CN105997243A - Application of three-dimensional vascular patch molding technology based on individualized hemodynamics optimization - Google Patents
Application of three-dimensional vascular patch molding technology based on individualized hemodynamics optimization Download PDFInfo
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- CN105997243A CN105997243A CN201610280579.0A CN201610280579A CN105997243A CN 105997243 A CN105997243 A CN 105997243A CN 201610280579 A CN201610280579 A CN 201610280579A CN 105997243 A CN105997243 A CN 105997243A
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Abstract
The invention relates to a three-dimensional vascular patch molding technology based on individualized hemodynamics optimization and a preparation method for same. The preparation method comprises the steps that (1) data is collected, and a three-dimensional digital model is acquired; (2) individualized virtual operation researches are analyzed, and patch design is determined; (3) a patch molding die is fabricated by a 3D printing technology; and (4) the patch to be molded is placed on a raised face of the die and then buckled with a concave face of the die, a stationary liquid is poured into the die, horizontal placement is conducted for fixation and molding, the die is removed after the molding, and finally the three-dimensional patch is obtained. The method has the advantages that the patch provided by the invention is three-dimensional, can be individualized and satisfies requirements of hemodynamics.
Description
Technical field
The present invention relates to medical material technical field, specifically, be the three of the optimization of individuation hemodynamics
The application of the three-dimensional vascular patch forming technique of dimension.
Background technology
Congenital heart disease and sticking patch application: the most up-to-date medical information shows, congenital heart disease is (hereinafter referred to as
" congenital heart disease ") it is the commonly encountered diseases in infant, frequently-occurring disease.In China, congenital heart disease sickness rate accounts for the baby that is born
The 8 ‰～12 ‰ of youngster, it has also become the primary cause of disease of neonatal death.According to statistics, China there are about 150,000 every year
The newly-increased congenital heart disease patient of left and right, wherein arteries of complex congenital heart defect patient accounts for 30～40%.Along with medical science and technology
Progressive, many infant, the congenital heart disease of non-neonate include that Complex Congenital Heart Diseases the most can obtain
Radical cure, domestic 3～40,000 infants that there are about every year accept congenital heart disease operative treatment.Wherein, some of complex congenital heart disease
Hypotype is narrow or block due to blood vessel and efferent tract, need Vein graft sticking patch expand narrow blood vessel or
Person's efferent tract carries out surgical intervention.In conventional clinical position, vascular patch implantation position, shape, big
The selecting the Main Basis operator clinical experience to judge and determine of little and angle.Objective, accurate owing to lacking
True determination methods, postoperative it may happen that sticking patch distortion, deformation, angulation, cause the generation that remnants block.
And these can be designed by the optimum hemodynamic individuation vascular patch of computer aided animation and
3D print die processing pericardium sticking patch forming technique is solved.I.e. according to the growth of blood vessel before operation in patients
Condition carries out hemodynamics computer simulation, determines the hemodynamics optimal design of individuation vascular patch
Scheme, and carry out individuation 3D print die according to this scheme, finally realize pericardium sticking patch forming technique.
Calculate hemodynamics: in recent years, along with the development of computer technology, with numerical simulation as base
Plinth, the calculating hemodynamics (Computational grown up in conjunction with flowing three-dimensional visualization technique
Hemodynamics) be quantitative analysis hemodynamic parameter change, in vitro study blood flow movement track and
Objective quantitative assessment, design sticking patch scheme provide possibility.Calculate hemodynamics and utilize clinical medicine image
Data, such as ultrasonic (Ultrasound, US), nuclear magnetic resonance, NMR (Magnetic Resonance, MRI), electrometer
Calculation machine x-ray tomography (Computed Tomography, CT) image, by blood vessel morphology,
The multi-aspect information such as hemodynamics, cardiac function is accurately measured, and dissects according to patient self and physiology is special
Point, the physiologic information (such as fluctuation pressure, blood flow) suffering from individuation by solving imparting is boundary condition
Blood flow governing equation carrys out the blood mobility status of the true internal milieu of analog approximation, and then can assess patient's sticking patch
The change of outflow tract of right ventricle Hydrodynamic character before and after implantation, more intuitively studies the implantation of sticking patch for doctor
The selection of position, shape, size and angle, and the factor such as patching material characteristic is on hemodynamic impact
Important means are provided.
Retrieving patent documentation, technical paper etc., the three-dimensional optimized about individuation hemodynamics is stood
The application of body vascular patch forming technique yet there are no report.
Summary of the invention
It is an object of the invention to for deficiency of the prior art, it is provided that a kind of individuation hemodynamics optimizes
The preparation method of 3 D stereo sticking patch.
Another purpose of the present invention is to provide the 3 D stereo sticking patch that a kind of individuation hemodynamics optimizes.
For achieving the above object, the present invention adopts the technical scheme that: a kind of individuation hemodynamics optimizes
3 D stereo sticking patch, described preparation method comprises the following steps: (1) gather data acquisition 3-dimensional digital
Changing model, (2) are analyzed individuation virtual operation and are determined sticking patch design, and (3) utilize 3D printing technique
Making sticking patch mould, sticking patch to be formed is positioned on mould convex surface by (4), then with mould curved surface
Fasten, in it, irrigate fixative, horizontal positioned molding to be fixed, remove mould after molding, i.e. obtain
Obtain 3 D stereo sticking patch.
Described step (1) is by obtaining the clinical MRI image data before operation in patients and supersonic blood
Metrical information, completes to treat that operated vessels area three-dimensional digital model is rebuild.
Described step (2) is implanted for utilizing cad technique to implement virtual sticking patch, sets with different virtual operations
Meter scheme threedimensional model is Research foundation, carries out hemodynamics qualitative assessment and visualization display respectively, complete
Become the analysis of result of calculation, the hemodynamics feature under different operation plans is compared.
Described step (2) is implanted for utilizing cad technique to implement virtual sticking patch, sets with different virtual operations
Meter scheme threedimensional model is Research foundation, carries out hemodynamics qualitative assessment and visualization display respectively, complete
Become the analysis of result of calculation, the hemodynamics feature under different operation plans is compared；Utilize and calculate
Hydrodynamic method, establishes blood flow movement computation model after accurate simulation vascular patch is implanted, to Three-dimensional Gravity
Build sticking patch implanted region vascular pattern and carry out hemodynamics simulation and analysis；Use based on limited control volume
The computational fluid dynamics of rule carries out Simulation of Blood；Realize pulsatile blood flow three-dimensional flow field by computer to consider
Hemodynamics accurate simulation under Repiration, vascular resistance, blood vessel elasticity physiological condition, and will calculate
Result carries out visualization processing and compares, to every kind of model sticking patch implantation position, shape, size and angle feelings
Condition carries out overall merit, finds individual's optimal hemodynamics operation embodiment.
Described step (4), for be positioned on mould convex surface by pericardium, then fastens with mould curved surface,
In it, irrigate the fixing glutaraldehyde solution used of pericardium sticking patch, horizontal positioned molding to be fixed, go after molding
Except mould obtains molded pericardium sticking patch, i.e. 3 D stereo sticking patch.
For realizing above-mentioned second purpose, the present invention adopts the technical scheme that: a kind of individuation hemodynamic
Learning the 3 D stereo sticking patch optimized, described 3 D stereo sticking patch prepares by the following method: (1) gathers number
According to obtaining three-dimensional digitalization model, (2) are analyzed individuation virtual operation and are determined sticking patch design, (3) profit
Making sticking patch mould with 3D printing technique, sticking patch to be formed is positioned on mould convex surface by (4),
Then fastening with mould curved surface, irrigate fixative in it, horizontal positioned molding to be fixed, after molding
Remove mould, i.e. obtain 3 D stereo sticking patch.
Described 3 D stereo sticking patch is applied in congenital heart disease operation.
The invention has the advantages that:
1, the sticking patch of the present invention is 3 D stereo, relative to two dimensional surface sticking patch, more agrees with patient's
Vascular morphology.
2, the sticking patch of the present invention can carry out individuation customization according to different patients.
3, the sticking patch of the present invention is through hemodynamics matching, more conforms to hemodynamic requirement.
Accompanying drawing explanation
Accompanying drawing 1 is 3 D stereo sticking patch and the structural representation of mould of the present invention.
Accompanying drawing 2 is 3 D stereo sticking patch and the structural representation of mould of the present invention.
Accompanying drawing 3 is the photo of the mould of the 3 D stereo sticking patch of the present invention.
Accompanying drawing 4 is the application process of the 3 D stereo sticking patch mould of the present invention.
Detailed description of the invention
The detailed description of the invention provided the present invention below in conjunction with the accompanying drawings elaborates.
The reference and the ingredient that relate in accompanying drawing are as follows:
1, mould curved surface
2, sticking patch to be formed
3, mould convex surface
Embodiment 1
(1) data acquisition three-dimensional digitalization model is gathered
By the clinical MRI image data before acquisition operation in patients, and supersonic blood metrical information, complete
Treat that operated vessels area three-dimensional digital model is rebuild.A series of two dimension DICOM is obtained by MRI scan
View data is in order to the follow-up three-dimensional reconstruction carrying out anatomical structure.Obtained in each tube chamber by cardiac ultrasonic scanning
Time dependent blood flowing speed information.The view data of DICOM format is imported highly integrated medical science
Image processing softwareIn, MRI scan the view data produced is carried out pre-
Process, choose, by screening, the image that sticking patch implanted region is intact, rebuild 3-dimensional digital pulmonary artery image.
(2) analyze individuation virtual operation and determine sticking patch design
Utilize patient medical image data to carry out individuation three-dimensional reconstruction, and combine patient self anatomical features and set
Count multiple feasible sticking patch and implant scheme, such as different implantation positions, shape, size and angle.Utilize CAD
The virtual sticking patch of technology implementation is implanted, with different virtual operation design threedimensional models as Research foundation, respectively
Carry out hemodynamics qualitative assessment and visualization display, complete the analysis of result of calculation, to difference operation side
Hemodynamics feature under case compares.Utilize computational fluid dynamics method, establish accurate simulation blood
Blood flow movement computation model after tubular patch implantation, carries out blood flow to three-dimensional reconstruction sticking patch implanted region vascular pattern
Kinetic simulation fits analysis.Use based on finite volume scheme Computational Fluid Dynamic Analysis software then
Ansys-Fluent 14.0 carries out Simulation of Blood.By C-language Programming Design programming User-Defined Functions (UDF)
Carry out calculating control, it is achieved pulsatile blood flow three-dimensional flow field considers Repiration, vascular resistance, blood vessel elasticity etc.
Hemodynamics accurate simulation under physiological condition, and result of calculation is carried out visualization processing and compares, right
The situations such as every kind of model sticking patch implantation position, shape, size and angle carry out overall merit, find patient
Bodyization optimal hemodynamics operation embodiment.
(3) utilize 3D printing technique to make sticking patch mould, explore individual's sticking patch fixing means
In conjunction with 3D printing technique, make and become through virtual operation design individual's optimal sticking patch design
Mould, inquires into operation technique feasibility and operating feature with clinical operation doctor, jointly in conjunction with hemodynamic
Learn analysis result, determine that individual meets the optimum operation implantation scheme of optimal hemodynamics condition.
Utilize the glutaraldehyde fixing means to sticking patch based on clinic, printed sticking patch mould in conjunction with 3D, visited
Rope Digital Design meets the individuation sticking patch forming technique of patient vessel's physiological property, carries out and follows up a case by regular visits to face with postoperative
Bed data acquisition, complication issuable to postoperative patient is predicted, and for relevant medical, personnel provide ginseng
Examine.
Embodiment 2
Choose an example and need to carry out the children with CHD of sticking patch transplanting, operation process needs apply Vein graft to mend
Sheet expands narrow outflow tract of right ventricle and pulmonary artery (including branch), thus releases outflow obstruction, reaches
The purpose of surgical radical treatment.
Gather the preoperative image data of infant, obtained by MRI and cardiac ultrasonic method and carry out calculating blood flow
In 3 D anatomy structure information needed for mechanical analysis and Diverging area, the data such as blood flow rate are as calculating number
The model construction basis of value simulation and boundary condition basis of design, complete infant individuation sticking patch implanted region solution
Cut open the three-dimensional reconstruction of structure, simulated and virtual operation by infant individuation hemodynamics, be determined for compliance with this
The optimal hemodynamic sticking patch of infant designs.Utilize 3D printing technique, make infant individuation sticking patch and become
Type physical entity mould, strict sterilization, fixed-type for Vein graft sticking patch in art.
Operation takes infant Vein graft (A), is positioned on individuation sticking patch mould convex surface (B), then
Fasten with mould curved surface part, in it, irrigate the fixing glutaraldehyde solution used of pericardium sticking patch, level
Place molding to be fixed (C), after 15 minutes remove mould, it is thus achieved that molded pericardium sticking patch, its shape with
Angle is preferable (D), the patch model of matching Individual Digital design dramatically, can in operation very well
Ground helps patient easily to position implant site, shape and angle.The more important thing is, this meet blood flow
The body vessel of mechanics individuation 3 D stereo sticking patch is repaired and graft application, can preferably help patient to enter
Row post-operative recovery, reduces complication.
This research, on the basis of vascular patch clinical treatment molding, fixing conventional method, utilizes and calculates fluid
Kinetics and 3D printing technique make individual's sticking patch mould, it is achieved individual's treatment with
Optimum hemodynamics design so that the improvement of operation technique have something to base on, beneficially modus operandi is with clinical
Establishment of standard.Additionally, sticking patch molding in this research, technique for fixing are easily operated, beneficially clinical expansion
With universal.
The above is only the preferred embodiment of the present invention, it is noted that common for the art
Technical staff, on the premise of without departing from the inventive method, it is also possible to makes some improvement and supplements, these
Improve and supplement and also should be regarded as protection scope of the present invention.
Claims (7)
1. the preparation method of the 3 D stereo sticking patch of an individuation hemodynamics optimization, it is characterised in that
Described preparation method comprises the following steps: (1) gathers data acquisition three-dimensional digitalization model, and (2) are analyzed
Individuation virtual operation determines sticking patch design, and (3) utilize 3D printing technique to make sticking patch mould,
(4) sticking patch to be formed is positioned on mould convex surface, then fastens with mould curved surface, in it
Perfusion fixative, horizontal positioned molding to be fixed, remove mould after molding, i.e. obtain 3 D stereo sticking patch.
The preparation method of 3 D stereo sticking patch the most according to claim 1, it is characterised in that described
Step (1) is by obtaining the clinical MRI image data before operation in patients and supersonic blood metrical information,
Complete to treat that operated vessels area three-dimensional digital model is rebuild.
The preparation method of 3 D stereo sticking patch the most according to claim 1, it is characterised in that described
Step (2) is implanted for utilizing cad technique to implement virtual sticking patch, three-dimensional with different virtual operation designs
Model is Research foundation, carries out hemodynamics qualitative assessment and visualization display respectively, completes result of calculation
Analysis, the hemodynamics feature under different operation plans is compared.
The preparation method of 3 D stereo sticking patch the most according to claim 1, it is characterised in that described
Step (2) is implanted for utilizing cad technique to implement virtual sticking patch, three-dimensional with different virtual operation designs
Model is Research foundation, carries out hemodynamics qualitative assessment and visualization display respectively, completes result of calculation
Analysis, the hemodynamics feature under different operation plans is compared；Utilize computational fluid dynamics
Method, establishes blood flow movement computation model after accurate simulation vascular patch is implanted, implants three-dimensional reconstruction sticking patch
Regional vessel model carries out hemodynamics simulation and analysis；Use based on finite volume scheme calculating then
Hydrodynamics carries out Simulation of Blood；By computer realize pulsatile blood flow three-dimensional flow field consider Repiration,
Hemodynamics accurate simulation under vascular resistance, blood vessel elasticity physiological condition, and result of calculation carried out can
Process depending on change and compare, every kind of model sticking patch implantation position, shape, size and angle case are carried out comprehensively
Evaluate, find individual's optimal hemodynamics operation embodiment.
The preparation method of 3 D stereo sticking patch the most according to claim 1, it is characterised in that described
Step (4), for be positioned on mould convex surface by pericardium, then fastens with mould curved surface, fills in it
The fixing glutaraldehyde solution used of note pericardium sticking patch, horizontal positioned molding to be fixed, remove mould after molding and obtain
Obtain molded pericardium sticking patch, i.e. 3 D stereo sticking patch.
6. the 3 D stereo sticking patch that an individuation hemodynamics optimizes, it is characterised in that described three-dimensional
Three-dimensional patch prepares by the following method: (1) gathers data acquisition three-dimensional digitalization model, and (2) are analyzed individual
Body virtual operation determines sticking patch design, and (3) utilize 3D printing technique to make sticking patch mould,
(4) sticking patch to be formed is positioned on mould convex surface, then fastens with mould curved surface, in it
Perfusion fixative, horizontal positioned molding to be fixed, remove mould after molding, i.e. obtain 3 D stereo sticking patch.
3 D stereo sticking patch the most according to claim 6, it is characterised in that described 3 D stereo is mended
Sheet is applied in congenital heart disease operation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610280579.0A CN105997243A (en) | 2016-04-29 | 2016-04-29 | Application of three-dimensional vascular patch molding technology based on individualized hemodynamics optimization |
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| CN201610280579.0A CN105997243A (en) | 2016-04-29 | 2016-04-29 | Application of three-dimensional vascular patch molding technology based on individualized hemodynamics optimization |
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| CN105997243A true CN105997243A (en) | 2016-10-12 |
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| CN201610280579.0A Pending CN105997243A (en) | 2016-04-29 | 2016-04-29 | Application of three-dimensional vascular patch molding technology based on individualized hemodynamics optimization |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494716A (en) * | 2020-04-15 | 2020-08-07 | 青岛市妇女儿童医院（青岛市妇幼保健院、青岛市残疾儿童医疗康复中心、青岛市新生儿疾病筛查中心） | Heart surgery autologous pericardium patch processor and rapid anti-calcification treatment method |
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| US6352708B1 (en) * | 1999-10-14 | 2002-03-05 | The International Heart Institute Of Montana Foundation | Solution and method for treating autologous tissue for implant operation |
| CN1871998A (en) * | 2006-04-20 | 2006-12-06 | 北京思创贯宇科技开发有限公司 | Method and system for reconstructing 3 D blood vessels and posting virtual bracket |
| CN103917164A (en) * | 2011-08-26 | 2014-07-09 | Ebm株式会社 | Blood-vessel bloodstream simulation system, method therefor, and computer software program |
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2016
- 2016-04-29 CN CN201610280579.0A patent/CN105997243A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6352708B1 (en) * | 1999-10-14 | 2002-03-05 | The International Heart Institute Of Montana Foundation | Solution and method for treating autologous tissue for implant operation |
| CN1871998A (en) * | 2006-04-20 | 2006-12-06 | 北京思创贯宇科技开发有限公司 | Method and system for reconstructing 3 D blood vessels and posting virtual bracket |
| CN103917164A (en) * | 2011-08-26 | 2014-07-09 | Ebm株式会社 | Blood-vessel bloodstream simulation system, method therefor, and computer software program |
Non-Patent Citations (2)
| Title |
|---|
| KEREM PEKKAN等: "Patient-specific surgical planning and hemodynamic computational fluid dynamics optimization through free-form haptic anatomy editing tool (SURGEM)", 《MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING》 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494716A (en) * | 2020-04-15 | 2020-08-07 | 青岛市妇女儿童医院（青岛市妇幼保健院、青岛市残疾儿童医疗康复中心、青岛市新生儿疾病筛查中心） | Heart surgery autologous pericardium patch processor and rapid anti-calcification treatment method |
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Application publication date: 20161012 |
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