CN105943799A - Compound preparation for treating contact dermatitis and preparation method thereof - Google Patents

Compound preparation for treating contact dermatitis and preparation method thereof Download PDF

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Publication number
CN105943799A
CN105943799A CN201610492052.4A CN201610492052A CN105943799A CN 105943799 A CN105943799 A CN 105943799A CN 201610492052 A CN201610492052 A CN 201610492052A CN 105943799 A CN105943799 A CN 105943799A
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parts
preparation
compound preparation
cortex
aloe
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李肖
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Priority to CN201610492052.4A priority Critical patent/CN105943799A/en
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Priority to PCT/CN2016/108564 priority patent/WO2018000727A1/en
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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    • A61K36/13—Coniferophyta (gymnosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The invention discloses a compound preparation for treating contact dermatitis. The compound preparation is prepared from the following main raw materials in parts by weight: 5-10 parts of Cortex dictamni, 4-9 parts of radix sophorae flavescentis, 10-20 parts of propolis, 10-20 parts of Coptis chinensis, 5-15 parts of aloe, 7-13 parts of lotus pollen, 4-10 parts of cortex acanthopanacis, 5-10 parts of pericarpium citri reticulatae viride, 3-7 parts of honeysuckle, 2-4 parts of indigo naturalis, 5-10 parts of folium mori, 3-8 parts of golden larch bark and 5-15 parts of rosehip oil. Medicinal materials and medicinal herb resources of the compound preparation are easy to get and low in cost; the selected medicinal materials are mostly mild in medicine property, and cannot increase the burden of economy and body for users after long-term use.

Description

A kind of compound preparation treating contact dermatitis and preparation method
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of compound preparation treating contact dermatitis and preparation side Method.
Background technology
Contact dermatitis be skin or mucosa single or multiple contact exogenous material after, contact site even beyond The inflammatory reaction that position occurs.Show as erythema, swelling, pimple, vesicle even bulla.
The cause of disease: constitutional can be divided into stimulate and allergy two kinds.1. PICD contactant is to skin Skin has the strongest zest, dermatitis, referred to as constitutional all can be occurred to stimulate after anyone contact.Constitutional stimulation is divided into two kinds, A kind of zest is very strong, morbidity in the short time after contact；Another kind is more weak, and long period contact sequela, such as soap, You Jirong Agent etc..2. allergic contact dermatitis contactant is substantially non-stimulated, after a few peoples contact this material sensitization, then This material of secondary contact, through 12～48 hours contact site and near generation dermatitis.The material of contact dermatitis can be caused very Many, mainly there are animality, vegetalitas and chemical three kinds.
, owing to contactant, the way of contact and individual reaction are different, there is the form of dermatitis, model in performance: typically without specificity Enclose and the order of severity also differs.During mild, local is in erythema, light red to cerise, slightly edema, or has the big pimple of needle point close Collection, during serious symptom, erythema swelling is obvious, has most pimple, vesicle on this basis, bulla can occur during intense inflammation.Vesicle is broken Split, have erosion, sepage and incrustation.As for strong primary stimulus, Epidermal necrosis can be made to come off, even deep and corium occurs to burst Infections.When dermatitis betides tissue looseness position, as eyelid, lip, foreskin, scrotum etc. then swelling is obvious, in localized edema And without clear and definite edge, glowing skin, superficial makings disappears.Position and the scope of dermatitis are consistent with contactant contact site, border Boundary is the distinctest, but if contactant is gas, dust, then dermatitis is diffusivity and without certain distinct boundary, but mostly occurs Health exposure portion.Subjective symptoms has mostly itches and burn feeling or distending pain sense, and minority several cases can have general reaction, as sent out Heat, fear of cold, have a headache, feel sick.The course of disease has self limiting, after the general removal cause of disease, processes proper, within 1～2 week, can fully recover.Repeatedly connect Touch or deal with improperly, subacute or chronic dermatitis can be transferred to, in bronzing lichenification or eczema sample change.Zest contacts Property dermatitis acute stage clinically, can behave as erythema, vesicle, oozes out.Subacute, chronic show erythema, coarse, desquamation, chap Split.Character according to thigmic stimulus thing and length time of contact, can behave as Acute irritation test dermatitis, retardance acute clinically Irritant dermatitis, irritative response, cumulative bad irritant dermatitis, pustular irritant dermatitis, mechanical irritation induction dermatitis etc..
In the Chinese medicine of existing treatment contact dermatitis, Authorization Notice No. CN 103110747 B(application number 201210529338.7) patent documentation discloses a kind of Chinese medicine for outer use treating contact dermatitis, it is characterised in that each The weight of raw material of Chinese medicine consists of: Radix Gentianae 3 parts, Cortex Dictamni 3 parts, Fructus Forsythiae 3 parts, Herba Taraxaci 2 parts, Radix Et Rhizoma Rhei 2 parts, Fructus Gardeniae 4 Part, Scorpio 2 parts, Borneolum Syntheticum 1 part, Flos Genkwa 1 part and Radix Phytolaccae 2 parts.Authorization Notice No. CN 103006877 B(application number 201110250108.2) patent discloses a kind of pharmaceutical composition treating contact dermatitis, it is characterized in that: with gram be Unit, Rhizoma Coptidis 10, Radix Scutellariae 20, Radix Bupleuri 15, Cortex Phellodendri 10, Radix Et Rhizoma Rhei 10, Fructus Gardeniae 20, Cortex Dictamni 15, Rhizoma Chuanxiong 15, Fructus Forsythiae 15, Radix Scrophulariae 20, Radix Salviae Miltiorrhizae 15, the Radix Astragali 30, Fructus Aurantii Immaturus 15, Radix Glycyrrhizae 15, the Radix Rehmanniae 20, the Rhizoma Atractylodis Macrocephalae 20, Lignum Sappan 15, Carapax Trionycis 30, Herba Leonuri 30, Periostracum Cicadae 20, the Radix Paeoniae Alba 20, Herba Ephedrae 10, Polyporus 10, Poria 15.
As can be seen here, Chinese medicine occupies very important status in terms for the treatment of contact dermatitis, but in patent documentation, group Fang Danyi, therapeutic domain is single, and effect is unsatisfactory, adds the psychological burden of the wounded, and medical expense is high, add The financial burden of patient.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide the compound preparation for the treatment of contact dermatitis, Medical material medicine source of the present invention is easy to get, and with low cost, selected medical material mostly is the thing of mild in medicine property sum, and life-time service also will not increase to user Add the burden on economy and health.
Another object of the present invention is just to provide the preparation method of above-mentioned compound preparation.
The technical scheme is that
The compound preparation for the treatment of contact dermatitis, takes off and states the primary raw material of weight proportion and be prepared from: Cortex Dictamni 5-10 part, bitter Ginseng 4-9 part, propolis 10-20 part, Rhizoma Coptidis 10-20 part, Aloe 5-15 part, Flos Nelumbinis pollen 7-13 part, Cortex Acanthopancis 4-10 part, Pericarpium Citri Reticulatae Viride 5- 10 parts, Flos Lonicerae 3-7 part, Indigo Naturalis 2-4 part, Folium Mori 5-10 part, Cortex Pseudolaricis 3-8 part, Rosehips oil 5-15 part.
Treatment contact dermatitis compound preparation, preferred scheme is, take off state weight proportion primary raw material preparation and Become: Cortex Dictamni 6-9 part, Radix Sophorae Flavescentis 5-8 part, propolis 13-18 part, Rhizoma Coptidis 13-18 part, Aloe 8-13 part, Flos Nelumbinis pollen 9-11 part, five Cortex Acanthopanacis Radicis 6-8 part, Pericarpium Citri Reticulatae Viride 6-9 part, Flos Lonicerae 4-6 part, Indigo Naturalis 2.5-3.5 part, Folium Mori 6-9 part, Cortex Pseudolaricis 4-7 part, Rosehips oil 8-13 part.
The compound preparation for the treatment of contact dermatitis, the scheme being more highly preferred to is, takes off the primary raw material system stating weight proportion For forming: Cortex Dictamni 7.5 parts, Radix Sophorae Flavescentis 6.5 parts, propolis 15 parts, Rhizoma Coptidis 15 parts, Aloe 10 parts, Flos Nelumbinis pollen 10 parts, Cortex Acanthopancis 7 Part, 7.5 parts of Pericarpium Citri Reticulatae Viride, Flos Lonicerae 5 parts, Indigo Naturalis 3 parts, 8 parts of Folium Mori, Cortex Pseudolaricis 5.5 parts, Rosehips oil 10 parts.
The preparation method of above-mentioned compound preparation, step is as follows:
(1) Aloe brush is cleaned down, remove thorn, then skin upper and lower for Folium Aloe is also removed, rinse gel with water, will Gel is put in juice extractor 2-6 minute (preferably 4 minutes) of squeezing, filters off residue, obtains Aloe juice stand-by；
(2) propolis, Flos Nelumbinis pollen and Indigo Naturalis are gone the removal of impurity, tight with fresh Folium Nelumbinis parcel, it is placed on steaming tray and steams 20-40 Minute, take out dry in the air cool, by step (1) gained Aloe juice and Rosehips oil together with the propolis steamed, Flos Nelumbinis pollen and Indigo Naturalis Mixing, constantly stir with waddy, the high temperature sterilize 10-30 second, bottle medicine is smeared in external；
(3) repeatedly stir-frying Cortex Dictamni, Rhizoma Coptidis and Cortex Acanthopancis to crisp, grinding to form smalls, to cross 80-120 mesh sieve stand-by；
(4) Radix Sophorae Flavescentis, Flos Lonicerae, Folium Mori and Cortex Pseudolaricis are together placed in transparent container, add the warm water of 30-40 DEG C, clean Totally, chopping, with yellow wine, the crude drug of chopping to be mixed thoroughly, be placed in tinfoil, upper baking box is baked 3-7 minute, takes out, and the 10-30 that dries in the air divides Clock, is laid on clean tile, and little fire dries 3-8 minute slowly, dries in the air to crisp, grinds to form smalls stand-by；
(5) being placed in marmite by Pericarpium Citri Reticulatae Viride, add the clear water of Pericarpium Citri Reticulatae Viride weight 4-10 times, big fire is boiled, and turns slow fire boiling 18-28 minute (preferably turning slow fire boiling 23 minutes), filters, and filtrate is stand-by；
(6) step (3) and (4) gained smalls are mixed, add in step (5) gained filtrate, be placed on electromagnetic oven heating While stirring, after mixing thoroughly completely, add dextrin, after dextrin melts completely, obtain mixed liquor cross 180-220 mesh drainage screen, filtrate It it is oral liquid medicine.
The preparation method of above-mentioned compound preparation, step (2) is tight with fresh Folium Nelumbinis parcel, is placed on steaming tray and steams 25- 35 minutes (preferably, tight with fresh Folium Nelumbinis parcel, to be placed on steaming tray and steam 30 minutes).
The preparation method of above-mentioned compound preparation, step (3) grinds to form smalls and crosses stand-by (preferably, the grinding of 90-110 mesh sieve Smalls is become to cross 100 mesh sieves stand-by).
The preparation method of above-mentioned compound preparation, the consumption of step (4) yellow wine is to mix 0.3-0.7 times of crude drug (preferably , the consumption of yellow wine is 0.4-0.6 times of mixing crude drug, and more preferably, the consumption of yellow wine is the 0.5 of mixing crude drug Times).
The preparation method of above-mentioned compound preparation, step (4) is dried in the air 15-25 minute, is laid on clean tile, and little fire dries slowly 4-7 minute (preferably, dry in the air 20 minutes, be laid on clean tile, little fire dries 5 minutes slowly).
The preparation method of above-mentioned compound preparation, step (5) adds the clear water of Pericarpium Citri Reticulatae Viride weight 6-8 times and (preferably, adds Pericarpium Citri Reticulatae Viride The clear water that weight is 7 times).
The preparation method of above-mentioned compound preparation, step (6) obtains mixed liquor after dextrin melts completely and crosses the filtration of 190-210 mesh Net (preferably obtains mixed liquor after dextrin melts completely and crosses 200 mesh drainage screens).
The pharmacological effect of each crude drug is respectively as follows:
Cortex Dictamni: Cortex Dictamni is the skin of Rutaceae herbaceos perennial dittany, bitter, cold.Return lung meridian.There is heat clearing and damp drying, removing toxic substances Antipruritic effect.In the form of a roll, Lei Baiyou side, surface root, section stratiform little Bai is brilliant, heat-clearing and toxic substances removing wind-damp dispelling for Cortex Dictamni.
Radix Sophorae Flavescentis: for the dry root of leguminous plant Radix Sophorae Flavescentis, excavate in spring, season in autumn two, removing root head and little supporting root, cleaning, drying, Or take advantage of fresh slices, it is dried.It is bitter, cold.There are heat clearing and damp drying, parasite killing, the merit of diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, red in vain Leukorrhagia, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.
Propolis: propolis is the resin that Apis gathers from plant spore or trunk, be mixed into palatine gland on it, wax gland point A kind of colloidal solid thing with aromatic odor that secretion processes.It is that the repairing Nidus Vespaes such as Apidae animal apis cerana are divided The yellowish-brown secreted or the stickum of pitchy, can be used as medicine.Its property is put down, bitter in the mouth, pungent, micro-sweet, has skin moistening granulation promoting, anti-inflammatory analgetic The diseases such as effect, can treat gastric ulcer, oral ulcer, burn and scald, skin splitting pain, radioprotective.
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomit acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, heart-fire High Sheng, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache is quenched one's thirst, carbuncle furuncle；External treatment eczema, eczema, auditory meatus is suppurated.Rhizoma Coptidis (processed with wine) The kind clear part of the body cavity above the diaphragm housing the heart and lungs is burning hot.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tying mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted. Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomit acid regurgitation.
Aloe: effect: pathogenic fire purging；Removing toxic substances；Blood stasis dispelling；Parasite killing.Argument is red；Constipation；Nebulousurine；Hematuria；Pediatric epilepsy scared；Infantile malnutrition；Burn Scald；Women's amenorrhea；Hemorrhoid；Scabies；Carbuncle furuncle and phyma poison；Traumatic injury.Bactericidal action, antiinflammatory action, moistening beautification function, stomach invigorating Under let out effect, the heart tonifying effect of invigorating blood circulation, immunity and regeneration, immunity and antitumor action, Detoxication, anti-aging effects, town Bitterly, sedation, anti-sunlight function.
Flos Nelumbinis pollen: looks improving and the skin nourishing, slow down aging warp, controlling nocturnal emission with astringent drugs is only lost；Tranquilizing by nourishing the heart, hemostasis with astringents, controlling nocturnal emission with astringent drugs benefit essence, bowel relieving Toxin expelling, beauty and skin care, clear nevus despeckle, is the good merchantable brand of maintenance nourishing beautifying nourishing, and applicable women takes, and the most specifically has very well Antiobesity action.
Cortex Acanthopancis: acrid in the mouth, hardship, warm in nature.Gui Jing: liver, kidney channel.Function: have wind-damp dispelling, liver and kidney tonifying, bone and muscle strengthening, diuretic The effect of detumescence.Cure mainly: for Bi condition, muscles and bones flaccidity is soft, children's's walking retardation in children, and body void is weak, edema, tinea pedis.
Pericarpium Citri Reticulatae Viride: bitter in the mouth, pungent, warm in nature.Gui Jing: return liver, gallbladder, stomach warp.Function: have soothing the liver dispelling the stagnated QI, effect that removing food stagnancyization is stagnant.Main Control: for distending pain in the chest and hypochondrium, hernia pain, nodules of the breast, acute mastitis, stagnation of QI due to dyspepsia, abdominal distention.
Flos Lonicerae: Flos Lonicerae is cold in nature, sweet in the mouth, enter lung, the heart, stomach warp, there is heat-clearing and toxic substances removing, antiinflammatory, effect of qi-restoratives treatment wind, Cure mainly disease under distension, epidemic febrile disease heating, the disease such as pyretic toxicity carbuncle and ulcer and tumor.It makees thirsty, hyperhidrosis unhappiness, intestinal for dizzy dizziness, xerostomia Inflammation, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, The disease such as parotitis, suppurative tonsillitis all has certain curative effect.
Indigo Naturalis: have another name called Concha Meretricis Seu Cyclinae powder, indigo-blue flower, for Acanthaceae Acanthaceous indigo platymiscium Acanthaceous indigo, Polygonaceae arsesmart polygonum tinctorium ait., pulse family wood Blue platymiscium Folium et Caulis Indigoferae Tinctoriae, the leaf of Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort. or the processed prepared dried powder of stem and leaf or agglomerate.The property of medicine: This product is navy blue powder, and body is light, easily flies upward, and micro-have a careless stink smell, and salty in the mouth is cold in nature.Composition: its main component has indirubin, Indigo.Finding according to modern pharmacological research, this medical instrument has antitumor, anti-inflammatory and antalgic, antiulcer, antibacterial, clearing away heat and cooling blood, removing toxic substances The symptoms such as effect, for temperature poison macule, laryngopharynx swelling and pain, spits blood, epistaxis, spitting of blood.
Folium Mori: these product are evacuated the most clearly, external enwergy dispelling wind and heat pathogens, interior can lung heat clearing, suppressing the hyperactive liver, improving eyesight, the conventional anemopyretic cold, scorching controlled Impairing the lung, excessive rising of liver-YANG and wind heat or liver-fire conjunctival congestion flu, dryness-heat impairing the lung, excessive rising of liver-YANG and wind heat or liver-fire conjunctival congestion and swelling pain, liver-yin The eyes of deficiency is dim-sighted.Additionally, again can cooling blood for hemostasis.
Cortex Pseudolaricis: have another name called arhat Cortex Pini Massonianae, wattle skin, pseudolaricis,cortex, for Pinaceae Pseudolarix plant golden larch root bark and Near root bark.The property of medicine: root bark is irregular strip, distorts and slightly rolls up, and not of uniform size, matter is tough, feeble QI, acrid in the mouth, hardship, property Temperature.Composition: root bark contains pseudolaric acid B, betulic acid, myricetin, amaron alcohol A and B etc..Send out according to modern pharmacological research Existing, this medical instrument has antifungal, anticancer, effect of expelling wind and removing dampness, killing parasites for relieving itching, for eczema, neurodermatitis.
Rosehips oil: daily effect: deep layer Glycerin, offer nutrient, makes skin soft, soft, moistening, prevents ultraviolet pair Skin damages, skin whitening；Increase vigor of skin tissue, keep skin high resilience, shrink coarse pore, can make dry and cracked It is naturally honorable that skin recovers it；Special treatment: new and old cicatrix after improving and eliminating wound, as comedo, skin sore stay concavo-convex Hole, tan severely, cicatrix that scar of burning, Post operation stay.Eliminate the blackout after changing skin and red and swollen phenomenon.Prevent and eliminate striae gravidarum； Preventing pigementation, spot fading, the black speck that disappears, freckle, senile plaque, chloasma, eye-care can eliminate black eye, lema fat Grain, granulation, verruca plana.
1, compound preparation of the present invention " focuses on entirety ", both can treat contact dermatitis, and can treat again aphtha, eczema, Herba Urticae Cannabinae Rash, herpes zoster etc., this compound preparation is based entirely on Chinese medicine principle and is prepared from, more safe and reliable, secondary without any poison Effect, to matrix without any stimulation.
2, medical material compatibility selected by compound preparation of the present invention is suitable, uses modern advanced pharmaceutical technology to make, evident in efficacy, Safe without toxic side effect, treating both the principal and secondary aspects of a disease, should be widely promoted application.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited by this.
Embodiment 1 treats the compound preparation of contact dermatitis, takes off and states the primary raw material of weight proportion and be prepared from (every part Take 10g): Cortex Dictamni 5 parts, Radix Sophorae Flavescentis 4 parts, propolis 10 parts, Rhizoma Coptidis 10 parts, Aloe 5 parts, Flos Nelumbinis pollen 7 parts, Cortex Acanthopancis 4 parts, Pericarpium Citri Reticulatae Viride 5 parts, Flos Lonicerae 3 parts, Indigo Naturalis 2 parts, 5 parts of Folium Mori, Cortex Pseudolaricis 3 parts, Rosehips oil 5 parts.
The preparation method of above-mentioned compound preparation, step is as follows:
(1) Aloe brush is cleaned down, remove thorn, then skin upper and lower for Folium Aloe is also removed, rinse gel with water, will Gel is put in juice extractor squeezing 2 minutes, filters off residue, obtains Aloe juice stand-by；
(2) propolis, Flos Nelumbinis pollen and Indigo Naturalis are gone the removal of impurity, tight with fresh Folium Nelumbinis parcel, it is placed on steaming tray and steams 20 points Clock, taking-up is dried in the air cool, and step (1) gained Aloe juice is together mixed with the propolis steamed, Flos Nelumbinis pollen and Indigo Naturalis with Rosehips oil Close, constantly stir with waddy, high temperature sterilize 10 seconds, bottle medicine is smeared in external；
(3) repeatedly stir-frying Cortex Dictamni, Rhizoma Coptidis and Cortex Acanthopancis to crisp, grinding to form smalls, to cross 80 mesh sieves stand-by；
(4) Radix Sophorae Flavescentis, Flos Lonicerae, Folium Mori and Cortex Pseudolaricis are together placed in transparent container, add the warm water of 30 DEG C, clean dry Only, chopping, with yellow wine, the crude drug of chopping to be mixed thoroughly, be placed in tinfoil, upper baking box is baked 3 minutes, takes out, dries in the air 10 minutes, lays On clean tile, little fire dries 3 minutes slowly, dries in the air to crisp, grinds to form smalls stand-by；
(5) being placed in marmite by Pericarpium Citri Reticulatae Viride, add the clear water of Pericarpium Citri Reticulatae Viride weight 4 times, big fire is boiled, and turns slow fire boiling 18 minutes, filters, Filtrate is stand-by；
(6) step (3) and (4) gained smalls are mixed, add in step (5) gained filtrate, be placed on electromagnetic oven heating While stirring, adding dextrin after mixing thoroughly completely, obtain mixed liquor and cross 180 mesh drainage screens after dextrin melts completely, filtrate is Oral liquid medicine.
Model case one: Liu XX, man, 38 years old, Jinan, Shandong Province people from Jiyang, after cervical spondylosis Dressed plaster, local substantially scabies Itching, examine my institute, look into, cervical region is shown in there is intensive pimple, and local skin flushing, companion's swelling, skin Lightening, superficial makings disappear, Examining as contact dermatitis, doctor advised uses and coordinates the compound preparation taking gained of the present invention treatment contact dermatitis.
Using the present embodiment 1 gained external to smear medicine and oral liquid medicine is taken in cooperation, after 1 day, malaise symptoms substantially alleviates, Being continuing with 2 days, the place of local skin flushing, color is thin out, uses 5 days, and patient's self-induction is fully recovered.
Embodiment 2 treats the compound preparation of contact dermatitis, takes off and states the primary raw material of weight proportion and be prepared from (every Part takes 5g): Cortex Dictamni 10 parts, Radix Sophorae Flavescentis 9 parts, propolis 20 parts, Rhizoma Coptidis 20 parts, Aloe 15 parts, Flos Nelumbinis pollen 13 parts, Cortex Acanthopancis 10 Part, 10 parts of Pericarpium Citri Reticulatae Viride, Flos Lonicerae 7 parts, Indigo Naturalis 4 parts, 10 parts of Folium Mori, Cortex Pseudolaricis 8 parts, Rosehips oil 15 parts.
The preparation method of above-mentioned compound preparation, step is as follows:
(1) Aloe brush is cleaned down, remove thorn, then skin upper and lower for Folium Aloe is also removed, rinse gel with water, will Gel is put in juice extractor squeezing 6 minutes, filters off residue, obtains Aloe juice stand-by；
(2) propolis, Flos Nelumbinis pollen and Indigo Naturalis are gone the removal of impurity, tight with fresh Folium Nelumbinis parcel, it is placed on steaming tray and steams 40 points Clock, taking-up is dried in the air cool, and step (1) gained Aloe juice is together mixed with the propolis steamed, Flos Nelumbinis pollen and Indigo Naturalis with Rosehips oil Close, constantly stir with waddy, high temperature sterilize 30 seconds, bottle medicine is smeared in external；
(3) repeatedly stir-frying Cortex Dictamni, Rhizoma Coptidis and Cortex Acanthopancis to crisp, grinding to form smalls, to cross 120 mesh sieves stand-by；
(4) Radix Sophorae Flavescentis, Flos Lonicerae, Folium Mori and Cortex Pseudolaricis are together placed in transparent container, add the warm water of 40 DEG C, clean dry Only, chopping, with yellow wine, the crude drug of chopping to be mixed thoroughly, be placed in tinfoil, upper baking box is baked 7 minutes, takes out, dries in the air 30 minutes, lays On clean tile, little fire dries 8 minutes slowly, dries in the air to crisp, grinds to form smalls stand-by；
(5) being placed in marmite by Pericarpium Citri Reticulatae Viride, add the clear water of Pericarpium Citri Reticulatae Viride weight 10 times, big fire is boiled, and turns slow fire boiling 18 minutes, mistake Filter, filtrate is stand-by；
(6) step (3) and (4) gained smalls are mixed, add in step (5) gained filtrate, be placed on electromagnetic oven heating While stirring, adding dextrin after mixing thoroughly completely, obtain mixed liquor and cross 180 mesh drainage screens after dextrin melts completely, filtrate is Oral liquid medicine.
Embodiment 3 treats the compound preparation of contact dermatitis, takes off and states the primary raw material of weight proportion and be prepared from (every Part takes 15g): Cortex Dictamni 6 parts, Radix Sophorae Flavescentis 5 parts, propolis 13 parts, Rhizoma Coptidis 13 parts, Aloe 8 parts, Flos Nelumbinis pollen 9 parts, Cortex Acanthopancis 6 parts, blue or green Skin 6 parts, Flos Lonicerae 4 parts, Indigo Naturalis 2.5 parts, 6 parts of Folium Mori, Cortex Pseudolaricis 4 parts, Rosehips oil 8 parts.
Stating the preparation method of compound preparation, step is as follows:
(1) Aloe brush is cleaned down, remove thorn, then skin upper and lower for Folium Aloe is also removed, rinse gel with water, will Gel is put in juice extractor squeezing 3 minutes, filters off residue, obtains Aloe juice stand-by；
(2) propolis, Flos Nelumbinis pollen and Indigo Naturalis are gone the removal of impurity, tight with fresh Folium Nelumbinis parcel, it is placed on steaming tray and steams 25 points Clock, taking-up is dried in the air cool, and step (1) gained Aloe juice is together mixed with the propolis steamed, Flos Nelumbinis pollen and Indigo Naturalis with Rosehips oil Close, constantly stir with waddy, high temperature sterilize 15 seconds, bottle medicine is smeared in external；
(3) repeatedly stir-frying Cortex Dictamni, Rhizoma Coptidis and Cortex Acanthopancis to crisp, grinding to form smalls, to cross 90 mesh sieves stand-by；
(4) Radix Sophorae Flavescentis, Flos Lonicerae, Folium Mori and Cortex Pseudolaricis are together placed in transparent container, add the warm water of 33 DEG C, clean dry Only, chopping, with yellow wine, the crude drug of chopping to be mixed thoroughly, be placed in tinfoil, upper baking box is baked 4 minutes, takes out, dries in the air 15 minutes, lays On clean tile, little fire dries 4 minutes slowly, dries in the air to crisp, grinds to form smalls stand-by；
(5) being placed in marmite by Pericarpium Citri Reticulatae Viride, add the clear water of Pericarpium Citri Reticulatae Viride weight 6 times, big fire is boiled, and turns slow fire boiling 20 minutes, filters, Filtrate is stand-by；
(6) step (3) and (4) gained smalls are mixed, add in step (5) gained filtrate, be placed on electromagnetic oven heating While stirring, adding dextrin after mixing thoroughly completely, obtain mixed liquor and cross 190 mesh drainage screens after dextrin melts completely, filtrate is Oral liquid medicine.
Model case two: Zhu XX, female, 50 years old, Jinan, Shandong Province personage, the greening work in patient's long campaigns city, have one Secondary accidentally paint is dripped to cervical region when painting to trees brush, after two days, skin of neck flushing, swelling, and play intensive pimple, Pruritus.Come my institute, look into, locally color of the leather flushing, swelling, see there is intensive pimple, because premorbid has paint contact history, examine as contact Property dermatitis, doctor advised use and coordinate take gained of the present invention treatment contact dermatitis compound preparation.
Using the present embodiment 3 gained compound preparation, 1 day, remission, malaise symptoms significantly reduced, and adheres to having taken 5 My god, symptom disappears substantially, and patient's self-induction is fully recovered.
Embodiment 4 treats the compound preparation of contact dermatitis, takes off and states the primary raw material of weight proportion and be prepared from (every Part takes 20g): Cortex Dictamni 9 parts, Radix Sophorae Flavescentis 8 parts, propolis 18 parts, Rhizoma Coptidis 18 parts, Aloe 13 parts, Flos Nelumbinis pollen 11 parts, Cortex Acanthopancis 8 parts, 9 parts of Pericarpium Citri Reticulatae Viride, Flos Lonicerae 6 parts, Indigo Naturalis 3.5 parts, 9 parts of Folium Mori, Cortex Pseudolaricis 7 parts, Rosehips oil 13 parts.
The preparation method of above-mentioned compound preparation, step is as follows:
(1) Aloe brush is cleaned down, remove thorn, then skin upper and lower for Folium Aloe is also removed, rinse gel with water, will Gel is put in juice extractor squeezing 5 minutes, filters off residue, obtains Aloe juice stand-by；
(2) propolis, Flos Nelumbinis pollen and Indigo Naturalis are gone the removal of impurity, tight with fresh Folium Nelumbinis parcel, it is placed on steaming tray and steams 35 points Clock, taking-up is dried in the air cool, and step (1) gained Aloe juice is together mixed with the propolis steamed, Flos Nelumbinis pollen and Indigo Naturalis with Rosehips oil Close, constantly stir with waddy, high temperature sterilize 25 seconds, bottle medicine is smeared in external；
(3) repeatedly stir-frying Cortex Dictamni, Rhizoma Coptidis and Cortex Acanthopancis to crisp, grinding to form smalls, to cross 110 mesh sieves stand-by；
(4) Radix Sophorae Flavescentis, Flos Lonicerae, Folium Mori and Cortex Pseudolaricis are together placed in transparent container, add the warm water of 38 DEG C, clean dry Only, chopping, with yellow wine, the crude drug of chopping to be mixed thoroughly, be placed in tinfoil, upper baking box is baked 6 minutes, takes out, dries in the air 10-30 minute, paving Being located on clean tile, little fire dries 8 minutes slowly, dries in the air to crisp, grinds to form smalls stand-by；
(5) being placed in marmite by Pericarpium Citri Reticulatae Viride, add the clear water of Pericarpium Citri Reticulatae Viride weight 8 times, big fire boils, and turns slow fire boiling 25 minutes (preferably Turn slow fire boiling 23 minutes), filter, filtrate is stand-by；
(6) step (3) and (4) gained smalls are mixed, add in step (5) gained filtrate, be placed on electromagnetic oven heating While stirring, adding dextrin after mixing thoroughly completely, obtain mixed liquor and cross 210 mesh drainage screens after dextrin melts completely, filtrate is Oral liquid medicine.
Embodiment 5 treats the compound preparation of contact dermatitis, takes off and states the primary raw material of weight proportion and be prepared from (every Part takes 30g): Cortex Dictamni 7.5 parts, Radix Sophorae Flavescentis 6.5 parts, propolis 15 parts, Rhizoma Coptidis 15 parts, Aloe 10 parts, Flos Nelumbinis pollen 10 parts, Cortex Acanthopancis 7 parts, 7.5 parts of Pericarpium Citri Reticulatae Viride, Flos Lonicerae 5 parts, Indigo Naturalis 3 parts, 8 parts of Folium Mori, Cortex Pseudolaricis 5.5 parts, Rosehips oil 10 parts.
The preparation method of above-mentioned compound preparation, step is as follows:
(1) Aloe brush is cleaned down, remove thorn, then skin upper and lower for Folium Aloe is also removed, rinse gel with water, will Gel is put in juice extractor squeezing 4 minutes, filters off residue, obtains Aloe juice stand-by；
(2) propolis, Flos Nelumbinis pollen and Indigo Naturalis are gone the removal of impurity, tight with fresh Folium Nelumbinis parcel, it is placed on steaming tray and steams 30 points Clock, taking-up is dried in the air cool, and step (1) gained Aloe juice is together mixed with the propolis steamed, Flos Nelumbinis pollen and Indigo Naturalis with Rosehips oil Close, constantly stir with waddy, high temperature sterilize 20 seconds, bottle medicine is smeared in external；
(3) repeatedly stir-frying Cortex Dictamni, Rhizoma Coptidis and Cortex Acanthopancis to crisp, grinding to form smalls, to cross 100 mesh sieves stand-by；
(4) Radix Sophorae Flavescentis, Flos Lonicerae, Folium Mori and Cortex Pseudolaricis are together placed in transparent container, add the warm water of 35 DEG C, clean dry Only, chopping, with yellow wine, the crude drug of chopping to be mixed thoroughly, be placed in tinfoil, upper baking box is baked 5 minutes, takes out, dries in the air 20 minutes, lays On clean tile, little fire dries 6 minutes slowly, dries in the air to crisp, grinds to form smalls stand-by；
(5) being placed in marmite by Pericarpium Citri Reticulatae Viride, add the clear water of Pericarpium Citri Reticulatae Viride weight 7 times, big fire is boiled, and turns slow fire boiling 23 minutes, filters, Filtrate is stand-by；
(6) step (3) and (4) gained smalls are mixed, add in step (5) gained filtrate, be placed on electromagnetic oven heating While stirring, adding dextrin after mixing thoroughly completely, obtain mixed liquor and cross 200 mesh drainage screens after dextrin melts completely, filtrate is Oral liquid medicine.
Test example 1: the clinical practice of the compound preparation of embodiment 5 gained treatment contact dermatitis: we randomly draw 400 patients test (400 contact dermatitis patients), are divided into experimental group and matched group, before test 1 day, to this Crowd carries out Continuous Observation, record symptom and change, is randomly divided into two groups, experimental group and matched group, and experimental group uses embodiment 5 Products obtained therefrom, matched group takes the medicine of other treatment contact dermatitis.
Optimal using method: for making the present invention reach optimal therapeutic effect, the external made is smeared medicine and smeared number every day Secondary, directly it is put on affected part, oral liquid medicine, takes effect more preferably with 3 of afternoon, within 5 days, be one for 10 of every morning The course for the treatment of.
Efficacy evaluation: cure: after treatment, primary symptom disappears；Effective: after treatment, primary symptom takes a turn for the better, effectively: after treatment, primary symptom is Improve；Invalid: not up to effective standard.
Specific experiment result such as following table:
Table 1:
Therapeutic effect: compound preparation therapeutic effect of the present invention is substantially better than matched group, and during use, malaise symptoms occurs in no one Or side effect.

Claims (10)

1. treat the compound preparation of contact dermatitis, it is characterised in that: take off and state the primary raw material of weight proportion and be prepared from: be white Moss skin 5-10 part, Radix Sophorae Flavescentis 4-9 part, propolis 10-20 part, Rhizoma Coptidis 10-20 part, Aloe 5-15 part, Flos Nelumbinis pollen 7-13 part, Cortex Acanthopancis 4-10 part, Pericarpium Citri Reticulatae Viride 5-10 part, Flos Lonicerae 3-7 part, Indigo Naturalis 2-4 part, Folium Mori 5-10 part, Cortex Pseudolaricis 3-8 part, Rosehips oil 5-15 Part.
The compound preparation for the treatment of contact dermatitis the most according to claim 1, it is characterised in that: take off and state weight proportion Primary raw material is prepared from: Cortex Dictamni 6-9 part, Radix Sophorae Flavescentis 5-8 part, propolis 13-18 part, Rhizoma Coptidis 13-18 part, Aloe 8-13 part, lotus Flower pollen 9-11 part, Cortex Acanthopancis 6-8 part, Pericarpium Citri Reticulatae Viride 6-9 part, Flos Lonicerae 4-6 part, Indigo Naturalis 2.5-3.5 part, Folium Mori 6-9 part, Cortex Pseudolaricis 4-7 part, Rosehips oil 8-13 part.
The compound preparation for the treatment of contact dermatitis the most according to claim 1, it is characterised in that: take off and state weight proportion Primary raw material is prepared from: Cortex Dictamni 7.5 parts, Radix Sophorae Flavescentis 6.5 parts, propolis 15 parts, Rhizoma Coptidis 15 parts, Aloe 10 parts, Flos Nelumbinis pollen 10 Part, Cortex Acanthopancis 7 parts, 7.5 parts of Pericarpium Citri Reticulatae Viride, Flos Lonicerae 5 parts, Indigo Naturalis 3 parts, 8 parts of Folium Mori, Cortex Pseudolaricis 5.5 parts, Rosehips oil 10 parts.
4., according to the preparation method of the compound preparation of the treatment contact dermatitis described in any one of claim 1-3, its feature exists In: step is as follows:
(1) Aloe brush is cleaned down, remove thorn, then skin upper and lower for Folium Aloe is also removed, rinse gel with water, will Gel is put in juice extractor 2-6 minute (preferably 4 minutes) of squeezing, filters off residue, obtains Aloe juice stand-by；
(2) propolis, Flos Nelumbinis pollen and Indigo Naturalis are gone the removal of impurity, tight with fresh Folium Nelumbinis parcel, it is placed on steaming tray and steams 20-40 Minute, take out dry in the air cool, by step (1) gained Aloe juice and Rosehips oil together with the propolis steamed, Flos Nelumbinis pollen and Indigo Naturalis Mixing, constantly stir with waddy, the high temperature sterilize 10-30 second, bottle medicine is smeared in external；
(3) repeatedly stir-frying Cortex Dictamni, Rhizoma Coptidis and Cortex Acanthopancis to crisp, grinding to form smalls, to cross 80-120 mesh sieve stand-by；
(4) Radix Sophorae Flavescentis, Flos Lonicerae, Folium Mori and Cortex Pseudolaricis are together placed in transparent container, add the warm water of 30-40 DEG C, clean Totally, chopping, with yellow wine, the crude drug of chopping to be mixed thoroughly, be placed in tinfoil, upper baking box is baked 3-7 minute, takes out, and the 10-30 that dries in the air divides Clock, is laid on clean tile, and little fire dries 3-8 minute slowly, dries in the air to crisp, grinds to form smalls stand-by；
(5) being placed in marmite by Pericarpium Citri Reticulatae Viride, add the clear water of Pericarpium Citri Reticulatae Viride weight 4-10 times, big fire is boiled, and turns slow fire boiling 18-28 minute (preferably turning slow fire boiling 23 minutes), filters, and filtrate is stand-by；
(6) step (3) and (4) gained smalls are mixed, add in step (5) gained filtrate, be placed on electromagnetic oven heating While stirring, after mixing thoroughly completely, add dextrin, after dextrin melts completely, obtain mixed liquor cross 180-220 mesh drainage screen, filtrate It it is oral liquid medicine.
The preparation method of compound preparation the most according to claim 4, it is characterised in that: step (2) is with fresh Folium Nelumbinis bag Wrap up in tight, be placed on steaming tray to steam 25-35 minute and (preferably, wrap up tight with fresh Folium Nelumbinis, be placed on steaming tray and steam 30 points Clock).
The preparation method of compound preparation the most according to claim 4, it is characterised in that: step (3) grinds to form smalls and crosses 90- 110 mesh sieves stand-by (preferably, grind to form smalls cross 100 mesh sieves stand-by).
The preparation method of compound preparation the most according to claim 4, it is characterised in that: the consumption of step (4) yellow wine is mixed (preferably, the consumption of yellow wine is 0.4-0.6 times of mixing crude drug, more preferably, yellow wine to 0.3-0.7 times of conjunction crude drug Consumption be mixing 0.5 times of crude drug).
The preparation method of compound preparation the most according to claim 4, it is characterised in that: step (4) is dried in the air 15-25 minute, paving Being located on clean tile, little fire dries 4-7 minute slowly, and (preferably, drying in the air 20 minutes, be laid on clean tile, little fire dries 5 slowly Minute).
The preparation method of compound preparation the most according to claim 4, it is characterised in that: step (5) adds Pericarpium Citri Reticulatae Viride weight 6-8 Clear water again (preferably, adds the clear water of Pericarpium Citri Reticulatae Viride weight 7 times).
The preparation method of compound preparation the most according to claim 4, it is characterised in that: step (6) treats that dextrin melts completely After 190-210 mesh drainage screen (preferably after dextrin melts completely mixed liquor cross 200 mesh drainage screens) crossed by mixed liquor.
CN201610492052.4A 2016-06-29 2016-06-29 Compound preparation for treating contact dermatitis and preparation method thereof Pending CN105943799A (en)

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Cited By (2)

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WO2018000727A1 (en) * 2016-06-29 2018-01-04 李肖 Compound preparation for treating contact dermatitis and preparation method therefor
CN109498736A (en) * 2018-12-18 2019-03-22 深圳市沁园华诚农业科技有限公司 A kind of dermatitis spray and preparation method thereof

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CN105943799A (en) * 2016-06-29 2016-09-21 李肖 Compound preparation for treating contact dermatitis and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018000727A1 (en) * 2016-06-29 2018-01-04 李肖 Compound preparation for treating contact dermatitis and preparation method therefor
CN109498736A (en) * 2018-12-18 2019-03-22 深圳市沁园华诚农业科技有限公司 A kind of dermatitis spray and preparation method thereof

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Application publication date: 20160921