CN105943920A - Traditional Chinese medicine preparation for preventing and relieving side effects of iodic contrast agent - Google Patents

Traditional Chinese medicine preparation for preventing and relieving side effects of iodic contrast agent Download PDF

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CN105943920A
CN105943920A CN201610482201.9A CN201610482201A CN105943920A CN 105943920 A CN105943920 A CN 105943920A CN 201610482201 A CN201610482201 A CN 201610482201A CN 105943920 A CN105943920 A CN 105943920A
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chinese medicine
herba
medicine preparation
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刘子成
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/51Gentianaceae (Gentian family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
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Abstract

The invention relates to a traditional Chinese medicine preparation which is applied to the use in clinical examination of a medical imaging department, in particular to a traditional Chinese medicine preparation for preventing and relieving side effects of an iodic contrast agent. The traditional Chinese medicine preparation is prepared from the traditional Chinese medicine raw materials as follows: 25-30 parts of herba fici, 10-15 parts of canscora lucidissima, 10-15 parts of Clerodendrum fortunatum, 10-15 parts of tender catchweed bedstraw herb, 5-10 parts of Cyathocline purpurea, 25-30 parts of rhizoma imperatae, 10-15 parts of entadae stems, 10-15 parts of zinnia, 10-15 parts of herba Lysimachia barystachys Bunge, 10-15 parts of oyster, and 5-10 parts of monkshood. The traditional Chinese medicine preparation has the advantages that the used traditional Chinese medicines meet regulations in Pharmacopoeia of the People's Republic of China, and the medicines are safe and reliable. The medicines are matched to prevent and relieve side effects during or after use of the iodic contrast agent, and the traditional Chinese medicine preparation has the characteristics of being definite in curative effect, rapid in effect taking, high in curative ratio, free from side effects, and the like.

Description

A kind of Chinese medicine preparation preventing to alleviate diodone side effect
Technical field
The present invention relates to a kind of Chinese medicine preparation, tool is applied in Medical Imaging Department clinical examination use, and is specifically related to a kind of pre-anti-slow Solve the Chinese medicine preparation of diodone side effect.
Background technology
Contrast agent is to inject (or taking) to tissue or the chemicals of organ for strengthening Imaging Study effect.These systems The density of product is higher or lower than surrounding tissue, and the contrast of formation shows image with some apparatus.Operand as conventional in x-ray observation, Barium sulfate etc..Wherein, the development experience of diodone is from inorganic iodine to organic iodine, from an iodine, diiodo-to triiodo, from ion Type is to stages such as nonionics.The ionic comonomer contrast agent stable in properties that the 1950's develops, contrast is good, but its Osmotic pressure is high, and toxicity is bigger.The nonionic with Omnipaque, Ultravist as representative that the eighties in 20th century develops Monomer contrast agent, is the derivant of Triiodobenzoic acid.It is with the difference of ionic comonomer contrast agent: remove cation, reduces Infiltration toxicity;Remove carboxyl, reduce neurotoxicity;Add 4~6 hydroxyls, increase hydrophilic, improve water-soluble degree, reduce viscous Degree and chemical toxicity.It is widely used for heart, angiography and CT enhanced ct scans at present.
In use or also can there is certain side effect after using in diodone, severity of symptom differs, and serious symptom can Fatal.Process to reaction to determine according to different symptoms and light and heavy degree.General the lighter is not required to process, but wants close observation Its development, the symptom such as mild nausea, vomiting can be the tendency of severe reaction sometimes.Moderate is reacted such as: vomiting dizzy, serious, Feel cold, whole body popularity urticaria, face or laryngeal edema, bronchospasm, chest pain out of breath, suffer from abdominal pain, have a headache and limbs are taken out The reaction anti symptom treatment such as jerk.Severe reaction such as serious collapse, unconsciousness, pulmonary edema, heart stopping collecting or ventricular fibrillation, seriously Arrhythmia and myocardial infarction etc. must be rescued immediately.Treat based on to the ill, give antiallergic, hormone, spasmolytic boosting Deng medicine and oxygen therapy, sustain life organ dysfunction.Different contrast agent untoward reaction inequalities, key can identify early, processes In time.
Summary of the invention
According to above the deficiencies in the prior art, the present invention provides a kind of Chinese medicine preparation preventing to alleviate diodone side effect, it is possible to The side effect produced in prevention or the in time use of alleviation diodone or after use, its secondary work evident in efficacy, safe and reliable, nontoxic With, there is wide potential applicability in clinical practice.
A kind of Chinese medicine preparation preventing to alleviate diodone side effect of the present invention, it is characterised in that in parts by weight, It is prepared from by following raw material of Chinese medicine: Caulis et Folium fici Tikouae 25~30 parts, Herba Canscorae 10~15 parts, Herba Clerodendri fortunati 10~15 parts, Herba Galii Teneri 10~15 part, glass chrysanthemums 5~10 parts, Rhizoma Imperatae 25~30 parts, Caulis Entadae 10~15 parts, youth-and-old-age 10~15 parts, XUEJINGCAO 10~15 Part, Concha Ostreae 10~15 parts, Radix Aconiti Lateralis Preparata 5~10 parts.
Wherein, preferred version is as follows:
Can be in parts by weight, following raw material of Chinese medicine be prepared from: Caulis et Folium fici Tikouae 25 parts, Herba Canscorae 10 parts, spend in vain 10 parts of lantern, Herba Galii Teneri 10 part, glass chrysanthemum 5 parts, Rhizoma Imperatae 25 parts, Caulis Entadae 10 parts, youth-and-old-age 10 parts, XUEJINGCAO 10 parts, Concha Ostreae 10 parts, Radix Aconiti Lateralis Preparata 5 parts.
Can also be in parts by weight, following raw material of Chinese medicine be prepared from: be Caulis et Folium fici Tikouae 30 parts, Herba Canscorae 15 parts, white 15 parts of festive lantern cage, Herba Galii Teneri 15 part, glass chrysanthemum 10 parts, Rhizoma Imperatae 30 parts, Caulis Entadae 15 parts, youth-and-old-age 15 parts, blood warp Grass 15 parts, Concha Ostreae 15 parts, Radix Aconiti Lateralis Preparata 10 parts.
Can also be in parts by weight, following raw material of Chinese medicine be prepared from: be Caulis et Folium fici Tikouae 28 parts, Herba Canscorae 12 parts, white 12 parts of festive lantern cage, Herba Galii Teneri 12 part, glass chrysanthemum 8 parts, Rhizoma Imperatae 28 parts, Caulis Entadae 12 parts, youth-and-old-age 12 parts, XUEJINGCAO 12 parts, Concha Ostreae 12 parts, Radix Aconiti Lateralis Preparata 8 parts.
The preparation method of the Chinese medicine preparation of diodone side effect is alleviated in prevention of the present invention, prepares in accordance with the following methods: press Weigh raw material of Chinese medicine according to formula and join in container, adding water and cover powder immersion 10~20 minutes, added water no powder 3~5 Centimetre, decoct with high heat and use slow fire boiling 20~30 minutes again instead to boiling, take filtrate;Then add water not powder 3~5 lis Rice, decocts with high heat and uses slow fire boiling 15~20 minutes again instead to boiling, then remove slag and take filtrate, and twice filtrate merges.
When taking, each 300ml, one day twice.
Pharmacology analysis:
Caulis et Folium fici Tikouae: bitter, cold.Heat clearing away, dampness removing, invigorate blood circulation, removing toxic substances.Control cough due to pathogenic wind-heat, dysentery, edema, jaundice, arthritis pain Bitterly, bleeding hemorrhoids, amenorrhea, leukorrhagia, infantile dyspepsia, traumatic injury, innominate toxic swelling.
Herba Canscorae: mildly bitter flavor, cool in nature.Heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.Control cough due to lung-heat, hepatitis, leptospirosis, Huang Subcutaneous ulcer, chest pain, stomachache, the stasis of blood in traumatic injury, venom.
Herba Clerodendri fortunati: micro-hardship is cool.Heat-clearing and toxic substances removing, cough-relieving analgesic therapy.For cold, fever, pharyngolaryngitis, bronchitis, lung is tied Core hectic fever, stomachache, colic;Traumatic injury, furuncle furuncle and phyma.
Herba Galii Teneri: toil, cold.Clearing away damp-heat, dissipating blood stasis, detumescence, removing toxic substances.Control stranguria with turbid discharge, hematuria, traumatic injury, acute appendicitis, furuncle Swollen, otitis media.
Cup chrysanthemum: bitter is cool.Heat-clearing and toxic substances removing, anti-inflammation hemostasia, dehumidify diuresis, parasite killing.Cure mainly acute gastroenteritis, heatstroke, bladder Inflammation, urethritis, pharyngolaryngitis, stomatitis, spit blood, epistaxis.
Rhizoma Imperatae: sweet, cold.Return lung, stomach, bladder warp.Cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, urine Blood, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria;Acute nephritis edema.
Caulis Entadae: pungent, tepor.Dredge wind prevailing over dampness, relaxing muscles and tendons and activating QI and blood in the collateral, diuresis, dissipating blood stasis.Control arthralgia chiefly caused by damp pathogen apathetic, bones and muscles pain, Gonorrhea, traumatic injury.
Youth-and-old-age: bitter in the mouth, pungent, cool in nature.Heat clearing away, dampness removing, removing toxic substances.Main hygropyretic dysentery, stranguria, acute mastitis, furuncle and phyma.
XUEJINGCAO: light, cool.Promoting blood flow to regulate menstruation, dissipating blood stasis for subsidence of swelling, diuresis.For menoxenia, leucorrhea, dysuria, traumatic injury Damage, ulcerative carbuncle toxic swelling.
Concha Ostreae: salty, is slightly cold.Return liver, gallbladder, kidney channel.Tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.For insomnia of palpitating with fear, Vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, metrorrhagia and leukorrhagia of passing out semen, acid regurgitation of having a stomachache.
Radix Aconiti Lateralis Preparata: pungent, sweet is the warmmest;Poisonous.GUIXIN, kidney, spleen channel.Recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, by wind-cold damp pathogen.With Collapse in YANG-depletion, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, cold-damp numbness Bitterly.
In medicament composing prescription of the present invention, Caulis et Folium fici Tikouae, Herba Canscorae, Herba Clerodendri fortunati, Herba Galii Teneri, cup chrysanthemum heat-clearing and toxic substances removing, alleviate iodine radiography The toxic and side effects of agent;Rhizoma Imperatae, Caulis Entadae, youth-and-old-age, XUEJINGCAO diuresis are relieved oedema or abdominal distension through diuresis or purgation, and promote that internal water circulates, and accelerate iodine radiography Agent excretes;Concha Ostreae, Radix Aconiti Lateralis Preparata tonifying vital QI, nourish patient's body constitution, improves resistance.
It is an advantage of the current invention that used Chinese medicine meets Pharmacopoeia of People's Republic of China regulation, safety of medicine is reliable.All medicine phases Prevent or alleviate in time during diodone uses or the side effect of generation after use with playing, there is determined curative effect, instant effect, control The features such as more rate is high, have no side effect.
Outcome measure:
1, inclusion criteria
Choose patient 50 example through diodone inspection and these patients appearance clinical side effects the most in various degree, wherein, male 23 examples, women 27 example, 39 years old mean age.
2, Therapeutic Method
Take Chinese medicine preparation of the present invention, oral, every day 2 times, the most each 1 time, each 300ml.
3, curative effect judging standard
Cure: the side effect transference cure occurred during diodone uses or after use.
Take a turn for the better: the side effect symptom occurred during diodone uses or after use has improvement.
Invalid: all diseases are without improving.
4, result
Curing 27 examples, take a turn for the better 22 examples, invalid 1 example, and total effective rate is 98%.
It is exemplified below a model case:
(1) prosperous certain, women, 41 years old, people from Qingdao.Coming my institute and carry out fallopian tube iodine contrast examination, after inspection, patient goes out The most slight heating and vomiting phenomenon, and it is attended by sporadic headache, then treat with Chinese medicine preparation of the present invention, take continuously With two days later, clinical symptoms all disappears, follow-up investigations interior nothing recurrence in a week.
Detailed description of the invention
The present invention will be further described by the following examples.
Embodiment 1:
A kind of Chinese medicine preparation preventing to alleviate diodone side effect, in parts by weight, is prepared from by following raw material of Chinese medicine: Caulis et Folium fici Tikouae 25 parts, Herba Canscorae 10 parts, Herba Clerodendri fortunati 10 parts, Herba Galii Teneri 10 part, glass chrysanthemum 5 parts, Rhizoma Imperatae 25 parts, excessively river Dragon 10 parts, youth-and-old-age 10 parts, XUEJINGCAO 10 parts, Concha Ostreae 10 parts, Radix Aconiti Lateralis Preparata 5 parts.
Embodiment 2:
A kind of Chinese medicine preparation preventing to alleviate diodone side effect, in parts by weight, is prepared from by following raw material of Chinese medicine: Caulis et Folium fici Tikouae 30 parts, Herba Canscorae 15 parts, Herba Clerodendri fortunati 15 parts, Herba Galii Teneri 15 part, glass chrysanthemum 10 parts, Rhizoma Imperatae 30 parts, mistake River dragon 15 parts, youth-and-old-age 15 parts, XUEJINGCAO 15 parts, Concha Ostreae 15 parts, Radix Aconiti Lateralis Preparata 10 parts.
Embodiment 3:
A kind of Chinese medicine preparation preventing to alleviate diodone side effect, in parts by weight, is prepared from by following raw material of Chinese medicine: Caulis et Folium fici Tikouae 28 parts, Herba Canscorae 12 parts, Herba Clerodendri fortunati 12 parts, Herba Galii Teneri 12 part, glass chrysanthemum 8 parts, Rhizoma Imperatae 28 parts, excessively river Dragon 12 parts, youth-and-old-age 12 parts, XUEJINGCAO 12 parts, Concha Ostreae 12 parts, Radix Aconiti Lateralis Preparata 8 parts.
Embodiment 4:
Embodiment 1~3 is prepared in accordance with the following methods: weighs raw material of Chinese medicine according to formula and joins in container, adding water and cover powder Soak 20 minutes, added water no powder 5 centimetres, and decocted with high heat and use slow fire boiling again instead 30 minutes to boiling, take filtrate; Then add water not powder 5 centimetres, with high heat decoct to boiling uses slow fire boiling again instead 20 minutes, then removing slag takes filtrate, Twice filtrate merges.
When taking, each 300ml, one day twice.

Claims (4)

1. the Chinese medicine preparation preventing to alleviate diodone side effect, it is characterised in that in parts by weight, by following Chinese medicine Raw material is prepared from: Caulis et Folium fici Tikouae 25~30 parts, Herba Canscorae 10~15 parts, Herba Clerodendri fortunati 10~15 parts, Herba Galii Teneri 10~15 parts, Cup chrysanthemum 5~10 parts, Rhizoma Imperatae 25~30 parts, Caulis Entadae 10~15 parts, youth-and-old-age 10~15 parts, XUEJINGCAO 10~15 parts, male Oyster 10~15 parts, Radix Aconiti Lateralis Preparata 5~10 parts.
A kind of Chinese medicine preparation preventing to alleviate diodone side effect the most according to claim 1, it is characterised in that according to weight Amount number meter, is prepared from by following raw material of Chinese medicine: Caulis et Folium fici Tikouae 25 parts, Herba Canscorae 10 parts, Herba Clerodendri fortunati 10 parts, Herba Galii Teneri 10 part, glass chrysanthemums 5 parts, Rhizoma Imperatae 25 parts, Caulis Entadae 10 parts, youth-and-old-age 10 parts, XUEJINGCAO 10 parts, Concha Ostreae 10 parts, Radix Aconiti Lateralis Preparata 5 parts.
A kind of Chinese medicine preparation preventing to alleviate diodone side effect the most according to claim 1, it is characterised in that according to weight Amount number meter, is prepared from by following raw material of Chinese medicine: Caulis et Folium fici Tikouae 30 parts, Herba Canscorae 15 parts, Herba Clerodendri fortunati 15 parts, Herba Galii Teneri 15 part, glass chrysanthemums 10 parts, Rhizoma Imperatae 30 parts, Caulis Entadae 15 parts, youth-and-old-age 15 parts, XUEJINGCAO 15 parts, Concha Ostreae 15 parts, Radix Aconiti Lateralis Preparata 10 parts.
A kind of Chinese medicine preparation preventing to alleviate diodone side effect the most according to claim 1, it is characterised in that according to weight Amount number meter, is prepared from by following raw material of Chinese medicine: Caulis et Folium fici Tikouae 28 parts, Herba Canscorae 12 parts, Herba Clerodendri fortunati 12 parts, Herba Galii Teneri 12 part, glass chrysanthemums 8 parts, Rhizoma Imperatae 28 parts, Caulis Entadae 12 parts, youth-and-old-age 12 parts, XUEJINGCAO 12 parts, Concha Ostreae 12 parts, Radix Aconiti Lateralis Preparata 8 parts.
CN201610482201.9A 2016-06-27 2016-06-27 Traditional Chinese medicine preparation for preventing and relieving side effects of iodic contrast agent Withdrawn CN105943920A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106266731A (en) * 2016-10-11 2017-01-04 陈福建 A kind of image department prevents and alleviates the Chinese medicine composition of contrast agent side effect

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105596861A (en) * 2016-02-15 2016-05-25 冯波 Pill used for treating adverse reaction after CT enhancement scanning and preparation method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105596861A (en) * 2016-02-15 2016-05-25 冯波 Pill used for treating adverse reaction after CT enhancement scanning and preparation method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106266731A (en) * 2016-10-11 2017-01-04 陈福建 A kind of image department prevents and alleviates the Chinese medicine composition of contrast agent side effect

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Application publication date: 20160921