CN105943801A - Traditional Chinese medicine composition for reducing blood pressure, as well as preparation method and taking method thereof - Google Patents
Traditional Chinese medicine composition for reducing blood pressure, as well as preparation method and taking method thereof Download PDFInfo
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- CN105943801A CN105943801A CN201610507570.9A CN201610507570A CN105943801A CN 105943801 A CN105943801 A CN 105943801A CN 201610507570 A CN201610507570 A CN 201610507570A CN 105943801 A CN105943801 A CN 105943801A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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Abstract
The invention discloses a traditional Chinese medicine composition for reducing blood pressure, as well as a preparation method and a taking method of traditional Chinese medicine composition. The traditional Chinese medicine composition for reducing the blood pressure is obtained by taking radix notoginseng, endothelium corneum gigeriae galli, rhodiola rosea and aloe as raw materials and mixing according to a certain proportion. When a hypertensive patient is treated, 4 g of the traditional Chinese medicine composition for reducing the blood pressure is orally taken three times a day. The traditional Chinese medicine composition for reducing the blood pressure comprises only four raw material medicines, is simple and convenient to prepare and wide in medicine source and is used for effectively controlling the blood pressure of the hypertensive patient by utilizing the respective efficacies and the mutual matching of all traditional Chinese medicine compositions; a clinical application verifies that the traditional Chinese medicine composition can dredge blood capillaries and is obvious in treatment effect, good in safety, mild in medicine efficacy, free from toxic and side effects and suitable for crowds suffering from high blood pressure.
Description
Technical field
The present invention relates to the field of Chinese medicines, Chinese medicine composition being specifically related to a kind of blood pressure lowering and preparation method thereof and the side of taking
Method.
Background technology
Hypertension be a kind of affect health of people, harm the mankind a kind of commonly encountered diseases.Hypertension refers to circulate tremulous pulse with body
Blood pressure (shrinking pressure and/or diastolic pressure) increases as principal character (contraction pressure >=140 millimetress of mercury, diastolic pressure >=90 milli
Meter mercury column(unit of pressure)), can be with the function of the organs such as the heart, brain, kidney or the clinical syndrome of organic lesion.Hypertension is
Common chronic disease, is also the topmost risk factor of cardiovascular and cerebrovascular disease.
Suffering from hypertension and often can cause the generation of Other diseases, countries in the world medical worker is all developing the high blood for the treatment of
The active drug of pressure, the patent of invention of Application No. 01310448983.0 discloses a kind of Chinese drug-treated group treating blood pressure lowering
Compound, the weight portion of its constitutive material is: Folium Ginkgo 2-4, Petasites tatewakianus Kitam. 5-8, Radix Angelicae Dahuricae 2-4, Herba Oenanthes Javanicae 5-7, Fructus Cucurbitae moschatae
Flower 9-10, Herba Potentillae Chinensis 5-7, Castanea seguinii Dode (Involucrum Castaneae Seguinii) leaf 1-2, Herb Gynostemmae Pentaphylli 3-5, Herba Apocyni veneti 5-7, Zornia diphylla (Linn.) Pers. 8-10, Folium Notoginseng 2-4,
Floral disc of sunflower 3-5, Folium Rehmanniae 1-3, Folium Ilicis 5-7, Flos Sauropi changiani leaf 8-10, Fructus Trichosanthis leaf 2-4, HUDOU flower 3-5, coral
Coral dish 5-7, Radix seu Caulis Schisandrae Sinensis 2-3 and Rhizoma Imperatae 1-3.
The earlier application of Application No. 201510273147.2 discloses the Chinese medicine of a kind of blood pressure lowering, and it is that following weight is joined
The raw material of Chinese medicine composition of ratio: Semen Cassiae 4-6, Flos Chrysanthemi 5-8, Folium Artemisiae Argyi 3-6, Folium Nelumbinis 7-9, Cacumen Platycladi 8-10, summer are withered
Grass 5-8, Folium Ginkgo 4-7, Radix Rehmanniae 6-8, Cortex Lycii 3-5, Herba Alternantherae Versicoloris 4-7, Radix Canavaliae 6-9, Radix desmodiik microphylli 5-8,
Radix et rhizoma lygodii 3-5, Herba eupatorii japonici 6-8, Radix Dodonaeae Viscosae 7-9,
The earlier application of Application No. 201510241559.8 discloses the Chinese medicine formula of a kind of logical blood vessel blood pressure lowering, its bag
Containing following components: Radix Salviae Miltiorrhizae 20～25 parts, Radix Notoginseng 10～15 parts, Radix Angelicae Sinensis 10～15 parts, Hirudo 10～15 parts, Rhizoma Chuanxiong
10～15 parts, the Radix Astragali 10～15 parts, Fructus Liquidambaris 5～10 parts, the Rhizoma Atractylodis Macrocephalae 10～15 parts, Semen Vaccariae 10-15 part, hook
Rattan 5-10 part.
The earlier application of Application No. 201510935340.8 discloses the Chinese medicine composition of a kind of blood pressure lowering of invigorating blood circulation, and it comprises
Following components: Herba Apocyni veneti 20～25 parts, Radix Notoginseng 10～15 parts, Flos puerariae lobatae 10～15 parts, Hirudo 10～15 parts, Rhizoma Chuanxiong
10～15 parts, clear and decided sub 10～15 parts, Fructus Liquidambaris 5～10 parts, the Rhizoma Atractylodis Macrocephalae 10～15 parts, Semen Vaccariae 10-15 part,
Ramulus Uncariae Cum Uncis 5-10 part.
The patent of invention of Application No. 201510081343.X discloses a kind of Chinese medicine glue treating hypertension, hyperlipidemia
Capsule.Content in capsule includes: Chinese medicine extract 40-45 part, MEIHUA BINGPIAN 5-7 part, Rhizoma Acori Graminei 8-10 part,
Bulbus Lilii 8-12 part, Herba Alii fistulosi 4-5 part, peony seed oil 20 parts, Fructus Crataegi dry slice 8-10 part, Semen Cassiae 8-10 part, Macrocystis pyrifera (L.) Ag.
4-8 part, big Herba Swertiae heteranthae 5-7 part, Radix Polygalae fallacis 5-7 part, Radix Berberidis anhweiensis leaf 4-8 part, Bulbus Allii Macrostemonis oil 3-5 part.
Although as it has been described above, the antihypertensive species of Clinical practice is a lot of at present, but ingredient is of a great variety,
Complicated component, weak effect during medication, side effect is more, does not play good therapeutic effect.Hyperpietic needs
Want more effective therapeutic scheme.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art, it is provided that a kind of effect substantially, few side effects be used for drop
Chinese medicine composition of blood pressure and preparation method thereof and instructions of taking.
For achieving the above object, the present invention adopts the following technical scheme that
A kind of Chinese medicine composition of blood pressure lowering, it mixes by the component of following weight portion:
Preferably, described Chinese medicine composition is mixed by Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Rhodiolae and Aloe equal proportion, and it is controlled
Therapeutic effect is the most notable.
The preparation method of the Chinese medicine composition of blood pressure lowering of the present invention, is by Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Rhodiolae and reed
Luxuriant growth grinds, mix homogeneously, obtain the Chinese medicine composition of blood pressure lowering.Patient, when taking, is administered orally described blood pressure lowering
Chinese medicine composition, three times a day, each 4g.
Radix Notoginseng has the effects such as lowering blood pressure and blood fat, and Radix Notoginseng is rich in arasaponin, Radix Notoginseng polysaccharide, dencichine, flavone
Effective ingredient, has the effects such as hemostasis, blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain, blood fat reducing, blood sugar lowering.Endothelium Corneum Gigeriae Galli has fall blood
The effects such as sugar.Effective ingredient contained by Radix Rhodiolae has heart tonifying calmness, regulation metabolism, nervous system regulation and interior point
Secrete system bidirectional regulation blood glucose, the effect of blood pressure, be used for treating cerebrovascular disease etc..Aloe has the work that heart tonifying is invigorated blood circulation
With.The present invention uses above technical scheme, with Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Rhodiolae and Aloe as raw material, by a certain percentage
Mixing (preferably equal proportion mixing) obtains the Chinese medicine composition of blood pressure lowering.The Altace Ramipril composition of the present invention is only
4 taste crude drug, its preparation is easy, medicine source is wide, utilizes the respective effect of each Chinese medicine ingredients, and cooperates, to height
Blood pressure patient carries out effective control of blood pressure, verifies by clinic application, and it can dredge blood capillary, and therapeutic effect shows
Write, safety is good, mild in medicine property and, toxic and side effects does not occurs, it is adaptable to suffer from the crowd of hypertension.
Detailed description of the invention
A kind of Chinese medicine composition of blood pressure lowering, it mixes by the component of following weight portion:
Preferably, described Chinese medicine composition is mixed by Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Rhodiolae and Aloe equal proportion, and it is controlled
Therapeutic effect is the most notable.
The preparation method of the Chinese medicine composition of blood pressure lowering of the present invention, is by Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Rhodiolae and reed
Luxuriant growth grinds, mix homogeneously, obtain the Chinese medicine composition of blood pressure lowering.Patient, when taking, is administered orally described blood pressure lowering
Chinese medicine composition, three times a day, each 4g.
Below in conjunction with specific embodiment, the present invention is further detailed explanation:
Embodiment 1
A kind of Chinese medicine composition of blood pressure lowering, by weight, its by Radix Notoginseng 1 part, Endothelium Corneum Gigeriae Galli 1 part, Radix Rhodiolae 1 part and
Aloe 1 part (i.e. equal proportion) mixes.
By Chinese medicine composition (spirit of named compound blood pressure reducing) the controlling for hyperpietic of the blood pressure lowering of the present embodiment 1
Treat, obtain obvious curative effect, be embodied as follows:
Treatment target: hyperpietic's (30 example)
Therapeutic Method: all patients all take the compound blood pressure reducing spirit of embodiment 1, by compound blood pressure reducing spirit grinds, patient
Oral administered compound verticil, three times a day, each 4g.
Therapeutic effect: 30 example patients are after medication one week, and hypertension symptom all take a favorable turn, after medication 1-3 month,
The blood pressure of all patients all tends to normal, and cure rate is the highest, and does not find obvious side reaction during treatment.
Model case 1: patient Lin, man, 67 years old, suffers from hypertension 5 year, takes the Chinese drug-treated group of the present embodiment 1
Compound, three times a day, each 4g.After taking three months, patients' blood recovers normal.Then proceed to take one month
To consolidate curative effect.
Model case 2: patient tight certain, female, 71 years old, suffer from hypertension, cerebral infarction half a year, left side upper and lower extremities is unable,
Inconvenient activity, blood pressure 180/102mmHg, takes the Chinese medicine composition of the present embodiment 1, three times a day, each 4g.
, after taking one month, blood pressure inspection is decreased obviously, and continues to take after two months, and inspection blood pressure is 125/80mmHg.
Other patient, such as Lin, river, Chen Mouqing, Chen is precious, all has similar therapeutic effect.
The present invention uses the formula of embodiment 1, has also carried out zoopery, and research compound blood pressure reducing spirit is to hypertension mouse
Blood pressure and the impact of index of correlation thereof, be embodied as follows:
One, experiment purpose: research compound blood pressure reducing spirit to hypertension mouse blood pressure and index of correlation such as serum K, Na,
Ca, angiotensin, aldosterone, the impact of catecholamine.
Two, materials and methods:
Animal: modeling hypertension is grown up ICR mice 80, normal adult ICR mice 20, male and female half and half.
Medicine: compound blood pressure reducing spirit (uses the formula of embodiment 1, it may be assumed that Radix Notoginseng 1 part；Endothelium Corneum Gigeriae Galli 1 part；Radix Rhodiolae 1
Part；Aloe 1 part, by weight for 1:1:1:1, grinds, mix homogeneously is standby.)
Instrument: BP-2010A rat-tail measuring cell
Animal is grouped: modeling hypertension is grown up ICR mice 80, (high salt (80mg/mL NaCl solution) cold shock method,
20d continuously, forms mice hypertension model)；Experiment mice is randomly divided into 4 groups (n=20, male and female half and half) by body weight:
1, medicine blank group (0mg/kg),
2, low-dose drugs treatment group (60mg/kg),
3, middle dose medication regimen group (120mg/kg),
4, high dose medicament treatment group (240mg/kg)；
5, normotensive controls group.
Wherein, dosage is described as follows, and such as, low-dose drugs treatment group, 60mg/kg refers to the little of every kg body weight
Mus, dosage is 60mg.
Method: each group Mouse feeder temperature 22 DEG C, animal can freely drink water and take food, every day gastric infusion high pressure group,
Normotensive controls group is to placebo (feedstuff grinds).After three months, measuring mice blood pressure, every measurement takes for three times
Meansigma methods.After having surveyed blood pressure, eyeball takes blood, separates serum, is used for detecting K, Na, Ca, angiotensin, aldehyde solid
The index such as ketone, catecholamine.
Three, experimental result:
(1) four kinds of dosage treatment levels of compound blood pressure reducing spirit are variant on the impact of mice blood pressure, and blood pressure is with compound recipe
The increase of verticil dosage and decline, compound blood pressure reducing spirit dosage group and blank group difference statistically significant (p < 0.05)；
No significant difference (p ＞ 0.05) between basic, normal, high dosage group.Compound blood pressure reducing spirit high, medium and low treatment group with
Difference of blood pressure not statistically significant (p ＞ 0.05) between normal group.Specifically it is shown in Table 1.
The impact (mmHg) on mice blood pressure of the table 1 compound blood pressure reducing spirit various dose level
The level of (2) five groups of mice serum Na is essentially identical, no significant difference (p ＞ 0.05) between five groups,
Specifically it is shown in Table 2.
The result (mmol/L) of 2 five groups of mice serum Na of table
The level of (3) five groups of mice serum K is essentially identical, no significant difference (p ＞ 0.05) between five groups, tool
Body is shown in Table 3.
The result (mmol/L) of 3 five groups of mice serum K of table
The level of (4) five groups of mice serum Ca is essentially identical, no significant difference (p ＞ 0.05) between five groups,
Specifically it is shown in Table 4.
The result (mmol/L) of 4 five groups of mice serum Ca of table
The level of (5) five groups of mice serum angiotensin is essentially identical, no significant difference (p between five groups
＞ 0.05), specifically it is shown in Table 5.
The result (ng/mL) of 5 five groups of mice serum angiotensin of table
The level of (6) five groups of mice serum aldosterone is essentially identical, no significant difference (p ＞ between five groups
0.05) 6, specifically it are shown in Table.
The result (pg/mL) of 6 five groups of mice serum aldosterone of table
The level of (7) five groups of mice serum catecholamines is essentially identical, no significant difference (p ＞ between five groups
0.05) 7, specifically it are shown in Table.
The result of 7 five groups of mice serum catecholamines of table
Four, conclusion
Compound blood pressure reducing spirit is to have statistical significance to the hypotensive effect of hypertension mouse blood pressure, to hypertension Serum markers
Impact is little, illustrates that compound blood pressure reducing spirit can make the mice blood pressure of hypertension return to normal level.
Embodiment 2
A kind of Chinese medicine composition of blood pressure lowering, it mixes by the component of following weight portion:
By Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Rhodiolae and Aloe grinds, mix homogeneously, obtain the Chinese medicine composition (life of blood pressure lowering
Entitled compound blood pressure reducing spirit).Patient is when treatment, and oral described compound blood pressure reducing is clever, three times a day, and each 4g.
Compound blood pressure reducing spirit by the present embodiment 2 is used for the treatment of hyperpietic, obtains obvious curative effect,
Treatment target: hyperpietic's (16 example)
Therapeutic Method: all patients all take the compound blood pressure reducing spirit of embodiment 2, three times a day, each 4g.
Therapeutic effect: 16 example patients are after medication one week, and hypertension symptom all take a favorable turn, after medication 1-2 month,
The patients' blood of 80% all tends to normal, and does not find obvious side reaction during treatment.After medication 3 months,
All patients' blood all recover normal.
Embodiment 3
A kind of Chinese medicine composition of blood pressure lowering, it mixes by the component of following weight portion:
By Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Rhodiolae and Aloe grinds, mix homogeneously, obtain the Chinese medicine composition (life of blood pressure lowering
Entitled compound blood pressure reducing spirit).Patient is when treatment, and oral described compound blood pressure reducing is clever, three times a day, and each 4g.
Compound blood pressure reducing spirit by the present embodiment 3 is used for the treatment of hyperpietic, obtains obvious curative effect,
Treatment target: hyperpietic's (20 example)
Therapeutic Method: all patients all take the compound blood pressure reducing spirit of embodiment 3, three times a day, each 4g.
Therapeutic effect: 20 example patients are after medication 4 months, and blood pressure recovers normal substantially.Wherein 3 patients are in medication
After one week, blood pressure the most substantially reduces, and after continuing medication one month, blood pressure has recovered normal value.
Claims (4)
1. the Chinese medicine composition of a blood pressure lowering, it is characterised in that: it is mixed by the component of following weight portion:
Radix Notoginseng 1 ~ 1.2 part；
Endothelium Corneum Gigeriae Galli 1 ~ 1.2 part；
Radix Rhodiolae 1 ~ 1.2 part；
Aloe 1 ~ 1.2 part.
The Chinese medicine composition of a kind of blood pressure lowering the most according to claim 1, it is characterised in that: described Chinese medicine composition is mixed by Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Rhodiolae and Aloe equal proportion.
3. the preparation method of the Chinese medicine composition of a blood pressure lowering as claimed in claim 1 or 2, it is characterised in that: by Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Rhodiolae and Aloe grinds, mix homogeneously, obtain the Chinese medicine composition of blood pressure lowering.
4. the instructions of taking of the Chinese medicine composition of a blood pressure lowering as claimed in claim 3, it is characterised in that: the Chinese medicine composition of oral described blood pressure lowering, three times a day, each 4g.
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| CN201610507570.9A CN105943801A (en) | 2016-06-30 | 2016-06-30 | Traditional Chinese medicine composition for reducing blood pressure, as well as preparation method and taking method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147549A (en) * | 2014-08-28 | 2014-11-19 | 范武昌 | Medicine for treating hypertension |
| CN105169197A (en) * | 2015-09-03 | 2015-12-23 | 哈尔滨泉兴科技有限公司 | Traditional Chinese medicine for efficiently and fast lowering blood pressure |
| CN105707863A (en) * | 2016-03-10 | 2016-06-29 | 劲膳美生物科技股份有限公司 | Blood fat-reducing medical science formula food |
-
2016
- 2016-06-30 CN CN201610507570.9A patent/CN105943801A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147549A (en) * | 2014-08-28 | 2014-11-19 | 范武昌 | Medicine for treating hypertension |
| CN105169197A (en) * | 2015-09-03 | 2015-12-23 | 哈尔滨泉兴科技有限公司 | Traditional Chinese medicine for efficiently and fast lowering blood pressure |
| CN105707863A (en) * | 2016-03-10 | 2016-06-29 | 劲膳美生物科技股份有限公司 | Blood fat-reducing medical science formula food |
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