CN105963646A - Traditional Chinese medicinal micro-ecological preparation for treating endometritis of sows and preparation method thereof - Google Patents
Traditional Chinese medicinal micro-ecological preparation for treating endometritis of sows and preparation method thereof Download PDFInfo
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- CN105963646A CN105963646A CN201610562231.0A CN201610562231A CN105963646A CN 105963646 A CN105963646 A CN 105963646A CN 201610562231 A CN201610562231 A CN 201610562231A CN 105963646 A CN105963646 A CN 105963646A
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/296—Epimedium
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a traditional Chinese medicinal micro-ecological preparation for treating endometritis of sows and a preparation method thereof. The preparation is prepared from the following traditional Chinese medicinal materials in parts by weight: 50-70 parts of ash bark, 20-30 parts of rhizoma atractylodis macrocephalae, 20-30 parts of rhizoma corydalis, 15-20 parts of poria cocos, 10-15 parts of echinacea, 10-15 parts of radix achyranthis bidentatae, 10-20 parts of herba euphorbiae humifusae, 20-30 parts of ixeris chinensis, 10-20 parts of glossy privet leaves, 10-20 parts of herba epimedii, 5-7 parts of curcuma zedoary and 5-10 parts of semen trigonellae. The traditional Chinese medicinal micro-ecological preparation has an exact curative effect and no toxic or side effect, can be used for effectively curing endometritis of the sows without relapse, enhancing the ovary functions of the sows and improving body immunity, and has a good treatment effect on infertility of the sows.
Description
Technical field
The present invention relates to veterinary drug technical field, particularly relate to one and treat Gilt Uterus intimitis Traditional Chinese drug microecology system
Agent and preparation method.
Background technology
Gilt Uterus intimitis is the inflammation of Gilt Uterus mucosa, is the commonly encountered diseases of Sow Genital Organs, also leads
Cause the major reason of sow Repeat breeding, pig industry is caused the biggest economic loss.Endometritis can cause
Involution of uterus time lengthening, makes conception rate decline, and causes infertile, goes back long-time stimulus uterus inwall sensor simultaneously,
By reflection, making hormonal regulation lack of proper care, cause ovarian disease, have also excites mastitis.
Treatment Gilt Uterus intimitis all uses antibiotic at present, and treatment cycle is long, and therapeutic effect is unstable, and
And owing to antibiotic uses the most in a large number, on the one hand cause Resistant strain to increase, on the other hand antibiotic in sow
The food-safety problem that residual is brought the most increasingly is paid close attention to by people.Therefore safe prevention Gilt Uterus inner membrance
The scorching attention increasingly causing people.
Summary of the invention
The invention aims to overcome the deficiencies in the prior art, it is provided that one is treated in Gilt Uterus intimitis
Medicine microbial ecological agent, compound compatibility famous-brand and high-quality Chinese crude drug component and ratio, give full play to Chinese medicine multicomponent, multiple location,
The comprehensive therapeutic effect of Mutiple Targets, determined curative effect and having no side effect, rich in Chinese herbal medicine active substance, active small peptide,
Lactic acid and probiotic bacteria, can effectively cure Gilt Uterus intimitis and be difficult to recurrence, strengthening sow ovarian function simultaneously,
Improve autoimmunity, sow infertility is also had good therapeutic effect.
The present invention also provides for the preparation method of this treatment Gilt Uterus intimitis Chinese medicine microecological preparation.
To achieve these goals, the present invention adopts the following technical scheme that
One treats Gilt Uterus intimitis Chinese medicine microecological preparation, is made up of the Chinese medicine of following weight portion: Cortex Fraxini
50-70 part, Rhizoma Atractylodis Macrocephalae 20-30 part, Rhizoma Corydalis 20-30 part, Poria 15-20 part, Echinacea 10-15 part, cattle
Knee joint 10-15 part, Herba Euphorbiae Humifusae 10-20 part, Herba Ixeritis chinensis 20-30 part, Folium Ligustri Lucidi 10-20 part, Herba Epimedii 10-20
Part, Rhizoma Curcumae 5-7 part, reed Ba Zi 5-10 part.
Preferably, described treatment Gilt Uterus intimitis Chinese medicine microecological preparation, by the Chinese medicine of following weight portion
Make: Cortex Fraxini 60 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Rhizoma Corydalis 25 parts, 20 parts of Poria, Echinacea 12 parts, Radix Achyranthis Bidentatae 12
Part, Herba Euphorbiae Humifusae 15 parts, Herba Ixeritis chinensis 25 parts, the Folium Ligustri Lucidi 15 parts, Folium Cinnamomi porrecti Herba Epimedii 15 parts, Rhizoma Curcumae 6
Part, reed Ba Zi 8 parts.
The preparation method of described treatment Gilt Uterus intimitis Chinese medicine microecological preparation, comprises the following steps:
(1) each Chinese medicine is weighed by above-mentioned weight ratio, by each Study on Supermicro-pulverization of Traditional Chinese Drugs；
(2) adding the water of Chinese medicine gross weight 5-7 times amount, soak 30-50min, intense fire boils, and slow fire is incubated
30-60min, cold filtration；Filtering residue adds the water of 4-5 times amount, and intense fire boils, slow fire insulation 30-60min,
Cold filtration, merges twice filtrate；
(3) collect filtrate, in filtrate, add the white sugar of its weight 20%, and boil 5-10min, be cooled to
Room temperature, the inoculation lactobacillus of filtrate weight 20%, red tea fungus and yeast preparation, ferment, during fermentation
Between be 3-5 days, fermentation temperature is 35-37 DEG C, obtains microbial ecological agent.
When the present invention uses, drink directly to sow after microbial ecological agent dilute with water 5-10 times.
In the present invention, Cortex Fraxini, there is broad-spectrum antiseptic, antivirus action；The Rhizoma Atractylodis Macrocephalae, has invigorating the spleen and benefiting QI, dampness
Diuretic, hidroschesis, antiabortive effect；Rhizoma Corydalis, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, for whole body each portion qi depression to blood stasis it
Bitterly, dysmenorrhea, amenorrhea, postpartum stagnation；Poria, has eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming；
Echinacea, has the effect improving immunity；Radix Achyranthis Bidentatae, has dysmenorrhea of invigorating blood circulation, and ignites descending, inducing diuresis for treating stranguria syndrome
Effect；Herba Euphorbiae Humifusae, has heat-clearing and toxic substances removing, cooling blood for hemostasis effect；Herba Ixeritis chinensis, heat clearing away deciphering, stasis-dispelling and pain-killing,
For puerperal abdonimal pain, dysmenorrhea, chest and abdomen pain；The Folium Ligustri Lucidi, containing triterpenes, secoiridiod, flavone
The materials such as class, polysaccharide, phenylethanol, volatile oil, triterpenes components master contains ursolic acid and oleanolic acid, energy
Remarkably promote the absorption of calcium, preventing and treating retarded growth and osteoporosis, have and protect the liver profit kidney and improve ovary
Function；Herba Epimedii, has the effect stimulating follicular cell secretion estradiol；Rhizoma Curcumae, has circulation of qi promoting and breaks
Blood, effect of removing food stagnancy pain relieving, for congestion amenorrhea, food stagnation distending pain, early cervical carcinoma.
Compared with the prior art, beneficial effects of the present invention is as follows:
The treatment Gilt Uterus intimitis Chinese medicine microecological preparation of the present invention, compound compatibility famous-brand and high-quality Chinese crude drug component and
Ratio, gives full play to the comprehensive therapeutic effect of Chinese medicine multicomponent, multiple location, Mutiple Targets, determined curative effect and nontoxic secondary work
With, rich in Chinese herbal medicine active substance, active small peptide, lactic acid and probiotic bacteria, can effectively cure Gilt Uterus inner membrance
Scorching and be difficult to recurrence, strengthen sow ovarian function simultaneously, improve autoimmunity, sow infertility is also had very
Good therapeutic effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated, but the present invention is not limited only to these embodiments,
On the premise of without departing from present inventive concept, within any improvement made all falls within protection scope of the present invention.
Embodiment 1:
One treats Gilt Uterus intimitis Chinese medicine microecological preparation, is made up of the Chinese medicine of following weight portion: Cortex Fraxini
50 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Rhizoma Corydalis 20 parts, 20 parts of Poria, Echinacea 10 parts, Radix Achyranthis Bidentatae 15 parts, Herba Euphorbiae Humifusae
10 parts, Herba Ixeritis chinensis 20 parts, the Folium Ligustri Lucidi 20 parts, Herba Epimedii 10 parts, Rhizoma Curcumae 5 parts, reed Ba Zi 10 parts.
The preparation method of described treatment Gilt Uterus intimitis Chinese medicine microecological preparation, comprises the following steps:
(1) each Chinese medicine is weighed by above-mentioned weight ratio, by each Study on Supermicro-pulverization of Traditional Chinese Drugs；
(2) adding the water of Chinese medicine gross weight 5 times amount, soak 50min, intense fire boils, slow fire insulation 30min,
Cold filtration；Filtering residue adds the water of 5 times amount, and intense fire boils, slow fire insulation 30min, and cold filtration merges twice
Filtrate；
(3) collect filtrate, in filtrate, add the white sugar of its weight 20%, and boil 5min, be often cooled to
Temperature, the inoculation lactobacillus of filtrate weight 20%, red tea fungus and yeast preparation, ferment, fermentation time
Being 3 days, fermentation temperature is 37 DEG C, obtains microbial ecological agent.
Embodiment 2:
One treats Gilt Uterus intimitis Chinese medicine microecological preparation, is made up of the Chinese medicine of following weight portion: Cortex Fraxini
60 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Rhizoma Corydalis 25 parts, 20 parts of Poria, Echinacea 12 parts, Radix Achyranthis Bidentatae 12 parts, Herba Euphorbiae Humifusae
15 parts, Herba Ixeritis chinensis 25 parts, the Folium Ligustri Lucidi 15 parts, Folium Cinnamomi porrecti Herba Epimedii 15 parts, Rhizoma Curcumae 6 parts, reed Ba Zi 8
Part.
The preparation method of described treatment Gilt Uterus intimitis Chinese medicine microecological preparation, comprises the following steps:
(1) each Chinese medicine is weighed by above-mentioned weight ratio, by each Study on Supermicro-pulverization of Traditional Chinese Drugs；
(2) adding the water of Chinese medicine gross weight 6 times amount, soak 40min, intense fire boils, slow fire insulation 50min,
Cold filtration；Filtering residue adds the water of 5 times amount, and intense fire boils, slow fire insulation 50min, and cold filtration merges twice
Filtrate；
(3) collect filtrate, in filtrate, add the white sugar of its weight 20%, and boil 8min, be often cooled to
Temperature, the inoculation lactobacillus of filtrate weight 20%, red tea fungus and yeast preparation, ferment, fermentation time
Being 4 days, fermentation temperature is 36 DEG C, obtains microbial ecological agent.
Embodiment 3:
One treats Gilt Uterus intimitis Chinese medicine microecological preparation, is made up of the Chinese medicine of following weight portion: Cortex Fraxini
70 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Rhizoma Corydalis 30 parts, 20 parts of Poria, Echinacea 15 parts, Radix Achyranthis Bidentatae 15 parts, Herba Euphorbiae Humifusae
10 parts, Herba Ixeritis chinensis 30 parts, the Folium Ligustri Lucidi 10 parts, Herba Epimedii 20 parts, Rhizoma Curcumae 7 parts, reed Ba Zi 10 parts.
The preparation method of described treatment Gilt Uterus intimitis Chinese medicine microecological preparation, comprises the following steps:
(1) each Chinese medicine is weighed by above-mentioned weight ratio, by each Study on Supermicro-pulverization of Traditional Chinese Drugs；
(2) adding the water of Chinese medicine gross weight 7 times amount, soak 50min, intense fire boils, slow fire insulation 60min,
Cold filtration；Filtering residue adds the water of 5 times amount, and intense fire boils, slow fire insulation 60min, and cold filtration merges twice
Filtrate；
(3) collect filtrate, in filtrate, add the white sugar of its weight 20%, and boil 10min, be often cooled to
Temperature, the inoculation lactobacillus of filtrate weight 20%, red tea fungus and yeast preparation, ferment, fermentation time
Being 5 days, fermentation temperature is 37 DEG C, obtains microbial ecological agent.
Test example:
1, trial drug: the microbial ecological agent of embodiment 1,2,3 and antibiotic.
2, case load and case selection standard
(1) acute endometritis case: 20, puerperal or 10 days post-abortions, clinical symptoms is disease temperature of pig body
Raise, subtract food or do not eat and be reluctant to stand up, with micturition, glue from the bronzing of intravaginal elution band stink
Liquid or purulent secretion, have accompanies afterbirth fragment.
(2) chronic endometritis case: 20, it is the same from phase that case derives from acute endometritis case
Same pig farm, and ill more than 20 day sow invalid through antibiotic therapy.
3, test packet:
The sow that 40 suffer from endometritis is randomly divided into 4 groups, often group 10 (5 are acute, 5
Chronic) wherein tri-test group of A, B, C, the microbial ecological agent using medicine to be embodiment 1,2,3；
D group is matched group, and medicine is antibiotic group (penicillin 1,600,000 unit, streptomycin 5,000,000 units/head/time).
4, medication
A, B, C group, will drink directly to sow after the microbial ecological agent dilute with water 5 times of embodiment 1,2,3
With；Every day 1 time, continuous use 5 days, 5 days is 1 course for the treatment of；Matched group, medication every day 1 time, it is used in conjunction
It it is for 5 times 1 course for the treatment of.
5, efficacy determination method and standard:
(1) curing: inflammation of uterus disappears, intrauterine is discharged without rheuminess thing and pus, and uterus is just being recovered
Often, secretions transparent clear, oestrus on schedule, normal pregnancy.
(2) effective: inflammation of uterus is substantially alleviated, uterine secretion thing is close to normal, before and after bacteria distribution is identified
Comparison, main or fraction of pathogens bacterium eliminates.
(3) invalid: inflammation of uterus has no light and slow, uterine secretion thing has no that improvement even deteriorates, bacteria distribution table
Bright have other pathogenic bacterial infections.
6, coherence check is carried out after the course for the treatment of, inspection result such as table 1 below:
Table 1 therapeutic effect compares:
| Group | Treatment number of cases | Cure number of cases | Effectively number of cases | Invalid number of cases | Cure rate % |
| A | 10 | 8 | 2 | 0 | 80% |
| B | 10 | 10 | 0 | 0 | 100% |
| C | 10 | 9 | 1 | 0 | 90% |
| D matched group | 10 | 3 | 5 | 2 | 30% |
Finding out from upper table 1 result, the antibiotic therapy method that the Chinese medicine microecological preparation of the present invention is more traditional has bright
Aobvious raising, reaches good treatment effect.
Claims (3)
1. a treatment Gilt Uterus intimitis Chinese medicine microecological preparation, it is characterised in that: by following weight portion
Chinese medicine make: Cortex Fraxini 50-70 part, Rhizoma Atractylodis Macrocephalae 20-30 part, Rhizoma Corydalis 20-30 part, Poria 15-20 part, purple
Cone chrysanthemum 10-15 part, Radix Achyranthis Bidentatae 10-15 part, Herba Euphorbiae Humifusae 10-20 part, Herba Ixeritis chinensis 20-30 part, Folium Ligustri Lucidi 10-20
Part, Herba Epimedii 10-20 part, Rhizoma Curcumae 5-7 part, reed Ba Zi 5-10 part.
Treatment Gilt Uterus intimitis Chinese medicine microecological preparation the most according to claim 1, its feature exists
In: it is made up of the Chinese medicine of following weight portion: Cortex Fraxini 60 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Rhizoma Corydalis 25 parts, Poria 20
Part, Echinacea 12 parts, Radix Achyranthis Bidentatae 12 parts, Herba Euphorbiae Humifusae 15 parts, Herba Ixeritis chinensis 25 parts, the Folium Ligustri Lucidi 15 parts are fragrant
Leaf of Lignum cinnamomi camphorae Herba Epimedii 15 parts, Rhizoma Curcumae 6 parts, reed Ba Zi 8 parts.
The preparation method for the treatment of Gilt Uterus intimitis Chinese medicine microecological preparation the most according to claim 1,
It is characterized in that: comprise the following steps:
(1) each Chinese medicine is weighed by above-mentioned weight ratio, by each Study on Supermicro-pulverization of Traditional Chinese Drugs；
(2) adding the water of Chinese medicine gross weight 5-7 times amount, soak 30-50min, intense fire boils, and slow fire is incubated
30-60min, cold filtration；Filtering residue adds the water of 4-5 times amount, and intense fire boils, slow fire insulation 30-60min,
Cold filtration, merges twice filtrate；
(3) collect filtrate, in filtrate, add the white sugar of its weight 20%, and boil 5-10min, be cooled to
Room temperature, the inoculation lactobacillus of filtrate weight 20%, red tea fungus and yeast preparation, ferment, during fermentation
Between be 3-5 days, fermentation temperature is 35-37 DEG C, obtains microbial ecological agent.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104012798A (en) * | 2014-06-04 | 2014-09-03 | 山东新希望六和集团有限公司 | Feed for treating endometritis of sow, traditional Chinese medicine composition and preparation method |
| CN104127534A (en) * | 2014-08-26 | 2014-11-05 | 郭庆 | Preparation method of traditional Chinese medicine microecological preparation for preventing endometritis of dairy cattle |
| CN105641081A (en) * | 2016-01-18 | 2016-06-08 | 湖南广安动物保健品有限公司 | Traditional Chinese medicine oral liquid for treating sow endometritis |
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2016
- 2016-07-18 CN CN201610562231.0A patent/CN105963646A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104012798A (en) * | 2014-06-04 | 2014-09-03 | 山东新希望六和集团有限公司 | Feed for treating endometritis of sow, traditional Chinese medicine composition and preparation method |
| CN104127534A (en) * | 2014-08-26 | 2014-11-05 | 郭庆 | Preparation method of traditional Chinese medicine microecological preparation for preventing endometritis of dairy cattle |
| CN105641081A (en) * | 2016-01-18 | 2016-06-08 | 湖南广安动物保健品有限公司 | Traditional Chinese medicine oral liquid for treating sow endometritis |
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Application publication date: 20160928 |