CN105943586A - Sambucus adnata hard ointment capable of diminishing inflammation and relieving pain and preparation method thereof - Google Patents
Sambucus adnata hard ointment capable of diminishing inflammation and relieving pain and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a sambucus adnata hard ointment capable of diminishing inflammation and relieving pain and a preparation method thereof, and relates to the technical field of application of natural plant extract in the field of medicine. The sambucus adnata hard ointment capable of diminishing inflammation and relieving pain is prepared from, by mass, 1-30% of sambucus adnata extract, 1-30% of fatty acid alkali metal salt, 10-80% of monohydric alcohol, 0.5-50% of polyhydric alcohol, 2-10% of an auxiliary material and 15-40% of aids. The hard ointment is mainly used for treating traumatic injuries, sprains and mild water or fire scalds, is definite in treatment effect, prolongs the action time of active ingredients on affected parts and increases the utilization rate of active ingredients on affected parts, and the action effect of medicine is enhanced; besides, the preparation method of the hard ointment is simple and has the advantages that temperature control is easy, grinding is not needed, the character is good and preparation is easy, and the preparation method is especially suitable for large-scale industrial production.
Description
Technical field
The present invention relates to the applied technical field relating to natural plant extracts on field of medicaments,
It is specifically related to a kind of Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment machin its preparation method.
Background technology
At present, clinically for osteopatia sprain, myalgia, arthralgia, fracture pain etc.
The widely used anti-inflammatory analgetic class medicine of illness generally can be divided into oral and exterior-applied formulation.Common
Exterior-applied formulation have ointment, liniment and patch etc., it should be noted that when externally applied anti-inflammation pain relieving
When the viscosity of gel (thickening agent) is discontented with 5000cps, its painting to disease pars affecta skin
Applying effect undesirable, viscosity surmounts 35000cps and should not use again, and interfacial tension is less than 5dyn/cm2
Time coagulant liquid can flow out flush coat.Additionally, for ointment, the tactile ointment that needs to catch exists
Affected part is coated with, but smears ointment with hands and medicine may touch eye and other mucosal sites
And danger occurs.Therefore it provides one is directly touched without hands, for osteopatia sprain, muscle
The illness such as pain, arthralgia, fracture pain have safely and effectively, and can be directly coated with and
Anti-inflammatory analgetic hard ointment easy to use has the biggest market demand undoubtedly.From this
Angle consider, hard ointment use with carry relative convenient.Especially illness dispose time,
Hard ointment more shows that on the Clinical practice of anti-inflammatory analgetic it is safely, effectively and easy to use
On advantage.
Herba Sambuci Adnatae, has blood-activating and qi-promoting, eliminating blood stasis and smoothing collaterals, numbness relieving and pain relieving, effect.Due to tradition
External Herba Sambuci Adnatae preparation be Herba Sambuci Adnatae medicated wine liniment be the traditional Herba Sambuci Adnatae extract of liquid be a kind of
Externally-applied liniment, is in a liquid state, and its viscosity is low, mobility is big, the time of staying is short, not only affects
The performance of curative effect, and it is not easy to storage transport, and there is easy pollution clothes and carry use not side
The defect such as just.In order to inherit and excavate the use value of traditional Chinese patent medicine Herba Sambuci Adnatae extract, increase
The action effect of strong medicine, it is therefore necessary to former dosage form and preparation method are improved.
Therefore it provides one is for osteopatia sprain, myalgia, arthralgia, fracture pain
Have safely and effectively etc. illness, and directly touch with hands and can be directly coated with and blood easy to use
Full grass anti-inflammatory analgetic hard ointment has application market widely.
Summary of the invention
For the deficiencies in the prior art, the invention provides a kind of is effective with Herba Sambuci Adnatae extract
The hard ointment of composition, it has detumescence dissipating blood stasis, effect of relaxing muscles and tendons and activating QI and blood in the collateral pain relieving, overcomes existing
Have technology Chinese medicinal ointment in-convenience in use etc. defect, strengthen drug effectiveness.
For realizing object above, the present invention is achieved by the following technical programs:
A kind of Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, composed of the following components by mass fraction: blood
Full grass extract 1～30%, fatty acid alkali metal salt 1～30%, monohydric alcohol 10～80%, polyhydric alcohol
0.5～50%, adjuvant 2～10%, auxiliary agent 15～40%；
Described adjuvant is the extract of Camphora or Herba Menthae.
Preferably, described Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, by mass fraction by following components
Composition: Herba Sambuci Adnatae extract 1～30%, fatty acid alkali metal salt 2～25%, monohydric alcohol 30～75%,
Polyhydric alcohol 0.5～50%, adjuvant 2～10%, auxiliary agent 15～40%.
Preferably, described Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, by mass fraction by following components
Composition: Herba Sambuci Adnatae extract 1～30%, fatty acid alkali metal salt 4～15%, monohydric alcohol 50～70%,
Polyhydric alcohol 0.5～50%, adjuvant 2～10%, auxiliary agent 15～40%.
Preferably, described fatty acid alkali metal salt is capric acid, myristic acid, Palmic acid, firmly
Fat acid, oleic acid, 9-undecylenic acid, linoleic acid, at least in the alkali metal salt of linolenic acid etc.
Kind.
Preferably, during described monohydric alcohol is the monohydric alcohol of carbon atom quantity 6 or less than 6
At least one.
Preferably, described auxiliary agent is hard ester group polydimethylsiloxane, the different tristearin of tetramethylolmethane four
At least one in acid esters, tridecyl alcohol trimellitate, synthesis squalane and vaseline.
The preparation method of a kind of Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, comprises the following steps:
(1) go root to pulverize Herba Sambuci Adnatae, by solvent to Herba Sambuci Adnatae to extracting, obtain blood
Full grass extract, described solvent is the mixture of water, ethanol or water and ethanol, and Herba Sambuci Adnatae with
The mass ratio of solvent is 1:5～10, and the extracting method of described employing Herba Sambuci Adnatae extract is solvent temperature
Leaching method, heating reflux method, ultrasonic extraction or microwave loss mechanisms；
(2), after auxiliary agent being mixed homogeneously with fatty acid alkali metal salt, it is warming up to 50～80 DEG C, adds
Enter monohydric alcohol and polyhydric alcohol, after being stirred continuously uniformly, obtain ointment base；
(3) Herba Sambuci Adnatae extract and adjuvant are disperseed dilution, be subsequently adding and be cooled to 38～40 DEG C
Ointment base in, and be constantly slowly stirred, be cooled to room temperature to hard ointment, obtain blood full
Grass anti-inflammatory analgetic hard ointment.
Preferably, the compressed value of described hard ointment is being 300～4000gf/cm2, fusing point is
30～80 DEG C.
Preferably, the compressed value of described hard ointment is being 500～3000gf/cm2, fusing point is
45-75℃。
Beneficial effects of the present invention: the invention provides a kind of with Herba Sambuci Adnatae extract for main one-tenth
Point hard ointment, which increase effective ingredient in action time at illness position and utilization rate,
Overcome former dosage form in-convenience in use etc. defect, enhance the action effect of medicine；The present invention's is hard
Matter ointment can also avoid the direct contact of hands, and be prevented from hands and touch after ointment eye
And the harm of other mucosal sites, experiment proves that Herba Sambuci Adnatae extract ointment can be effectively improved painting
Smear the ear edge swelling caused by Oleum Tiglii, and there is no obvious toxic and side effects；In the present invention, blood is full
The preparation method of grass hard ointment is simple, has temperature and controls easily, it is not necessary to grinds, character is good,
The advantages such as preparation is simple.The Herba Sambuci Adnatae hard ointment of the present invention has detumescence dissipating blood stasis, relaxing muscles and tendons and activating QI and blood in the collateral
Analgesic effect, is mainly used in treating traumatic injury, sprains, slight burn due to hot liquid or fire, and it also has
Determined curative effect, the feature such as safe and convenient to use, and preparation method are simple, are suitable for industrial-scale
Produce.
Detailed description of the invention
For making the purpose of the embodiment of the present invention, technical scheme and advantage clearer, below will knot
Close the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely retouched
State, it is clear that described embodiment is a part of embodiment of the present invention rather than whole realities
Execute example.Based on the embodiment in the present invention, those of ordinary skill in the art are not making creation
The every other embodiment obtained under property work premise, broadly falls into the scope of protection of the invention.
The present invention is to 10mm (thick) × 10mm (diameter) by electronic type compressive strength tester
Sample detects the compressed value of sample ointment under the conditions of 25 DEG C.Attached according to Chinese Pharmacopoeia version in 2015
The fusing point of record-melting point determination test ointment.
Embodiment 1:
A kind of Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, composed of the following components by mass fraction: blood
Full grass extract 1%, potassium myristate 1.5%, ethanol 80%, Polyethylene Glycol 0.5%, Camphora
Extract 2%, hard ester group polydimethylsiloxane 10%, pentaerythritol tetraoctyl stearate 5%.
The preparation method of described Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, comprises the following steps:
(1) go root to pulverize Herba Sambuci Adnatae, add in the ethanol solution of 5 times amount, be heated to reflux
To Herba Sambuci Adnatae extract；
(2) by hard ester group polydimethylsiloxane, pentaerythritol tetraoctyl stearate and Semen Myristicae
After acid potassium mix homogeneously, it is warming up to 50 DEG C, adds ethanol and Polyethylene Glycol, be stirred continuously uniformly
After obtain ointment base；
(3) Herba Sambuci Adnatae extract and Chinese medicine extract are disperseed dilution, be subsequently adding and be cooled to
In the ointment base of 38～40 DEG C, and constantly it is slowly stirred, is cooled to room temperature to hard ointment,
To Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment.
The compressed value of the present embodiment is 300gf/cm2, fusing point is 30 DEG C.
Embodiment 2:
A kind of Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, composed of the following components by mass fraction: blood
Full grass extract 1%, sodium palmitate 10%, sodium stearate 20%, methanol 30%, propylene glycol
0.5%, Camphora extract 2%, synthesis squalane 20%, vaseline 17.5%；
The preparation method of described Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, comprises the following steps:
(1) go root to pulverize Herba Sambuci Adnatae, add in the aqueous solution of 10 times amount, pass through ultrasound wave
Method extracts Herba Sambuci Adnatae extract；
(2) after synthesis squalane and vaseline being mixed homogeneously with sodium palmitate, sodium stearate,
It is warming up to 60 DEG C, adds methanol and propylene glycol, after being stirred continuously uniformly, obtain ointment base；
(3) Herba Sambuci Adnatae extract and Chinese medicine extract are disperseed dilution, be subsequently adding and be cooled to
In the ointment base of 38～40 DEG C, and constantly it is slowly stirred, is cooled to room temperature to hard ointment,
To Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment.
The compressed value of the present embodiment is 4000gf/cm2, fusing point is 80 DEG C.
Embodiment 3:
A kind of Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, composed of the following components by mass fraction: blood
Full grass extract 2%, linoleic acid sodium 10%, capric acid 5%, isopropanol 50%, glycerol 10%,
Folium Menthae extract 3%, tridecyl alcohol trimellitate 5%, vaseline 15%.
The preparation method of described Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, comprises the following steps:
(1) go root to pulverize Herba Sambuci Adnatae, add in the water of 8 times amount and the mixed solution of ethanol,
Herba Sambuci Adnatae extract is extracted by solvent warm macerating method；
(2), after tridecyl alcohol trimellitate and vaseline being mixed homogeneously with linoleic acid sodium, rise
Temperature, to 70 DEG C, adds isopropanol and glycerol, obtains ointment base after being stirred continuously uniformly；
(3) Herba Sambuci Adnatae extract and Chinese medicine extract are disperseed dilution, be subsequently adding and be cooled to
In the ointment base of 38～40 DEG C, and constantly it is slowly stirred, is cooled to room temperature to hard ointment,
To Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment.
The compressed value of the present embodiment is 3826gf/cm2, fusing point is 75 DEG C.
Embodiment 4:
A kind of Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, composed of the following components by mass fraction: blood
Full grass extract 5%, linolenic acid sodium 1%, ethanol 50%, methanol 25%, propylene glycol 1%,
Folium Menthae extract 3%, vaseline 15%.
The preparation method of described Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, comprises the following steps:
(1) go root to pulverize Herba Sambuci Adnatae, add in the water of 8 times amount and the mixed solution of ethanol,
By supercritical ultrasonics technology to extracting Herba Sambuci Adnatae extract；
(2), after being mixed homogeneously with linoleic acid sodium, linolenic acid sodium by vaseline, it is warming up to 60 DEG C,
Add ethanol, methanol and propylene glycol, after being stirred continuously uniformly, obtain ointment base；
(3) Herba Sambuci Adnatae extract and Chinese medicine extract are disperseed dilution, be subsequently adding and be cooled to
In the ointment base of 38～40 DEG C, and constantly it is slowly stirred, is cooled to room temperature to hard ointment,
To Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment.
The compressed value of the present embodiment is 3200gf/cm2, fusing point is 70 DEG C.
Embodiment 5:
A kind of Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, composed of the following components by mass fraction: blood
Full grass extract 5%, linolenic acid sodium 2%, n-butyl alcohol 70%, polyhydric alcohol 5%, Folium Menthae extract
3%, synthesis squalane 5%, vaseline 10%.
The preparation method of described Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, comprises the following steps:
(1) go root to pulverize Herba Sambuci Adnatae, add in the water of 8 times amount and the mixed solution of ethanol,
By microwave ripple method to extracting Herba Sambuci Adnatae extract；
(2), after synthesis squalane and vaseline being mixed homogeneously with linolenic acid sodium, it is warming up to 70 DEG C,
Add methanol and propylene glycol, after being stirred continuously uniformly, obtain ointment base；
(3) Herba Sambuci Adnatae extract and Chinese medicine extract are disperseed dilution, be subsequently adding and be cooled to
In the ointment base of 38～40 DEG C, and constantly it is slowly stirred, is cooled to room temperature to hard ointment,
To Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment.
The compressed value of the present embodiment is 500gf/cm2, fusing point is 45 DEG C.
Embodiment 6:
A kind of Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, composed of the following components by mass fraction: blood
Full grass extract 10%, potassium stearate 2%, potassium oleate 8%, 2-amylalcohol 20%, glycerol 20%,
Camphora extract 5%, hard ester group polydimethylsiloxane 20%, synthesis squalane 20%.
The preparation method of described Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, comprises the following steps:
(1) go root to pulverize Herba Sambuci Adnatae, add in the water of 8 times amount and the mixed solution of ethanol,
By microwave ripple method to extracting Herba Sambuci Adnatae extract；
(2) by hard ester group polydimethylsiloxane and synthesis squalane and potassium stearate, potassium oleate
After mix homogeneously, it is warming up to 70 DEG C, adds 2-amylalcohol and glycerol, after being stirred continuously uniformly
To ointment base；
(3) Herba Sambuci Adnatae extract and Chinese medicine extract are disperseed dilution, be subsequently adding and be cooled to
In the ointment base of 38～40 DEG C, and constantly it is slowly stirred, is cooled to room temperature to hard ointment,
To Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment.
The compressed value of the present embodiment is 638gf/cm2, fusing point is 61 DEG C.
Embodiment 7:
A kind of Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, composed of the following components by mass fraction: blood
Full grass extract 11%, sodium palmitate 4%, methanol 5%, ethanol 5%, polyhydric alcohol 50%,
Camphora extract 10%, hard ester group polydimethylsiloxane 15%.
The preparation method of described Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, comprises the following steps:
(1) go root to pulverize Herba Sambuci Adnatae, add in the ethanol solution of 5 times amount, by heating back
Flow extracting Herba Sambuci Adnatae extract；
(2), after hard ester group polydimethylsiloxane being mixed homogeneously with sodium palmitate, it is warming up to
80 DEG C, add methanol and propylene glycol, after being stirred continuously uniformly, obtain ointment base；
(3) Herba Sambuci Adnatae extract and Chinese medicine extract are disperseed dilution, be subsequently adding and be cooled to
In the ointment base of 38～40 DEG C, and constantly it is slowly stirred, is cooled to room temperature to hard ointment,
To Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment.
The compressed value of the present embodiment is 1038gf/cm2, fusing point is 78 DEG C.
Embodiment 8:
A kind of Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, composed of the following components by mass fraction: blood
Full grass extract 30%, sodium stearate 25%, isobutanol 10%, glycerol 7%, Herba Menthae are extracted
Thing 10%, tridecyl alcohol trimellitate 18%.
The preparation method of described Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, comprises the following steps:
(1) go root to pulverize Herba Sambuci Adnatae, add in the ethanol solution of 5 times amount, by heating back
Flow extracting Herba Sambuci Adnatae extract；
(2), after being mixed homogeneously with sodium stearate by tridecyl alcohol trimellitate, it is warming up to 80 DEG C,
Add isobutanol and glycerol, after being stirred continuously uniformly, obtain ointment base；
(3) Herba Sambuci Adnatae extract and Chinese medicine extract are disperseed dilution, be subsequently adding and be cooled to
In the ointment base of 38～40 DEG C, and constantly it is slowly stirred, is cooled to room temperature to hard ointment,
To Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment.
The compressed value of the present embodiment is 3000gf/cm2, fusing point is 69 DEG C.
The study of pharmacy of Herba Sambuci Adnatae extract hard ointment of the present invention
The Herba Sambuci Adnatae extract hard ointment of the present invention therapeutical effect to ear swelling caused by Oleum Tiglii
1, animal model: experiment uses male 7 week old Kunming mouses, purchased from Yunnan Province's medical science
Experimental Animal Center, rearing conditions: 23 ± 2 DEG C, humidity 55 ± 5%, rate of ventilation 12-15
Secondary/hour, lighting hours 12h/d (7:00～19:00 turns on light), 5/rearging cage (235 × 325
× 170H mm), Rearing Condition: solid feed, freely drink water, raise one week.Choose body
Heavily etc. there was no significant difference, mice 40 that growth conditions is good is only tested.
2, it is grouped and is administered: choosing the mice that body weight etc. there was no significant difference, growth conditions is good
40, it is divided into matched group, A group, B group and C group, often group 10.Each group at Oleum Tiglii
Following medicine is given respectively: matched group: do not smear medicine after reason mice；A group: compound recipe
Dexamethasone acetate ointment (traditional Chinese medicines quasi-word H44024717)；B group: smear Herba Sambuci Adnatae and extract
Thing；C group: Herba Sambuci Adnatae extract hard ointment.
3, method of testing:
(1) first 3% Oleum Tiglii is spread upon each group little according to 25 μ L every ear dose uniformity
Mus auris dextra edge middle body, after smearing 5min, respectively to A group, B group, C group mouse ear edge
Tested material is smeared in portion, presses 0.1mL 10g-1 body weight dose to each group of mouse tail vein injection after 3h
1% Ai Wensilan normal saline solution, after injection Ai Wensilan normal saline 1h, with diameter 8
Mm card punch takes off two ears；
(2) ear tissue sheet is put in 1mL 1M KOH aqueous solution, at 37 DEG C, soak 24
H, is subsequently adding 9mL 0.6M phosphoric acid-acetone (5:13) solution, at 3000r after being sufficiently stirred for
min-1Under be centrifuged 15min, take supernatant；
(3) supernatant is placed under 620nm wavelength and measures its absorbance, calculate Ai Wensilan
Amount, and as vascular permeability index, analyze and judge edema situation.
Experimental data represents with Mean ± SD, and application SPSS 19.0 software is carried out at data
Reason, meets normal distribution and the neat data of variance carry out one factor analysis of variance；Heterogeneity of variance
Data then use non parametric tests, and p < 0.05 is statistically significant.
Table 1: the Herba Sambuci Adnatae extract hard ointment impact on ear swelling caused by Oleum Tiglii
Test result indicate that Herba Sambuci Adnatae extract ointment can be effectively improved to smear caused by Oleum Tiglii
Ear edge swelling.
To sum up, the embodiment of the present invention has the advantages that the Herba Sambuci Adnatae hard of the present invention is soft
Cream has detumescence dissipating blood stasis, relaxing muscles and tendons and activating QI and blood in the collateral analgesic effect, is mainly used in treating traumatic injury, sprains,
Slight burn due to hot liquid or fire, the features such as it also has a determined curative effect, safe and convenient to use, and preparation side
Method is simple, is suitable for industrial mass production.
It should be noted that in this article, the relational terms of such as first and second or the like is only
Only it is used for separating an entity or operation with another entity or operating space, and not necessarily
Require or imply and there is the relation of any this reality or suitable between these entities or operation
Sequence.And, term " includes ", " comprising " or its any other variant are intended to nonexcludability
Comprise, so that include the process of a series of key element, method, article or equipment not only
Including those key elements, but also include other key elements being not expressly set out, or also include
The key element intrinsic for this process, method, article or equipment.There is no more restriction
In the case of, statement " including ... " key element limited, it is not excluded that including described wanting
Process, method, article or the equipment of element there is also other identical element.
Above example only in order to technical scheme to be described, is not intended to limit；Although
With reference to previous embodiment, the present invention is described in detail, those of ordinary skill in the art
It is understood that the technical scheme described in foregoing embodiments still can be modified by it,
Or wherein portion of techniques feature is carried out equivalent；And these amendments or replacement, not
The essence making appropriate technical solution departs from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (9)
1. a Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, it is characterised in that by mass fraction by with
Lower component forms: Herba Sambuci Adnatae extract 1～30%, fatty acid alkali metal salt 1～30%, monohydric alcohol
10～80%, polyhydric alcohol 0.5～50%, adjuvant 2～10%, auxiliary agent 15～40%；
Described adjuvant is the extract of Camphora or Herba Menthae.
2. Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment as claimed in claim 1, it is characterised in that
Composed of the following components by mass fraction: Herba Sambuci Adnatae extract 1～30%, fatty acid alkali metal salt
2～25%, monohydric alcohol 30～75%, polyhydric alcohol 0.5～50%, adjuvant 2～10%, auxiliary agent 15～40%.
3. Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment as claimed in claim 2, it is characterised in that
Composed of the following components by mass fraction: described Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment, by weight
Meter, is made up of following material: Herba Sambuci Adnatae extract 1～30%, fatty acid alkali metal salt 4～15%,
Monohydric alcohol 50～70%, polyhydric alcohol 0.5～50%, adjuvant 2～10%, auxiliary agent 15～40%.
4. Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment as claimed in claim 3, it is characterised in that
Described fatty acid alkali metal salt is capric acid, myristic acid, Palmic acid, stearic acid, oleic acid,
9-undecylenic acid, linoleic acid, at least one in the alkali metal salt of linolenic acid etc..
5. Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment as claimed in claim 4, it is characterised in that
Described monohydric alcohol is at least one in the monohydric alcohol of carbon atom quantity 6 or less than 6.
6. Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment as claimed in claim 5, it is characterised in that
Described auxiliary agent is hard ester group polydimethylsiloxane, pentaerythritol tetraoctyl stearate, tridecane
At least one in alcohol trimellitate, synthesis squalane and vaseline.
7. Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment as claimed in claim 6, it is characterised in that
The compressed value of described hard ointment is being 300～4000gf/cm2, fusing point is 30～80 DEG C.
8. Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment as claimed in claim 7, it is characterised in that
The compressed value of described hard ointment is being 500～3000gf/cm2, fusing point is 45-75 DEG C.
9. the preparation side of the Herba Sambuci Adnatae anti-inflammatory analgetic hard ointment as described in as arbitrary in claim 1～8
Method, it is characterised in that comprise the following steps:
(1) go root to pulverize Herba Sambuci Adnatae, by solvent to Herba Sambuci Adnatae to extracting, obtain blood
Full grass extract, described solvent is the mixture of water, ethanol or water and ethanol, and Herba Sambuci Adnatae with
The mass ratio of solvent is 1:5～10, and the extracting method of described employing Herba Sambuci Adnatae extract is solvent temperature
Leaching method, heating reflux method, ultrasonic extraction or microwave loss mechanisms；
(2), after auxiliary agent being mixed homogeneously with fatty acid alkali metal salt, it is warming up to 50～80 DEG C, adds
Enter monohydric alcohol and polyhydric alcohol, after being stirred continuously uniformly, obtain ointment base；
(3) Herba Sambuci Adnatae extract and adjuvant are disperseed dilution, be subsequently adding and be cooled to 38～40 DEG C
Ointment base in, and be constantly slowly stirred, be cooled to room temperature to hard ointment, obtain blood full
Grass anti-inflammatory analgetic hard ointment.
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| CN201610422056.5A CN105943586A (en) | 2016-06-15 | 2016-06-15 | Sambucus adnata hard ointment capable of diminishing inflammation and relieving pain and preparation method thereof |
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| CN108771753B (en) * | 2018-07-04 | 2021-08-13 | 广州白云山敬修堂药业股份有限公司 | Traumatic injury kaleidoscope oil hard ointment and preparation method thereof |
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