CN105997991A - Development and application of health and functional active salt substance with acarid killing and expelling effects - Google Patents

Development and application of health and functional active salt substance with acarid killing and expelling effects Download PDF

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Publication number
CN105997991A
CN105997991A CN201610565439.8A CN201610565439A CN105997991A CN 105997991 A CN105997991 A CN 105997991A CN 201610565439 A CN201610565439 A CN 201610565439A CN 105997991 A CN105997991 A CN 105997991A
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demodicid mite
active salt
arteannuin
product
healthy functions
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辛成业
何广义
苗艳
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2096—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Birds (AREA)
  • Dentistry (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention belongs to the field of research and development of bioactive substances (including medicines) as well as health substances and products thereof, and relates to a bioactive substance (including a medicine) and a health substance, particularly to a health and functional active salt substance with acarid killing and expelling effects and application thereof. The health and functional active salt substance is artemisinin and a derivative thereof as well as relative substances (including but not limited to: artemisinin, dihydroartemisinin, artesunate, artemether, arteether, a C12 derivative of artemisinin, a C4 derivative of artemisinin, steroid artemisinin, open-loop artemisinin, an artemisinin structure simplified substance and the like) existing in the form of salts; due to pharmacodynamics tests, the bioactive and health substance with the acarid killing and expelling effects is obtained, and can be applied to products such as medicines, health care products, health products, personal care products (infant care articles), household cleansers, pet cleansers, agricultural gardening articles and acarid prevention fabrics in the market.

Description

A kind of exploitation with the active salt healthy functions material going out demodicid mite and drive demodicid mite effect and application thereof
Technical field
The invention belongs to bioactive substance (including medicine) and healthy material and goods research and development field thereof, relate to one Plant bioactive substance (including medicine) and healthy material, particularly to a kind of active salt having and going out demodicid mite with drive demodicid mite effect Healthy functions material and application thereof.
Background technology
Demodicid mite class is to be under the jurisdiction of the animal that a class build of Arthropoda Arachnoidea Acari is small, is except Ticks in Acari The general designation of all kinds beyond class.The most most common is also the mankind to endanger maximum be mainly flour mite, dust mite and vermiform mite. Acarid not only can contaminated food and room health, initiation asthma that also can be direct or indirect, allergy, the multiple disease such as acne, And grain, medical material can be polluted, cause house pet disease, therefore for acarid kill with drive away the most necessary.Although at present It is various that demodicid mite of going out on the market drives demodicid mite product category, but toxicity is relatively strong mostly, has potential hazard to health, and has dirt The danger of dye environment, therefore develop a kind of environmentally friendly, low toxicity goes out efficiently, and to drive demodicid mite product extremely urgent for demodicid mite.
Arteannuin derives from feverfew Herba Artemisiae Annuae and Herba Artemisiae annuae, has the potent antimalarial active that pharmacological mechanism is unique, blue or green at present Artemisin and derivant thereof are the malaria one line medications of the world today, and are widely deployed utilization, can be used for treating autoimmune Disease, controls algae and water pollution etc..Within 2015, slaughter cry of a deer researcher and obtain Nobel prize's soul because of arteannuin, More indicate the world to arteannuin and the accreditation of derivant thereof, be also that China's Chinese Traditional Medicine culture is recognized, be Chinese The solid strong step that TCM Culture is walked out, has landmark meaning.Arteannuin and derivant thereof are with relevant Thing has the demodicid mite and drive demodicid mite effect, the present inventor's patent applied for (application number: 201610373894.8), but arteannuin of going out Constituents dissolubility is poor, and preparation process requires higher, and for those reasons, what a kind of dissolubility was good go out, and demodicid mite drives demodicid mite product In the urgent need to.In conjunction with actual production, the present inventor applies with the form of artemisine composition salt, the way of concrete one-tenth salt Routing method is not intended to, all in protection domain.By arteannuin and derivant thereof and correlative with monomeric compound or compositions Carry out pharmacodynamics checking with the form of active salt, obtain there is the active salt healthy functions material going out demodicid mite and drive demodicid mite effect with strong Health material, thus advance the innovation of medicine and health-oriented products, and and daily life healthy to people is produced deep Remote impact.
Summary of the invention
First purpose of the present invention is to provide a kind of active salt healthy functions material having and going out demodicid mite with drive demodicid mite effect, this Invent described active salt healthy functions material refer to arteannuin and derivant thereof and correlative (include but not limited to, arteannuin, Dihydroarteannuin, artesunate, Artemether, arteether, arteannuin C12Derivant, arteannuin C4Derivant, steroid Arteannuin, open loop arteannuin, arteannuin structure simplifies thing etc.) exist in a salt form.Described active salt healthy functions thing Matter can obtain through any approach, include but not limited to natural origin extract, chemosynthesis or structural modification, biosynthesis or The cultivation of bioconversion, histiocyte, fungal transformation, metabolic pathway etc..Second object of the present invention is to provide this A kind of new application of bright described active salt healthy functions material.
Acarid that the active substance of the present invention is applicable to all kinds and the harm especially dust mite caused, flour mite, compacted shape The sensitive asthmatic etc. that demodicid mite is caused, including the acarid infection to people and animals, people and animals' allergy of acarid induction, asthma, acarid is to food Thing, fabric, room, grain, medical material, crops, ornamental plant gnaw pollution etc..
The active salt healthy functions material of the present invention can be applied as follows:
It is prepared as appointing using active salt healthy functions material of the present invention as having to go out demodicid mite or drive the functional components of demodicid mite effect Meaning regular dosage form, preparation process routinely makes pharmaceutics and cosmetics of everyday use acceptable any conventional dosage form and fabric is fine Dimension, including aerosol, propellant, water aqua type, emulsion-type, putty-type, gelatin, ingot shape, aerosol type, solid Type, capsule, tablet, granule, gel, slow releasing agent, suspending agent, Emulsion, cream, poison powder, poison pen, powder Agent, spray agent, fancy soap, liquid detergent, detergent, shampoo, bath gel, handwashing liquid etc., can be applicable to medicine, guarantor Strong product, healthy product, individual wash the product of protecting (infant washing product), household cleaning product, house pet wash the product of protecting, agriculture and garden Articles for use, or chemically embed or mix and fiber is made anti-demodicid mite press down the markets such as demodicid mite fabric and deposit in the product.The present invention's The preparation method of active salt healthy functions material and preparation way are well known to one of ordinary skill in the art.The present invention Described active substance is safe and reliable, has no side effect, it is adaptable to family, school, office, kindergarten, hospital, guest The acarid that goes out is driven in shop, restaurant, grain depot, Drug Storage, farmland and other places.The active salt healthy functions material of the present invention and Preparation, can be to spray, coat environment or people and animals' external, it is possible to use through other forms.The active salt of the present invention is healthy Functional mass and preparation thereof, can be used alone, it is possible to and the use of other existing combinations of substances, such as drive with other demodicid mite of going out Demodicid mite product mix uses with stiffening effect, to the combination of allergen corrective to reduce the relevant discomfort etc. that anaphylaxis causes.
Principle and feature to the present invention are described below, and example is served only for explaining the present invention, is not intended to limit The scope of the present invention.
Experimental example 1: the present invention is gone out demodicid mite effect
1. experimental technique
1.1 for examination target
Employing standard examination worm: dust mite (Dermatophagoides farinae), female male imago.
1.2 test condition
Incubator temperature is 25 DEG C ± 2 DEG C, and relative humidity is 75% ± 5%
1.3 instruments and material
Anatomical lens, culture dish (diameter 60mm, high 15mm), there is lid ceramic whiteware dish (300mm × 200mm × 50mm), White oil vaseline mixture (1: 1), water-impermeable incubator；
1.4 experimental procedure
Take 4 culture dishs, wherein put into medicament to be measured or with the carrier of chemicals treatment by using method for 3.Another training Foster ware is not put medicament to be measured or puts one block of carrier without chemicals treatment (identical with processing carrier area) as compareing, often Individual culture dish inwall upper limb uniform application white oil vaseline mixture.
200 examination worms are put at each culture dish center, put into acarid feedstuff 0.05g during 30min at culture dish center, it After culture dish is put into water-impermeable incubator.
48h checks and records dead acarid number.
As matched group acarid mortality rate ＞ 20%, test need to re-start.
1.5 results calculate
It is calculated as follows demodicid mite rate of going out, represents with percentage rate (%):
P=R/N × 100
In formula: P-goes out demodicid mite rate；R-death examination borer population；N-test examination borer population；
When matched group acarid mortality rate ＜ 5% is without correction；
2. experimental result (being shown in Table 1)
Table 1 active salt material goes out demodicid mite effect
3. conclusion
According to NY/T 1151.2-2006 " agriculture chemical registration hygienic insecticide indoor pharmacodynamic test method and evaluation second Point: go out demodicid mite and drive demodicid mite agent " be evaluated, this active salt material demodicid mite effect of going out reaches " A " level.
Experimental example 2: the present invention drives demodicid mite effect
1. experimental technique
1.1 for examination target
Employing standard examination worm: dust mite (Dermatophagoides farinae), female male imago.
1.2 test condition
Incubator temperature is 25 DEG C ± 2 DEG C, and relative humidity is 75% ± 5%
1.3 instruments and material
Anatomical lens, culture dish (diameter 60mm, high 15mm), there is lid ceramic whiteware dish (300mm × 200mm × 50mm), White oil vaseline mixture (1: 1), water-impermeable incubator；
1.4 experimental procedure
Taking 7 culture dishs, culture dish centered by 1, remaining 6 culture dish is put around center culture dish and and center Culture dish contacts two-by-two, and contact position adhesive tape clings, and is finally bonded on viscose glue cardboard by 7 culture dishs and makes its position Fixed.
Putting into examination worm in the culture dish of center and be no less than 1000, it is consistent with at the bottom of ware that area is put at 6 culture dish intervals of surrounding Determinand one piece or tester one piece, put acarid feedstuff 0.05g on determinand and tester, experimental provision be placed with lid In porcelain dish, it is finally putting in water-impermeable incubator.
The acarid number on determinand and tester is observed and recorded to 24h anatomical lens.
1.5 results calculate
It is calculated as follows and drives demodicid mite rate, represent with percentage rate (%):
Pc=(1-Nt/No) × 100
In formula: Pc-drives demodicid mite rate；Nt-determinand examination borer population；No-matched group examination borer population；
2. experimental result (being shown in Table 2)
Table 2 active salt material drives demodicid mite effect
3. conclusion
According to NY/T 1151.2-2006 " agriculture chemical registration hygienic insecticide indoor pharmacodynamic test method and evaluation second Point: go out demodicid mite and drive demodicid mite agent " be evaluated, active salt material drives demodicid mite effect and reaches " A " level.
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1: tablet
Take active salt healthy functions material of the present invention, add customary adjuvant, make tablet according to common process.
Sodium artesunate content assaying method
High performance liquid chromatography
Chromatographic condition
It is chromatographic column filler with octadecylsilane key and silica gel, (takes potassium dihydrogen phosphate 1.36 with acetonitrile-phosphate buffer G, the 1000mL that adds water make dissolving, adjust pH value to 3.0 with phosphoric acid) (43: 57) be flowing phase, column temperature 25 DEG C, detection Wavelength is 219nm.
Algoscopy
Take sample appropriate, accurately weighed, it is placed in 50mL volumetric flask, adds methanol appropriate, shaking makes artesunate dissolve, With methanol dilution to scale, shaking up, filter, precision measures subsequent filtrate 20 μ L and injects chromatograph of liquid, records chromatogram, Separately take artesunate reference substance appropriate, accurately weighed, it is placed in 10mL volumetric flask, adds methanol and dissolve and be diluted to scale, It is measured in the same method.According to external standard method with calculated by peak area, to obtain final product.
Embodiment 2: Emulsion
Take active salt healthy functions material of the present invention, add customary adjuvant, make Emulsion according to common process.
Sodium artesunate content assaying method
High performance liquid chromatography
Chromatographic condition
It is chromatographic column filler with octadecylsilane key and silica gel, (takes potassium dihydrogen phosphate 1.36 with acetonitrile-phosphate buffer G, the 1000mL that adds water make dissolving, adjust pH value to 3.0 with phosphoric acid) (43: 57) be flowing phase, column temperature 25 DEG C, detection Wavelength is 219nm.
Algoscopy
Take sample appropriate, accurately weighed, it is placed in 50mL volumetric flask, adds methanol appropriate, shaking makes artesunate dissolve, and uses Methanol dilution, to scale, shakes up, and filters, and precision measures subsequent filtrate 20 μ L and injects chromatograph of liquid, records chromatogram, Separately take artesunate reference substance appropriate, accurately weighed, it is placed in 10mL volumetric flask, adds methanol and dissolve and be diluted to scale, It is measured in the same method.According to external standard method with calculated by peak area, to obtain final product.
Embodiment 3: propellant
Take active salt healthy functions material of the present invention, add customary adjuvant, make propellant according to common process.
Sodium artesunate content assaying method
High performance liquid chromatography
Chromatographic condition
It is chromatographic column filler with octadecylsilane key and silica gel, (takes potassium dihydrogen phosphate 1.36 with acetonitrile-phosphate buffer G, the 1000mL that adds water make dissolving, adjust pH value to 3.0 with phosphoric acid) (43: 57) be flowing phase, column temperature 25 DEG C, detection Wavelength is 219nm.
Algoscopy
Take sample appropriate, accurately weighed, it is placed in 50mL volumetric flask, adds methanol appropriate, shaking makes artesunate dissolve, With methanol dilution to scale, shaking up, filter, precision measures subsequent filtrate 20 μ L and injects chromatograph of liquid, records chromatogram, Separately take artesunate reference substance appropriate, accurately weighed, it is placed in 10mL volumetric flask, adds methanol and dissolve and be diluted to scale, It is measured in the same method.According to external standard method with calculated by peak area, to obtain final product.
Embodiment 4: powder
Take active salt healthy functions material of the present invention, add customary adjuvant, make powder according to common process.
Sodium artesunate content assaying method
High performance liquid chromatography
Chromatographic condition
It is chromatographic column filler with octadecylsilane key and silica gel, (takes potassium dihydrogen phosphate 1.36 with acetonitrile-phosphate buffer G, the 1000mL that adds water make dissolving, adjust pH value to 3.0 with phosphoric acid) (43: 57) be flowing phase, column temperature 25 DEG C, detection Wavelength is 219nm.
Algoscopy
Take sample appropriate, accurately weighed, it is placed in 50mL volumetric flask, adds methanol appropriate, shaking makes artesunate dissolve, With methanol dilution to scale, shaking up, filter, precision measures subsequent filtrate 20 μ L and injects chromatograph of liquid, records chromatogram, Separately take artesunate reference substance appropriate, accurately weighed, it is placed in 10mL volumetric flask, adds methanol and dissolve and be diluted to scale, It is measured in the same method.According to external standard method with calculated by peak area, to obtain final product.
Embodiment 5: abluent
Take active salt healthy functions material of the present invention, add customary adjuvant, make abluent according to common process.
Sodium artesunate content assaying method
High performance liquid chromatography
Chromatographic condition
It is chromatographic column filler with octadecylsilane key and silica gel, (takes potassium dihydrogen phosphate 1.36 with acetonitrile-phosphate buffer G, the 1000mL that adds water make dissolving, adjust pH value to 3.0 with phosphoric acid) (43: 57) be flowing phase, column temperature 25 DEG C, detection Wavelength is 219nm.
Algoscopy
Take sample appropriate, accurately weighed, it is placed in 50mL volumetric flask, adds methanol appropriate, shaking makes artesunate dissolve, With methanol dilution to scale, shaking up, filter, precision measures subsequent filtrate 20 μ L and injects chromatograph of liquid, records chromatogram, Separately take artesunate reference substance appropriate, accurately weighed, it is placed in 10mL volumetric flask, adds methanol and dissolve and be diluted to scale, It is measured in the same method.According to external standard method with calculated by peak area, to obtain final product.
Embodiment 6: soap agent
Take active salt healthy functions material of the present invention, add customary adjuvant, make soap agent according to common process.
Sodium artesunate content assaying method
High performance liquid chromatography
Chromatographic condition
It is chromatographic column filler with octadecylsilane key and silica gel, (takes potassium dihydrogen phosphate 1.36 with acetonitrile-phosphate buffer G, the 1000mL that adds water make dissolving, adjust pH value to 3.0 with phosphoric acid) (43: 57) be flowing phase, column temperature 25 DEG C, detection Wavelength is 219nm.
Algoscopy
Take sample appropriate, accurately weighed, it is placed in 50mL volumetric flask, adds methanol appropriate, shaking makes artesunate dissolve, With methanol dilution to scale, shaking up, filter, precision measures subsequent filtrate 20 μ L and injects chromatograph of liquid, records chromatogram, Separately take artesunate reference substance appropriate, accurately weighed, it is placed in 10mL volumetric flask, adds methanol and dissolve and be diluted to scale, It is measured in the same method.According to external standard method with calculated by peak area, to obtain final product.
Above said content is only the basic explanation under present inventive concept, its object is to make those skilled in the art's energy Enough understand present disclosure and implement according to this, it is impossible to only limiting the scope of the claims of the present invention with the present embodiment, to foundation For the those of ordinary skill of technical solution of the present invention, according to disclosed spirit, the present invention is carried out any Equivalent transformation or modification, all should belong to protection scope of the present invention.

Claims (10)

1. having and go out demodicid mite and drive an active salt healthy functions material for demodicid mite effect, this active salt healthy functions material refers to green grass or young crops Artemisin and derivant thereof and correlative (include but not limited to, arteannuin, dihydroarteannuin, artesunate, Artemether, Arteether, arteannuin C12Derivant, arteannuin C4Derivant, steroid arteannuin, open loop arteannuin, arteannuin structure Simplify thing etc.) exist in a salt form.
2. active salt healthy functions material as claimed in claim 1, can be as a kind of application going out demodicid mite with drive demodicid mite, and it is special Levy be this bulk composition be arteannuin and derivant thereof and correlative (include but not limited to, arteannuin, dihydroarteannuin, Artesunate, Artemether, arteether, arteannuin C12Derivant, arteannuin C4Derivant, steroid arteannuin, open loop Arteannuin, arteannuin structure simplifies thing etc.) exist in a salt form.
3. above-mentioned active salt healthy functions material is the most often prepared as having to go out demodicid mite or drive the functional components of demodicid mite effect Rule dosage form, preparation process routinely makes pharmaceutics and cosmetics of everyday use acceptable any conventional dosage form and fabric fibre.
4. the active salt healthy functions material as described in claims 1 to 3 is arbitrary has the demodicid mite and drive demodicid mite effect of going out, described Preparation includes aerosol, propellant, water aqua type, emulsion-type, putty-type, gelatin, ingot shape, aerosol type, solid Type, capsule, tablet, granule, gel, slow releasing agent, suspending agent, Emulsion, cream, poison powder, poison pen, powder Agent, spray agent, fancy soap, liquid detergent, detergent, shampoo, bath gel, handwashing liquid etc., can be applicable to medicine, guarantor Strong product, healthy product, individual wash the product of protecting (infant washing product), household cleaning product, house pet wash the product of protecting, agriculture and garden Articles for use, or chemically embed or mix and fiber is made anti-demodicid mite press down the markets such as demodicid mite fabric and deposit in the product.It is applicable to house Demodicid mite of going out is driven in front yard, school, office, kindergarten, hospital, hotel, restaurant, grain depot, Drug Storage, farmland and other places Worm.
5. active salt healthy functions material as described in claims 1 to 3, it is characterised in that above-mentioned active salt healthy functions thing Matter can obtain through any approach, include but not limited to natural origin extract, chemosynthesis or structural modification, biosynthesis or The cultivation of bioconversion, histiocyte, fungal transformation, metabolic pathway etc..
6. active salt healthy functions material as described in Claims 1 to 5, it is characterised in that can use well known in the art respectively Planting fibre chemistry mite-proof agent method, technique routinely makes anti-bacteria and mite-proof functional textile.Use finishing method that active salt is healthy Functional mass is attached to the surface of fabric, cannot be only used for the chemical fibres such as terylene, acrylon, viscose glue, it is also possible to for cotton, The anti-demodicid mite of the natural fibre products such as hair processes, or with functional fibre method in fabrication stage of precursor by active salt healthy functions thing Matter adds in fiber, gives fiber acarid prevention and driving functional, can be applicable to anti-demodicid mite and press down demodicid mite fabric product.
7. active salt healthy functions material as described in Claims 1 to 5, it is characterised in that can add well known in the art respectively Planting pharmaceutic adjuvant or food additive, preparation process routinely makes pharmaceutics acceptable any conventional dosage form, it is possible to Make other transmission such as long-acting and slow releasing preparation, controlled release preparation, targeting preparation etc. to be administered systemically preparation.Obtained dosage form can be made Behaviour medicine, veterinary drug, plant medication use or use, and the healthy functions being equally applicable for having prevention and health-care effect produces In product.
8. active salt healthy functions material as described in Claims 1 to 5, it is characterised in that known cosmetics base can be added Matter and auxiliary material and cleaning-nursing product additive, as lived in oil, opaque, colloid, antioxidant, wetting agent, surface Property agent, allergen nertralizer, preservative, pigment, essence, mineral oil, aromatic, nourishing additive agent, astringent, Sunscreen, antibacterial, pruritus, film former, thickening agent etc., make to have and go out demodicid mite and drive the healthy functions of demodicid mite effect Product, can be applicable to cosmetic care articles for use.
9. active salt healthy functions material as described in Claims 1 to 5, it is characterised in that known washing material can be added Such as surfactant, water softener, anti-redeposition agents, allergen nertralizer, bleach, thickening agent, preservative, absorption Agent, enzyme, antibacterial, aerosol propellant etc., make to have and go out demodicid mite and drive the healthy functions product of demodicid mite effect, can apply In washing cleaning supplies.
10. the active salt healthy functions material as described in Claims 1 to 5 is arbitrary has, in preparation, the demodicid mite and driving in demodicid mite product of going out Application.
CN201610565439.8A 2016-07-19 2016-07-19 Development and application of health and functional active salt substance with acarid killing and expelling effects Pending CN105997991A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101116451A (en) * 2007-08-02 2008-02-06 西南大学 Plant miticide derived from artemisia annul l and method for preparing the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101116451A (en) * 2007-08-02 2008-02-06 西南大学 Plant miticide derived from artemisia annul l and method for preparing the same

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