CN105943716A - Pharmaceutical composition used for treating Meniere disease - Google Patents
Pharmaceutical composition used for treating Meniere disease Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
- A61K36/835—Aquilaria
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention belongs to the technical field of traditional Chinese medicine, and relates to pharmaceutical composition used for treating Meniere disease and a preparation method thereof. The pharmaceutical composition is prepared from ammannia auriculata, inula flower, rattlesnake fern, Chinese holly leaf, Euonymus myrianthus, Chinese eaglewood, citron, alpine swertia and radix angelicae pubescentis. The drugs form a formula, so as to nourish liver and kidney, tranquilize liver and yang, invigorate spleen to dry, and naturally stop dizziness. Clinical observation found that the clinical effects of using pharmaceutical composition with western medicine for treating Meniere disease are obviously superior to the clinical effects of using western medicine only. The pharmaceutical composition has very good promotional value in grassroots community hoispitals.
Description
Technical field
The invention belongs to technical field of Chinese medicine, relate to a kind of for pharmaceutical composition treating Meniere and preparation method thereof.
Background technology
Meniere is considered as autonomic nervous system diseases, and hydrolabyrinth and local sympathetic nerve are disorderly with vagal balance
Disorderly both participate in the generating process of patient's deafness and tinnitus symptom.Tinnitus is probably primary disease symptom the earliest, and the initial stage can behave as continuing
Property low-key blowing sample, may occur in which the brouhaha of multiple tone late period.Tinnitus can occur suddenly before onset of vertigo or increase the weight of,
Phase tinnitus of having a rest disappears, and the sustainable existence of prolonged illness patient tinnitus, small number of patients can have bilateral tinnitus.Use dehydration, calmness clinically
The best Deng effect of conservative treatment, patient tinnitus and auditory dysesthesia degree there is no substantially alleviation.
Doctor trained in Western medicine some scholars is thought, the brain hydrolabyrinth of Meniere is its main pathological change, and attempts to be controlled by action of low-voltage pulse
Treat and alleviate lost high pressure, although vestibule dizziness can be alleviated, but for the improvement DeGrain of audition.Endolymphatic sac operation with
The long-term effect entering neurotomy of vestibular nerve after and is not affirmed, it is for the improvement DeGrain of hydrolabyrinth circulation simultaneously.
At present, doctor trained in Western medicine does not also have specially good effect, the Therapeutic Method of safety.
Meniere belongs to Chinese medicine " dizziness " category." Plain Questions the most pure virginity to be discussed greatly ": " all wind trembling and dizziness, come under liver ",
" Sheng of the moon of fainting, tinnitus dizziness ".Former worthies' cloud: " essence void is the most dizzy, suffers from a deficiency of the kidney, swoons ".Think that dizziness is the disease on top, mountain peak,
Liver-wind can cause trembling and dizziness, the weary deficiency of marrow-reservoir of kidney essense, then vertigo and tinnitus.This is for discussing the Main Basis of dizziness later age.Successive dynasties afterwards
Doctor has carried out substantial amounts of research to dizziness, summarizes forefathers and discusses the various viewpoints of dizziness etiology and pathogenesis, and is summarized
For wind, fire, expectorant, empty four aspects, advocate to carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs according to deficiency and excess difference.Modern Chinese medicine uses traditional Chinese medicine therapy section
Typically can obtain reliable curative effect, Therapeutic Method easily to operate and varied, low price, toxic and side effects is little, permissible
Alleviate the outbreak symptom of acute stage, it is also possible to enter to hold treatment in the catabasis and reduce seizure frequency.
Summary of the invention
Inventor is on the basis of older generation ancestor, in conjunction with the feature of modern, sums up clinical practice experience and thinks: disturb on liver-yang,
Expectorant of often holding concurrently is turbid for suffering from, and expectorant is turbid middle Jiao, and the wind sun of liver is exciting, and cause expectorant is with sun liter then, and the clear key of upper criminal, adverse rising of stomach-QI, evil is told
Sputum.A kind of pharmaceutical composition for treating Meniere is provided accordingly, patient clinical symptom can be significantly improved, improve
Therapeutic effect, treating both the principal and secondary aspects of a disease.
For achieving the above object, the present invention adopts the following technical scheme that
A kind of pharmaceutical composition for treating Meniere, it is characterised in that by ear water Herba Amaranthi tricoloris, Flos Inulae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Folium Mahoniae,
Radix Euonymi myrianthi, Lignum Aquilariae Resinatum, Fructus Citri, Herba Swertiae heteranthae, Radix Angelicae Pubescentis are made.
Inventor tests through screening prescription long-term, substantial amounts of, following technical scheme: one is used for treating prunus mume (sieb.) sieb.et zucc. Buddhist nun
Angstrom sick pharmaceutical composition, it is characterised in that be made up of the medicinal raw material of following weight parts proportioning: ear water Herba Amaranthi tricoloris 20-25 part, Flos Inulae
8-13 part, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 8-13 part, Folium Mahoniae 13-18 part, Radix Euonymi myrianthi 20-25 part, Lignum Aquilariae Resinatum 2.5-3.5 part, Fructus Citri 6-11 part, crow
Gold grass 8-13 part, Radix Angelicae Pubescentis 5-8 part.
It is further preferred that a kind of pharmaceutical composition for treating Meniere, it is characterised in that by following weight parts proportioning
Medicinal raw material is made: ear water Herba Amaranthi tricoloris 20 parts, Flos Inulae 10 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 10 parts, Folium Mahoniae 15 parts, Radix Euonymi myrianthi 22 parts, Lignum Aquilariae Resinatum
3.0 parts, Fructus Citri 8 parts, Herba Swertiae heteranthae 12 parts, Radix Angelicae Pubescentis 6 parts, or ear water Herba Amaranthi tricoloris 25 parts, Flos Inulae 12 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 12 parts, Folium Mahoniae
16 parts, Radix Euonymi myrianthi 24 parts, Lignum Aquilariae Resinatum 3.0 parts, Fructus Citri 8 parts, Herba Swertiae heteranthae 10 parts, Radix Angelicae Pubescentis 6 parts.
Fang Zhong: Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. is apt to suppressing the hyperactive liver eliminating stagnation, expelling wind for relieving convulsion, heat-clearing and toxic substances removing；Folium Mahoniae takes a tonic or nourishing food to build up one's health cloudy gas, clearing away heat and nourishing YIN, suppressing the hyperactive liver
Kidney tonifying, two medicines 5 are the most dizzy with suppressing the hyperactive liver, QI invigorating soothing liver-QI, and purging liver-fire is monarch drug.Ear water Herba Amaranthi tricoloris is sweet light flat, kind invigorating spleen to remove dampness, circulation of qi promoting
Dissipating blood stasis；The salty temperature of Flos Inulae, kind softening the hard mass expectorant, therapeutic method to keep the adverse QI flowing downwards row water, two medicine 5 invigorating spleen to remove dampness, circulation of qi promoting expectorant, water of can dispelling wet with,
Eliminating phlegm retention, can dispel wind syndrome of head by promoting blood circulation again, for ministerial drug, the monarch and his subjects play effect of drink, calmly dizzy preventing or arresting vomiting of dispelling of reducing phlegm altogether.Radix Euonymi myrianthi benefit
Kidney strengthens waist, blood stasis dispelling dampness removing；Fructus Citri suppressing the hyperactive liver Shu Yu, alleviating distention in middle-JIAO reduces phlegm, invigorating the spleen and regulating the stomach preventing or arresting vomiting, and stimulate the menstrual flow diuretic；Herba Swertiae heteranthae nourishes blood suppressing the hyperactive liver,
Tranquilizing by nourishing the heart；Radix Angelicae Pubescentis is pungent sensible strongly fragrant, sending up the lucid YANG, tonifying liver gas, and embolden gas；The pure sun of Lignum Aquilariae Resinatum and rise, body weight and sink, acrid in the mouth is wandered away,
Gas hero is walked crosswise, therefore has exceedingly high ability merit, kind expulsion pathogen, and energy dissipating blood stasis analgesic therapy can be calmed the nerves by sending down the abnormal ascending QI, energy dredging the meridian, can make
Blood turns with gas with gas row, expectorant, can adjust can and, be all adjuvant.All medicine conjunction sides, with replenishing the kidney(water)to nourish the liver(wood), suppressing the hyperactive liver and subsiding YANG, spleen invigorating is dry
Wet, dizziness is from only.Clinical observation finds that it coordinates the clinical efficacy of western medicine Meniere to be substantially better than simple western medicine group,
There is good promotional value in hospital of grass-roots community.
Meridian distribution of property and flavor and the primary efficacy of each medicinal raw material used by the present invention are as follows.
Ear water Herba Amaranthi tricoloris: [nature and flavor] sweet in the mouth；Light；Property flat.[return through] returns spleen；Bladder warp.[function cures mainly] invigorating spleen to remove dampness；OK
Gas dissipating blood stasis.Main Spleen deficiency anorexia；Chest and diaphragm is full vexed；Acute and chronic cystitis；Women's leukorrhagia；Traumatic injury congestive edema is had a pain.
Flos Inulae: [nature and flavor] are salty, temperature.[function cures mainly] expectorant, the therapeutic method to keep the adverse QI flowing downwards, softening the hard mass, row water.Control expectorant knot in the heart, under the side of body
Distension, cough with asthma, singultus, saliva such as shellac varnish, epigastric oppression, eructation unrelieved, extensive abdominal edema.
Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw.: [taste] is bitter；Puckery；Cool；Sweet；It is slightly cold.[return through] lung；Liver Channel.Heat-clearing and toxic substances removing；Suppressing the hyperactive liver eliminating stagnation；
Expelling wind for relieving convulsion.Main lung abscess；Venom；Conjunctival congestion；Scrofula；Cough；Snake venom；Acute infantile convulsion wind；Rheumatic arthralgia；Traumatic injury damages
Wound.
Folium Mahoniae: [nature and flavor] are bitter；Cool.[return through] liver；Kidney channel.[function cures mainly] clearind deficient heat；Liver and kidney tonifying；Dispel the wind
Wet.Main hectic fever due to deficiency of YIN；Cough spitting of blood；Have a dizzy spell；Soreness of the waist and knees；Rheumatic arthralgia；Vitiligo.In [usage and dosage]
Clothes: decoct soup, 9-15g.
Radix Euonymi myrianthi: [nature and flavor] are sweet；Micro-hardship；Flat.[return through] liver；Spleen；Kidney channel.[function cures mainly] kidney tonifying strengthens waist；Change
Stasis of blood dampness removing.Main lumbago due to renal deficiency；Frequent fetal movement；Chronic nephritis；Prolonged lochia；Injury and bone fracture；Rheumatic arthralgia；Leukorrhagia.
Lignum Aquilariae Resinatum: [nature and flavor] are pungent, bitter, tepor.[return through] returns spleen, stomach, kidney channel.[function cures mainly] promoting the circulation of QI to relieve pain, warming middle-JIAO
Preventing or arresting vomiting, helping inspiration to relieve asthma.For chest and abdomen feeling of distension and oppression pain, gastrofrigid vomiting singultus, QI rising in reverse order of suffering from a deficiency of the kidney dyspnea with rapid respiration.[usage and dosage] 1.5～
4.5g, enter decoct preferably after under.
Fructus Citri: [nature and flavor] are pungent, bitter, sour, temperature.[return through] returns liver, spleen, lung meridian.[function cures mainly] liver-smoothing, qi-regulating, wide
In, reduce phlegm.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavity abdomen feeling of fullness, vomitting eructation, abundant expectoration is coughed.[usage and dosage] 3～
9g。
Herba Swertiae heteranthae: [nature and flavor] are sweet；Micro-hardship；Property flat.[return through] heart；Liver Channel.[function cures mainly] suppressing the hyperactive liver sun；Tranquilizing by nourishing the heart；
Nourishing blood for regulating menstruation.Main dizziness；Neurasthenia；Hypertension；Anemia；Menoxenia.[usage and dosage] takes orally: decoct soup, 6-10g.
Radix Angelicae Pubescentis: [nature and flavor] are pungent, bitter, tepor.[return through] returns kidney, bladder warp.[function cures mainly] expelling wind and removing dampness, blood stasis dispelling is only
Bitterly.For anemofrigid-damp arthralgia, lumbocrural pain, few the moon volt wind headache.[usage and dosage] 3～9g.
For the ease of use, the pharmaceutical composition of the present invention can by ear water Herba Amaranthi tricoloris, Flos Inulae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Folium Mahoniae, Radix Euonymi myrianthi,
Lignum Aquilariae Resinatum, Fructus Citri, Herba Swertiae heteranthae, Radix Angelicae Pubescentis or its water or its extractive with organic solvent are active component, according to galenic pharmacy routine techniques system
Become peroral dosage form, such as: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule
Agent, oral liquid, granule, electuary, pill, powder, suspensoid, powder.
Pharmaceutical composition the most described above can also add pharmaceutically acceptable carrier, such as: mannitol, sorbitol, Jiao
Sodium sulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, injection Vitamin B_6 DTA
Disodium, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid,
Phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, sweet
Propylhomoserin, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, poly-second
Alkene pyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin,
Beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc..
Preferably, peroral dosage form described above is capsule, tablet, oral liquid, granule or pill.
Most preferably, peroral dosage form described above is capsule.
Present invention also offers the preparation method of a kind of medicament composition capsule agent described above, the present inventor is in research
Middle discovery, by optimizing preparation method, it is possible in the case of keeping active drug, go the removal of impurity or the part without drug effect,
Reduce the impurity interference to therapeutic effect so that this pharmaceutical composition is more easy to enter into diseased region.
The preparation method of a kind of medicament composition capsule agent for treating Meniere that the present invention provides, it is characterised in that bag
Include following steps:
(1) take Flos Inulae, Radix Angelicae Pubescentis, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Lignum Aquilariae Resinatum pulverizing, mixing by prescription, add 3～the concentration of 8 times of weight portions is 45%-55%
The alcohol reflux of (preferably 50%) 1-3 time, the time being every time heated to reflux is 0.5～2 hour, collects Flos Inulae, solely
Work, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Lignum Aquilariae Resinatum ethanol extraction after filtering residue, united extraction liquid, filter, concentrating under reduced pressure becomes thick paste；
(2) by prescription weigh ear water Herba Amaranthi tricoloris, Folium Mahoniae, Radix Euonymi myrianthi, Fructus Citri, Herba Swertiae heteranthae and Flos Inulae, Radix Angelicae Pubescentis, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw.,
Filtering residue mixing after Lignum Aquilariae Resinatum ethanol extraction, the water boiling and extraction of 4～10 times of weight portions of addition 2 times, each decocting time is 1～2
Hour, united extraction liquid, filter, stand, take supernatant, concentrating under reduced pressure becomes thick paste；
(3) thick paste mixing step (1) and step (2) obtained, is ground into the fine powder of 300-400 mesh after lyophilization,
Add relative to fine powder quality 0.05～the microcrystalline Cellulose of 0.3 times, the starch of 0.01～0.3 times, 0.005～0.05 times hard
Fatty acid magnesium, carries out mixing process, loads capsule shells and i.e. obtain Chinese medicine capsules of the present invention after sterilizing.
The present invention be inventor through repeatedly studying, progressively improve a kind of curative effect obtained preferably for treating Meniere
Medicine.The results of animal of embodiment 9:
Medicine of the present invention causes the result of the test that affects of domestic cat vomiting and shows hydrochloric acid Apomorphinum: medicine of the present invention can significantly reduce
Caused by Apomorphinum, the number of times of domestic cat vomiting, compares with matched group and has significant difference (P ＜ 0.05, P ＜ 0.01)；
Medicine of the present invention rabbit is inversely turn-taked syndromes models improvement result test show: medicine of the present invention large and small dosage group
All can reduce rabbit inversely to turn-take the generation of syndromes models symptom, reduce mortality rate；
The Experiment on Function of experimental endolymphatic hydrops is shown by medicine of the present invention: medicine of the present invention has and alleviates experimental endolymph
The effect of hydrops, and improve be induced by tragus cytopathy, disappearance, stria vascularis atrophy, spiral ganglion degeneration, listen
Power is damaged with vestibular function, and with the increase of drug dose, effect increases.
Meanwhile, the clinical test results of the embodiment of the present invention 10 shows: treatment group patient's vertigo symptoms is obviously improved, and improves journey
Degree is better than matched group, and after treatment, the vertigo symptoms treatment total effective rate for the treatment of group patient reaches 86.8%, has pointed out medicine of the present invention to join
Close treatment, both can rapid relief of symptoms, again can Control in recurring, treating both the principal and secondary aspects of a disease, fully demonstrated the organic conception of theory of Chinese medical science with
Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, therefore curative effect is preferable.Therefore the present invention is also claimed pharmaceutical composition described above at preparation treatment Meniere medicine
Purposes in thing, and the purposes in preparation treatment Meniere liver-Yang sthenia type medicine.
In a word, compared with prior art, the method have the advantages that we's prescription is rigorous, flavour of a drug are fewer but better, link closely
Pathogenesis, has the regulation effect of Mutiple Targets, multisystem, thus reaches to treat the purpose of Meniere.And combine healing with Western medicine
There is synergism, significantly improve clinical symptoms, improve therapeutic effect, be to be worth praising highly the main for the treatment of Meniere
Method.
Detailed description of the invention
Further describing the present invention below by way of specific embodiment, the present invention is not limited only to following example.Model in the present invention
Enclose interior or without departing from present disclosure, spirit and scope, change that the present invention is carried out, combine or replace, for
It is apparent from for those skilled in the art, and is included within the scope of the present invention.
Embodiment 1 capsule
Prescription: ear water Herba Amaranthi tricoloris 20 parts, Flos Inulae 10 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 10 parts, Folium Mahoniae 15 parts, Radix Euonymi myrianthi 22 parts, Lignum Aquilariae Resinatum 3.0 parts,
Fructus Citri 8 parts, Herba Swertiae heteranthae 12 parts, Radix Angelicae Pubescentis 6 parts.
Preparation method: (1) takes Flos Inulae by prescription, Radix Angelicae Pubescentis, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Lignum Aquilariae Resinatum are pulverized, mixing, adds 3～8 times of weight portions
Concentration is the alcohol reflux 2 times of 50%, and the time being every time heated to reflux is 0.5～2 hour, collects Flos Inulae, Radix Angelicae Pubescentis, spring
Lose, filtering residue after the ethanol extraction of Lignum Aquilariae Resinatum, united extraction liquid, filter, concentrating under reduced pressure becomes thick paste；
(2) by prescription weigh ear water Herba Amaranthi tricoloris, Folium Mahoniae, Radix Euonymi myrianthi, Fructus Citri, Herba Swertiae heteranthae and Flos Inulae, Radix Angelicae Pubescentis, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw.,
Filtering residue mixing after Lignum Aquilariae Resinatum ethanol extraction, the water boiling and extraction of 4～10 times of weight portions of addition 2 times, each decocting time is 1～2
Hour, united extraction liquid, filter, stand, take supernatant, concentrating under reduced pressure becomes thick paste；
(3) thick paste mixing step (1) and step (2) obtained, is ground into the fine powder of 400 mesh, adds after lyophilization
Enter the microcrystalline Cellulose relative to fine powder quality 0.10 times, the starch of 0.15 times, the magnesium stearate of 0.008 times, carry out at mixing
Reason, loads capsule shells and i.e. obtains Chinese medicine capsules of the present invention after sterilizing.Every loading amount 0.30g of the present embodiment capsule, is equivalent to raw
Medicine 1.06g.
Embodiment 2 capsule
Prescription: ear water Herba Amaranthi tricoloris 25 parts, Flos Inulae 12 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 12 parts, Folium Mahoniae 16 parts, Radix Euonymi myrianthi 24 parts, Lignum Aquilariae Resinatum 3.0
Part, Fructus Citri 8 parts, Herba Swertiae heteranthae 10 parts, Radix Angelicae Pubescentis 6 parts.
Ear water Herba Amaranthi tricoloris 20-25 part, Flos Inulae 8-13 part, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 8-13 part, Folium Mahoniae 13-18 part, Radix Euonymi myrianthi 20-25 part, heavy
Fragrant 2.5-3.5 part, Fructus Citri 6-11 part, Herba Swertiae heteranthae 8-13 part, Radix Angelicae Pubescentis 5-8 part.
Preparation method: (1) takes Flos Inulae by prescription, Radix Angelicae Pubescentis, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Lignum Aquilariae Resinatum are pulverized, mixing, adds 3～8 times of weight portions
Concentration is the alcohol reflux 2 times of 50%, and the time being every time heated to reflux is 0.5～2 hour, collects Flos Inulae, Radix Angelicae Pubescentis, spring
Lose, filtering residue after the ethanol extraction of Lignum Aquilariae Resinatum, united extraction liquid, filter, concentrating under reduced pressure becomes thick paste；
(2) by prescription weigh ear water Herba Amaranthi tricoloris, Folium Mahoniae, Radix Euonymi myrianthi, Fructus Citri, Herba Swertiae heteranthae and Flos Inulae, Radix Angelicae Pubescentis, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw.,
Filtering residue mixing after Lignum Aquilariae Resinatum ethanol extraction, the water boiling and extraction of 8 times of weight portions of addition 2 times, each decocting time is 1～2 hour,
United extraction liquid, filters, and stands, takes supernatant, and concentrating under reduced pressure becomes thick paste；
(3) thick paste mixing step (1) and step (2) obtained, is ground into the fine powder of 400 mesh, adds after lyophilization
Enter the microcrystalline Cellulose relative to fine powder quality 0.08 times, the starch of 0.14 times, the magnesium stearate of 0.01 times, carry out at mixing
Reason, loads capsule shells and i.e. obtains Chinese medicine capsules of the present invention after sterilizing.Every loading amount 0.32g of the present embodiment capsule, is equivalent to raw
Medicine 1.16g.
Embodiment 3 capsule
Prescription: ear water Herba Amaranthi tricoloris 20 parts, Flos Inulae 10 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 8 parts, Folium Mahoniae 15 parts, Radix Euonymi myrianthi 25 parts, Lignum Aquilariae Resinatum 3.0 parts,
Fructus Citri 8 parts, Herba Swertiae heteranthae 12 parts, Radix Angelicae Pubescentis 6 parts.
Preparation method: (1) takes Flos Inulae by prescription, Radix Angelicae Pubescentis, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Lignum Aquilariae Resinatum are pulverized, mixing, adds 3～8 times of weight portions
Concentration is the alcohol reflux 3 times of 48%, and the time being every time heated to reflux is 0.5～2 hour, collects Flos Inulae, Radix Angelicae Pubescentis, spring
Lose, filtering residue after the ethanol extraction of Lignum Aquilariae Resinatum, united extraction liquid, filter, concentrating under reduced pressure becomes thick paste；
(2) by prescription weigh ear water Herba Amaranthi tricoloris, Folium Mahoniae, Radix Euonymi myrianthi, Fructus Citri, Herba Swertiae heteranthae and Flos Inulae, Radix Angelicae Pubescentis, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw.,
Filtering residue mixing after Lignum Aquilariae Resinatum ethanol extraction, the water boiling and extraction of 6 times of weight portions of addition 2 times, each decocting time is 1～2 hour,
United extraction liquid, filters, and stands, takes supernatant, and concentrating under reduced pressure becomes thick paste；
(3) thick paste mixing step (1) and step (2) obtained, is ground into the fine powder of 300-400 mesh after lyophilization,
Add relative to microcrystalline Cellulose, starch, magnesium stearate, carry out mixing process, load capsule shells after sterilizing and i.e. obtain the present invention
Chinese medicine capsules.
Embodiment 4 capsule
Prescription: ear water Herba Amaranthi tricoloris 20 parts, Flos Inulae 10 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 10 parts, Folium Mahoniae 18 parts, Radix Euonymi myrianthi 20 parts, Lignum Aquilariae Resinatum 2.8 parts,
Fructus Citri 9 parts, Herba Swertiae heteranthae 8 parts, Radix Angelicae Pubescentis 8 parts.
Preparation method: (1) takes Flos Inulae by prescription, Radix Angelicae Pubescentis, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Lignum Aquilariae Resinatum are pulverized, mixing, adds 3～8 times of weight portions
Concentration is the alcohol reflux 2 times of 52%, and the time being every time heated to reflux is 0.5～2 hour, collects Flos Inulae, Radix Angelicae Pubescentis, spring
Lose, filtering residue after the ethanol extraction of Lignum Aquilariae Resinatum, united extraction liquid, filter, concentrating under reduced pressure becomes thick paste；
(2) by prescription weigh ear water Herba Amaranthi tricoloris, Folium Mahoniae, Radix Euonymi myrianthi, Fructus Citri, Herba Swertiae heteranthae and Flos Inulae, Radix Angelicae Pubescentis, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw.,
Filtering residue mixing after Lignum Aquilariae Resinatum ethanol extraction, the water boiling and extraction of 8 times of weight portions of addition 2 times, each decocting time is 1～2 hour,
United extraction liquid, filters, and stands, takes supernatant, and concentrating under reduced pressure becomes thick paste；
(3) thick paste mixing step (1) and step (2) obtained, is ground into the fine powder of 300-400 mesh after lyophilization,
Add relative to microcrystalline Cellulose, starch, magnesium stearate, carry out mixing process, load capsule shells after sterilizing and i.e. obtain the present invention
Chinese medicine capsules.
Embodiment 5 capsule
Prescription: ear water Herba Amaranthi tricoloris 22 parts, Flos Inulae 10 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 8 parts, Folium Mahoniae 16 parts, Radix Euonymi myrianthi 22 parts, Lignum Aquilariae Resinatum 3.2 parts,
Fructus Citri 6 parts, Herba Swertiae heteranthae 10 parts, Radix Angelicae Pubescentis 5 parts.
Preparation method: the operation with reference to embodiment 1-4 is carried out.
Embodiment 6 capsule
Prescription: ear water Herba Amaranthi tricoloris 25 parts, Flos Inulae 12 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 10 parts, Folium Mahoniae 16 parts, Radix Euonymi myrianthi 22 parts, Lignum Aquilariae Resinatum 3.0 parts,
Fructus Citri 8 parts, Herba Swertiae heteranthae 12 parts, Radix Angelicae Pubescentis 7 parts.
Preparation method: the operation with reference to embodiment 1-4 is carried out.
Embodiment 7 capsule
Prescription: ear water Herba Amaranthi tricoloris 25 parts, Flos Inulae 12 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 13 parts, Folium Mahoniae 13 parts, Radix Euonymi myrianthi 25 parts, Lignum Aquilariae Resinatum 2.5 parts,
Fructus Citri 10 parts, Herba Swertiae heteranthae 8 parts, Radix Angelicae Pubescentis 6 parts.
Preparation method: the operation with reference to embodiment 1-4 is carried out.
Embodiment 8 capsule
Prescription: ear water Herba Amaranthi tricoloris 20 parts, Flos Inulae 13 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 12 parts, Folium Mahoniae 15 parts, Radix Euonymi myrianthi 22 parts, Lignum Aquilariae Resinatum 3.3 parts,
Fructus Citri 10 parts, Herba Swertiae heteranthae 10 parts, Radix Angelicae Pubescentis 7 parts.
Preparation method: the operation with reference to embodiment 1-4 is carried out.
Embodiment 9 zoopery
(1) toxicological experiment:
Acute toxicity testing result shows: by the medicine Cmax of the embodiment of the present invention 1, maximum volume gastric infusion, in 24h
Successive administration 3 times, every minor tick 4h, accumulation medicine total amount reaches 40g crude drug/kg, is equivalent to people's clinic and intends 126.3 times of consumption.
After administration in 7d, mice is movable, take food, drain all normally, well-grown, hair color light, when its average body weight average is with test
Between prolongation and increase.Post mortem every the mice perusal heart at 8d, liver, spleen, lung, kidney, brain, thymus, stomach,
Intestinal etc. all do not find color and paramophia, fail to measure LD50.Show that medicine of the present invention is without acute toxic reaction.
Long term toxicity test result shows: drug component of the present invention be basic, normal, high dosage be respectively 1.06,4.24,8.5g raw
Medicine/kg/d, twice daily, gastric infusion is after 12 weeks, and medicine of the present invention is raw to the general status of animal, hematological indices, blood
Change index all without significantly impact, the most no abnormal pathological change of Systematic anatomy, organ coefficient and histopathological examination.Stop
Medicine also has no substantially change for 2 weeks.Medicine of the present invention, in long term toxicity test, does not finds that overt toxicity reaction and delayed toxicity are anti-
Should.Visible, medicine non-toxic reaction of the present invention, long-term prescription is safe and reliable.
(2) medicine of the present invention causes the impact of domestic cat vomiting to hydrochloric acid Apomorphinum
1 experiment material
1.1 animals: domestic cat, male and female have concurrently, body weight 500～800g.
1.2 medicines: large, medium and small three the dosage groups of medicine of the present invention.Medicine configures with normal saline on pretreatment, and gavage is given
Medicine, is administered by 10ml/kg.
2 experimental techniques: domestic cat 40, male and female half and half, body weight 500～800g, it is randomly divided into 4 groups, often group 10.
The normal saline of matched group gavage same volume；High, medium and low group of the medicine of the embodiment of the present invention 1 respectively gastric infusion 8.5,3.18,
1.06g crude drug/kg；Successive administration 7d, after last is administered 1h, by 0.35mg/kg injected sc hydrochloric acid Apomorphinum
Solution, each treated animal vomiting number of times in record 1h.
3 experimental results: be shown in Table 1.
Table 1 causes the impact of domestic cat vomiting to hydrochloric acid Apomorphinum
Compared with matched group, * P ＜ 0.05, * * P ＜ 0.01.
Result shows: medicine of the present invention can significantly reduce the number of times of domestic cat vomiting caused by Apomorphinum, compares with matched group and has significance
Difference (P ＜ 0.05, P ＜ 0.01).Visible, medicine of the present invention has the effect that certain central town is told.
(3) rabbit is inversely turn-taked the improvement result of syndromes models
Take New Zealand white rabbit 75, be randomly divided into 5 groups, i.e. sham operated rats, blank group (gavage gives normal saline),
Drug bolus group of the present invention (the pharmaceutical composition 4.24g crude drug of embodiment 1/kg/ rabbit/day), medicine small dose group of the present invention
(the pharmaceutical composition 2.12g crude drug of embodiment 1/kg/ rabbit/day) and scopolamine matched group, animal gastric infusion is after 7 days
Make syndromes models of inversely turn-taking, observe 3 days animal survival numbers and number of animals of turn-taking, continue during observation to be administered.Result is originally
Invention medicine large and small dosage group all can reduce rabbit and inversely turn-take the generation of syndromes models symptom, reduces mortality rate.
(4) effect to experimental endolymphatic hydrops: take 200～300g albino guinea-pig 40, is randomly divided into 4 groups: (1)
Normal group 10, raises 60 days；(2) hydrops group 10, row endolymphatic sac (ELS) and meat lymphatic ducts (ELD) resistance
Fill in postoperative, survive and test for 60 days；(3) being administered 1 group 10, after row ELS and ELD occlusion 30 days start mouth
Take the pharmaceutical capsules of the embodiment of the present invention 1,2/day, test after taking 30 days；(4) 2 groups 10 it are administered, row ELS
With the pharmaceutical capsules that ELD occlusion starts the oral embodiment of the present invention 1 after 30 days, 4/day, test after 30 days.
Checked by vestibular function mensuration, cochlea sheet electrograph, cochlear observation form, temporal bone section light microscopic etc..Result shows administration group
There is the effect alleviating experimental endolymphatic hydrops, and improve be induced by tragus cytopathy, disappearance, stria vascularis atrophy,
Spiral ganglion degeneration, audition are damaged with vestibular function, and with the increase of drug dose, effect increases.
The observation of curative effect examining auditory vertigo patient is tested by embodiment 10 medicine of the present invention
Data and method
1.1 physical data: choose 102 examples and make a definite diagnosis the patient of Meniere, are divided into treatment group 53 example, matched group 49 example.
In treatment group patient, male 13 example, women 40 example；Age 31～74 years old, year mean age (48.5 ± 11.2)；Averagely
The course of disease (3.3 ± 1.8) year；Left ear 27 example, auris dextra 26 example；Dizziness obstacle scale (Dizziness handicap before treatment
Inventory, DHI) scoring (83.2 ± 7.4) point.In matched group patient, male 11 example, women 38 example；Age 34～
76 years old, year mean age (50.1 ± 11.8)；Average course of disease (3.5 ± 2.1) year；Left ear 26 example, auris dextra 23 example；
Before treatment, DHI scoring (81.4 ± 8.0) divides.The above-mentioned physical data of two groups of patients compares, difference equal not statistically significant (P
＞ 0.05), there is comparability.
1.2 diagnostic criteria
1.2.1 Western medicine diagnose: according to Society of Otorhinolaryngology of Chinese Medical Association " department of otorhinolaryngology disconnected treatment volume " Guan Mei in 1997
The sick diagnostic criteria of Buddhist nun angstrom is as follows: the rotatory vertigo of recurrent exerbation, continues several tens minutes little to number, at least outbreak 2 times
Above.Often make Nausea and vomiting, disequilibrium.Unconscious forfeiture.Level or horizontal rotation type nystagmus can be accompanied.At least one times
Pure tone test is Sensorineural hearing loss.Low frequency auditory dysesthesia in early days, listens fluctuation, with feelings progress hearing loss gradually
Increase the weight of.May occur in which recruitment phenomenon.Tinnitus, intermittent or persistence, change before and after onset of vertigo more.Bulge of the ear may be had full
Sense.
1.2.2 TCM syndrome diagnosis TCM syndrome diagnostic criteria is according to " new Chinese medicine guideline of clinical investigations " and " tcm internal medicine
Disease treatment is conventional " draft excessive rising of liver-YANG.Primary symptom: dizziness is shown effect because of anxious state of mind or increases the weight of.Secondary disease: disposition usually is anxious
Hot-tempered, breast side of body feeling of distension and oppression.Tongue arteries and veins: red tongue, yellow fur, stringy pulse.
1.3 include in and exclusion standard: this test is also signed in the know through hospital's Medical Ethics Committee approval, the equal informed consent of patient
Letter of consent.Exclusion standard (1) eye source property, ear source property, positional, drug induccd dizziness；(2) cerebral infarction, cerebral hemorrhage, tumor
And cervical vertebra or the dizziness caused by basis cranii congenital malformation, superior aperture of thorax syndrome, cervical trauma；(3) merge severe cardiac, liver,
Brain, kidney diaseases and mental sickness person；(4) to Western medicine or Chinese medicine allergy and use other treatment vertigo medicament person simultaneously；(5) pregnant
Be pregnent, women breast-feeding their children and 70 years old person of age ＞.
1.4 Therapeutic Method: matched group patient uses low molecular dextran (500ml/ bottle) 500ml to add adenosine triphosphate
(ATP), coenzyme A intravenous drip, qd.Treatment group patient gives the glue of the embodiment of the present invention 1 preparation on the basis of matched group
Capsule is treated, twice on the one, each 4-6 grain.7d is 1 course for the treatment of, and two groups of patients all treat 2 courses for the treatment of.
1.5 observation index: the influence degree that before and after using DHI evaluation to treat, the quality of life of patient is caused by vertigo symptoms,
This scale includes emotionality, the content of three aspects functional, physical, and 25 altogether, full marks 100 points, score is the lowest
Represent that vertigo symptoms is the lowest to the influence degree of patient.
Clinical efficacy after terminating two groups of patient treatments is evaluated: examine according to the Meniere that Kweiyang meeting in 2006 is formulated
Disconnected standard (after using treatment 18～within 24 months, ask that onset of vertigo number of times compares with treating first 6 months onset of vertigo number of times,
Based on score value: after institute's score value=treatment 18～onset of vertigo number of times between 24 months/treat first 6 months onset of vertigo × 100),
Dizziness therapeutic outcome is divided into: control (0 point), basic controlling (1～40 point), partly control (41～80 points) completely,
Do not control (81～120 points), increase the weight of (＞ 120 points), total effective rate=(controlling number of cases+basic controlling number of cases completely)/sample
This number of cases × 100%.
1.6 statistical analysis: using spss16.0 statistical software to be analyzed, the comparison of enumeration data two sample rate uses X2
Inspection, measurement data withRepresent, compare before and after treatment with paired t-test, between group, compare employing t inspection, P ＜ 0.05
Represent that difference is statistically significant.
2 results
DHI scoring change before and after 2.1 liang of group patient treatments: before treatment, the DHI scoring of two groups of patients is compared, no statistical difference
Meaning (P ＞ 0.05)；After treatment, significantly reduce before the DHI scoring relatively treatment of two groups of patients, and treatment group is substantially less than comparison
Group, difference statistically significant (P ＜ 0.05).Before and after two groups of patient treatments, DHI scoring change is shown in Table 2.
DHI scoring change before and after 2 liang of table group patient treatment (Point)
Note: compare with treatment, * P ＜ 0.05, * * P ＜ 0.01；Compare between group,#P ＜ 0.05.
2.2 liang of group patient's vertigo symptoms improve situation: vertigo symptoms treatment total effective rate (86.8%) for the treatment of group patient is significantly high
In matched group (59.2%), difference statistically significant (P ＜ 0.05).Two groups of patient's vertigo symptoms improve situation and are shown in Table 3.
3 liang of table group patient's vertigo symptoms improves situation, example
Note: matched group compares, * P ＜ 0.05.
The study find that treatment group patient's vertigo symptoms is obviously improved, and improvement degree is better than matched group, treatment group patient after treatment
Vertigo symptoms treatment total effective rate reach 86.8%, the clinical efficacy having pointed out treated with combined medication of the present invention is preferable.
Claims (10)
1. the pharmaceutical composition being used for treating Meniere, it is characterised in that by ear water Herba Amaranthi tricoloris, Flos Inulae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., contribution
Leaf, Radix Euonymi myrianthi, Lignum Aquilariae Resinatum, Fructus Citri, Herba Swertiae heteranthae, Radix Angelicae Pubescentis are made.
2. the pharmaceutical composition treating Meniere as claimed in claim 1, it is characterised in that by the medicine of following weight parts proportioning
Make with raw material: ear water Herba Amaranthi tricoloris 20-25 part, Flos Inulae 8-13 part, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 8-13 part, Folium Mahoniae 13-18 part, Radix Euonymi myrianthi 20-25
Part, Lignum Aquilariae Resinatum 2.5-3.5 part, Fructus Citri 6-11 part, Herba Swertiae heteranthae 8-13 part, Radix Angelicae Pubescentis 5-8 part.
3. the pharmaceutical composition treating Meniere as claimed in claim 2, it is characterised in that by the medicine of following weight parts proportioning
Make with raw material: ear water Herba Amaranthi tricoloris 20 parts, Flos Inulae 10 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 10 parts, Folium Mahoniae 15 parts, Radix Euonymi myrianthi 22 parts, Lignum Aquilariae Resinatum 3.0
Part, Fructus Citri 8 parts, Herba Swertiae heteranthae 12 parts, Radix Angelicae Pubescentis 6 parts.
4. the pharmaceutical composition treating Meniere as claimed in claim 2, it is characterised in that by the medicine of following weight parts proportioning
Make with raw material: ear water Herba Amaranthi tricoloris 25 parts, Flos Inulae 12 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 12 parts, Folium Mahoniae 16 parts, Radix Euonymi myrianthi 24 parts, Lignum Aquilariae Resinatum 3.0
Part, Fructus Citri 8 parts, Herba Swertiae heteranthae 10 parts, Radix Angelicae Pubescentis 6 parts.
5. the pharmaceutical composition of the treatment Meniere as described in claim 1-4 is arbitrary, it is characterised in that described pharmaceutical composition can
By ear water Herba Amaranthi tricoloris, Flos Inulae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Folium Mahoniae, Radix Euonymi myrianthi, Lignum Aquilariae Resinatum, Fructus Citri, Herba Swertiae heteranthae, Radix Angelicae Pubescentis or its water or its have
Machine solvent extractable matter is active component, makes according to galenic pharmacy routine techniques.
6. the pharmaceutical composition of the treatment Meniere as described in claim 1-5 is arbitrary, it is characterised in that described pharmaceutical composition is excellent
Choosing be made for peroral dosage form, such as: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule,
Soft capsule, oral liquid, granule, electuary, pill, powder, suspensoid, powder.
7. the as claimed in claim 6 pharmaceutical composition treating Meniere, it is characterised in that described peroral dosage form be capsule,
Tablet, oral liquid, granule or pill.
8. the pharmaceutical composition treating Meniere as claimed in claim 7, it is characterised in that described peroral dosage form is capsule.
9. the pharmaceutical composition of the treatment Meniere as described in claim 1-8, it is characterised in that the preparation method of described capsule
Comprise the following steps: (1) takes Flos Inulae by prescription, Radix Angelicae Pubescentis, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Lignum Aquilariae Resinatum are pulverized, mixing, adds 3～8 times of weight portions
Concentration is alcohol reflux 1-3 time of 45%-55% (preferably 50%), and the time being every time heated to reflux is 0.5～2 hour,
Collecting filtering residue after the ethanol extraction of Flos Inulae, Radix Angelicae Pubescentis, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Lignum Aquilariae Resinatum, united extraction liquid, filter, concentrating under reduced pressure becomes thick paste；
(2) by prescription weigh ear water Herba Amaranthi tricoloris, Folium Mahoniae, Radix Euonymi myrianthi, Fructus Citri, Herba Swertiae heteranthae and Flos Inulae, Radix Angelicae Pubescentis, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw.,
Filtering residue mixing after Lignum Aquilariae Resinatum ethanol extraction, the water boiling and extraction of 4～10 times of weight portions of addition 2 times, each decocting time is 1～2
Hour, united extraction liquid, filter, stand, take supernatant, concentrating under reduced pressure becomes thick paste；
(3) thick paste mixing step (1) and step (2) obtained, is ground into the fine powder of 300-400 mesh after lyophilization,
Add relative to fine powder quality 0.05～the microcrystalline Cellulose of 0.3 times, the starch of 0.01～0.3 times, 0.005～0.05 times hard
Fatty acid magnesium, carries out mixing process, loads capsule shells and i.e. obtain Chinese medicine capsules of the present invention after sterilizing.
10. the purposes in preparation treatment Meniere medicine of the pharmaceutical composition as described in claim 1-4 is arbitrary.
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Application publication date: 20160921 |