CN105998122A - Analgesic use of Vernonia amygdalina water extract, preparation method and preparation thereof - Google Patents
Analgesic use of Vernonia amygdalina water extract, preparation method and preparation thereof Download PDFInfo
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- CN105998122A CN105998122A CN201610624945.XA CN201610624945A CN105998122A CN 105998122 A CN105998122 A CN 105998122A CN 201610624945 A CN201610624945 A CN 201610624945A CN 105998122 A CN105998122 A CN 105998122A
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- 239000000284 extract Substances 0.000 title claims abstract description 76
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 74
- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- 230000000202 analgesic effect Effects 0.000 title claims abstract description 15
- 235000004109 Gymnanthemum amygdalinum Nutrition 0.000 title abstract description 8
- 241001635503 Gymnanthemum amygdalinum Species 0.000 title abstract description 8
- 238000003809 water extraction Methods 0.000 claims abstract description 22
- 244000144725 Amygdalus communis Species 0.000 claims description 100
- 235000011437 Amygdalus communis Nutrition 0.000 claims description 100
- 241000736800 Vernonia Species 0.000 claims description 100
- 235000020224 almond Nutrition 0.000 claims description 100
- 239000000843 powder Substances 0.000 claims description 34
- 239000000706 filtrate Substances 0.000 claims description 10
- 239000006187 pill Substances 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 6
- 235000007516 Chrysanthemum Nutrition 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 4
- 241001504624 Streptopelia Species 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- -1 teabag Substances 0.000 claims description 2
- 244000189548 Chrysanthemum x morifolium Species 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract description 12
- 208000000114 Pain Threshold Diseases 0.000 abstract description 11
- 230000037040 pain threshold Effects 0.000 abstract description 11
- 238000000034 method Methods 0.000 abstract description 10
- 239000004480 active ingredient Substances 0.000 abstract 4
- 239000007928 intraperitoneal injection Substances 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 13
- 230000000694 effects Effects 0.000 description 11
- 230000036592 analgesia Effects 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 230000000144 pharmacologic effect Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 241000723353 Chrysanthemum Species 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000008964 yuanhu zhitong Substances 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- FZALQGCQQJLGKE-BBNZOYGDSA-N Vernodalol Chemical compound C=C1C(=O)OC[C@@]2(C=C)C[C@H](OC(=O)C(=C)CO)[C@@H](C(=C)C(=O)OC)[C@H](O)[C@H]21 FZALQGCQQJLGKE-BBNZOYGDSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- FZALQGCQQJLGKE-UHFFFAOYSA-N vernodalol Natural products C=C1C(=O)OCC2(C=C)CC(OC(=O)C(=C)CO)C(C(=C)C(=O)OC)C(O)C21 FZALQGCQQJLGKE-UHFFFAOYSA-N 0.000 description 2
- 241000208838 Asteraceae Species 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241000233805 Phoenix Species 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The invention relates to a preparation method of a Vernonia amygdalina water extract active ingredient and analgesic use. The method includes: crushing Vernonia amygdalina leaf and performing water extraction to obtain the Vernonia amygdalina water extract active ingredient. The Vernonia amygdalina water extract active ingredient can significantly increase the mouse pain threshold and reduce the frequency of writhing reaction caused by intraperitoneal injection of 0.6% acetic acid, and the Vernonia amygdalina water extract active ingredient has good analgesic effect.
Description
Technical field
The present invention relates to technical field of natural product extraction, especially a kind of almond Herba Vernonia esculenta water carries
Take the preparation method of thing active component, and almond Herba Vernonia esculenta water extract active component is for town
The purposes of pain and the application in preparing health product, food.
Background technology
Almond Herba Vernonia esculenta (Classification system: Vernonia amygdalina Del.), for Compositae Strepopelia orientalis
Dendranthema, calls as South Africa leaf, Folium Persicae Herba Vernonia esculenta, Folium Pruni Herba Vernonia esculenta, magical leaf, fine stern
Phoenix, liver company, bitter tree, gall bladder leaf, bitter leaf, Folium Ligustri pubescentis, South Africa tree etc., originate in Tropical Africa,
It is distributed widely in the African Territories, equator of Sub-Sahara, is typically grown in close to water source
Grassland and forest area, it is also possible to be grown in height above sea level and be up to the area of 2000 meters, need abundance
Sunlight, although relatively more drought-enduring, but preferably grow in a humid environment.
Summary of the invention
The technical issues that need to address of the present invention are to provide a kind of almond Herba Vernonia esculenta water extract and live
Property composition preparation method and analgesia purposes.Pain threshold can be improved, there is preferable analgesic activities,
Can be as analgesic.
For solving above-mentioned technical problem, the technical solution adopted in the present invention is:
The invention discloses almond Herba Vernonia esculenta water extract for analgesic purposes.
The invention also discloses the preparation method of almond Herba Vernonia esculenta water extract, including following technique
Step,
Step 1) pulverize, almond Herba Vernonia esculenta is ground into coarse powder；
Step 2) water extraction, by the boiling of almond Herba Vernonia esculenta coarse powder elder generation several times, filter,
Obtain water extraction filtrate and water extraction filtering residue；
Step 3) concentrate, water extraction filtrate is concentrated in vacuo, obtains containing almond Strepopelia orientalis
The extractum of chrysanthemum water extract active component.
Further improvement is that of technical solution of the present invention: described step 1) in almond Herba Vernonia esculenta
The granularity of coarse powder is 10～60 mesh.
Further improvement is that of technical solution of the present invention: described step 2) in water and almond speckle
The mass ratio of turtledove chrysanthemum coarse powder is 4:1～10:1, and decoction number of times 2～5 times, each decocting time is
1～4h.
Further improvement is that of technical solution of the present invention: described step 3) in be concentrated in vacuo
Temperature is 30～60 DEG C, and vacuum is-0.1Mpa, is concentrated in vacuo and obtains relative density 1.01～1.40
Extractum.
The invention also discloses the preparation containing almond Herba Vernonia esculenta water extract, described preparation contains
Having almond Herba Vernonia esculenta water extract active component, the dosage form of described preparation includes granule, capsule
Agent, tablet, powder, soft extracts, pill, oral liquid, teabag, drop pill, ointment, bolt
Agent, injection, effervescent.
Further improvement is that of technical solution of the present invention: described almond Herba Vernonia esculenta water extract is true
It is 2～6% that sky is dried to moisture, is ground into the coarse powder of 10～30 mesh, then is made accordingly by coarse powder
Dosage form.
Owing to have employed technique scheme, the technological progress that the present invention obtains is:
The present invention gives the preparation method of almond Herba Vernonia esculenta water extract active component, by right
The pharmacological evaluation of almond Herba Vernonia esculenta water extract active component is it was confirmed almond Herba Vernonia esculenta water extraction
Thing active component has analgesic effect, has significant effect to analgesia, and the present invention also gives simultaneously
Go out the preparation containing almond Herba Vernonia esculenta water extract active component.It is bright that the present invention also has curative effect
Really, with low cost, production technology is simple and the feature such as taking convenience.
The preparation method of the almond Vernodalol extract active component of the present invention, it is possible to efficiently
Active component in almond Herba Vernonia esculenta is extracted, almond Herba Vernonia esculenta water extract active component
The analgesia efficacy of a drug and the drug effect that can make almond Herba Vernonia esculenta are preferably brought into play.By to almond speckle
The pharmacological evaluation of turtledove chrysanthemum water extract active component is it was confirmed almond Herba Vernonia esculenta water extract is active
Composition has analgesic effect, has significant effect to analgesia.
The present invention is by mice pain threshold and writhing response number of times pharmacological evaluation, it was observed that almond
Vernodalol water extract active component can significantly improve mice pain threshold and reduce lumbar injection
The writhing response number of times that 0.6% acetic acid causes.Almond Herba Vernonia esculenta water extract active component has relatively
Good analgesic activity.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further details:
Embodiment 1
The preparation of almond Herba Vernonia esculenta water extract active component.
Preparing almond Herba Vernonia esculenta water extract active component in the present embodiment, the raw material of employing is flat
Fructus Persicae Herba Vernonia esculenta is dried blade, first almond Herba Vernonia esculenta is dried blade and cleans process, specifically
Be placed in clean on operating board for almond Herba Vernonia esculenta being dried blade, pick clean impurity, foreign body, damage by worms,
Go mouldy and dis-medicinal part, obtain cleaning qualified raw material.
The concrete preparation method of almond Herba Vernonia esculenta water extract activity in the present embodiment, including following
Processing step:
Step 1-1) pulverize, almond Herba Vernonia esculenta is ground into coarse powder, almond Herba Vernonia esculenta is dried
Leaf is placed in pulverizer, is ground into the coarse powder that granularity is 10～30 mesh.
Step 1-2) water extraction, almond Herba Vernonia esculenta coarse powder is placed in multi-function extractor, presses
Mass ratio according to water Yu almond Herba Vernonia esculenta coarse powder is 4:1, and boiling 2 times, when decocting every time
Between be 3h, filter, obtain water extraction filtrate and water extraction filtering residue.
Step 1-3) concentrate, first water extraction filtrate is placed in ultralow temperature thickener, in temperature
Be 30 DEG C, vacuum be concentrated in vacuo under conditions of-0.1Mpa, obtain relative density
The extractum of 1.01～1.40.
Embodiment 2
The preparation of almond Herba Vernonia esculenta water extract active component.
Preparing almond Herba Vernonia esculenta water extract active component in the present embodiment, the raw material of employing is flat
Fructus Persicae Herba Vernonia esculenta is dried blade, first almond Herba Vernonia esculenta is dried blade and cleans process, specifically
Be placed in clean on operating board for almond Herba Vernonia esculenta being dried blade, pick clean impurity, foreign body, damage by worms,
Go mouldy and dis-medicinal part, obtain cleaning qualified raw material.
The concrete preparation method of almond Herba Vernonia esculenta water extract active component in the present embodiment, including
Following processing step:
Step 1-1) pulverize, almond Herba Vernonia esculenta is ground into coarse powder, almond Herba Vernonia esculenta is dried
Leaf is placed in pulverizer, is ground into the coarse powder that granularity is 20～50 mesh.
Step 1-2) water extraction, almond Herba Vernonia esculenta coarse powder is placed in multi-function extractor, presses
Mass ratio according to water Yu almond Herba Vernonia esculenta coarse powder is 6:1, and boiling 5 times, when decocting every time
Between be 1h, filter, obtain water extraction filtrate and water extraction filtering residue.
Step 1-3) concentrate, first water extraction filtrate is placed in ultralow temperature thickener, in temperature
Be 45 DEG C, vacuum be concentrated in vacuo under conditions of-0.1Mpa, obtain relative density
The extractum of 1.01～1.40.
Embodiment 3
The preparation of almond Herba Vernonia esculenta water extract active component.
Preparing almond Herba Vernonia esculenta water extract active component in the present embodiment, the raw material of employing is flat
Fructus Persicae Herba Vernonia esculenta is dried blade, first almond Herba Vernonia esculenta is dried blade and cleans process, specifically
Be placed in clean on operating board for almond Herba Vernonia esculenta being dried blade, pick clean impurity, foreign body, damage by worms,
Go mouldy and dis-medicinal part, obtain cleaning qualified raw material.
The concrete preparation method of almond Herba Vernonia esculenta water extract active component in the present embodiment, including
Following processing step:
Step 1-1) pulverize, almond Herba Vernonia esculenta is ground into coarse powder, almond Herba Vernonia esculenta is dried
Leaf is placed in pulverizer, is ground into the coarse powder that granularity is 40～60 mesh.
Step 1-2) water extraction, almond Herba Vernonia esculenta coarse powder is placed in multi-function extractor, presses
Mass ratio according to water Yu almond Herba Vernonia esculenta coarse powder is 10:1, and boiling 3 times, when decocting every time
Between be 3h, filter, obtain water extraction filtrate and water extraction filtering residue.
Step 1-3) concentrate, first water extraction filtrate is placed in ultralow temperature thickener, in temperature
Be 60 DEG C, vacuum be concentrated in vacuo under conditions of-0.1Mpa, obtain relative density
The extractum of 1.01～1.40.
Embodiment 4
The preparation of the granule containing almond Herba Vernonia esculenta water extract active component.
The present embodiment uses the almond Herba Vernonia esculenta water extract activity prepared in embodiment 1
Granule prepared by composition extractum, is first vacuum dried by almond Herba Vernonia esculenta water extract active component
Be 2% to moisture, be ground into the coarse powder of 10～20 mesh, then using coarse powder as main material with corresponding
Adjuvant mixing, carry out pelletize after mixing, make corresponding containing almond Herba Vernonia esculenta water extract
The granule of activity.
Embodiment 5
The preparation of the capsule containing almond Herba Vernonia esculenta water extract active component.
The present embodiment uses the almond Herba Vernonia esculenta water extract activity prepared in embodiment 2
Capsule prepared by composition extractum, is first vacuum dried by almond Herba Vernonia esculenta water extract active component
Be 6% to moisture, be ground into the coarse powder of 20～30 mesh, then using coarse powder as main material with corresponding
Adjuvant mixing, carry out pelletize after mixing, load in capsule after pelletize, make and contain accordingly
The capsule of almond Herba Vernonia esculenta water extract active component.
Embodiment 6
The preparation of the tablet containing almond Herba Vernonia esculenta water extract active component.
The present embodiment uses the almond Herba Vernonia esculenta water extract activity prepared in embodiment 1
Tablet prepared by composition extractum, is first dried under vacuum to by almond Herba Vernonia esculenta water extract active component
Moisture is 4%, is ground into the coarse powder of 15～25 mesh, then using coarse powder as main material with corresponding
Adjuvant mixes, and carries out pelletize, carry out tabletting after pelletize after mixing, makes corresponding containing almond
The tablet of Herba Vernonia esculenta water extract active component.
Embodiment 7
The preparation of the pill containing almond Herba Vernonia esculenta water extract active component.
The present embodiment uses the almond Herba Vernonia esculenta water extract activity prepared in embodiment 2
Concentrated pill prepared by composition extractum, first almond Herba Vernonia esculenta water extract active component vacuum is done
Dry is 6% to moisture, is ground into the coarse powder of 20～30 mesh, then using coarse powder as main material and phase
The adjuvant mixing answered, carries out pelletize, is twisted into pill, makes and contain accordingly after pelletize after mixing
The pill of almond Herba Vernonia esculenta water extract active component.
Embodiment 8
Almond Herba Vernonia esculenta water extract active component pharmacological evaluation.
Employing SPF level health kunming mice 100 in the present embodiment, body weight (25 ± 2) g,
Credit number SCXK (capital) 2014-0004, quality certification numbering: 1140130034805, it is purchased from
Beijing HFK Bio-Technology Co., Ltd..YUANHU ZHITONG PIAN (batch number: 1507003,
Taiji Group Sichuan Mianyang Pharmaceutical Co., Ltd.).
After mice adaptability feeds 1 week, being randomly divided into 5 groups, often 20 mices of group, are divided into
YUANHU ZHITONG PIAN group, almond Herba Vernonia esculenta extract low dose group is administered the flat of 1.14g/kg/d dosage
Fructus Persicae Herba Vernonia esculenta extract, in almond Herba Vernonia esculenta extract, dosage group is administered 2.28g/kg/d dosage
Almond Herba Vernonia esculenta extract, almond Herba Vernonia esculenta extract high dose group is administered 4.56g/kg/d dosage
Almond Herba Vernonia esculenta extract.Normal saline group gavage equal-volume normal saline, persistently gives for each group
Medicine 3 days, after 3 days, often group takes 10 mices and carries out hot plate method analgesic experiment, and often group takes 10
Mice carries out writhing method analgesic experiment.
Hot plate method experimental technique: set up hot-plate instrument (YLS-6B type intelligence hot-plate instrument) temperature and make
Be constant at 55 ± 0.5 DEG C, take mice, be placed on hot-plate instrument, by " beginning " key record time.
From putting into the pain threshold that hot-plate instrument to mice occurs licking the time (second) needed for metapedes as this Mus
(second), pain threshold is the highest, and analgesic effect is the best.
Writhing method experimental technique: the 0.6% acetic acid 0.2ml/ that the equal lumbar injection of each mice is newly prepared
Only, occurring the number of times of writhing response in observing each mice 15min, writhing number of times is the fewest, analgesia
Effect is the best.
Specific experiment result is as follows:
1, the almond Herba Vernonia esculenta water extract impact on mice pain threshold
Before each treated animal is administered, pain threshold does not has significant difference；After administration, with normal saline group
Relatively, YUANHU ZHITONG PIAN group and almond Herba Vernonia esculenta water extract each dosage group have significant difference (P
＜ 0.01, P ＜ 0.05), analgesia high with almond Herba Vernonia esculenta water extract high dose group pain threshold
Effective.
The impact (s) on mice pain threshold of the table 1 almond Herba Vernonia esculenta water extract
Note: compare with normal saline group△P ＜ 0.05,△△P ＜ 0.01.
The impact on mouse writhing number of times of the 2 almond Herba Vernonia esculenta water extract
Before each treated animal is administered, writhing number of times does not has significant difference；After administration, with normal saline
Group compares, and YUANHU ZHITONG PIAN group and almond Herba Vernonia esculenta water extract each dosage group have significant difference
(P ＜ 0.01, P ＜ 0.05), few with almond Herba Vernonia esculenta water extract high dose group writhing number of times,
Analgesic effect is good.
The impact on mouse writhing number of times of the table 2 almond Herba Vernonia esculenta water extract
Note: compare with normal saline group△P ＜ 0.05,△△P ＜ 0.01.
The present invention is studied by animal pharmacological experiment, obtains ideal effect, obtains following main knot
Opinion: the almond Herba Vernonia esculenta water extract active component of the present invention can improve the pain threshold of mice, fall
The writhing response number of times that low lumbar injection 0.6% acetic acid causes, shows that almond Herba Vernonia esculenta has relatively
Good analgesic activity.
Claims (7)
1. almond Herba Vernonia esculenta water extract is used for analgesic purposes.
2. the preparation method of almond Herba Vernonia esculenta water extract, it is characterised in that: comprise the following steps that,
Step 1) pulverize, almond Herba Vernonia esculenta is ground into coarse powder；
Step 2) water extraction, by the boiling of almond Herba Vernonia esculenta coarse powder elder generation several times, filters, obtains water extraction
Filtrate and water extraction filtering residue；
Step 3) concentrate, water extraction filtrate is concentrated in vacuo, obtains containing almond Herba Vernonia esculenta water extract
The extractum of active component.
The preparation method that almond Herba Vernonia esculenta water extract the most according to claim 2 divides, it is characterised in that:
Described step 1) in the granularity of almond Herba Vernonia esculenta coarse powder be 10～60 mesh.
The preparation method of almond Herba Vernonia esculenta water extract the most according to claim 2, it is characterised in that:
Described step 2) in the mass ratio of water and almond Herba Vernonia esculenta coarse powder be 4:1～10:1, decoct number of times 2～5 times, often
Secondary decocting time is 1～4h.
The preparation method of almond Herba Vernonia esculenta water extract the most according to claim 2, it is characterised in that:
Described step 3) in the temperature that is concentrated in vacuo be 30～60 DEG C, vacuum is-0.1Mpa, is concentrated in vacuo and obtains
The extractum of relative density 1.01～1.40.
6. contain the preparation of almond Herba Vernonia esculenta water extract, it is characterised in that: containing almond speckle in described preparation
Turtledove chrysanthemum water extract active component, the dosage form of described preparation include granule, capsule, tablet, powder,
Soft extracts, pill, oral liquid, teabag, drop pill, ointment, suppository, injection, effervescent.
Preparation containing almond Herba Vernonia esculenta water extract the most according to claim 6, it is characterised in that:
It is 2～6% that described almond Herba Vernonia esculenta water extract is dried under vacuum to moisture, is ground into the coarse powder of 10～30 mesh, then
Coarse powder is made corresponding dosage form.
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| CN105285256A (en) * | 2015-11-23 | 2016-02-03 | 福建农林大学 | Vernoniaamygdalina Del. leaf tea composition and preparation method thereof |
-
2016
- 2016-08-02 CN CN201610624945.XA patent/CN105998122A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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