CN105943071A - X-ray ct imaging system - Google Patents
X-ray ct imaging system Download PDFInfo
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- CN105943071A CN105943071A CN201610352174.3A CN201610352174A CN105943071A CN 105943071 A CN105943071 A CN 105943071A CN 201610352174 A CN201610352174 A CN 201610352174A CN 105943071 A CN105943071 A CN 105943071A
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Abstract
Provided is an X-ray CT imaging system, relating to X-ray imaging. The X-ray CT imaging system is provided with a PC end, a high-voltage generator, an X-ray bulb tube, a servo system and an X-ray detector. The PC end is connected to one end of the high-voltage generator and the other end of the high-voltage generator is connected with the X-ray bulb tube. The servo system is provided with a three-axis servo motion platform and a three-axis servo controller. The three-axis servo motion platform is provided with an elevating table, a translation table and an object-carrying table. One end of the three-axis servo controller is connected with the PC end. The three-axis servo controller is used for controlling motion of the three-axis servo motion platform. The X-ray detector is fixed on the elevating table. The elevating table is fixed on the translational table and moves with the translational table. The X-ray detector is used for collecting signals and transmitting singles to the PC end. A sample to be detected is placed on the object-carrying table and rotates with the object-carrying table. The PC end is used for sampling semi-circumference of cone beams for data collected by the detector and calculating by adoption of a 3D reconstruction algorithm so that a CT image of the sample to be detected can be obtained and the image is high in resolution and good in contrast ratio.
Description
Technical field
The present invention relates to x-ray imaging, especially relate to a kind of low cost X ray CT imaging system.
Background technology
X-ray imaging system in current biomedicine is mainly DR imaging system and CT imaging system, and DR imaging is to generate two dimension
Figure, CT imaging is to generate three-dimensional graph.Utilize X ray CT imaging technique and system as the means of a kind of pattern imaging,
It plays very important effect to the diagnosis of some biomedical diseases.
Chinese patent CN 104545963 A discloses adjacent pair of x-ray source CT imaging system and application thereof, and this system includes X-ray
Source and detector;Described X source is adjacent pair of X source, and described adjacent pair of X source is just oppositely arranged with described detector;Institute
The photon doses stating adjacent pair of X source transmitting is identical;Described adjacent pair of X source is parallel to Plane of rotation.
Summary of the invention
It is an object of the invention to provide the X ray CT imaging system of a kind of high and low cost of CT image resolution ratio.
The present invention is provided with PC end, high tension generator, X-ray bulb, servosystem, X-ray detector;PC end occurs with high pressure
One end of device is connected, and the other end of high tension generator is connected with X-ray bulb, X-ray bulb send X-ray;Servosystem sets
Three axle servo motion platforms and three axle servo controllers, three axle servo motion platforms are had to be provided with lifting platform, translation stage and object stage,
One end of three axle servo controllers is connected with PC end, and three axle servo controllers control the motion of three axle servo motion platforms;X-ray is visited
Surveying device to be fixed on lifting platform, lifting platform is fixed on translation stage, and lifting platform is followed translation stage and moved together;X-ray detector pair
Signal is acquired, and signal is transmitted back to PC end, and sample is placed on object stage, follows object stage rotary motion together;
The data that detector is collected by PC end carry out cone beam semi-circumference sampling CT three-dimensional reconstruction algorithm and calculate, available sample
CT image, and the resolution of CT image is high, good contrast.
Described X-ray detector can use single/few pixel x-ray detector, single/few pixel x-ray detector to use 16 pixels
Battle array, the most single-row 16 equally distributed forms of pixel are laid out, and the concept of single/few pixel is the most here.Single/few pixel x-ray is visited
Survey device is followed lifting platform and is moved together with translation stage, can carry out two-dimensional scan, collect abundant throwing in large-area scope
Shadow information and dot matrix signal, it is possible to achieve low cost, high-resolution CT imaging.
Described list/few pixel x-ray detector includes sensor and data acquiring control circuit two parts.
Described sensor can use 16 elemental silicon photodiodes that Bin Song group of Japan manufactures as sensor, by sensing difference
X-ray intensity converts optical signals to the signal of telecommunication, and model is S5668-121.Although simple silicon photoelectric diode wavelength response model
It is trapped among outside X-ray wavelength, but this 16 elemental silicon photodiode is combined with CsI (TI) scintillator, it becomes possible to use
In X-ray detection and CT imaging.
Described data acquiring control circuit can use STM32F407 that ST STMicw Electronics produces as microcontroller, with ADI
The AD conversion chip that Ya De promise produces is successively read S5668-121 as AD analog-digital converter, the FSMC interface utilizing MCU to carry
The 16 element detection point signals that silicon photoelectric diode sensor is changed out, and sent in real time to PC end by RS-232 serial line interface,
Use for follow-up CT three-dimensional reconstruction algorithm.
Described list/few pixel x-ray detector software algorithm part mainly includes that the FSMC that AD conversion chip initializes with MCU connects
Mouth initializes two parts.The parameters such as the sample frequency of AD conversion chip, over-sampling multiple, sampled signal input range are set by MCU
After reserving, it is possible to start AD conversion chip and sensor output signal is sampled and changes.The FSMC that it is carried by MCU
Interface sets the parameters such as address foundation, retention time, data setup time, clock division coefficient, FSMC access module respectively
After, it is possible to the data after using FSMC interface fast and stable to read AD conversion chip conversion, and send via RS-232 serial ports
To PC.
The present invention cone beam semi-circumference sampling CT three-dimensional reconstruction algorithm data to collecting carry out computational analysis, obtain CT image.
This algorithm is that inverse projection is rebuild, it is only necessary to carrying out the rotation slightly larger than 180 ° and take pictures, object stage only need to rotate slightly larger than 180 °.
Semi-circumference sampling algorithm can obtain enough reconstruction data in the range of 0~π+2 θ, and wherein θ is fan angle.Semi-circumference is sampled
Algorithm considerably reduces the data volume of scanning.Under same angular interval, half track scanning will greatly reduce scanning dose can't
To rebuild image impact, be can be actually used algorithm.
The method have technical effect that: the present invention provides a kind of low cost X ray CT imaging system, the use 16 of this system
Pixel-matrix X-ray detector, the low cost of cost, and large-area two-dimensional scanning can be realized, easy to use.The present invention
Utilize create distinctive signal acquiring system and cone beam semi-circumference sampling CT three-dimensional reconstruction algorithm carry out image repetition, calculated in
The CT image resolution ratio revealed is high.The present invention can promote x-ray imaging technology and the progress of system and reform, improves CT figure
The contrast of picture and resolution.
Present invention development to existing x-ray imaging technology undoubtedly has great revolutionary meaning.The present invention utilizes single/few picture
The two-dimensional scan of element X-ray detector realizes the high-resolution imaging of large area, for solving biomedical CT image cost height, differentiating
The problems such as rate is low, poor contrast provide a kind of feasible solution.The low cost of X ray CT imaging system, digitized, become
The emphasis that the present invention is paid close attention to.
The present invention uses adjacent pair of x-ray source to work simultaneously, on the one hand can reduce the operating power of each light source thus extend and penetrate
In the service life of spool, on the other hand can effectively reduce the motion artifacts of image.The present invention realizes low cost, it is not necessary to right
Existing CT equipment does the biggest structure and improves;Can apply in medical treatment CT or the bigger industry CT of radiation exposure dosage.
The present invention utilizes single/few pixel x-ray detector to carry out signals collecting, utilizes cone beam semi-circumference sampling CT three-dimensional afterwards
Algorithm for reconstructing generates CT image, and the CT image resolution ratio presented is high.
Accompanying drawing explanation
Fig. 1 is the structure composition schematic diagram of the embodiment of the present invention.
Fig. 2 is semi-circumference sampling algorithm explanation.
Detailed description of the invention
Seeing Fig. 1, the embodiment of the present invention is provided with PC end 1, high tension generator 2, X-ray bulb 3, servosystem, X-ray detection
Device 5;PC end 1 is connected with one end of high tension generator 2, and the other end of high tension generator 2 is connected with X-ray bulb 3, by X-ray ball
Pipe 3 sends X-ray;Servosystem is provided with three axle servo motion platforms and three axle servo controllers 44, and three axle servo motion platforms set
Lifting platform 41, translation stage 42 and object stage 43, one end of three axle servo controllers 44 is had to be connected with PC end 1, three axle servo controllers
Control the motion of three axle servo motion platforms;X-ray detector 5 is fixed on lifting platform 41, and lifting platform 41 is fixed on translation stage 42
On, lifting platform 41 is followed translation stage 42 and is moved together;Signal is acquired by X-ray detector 5, and signal is transmitted back to PC end 1,
Sample is placed on object stage 43, follows object stage rotary motion together;The data that detector is collected by PC end are bored
Pencil of forms semi-circumference sampling CT three-dimensional reconstruction algorithm calculates, the CT image of available sample, and the resolution of CT image is high, right
Better than degree.
Described X-ray detector can use single/few pixel x-ray detector, single/few pixel x-ray detector to use 16 pixels
Battle array, the most single-row 16 equally distributed forms of pixel are laid out, and the concept of single/few pixel is the most here.Single/few pixel x-ray is visited
Survey device is followed lifting platform and is moved together with translation stage, can carry out two-dimensional scan, collect abundant throwing in large-area scope
Shadow information and dot matrix signal, it is possible to achieve low cost, high-resolution CT imaging.
Described list/few pixel x-ray detector includes sensor and data acquiring control circuit two parts.
Described sensor can use 16 elemental silicon photodiodes that Bin Song group of Japan manufactures as sensor, by sensing difference
X-ray intensity converts optical signals to the signal of telecommunication, and model is S5668-121.Although simple silicon photoelectric diode wavelength response model
It is trapped among outside X-ray wavelength, but this 16 elemental silicon photodiode is combined with CsI (TI) scintillator, it becomes possible to use
In X-ray detection and CT imaging.
Described data acquiring control circuit can use STM32F407 that ST STMicw Electronics produces as microcontroller, with ADI
The AD conversion chip that Ya De promise produces is successively read S5668-121 as AD analog-digital converter, the FSMC interface utilizing MCU to carry
The 16 element detection point signals that silicon photoelectric diode sensor is changed out, and sent in real time to PC end by RS-232 serial line interface,
Use for follow-up CT three-dimensional reconstruction algorithm.
Described list/few pixel x-ray detector software algorithm part mainly includes that the FSMC that AD conversion chip initializes with MCU connects
Mouth initializes two parts.The parameters such as the sample frequency of AD conversion chip, over-sampling multiple, sampled signal input range are set by MCU
After reserving, it is possible to start AD conversion chip and sensor output signal is sampled and changes.The FSMC that it is carried by MCU
Interface sets the parameters such as address foundation, retention time, data setup time, clock division coefficient, FSMC access module respectively
After, it is possible to the data after using FSMC interface fast and stable to read AD conversion chip conversion, and send via RS-232 serial ports
To PC.
The present invention cone beam semi-circumference sampling CT three-dimensional reconstruction algorithm data to collecting carry out computational analysis, obtain CT image.
This algorithm is that inverse projection is rebuild, it is only necessary to carrying out the rotation slightly larger than 180 ° and take pictures, object stage only need to rotate slightly larger than 180 °.
Semi-circumference sampling algorithm can obtain enough reconstruction data in the range of 0~π+2 θ, and wherein θ is fan angle.Semi-circumference is sampled
Algorithm considerably reduces the data volume of scanning.Under same angular interval, half track scanning will greatly reduce scanning dose can't
To rebuild image impact, be can be actually used algorithm.
Fig. 2 is semi-circumference sampling algorithm explanation.X, y are the coordinates of rebuilt pixel, and β is the anglec of rotation of CT, and γ is through being weighed
Building the ray fan angle of pixel, θ is the angle sum of β and γ, and R is the X-ray point source distance to center of rotation, and L is X-ray
Point source is to the distance of rebuilt pixel, and U is L projection in the directionr, and a is the coordinate system vertical with R direction, and t is and L direction
Vertical coordinate system, ρ is the material absorption intensity to X-ray on this light, p be this light arrive on detector final
Intensity, γmaxIt is the maximum subtended angle at detector edge, FtBeing the weights of projection ray, ω (beta, gamma) is window function.
High voltage power supply is to provide DC high voltage and electric current to X-ray bulb and keep the stable device of voltage x current, typically by rising
The filtering of pressure transformer, filament transformer, high-voltage rectifying, voltage x current adjust and the parts such as stable, cooling and associated safety protection
Constitute.For X-ray tube, there are three physical quantitys needing to control, are tube voltage, tube current and irradiation time: X respectively
The tube current size of ray tube directly affects the amount in the X-ray unit time, and the tube voltage size of X-ray tube affects X-ray
Penetration power.Tube voltage, tube current and irradiation time together decide on the size of x-ray dose, therefore keep tube current and tube voltage
Stable to ensure the quality of exit Xray and dosage management and control it is critical that.
Described high voltage power supply uses the XRB series 150W high voltage power supply that Wei Siman high voltage power supply provides, and is provided that High voltage output, complete
Whole control signal and multiple miscellaneous function, exportable stable little ripple voltage and electric current.This type high voltage power supply has outside mutual
Lock function, it is possible to coordinate with radioprotector and temperature measurement component, is artificially opened and X-ray tube temperature mistake at preventer
Power supply is cut off time high.
X-ray bulb includes anode and two electrodes of negative electrode, is respectively used to accept the target of electron bombardment and launch the lamp of electronics
Silk.X-ray bulb is the device for producing X-ray.
Described X-ray bulb uses the KYW800 type small-power fixed anode generating positive and negative voltage X-ray ball that Shanghai section chin or cheek dimension electronics provides
Pipe: power 80W, anode voltage 80kV, anode current 1mA, focal spot size 1mm, beryllium window thickness 200 μm, X-radiation
20 ° of angle, filament voltage about 2.5V, heater current about 2A;Use the encapsulation of pyrite shell, improve heat dispersion and radiation shield
Covering performance, use air cooling way, interior filling insulating oil is used for High-Voltage Insulation and cooling.
Described servosystem is for adjusting single/few pixel x-ray detector and the locus of sample, by three axle servo motion platforms
With three axle servo controller compositions.
Described servosystem uses matches 7S series three axle servo motion platforms and the 7SC3 series three axle SERVO CONTROL that all photoelectricity provides
Device, 7S series three axle servo motion platforms include 7STA04A herd horses series motorized precision translation stage, 7SVA160 jack series lifting
Platform, 7SRA1 worm gear series motorized subject table.7S series three axle servo motion platforms are by RS-232 serial ports and 7SC3 series three
Axle servo controller connecting communication, can be automatically obtained adjustment of displacement: utilize the micro-stepping circuit design segmentation step angle of controller,
Improve displacement resolution;Multiple automatic operating scheme can be set, control one or more platform at different rates, displacement,
Amount of delay is repeatedly performed the action of setting automatically.
Described list/few pixel x-ray detector comprises hardware circuit and software algorithm two parts content.Described list/few pixel X is penetrated
Line detector hardware components includes sensor and data acquiring control circuit two parts.
Described list/few pixel x-ray detector sensor part uses the 16 elemental silicon photodiodes that Bin Song group of Japan manufactures
As sensor, converting optical signals to the signal of telecommunication by sensing different x-ray intensity, model is S5668-121.Although it is single
Pure silicon photoelectric diode wavelength response range is outside X-ray wavelength, but by this 16 elemental silicon photodiode and CsI (TI)
Scintillator combines, it becomes possible to apply in X-ray detection and CT imaging.
Used by single/few pixel x-ray detector, the wavelength response range of silicon photoelectric diode is 340-1100nm, peak value sensitivity ripple
A length of 960nm, peak wavelength luminous sensitivity is 0.54-0.66A/W.The X-ray sensitivity of CsI (TI) scintillator used is
6.8nA.Each element has the useful detection area of 1.175mm*2.0mm, and adjacent spacing is 1.575mm, overall 16 elements
Linear arrangement, in the PCB of 25.4mm length, is equivalent to possessed 16 sensing points altogether.
Described list/few pixel x-ray detector data acquisition control circuit part uses the STM32F407 that ST STMicw Electronics produces
As microcontroller, the AD conversion chip produced using the promise of ADI Ya De, as AD analog-digital converter, utilizes MCU to carry
FSMC interface is successively read the 16 element detection point signals that S5668-121 silicon photoelectric diode sensor is changed out, and passes through
RS-232 serial line interface sends in real time to PC end, uses for follow-up CT algorithm for reconstructing.
The 16 element detection point signals that S5668-121 silicon photoelectric diode sensor is changed out keep through signal condition, sampling
(S/H), the multiplexing process such as (MUX) signal output is connected to the input interface of AD conversion chip analog-digital converter, AD turns
Change chip and the analogue signal on input interface is converted to digital signal, send MCU parallel to for subsequent treatment simultaneously.MCU
Sensor signal after utilizing FSMC (variable static storage controller) the interface fast and stable carried to read AD conversion chip conversion,
Data-transmission efficiency is high, real-time.The sensor signal read is sent in real time to PC by MCU by RS-232 serial line interface
Machine.
AD conversion chip be built-in with simulation input clamping protection, follow the tracks of hold amplifier, second order frequency overlapped-resistable filter, 16 gradually
Approach type ADC, digital filter, 2.5V reference voltage source, reference voltage buffering and high-speed parallel and serial line interface.Use
Single supply 5V powers, can process ± 5V and ± the true bipolar input signal of 10V, 6 passages all can be with 200kSPS's simultaneously
Throughput rate is sampled.Input clamp protection circuits can withstand up to ± the voltage of 16.5V.AD conversion chip have in sheet filtering and
High input impedance, it is not necessary to drive operational amplifier and external bipolar power supply the characteristic such as to power.The 3dB cut-off of frequency overlapped-resistable filter
Frequency is 22kHz;When sampling rate is 200kSPS, it has the anti-aliasing rejection characteristic of 40dB.AD conversion chip encapsulates
Use 64 foot LQFP forms, have that volume is little, lightweight, be operable with-40~adverse circumstances that+80 DEG C interior, anti-interference
The feature such as strong.
FSMC (Flexible Static Memory Controller, variable static storage controller) is distinctive in MCU series
Storage control mechanism.Why it is referred to as " variable ", is owing to by the setting to special function register, FSMC can basis
Different external memory storage types, sends the corresponding data/address/control signal type speed with matched signal, so that
STM32 Series of MCU can not only apply various dissimilar, the external static memorizer of friction speed, and can be
Extend the static memory of number of different types in the case of not increasing external devices simultaneously, meet system design to memory capacity,
Small product size and the composite request of cost.
After the parameters such as the sample frequency of AD conversion chip, over-sampling multiple, sampled signal input range are set by MCU, so that it may
Sensor output signal sampled and changes starting AD conversion chip.We are by after AD conversion chip internal mode number conversion
The data register of temporal data regards a kind of memorizer as, is connected with AD conversion chip output interface by the FSMC interface of MCU,
After setting the parameters such as address foundation, retention time, data setup time, clock division coefficient, FSMC access module respectively,
Data after FSMC interface fast and stable just can be used to read conversion, and send to PC via RS-232 serial ports.
By above-mentioned high voltage power supply, X-ray bulb, servosystem (three axle servo motion platforms, three axle servo controllers), list
The two-dimensional scan of the system of/few pixel x-ray detector we can be obtained by single/few pixel x-ray detector realizes big face
The method of long-pending high-resolution ct image imaging, described in detail below:
High voltage power supply is connected with X-ray bulb, make X-ray bulb produce X-ray, x-ray bombardment on testing sample, warp
On single/few pixel detector sensor, the light intensity of varying strength is formed after sample attenuation by absorption.Single/few pixel detector passes through
RS-232 Serial Port Line is connected with the RS-232 serial ports of PC, and certain the moment light intensity obtained is converted to digital signal after treatment
And send to PC via RS-232 serial ports.Perform semi-circumference sampling reconstruction algorithm on PC again and obtain CT image.
Owing to single/few pixel detector only possesses 16 sensing points, in order to obtain 256*256 or 512*512 that commonly use or even more
The CT image of many pixels, it would be desirable to utilize servosystem (three axle servo motion platforms, three axle servo controllers) to single/
Few pixel detector is controlled with testing sample placement location, to form complete image.
Three axle servo motion platforms and three axle servo controllers are connected, and tri-axial motion controller passes through RS-232 Serial Port Line and PC
It is connected, the control to three axle servo motion platforms can be realized by supporting upper computer software, including rotating, translate, lifting.
Single/few pixel detector is positioned on 7SVA160 jack series lifting platform by we, and 7SVA160 jack series lifting platform is put
It is placed in 7STA04A and herds horses on series motorized precision translation stage, thus can realize single/few pixel detector translation by controller and rise
The action of fall, finally gives 256*256 image complete under a certain detection angle.It addition, wanting according to CT image image-forming principle
Asking, sample to be tested is positioned in 7SRA1 worm gear series motorized subject table by we, is controlled the rotation of sample to be tested by controller,
So can be obtained by the image under different detection angle.Repeat this step, may finally obtain under multiple detection angle
256*256 image, then obtain CT image via the semi-circumference sampling reconstruction algorithm on PC.
Described semi-circumference sampling reconstruction algorithm particular content is as follows:
In the algorithm for reconstructing of collimated light beam, it has been found that its limit of integration is between 0~π.And for fladellum, 0~π
Scope be not enough to rebuild faultage image accurately.Therefore the limit of integration of Fan-beam Reconstruction is between 0~2 π.In fact, 0~2 π
In limit of integration, hence it is evident that have the beam of overlap.If it is considered that with minimum non-overlapped beam reconstruction faultage image, Ke Yiyong
Scope less than 0~2 π is rebuild.Here it is the Producing reason of semi-circumference sampling algorithm.
Semi-circumference sampling algorithm can obtain enough reconstruction data in the range of 0~π+2 θ, and wherein θ is fan angle.Semicircle
All sampling algorithms considerably reduce the data volume of scanning.Under same angular interval, half track scanning will greatly reduce scanning dose
Can't to rebuild image impact, be can be actually used algorithm.And semi-circumference sampling algorithm is also spiral algorithm base
Plinth.Therefore half track FDK algorithm is the content must studied in general-purpose algorithm.The most first introduce fladellum semi-circumference sampling algorithm.
By two class parameters, the algorithm of collimated light beam and fladellum can represent that (θ, t) with (beta, gamma), as shown in Figure 2 respectively.
Can obtain following relation:
θ=β+γ, t=R sin γ
Or it is equivalent to
β=θ-γ, γ=arcsin (t/R)
In planar detector, if fan-shaped light source, then there is γ=arctan (a/R).
By the formula of wave filtering template
Parallel beam just can complete complete data reconstruction in interval θ ∈ [0, π].And can Fan-beam Reconstruction is interval from us
Become β ∈ [-γmax,π+γmax], so, relative to the Star Simulator algorithm of the β ∈ [0,2 π] of primal algorithm, semicircle can be referred to as
All sampling algorithms.Semi-circumference sampling algorithm can be with arbitrarily angled as original position, as long as its stroke meets π+2 γmaxThis
Part;Semi-circumference sampling algorithm can produce redundant data in the initial of collection data and final position, and its scope of data is in fan angle
±γmaxIn.
Understanding for two dimension algorithm contributes to understand cone-beam light algorithm.Generally semi-circumference sampling reconstruction light sliding window is filtered.
Semi-circumference sampled data can do primary screening before inverse projection, and the data for projection so measuring twice is multiplied by corresponding weights also
Classification is unitized.Simplest window function is exactly two-valued function, and redundant data is filtered.But so can produce substantial amounts of artifact.
It is described below window function to eliminate artifact
Two-dimensional scan through above-mentioned utilization list/few pixel x-ray detector realizes large area high-resolution ct image image-forming principle
And algorithm explanation is discussed in detail, it is possible to understand that specific embodiment of the present invention.
Described few pixel x-ray detector software algorithm part mainly includes that MCU interface initialization initializes two with AD conversion chip
Part.
FSMC (Flexible Static Memory Controller, variable static storage controller) is distinctive in MCU series
Storage control mechanism.Why it is referred to as " variable ", is owing to by the setting to special function register, FSMC can basis
Different external memory storage types, sends the corresponding data/address/control signal type speed with matched signal, so that
MCU Series of MCU can not only apply various dissimilar, the external static memorizer of friction speed.
The parameters such as the sample frequency of AD conversion chip, over-sampling multiple, sampled signal input range are set by microcontroller
After, it is possible to start AD conversion chip and sensor output signal is sampled and changes.We are by AD conversion chip internal mode
After number conversion, the data register of temporal data regards a kind of memorizer as, is exported with AD conversion chip by the FSMC interface of MCU
Interface is connected, and sets address foundation, retention time, data setup time, clock division coefficient, FSMC access module respectively
After parameter, it is possible to the data after using FSMC interface fast and stable to read conversion, and send to PC via RS-232 serial ports
Machine.
The sampling of this cone beam semi-circumference and corresponding algorithm for reconstructing can obtain enough reconstruction data in the range of 0~π+2 θ,
Wherein θ is fan angle.This algorithm substantially shortens the sampling time, decreases the data volume of scanning.Under same angular interval, half rail
Road scanning will greatly reduce scanning dose can't to reconstruction image impact, be can be actually used algorithm.
The present invention utilizes single/few pixel x-ray detector to carry out large-area scanning on two dimensional surface, utilizes original creation spy afterwards
Some signal acquiring systems send data on PC, and recycling cone beam semi-circumference sampling CT three-dimensional reconstruction algorithm carries out figure
Image reconstruction.A kind of low cost X ray CT imaging system low cost that the present invention provides, the CT image resolution ratio presented is high.
Claims (7)
1.X ray CT imaging system, it is characterised in that be provided with PC end, high tension generator, X-ray bulb, servosystem, X penetrate
Line detector;PC end is connected with one end of high tension generator, and the other end of high tension generator is connected with X-ray bulb, by X-ray
Bulb sends X-ray;Servosystem is provided with three axle servo motion platforms and three axle servo controllers, and three axle servo motion platforms are provided with
Lifting platform, translation stage and object stage, one end of three axle servo controllers is connected with PC end, and three axle servo controllers control three axles and watch
Take the motion of motion platform;X-ray detector is fixed on lifting platform, and lifting platform is fixed on translation stage, and translation followed by lifting platform
Platform moves together;Signal is acquired by X-ray detector, and signal is transmitted back to PC end, and sample is placed on object stage,
Follow object stage rotary motion together;The data that detector is collected by PC end carry out cone beam semi-circumference sampling CT three-dimensional reconstruction and calculate
Method calculates, and obtains the CT image of sample.
2. X ray CT imaging system as claimed in claim 1, it is characterised in that described X-ray detector uses single/few pixel X to penetrate
Line detector.
3. X ray CT imaging system as claimed in claim 2, it is characterised in that described list/few pixel x-ray detector uses 16
Pixel-matrix.
4. X ray CT imaging system as claimed in claim 2, it is characterised in that described list/few pixel x-ray detector includes
Sensor and data acquiring control circuit.
5. X ray CT imaging system as claimed in claim 4, it is characterised in that described sensor uses Bin Song group of Japan system
The 16 elemental silicon photodiodes made are as sensor.
6. X ray CT imaging system as claimed in claim 4, it is characterised in that described data acquiring control circuit uses ST meaning
The STM32F407 of method semiconductor production is as microcontroller, and the AD conversion chip produced using the promise of ADI Ya De is as AD mould
Number converter, the FSMC interface utilizing MCU to carry is successively read 16 that S5668-121 silicon photoelectric diode sensor is changed out
Element detection point signal, and sent in real time to PC end by RS-232 serial line interface, use for follow-up CT three-dimensional reconstruction algorithm.
7. X ray CT imaging system as claimed in claim 2, it is characterised in that described list/few pixel x-ray detector software
Algorithm part mainly includes that AD conversion chip initializes the FSMC interface initialization two parts with MCU.MCU is to AD conversion chip
Sample frequency, over-sampling multiple, sampled signal input range parameter set after, start AD conversion chip to sensor output letter
Number sample and change;When MCU sets address foundation respectively to its FSMC interface carried, retention time, data are set up
Between, after clock division coefficient, FSMC access module parameter, use FSMC interface fast and stable read AD conversion chip conversion after
Data, and via RS-232 serial ports send to PC.
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106959640A (en) * | 2017-04-16 | 2017-07-18 | 深圳市安尔通科技有限公司 | A kind of channel-type rays safety detection apparatus |
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CN107192598A (en) * | 2017-04-10 | 2017-09-22 | 中国科学技术大学 | A kind of grenz ray freezes the preparation method of Imaged samples |
WO2019000601A1 (en) * | 2017-06-27 | 2019-01-03 | 西安立人医学科技有限公司 | Cone beam ct multi-directional scanning apparatus |
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Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1705455A (en) * | 2002-10-21 | 2005-12-07 | 皇家飞利浦电子股份有限公司 | Conebeam computed tomography imaging |
CN1994230A (en) * | 2005-12-31 | 2007-07-11 | 清华大学 | X-CT scanning system |
CN101071111A (en) * | 2006-05-08 | 2007-11-14 | 清华大学 | Multi-vision aviation container safety inspection system and method |
CN101416880A (en) * | 2008-11-20 | 2009-04-29 | 王乔生 | Movable C-arm three-dimensional filming system and imaging method thereof |
CN101455574A (en) * | 2009-01-08 | 2009-06-17 | 华中科技大学 | Imaging system and method |
CN102106740A (en) * | 2011-03-11 | 2011-06-29 | 河海大学 | X-ray compound tomoscanning imaging system and method |
CN103363924A (en) * | 2013-07-15 | 2013-10-23 | 中国科学院空间科学与应用研究中心 | Compressing three-dimension calculation ghost imaging system and method |
CN104597062A (en) * | 2015-02-02 | 2015-05-06 | 天津三英精密仪器有限公司 | Cylindrical beam large visual field X-ray computed tomography (CT) imaging system |
CN104764757A (en) * | 2015-04-03 | 2015-07-08 | 燕山大学 | Real-time X-ray imaging system with micro scanning |
CN104849769A (en) * | 2015-05-26 | 2015-08-19 | 浙江传媒学院 | System and method of three-dimension range imaging |
-
2016
- 2016-05-25 CN CN201610352174.3A patent/CN105943071A/en active Pending
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1705455A (en) * | 2002-10-21 | 2005-12-07 | 皇家飞利浦电子股份有限公司 | Conebeam computed tomography imaging |
CN1994230A (en) * | 2005-12-31 | 2007-07-11 | 清华大学 | X-CT scanning system |
CN101071111A (en) * | 2006-05-08 | 2007-11-14 | 清华大学 | Multi-vision aviation container safety inspection system and method |
CN101416880A (en) * | 2008-11-20 | 2009-04-29 | 王乔生 | Movable C-arm three-dimensional filming system and imaging method thereof |
CN101455574A (en) * | 2009-01-08 | 2009-06-17 | 华中科技大学 | Imaging system and method |
CN102106740A (en) * | 2011-03-11 | 2011-06-29 | 河海大学 | X-ray compound tomoscanning imaging system and method |
CN103363924A (en) * | 2013-07-15 | 2013-10-23 | 中国科学院空间科学与应用研究中心 | Compressing three-dimension calculation ghost imaging system and method |
CN104597062A (en) * | 2015-02-02 | 2015-05-06 | 天津三英精密仪器有限公司 | Cylindrical beam large visual field X-ray computed tomography (CT) imaging system |
CN104764757A (en) * | 2015-04-03 | 2015-07-08 | 燕山大学 | Real-time X-ray imaging system with micro scanning |
CN104849769A (en) * | 2015-05-26 | 2015-08-19 | 浙江传媒学院 | System and method of three-dimension range imaging |
Non-Patent Citations (2)
Title |
---|
朱翚: "利用MATLAB进行图像重建的算法研究", 中国优秀博硕士学位论文全文数据库(硕士) 信息科技辑, no. 12, pages 7 - 14 * |
郭荣: "扇形束CT局部重建算法研究", 中国优秀硕士学位论文全文数据库 信息科技辑, no. 7, pages 14 - 22 * |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107192598A (en) * | 2017-04-10 | 2017-09-22 | 中国科学技术大学 | A kind of grenz ray freezes the preparation method of Imaged samples |
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CN106959640A (en) * | 2017-04-16 | 2017-07-18 | 深圳市安尔通科技有限公司 | A kind of channel-type rays safety detection apparatus |
CN107102014A (en) * | 2017-06-06 | 2017-08-29 | 北京邮电大学 | Industry CT imaging control system and control method |
CN107102014B (en) * | 2017-06-06 | 2019-09-24 | 北京邮电大学 | Industry CT imaging control system and control method |
WO2019000601A1 (en) * | 2017-06-27 | 2019-01-03 | 西安立人医学科技有限公司 | Cone beam ct multi-directional scanning apparatus |
CN109350109A (en) * | 2018-12-06 | 2019-02-19 | 余姚德诚科技咨询有限公司 | Multi-functional dentistry scanning system |
CN109350109B (en) * | 2018-12-06 | 2022-03-04 | 北京锐视康科技发展有限公司 | Multifunctional dental scanning system |
WO2022109859A1 (en) * | 2020-11-25 | 2022-06-02 | 江苏康众数字医疗科技股份有限公司 | Tube having motion compensation function and radiographic imaging system having same |
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