CN105979942B - 用于治疗或缓解疼痛的氨基磺酸酯衍生物 - Google Patents
用于治疗或缓解疼痛的氨基磺酸酯衍生物 Download PDFInfo
- Publication number
- CN105979942B CN105979942B CN201480075292.3A CN201480075292A CN105979942B CN 105979942 B CN105979942 B CN 105979942B CN 201480075292 A CN201480075292 A CN 201480075292A CN 105979942 B CN105979942 B CN 105979942B
- Authority
- CN
- China
- Prior art keywords
- benzo
- chloro
- methylsulfamate
- dimethyl
- dioxane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C(C1)C2C1[*+]**2 Chemical compound C(C1)C2C1[*+]**2 0.000 description 12
- GELHONVKBCQCPO-UHFFFAOYSA-N CC(C)(OC(CO)C1)Oc2c1cccc2 Chemical compound CC(C)(OC(CO)C1)Oc2c1cccc2 GELHONVKBCQCPO-UHFFFAOYSA-N 0.000 description 1
- ZCNCGWNFQOQUKU-UHFFFAOYSA-N CC(C1OC2(CCCCC2)Oc2c1cccc2Cl)=O Chemical compound CC(C1OC2(CCCCC2)Oc2c1cccc2Cl)=O ZCNCGWNFQOQUKU-UHFFFAOYSA-N 0.000 description 1
- SGWWXXHNJGGRCJ-ZEVBXJOLSA-N CCC(CC)(O[C@@H]1C(O[C@H](C[C@H](C)CC2)[C@@H]2C(C)C)=O)Oc2c1cccc2Cl Chemical compound CCC(CC)(O[C@@H]1C(O[C@H](C[C@H](C)CC2)[C@@H]2C(C)C)=O)Oc2c1cccc2Cl SGWWXXHNJGGRCJ-ZEVBXJOLSA-N 0.000 description 1
- CTCLSNALIUTPNY-UHFFFAOYSA-N CCC1(CC)Oc2ccccc2C(CCOCC)O1 Chemical compound CCC1(CC)Oc2ccccc2C(CCOCC)O1 CTCLSNALIUTPNY-UHFFFAOYSA-N 0.000 description 1
- MERYNIQLJGXKRP-LBPRGKRZSA-N CCC1(CC)Oc2ccccc2[C@H](CO)O1 Chemical compound CCC1(CC)Oc2ccccc2[C@H](CO)O1 MERYNIQLJGXKRP-LBPRGKRZSA-N 0.000 description 1
- YBWPIBCXNILAOK-UHFFFAOYSA-N CCC1(CC)[O]=C(CO)c(cccc2)c2O1 Chemical compound CCC1(CC)[O]=C(CO)c(cccc2)c2O1 YBWPIBCXNILAOK-UHFFFAOYSA-N 0.000 description 1
- PNGINJSOXXYTJQ-UHFFFAOYSA-N CCOC(C(c1cc(OC)ccc1O)O)=O Chemical compound CCOC(C(c1cc(OC)ccc1O)O)=O PNGINJSOXXYTJQ-UHFFFAOYSA-N 0.000 description 1
- YGYCGINIPUHKNN-UHFFFAOYSA-N CCOC(C1OC(C)(C)Oc2c1ccc(Cl)c2)=O Chemical compound CCOC(C1OC(C)(C)Oc2c1ccc(Cl)c2)=O YGYCGINIPUHKNN-UHFFFAOYSA-N 0.000 description 1
- UHGCFNXBCYMXCE-UHFFFAOYSA-N CCOC(CC(Cc(cccc1)c1O)O)=O Chemical compound CCOC(CC(Cc(cccc1)c1O)O)=O UHGCFNXBCYMXCE-UHFFFAOYSA-N 0.000 description 1
- MACKIUCDTSRWEB-UHFFFAOYSA-N CC[O](C)C(CC(Cc(cccc1Cl)c1OCc1ccccc1)O)=O Chemical compound CC[O](C)C(CC(Cc(cccc1Cl)c1OCc1ccccc1)O)=O MACKIUCDTSRWEB-UHFFFAOYSA-N 0.000 description 1
- GLYKPUKGHUZRKD-UHFFFAOYSA-N OCC1OC2(CCCCC2)Oc2c1cccc2Cl Chemical compound OCC1OC2(CCCCC2)Oc2c1cccc2Cl GLYKPUKGHUZRKD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361915042P | 2013-12-12 | 2013-12-12 | |
| US61/915,042 | 2013-12-12 | ||
| PCT/KR2014/012260 WO2015088272A1 (en) | 2013-12-12 | 2014-12-12 | Sulfamate derivative compounds for use in treating or alleviating pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105979942A CN105979942A (zh) | 2016-09-28 |
| CN105979942B true CN105979942B (zh) | 2018-12-07 |
Family
ID=53371494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480075292.3A Expired - Fee Related CN105979942B (zh) | 2013-12-12 | 2014-12-12 | 用于治疗或缓解疼痛的氨基磺酸酯衍生物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10081615B2 (enExample) |
| EP (1) | EP3079687B1 (enExample) |
| JP (1) | JP6311025B2 (enExample) |
| KR (1) | KR101758583B1 (enExample) |
| CN (1) | CN105979942B (enExample) |
| ES (1) | ES2663804T3 (enExample) |
| WO (1) | WO2015088272A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9834535B2 (en) * | 2013-12-12 | 2017-12-05 | Bio-Pharm Solutions Co., Ltd. | Sulfamate derivative compounds for use in treating or alleviating pain |
| US10351519B2 (en) * | 2016-02-29 | 2019-07-16 | Bio-Pharm Solutions Co., Ltd. | Sulfamate derivative compounds, processes for preparing them and their uses |
| CN114350340B (zh) * | 2022-01-13 | 2023-01-17 | 陕西科技大学 | 一种压裂用增渗剂及其制备方法和应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998380A (en) * | 1995-10-13 | 1999-12-07 | New England Medical Center Hospitals, Inc. | Treatment of migraine |
| WO2008054291A1 (en) * | 2006-11-01 | 2008-05-08 | Astrazeneca Ab | Pyrazolyl derivatives with analgesic activity and therefore useful in the treatment or prophylaxis of pain. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582916A (en) | 1983-09-26 | 1986-04-15 | Mcneilab, Inc. | Chlorosulfate and azidosulfate esters of tetrahydro-2H-pyran-2-yl-methanol |
| US4591601A (en) * | 1985-04-12 | 1986-05-27 | Mcneilab, Inc. | Anticonvulsant dioxolane methane sulfamates |
| ATE63912T1 (de) * | 1987-02-05 | 1991-06-15 | Caber Farmaceutici | 4-oxo-1,3-benzodioxan-derivat. |
| US4792569A (en) | 1987-08-27 | 1988-12-20 | Mcneilab, Inc. | Anticonvulsant phenethyl sulfamates |
| MY147767A (en) | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| US8492372B2 (en) * | 2008-04-29 | 2013-07-23 | Integrated Research Laboratories Sweden Ab | Modulators of dopamine neurotransmission |
| US8815939B2 (en) * | 2008-07-22 | 2014-08-26 | Janssen Pharmaceutica Nv | Substituted sulfamide derivatives |
| EA201300558A1 (ru) * | 2010-11-11 | 2013-11-29 | Акрон Моликьюлис Гмбх | Соединения и способы для купирования боли |
| CN104428292B (zh) | 2012-06-15 | 2017-02-08 | 生物药品解决方案有限公司 | 氨基磺酸苯基烷基酯化合物及包含所述化合物的肌肉松弛组合物 |
-
2014
- 2014-12-12 EP EP14869914.3A patent/EP3079687B1/en active Active
- 2014-12-12 WO PCT/KR2014/012260 patent/WO2015088272A1/en not_active Ceased
- 2014-12-12 ES ES14869914.3T patent/ES2663804T3/es active Active
- 2014-12-12 US US15/103,595 patent/US10081615B2/en active Active
- 2014-12-12 CN CN201480075292.3A patent/CN105979942B/zh not_active Expired - Fee Related
- 2014-12-12 JP JP2016538526A patent/JP6311025B2/ja not_active Expired - Fee Related
- 2014-12-12 KR KR1020167013586A patent/KR101758583B1/ko active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998380A (en) * | 1995-10-13 | 1999-12-07 | New England Medical Center Hospitals, Inc. | Treatment of migraine |
| WO2008054291A1 (en) * | 2006-11-01 | 2008-05-08 | Astrazeneca Ab | Pyrazolyl derivatives with analgesic activity and therefore useful in the treatment or prophylaxis of pain. |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20160065984A (ko) | 2016-06-09 |
| EP3079687A1 (en) | 2016-10-19 |
| EP3079687A4 (en) | 2017-04-26 |
| US10081615B2 (en) | 2018-09-25 |
| CN105979942A (zh) | 2016-09-28 |
| US20160311792A1 (en) | 2016-10-27 |
| WO2015088272A1 (en) | 2015-06-18 |
| JP6311025B2 (ja) | 2018-04-11 |
| WO2015088272A9 (en) | 2015-10-01 |
| KR101758583B1 (ko) | 2017-07-14 |
| ES2663804T3 (es) | 2018-04-17 |
| EP3079687B1 (en) | 2018-02-28 |
| JP2017509582A (ja) | 2017-04-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2017371134B2 (en) | Pharmaceutical composition for preventing or treating liver cancer, comprising tetraarsenic hexoxide crystalline polymorph | |
| RU2676766C2 (ru) | Функционализованные соединения бензопирана и их применение | |
| TW201028142A (en) | Heterobicyclic sphingosine 1-phosphate analogs | |
| CN105792821B (zh) | 包含1-茚满硫酰胺衍生物的疼痛治疗剂和/或预防剂 | |
| CN105979942B (zh) | 用于治疗或缓解疼痛的氨基磺酸酯衍生物 | |
| CN102344442A (zh) | 枸橼酸坦度螺酮的新晶型及其制备方法和用途 | |
| US11958821B2 (en) | Phenethylamine compounds salts, polymorphic forms and methods of use thereof | |
| TWI859303B (zh) | 受體作動活性的化合物的鹽及結晶形 | |
| CN110092775A (zh) | 靶向cdk4/6激酶抑制剂的晶型 | |
| CN1868998A (zh) | β－(3,4－二羟基苯基)－α－羟基丙酸冰片酯、其合成方法和用途 | |
| CN101830896B (zh) | 戊乙奎醚光学异构体的有机酸盐 | |
| CA3255938A1 (en) | Crystalline forms of quinolone analogs and their salts | |
| JP2014141524A (ja) | ニコサミド（Ｎｉｃｏｕｓａｍｉｄｅ）化合物の五つの晶型、その製法やその薬物組合と用途 | |
| WO2017124949A1 (zh) | 二氢黄酮衍生物、其制备方法和用途 | |
| JP2015522541A (ja) | （１Ｒ−ｔｒａｎｓ）−Ｎ−［［２−（２，３−ジヒドロ−４−ベンゾフラニル）シクロプロピル］メチル］プロパンアミドの代謝物 | |
| KR20220103977A (ko) | 에스트로겐 수용체 조절제의 염 및 형태 | |
| CN106699771A (zh) | 隐丹参酮类化合物、制备方法和用途 | |
| CN107216283B (zh) | 一种含有二氢吡啶结构的β-榄香烯衍生物及其制备方法和用途 | |
| CN102992988B (zh) | 一种取代间苯三酚衍生物及其应用 | |
| IL309986A (en) | Methods of treating estrogen receptor-associated diseases | |
| US20210147367A1 (en) | Crystalline forms of a magl inhibitor | |
| JP2007506714A (ja) | 神経向性薬として利用可能なハイドロキシル化された長鎖をもつトコフェノール誘導体 | |
| CN105646461B (zh) | S构型4-(取代苯胺基)喹唑啉衍生物及其制备方法和用途 | |
| CN116751186B (zh) | 一种雌激素受体调节剂的制备及其用途 | |
| CN105439889B (zh) | 一种香兰素胺类新化合物、其制备方法及医药用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20181207 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |