CN105943696A - External antianxiety traditional Chinese medicine composition and preparing method thereof - Google Patents
External antianxiety traditional Chinese medicine composition and preparing method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention relates to a drug and a preparing method thereof, in particular to an external antianxiety drug and a preparing method thereof. The traditional Chinese medicine composition comprises traditional Chinese medicine extract, and the traditional Chinese medicine extract is prepared by processing, by weight, 4-8 parts of herba ecliptae, 6-12 parts of dried rehmannia root, 5-10 parts of suberect spatholobus stem, 4-10 parts of hairyvein agrimonia herb and bud, 5-8 parts of cortex albiziae, 3-9 parts of vine of multiflower knotweed, 4-8 parts of ginseng, 5-8 parts of poria with hostwood and 5-8 parts of jujube kernel. The traditional Chinese medicine composition is precise and appropriate in compatibility and has remarkable effects of calming nerves, soothing the nerves, resisting anxiety and promoting sleeping; being a drug for external use, the traditional Chinese medicine composition is free of dependency and high in safety and will not damage the body.
Description
Technical field
The present invention relates to a kind of medicine and preparation method thereof, more particularly to external medicine antianxity and preparation side thereof
Method.
Background technology
Anxiety neurosis (anxiety) is a kind of neurosis based on anxiety, is broadly divided into panic disorder with extensive
Property anxiety disorder.It is with a kind of clear and definite object and overstrain of particular content, on tenterhooks, frightened and restless or send out of lacking
The property made is the dysthymic disorder of principal character in terror, with significant autonomic nervous dysfunction's symptom, muscular tone and mobility
Uneasy.Patient is difficult to stand and cannot free, and agonizes very much.At present, clinical treatment mainly based on western medicine, but
Being that its untoward reaction is obvious, patient is difficult to accept more.During clinical treatment, first-selected Benzodiazepine medicine or antidepressants, because of benzene
Phenodiazine leather class medicine has additive, drug resistance and withdrawal symptom, the existing antidepressant of clinical often selection to have again sedation and anti-anxiety medicine many
Treatment brought under control by plug.But doxepin belongs to tricyclic antidepressant, often have excess sedation and an anticholinergic effect, performance xerostomia, constipation,
Blurred vision, there is dysuria in severe one, often affects patient compliance, therefore develop a kind of external antianxity in
Drug composition is necessary.
Summary of the invention
It is an object of the invention to solve the deficiencies in the prior art, it is provided that a kind of external anti-anxiety traditional Chinese medicine composition and system thereof
Preparation Method.
The technical solution adopted for the present invention to solve the technical problems is:
External Chinese medicine composition antianxity, described Chinese medicine composition includes Chinese medicine extract, and described Chinese medicine extract is by following
The Chinese herbal medicine of weight portion processes: Herba Ecliptae 4-8 part, raw Radix Rehmanniae Preparata 6-12 part, Caulis Spatholobi 5-10 part, and Herba Agrimoniae 4-10 part is closed
Joyous skin 5-8 part, Caulis Polygoni Multiflori 3-9 part, Radix Ginseng 4-8 part, Poria cum Radix Pini's 5-8 part, Semen Ziziphi Spinosae 5-8 part.
Preferably, described Chinese medicine extract is processed by the Chinese herbal medicine of following weight portion: Herba Ecliptae 5 parts, raw Radix Rehmanniae Preparata 8
Part, Caulis Spatholobi 6 parts, Herba Agrimoniae 6 parts, Cortex Albiziae 6 parts, Caulis Polygoni Multiflori 6 parts, Radix Ginseng 6 parts, Poria cum Radix Pini 6 parts, Semen Ziziphi Spinosae 6 parts.
Preferably, described Chinese medicine composition also includes gel auxiliary agent, and dosage form is gel.
A kind of preparation method of external Chinese medicine composition antianxity, step is as follows:
A () prepares Chinese medicine extract: the Herba Ecliptae of formula ratio, raw Radix Rehmanniae Preparata, Caulis Spatholobi, Herba Agrimoniae, Cortex Albiziae, Caulis Polygoni Multiflori, Radix Ginseng,
Poria cum Radix Pini and Semen Ziziphi Spinosae, add the ethanol water of 200-250ml volume fraction 75-85%, in 90-110 DEG C of backflow extraction 2-3 hour,
Lixiviating solution is through being concentrated in vacuo postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel auxiliary agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, then
Micro-filtration goes the removal of impurity, encapsulation；
C () Chinese medicine extract and gel auxiliary agent are with suitable ratio mix homogeneously, hybrid mode is that Chinese medicine extract becomes toward gel
Type agent is added, stirring while adding；
In described gel auxiliary agent, the mass fraction of each component is as follows: hyaluronic acid 0.2-0.3%, poloxamer 15-25%, and surplus is
Deionized water；
The proportioning of Chinese medicine extract and gel auxiliary agent is: add 20-30g Chinese medicine extract in every 120-150ml gel auxiliary agent.
Rational choice of the present invention Herba Ecliptae, raw Radix Rehmanniae Preparata, Caulis Spatholobi, Herba Agrimoniae, Cortex Albiziae, Caulis Polygoni Multiflori, Radix Ginseng, Fu Shenhe
Semen Ziziphi Spinosae, by extraction, concentrate, lyophilization obtains dry powder, prevented from caking, effective ingredient is difficult to oxidation deterioration, long shelf-life, with
Gel auxiliary agent mixes in proportion into gel, existing mixed existing use, keeps high pharmaceutically active, be coated on forehead, buccal or its
The position that its health is exposed, very easy to use, owing in gel, lock aqueous is good, the most volatile exsiccation, effective ingredient
Can the most slowly discharge, therapeutic effect is good.
The invention has the beneficial effects as follows: the Chinese medicine composition compatibility of the present invention is precise and appropriate, calm, calm the nerves, anxiety, rush are slept
Effect is notable, and the Chinese medicine composition of the present invention is medicine for external use, no dependence, and without compromising on health, safety is good.
Detailed description of the invention
Below by specific embodiment, technical scheme is described in further detail.
Embodiment 1:
External Chinese medicine composition antianxity gel, described Chinese medicine composition includes Chinese medicine extract and gel auxiliary agent, described in
Medicament extract is processed by the Chinese herbal medicine of following weight portion: Herba Ecliptae 4 parts, raw 6 parts of Radix Rehmanniae Preparata, Caulis Spatholobi 5 parts, Herba Agrimoniae 4
Part, Cortex Albiziae 5 parts, Caulis Polygoni Multiflori 3 parts, Radix Ginseng 4 parts, Poria cum Radix Pini 5 parts, Semen Ziziphi Spinosae 5 parts；
The step of its preparation method is as follows:
A () prepares Chinese medicine extract: the Herba Ecliptae of formula ratio, raw Radix Rehmanniae Preparata, Caulis Spatholobi, Herba Agrimoniae, Cortex Albiziae, Caulis Polygoni Multiflori, Radix Ginseng,
Poria cum Radix Pini and Semen Ziziphi Spinosae, add the ethanol water of 200ml volume fraction 75%, and in 90 DEG C of backflow extractions 3 hours, lixiviating solution was through vacuum
Concentrate postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel auxiliary agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, then
Micro-filtration goes the removal of impurity, encapsulation；
C () Chinese medicine extract and gel auxiliary agent are with suitable ratio mix homogeneously, hybrid mode is that Chinese medicine extract becomes toward gel
Type agent is added, stirring while adding；
In described gel auxiliary agent, the mass fraction of each component is as follows: hyaluronic acid 0.2%, poloxamer 15%, and surplus is deionization
Water；The proportioning of Chinese medicine extract and gel auxiliary agent is: add 20g Chinese medicine extract in every 120ml gel auxiliary agent.
Embodiment 2:
External Chinese medicine composition antianxity gel, described Chinese medicine composition includes Chinese medicine extract and gel auxiliary agent, described in
Medicament extract is processed by the Chinese herbal medicine of following weight portion: Herba Ecliptae 8 parts, raw 12 parts of Radix Rehmanniae Preparata, Caulis Spatholobi 10 parts, Herba Agrimoniae
10 parts, Cortex Albiziae 8 parts, Caulis Polygoni Multiflori 9 parts, Radix Ginseng 8 parts, Poria cum Radix Pini 8 parts, Semen Ziziphi Spinosae 8 parts；
The step of its preparation method is as follows:
A () prepares Chinese medicine extract: the Herba Ecliptae of formula ratio, raw Radix Rehmanniae Preparata, Caulis Spatholobi, Herba Agrimoniae, Cortex Albiziae, Caulis Polygoni Multiflori, Radix Ginseng,
Poria cum Radix Pini and Semen Ziziphi Spinosae, add the ethanol water of 250ml volume fraction 85%, and in 110 DEG C of backflow extractions 3 hours, lixiviating solution was through vacuum
Concentrate postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel auxiliary agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, then
Micro-filtration goes the removal of impurity, encapsulation；
C () Chinese medicine extract and gel auxiliary agent are with suitable ratio mix homogeneously, hybrid mode is that Chinese medicine extract becomes toward gel
Type agent is added, stirring while adding；
In described gel auxiliary agent, the mass fraction of each component is as follows: hyaluronic acid 0.3%, poloxamer 25%, and surplus is deionization
Water；The proportioning of Chinese medicine extract and gel auxiliary agent is: add 30g Chinese medicine extract in every 150ml gel auxiliary agent.
Embodiment 3
External Chinese medicine composition antianxity gel, described Chinese medicine composition includes Chinese medicine extract and gel auxiliary agent, described in
Medicament extract is processed by the Chinese herbal medicine of following weight portion: Herba Ecliptae 5 parts, raw 8 parts of Radix Rehmanniae Preparata, Caulis Spatholobi 6 parts, Herba Agrimoniae 6 parts,
Cortex Albiziae 6 parts, Caulis Polygoni Multiflori 6 parts, Radix Ginseng 6 parts, Poria cum Radix Pini 6 parts, Semen Ziziphi Spinosae 6 parts；
The step of its preparation method is as follows:
A () prepares Chinese medicine extract: the Herba Ecliptae of formula ratio, raw Radix Rehmanniae Preparata, Caulis Spatholobi, Herba Agrimoniae, Cortex Albiziae, Caulis Polygoni Multiflori, Radix Ginseng,
Poria cum Radix Pini and Semen Ziziphi Spinosae, add the ethanol water of 220ml volume fraction 80%, and in 100 DEG C of backflow extractions 2.5 hours, lixiviating solution was through true
Empty concentration postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel auxiliary agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, then
Micro-filtration goes the removal of impurity, encapsulation；
C () Chinese medicine extract and gel auxiliary agent are with suitable ratio mix homogeneously, hybrid mode is that Chinese medicine extract becomes toward gel
Type agent is added, stirring while adding；
In described gel auxiliary agent, the mass fraction of each component is as follows: hyaluronic acid 0.25%, poloxamer 20%, and surplus is deionization
Water；The proportioning of Chinese medicine extract and gel auxiliary agent is: add 25g Chinese medicine extract in every 130ml gel auxiliary agent.
The clinical trial of Chinese medicine composition of the present invention
400 example anxiety patients, meet Chinese Spirit Obstacles classification and the 3rd edition (CCMD-3) generalized anxiety disorder of diagnostic criteria
Disease diagnostic criteria, Hamilton anxiety scale (HAMA) point >=14 points；Get rid of physical disease, schizophrenia, depression
Disease.It is randomly divided into three experimental grouies (often organizing 100 examples) and matched group (100 example).Through statistical analysis, the sex between two groups, year
Age there was no significant difference, and has comparability.
Matched group patient takes doxepin, starts a 25mg according to doctor's advice, 2-3 time on the one, is gradually increased after 15 days
To a daily amount 100-250mg, continuous use 45 days.
Chinese drug-treated group patient is administered orally doxepin according to doctor's advice, a 25mg, 2 times on the one, uses embodiment 1-3 to prepare simultaneously
The Chinese medicine composition gel obtained, sleeps previous hour and is evenly applied to forehead and temple, controls after using 45 days continuously
Carry out efficacy evaluation, the results are shown in Table 1.
| Recovery from illness | Effectively | Invalid | Total effective rate | |
| Embodiment 1 | 55 | 30 | 15 | 85% |
| Embodiment 2 | 60 | 30 | 10 | 90% |
| Embodiment 3 | 75 | 20 | 5 | 95% |
| Matched group | 48 | 30 | 22 | 78% |
Above-mentioned test fully proves, compatibility of the present invention is precise and appropriate, calm, calm the nerves, effect antianxity notable, join with doxepin
Closing and use, effect is excellent, and the Chinese medicine composition of the present invention is medicine for external use, no dependence, and without compromising on health, safety is good.
Embodiment described above is the one preferably scheme of the present invention, not makees the present invention any pro forma
Limit, on the premise of without departing from the technical scheme described in claim, also have other variant and remodeling.
Claims (4)
1. external Chinese medicine composition antianxity, it is characterised in that: described Chinese medicine composition includes Chinese medicine extract, described Chinese medicine
Extract is processed by the Chinese herbal medicine of following weight portion: Herba Ecliptae 4-8 part, raw Radix Rehmanniae Preparata 6-12 part, and Caulis Spatholobi 5-10 part is celestial
Crane grass 4-10 part, Cortex Albiziae 5-8 part, Caulis Polygoni Multiflori 3-9 part, Radix Ginseng 4-8 part, Poria cum Radix Pini's 5-8 part, Semen Ziziphi Spinosae 5-8 part.
External the most according to claim 1 Chinese medicine composition antianxity, it is characterised in that: described Chinese medicine extract by under
The Chinese herbal medicine of row weight portion processes: Herba Ecliptae 5 parts, raw 8 parts of Radix Rehmanniae Preparata, Caulis Spatholobi 6 parts, Herba Agrimoniae 6 parts, and Cortex Albiziae 6 parts is first
6 parts of rattan of crow, Radix Ginseng 6 parts, Poria cum Radix Pini 6 parts, Semen Ziziphi Spinosae 6 parts.
External the most according to claim 1 and 2 Chinese medicine composition antianxity, it is characterised in that: described Chinese medicine composition
Also including gel auxiliary agent, dosage form is gel.
4. the preparation method of the external Chinese medicine composition antianxity described in a claim 3, it is characterised in that: step is such as
Under:
A () prepares Chinese medicine extract: the Herba Ecliptae of formula ratio, raw Radix Rehmanniae Preparata, Caulis Spatholobi, Herba Agrimoniae, Cortex Albiziae, Caulis Polygoni Multiflori, Radix Ginseng,
Poria cum Radix Pini and Semen Ziziphi Spinosae, add the ethanol water of 200-250ml volume fraction 75-85%, in 90-110 DEG C of backflow extraction 2-3 hour,
Lixiviating solution is through being concentrated in vacuo postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel auxiliary agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, then
Micro-filtration goes the removal of impurity, encapsulation；
C () Chinese medicine extract and gel auxiliary agent are with suitable ratio mix homogeneously, hybrid mode is that Chinese medicine extract becomes toward gel
Type agent is added, stirring while adding；
In described gel auxiliary agent, the mass fraction of each component is as follows: hyaluronic acid 0.2-0.3%, poloxamer 15-25%, and surplus is
Deionized water；
The proportioning of Chinese medicine extract and gel auxiliary agent is: add 20-30g Chinese medicine extract in every 120-150ml gel auxiliary agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610384476.9A CN105943696A (en) | 2016-06-02 | 2016-06-02 | External antianxiety traditional Chinese medicine composition and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610384476.9A CN105943696A (en) | 2016-06-02 | 2016-06-02 | External antianxiety traditional Chinese medicine composition and preparing method thereof |
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| CN105943696A true CN105943696A (en) | 2016-09-21 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1733081A (en) * | 2005-08-25 | 2006-02-15 | 贵州益佰制药股份有限公司 | Chinese medicine preparation for nourishing blood and tranquilizing mind and its preparation process |
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- 2016-06-02 CN CN201610384476.9A patent/CN105943696A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1733081A (en) * | 2005-08-25 | 2006-02-15 | 贵州益佰制药股份有限公司 | Chinese medicine preparation for nourishing blood and tranquilizing mind and its preparation process |
Non-Patent Citations (1)
| Title |
|---|
| 包祖晓等: "997首焦虑情绪治疗方剂的用药组方规律分析", 《中国中医药科技》 * |
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Application publication date: 20160921 |