CN105943686A - Pharmaceutical composition for treating pediatric balanitis - Google Patents

Pharmaceutical composition for treating pediatric balanitis Download PDF

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Publication number
CN105943686A
CN105943686A CN201610493177.9A CN201610493177A CN105943686A CN 105943686 A CN105943686 A CN 105943686A CN 201610493177 A CN201610493177 A CN 201610493177A CN 105943686 A CN105943686 A CN 105943686A
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parts
pharmaceutical composition
balanitis
children
raw material
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马健
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/78Saururaceae (Lizard's-tail family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • A61K36/195Strobilanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315Isatis, e.g. Dyer's woad
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/51Gentianaceae (Gentian family)
    • A61K36/515Gentiana
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/744Gardenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/756Phellodendron, e.g. corktree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Medicines Containing Plant Substances (AREA)

Abstract

The invention provides a pharmaceutical composition for treating pediatric balanitis. The pharmaceutical composition for treating pediatric balanitis comprises the following raw materials in parts by weight: 5 to 15 parts of coptis chinensis, 2 to 5 parts of scutellaria baicalensis, 3 to 5 parts of felwort, 4 to 8 parts of golden cypress, 1 to 5 parts of patrinia, 2 to 4 parts of cordate houttuynia, 1 to 5 parts of honeysuckle, 1 to 5 parts of dandelion, 1 to 3 parts of fructus gardenia, 1 to 3 parts of herba andrographitis and 1 to 2 parts of radix isatidis. The pharmaceutical composition provided by the invention has the advantages that the prescription is strict, drug use is reasonable, all the medicines are used together to mainly clear away heat and dry dampness, and further discharge heat and kill worms, so that damp and hot are cleared away, bloods are reconciled, detoxifying and worm killing are achieved, and the pharmaceutical composition is good and effective in curing pediatric balanitis.

Description

A kind of pharmaceutical composition treating children's's balanitis
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition treating children's's balanitis.
Background technology
Children's's balanitis refer to children's's glans part by wound, stimulate or the inflammation of mucosa that the factor such as infection causes Disease.The traditional Chinese medical science is thought, accumulates damp and hot in this sufferer body, coalesces in liver and gall two warp, bets cloudy in front and back two, sends out For foreskin reddened and swollen glans penis.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of pharmaceutical composition treating children's's balanitis, should Pharmaceutical composition good effect.
The technical scheme that the present invention provides is a kind of pharmaceutical composition treating children's's balanitis, including following The raw material of weight portion: Rhizoma Coptidis 5~15 parts, Radix Scutellariae 2~5 parts, Radix Gentianae 3~5 parts, Cortex Phellodendri 4~8 parts, Herba Patriniae 1~5 parts, Herba Houttuyniae 2~4 parts, Flos Lonicerae 1~5 parts, Herba Taraxaci 1~5 parts, Fructus Gardeniae 1~ 3 parts, Herba Andrographis 1~3 parts, Radix Isatidis 1~2 parts.
As preferably, also include Rhizoma Atractylodis 1~3 parts.
It is further preferred that also include Fructus Crataegi 1~2 parts.
Its preparation method is: by each raw material pulverizing of formula ratio, boiling, filters, filtrate is concentrated To extractum, it is dried, to obtain final product.
Further preferably, its preparation method is: by each raw material pulverizing of formula ratio, add raw material gross weight 8~ The soak by water 2 of 10 times~3 times, merge decoction liquor, filters, concentrates the filtrate to relative density when 60 DEG C It is the extractum of 1.1~1.3, is dried, to obtain final product.
Rhizoma Coptidis bitter cold, heat clearing and damp drying, Radix Scutellariae sweetness and bitterness pathogenic fire purging parasite killing, is monarch drug altogether.Radix Gentianae, Cortex Phellodendri it Bitter cold is heavy damp and hot with clear external genitals, and Herba Patriniae, Herba Houttuyniae, Flos Lonicerae, the removing toxic substances of Herba Taraxaci dampness, parasite killing is only Itch as ministerial drug.Fructus Gardeniae removing dampness and killing parasites, eliminating fire and detoxication, for adjuvant drug.Herba Andrographis, Radix Isatidis can be walked and can dissipate, Open hole powder fire is for making medicine.All medicines share, and based on heat clearing and damp drying, hold concurrently with pathogenic fire purging parasite killing, make damp and hot clearly, Blood vessels are in harmonious proportion, and poison solves worm and disappears, for treating the good recipe of children's's balanitis.On the basis of we, addition Rhizoma Atractylodis, Fructus Crataegi can strengthen the effect of heat clearing and damp drying.
Detailed description of the invention
The present invention is further elaborated for specific examples below, but not as a limitation of the invention.
Embodiment 1
Formula: Rhizoma Coptidis 5 parts, Radix Scutellariae 2 parts, Radix Gentianae 3 parts, Cortex Phellodendri 4 parts, Herba Patriniae 1 part, fish Raw meat grass 2 parts, Flos Lonicerae 1 part, Herba Taraxaci 1 part, Fructus Gardeniae 1 part, Herba Andrographis 1 part, Radix Isatidis 1 part.
Preparation method is: by each raw material pulverizing of formula ratio, adds the soak by water 2 times of raw material gross weight 8 times, Merging decoction liquor, filter, concentrating the filtrate to relative density when 60 DEG C is the extractum of 1.1, is dried, i.e. ?.
Embodiment 2
Formula: Rhizoma Coptidis 15 parts, Radix Scutellariae 5 parts, Radix Gentianae 5 parts, Cortex Phellodendri 8 parts, Herba Patriniae 5 parts, fish Raw meat grass 4 parts, Flos Lonicerae 5 parts, Herba Taraxaci 5 parts, Fructus Gardeniae 3 parts, Herba Andrographis 3 parts, Radix Isatidis 2 parts, Rhizoma Atractylodis 3 parts.
Preparation method is: by each raw material pulverizing of formula ratio, adds the soak by water 3 times of raw material gross weight 10 times, Merging decoction liquor, filter, concentrating the filtrate to relative density when 60 DEG C is the extractum of 1.3, is dried, i.e. ?.
Embodiment 3
Formula: Rhizoma Coptidis 5 parts, Radix Scutellariae 5 parts, Radix Gentianae 3 parts, Cortex Phellodendri 8 parts, Herba Patriniae 1 part, fish Raw meat grass 4 parts, Flos Lonicerae 1 part, Herba Taraxaci 5 parts, Fructus Gardeniae 1 part, Herba Andrographis 3 parts, Radix Isatidis 1 part, Rhizoma Atractylodis 3 parts, Fructus Crataegi 1 part.
Preparation method is: by each raw material pulverizing of formula ratio, adds the soak by water 3 times of raw material gross weight 8 times, Merging decoction liquor, filter, concentrating the filtrate to relative density when 60 DEG C is the extractum of 1.1, is dried, i.e. ?.
Embodiment 4
Formula: Rhizoma Coptidis 15 parts, Radix Scutellariae 2 parts, Radix Gentianae 5 parts, Cortex Phellodendri 4 parts, Herba Patriniae 5 parts, fish Raw meat grass 2 parts, Flos Lonicerae 5 parts, Herba Taraxaci 1 part, Fructus Gardeniae 3 parts, Herba Andrographis 1 part, Radix Isatidis 2 parts, Rhizoma Atractylodis 1 part, Fructus Crataegi 2 parts.
Preparation method is: by each raw material pulverizing of formula ratio, adds the soak by water 2 times of raw material gross weight 9 times, Merging decoction liquor, filter, concentrating the filtrate to relative density when 60 DEG C is the extractum of 1.2, is dried, i.e. ?.
By following clinical trial checking beneficial effects of the present invention:
1, clinic case
Choose children's's glans penis inflammation clinical case 250 example, the age between 4~12 years old, the course of disease 3 days~1 Year, it is randomly divided into 5 groups, respectively experimental group 1~4 and matched group, often organizes 50 people.
2, diagnostic criteria
With reference to " clinical dermatology ", all have phimosis, redundant prepuce, erythema at penis foreskin, pimple, Rotten to the corn, covering white cheese sample film, accompanies pruritus.Infusorian, spore, mycelia etc. seen from secretions microscopy.
3, administrated method
Experimental group 1~4 uses the pharmaceutical composition of embodiment 1~4 to carry out washout treatment respectively, makes every time With being equivalent to crude drug 1g, every day 1 time.It within one week, it is a course for the treatment of.
Matched group uses by Radix Sophorae Flavescentis 60g, Fructus Cnidii 30g, Fructus Kochiae 30g, Herba Houttuyniae 30g, Cortex Dictamni The pharmaceutical composition of 30g, Flos Chrysanthemi Indici 30g preparation carries out washout treatment, and each 1 time, 1 consumption is 210g Crude drug.It within one week, it is a course for the treatment of.
4, curative effect determinate standard:
Recovery from illness: glans penis inflammation disappears, no longer pruritus;
Effective: glans penis inflammation significantly reduces, pruritis improves;
Invalid: inflammation and other symptoms are the most unchanged.
5, experimental result
Group Cure Effectively Invalid Total effective rate
Experimental group 1 28 18 4 92
Experimental group 2 30 17 3 94
Experimental group 3 32 16 2 96
Experimental group 4 29 20 1 98
Matched group 5 25 20 60
Note: compared with matched group, * P < 0.05, * * P < 0.01.
To treatment Patients Before And After routine blood test, liver function, renal function and the detection of routine urinalysis, no abnormality seen.

Claims (5)

1. the pharmaceutical composition treating children's's balanitis, it is characterised in that: include following weight Part raw material: Rhizoma Coptidis 5~15 parts, Radix Scutellariae 2~5 parts, Radix Gentianae 3~5 parts, Cortex Phellodendri 4~8 parts, Herba Patriniae 1~5 parts, Herba Houttuyniae 2~4 parts, Flos Lonicerae 1~5 parts, Herba Taraxaci 1~5 parts, Fructus Gardeniae 1~3 part, Herba Andrographis 1~3 parts, Radix Isatidis 1~2 parts.
The pharmaceutical composition for the treatment of children's's balanitis the most according to claim 1, its feature exists In: also include Rhizoma Atractylodis 1~3 parts.
The pharmaceutical composition for the treatment of children's's balanitis the most according to claim 1, its feature exists In: also include Fructus Crataegi 1~2 parts.
The pharmaceutical composition for the treatment of children's's balanitis the most according to claim 1, its feature exists In: its preparation method is: by each raw material pulverizing of formula ratio, boiling, filter, and filtrate is dense It is reduced to extractum, is dried, to obtain final product.
The pharmaceutical composition for the treatment of children's's balanitis the most according to claim 4, its feature It is: its preparation method is: by each raw material pulverizing of formula ratio, adds raw material gross weight 8~10 times Soak by water 2~3 times, merge decoction liquor, filters, concentrate the filtrate to relative density when 60 DEG C be 1.1~ The extractum of 1.3, is dried, to obtain final product.
CN201610493177.9A 2016-06-27 2016-06-27 Pharmaceutical composition for treating pediatric balanitis Pending CN105943686A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102114216A (en) * 2010-12-03 2011-07-06 郑延明 Externally applied antibacterial and antiphlogistic medicament and preparation method thereof
CN103721139A (en) * 2013-12-30 2014-04-16 青岛恒波仪器有限公司 Traditional Chinese medicinal composition for treating balanitis and preparation method thereof
CN104825952A (en) * 2015-05-30 2015-08-12 王淑英 Traditional Chinese medicine for treating balanoposthitis
CN105362522A (en) * 2015-11-28 2016-03-02 谭海韵 Oral drug specially for treating male balanitis and preparation method thereof
CN105381353A (en) * 2015-11-28 2016-03-09 谭海韵 External preparation for preventing male wrapping balanitis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102114216A (en) * 2010-12-03 2011-07-06 郑延明 Externally applied antibacterial and antiphlogistic medicament and preparation method thereof
CN103721139A (en) * 2013-12-30 2014-04-16 青岛恒波仪器有限公司 Traditional Chinese medicinal composition for treating balanitis and preparation method thereof
CN104825952A (en) * 2015-05-30 2015-08-12 王淑英 Traditional Chinese medicine for treating balanoposthitis
CN105362522A (en) * 2015-11-28 2016-03-02 谭海韵 Oral drug specially for treating male balanitis and preparation method thereof
CN105381353A (en) * 2015-11-28 2016-03-09 谭海韵 External preparation for preventing male wrapping balanitis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
刘明军: ""中药煎剂治疗真菌性包皮龟头炎26例"", 《黑龙江医药科学》 *

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