CN105997684A

CN105997684A - Traditional Chinese medicine lotion for promoting hair growth and preparation method thereof

Info

Publication number: CN105997684A
Application number: CN201610491225.0A
Authority: CN
Inventors: 赵东海; 齐玲; 赵贵芳; 代晓微; 王舒然
Original assignee: Jilin Medical College
Current assignee: Jilin Medical College
Priority date: 2016-06-29
Filing date: 2016-06-29
Publication date: 2016-10-12

Abstract

The invention discloses traditional Chinese medicine lotion for promoting hair growth. The lotion is prepared from the following components in percentage by mass: 20-30 percent of a traditional Chinese medicine alcohol extract, 5-8 percent of sodium lauryl ether sulfate, 3-5 percent of cocamidopropyl betaine, 3-5 percent of hydroxypropyl methyl cellulose, 0.3-0.5 percent of avocado oil, 0.5-1 percent of jojoba oil, 0.1-0.3 percent of ethylenediamine tetraacetic acid disodium, 0.5-1 percent of myristic acid, 0.5-1 percent of hydrolyzed wheat protein, 0.1-0.2 percent of methylisothiazolinone, 0.1-0.3 percent of menthol, 0.1-0.3 percent of preservative, 0.5-1 percent of essence, 0.5-1 percent of L-cystine, 0.1-0.3 percent of zinc gluconate and the balance of deionized water. The compound traditional Chinese medicine composition is reasonable and scientific in formula, has high safety, can be used for stimulating hair growth, effectively promoting hair growth and preventing alopecia and recurrent dandruff, and is good in application effect. The invention further discloses a method for preparing the traditional Chinese medicine lotion for promoting hair growth. The method is simple in steps, does not have special requirement for equipment, has strong operability, and is suitable for industrial production.

Description

A kind of growth-promoting sends out Chinese medicine lotion and preparation method thereof

Technical field

The present invention relates to a kind of shampoo, especially relate to a kind of growth-promoting and send out Chinese medicine lotion and preparation method thereof.

Background technology

With the quickening pace of modern life, the increasing of operating pressure, increasing artificial alopecia and worried.Alopecia broad categories, type are more, and situation is different, common are alopecia areata, male pattern alopecia, seborrheic alopecia three kinds.The limitation plaque-like alopecia of alopecia areata system, its feature is that lesion scalp is normal, NIP, no conscious sympton, Chang Yu stumbles on, head has circle or oval alopecia spot, the hair of alopecia area edge is more loose, is drawn out easily very much, and the course of disease sustainable several months of alopecia areata is to the several years, big multipotency spontaneous recovery, but also have recurrent exerbation；It is between twenty and fifty that male pattern alopecia is apt to occur in male, and is more common in brain worker, and hair is dried shortage gloss；Seborrheic alopecia, is also more common in male adults, and scalp is the most greasy shinny or has a large amount of dandruff, in canescence pityrosporum shape, conscious scratching where it itches, time permanent forehead both sides and head hair start symmetry and come off, sparse attenuating, affected part, due to hair follicle atrophy, frequently results in permanent alopecia.

Owing to hair plays an important role in the appearance of people, being also the index of person health status, therefore hair growth promoter is subject to concern and the attention of more and more consumers simultaneously.Current hair growth promoter can be divided into chemistry hair growth promoter and Chinese herbal medicine hair growth promoter, the safety of chemistry hair growth promoter to be worth discussion, and its effect is single, and Chinese herbal medicine hair growth promoter is of a great variety, and effect differs, in addition it is also necessary to the medicinal herb components that screening is suitable for.

Such as, publication number CN1939256A, the Chinese patent in publication date on April 4th, 2007 discloses a kind of removing scurf and relieving itching, the draft shampoo of hair care anticreep, it is the shampoo that the medicine by following weight ratio and method prepare: Herba Agrimoniae 20 ~ 40 grams, Herba Ecliptae 20 ~ 40 grams, Rhizoma Chuanxiong 10 ~ 20 grams, Cortex Dictamni 10 ~ 20 grams, the Fructus Kochiae 20 ~ 40 grams, Pericarpium Granati 10 ~ 10 grams, press draft extracting solution 10 ~ 20% again, alkyl-glucoside 10 ~ 20%, bioactive peptide modulator 1 ~ 2%, tea saponin 1 ~ 5%, silk peptide 1 ~ 5%, Aloe extraction solution 1 ~ 5%, silicone oil 4 ~ 6%, polyquaternary ammonium salt 2 ~ 5%, essence 0.3 ~ 0.5%, Kazon 0.1%, pure water 31.4 ~ 56.6%.This draft shampoo only reaches to promote the effect of hair growth promoting from the angle of the traditional Chinese medical science to improve microcirculation, there is no other effects, now studies have found that, alopecia also metabolic function and nourishment with cell has important relationship, therefore the effect of this draft shampoo inconspicuous, additionally the active component in this draft shampoo is difficult to infiltration and suffers from institute, affects using effect.

Summary of the invention

The present invention is to solve the above-mentioned technical problem existing for the shampoo of prior art, it is provided that a kind of reasonable science of formula, and safety is good, effectively facilitates hair growth anti-alopecia-stopping and dandruff regeneration, and the growth-promoting that using effect is good sends out Chinese medicine lotion.

Present invention also offers a kind of growth-promoting and send out Chinese medicine lotion preparation method, processing step is simple, workable, to equipment without particular/special requirement, is suitable for industrialized production.

To achieve these goals, the present invention is by the following technical solutions:

A kind of growth-promoting of the present invention sends out Chinese medicine lotion, it is made up of the component of following mass percent: Chinese medicine ethanol extract 20 ~ 30%, sodium lauryl tri(oxyethyl) sulfate 5 ~ 8%, cocamido propyl betaine 3 ~ 5%, hydroxypropyl methyl cellulose 3 ~ 5%, American Avocado Tree oil 0.3 ~ 0.5%, Jojoba oil 0.5 ~ 1%, disodiumedetate 0.1 ~ 0.3%, myristic acid 0.5 ~ 1%, hydrolyzed wheat protein 0.5 ~ 1%, Methylisothiazolinone 0.1 ~ 0.2%, menthol 0.1 ~ 0.3%, preservative 0.1 ~ 0.3%, essence 0.5 ~ 1%, CYSTINE 0.5 ~ 1%, zinc gluconate 0.1 ~ 0.3%, surplus is deionized water.The invention provides a kind of growth-promoting and send out lotion, wherein hydrolyzed wheat protein can help to promote the protein expression that those are relevant to hair new life, finally it is divided into various full-time cell and supports natural on-off cycles of hair growth and renewal, Synergistic between Chinese medicine ethanol extract, hydrolyzed wheat protein, CYSTINE and zinc gluconate several effect component, energy enriched nutritive, strengthen cellular metabolism function, improve blood microcirculation, make telangiectasis, thus play and stimulate hair growth promoting and promote the effect of human hair growth, and effective anti-alopecia-stopping and dandruff regenerate；American Avocado Tree oil has stronger osmosis, permeable layer, can strengthen curative effect, can repair damaged skin, beneficially hair regrowth simultaneously；Jojoba oil moistens and moistening effect is the best, can increase moisture of skin, also can soft hair and massaging scalp, natural on-off cycles of hair growth and hair care can be helped；Menthol has the effects such as antipruritic, refrigerant, antiinflammatory, also has permeation enhancers effect, can promote that effective ingredient enters skin, improve using effect；Hydroxypropyl methyl cellulose plays the effect of stabilizer suspending agent, makes each component in the present invention keep homogeneous, stable.The present invention is optimized improvement to whole basic components, the reasonable science of formula, each material performance is gentleer, the stability of whole system is good with safety, each component coordinated, has good foaming and wet performance, energy balance skin pH, and easily clean, hair growth promoting can be stimulated, effectively facilitate hair growth anti-alopecia-stopping and dandruff regeneration.

As preferably, described Chinese medicine ethanol extract prepares by the following method: by 40 ~ 50 portions of Rhizoma Zingiberis Recenss, 20 ~ 30 parts of drynaria baroniis, 10 ~ 20 portions of Fructus Zanthoxylis, 3 ~ 5 portions of Herba Ecliptaes, 1 ~ 3 part of Bombyx mori L., 5 ~ 10 portions of Aloes, 15 ~ 20 parts of Folium Mori, 10 ~ 15 parts of Fructus Vaccinii Bracteati, 15 ~ 20 portions of Cacumen Platycladis, 40 ~ 50 parts of Flos Carthamis, 10 ~ 15 parts of Fructus Psoraleaes, 5 ~ 10 parts of SUIGUBU, 5 ~ 10 parts of Radix Angelicae Sinensis, 15 ~ 20 parts of Radixs Astragali, after the weight portion of 5 ~ 10 portions of Radix Glycyrrhizaes weighs each raw material, it is incorporated as 65% ethanol water of raw material gross mass 20 ~ 30 times, after soaking at least one week, filters, sterilizing, obtains Chinese medicine ethanol extract.In the Chinese medicine ethanol extract side of the present invention, Radix Angelicae Sinensis, Flos Carthami energy nourshing blood and promoting blood circulation, stimulate the menstrual flow row arteries and veins；Cacumen Platycladi, Folium Mori can expelling wind and clearing away heat dehumidifying, anti-inflammations；Fructus Vaccinii Bracteati, Rhizoma Zingiberis Recens, drynaria baronii, Fructus Zanthoxyli and Bombyx mori L. play that supporing yang temperature is logical, expelling wind and removing dampness altogether, expelling wind and removing dampness, promoting blood circulation to restore menstrual flow loosing the interspaces of skin and muscles, growth-promoting deed as tiny as hair；Fructus Psoraleae, SUIGUBU can blood circulation promoting and blood stasis dispelling, promote local blood follow, nutrition hair；The Radix Astragali can tonifying Qi and lifting yang, benefiting QI for strengthening the superficies；Aloe can promote scalp blood circulation and metabolism, supplements the nutrients for hair papilla, and promotes the scalp rehabilitation having damage thoughts dye, and the oils and fats of minimizing oily hair overflows, and promotes that new sending out regenerates；Radix Glycyrrhizae then plays coordinating the actions of various ingredients in a prescription effect.Chinese medicine ethanol extract safety of the present invention is good, and each component coordinated brings out the best in each other, has warm, fills blood, the meridian dredging, and blood circulation promoting excites pore to expand, and promotes the specially good effect of hair growth.

As preferably, soak after each raw material pulverizing.

As preferably, during immersion, stirred once every 2 ~ 3 days.

A kind of growth-promoting sends out the preparation method of Chinese medicine lotion, concretely comprise the following steps: after weighing each component by proportioning, deionized water is heated to 40 ~ 50 DEG C, add sodium lauryl tri(oxyethyl) sulfate, cocamido propyl betaine, hydroxypropyl methyl cellulose and disodiumedetate, stir, be subsequently added into American Avocado Tree oil, Jojoba oil, Methylisothiazolinone and menthol, room temperature it is cooled to after stirring, add remaining ingredient, stir, obtain growth-promoting and send out Chinese medicine lotion.In the preparation method of the present invention, emphasis one is: by controlling the order of addition of each raw material, thus to ensure mixing uniformity and the stability of each component；Emphasis two is: ensureing on the premise of each component dissolubility, controls to add temperature less than 50 DEG C, in order to avoid affecting effect of active component, even causes product variable color, spoiled.

Therefore, there is advantages that

(1) whole basic components is optimized improvement, the reasonable science of formula, each material performance is gentleer, the stability of whole system is good with safety, each component coordinated, has good foaming and wet performance, energy balance skin pH, and easily clean, hair growth promoting can be stimulated, effectively facilitate hair growth anti-alopecia-stopping and dandruff regeneration；

(2) processing step is simple, workable, to equipment without particular/special requirement, is suitable for industrialized production, by controlling order of addition and the charge temperature of each raw material, it is ensured that the mixing uniformity of each component and stability, it is to avoid affect effect of active component.

Detailed description of the invention

Below by detailed description of the invention, the present invention will be further described.

In the present invention, if not refering in particular to, all percentage ratios are unit of weight, all devices and raw material and are all commercially available or the industry is conventional, the method in following embodiment, if no special instructions, are this area conventional method.

Embodiment 1

(1) 40kg Rhizoma Zingiberis Recens, 20kg drynaria baronii, 10kg Fructus Zanthoxyli, 3kg Herba Ecliptae are pressed, 1kg Bombyx mori L., 5kg Aloe, 15kg Folium Mori, 10kg Fructus Vaccinii Bracteati, 15kg Cacumen Platycladi, 40kg Flos Carthami, 10kg Fructus Psoraleae, 5kg SUIGUBU, 5kg Radix Angelicae Sinensis, the 15kg Radix Astragali, after the weight proportion of 5kg Radix Glycyrrhizae weighs each raw material, 65% ethanol water of raw material gross mass 20 times will be incorporated as after each raw material pulverizing, soaked at least one week, during immersion every stirring in 2 days once, filter, sterilizing, obtains Chinese medicine ethanol extract, stand-by；

null(2) Chinese medicine ethanol extract 20% is pressed，Sodium lauryl tri(oxyethyl) sulfate 5%，Cocamido propyl betaine 3%，Hydroxypropyl methyl cellulose 3%，American Avocado Tree oil 0.3%，Jojoba oil 0.5%，Disodiumedetate 0.1%，Myristic acid 0.5%，Hydrolyzed wheat protein 0.5%，Methylisothiazolinone 0.1%，Menthol 0.1%，Preservative 0.1%，Essence 0.5%，CYSTINE 0.5%，Zinc gluconate 0.1%，Surplus is that the mass percent of deionized water measures each component，Deionized water is heated to 40 DEG C，Add sodium lauryl tri(oxyethyl) sulfate、Cocamido propyl betaine、Hydroxypropyl methyl cellulose and disodiumedetate，Stir，It is subsequently added into American Avocado Tree oil、Jojoba oil、Methylisothiazolinone and menthol，Room temperature it is cooled to after stirring，Add remaining ingredient，Stir，Obtain growth-promoting and send out Chinese medicine lotion.

Embodiment 2

(1) 50kg Rhizoma Zingiberis Recens, 30kg drynaria baronii, 20kg Fructus Zanthoxyli, 5kg Herba Ecliptae are pressed, 3kg Bombyx mori L., 10kg Aloe, 20kg Folium Mori, 15kg Fructus Vaccinii Bracteati, 20kg Cacumen Platycladi, 50kg Flos Carthami, 15kg Fructus Psoraleae, 10kg SUIGUBU, 10kg Radix Angelicae Sinensis, the 20kg Radix Astragali, after the weight proportion of 10kg Radix Glycyrrhizae weighs each raw material, 65% ethanol water of raw material gross mass 30 times will be incorporated as after each raw material pulverizing, soaked at least one week, during immersion every stirring in 3 days once, filter, sterilizing, obtains Chinese medicine ethanol extract, stand-by；

null(2) Chinese medicine ethanol extract 30% is pressed，Sodium lauryl tri(oxyethyl) sulfate 8%，Cocamido propyl betaine 5%，Hydroxypropyl methyl cellulose 5%，American Avocado Tree oil 0.5%，Jojoba oil 1%，Disodiumedetate 0.3%，Myristic acid 1%，Hydrolyzed wheat protein 1%，Methylisothiazolinone 0.2%，Menthol 0.3%，Preservative 0.3%，Essence 1%，CYSTINE 1%，Zinc gluconate 0.3%，Surplus is that the mass percent of deionized water measures each component，Deionized water is heated to 50 DEG C，Add sodium lauryl tri(oxyethyl) sulfate、Cocamido propyl betaine、Hydroxypropyl methyl cellulose and disodiumedetate，Stir，It is subsequently added into American Avocado Tree oil、Jojoba oil、Methylisothiazolinone and menthol，Room temperature it is cooled to after stirring，Add remaining ingredient，Stir，Obtain growth-promoting and send out Chinese medicine lotion.

Embodiment 3

(1) 48kg Rhizoma Zingiberis Recens, 25kg drynaria baronii, 15kg Fructus Zanthoxyli, 4kg Herba Ecliptae are pressed, 2kg Bombyx mori L., 7kg Aloe, 18kg Folium Mori, 12kg Fructus Vaccinii Bracteati, 18kg Cacumen Platycladi, 45kg Flos Carthami, 12kg Fructus Psoraleae, 7kg SUIGUBU, 8kg Radix Angelicae Sinensis, the 18kg Radix Astragali, after the weight proportion of 8kg Radix Glycyrrhizae weighs each raw material, 65% ethanol water of raw material gross mass 25 times will be incorporated as after each raw material pulverizing, soaked at least one week, during immersion every stirring in 3 days once, filter, sterilizing, obtains Chinese medicine ethanol extract, stand-by；

null(2) Chinese medicine ethanol extract 25% is pressed，Sodium lauryl tri(oxyethyl) sulfate 6%，Cocamido propyl betaine 4%，Hydroxypropyl methyl cellulose 4%，American Avocado Tree oil 0.4%，Jojoba oil 0.7%，Disodiumedetate 0.2%，Myristic acid 0.7%，Hydrolyzed wheat protein 0.8%，Methylisothiazolinone 0.15%，Menthol 0.2%，Preservative 0.2%，Essence 0.7%，CYSTINE 0.7%，Zinc gluconate 0.2%，Surplus is that the mass percent of deionized water measures each component，Deionized water is heated to 45 DEG C，Add sodium lauryl tri(oxyethyl) sulfate、Cocamido propyl betaine、Hydroxypropyl methyl cellulose and disodiumedetate，Stir，It is subsequently added into American Avocado Tree oil、Jojoba oil、Methylisothiazolinone and menthol，Room temperature it is cooled to after stirring，Add remaining ingredient，Stir，Obtain growth-promoting and send out Chinese medicine lotion.

The effect of the present invention is described below by concrete clinical case:

(1) sufferer: choose 124 example sufferers, alopecia areata 68 example, male 56 examples, female 12 example, 16 ~ 58 years old age, the course of disease 2 months ~ 4 years altogether；Wherein alopecia areata person 38 example at 1, alopecia areata person 18 example at 2, > alopecia areata person 12 example at 3；Seborrheic alopecia 56 example, male 38 examples, women 18 example, 20 ~ 65 years old age, the course of disease 6 months ~ 3 years.First 2 months unused hair growth promoting class medicines excessively and sugar cortical hormone.

(2) using method: after cleaning hair with clear water, takes the growth-promoting of the present invention and sends out Chinese medicine lotion 10 ~ 20ml and be coated with and put on the skin at the hairline cleaned by clear water, rub scalp 10 min the most equably, again by clean water, within every two days, clean once, within 4 weeks, be 1 course for the treatment of, use 2 courses for the treatment of.

(3) efficacy determination: formulate criterion of therapeutical effect with reference to " guideline of clinical investigations of new Chinese medicine treatment alopecia ".1. alopecia areata criterion of therapeutical effect, recovery from illness: hair stops coming off, newly send out well-grown whole；Effective: hair stops coming off, new sending out regenerates > 70%；Effective: hair stops coming off, and firewood occurs long 30 ~ 70%；Invalid: kainogenesis length < 30% or continue to de-originator.2. seborrheic alopecia criterion of therapeutical effect, recovery from illness: hair stops coming off, substantially without greasy feeling, without pruritus, without desquamation, > have Xin Fa or fine hair on birds or animals hair at 80% skin lesion；Effective: to have kainogenesis long at 60% skin lesion, greasy feeling and lipid desquamation significantly reduce, and pruritus substantially alleviates；Effective: to have kainogenesis long at 30% skin lesion, greasy feeling and lipid desquamation have part to reduce, and pruritus has and alleviates；Invalid: long without kainogenesis, greasy feeling and lipid desquamation are without reducing, and pruritus is without alleviating.

(4) result is used:

Alopecia areata (totally 68 example): 10 examples of fully recovering, effective 44 examples, effective 10 examples, invalid 4 examples, total effective rate 94.1%；

Alopecia seborrheica (56 example): 4 examples of fully recovering, effective 42 examples, effective 4 examples, invalid 6 examples, total effective rate 89.3%.

The present invention 124 example through clinical usage, does not finds that obvious adverse reaction, total effective rate reach 91.9%, illustrates that the present invention promotes that hair growth is the most obvious.

Embodiment described above is the one preferably scheme of the present invention, and the present invention not makees any pro forma restriction, also has other variant and remodeling on the premise of without departing from the technical scheme described in claim.

Claims

1. a growth-promoting sends out Chinese medicine lotion, it is characterized in that, it is made up of the component of following mass percent: Chinese medicine ethanol extract 20 ~ 30%, sodium lauryl tri(oxyethyl) sulfate 5 ~ 8%, cocamido propyl betaine 3 ~ 5%, hydroxypropyl methyl cellulose 3 ~ 5%, American Avocado Tree oil 0.3 ~ 0.5%, Jojoba oil 0.5 ~ 1%, disodiumedetate 0.1 ~ 0.3%, myristic acid 0.5 ~ 1%, hydrolyzed wheat protein 0.5 ~ 1%, Methylisothiazolinone 0.1 ~ 0.2%, menthol 0.1 ~ 0.3%, preservative 0.1 ~ 0.3%, essence 0.5 ~ 1%, CYSTINE 0.5 ~ 1%, zinc gluconate 0.1 ~ 0.3%, surplus is deionized water.

A kind of growth-promoting the most according to claim 1 sends out Chinese medicine lotion, it is characterized in that, described Chinese medicine ethanol extract prepares by the following method: by 40 ~ 50 portions of Rhizoma Zingiberis Recenss, 20 ~ 30 parts of drynaria baroniis, 10 ~ 20 portions of Fructus Zanthoxylis, 3 ~ 5 portions of Herba Ecliptaes, 1 ~ 3 part of Bombyx mori L., 5 ~ 10 portions of Aloes, 15 ~ 20 parts of Folium Mori, 10 ~ 15 parts of Fructus Vaccinii Bracteati, 15 ~ 20 portions of Cacumen Platycladis, 40 ~ 50 parts of Flos Carthamis, 10 ~ 15 parts of Fructus Psoraleaes, 5 ~ 10 parts of SUIGUBU, 5 ~ 10 parts of Radix Angelicae Sinensis, 15 ~ 20 parts of Radixs Astragali, after the weight portion of 5 ~ 10 portions of Radix Glycyrrhizaes weighs each raw material, it is incorporated as 65% ethanol water of raw material gross mass 20 ~ 30 times, after soaking at least one week, filter, sterilizing, obtain Chinese medicine ethanol extract.

A kind of growth-promoting the most according to claim 2 sends out Chinese medicine lotion, it is characterised in that soak after each raw material pulverizing.

4. send out Chinese medicine lotion according to a kind of growth-promoting described in Claims 2 or 3, it is characterised in that during immersion, every stirring in 2 ~ 3 days once.

5. a growth-promoting as claimed in claim 1 sends out the preparation method of Chinese medicine lotion, it is characterized in that, concretely comprise the following steps: after weighing each component by proportioning, deionized water is heated to 40 ~ 50 DEG C, add sodium lauryl tri(oxyethyl) sulfate, cocamido propyl betaine, hydroxypropyl methyl cellulose and disodiumedetate, stir, it is subsequently added into American Avocado Tree oil, Jojoba oil, Methylisothiazolinone and menthol, room temperature it is cooled to after stirring, add remaining ingredient, stir, obtain growth-promoting and send out Chinese medicine lotion.