CN105935297A - X-ray grating phase-contrast imaging CT system - Google Patents
X-ray grating phase-contrast imaging CT system Download PDFInfo
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- CN105935297A CN105935297A CN201610460755.9A CN201610460755A CN105935297A CN 105935297 A CN105935297 A CN 105935297A CN 201610460755 A CN201610460755 A CN 201610460755A CN 105935297 A CN105935297 A CN 105935297A
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- module
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- optical grating
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- contrast imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computerised tomographs
- A61B6/032—Transmission computed tomography [CT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/04—Positioning of patients; Tiltable beds or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/44—Constructional features of apparatus for radiation diagnosis
- A61B6/4429—Constructional features of apparatus for radiation diagnosis related to the mounting of source units and detector units
- A61B6/4452—Constructional features of apparatus for radiation diagnosis related to the mounting of source units and detector units the source unit and the detector unit being able to move relative to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/484—Diagnostic techniques involving phase contrast X-ray imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/02—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material
- G01N23/04—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material
Abstract
The invention provides an X-ray grating phase-contrast imaging CT system. The X-ray grating phase-contrast imaging CT system comprises an X-ray light source, a source grating, a beam splitting grating, an analysis grating and a detector which are arranged in sequence, wherein the X-ray light source and the source grating are relatively and fixedly integrated to form a first module, the analysis grating and the detector are relatively and fixedly integrated to form a second module, the first module, the beam splitting grating and the second module rotate around a sample table between the beam splitting grating and the analysis grating, and a stereoscopic image is obtained through scanning. In the X-ray grating phase-contrast imaging CT system, the X-ray light source and the source grating are relatively and fixedly integrated to form the first module, the analysis grating and the detector are relatively and fixedly integrated to form the second module, so that independent parts are decreased, the system can be concise and simple in operation and high in stability. The interference to the sample table can be also reduced by fixing the sample table and turning other parts, and improvement of the clinic applicability of the X-ray grating phase-contrast imaging CT system is promoted.
Description
Technical field
The present invention relates to technical field of medical instruments, particularly relate to a kind of X-ray optical grating contrast imaging CT system
System.
Background technology
1895, Germany scientist roentgen found X-ray, 1896, and this discovery is applied to medical science and shows
Shadow.Through the development of more than 100 years, X-ray technology was the most highly developed, became a kind of inspection that hospital is conventional
Look into and treatment means.
X-ray is applied to medical diagnosis, the penetration of Main Basis X-ray, differential absorption, photosensitive work
With and fluorescence.During due to X-ray through human body, receive absorption in various degree, such as bone absorption
Amount of x-ray is more than the amount that muscle absorbs, then the most different, the most just by the amount of x-ray after human body
Carry the information of partes corporis humani point Density Distribution, the fluorescence caused on fluorescent screen or on photographic film
Or the power of photosensitization just has bigger difference, thus on fluorescent screen or on film, would indicate that different densities
Shade.According to the contrast of shadow intensity, in conjunction with clinical diagnosis, i.e. can determine whether that this position of human body is the most normal.
X-ray absorption imaging, for sclerous tissueses such as skeletons, can obtain good image；But for blood vessel, fat
The soft tissues such as fat, muscle, mammary gland, x-ray imaging technology obtain image be blur, differentiate unclear
's.
X-ray phase contrast is a kind of new technique developed in recent years, by detection X-ray through material
Phase place change (i.e. phase shift) carrys out imaging.In theory, for the soft tissue of human body, X-ray phase place
Contrast imaging technology can provide and become the image contrast of image height thousand times than conventional suction and measure sensitivity.
At present, X-ray phase contrast technology is also in experimental stage, and some critical technical problems also cannot
Solve.As crystal interferometric method is harsh to light source requirements, using synchrotron radiation light source, visual field is little, at present
The experiment of mouselet can only be done；Free propagation method and diffraction enhanced imaging method harshness same to light source requirements, use same
Step radiating light source or Microfocus X-ray light source.They are big due to volume, involve great expense, medical science unclear prospect.
At present, the most clinical is X-ray optical grating contrast imaging CT system, such as Fig. 1,
This X-ray optical grating contrast imaging CT system uses common X-ray source, 3 blocks of gratings and detector, its
In 3 blocks of gratings be source grating, beam-splitting optical grating, analysis grating respectively.This X-ray optical grating contrast imaging CT
System all parts is separate, runs complexity, lacks automation mechanized operation, and precision is difficult to ensure that；Generally need
Want specimen rotating holder just can obtain CT image, the most not there is practical significance.
Summary of the invention
In view of this, in order to overcome defect and the problem of prior art, the present invention provides a kind of X-ray grating
Phase contrast imaging CT system.
A kind of X-ray optical grating contrast imaging CT system, including the X-ray source that order is arranged successively, source
Grating, beam-splitting optical grating, analysis grating and detector, described X-ray source and described source grating are relatively fixed
Be integrated into the first module, described analysis grating and described detector are integrated into the second module with being relatively fixed,
Described first module, described beam-splitting optical grating and described second module are around being fixed on described beam-splitting optical grating and described
Analyzing the sample stage between grating to rotate, scanning obtains stereoscopic image.
In the present invention one better embodiment, also include that control system, described control system include translating control
Unit, described translation control unit connects described first module, described beam-splitting optical grating, described sample stage and institute
State the second module, control described first module, described beam-splitting optical grating, described sample stage and described second module
Translate along light path respectively.
In the present invention one better embodiment, described translation control unit is controlled by four piezoelectric ceramic motors
Described first module, described beam-splitting optical grating, described sample stage and described second module translate along light path respectively.
In the present invention one better embodiment, equipped with in real time to computer feedback bit on described piezoelectric ceramic motor
The encoder of confidence breath, described computer is assigned movement instruction by a control module and is controlled described piezoelectricity pottery
Porcelain motor drives described first module, described beam-splitting optical grating, described sample stage and described second module edge respectively
Light path translates.
In the present invention one better embodiment, described first module and described beam-splitting optical grating are integrated into further
One rotary body, it is the second rotary body that described second module independently forms, and described control unit also includes connecting institute
Stating the first rotary body and the rotation control unit of described second rotary body, described rotation control unit controls described
First rotary body and described second rotary body are with described sample stage as the center of circle, and rotate around described sample stage.
In the present invention one better embodiment, described rotation control unit is connected by gear and piezoelectric ceramic motor
Connect described first rotary body and described second rotary body.
In the present invention one better embodiment, the sweep time of described sample stage, scanning times and revolve every time
Gyration is controlled by described computer.
In the present invention one better embodiment, also include being connected between described control module and described detector
Image transmission module.
Relative to prior art, in described X-ray optical grating contrast imaging CT system, described X-ray source
The first module, described analysis grating it is integrated into being relatively fixed relative with described detector solid with described source grating
Surely it is integrated into the second module, thereby reduces individual components, can make that system is succinct, stability is high, operation
Simply.It addition, fixed by sample stage, and rotate other parts, the interference to sample stage can be reduced again, have
It is beneficial to improve the clinical practice of described X-ray optical grating contrast imaging CT system.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of X-ray optical grating contrast imaging CT system of the prior art；
The schematic diagram of the X-ray optical grating contrast imaging CT system that Fig. 2 provides for a preferred embodiment of the present invention.
Detailed description of the invention
For the ease of understanding the present invention, below with reference to relevant drawings, the present invention is described more fully.
Accompanying drawing gives the better embodiment of the present invention.These are only the preferred embodiments of the present invention, and unprovoked
This limits the scope of the claims of the present invention, every equivalent structure utilizing description of the invention and accompanying drawing content to be made
Or equivalence flow process conversion, or directly or indirectly it is used in other relevant technical fields, the most in like manner it is included in this
In the scope of patent protection of invention.
Unless otherwise defined, all of technology used herein and scientific terminology and the technology belonging to the present invention
The implication that the technical staff in field is generally understood that is identical.The art used the most in the description of the invention
Language is intended merely to describe the purpose of specific embodiment, it is not intended that in limiting the present invention.Used herein
Term " and/or " include the arbitrary and all of combination of one or more relevant Listed Items.
Referring to Fig. 2, a preferred embodiment of the present invention provides a kind of X-ray optical grating contrast imaging CT system
100, including the X-ray source 10 that order is arranged successively, source grating 20, beam-splitting optical grating 30, analyze grating
40 and detector 50, described X-ray source 10 and described source grating 20 be integrated into the first mould with being relatively fixed
Block 120, described analysis grating 40 and described detector 50 are integrated into the second module 450, institute with being relatively fixed
State the first module 120, described beam-splitting optical grating 30 and described second module 450 around being fixed on described beam splitting light
Sample stage 60 between grid 30 and described analysis grating 40 rotates, and scanning obtains stereoscopic image.
In the present embodiment, described X-ray optical grating contrast imaging CT system 100 also includes control system, institute
Stating control system to include translating control unit, described translation control unit connects described first module 120, described
Beam-splitting optical grating 30, described sample stage 60 and described second module 450, described translation control unit controls described
First module 120, described beam-splitting optical grating 30, described sample stage 60 and described second module 450 are respectively along light
Road translates.Specifically, described translation control unit includes connecting described first module 120, described beam splitting respectively
Grating 30, described sample stage 60 and four piezoelectric ceramic motors 70 of described second module 450 are described flat
Move control unit and control described first module 120, described beam splitting light by described four piezoelectric ceramic motors 70
Grid 30, described sample stage 60 and described second module 450 translate along light path respectively.Thus, it is possible to regulation institute
State the first module 120, described beam-splitting optical grating 30, described sample stage 60 and described second module 450 two-by-two it
Between relative distance, be conducive to described sample stage 60 is scanned obtaining imaging clearly.
It is understood that described sample stage 60 is for carrying human body to be measured.
Preferably, equipped with in real time to the volume of computer 80 feedback position information on described piezoelectric ceramic motor 70
Code device (not shown), described computer 80 is assigned movement instruction by a control module 90 and is controlled described pressure
Electroceramics motor 70 drives described first module 120, described beam-splitting optical grating 30, described sample stage 60 and institute
State the second module 450 to translate along light path respectively.In the present embodiment, described X-ray optical grating contrast imaging CT
System 100 also includes the image transmission module being connected between described control module 90 and described detector 50
95, the image transmitting that described detector 50 is obtained by described image transmission module 95 to described control module 90,
And finally transmission to described computer 80 stores or processes.
It is understood that described computer 80 is connected with described control module 90, described computer 80
For industrial computer.
Further, described first module 120 and described beam-splitting optical grating 30 are integrated into the first rotary body 123,
It is the second rotary body 451 that described second module 450 independently forms, and described control unit also includes connecting described
One rotary body 123 and the rotation control unit of described second rotary body 451, described rotation control unit controls
Described first rotary body 123 and described second rotary body 451 are with described sample stage 60 as the center of circle, and around institute
State sample stage 60 to rotate.Thus, it is possible to described sample stage 60 is carried out 360 ° of rotation sweeps, it is thus achieved that three-dimensional
Image.
In the present embodiment, described rotation control unit passes through gear (not shown) and a piezoelectric ceramic motor
70 connect described first rotary body 123 and described second rotary body 451.
It is understood that the sweep time of described sample stage 60, scanning times and every time the anglec of rotation by
Described computer 80 controls.
Relative to prior art, in described X-ray optical grating contrast imaging CT system 100, described X-ray
Light source 10 and described source grating 20 are integrated into the first module 120, described analysis grating 40 and with being relatively fixed
Described detector 50 is integrated into the second module 450 with being relatively fixed, and thereby reduces individual components, can make be
System is succinct, stability is high, simple to operate.It addition, fixed by sample stage 60, and rotate other parts, again
The interference to sample stage 60 can be reduced, be conducive to improving described X-ray optical grating contrast imaging CT system 100
Clinical practice.
Embodiment described above only have expressed the several embodiments of the present invention, and it describes more concrete and detailed,
But therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that, for this area
Those of ordinary skill for, without departing from the inventive concept of the premise, it is also possible to make some deformation and
Improving, these broadly fall into protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be with appended
Claim is as the criterion.
Claims (8)
1. an X-ray optical grating contrast imaging CT system, including successively order arrange X-ray source,
Source grating, beam-splitting optical grating, analysis grating and detector, it is characterised in that described X-ray source and described
Source grating is integrated into the first module with being relatively fixed, and described analysis grating and described detector collect with being relatively fixed
Becoming the second module, described first module, described beam-splitting optical grating and described second module are described around being fixed on
Sample stage between beam-splitting optical grating and described analysis grating rotates, and scanning obtains stereoscopic image.
2. X-ray optical grating contrast imaging CT system as claimed in claim 1, it is characterised in that also wrap
Including control system, described control system includes translating control unit, and described translation control unit connects described the
One module, described beam-splitting optical grating, described sample stage and described second module, control described first module, institute
State beam-splitting optical grating, described sample stage and described second module to translate along light path respectively.
3. X-ray optical grating contrast imaging CT system as claimed in claim 2, it is characterised in that described
Translation control unit controls described first modules, described beam-splitting optical grating, described by four piezoelectric ceramic motors
Sample stage and described second module translate along light path respectively.
4. X-ray optical grating contrast imaging CT system as claimed in claim 3, it is characterised in that described
Equipped with in real time to the encoder of computer feedback position information on piezoelectric ceramic motor, described computer passes through one
Individual control module is assigned movement instruction and is controlled described piezoelectric ceramic motor driving described first module, described beam splitting
Grating, described sample stage and described second module translate along light path respectively.
5. X-ray optical grating contrast imaging CT system as claimed in claim 4, it is characterised in that described
First module and described beam-splitting optical grating are integrated into the first rotary body further, described second module independently form into
Second rotary body, described control unit also includes connecting described first rotary body and the rotation of described second rotary body
Turning control unit, described rotation control unit controls described first rotary body and described second rotary body with described
Sample stage is the center of circle, and rotates around described sample stage.
6. X-ray optical grating contrast imaging CT system as claimed in claim 5, it is characterised in that described
Rotation control unit connects described first rotary body and described second by gear and piezoelectric ceramic motor and rotates
Body.
7. X-ray optical grating contrast imaging CT system as claimed in claim 5, it is characterised in that described
The sweep time of sample stage, scanning times and each anglec of rotation are controlled by described computer.
8. X-ray optical grating contrast imaging CT system as claimed in claim 4, it is characterised in that also wrap
Include the image transmission module being connected between described control module and described detector.
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| CN107085000A (en) * | 2017-04-17 | 2017-08-22 | 深圳先进技术研究院 | X-ray grating phase contrast imaging automated calibration system and method |
| CN107714067A (en) * | 2017-10-23 | 2018-02-23 | 中国科学院苏州生物医学工程技术研究所 | Mammary gland phase contrast CT imaging devices |
| CN107748341A (en) * | 2017-10-23 | 2018-03-02 | 中国科学院苏州生物医学工程技术研究所 | High contrast low dosage phase contrast CT image-forming device |
| CN109425624A (en) * | 2017-09-05 | 2019-03-05 | 株式会社岛津制作所 | X-ray imaging device |
| CN109470729A (en) * | 2017-09-06 | 2019-03-15 | 株式会社岛津制作所 | Radioactive ray phase difference camera |
| US11150361B2 (en) | 2018-11-19 | 2021-10-19 | Prismatic Sensors Ab | X-ray imaging system for phase contrast imaging using photon-counting events |
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