CN105998137A - Channel dredging paste and preparation method for same - Google Patents
Channel dredging paste and preparation method for same Download PDFInfo
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- CN105998137A CN105998137A CN201610587960.1A CN201610587960A CN105998137A CN 105998137 A CN105998137 A CN 105998137A CN 201610587960 A CN201610587960 A CN 201610587960A CN 105998137 A CN105998137 A CN 105998137A
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Developmental Biology & Embryology (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses channel dredging paste and a preparation method for the same. The channel dredging paste is prepared from the following raw materials in parts by weight: 1 to 20 parts of angelica sinensis, 5 to 25 parts of ligusticum wallichii, 10 to 15 parts of cowherb seeds, 1 to 10 parts of liquidambar formosana hance and 5 to 10 parts of pangolins.
Description
Technical field
The invention belongs to pharmaceutical technology field, be specifically related to a kind of channels and collaterals dredging cream and preparation method thereof.
Background technology
Osteoarthritis, also known as osteoarthritis, degenerative osteoarthritis, hyperosteogeny, is commonly called as " bony spur ".Osteoarthritis belongs to the category that the traditional Chinese medical science " arthromyodynia ", " lumbago " etc. are sick.Western medical treatment is many with antiinflammation pain-stopping pharmaceutical, hyaluronate sodium intra-articular injection therapy, the glucocorticoid office envelope Therapeutic Method such as therapy, operative therapy.Chinese medicinal external application treatment osteoarthritis, functions dispelling wind and clearing away cold, removing dampness, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain often has preferable clinical efficacy.
Osteoarthritic condition can make the property of medicine enter space between skin and muscles, dredge the meridian passage from fur at muscle, joint, passages through which vital energy circulates etc. plaster outer plaster, more favourable one side of relatively taking medicine.Common plaster has:
(1) SHANGSHI ZHITONG GAO (rubber plaster): function wind dispelling cold expelling, eliminating dampness and dredging channels, promoting blood circulation and stopping pain.First skin warm water is cleaned during use and dry, be affixed on affected part, with palm, plaster massaged so that it is be bonded on skin.All to rubber plaster allergy, skin erosion has sepage person and wound to merge suppuration person, should not paste use.
Similar with its function also has Unguentum Moschus et Os Tigris, Qinghai Emplastrum Moschus, pain-relieving plaster for arthritis etc..
(2) dog skin plaster (plaster): function functions dispelling wind and clearing away cold, removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral pain relieving.During use, plaster is heated after softening, be affixed on affected part.
Similar with its function also has ten thousand spirit bone and muscle ointment, Herba Erodii cream etc., also can be selected for.
(3) military force is pulled out cold scattered (powder): function expelling wind and removing dampness, activates yang and invigorates blood circulation, alleviating pain and detumescence.Used time gets it filled in right amount, with Ovum Gallus domesticus album warm water slightly or human milk and medicine furnishing pasty state, is split on paraffin paper, is affixed on acupuncture point or affected part.Note during use avoiding cold and uncooked food, not oral administration.Unavailable washing in 10 days at skin paste medicine.Umbilicus wheel, arch of the foot etc. not can be used on the lining.Child, weak and edema person avoid use.
(4) five tigers dissipate (powder): it is same that cold dephasing is pulled out in function and military force, mixes well with Chinese liquor, spread on affected part during use.Except apply outside, this dissipates also oral administration.6g every time, with temperature yellow wine or warm water delivery service.
Above-mentioned plaster is respectively provided with certain limitation, function singleness, takes effect slow, and the shortcoming of curative effect length, patient expects that more preferable plaster appears on the market.
Summary of the invention
For deficiency of the prior art, it is an object of the invention to provide the technical issues that need to address of the present invention and be that the defect overcoming prior art, it is provided that a kind of channels and collaterals dredging cream and preparation method thereof.
To achieve these goals, the present invention adopts the technical scheme that:
A kind of channels and collaterals dredging cream, material component and the weight proportion of described channels and collaterals dredging cream be: Radix Angelicae Sinensis 1-20 part, Rhizoma Chuanxiong 5-25 part, Semen Vaccariae 10-15 part, Fructus Liquidambaris 1-10 part, Squama Manis 5-10 part.
Material component and the weight proportion of described channels and collaterals dredging cream be: Radix Angelicae Sinensis 1 part, Rhizoma Chuanxiong 5 parts, Semen Vaccariae 10 parts, Fructus Liquidambaris 1 part, Squama Manis 5 parts.
Material component and the weight proportion of described channels and collaterals dredging cream be: Radix Angelicae Sinensis 20 parts, Rhizoma Chuanxiong 25 parts, Semen Vaccariae 15 parts, Fructus Liquidambaris 10 parts, Squama Manis 10 parts.
Material component and the weight proportion of described channels and collaterals dredging cream be: Radix Angelicae Sinensis 16 parts, Rhizoma Chuanxiong 8 parts, Semen Vaccariae 13 parts, Fructus Liquidambaris 9 parts, Squama Manis 7 parts.
Described method comprises the steps:
Step one, weigh raw material by proportioning raw materials；
Step 2, boiling secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into relative density and surveys the thick paste of 1.34-1.37 in 80 DEG C, after stirring, receives cream, then papering；
Step 3, with being placed on after the compacting of 60 centimeters of models, dressing is fixing to be sticked, and to obtain final product, and a diameter of 8cm of finished product paste made, it is 10cm × 10cm that the specification of patch is fixed in dressing.
Radix Angelicae Sinensis: for the root of umbelliferae angelica；Nature and flavor with return through: temperature, sweet, pungent.Return liver, the heart, spleen channel；Function with cure mainly: replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Rhizoma Chuanxiong: for the dry rhizome of samphire Rhizoma Chuanxiong；Nature and flavor with return through: pungent, temperature.Return liver, gallbladder, pericardium channel；Function with cure mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For pacifying nerve, the headache of positive wind syndrome of head, lump in the abdomen stomachache, the breast side of body twinge, tumbling and swelling, headache, rheumatic arthralgia.
Squama Manis: for the scale of Manidae animal Manitis；Nature and flavor with return through: salty, be slightly cold.Return liver, stomach warp；Function with cure mainly: blood circulation promoting and dispersing pathogen accumulation, stimulating milk secretion of stimulating the menstrual flow, eliminating carbuncle burst heavily fortified point.For blood stasis amenorrhea, lump in the abdomen, rheumatic arthralgia, agalactia, carbuncle, scrofula.
Semen Vaccariae: for the dry mature seed of dicotyledon Caryophyllaceae Vaccaria segetalis；Nature and flavor with return through: bitter, flat.Return liver, stomach warp.Function with cure mainly: promoting blood circulation to restore menstrual flow, stimulating milk secretion eliminating carbuncle, inducing diuresis for treating stranguria syndrome.Swell and ache for blood stasis amenorrhea, dysmenorrhea, difficult labour, lack of lactation after delivery, acute mastitis, pyretic stranguria, stranguria with blood, stranguria caused by urinary stone etc..
Fructus Liquidambaris: for the drying and ripening infructescence of Hamamelidaceae Plants Chinese sweet gum；Nature and flavor with return through: bitter, flat.Return liver, kidney channel；Function with cure mainly: dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.
Detailed description of the invention
Embodiment
1
A kind of channels and collaterals dredging cream, material component and the weight proportion of described channels and collaterals dredging cream be: Radix Angelicae Sinensis 1 part, Rhizoma Chuanxiong 5 parts, Semen Vaccariae 10 parts, Fructus Liquidambaris 1 part, Squama Manis 5 parts.
Embodiment
2
A kind of channels and collaterals dredging cream, material component and the weight proportion of described channels and collaterals dredging cream be: Radix Angelicae Sinensis 20 parts, Rhizoma Chuanxiong 25 parts, Semen Vaccariae 15 parts, Fructus Liquidambaris 10 parts, Squama Manis 10 parts.
Embodiment
3
Material component and the weight proportion of described channels and collaterals dredging cream be: Radix Angelicae Sinensis 16 parts, Rhizoma Chuanxiong 8 parts, Semen Vaccariae 13 parts, Fructus Liquidambaris 9 parts, Squama Manis 7 parts.
Pharmacology pharmacodynamic is tested, and animal is Kunming white mice, and body weight 24-27g is female.
Test method and result
One, the channels and collaterals dredging cream impact on animal
Acute toxicity test, takes Kunming male mice 20, fasting 12 hours, gavage ointment, every day time, observed through 7 days and raise, occur without dead, also no abnormality seen reaction.
Long term toxicity test
With 7 week old wistar female rats as subjects, it is randomly divided into matched group by body weight, low dose group 1.35g/k9 (dosage is equivalent to people one consumption per day rat equivalent), high dose group 19.5g/kg 15 times of people one consumption per day rat equivalent (dosage be equivalent to), transvaginal successive administration 10 weeks.
Observing through general behavior sign, each dosage group, each time, each test example are showed no Deviant Behavior sign, the weight of animals rapid development, physically well develop.
Through test each dosage group routine blood test in latter stage, liver function, the detection of renal function, being showed no significant difference between examined indices group, all in the range of biological value, single test example is also without the exceptional value beyond physiological range.Becoming celestial and organ coefficient calculating through test each dosage group system in latter stage, each group is showed no macroscopic pathological change.Organ coefficient respectively organize between also unknown significance difference, all in the range of biological value, single test example is also without the exceptional value beyond physiological range.Through test latter stage each dosage group each main organs tectology check, each group, each test example be showed no abnormal structure's form.
In sum, show that ointment does not cause toxicity to long poison rat.
Clinical observation on the therapeutic effect:
Case one
Deng XX, man, people from Hebei, 50 years old, there is whole body paralysis without any obvious inducement before 2 years in patient, gives plaster of the present invention, external, is affixed on affected part, and one time one patch, 2 once.After treating 2 days, paralysis symptom is substantially alleviated, and after 7 days, paralysis symptom disappears substantially.
Case two
XX, man, 35 years old, there is lumbago before 5 years in patient, after gradually increase the weight of.Increase the weight of in cause fatigue in January pain, movable unfavorable, certainly take ibuprofen and do not feel any better, then award plaster of the present invention, external in June, 2008, be affixed at either side of the small of the back, after treating 1 week, lumbago symptom disappears substantially.
Case three
XX, female, 65 years old, patient suffered from rheumatoid before 3 years, after gradually increase the weight of.After treating 1 month in February, 2006, getting better and turn, recur again after stopping treatment, in JIUYUE, 2006 awards plaster of the present invention, external, is affixed at the sea of blood, and after treating 1 week, rheumatoid symptom is substantially eased, and after treating 10 days, rheumatoid symptom disappears substantially, does not recurs so far.
The medicine of the present invention be based on:
Monarch drug is Squama Manis, has hard masses softening and resolving effect, ministerial drug Radix Angelicae Sinensis, Rhizoma Chuanxiong, blood circulation promoting and blood stasis dispelling, and promoting the flow of QI in the collateral by warming the meridian eliminates the phlegm wet.Help with Semen Vaccariae dispel pain spasmolytic.With Fructus Liquidambaris for making medicine.All medicines share, then have hard masses softening and resolving, blood circulation promoting and blood stasis dispelling, the effect of removing obstruction in the collateral to relieve pain.Because it has " year that disappears, deep hard knot was stagnant, broken blood coagulation with the passing of time " effect, therefore the absorption of hypertrophy sclerotin can be promoted.
It is last that it is noted that obviously above-described embodiment is only for clearly demonstrating the application example, and not restriction to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here without also cannot all of embodiment be given exhaustive.And among the obvious change thus amplified out or the variation protection domain still in the application type.
Claims (5)
1. a channels and collaterals dredging cream, it is characterised in that material component and the weight proportion of described channels and collaterals dredging cream be: Radix Angelicae Sinensis 1-20 part, Rhizoma Chuanxiong 5-25 part, Semen Vaccariae 10-15 part, Fructus Liquidambaris 1-10 part, Squama Manis 5-10 part.
Channels and collaterals dredging cream the most according to claim 1, it is characterised in that material component and the weight proportion of described channels and collaterals dredging cream be: Radix Angelicae Sinensis 1 part, Rhizoma Chuanxiong 5 parts, Semen Vaccariae 10 parts, Fructus Liquidambaris 1 part, Squama Manis 5 parts.
Channels and collaterals dredging cream the most according to claim 1, it is characterised in that material component and the weight proportion of described channels and collaterals dredging cream be: Radix Angelicae Sinensis 20 parts, Rhizoma Chuanxiong 25 parts, Semen Vaccariae 15 parts, Fructus Liquidambaris 10 parts, Squama Manis 10 parts.
Channels and collaterals dredging cream the most according to claim 1, it is characterised in that material component and the weight proportion of described channels and collaterals dredging cream be: Radix Angelicae Sinensis 16 parts, Rhizoma Chuanxiong 8 parts, Semen Vaccariae 13 parts, Fructus Liquidambaris 9 parts, Squama Manis 7 parts.
5. the preparation method of channels and collaterals dredging cream described in a claim 1, it is characterised in that described method comprises the steps:
Step one, weigh raw material by proportioning raw materials；
Step 2, boiling secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into relative density and surveys the thick paste of 1.34-1.37 in 80 DEG C, after stirring, receives cream, then papering；
Step 3, with being placed on after the compacting of 60 centimeters of models, dressing is fixing to be sticked, and to obtain final product, and a diameter of 8cm of finished product paste made, it is 10cm × 10cm that the specification of patch is fixed in dressing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610587960.1A CN105998137A (en) | 2016-07-25 | 2016-07-25 | Channel dredging paste and preparation method for same |
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| CN201610587960.1A CN105998137A (en) | 2016-07-25 | 2016-07-25 | Channel dredging paste and preparation method for same |
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| CN105998137A true CN105998137A (en) | 2016-10-12 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011491A (en) * | 2007-01-24 | 2007-08-08 | 辽宁好护士药业（集团）有限责任公司 | Granule for expelling obstruction of galactophore and its preparation method |
| CN101129946A (en) * | 2007-09-17 | 2008-02-27 | 吴兴保 | Wet rheumatalgia-relieving plaster for traumatic injury and method of producing the same |
-
2016
- 2016-07-25 CN CN201610587960.1A patent/CN105998137A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011491A (en) * | 2007-01-24 | 2007-08-08 | 辽宁好护士药业（集团）有限责任公司 | Granule for expelling obstruction of galactophore and its preparation method |
| CN101129946A (en) * | 2007-09-17 | 2008-02-27 | 吴兴保 | Wet rheumatalgia-relieving plaster for traumatic injury and method of producing the same |
Non-Patent Citations (1)
| Title |
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| 陈暖: "《很老很老的老偏方大全集》", 31 August 2012, 山西科学技术出版社 * |
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