CN107714067A - Mammary gland phase contrast CT imaging devices - Google Patents

Mammary gland phase contrast CT imaging devices Download PDF

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Publication number
CN107714067A
CN107714067A CN201710992907.4A CN201710992907A CN107714067A CN 107714067 A CN107714067 A CN 107714067A CN 201710992907 A CN201710992907 A CN 201710992907A CN 107714067 A CN107714067 A CN 107714067A
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Prior art keywords
mammary gland
phase contrast
imaging devices
grating
splitting optical
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Pending
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CN201710992907.4A
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Chinese (zh)
Inventor
雷恒波
曾维俊
孙海旋
王钟周
王骏
孙明山
杨晓冬
高昆
刘刚
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University of Science and Technology of China USTC
Suzhou Institute of Biomedical Engineering and Technology of CAS
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University of Science and Technology of China USTC
Suzhou Institute of Biomedical Engineering and Technology of CAS
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Application filed by University of Science and Technology of China USTC, Suzhou Institute of Biomedical Engineering and Technology of CAS filed Critical University of Science and Technology of China USTC
Priority to CN201710992907.4A priority Critical patent/CN107714067A/en
Publication of CN107714067A publication Critical patent/CN107714067A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/502Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of breast, i.e. mammography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/40Arrangements for generating radiation specially adapted for radiation diagnosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/42Arrangements for detecting radiation specially adapted for radiation diagnosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Apparatus For Radiation Diagnosis (AREA)

Abstract

The invention discloses a kind of mammary gland phase contrast CT imaging devices, including:Pedestal, the turntable being arranged above the pedestal, the rotation steelframe being arranged on the turntable and it is erected at scanning bed above the rotation steelframe, X-ray source, source grating, beam-splitting optical grating, analysis grating and detector is disposed with along optical path direction on the rotation steelframe;Described beam-splitting optical grating lower end is provided with micro-displacement stepping mechanism, and described micro-displacement stepping mechanism includes flexure hinge mechanism and drive mechanism.The mammary gland phase contrast CT imaging devices of the present invention, can obtain clearly mammary gland CT images, and can substantially reduce the dose of radiation that patient is received, and reduce equipment and are negatively affected to caused by patient body.Stability Analysis of Structures of the present invention is reliable, easy to operate, is well positioned to meet user's request, has wide market prospects.

Description

Mammary gland phase contrast CT imaging devices
Technical field
The present invention relates to X-ray technical field of imaging, more particularly to a kind of mammary gland phase contrast CT imaging devices.
Background technology
Mammary gland disease is the common disease of women, and the particularly incidence of disease of the breast cancer in female malignant accounts for first Position, there is greatly threat to the health of women.Mammary X-ray photography is to detect the most basic image method of breast cancer, is applied to Breast cancer examination can reduce its death rate.But X-ray photographic has certain limitation, Traditional x-ray imaging technique is to be based on thing The difference of confrontation X-ray absorption property, the material formed for heavy element materials such as metals, Traditional x-ray imaging technique can Good image contrast is obtained, but for the material of the light element such as carbon, oxygen, nitrogen, oxygen material composition, such as the breast in medical imaging The human body soft tissues such as gland, blood vessel, fat, cartilage, their absorptions to X ray are very faint, these be organized in Traditional x-ray into As the image obtained under technology be blur, differentiate it is unclear.
The content of the invention
In view of the above-mentioned deficiencies in the prior art, the technical problem to be solved by the present invention is that provide a kind of mammary gland phase contrast CT imaging devices.
In order to solve the above technical problems, the technical solution adopted by the present invention is:A kind of mammary gland phase contrast CT imaging devices, bag Include:Pedestal, the turntable being arranged above the pedestal, the rotation steelframe being arranged on the turntable and it is erected at the rotation Turn scanning bed above steelframe, X-ray source, source grating, beam splitting light are disposed with along optical path direction on the rotation steelframe Grid, analysis grating and detector;
Described source grating, beam-splitting optical grating and analysis grating is arc shape, and its center of circle is respectively positioned on the X-ray source Place;
Described beam-splitting optical grating lower end is provided with micro-displacement stepping mechanism, and described micro-displacement stepping mechanism includes flexible hinge Chain mechanism and drive mechanism, it is in the more of annular shape that the flexure hinge mechanism, which includes rigid plate, is set in the rigid plate, Individual flexible hinge and it is arranged on the flexible hinge periphery and the Flexible hinge being connected with the drive mechanism, the rigid plate It is connected with the beam-splitting optical grating bottom.
Preferably, friction pulley is provided with the turntable, the turntable sidepiece is provided with matches somebody with somebody with the friction pulley The driving wheel of conjunction.
Preferably, the turntable sidepiece is along the circumferential direction additionally provided with multiple steady wheels.
Preferably, it is described it is scanning bed on offer fairshaped groove to lower recess, the groove is in described point Between beam grating and analysis grating.
Preferably, the drive mechanism includes the first drive mechanism and second for being symmetricly set on the rigid plate both ends Drive mechanism, for driving the rigid plate to do movement in a curve under the cooperation of the multiple flexible hinge and Flexible hinge.
Preferably, the turntable is connected with pedestal by cylinder crossed roller bearing.
Preferably, the pedestal includes bottom plate, the inner ring and outer rings being arranged on the bottom plate, is arranged in radiant state Gusset between inner ring and outer shroud.
Preferably, circumferential multiple square holes are offered on the outer wall of the outer shroud of the pedestal.
Preferably, described pedestal lower end is provided with multiple air spring dampers.
Preferably, when the mammary gland phase contrast CT imaging devices carry out breast examination work to patient, its data acquisition Process comprises the following steps:
Step 1:Preset the position of the first collection position, the second collection position, the 3rd collection position and the 4th collection position;
Step 2:The data acquisition of each tomography is carried out to patient's mammary gland position, it is specifically included:
Step 2-1:After patient lies prone is on scanning bed, the fixed beam-splitting optical grating to the described first collection position;
Step 2-2:Control the turntable with the rotating speed rotation of 0.5 cycle per second, the detector with speed of the 2.5ms per frame Rate carries out data acquisition, stops collection after the turntable rotates a circle;
Step 2-3:The beam-splitting optical grating is driven to be moved to the second collection position, weight by the micro-displacement stepping mechanism The multiple step 2-2;
Step 2-4:The beam-splitting optical grating is driven to be moved to the 3rd collection position, weight by the micro-displacement stepping mechanism The multiple step 2-2;
Step 2-5:The beam-splitting optical grating is driven to be moved to the 4th collection position, weight by the micro-displacement stepping mechanism The multiple step 2-2, completes the data acquisition of a tomography to patient's mammary gland position;
Step 3:Control the sample stage to be axially moveable the distance of setting, repeat the step 2, to carry out to patient The data acquisition of next tomography at mammary gland position;
Step 4:Data separating reconstructs:Beam-splitting optical grating in each tomography of the sample gathered by above-mentioned steps is in four Collect 4 groups of data when gathering position are respectively combined as a sets of data, data acquisition.
The beneficial effects of the invention are as follows:The mammary gland phase contrast CT imaging devices of the present invention, clearly mammary gland CT figures can be obtained Picture, and the dose of radiation that patient is received can be substantially reduced, reduce equipment and negatively affected to caused by patient body.The present invention Stability Analysis of Structures is reliable, easy to operate, is well positioned to meet user's request, has wide market prospects.
Brief description of the drawings
Fig. 1 is the structural representation of the mammary gland phase contrast CT imaging devices of the present invention;
Fig. 2 be the present invention mammary gland phase contrast CT imaging devices shed it is scanning bed after structural representation;
Fig. 3 is the top view of the micro-displacement stepping mechanism of the mammary gland phase contrast CT imaging devices of the present invention;
Fig. 4 is the front view of the micro-displacement stepping mechanism of the mammary gland phase contrast CT imaging devices of the present invention;
Fig. 5 is the structural representation of the pedestal of the mammary gland phase contrast CT imaging devices of the present invention.
Description of reference numerals:
1-pedestal;2-scanning bed;3-X-ray source;4-source grating;5-beam-splitting optical grating;6-turntable;7-rub Wipe wheel;8-analysis grating;9-detector;10-driving wheel;11-steady wheel;12-air spring damper;13-microbit Move stepping mechanism;14-rotation steelframe;15-cylinder crossed roller bearing;16-square hole;17-groove;21-drive mechanism; 22-flexure hinge mechanism;101-bottom plate;102-inner ring;103-outer shroud;104-gusset;220-rigid plate;221-soft Property hinge;222-Flexible hinge;2101-the first drive mechanism;2102-the second drive mechanism.
Embodiment
With reference to embodiment, the present invention is described in further detail, to make those skilled in the art with reference to specification Word can be implemented according to this.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein are not precluded from one or more The presence or addition of individual other elements or its combination.
As Figure 1-5, a kind of mammary gland phase contrast CT imaging devices of the present embodiment, including:Pedestal 1, it is arranged on pedestal 1 The turntable 6 of side, the rotation steelframe 14 being arranged on turntable 6 and be erected above rotation steelframe 14 scanning bed 2, rotate steel On frame 14 X-ray source 3, source grating 4, beam-splitting optical grating 5, analysis grating 8 and detector 9 are disposed with along optical path direction;'s Source grating 4, beam-splitting optical grating 5 and analysis grating 8 are arc shape, and its center of circle is respectively positioned at X-ray source 3;Opened up on scanning bed 2 The fairshaped groove 17 of oriented lower recess, groove 17 are between beam-splitting optical grating 5 and analysis grating 8.Groove 17 is used for for suffering from Person's prostrate, make between the mammary gland of patient is between beam-splitting optical grating 5 and analysis grating 8, so that X-ray source 3 is irradiated through entering Row breast examination.
The lower end of beam-splitting optical grating 5 is provided with micro-displacement stepping mechanism 13, micro-displacement stepping mechanism 13 include flexible hinge machine Structure 22 and drive mechanism 21, it is in annular shape that flexure hinge mechanism 22, which includes rigid plate 220, is set in the rigid plate 220, Multiple flexible hinges 221 and be arranged on the periphery of flexible hinge 221 and the flexible hinge being connected with the drive mechanism 21 Plate 222, rigid plate 220 are connected with the bottom of beam-splitting optical grating 5.Drive mechanism 21 includes being arranged on the of the both ends of rigid plate 220 One drive mechanism 210 and the second drive mechanism 211, for driving rigid plate 220 to do arc under the cooperation of multiple flexible hinges 221 Line moves.Flexible hinge 221 is connected with the periphery of rigid plate 220, and Flexible hinge 222 is connected with the periphery of flexible hinge 221, driving Mechanism 21 is connected with Flexible hinge 222.Drive mechanism 21 provides power, and driving Flexible hinge 222 moves, and makes flexible hinge The flexible hinge 221 at the middle part of plate 222 deflects, so that rigid plate 220 does movement in a curve.
Friction pulley 7 is provided with turntable 6, the sidepiece of turntable 6 is provided with the driving wheel 10 coordinated with friction pulley 7.Driving The drive friction pulley 7 of wheel 10 rotates, so as to drive turntable 6 to rotate.The sidepiece of turntable 6 is along the circumferential direction additionally provided with multiple stabilizations Wheel 11.
Rotation steelframe 14 is rotated by rotating mechanism driving.Turntable 6 and pedestal 1 pass through cylinder crossed roller bearing 15 Connection.The lower end of pedestal 1 be provided with multiple air spring dampers 12.
Pedestal 1 includes bottom plate 101, the inner ring 102 being arranged on the bottom plate 101 and outer shroud 103, is arranged in radiant state Gusset 104 between inner ring 102 and outer shroud 103.Circumferential multiple sides are offered on the outer wall of the outer shroud 103 of pedestal 1 Hole 16.
During imaging, the X source of millimeter magnitude is divided into a series of line source by source grating 4 first, to each line source For, its Spatially coherent length at beam-splitting optical grating 5 is more than the cycle of beam-splitting optical grating 5, and such beam-splitting optical grating 5 shines in coherent light Under bright, it can be formed by hooligan's effect in the analysis opening position of grating 8 from imaging.Then by Lau effects, beam-splitting optical grating 5 is each It can mutually stagger a cycle from imaged striation caused by under individual linear light source lighting, be superimposed so as to noncoherent, self-contained The intensity of slice line can greatly be strengthened.Then beam-splitting optical grating 5 from imaged striation and analysis grating 8 can form More's bar Line, if beam-splitting optical grating 5 has a small angle, or beam splitting light between the striped of imaged striation and analysis grating 8 Grid 5 from cycle of imaged striation and analyze grating 8 cycle between small difference be present, then leading to behind analysis grating 8 Cross X-ray detector 9 and can detect cycle very big Moire fringe.Then, X ray can occur when through sample Refraction, the deviation of light can cause the distortion of moire pattern shapes, be embodied in actual tests, be the change of pixel light intensity. By measuring the change of each image pixel intensities, that is, it can obtain the refraction image of sample.
When mammary gland phase contrast CT imaging devices carry out breast examination work to patient, patient lies prone is first allowed on scanning bed 2, is led to X-ray scanning patient's mammary gland position is crossed, data acquisition is carried out, to obtain the CT images of mammary gland.The process of its data acquisition includes Following steps:
Step 1:Preset the position of the first collection position, the second collection position, the 3rd collection position and the 4th collection position;
Step 2:The data acquisition of each tomography is carried out to patient's mammary gland position, it is specifically included:
Step 2-1:After patient lies prone is on scanning bed 2, fixed beam-splitting optical grating 5 to the first gathers position;
Step 2-2:Turntable 6 is controlled to be rotated with the rotating speed of 0.5 cycle per second, control detector 9 is with speed of the 2.5ms per frame Gathered data, turntable 6 stop collection after rotating a circle;
Step 2-3:Beam-splitting optical grating 5 is driven to be moved to the second collection position, repeat step 2- by micro-displacement stepping mechanism 13 2;
Step 2-4:Beam-splitting optical grating 5 is driven to be moved to the 3rd collection position, repeat step 2- by micro-displacement stepping mechanism 13 2;
Step 2-5:Beam-splitting optical grating 5 is driven to be moved to the 4th collection position, repeat step 2- by micro-displacement stepping mechanism 13 2, complete the data acquisition of a tomography of sample;
Step 3:Control sample stage is axially moveable the distance of setting, step 2 is repeated, to carry out next tomography of sample Data acquisition;
Step 4:Data separating reconstructs:Beam-splitting optical grating 5 in each tomography of the sample gathered by above-mentioned steps is in four Collect 4 groups of data during individual collection position are respectively combined as a sets of data, data acquisition.It is follow-up to carry out data point again Reconstructed from CT.
Wherein, arc extended line arrangement of 4 collection positions along curved beam-splitting optical grating 5, i.e., 4 collection positions are with dividing Beam grating 5 is on same circumference, therefore when carrying out data acquisition, beam-splitting optical grating 5 need to be made to do movement in a curve.
Drive mechanism 21 includes the first drive mechanism 2101 and the second drive mechanism 2102, flexible hinge 221 and rigid plate 220 peripheries are connected, and Flexible hinge 222 is connected with the periphery of flexible hinge 221, the first drive mechanism 2101 and the second drive mechanism 2102 are connected with Flexible hinge 222.Drive mechanism 2101 provides motive force, drive mechanism 2102 to Flexible hinge 222 Flexible hinge 222 provides pulling force, and rigid plate 220 is connected by the flexible hinge 221 of multiple circle distributions with Flexible hinge 222 Connect;Two drive mechanisms of control are synchronized with the movement, and Flexible hinge 222 is produced straight-line displacement, so that flexible hinge 221 occurs Deflection, flexible hinge 221 drive rigid plate 220 to do movement in a curve.
Although embodiment of the present invention is disclosed as above, it is not restricted in specification and embodiment listed With it can be applied to various suitable the field of the invention completely, can be easily for those skilled in the art Other modification is realized, therefore under the universal limited without departing substantially from claim and equivalency range, it is of the invention and unlimited In specific details.

Claims (10)

  1. A kind of 1. mammary gland phase contrast CT imaging devices, it is characterised in that including:Pedestal, the turntable being arranged above the pedestal, The rotation steelframe that is arranged on the turntable and it is erected at scanning bed above the rotation steelframe, edge on the rotation steelframe Optical path direction is disposed with X-ray source, source grating, beam-splitting optical grating, analysis grating and detector;
    Described source grating, beam-splitting optical grating and analysis grating is arc shape, and its center of circle is respectively positioned at the X-ray source;
    Described beam-splitting optical grating lower end is provided with micro-displacement stepping mechanism, and described micro-displacement stepping mechanism includes flexible hinge machine Structure and drive mechanism, it is in the multiple soft of annular shape that the flexure hinge mechanism, which includes rigid plate, is set in the rigid plate, Property hinge and the flexible hinge periphery and the Flexible hinge being connected with the drive mechanism are arranged on, the rigid plate and institute State the connection of beam-splitting optical grating bottom.
  2. 2. mammary gland phase contrast CT imaging devices according to claim 1, it is characterised in that friction is provided with the turntable Wheel, the turntable sidepiece are provided with the driving wheel coordinated with the friction pulley.
  3. 3. mammary gland phase contrast CT imaging devices according to claim 2, it is characterised in that the turntable sidepiece is circumferentially square To being additionally provided with multiple steady wheels.
  4. 4. mammary gland phase contrast CT imaging devices according to claim 1, it is characterised in that it is described it is scanning bed on offer downwards The fairshaped groove of depression, the groove are between the beam-splitting optical grating and analysis grating.
  5. 5. mammary gland phase contrast CT imaging devices according to claim 1, it is characterised in that the drive mechanism includes symmetrically setting The first drive mechanism and the second drive mechanism at the rigid plate both ends are put, in the multiple flexible hinge and flexible hinge The rigid plate is driven to do movement in a curve under the cooperation of carrier bar.
  6. 6. mammary gland phase contrast CT imaging devices according to claim 1, it is characterised in that the turntable and pedestal pass through circle Post crossed roller bearing connects.
  7. 7. mammary gland phase contrast CT imaging devices according to claim 1, it is characterised in that the pedestal includes bottom plate, set Inner ring and outer rings on the bottom plate, the gusset being arranged in radiant state between inner ring and outer shroud.
  8. 8. mammary gland phase contrast CT imaging devices according to claim 7, it is characterised in that on the outer wall of the outer shroud of the pedestal Offer circumferential multiple square holes.
  9. 9. mammary gland phase contrast CT imaging devices according to claim 1, it is characterised in that described pedestal lower end is provided with more Individual air spring damper.
  10. 10. mammary gland phase contrast CT imaging devices according to claim 1, it is characterised in that the mammary gland phase contrast CT imagings are set During the standby progress breast examination work to patient, the process of its data acquisition comprises the following steps:
    Step 1:Preset the position of the first collection position, the second collection position, the 3rd collection position and the 4th collection position;
    Step 2:The data acquisition of each tomography is carried out to patient's mammary gland position, it is specifically included:
    Step 2-1:After patient lies prone is on scanning bed, the fixed beam-splitting optical grating to the described first collection position;
    Step 2-2:The turntable is controlled to enter with the rotating speed rotation of 0.5 cycle per second, the detector with speed of the 2.5ms per frame Row data acquisition, stop collection after the turntable rotates a circle;
    Step 2-3:Drive the beam-splitting optical grating to be moved to the second collection position by the micro-displacement stepping mechanism, repeat institute State step 2-2;
    Step 2-4:Drive the beam-splitting optical grating to be moved to the 3rd collection position by the micro-displacement stepping mechanism, repeat institute State step 2-2;
    Step 2-5:Drive the beam-splitting optical grating to be moved to the 4th collection position by the micro-displacement stepping mechanism, repeat institute Step 2-2 is stated, completes the data acquisition of a tomography to patient's mammary gland position;
    Step 3:Control the sample stage to be axially moveable the distance of setting, repeat the step 2, to carry out to patient's mammary gland The data acquisition of next tomography at position;
    Step 4:Data separating reconstructs:Beam-splitting optical grating in each tomography of the sample gathered by above-mentioned steps is in four collections Collect 4 groups of data during position are respectively combined as a sets of data, data acquisition.
CN201710992907.4A 2017-10-23 2017-10-23 Mammary gland phase contrast CT imaging devices Pending CN107714067A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109330621A (en) * 2018-10-19 2019-02-15 深圳市创谷科技发展有限公司 Beam-defining clipper and X-ray machine
CN111714191A (en) * 2020-06-30 2020-09-29 广西医科大学附属肿瘤医院 Laser positioning device for cone beam mammary gland CT guided pendulous puncture

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CN105935297A (en) * 2016-06-23 2016-09-14 中国科学院深圳先进技术研究院 X-ray grating phase-contrast imaging CT system
CN208524886U (en) * 2017-10-23 2019-02-22 中国科学院苏州生物医学工程技术研究所 Mammary gland phase contrast CT imaging device

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Publication number Priority date Publication date Assignee Title
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CN102136300A (en) * 2011-02-10 2011-07-27 南京师范大学 Three-section combined type ultraprecise positioning table and positioning method thereof
CN105120755A (en) * 2013-02-11 2015-12-02 罗切斯特大学 Methods and apparatus for spectral differential phase-contrast cone-beam CT and hybrid cone-beam CT
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109330621A (en) * 2018-10-19 2019-02-15 深圳市创谷科技发展有限公司 Beam-defining clipper and X-ray machine
CN111714191A (en) * 2020-06-30 2020-09-29 广西医科大学附属肿瘤医院 Laser positioning device for cone beam mammary gland CT guided pendulous puncture

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