CN105920389A - Traditional Chinese medicinal composition for treating hoove and preparation of traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition for treating hoove and preparation of traditional Chinese medicinal composition Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention relates to a traditional Chinese medicinal composition for treating hoove and a preparation method of a preparation of the traditional Chinese medicinal composition. The preparation method comprises the following steps: (1) smashing melanterite till the powder with grain size being 10 meshes or above or superfine powder is obtained; (2) adding water into wheat, boiling till the boiling state, after 5-30 min, carrying out warm immersion for 1-5 times, mixing the immersion liquid, filtering the mixed immersion liquid, concentrating the filtrate to obtain diluted paste, adding water into fructus ziziphi jujubae, radix aucklandiae and radix kansui, carrying out extraction for 1-5 times (each time lasts for 0.1-5 h), mixing the medicinal liquid, filtering the obtained mixed medicinal liquid, concentrating the filtrate, mixing the obtained paste with the wheat diluted paste, and concentrating the obtained mixed paste to obtain an extract with the relative density being 1.00-1.60; and (3) mixing the powder and the extract to obtain a product taken as the medicinal active ingredient, and preparing the medicinal preparation composition by adopting the medicinal active ingredient according to the conventional pharmaceutics method.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition, particularly to a kind of Chinese medicine composition treating hoove
And preparation.
Background technology:
Distension disease, is the traditional Chinese medical science general designation to diseases such as various Pleural effusions, oedema, edema, with thorax abdomen tympanites
Name such as drum, swell with belly, the colour of skin is greenish yellow, belly train of thought exposes as feature.Distension disease root
Being divided into according to the difference of etiology and pathogenesis " distention of the abdomen caused by accumulation of gas due to dysfunction of the spleen or to emotional factors, blood distension, ascites ", the distension disease of traditional medicine is general
Referring to all diseases with oedema as main clinical manifestation, these syndromes are by liver, lung, the heart, kidney
By disease, in gas, blood, water alluvial abdomen, it is impossible to discharged by health excretory function, so that chest
Belly swells day by day, ultimately forms tympanites.
Drug main its prescription of ascites pill to be had of existing treatment distension disease is melanterite (vinegar system), the root of gansui, date
(stoning stir-fry), the banksia rose etc..Existing ascites pill is the sugar-coat water-bindered pill, aobvious brown after removing sugar-coat；Taste
Sour, puckery.Its discrimination method is as follows: take this product 1g, removes sugar-coat, and finely ground, add water 10ml,
Boil 10 minutes, filter, take filtrate 1ml, add iron potassuim cyanide test liquid 2～3, i.e. generate
Blue precipitate, separates, and is deposited in watery hydrochloric acid insoluble, and hydro-oxidation sodium test solution, in brown
Precipitation.
Its function cures mainly as follows: inducing diuresis for removing edema, and dehumidify invigorating the spleen.For distension disease, fullness and oppression of chest and abdomen, four limbs
Edema, constipation, scanty drak urine.
Traditional Chinese medicine ingredients effect in ascites pill is as follows:
Date: another name red date, dry jujube, Chinese date, for Rhamnaceae thing jujube Ziziphus jujuba Mill.
Dry mature fruit.
Melanterite: another name green vitriol, green alum.This product is the ore of Sulfates fossil water green vitriol.Master contains
Aqueous ferrous sulfate (FeSO4·7H2O), after excavating, miscellaneous stone is removed.
The root of gansui: call main field, Chong Ze, sweet ligusticumic, mound ligusticumic, Gan Ze, bitter pool, Bai Ze, ugly, the mound of ghost
Pool.This product is euphorbia plant root of gansui Euphorbia kansui T.N.Liou ex T.P.Wang
Dried root.
The banksia rose: another name honey perfume, dutchmanspipe root, spices, five banksia rose.This product is the feverfew banksia rose
The dry root of Aucklandia lappa Decne..
Wheat: another name bran wheat, swimmer, light wheat, absolutely empty wheat, the soft grain of wheat, wheat.For grass family
The dry mature fruit of plant wheat Triticum aestivum L..
Prior art discloses the following relevant information of ascites pill
Ascites pill is " Drug Standard of Ministry of Public Health of the Peoples Republic of China " Traditional Chinese medicine historical preparation second receipts
The medicine carried, is clinical conventional Chinese patent drug, by five tastes such as melanterite (vinegar system), the root of gansui, dates
Medicine forms.Have inducing diuresis for removing edema, dehumidifying invigorating the spleen effect, be mainly used in distension disease, fullness and oppression of chest and abdomen,
The symptoms such as four limbs edema, constipation, scanty drak urine.Ascites pill quality standard record in " in
People's republic of China the Sanitation Ministry medicine standard " Traditional Chinese medicine historical preparation second.Content is as follows:
[prescription] melanterite (vinegar system) 200g root of gansui 20g date (stoning stir-fry) 200g banksia rose 20g
Wheat (stir-fry) 100g
[preparation method] above five tastes, are ground into fine powder, sieve, mixing；With water pill, less than 60 DEG C
It is dried, sugar coating, to obtain final product.[proterties] this product is the sugar-coat water-bindered pill, aobvious brown after removing sugar-coat；
Taste is sour, puckery.[function with cure mainly] inducing diuresis for removing edema, dehumidify invigorating the spleen.For distension disease, chest and abdomen are swollen
Full, four limbs edema, constipation, scanty drak urine.[usage and consumption] is before meals, once
10,3 times on the one, children are cut down according to the circumstance.[attention] can not avoid salt and mustard with Radix Glycyrrhizae with clothes
Wheat face.[specification] every 10 weight 1.3g[storages] seal, moistureproof.
Following Chinese patent describes method of quality control
| 200810056503.5 | Ascites pill and the quality standard of preparation thereof and detection method |
| 201110222362.1 | Ascites pill and the quality standard of preparation thereof and detection method |
The present inventor finds in production practices clinical, and prior art is at curative effect, stability, raw material
The aspect such as saving need to improve, to improve the effect of medicine, extend shelf life, reduce medicine
Usage amount, improve medicine adaptability, for this present inventor, prior art is improved,
Thus complete the present invention.
Summary of the invention:
For improving the defect of prior art, the present invention provides the new preparation method of a kind of ascites pill, this
Inventing described ascites pill, its formula is as follows:
Ascites pill described in preferred invention, its formula is as follows:
Composition described above is by weight as proportioning, can increase according to corresponding proportion when producing or subtract
Few, as large-scale production can by kilogram in units of, or in units of ton, small-scale production is also
Can be in units of milligram, weight can increase or reduce, but the raw medicinal herbs between each composition
The constant rate of weight proportion.
The ratio of above weight proportion obtains, for special circumstances, such as severe through science screening
Or mild, fat or modest, the proportioning of the amount of composition can be adjusted accordingly, be increased or decreased
Less than 100%, drug effect is constant.
Single medicinal material in composition described above, especially ministerial drug and adjutant, it is also possible to be there is phase by suitable
Replacing with the Chinese medicine of the property of medicine, its medicine effect of the Chinese medicine preparation after replacement is constant.
The ascites pill Chinese medicine preparation composition of the present invention, is the Chinese medicine material by being formed by above-mentioned formula
Through work, make pharmaceutically active substance, subsequently, with this material as raw material, add when needing and be used as medicine
Thing acceptable carrier, makes according to the routine techniques of galenic pharmacy.
The pharmaceutically active substance of the present invention, its in the formulation shared percentage by weight can be
0.1-99.9%, remaining is pharmaceutically acceptable carrier.The pharmaceutical preparations composition of the present invention,
Existing in a unit, described unit dosage form refers to the unit of preparation, such as tablet
Every, every seed lac capsule of capsule, every bottle of oral liquid, granule every bag etc..
The Chinese medicine preparation composition of the present invention can be any pharmaceutically useful formulation, and these formulations include:
Tablet, capsule, granule, pill, powder, paste, sublimed preparation, pulvis, solution,
Injection, suppository, spray, drops, patch.The preparation of the present invention, the most oral
Formulation, such as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, cream
Agent etc..
The Chinese medicine preparation composition of the present invention, the preparation of its oral administration can contain conventional excipient,
Such as adhesive, filler, diluent, tablet agent, lubricant, disintegrant, colouring agent,
Flavor enhancement and wetting agent.
The filler being suitable for includes the filler that cellulose, mannitol, lactose are similar with other.Suitable
Suitable disintegrant includes starch, polyvinylpyrrolidone and starch derivatives, such as hydroxyacetic acid
Sodium starch.Suitable lubricant includes, such as magnesium stearate.Suitable is pharmaceutically acceptable wet
Profit agent includes lauryl sodium sulfate.
Can be filled by mixing, the method that compressing tablet etc. is commonly used prepares solid oral composition.Carry out anti-
Compound closes and can make in those compositions that active material is distributed in a large amount of filler of whole use.
The form of oral liquid can be such as aqueous or oily suspensions, solution, emulsion, sugar
Slurry agent or elixir, or can be a kind of available water before use or other suitable carrier compounds
Dry products.This liquid preparation can be containing conventional additive, such as suspending agent, such as
Sorbierite, syrup, methylcellulose, gelatin, hydroxyethyl cellulose, carboxymethylcellulose calcium,
Aluminium stearate gel or hydrogenated edible fats, emulsifying agent, such as lecithin, anhydro sorbitol one
Oleate or Arabic gum；Non-aqueous carrier (they can include edible oil), such as almond
Oil, the oily ester of ester, propane diols or the ethanol of fractionated coconut oil, such as glycerine；Preservative,
Such as para hydroxybenzene methyl esters or propylparaben or sorbic acid, and if it is required, can
Containing conventional flavouring agent or colouring agent.
The Chinese medicine preparation composition of the present invention, optionally adds applicable medicine when being prepared as medicament
Thing acceptable carrier, the adjunct ingredient as conventional: mannitol, sorbierite, sodium pyrosulfite,
Sodium hydrogensulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, dimension are raw
Element C, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphoric acid
Salt or its aqueous solution, hydrochloric acid, acetic acid, sulfuric acid, phosphoric acid, amino acid, sodium chloride, potassium chloride,
Sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch,
Sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginates, bright
Glue, polyvinylpyrrolidone, glycerine, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate,
Surfactant, polyethylene glycol, cyclodextrin, beta-schardinger dextrin, phospholipid material, kaolin,
Talcum powder, calcium stearate, magnesium stearate etc..
The preparation compositions of the present invention determines usage and dosage according to condition in use, can often taken three times per day,
1-20 agent every time, such as: 1-20 bag or grain or sheet.
The present invention further provides the preparation method of preparation compositions of the present invention, described method step
As follows:
1), melanterite is ground into the 10 above powder of mesh to impalpable powder；；
2), after wheat adds water boil 5-30 minute, temperature leaching 1-5 time, merge immersion liquid, filter, filter
Liquid is condensed into dilute cream, date, the banksia rose, root of gansui extracting in water 1-5 time, and each 0.1-5h closes
And liquid filters, concentrate, merge the dilute cream of wheat and be concentrated into the medicinal extract of relative density 1.00-1.60；
3) powder mix with medicinal extract, as active constituents of medicine, root galenic pharmacy conventional method makes medicine
Thing preparation compositions.
Preferably, described preparation method, step is as follows:
1), melanterite is ground into the 10 above powder of mesh to impalpable powder；；
2), after wheat adds water boil 10-20 minute, temperature leaching 1-3 time, merge immersion liquid, filter, filter
Liquid is condensed into dilute cream, date, the banksia rose, root of gansui extracting in water 1-3 time, and each 0.5-3h closes
And liquid filters, concentrate, merge the dilute cream of wheat and be concentrated into the medicinal extract of relative density 1.00-1.60；
3) powder mix with medicinal extract, as active constituents of medicine, root galenic pharmacy conventional method makes medicine
Thing preparation compositions.
Particularly preferred, described preparation method, step is as follows:
1), melanterite is ground into the 10 above powder of mesh to impalpable powder；；
2), after wheat adds water boil 15 minutes, temperature leaching 2-3 time, merge immersion liquid, filtration, filtrate
It is condensed into dilute cream, date, the banksia rose, root of gansui extracting in water 2-3 time, each 2-3h, merge medicine
Liquid filters, and concentrates, and merges the dilute cream of wheat and is concentrated into the medicinal extract of relative density 1.00-1.60；
3) powder mix with medicinal extract, as active constituents of medicine, root galenic pharmacy conventional method makes medicine
Thing preparation compositions.
Compared to the prior art, main active substantially increases the method for the present invention, and drug effect substantially carries
Height, preparation stability significantly improves,
Below by way of experimental data beneficial effects of the present invention is described:
Experiment content:
The present invention and prior art carry out contrast experiment
1, drug effect contrast experiment:
This research is intended to be evaluated medicine of the present invention with rat hepatocirrhosis Ascites Model
CCl4Preparation Hepatocirrhosis Model, is administered according to the weight of animals, often with 50% miscella solution
Week 2 times, 12-15 week can form cirrhosis, prepares rat hepatocirrhosis Ascites Model, and modeling becomes
Drug administration and physiological saline after merit, and body weight, abdominal circumference are measured.
Rat model is randomly divided into three groups: be administered before measure the body weight of rat, abdominal circumference, be then divided into
Lower group: model blank control rats gives normal diet, of the present invention group of dosage is
2.0g/kg, prior art group dosage is 2.0g/kg, is taken twice daily, totally 7 days.
Measuring the body weight of rat, abdominal circumference after being administered after 7 days, carry out statistical analysis, comparison therapy is imitated
Really, wherein dosage 2.0g/kg according to raw medicine calculation.(n=10,)
Result shows, of the present invention group and prior art group parameters index variable quantity and negative control group
Relatively, having an obvious significant difference, of the present invention group and prior art group compare, the present invention
Group is substantially better than prior art group in effect.
2, clinical laboratory data
Selecting 50 hepatitis, the patient of cirrhotic ascites, as treatment target, is divided into 2 groups at random,
Using the Chinese medicine composition of the present invention to treat the patient of experimental group, the patient of control group makes
Treat with prior art ascites pill.The clinical treatment of the Chinese medicine composition of the present invention is seen
Examine, the medicine of the employing present invention and the result for the treatment of table of prior art ascites pill:
| Group | n | Effective | Effectively | Invalid | Efficient |
| The present invention | 25 | 11 | 12 | 2 | 92% |
| Existing medicine | 25 | 10 | 12 | 3 | 88% |
Criterion of therapeutical effect:
Effective: ascites and constitutional symptom are alleviated or disappear, and liver function recovers normal substantially.
Effective: ascites and other symptoms are clearly better, and laboratory examination has improvement.
Invalid: ascites has no and alleviates, other symptoms and liver function are without improving or deteriorating.
Clinical test results shows: 2 groups of total effective rates compare, and difference has significant, this
Bright group is better than ascites pill group (P ＜ 0.05).
3, medicine stability experiment:
Sample is placed on 40 DEG C ± 2 DEG C, to be positioned over constant temperature under conditions of relative humidity 75% ± 5% permanent
In wet tank, to set time sampling, relevant composition is carried out assay, preliminary after test
Stability test result is as follows:
Primary stability result of the test after inventive samples test
Primary stability result of the test after prior art sampling test
Result shows that stability of the present invention is higher.
4, main component Dissolution experiments
Assay method: by Chinese Pharmacopoeia dissolution method (slurry processes), with 900ml degassing purified water
For dissolution medium, temperature 37+0.5 DEG C, regulate rotating speed 100r/min, take 6 parts of sample, accurate
Weighed it is placed in stripping rotor, respectively at 10min, 20min, 30min, 40min, 50min,
Sample 2ml during 60min, add equality of temperature medium 2ml simultaneously, centrifugal, measure ferrous sulfate
Dissolution rate.
Take the embodiment of the present invention 1 pill and each 6 balls of commercially available pill individually below, survey it at different time
The dissolution rate of active ingredient ferrous sulfate, result see table.
The pill different time dissolution determination data that the embodiment of the present invention 1 method prepares
Commercially available pill different time dissolution determination data
From above experimental data it can be seen that with the embodiment of the present invention 1 method prepare pill, medicine
In water readily soluble, the dissolution rate of medicament effective component is greatly improved, thus improves the biology of medicine
Availability.
Detailed description of the invention:
Further illustrate the present invention by the following examples, but not as limitation of the present invention.
Embodiment 1
[prescription]
Melanterite (vinegar system) 200g
Root of gansui 20g
Date (stoning stir-fry) 200g
Banksia rose 20g
Wheat (stir-fry) 100g
[preparation method]
1), melanterite is ground into the 10 above powder of mesh to impalpable powder；；
2), after wheat adds water boil 5 minutes, temperature leaching 3 times, merge immersion liquid, filter, filtrate concentrates
Become dilute cream, date, the banksia rose, root of gansui extracting in water 3 times, each 2h, merge liquid and filter,
Concentrate, merge the dilute cream of wheat and be concentrated into the medicinal extract of relative density 1.00-1.60；
3-1), powder mixes with medicinal extract, pelletizes, is dried and makes condensed pill (the concentration water-bindered pill, concentration honey
Ball, condensed water honeyed bolus)；
3-2), powder mix with medicinal extract, pelletize or pill, be dried make capsule or tablet.
3-3), powder mix with medicinal extract, add appropriate flavouring, pelletize, be dried, whole grain, system
Become granule.
3-4), powder mix with medicinal extract, add appropriate auxiliary material, mixing, make soft capsule or dripping pill.
3-5), powder mix with medicinal extract, be dried, make powder.
Embodiment 2
[prescription]
[preparation method]
1), melanterite is ground into the 10 above powder of mesh to impalpable powder；；
2), after wheat adds water boil 20 minutes, temperature leaching 2 times, merge immersion liquid, filter, filtrate is dense
Shorten dilute cream into, date, the banksia rose, root of gansui extracting in water 2 times, each 3h, merge liquid filter
Cross, concentrate, merge the dilute cream of wheat and be concentrated into the medicinal extract of relative density 1.30-1.60；
3-1), powder mixes with medicinal extract, pelletizes, is dried and makes condensed pill (the concentration water-bindered pill, concentration honey
Ball, condensed water honeyed bolus)；
3-2), powder mix with medicinal extract, pelletize or pill, be dried make capsule or tablet.
3-3), powder mix with medicinal extract, add appropriate flavouring, pelletize, be dried, whole grain, system
Become granule.
3-4), powder mix with medicinal extract, add appropriate auxiliary material, mixing, make soft capsule or dripping pill.
3-5), powder mix with medicinal extract, be dried, make powder.
Embodiment 3
[prescription]
[preparation method]
1), melanterite is ground into the 10 above powder of mesh to impalpable powder；；
2), after wheat adds water boil 15 minutes, temperature leaching 4 times, merge immersion liquid, filter, filtrate is dense
Shorten dilute cream into, date, the banksia rose, root of gansui extracting in water 4 times, each 1h, merge liquid filter
Cross, concentrate, merge the dilute cream of wheat and be concentrated into the medicinal extract of relative density 1.00-1.30；
3-1), powder mixes with medicinal extract, pelletizes, is dried and makes condensed pill (the concentration water-bindered pill, concentration honey
Ball, condensed water honeyed bolus)；
3-2), powder mix with medicinal extract, pelletize or pill, be dried make capsule or tablet.
3-3), powder mix with medicinal extract, add appropriate flavouring, pelletize, be dried, whole grain, system
Become granule.
3-4), powder mix with medicinal extract, add appropriate auxiliary material, mixing, make soft capsule or dripping pill.
3-5), powder mix with medicinal extract, be dried, make powder.
Claims (4)
1. a preparation method for ascites pill, described ascites pill, its formula is as follows:
Described preparation method, step is as follows:
1), melanterite is ground into the 10 above powder of mesh to impalpable powder；；
2), after wheat adds water boil 5-30 minute, temperature leaching 1-5 time, merge immersion liquid, filter, filter
Liquid is condensed into dilute cream, date, the banksia rose, root of gansui extracting in water 1-5 time, and each 0.1-5h closes
And liquid filters, concentrate, merge the dilute cream of wheat and be concentrated into the medicinal extract of relative density 1.00-1.60；
3) powder mix with medicinal extract, as active constituents of medicine, root galenic pharmacy conventional method makes medicine
Thing preparation compositions.
Preparation method the most according to claim 1, wherein said ascites pill, its formula is as follows:
Described preparation method, step is as follows:
1), melanterite is ground into the 10 above powder of mesh to impalpable powder；；
2), after wheat adds water boil 10-20 minute, temperature leaching 1-3 time, merge immersion liquid, filter, filter
Liquid is condensed into dilute cream, date, the banksia rose, root of gansui extracting in water 1-3 time, and each 0.5-3h closes
And liquid filters, concentrate, merge the dilute cream of wheat and be concentrated into the medicinal extract of relative density 1.00-1.60；
3) powder mix with medicinal extract, as active constituents of medicine, root galenic pharmacy conventional method makes medicine
Thing preparation compositions.
Preparation method the most according to claim 1, wherein said ascites pill, its formula is as follows:
Described preparation method, step is as follows:
1), melanterite is ground into the 10 above powder of mesh to impalpable powder；；
2), after wheat adds water boil 15 minutes, temperature leaching 2-3 time, merge immersion liquid, filtration, filtrate
It is condensed into dilute cream, date, the banksia rose, root of gansui extracting in water 2-3 time, each 2-3h, merge medicine
Liquid filters, and concentrates, and merges the dilute cream of wheat and is concentrated into the medicinal extract of relative density 1.00-1.60；
3) powder mix with medicinal extract, as active constituents of medicine, root galenic pharmacy conventional method makes medicine
Thing preparation compositions.
Preparation method the most according to claim 1, wherein said ascites pill, its formula is as follows:
Described preparation method, step is as follows:
1), melanterite is ground into the 10 above powder of mesh to impalpable powder；；
2), after wheat adds water boil 20 minutes, temperature leaching 3 times, merge immersion liquid, filter, filtrate is dense
Shorten dilute cream into, date, the banksia rose, root of gansui extracting in water 3 times, each 2h, merge liquid filter
Cross, concentrate, merge the dilute cream of wheat and be concentrated into the medicinal extract of relative density 1.00-1.60；
3-1), powder mixes with medicinal extract, pelletizes, is dried and makes condensed pill (the concentration water-bindered pill, concentration honey
Ball, condensed water honeyed bolus)；
3-2), powder mix with medicinal extract, pelletize or pill, be dried make capsule or tablet.
3-3), powder mix with medicinal extract, add appropriate flavouring, pelletize, be dried, whole grain, system
Become granule.
3-4), powder mix with medicinal extract, add appropriate auxiliary material, mixing, make soft capsule or dripping pill.
3-5), powder mix with medicinal extract, be dried, make powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610281879.0A CN105920389A (en) | 2016-04-28 | 2016-04-28 | Traditional Chinese medicinal composition for treating hoove and preparation of traditional Chinese medicinal composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610281879.0A CN105920389A (en) | 2016-04-28 | 2016-04-28 | Traditional Chinese medicinal composition for treating hoove and preparation of traditional Chinese medicinal composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105920389A true CN105920389A (en) | 2016-09-07 |
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| CN201610281879.0A Pending CN105920389A (en) | 2016-04-28 | 2016-04-28 | Traditional Chinese medicinal composition for treating hoove and preparation of traditional Chinese medicinal composition |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1440772A (en) * | 2003-04-08 | 2003-09-10 | 邯郸制药有限公司 | Composite Chinese medicine for treating bloat and its prepn process and quality control method |
| CN101229248A (en) * | 2008-01-21 | 2008-07-30 | 邯郸制药有限公司 | Quality standard and test method of hoove pill and preparation threrewith |
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- 2016-04-28 CN CN201610281879.0A patent/CN105920389A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1440772A (en) * | 2003-04-08 | 2003-09-10 | 邯郸制药有限公司 | Composite Chinese medicine for treating bloat and its prepn process and quality control method |
| CN101229248A (en) * | 2008-01-21 | 2008-07-30 | 邯郸制药有限公司 | Quality standard and test method of hoove pill and preparation threrewith |
Non-Patent Citations (3)
| Title |
|---|
| 孙世光等: "《新编医院药学》", 31 March 2010, 北京军事医学科学出版社 * |
| 贾水莲等: "中药成方制剂治疗肝硬化的品种概况", 《浙江中医药大学学报》 * |
| 鞠玲卉: "中成药制剂治疗肝硬化的品种分析", 《亚太传统医药》 * |
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Application publication date: 20160907 |