-07-29 | 2009-12-23 | 北京大北农动物保健科技有限责任公司 | A kind of herbal mixture infusion liquid of preventing and treating cow endometritis and preparation method thereof |
| CN101991744A (en) * | 2010-11-22 | 2011-03-30 | 湖南省畜牧兽医研究所 | Traditional Chinese medicine perfusion agent for treating milk cow endometritis |
-
2016
- 2016-07-18 CN CN201610564986.4A patent/CN105998220A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101606992A (en) * | 2009-07-29 | 2009-12-23 | 北京大北农动物保健科技有限责任公司 | A kind of herbal mixture infusion liquid of preventing and treating cow endometritis and preparation method thereof |
| CN101991744A (en) * | 2010-11-22 | 2011-03-30 | 湖南省畜牧兽医研究所 | Traditional Chinese medicine perfusion agent for treating milk cow endometritis |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511464A (en) * | 2016-12-29 | 2017-03-22 | 成都乾坤动物药业股份有限公司 | Pharmaceutical composition for treating endometritis of female animals and preparation method of pharmaceutical composition |
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