CN105920227B - A kind of preparation method of west safflower medicine materical crude slice - Google Patents
A kind of preparation method of west safflower medicine materical crude slice Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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Abstract
The invention discloses a kind of preparation methods of west safflower medicine materical crude slice.The preparation method includes the following steps: drying: west safflower raw material being laid in canister, is dried by the vapor heating metal container that water-bath generates, and is spaced and stirs, obtains semi-finished product 1；The temperature of the water-bath is 60~80 DEG C；Humidification: semi-finished product 1 are laid in the porose container in bottom, and the vapor that water-bath generates humidifies semi-finished product 1 through hole, to obtain semi-finished product 2；The temperature of the water-bath is 85~88 DEG C；Redrying: semi-finished product 2 are laid in canister again, are dried by the vapor heating metal container that water-bath generates, and are spaced and are stirred；The temperature of the water-bath is 60~80 DEG C.Effective component crocin I, crocin II content are higher in west safflower medicine materical crude slice produced by the present invention, and obtained medicine materical crude slice flower-shape appearance looks elegant, meet consumption demand of the market to west safflower medicine materical crude slice.
Description
Technical field
The present invention relates to Chinese medicine processing technique field more particularly to a kind of preparation methods of west safflower medicine materical crude slice.
Background technique
The cultivar of west safflower Shu Ying tail section crocus, Classification system Crocus Sativus L. also known as safron,
Safflower removes fragrance is blue, moors husband orchid etc., is herbaceos perennial.
West safflower is used as medicine with gynoecium top column cap, sweet in flavor mild-natured, has activating microcirculation and removing stasis medicinal, removing pattogenic heat from the blood and toxic material from the body, resolving stagnation for tranquilization drug effect.West
The style and column cap of safflower contain several safron glycosides and bayer acid dimethyl ester, safron hardship glycosides etc., another 0.4- containing volatile oil
1.3%, main component is safranal, additionally containing rhamnetin, Kaempferol etc..
It is well known that the superiority and inferiority of prepared slices of Chinese crude drugs clinical therapeutic efficacy is directly closely related with its active constituent content height,
West safflower curative effect is no exception.But the common oven drying method of the prior art not only reduces west safflower active constituent content, but also
Destroy medicine materical crude slice mode of appearance.Although patent document CN201310003571.6 increases to west safflower active constituent content,
Still it is unable to improve medicine materical crude slice mode of appearance.This seriously restricts clinical efficacy of medicine materical crude slice and market to the acceptance level of product, especially
It is west safflower as health care product gift sales and does not meet target market more to the high standard of its active constituent content and appearance.
Summary of the invention
Technical problem to be solved by the present invention lies in overcome west safflower medicine materical crude slice to process effective component of the existing technology
Content is low, medicine materical crude slice aesthetic appearance difference defect, provides a kind of preparation method of west safflower medicine materical crude slice.West made from the preparation method
Effective component crocin I, crocin II content are higher in safflower medicine materical crude slice, up to 24% or more, are above the prior art, and add
Construction equipment is low in cost, easy to operate；And obtained medicine materical crude slice flower-shape appearance looks elegant, compared with prior art further satisfaction target
Consumption demand of the market to west safflower medicine materical crude slice.
The present invention solves above-mentioned technical problem by following technical proposals:
The present invention provides a kind of preparation methods of west safflower medicine materical crude slice comprising following step:
(1) dry: west safflower raw material to be laid in canister, the vapor heating metal container generated by water-bath
It is dried, and is spaced and stirs, obtain semi-finished product 1；The temperature of the water-bath is 60~80 DEG C；
(2) it humidifies: semi-finished product 1 is laid in the porose container in bottom, the vapor that water-bath generates is through hole humidification half
Finished product 1, to obtain semi-finished product 2；The temperature of the water-bath is 85~88 DEG C；
(3) redrying: semi-finished product 2 are laid in canister again, heat metal by the vapor that water-bath generates
Container is dried, and is spaced and stirs；The temperature of the water-bath is 60~80 DEG C.
Wherein, the west safflower raw material in the present invention is generally commercially available.
In step (1), the canister is preferably rustless steel container；The thickness of the tiling is preferably
0.3~0.8cm is more preferably 0.3~0.5cm.
In step (1), the temperature of the water-bath is preferably 65~70 DEG C, is more preferably 70 DEG C.
In step (1), the time of the drying is preferably 10~20 minutes.
In step (1), the time interval that the interval is stirred is preferably 3~5 minutes.
In step (2), the mesh number in the hole is preferably 4~18 mesh.
In step (2), the time of the humidification is preferably 3~5 minutes.
In step (3), the canister is preferably rustless steel container；The thickness of the tiling is preferably
0.3~0.8cm is more preferably 0.3~0.5cm.
In step (3), the temperature of the water-bath is preferably 65~70 DEG C, is more preferably 70 DEG C.
In step (3), the time of the drying is preferably 10~20 minutes.
In step (3), the time interval that the interval is stirred is preferably 3~5 minutes.
On the basis of common knowledge of the art, above-mentioned each optimum condition, can any combination to get each preferable reality of the present invention
Example.
The reagents and materials used in the present invention are commercially available.
The positive effect of the present invention is that:
(1) effective component crocin I, crocin II content in west safflower medicine materical crude slice made from preparation method of the invention
It is higher, up to 24% or more, it is above the prior art.
(2) fragranced specific to west safflower medicine materical crude slice produced by the present invention is denseer, the content of safranal up to 0.6% with
On.
(3) the medicine materical crude slice flower-shape appearance looks elegant that the present invention obtains, does not crimp, compared with prior art further satisfaction target
Consumption demand of the market to west safflower medicine materical crude slice as gift.
(4) tooling cost of the invention is cheap, easy to operate.
Detailed description of the invention
Fig. 1 is the appearance photo of west safflower medicine materical crude slice produced by the present invention.
Fig. 2 is the appearance photo of west safflower medicine materical crude slice made from comparative example 1,2
Specific embodiment
The present invention is further illustrated below by the mode of embodiment, but does not therefore limit the present invention to the reality
It applies among a range.In the following examples, the experimental methods for specific conditions are not specified, according to conventional methods and conditions, or according to quotient
The selection of product specification.
Percentage in following embodiments is mass percent.
Embodiment 1
(1) west safflower laid in metal (stainless steel) container, spread flower with a thickness of 0.5cm, canister passes through water-bath and produces
Raw vapor heating, the temperature of water-bath are 70 DEG C, are spaced and are stirred within 5 minutes once in heating process, heating time 20 minutes.
(2) it humidifies: the semi-finished product that step (1) obtains is laid in the porose container in bottom (mesh number in hole is 10 mesh),
The vapor that water-bath generates humidifies 3 minutes through hole；The temperature of the water-bath is 88 DEG C；
(3) redrying: repeat the above steps (1).
The flower good appearance of west safflower medicine materical crude slice made from the present embodiment, for dry column cap without curling in thin-line-shaped, top is wider
Greatly, tapered downwards is in shape of tail, rufous.Dry west safflower is packed into plastic film bag, every bag of 50mg.
Finished product is set and is stored at shady and cool drying.It is separately sampled in 0,12,24 month, by 2015 editions Chinese Pharmacopoeias (one) west safflower
Regulation detection under, as a result crocin I and crocin II total amount are respectively 26%, 20%, 18%.
West safflower medicine materical crude slice obtained have denseer special fragranced, show that safranal content is more, by it is ultraviolet-can
The content of safranal is 0.62% in light-exposed spectrometer detection medicine materical crude slice.
The appearance photo of west safflower medicine materical crude slice made from the embodiment is shown in Fig. 1.
Embodiment 2
(1) west safflower laid in metal (stainless steel) container, spread flower with a thickness of 0.5cm, canister passes through water-bath and produces
Raw vapor heating, the temperature of water-bath are 75 DEG C, are spaced and are stirred within 3 minutes once in heating process, heating time 15 minutes.
(2) it humidifies: the semi-finished product that step (1) obtains is laid in the porose container in bottom (mesh number in hole is 18 mesh),
The vapor that water-bath generates humidifies 4 minutes through hole；The temperature of the water-bath is 86 DEG C；
(3) redrying: repeat the above steps (1).
The flower good appearance of west safflower medicine materical crude slice made from the present embodiment, for dry column cap without curling in thin-line-shaped, top is wider
Greatly, tapered downwards is in shape of tail, rufous.Dry west safflower is packed into plastic film bag, every bag of 50mg.
Finished product is set and is stored at shady and cool drying.It is separately sampled in 0,12,24 month, by 2015 editions Chinese Pharmacopoeias (one) west safflower
Regulation detection under, as a result crocin I and crocin II total amount are respectively 24%, 22%, 20%.
West safflower medicine materical crude slice obtained have denseer special fragranced, show that safranal content is more, by it is ultraviolet-can
The content of safranal is 0.63% in light-exposed spectrometer detection medicine materical crude slice.
The appearance photo of west safflower medicine materical crude slice made from the embodiment is shown in Fig. 1.
Embodiment 3
(1) west safflower laid in metal (stainless steel) container, spread flower with a thickness of 0.5cm, canister passes through water-bath and produces
Raw vapor heating, the temperature of water-bath are 80 DEG C, are spaced and are stirred within 4 minutes once in heating process, heating time 17 minutes.
(2) it humidifies: the semi-finished product that step (1) obtains is laid in the porose container in bottom (mesh number in hole is 4 mesh), water
The vapor that bath generates humidifies 5 minutes through hole；The temperature of the water-bath is 85 DEG C；
(3) redrying: repeat the above steps (1).
The flower good appearance of west safflower medicine materical crude slice made from the present embodiment, for dry column cap without curling in thin-line-shaped, top is wider
Greatly, tapered downwards is in shape of tail, rufous.Dry west safflower is packed into plastic film bag, every bag of 50mg.
Finished product is set and is stored at shady and cool drying.It is separately sampled in 0,12,24 month, by 2015 editions Chinese Pharmacopoeias (one) west safflower
Regulation detection under, as a result crocin I and crocin II total amount are respectively 25%, 22%, 20%.
West safflower medicine materical crude slice obtained have denseer special fragranced, show that safranal content is more, by it is ultraviolet-can
The content of safranal is 0.62% in light-exposed spectrometer detection medicine materical crude slice.
The appearance photo of west safflower medicine materical crude slice made from the embodiment is shown in Fig. 1.
Embodiment 4
(1) west safflower laid in metal (stainless steel) container, spread flower with a thickness of 0.4cm, canister passes through water-bath and produces
Raw vapor heating, the temperature of water-bath are 79 DEG C, are spaced and are stirred within 4 minutes once in heating process, heating time 10 minutes.
(2) it humidifies: the semi-finished product that step (1) obtains is laid in the porose container in bottom (mesh number in hole is 15 mesh),
The vapor that water-bath generates humidifies 4 minutes through hole；The temperature of the water-bath is 86 DEG C；
(3) redrying: repeat the above steps (1).
The flower good appearance of west safflower medicine materical crude slice made from the present embodiment, for dry column cap without curling in thin-line-shaped, top is wider
Greatly, tapered downwards is in shape of tail, rufous.Dry west safflower is packed into plastic film bag, every bag of 50mg.
Finished product is set and is stored at shady and cool drying.It is separately sampled in 0,12,24 month, by 2015 editions Chinese Pharmacopoeias (one) west safflower
Regulation detection under, as a result crocin I and crocin II total amount are respectively 26%, 21%, 20%.
West safflower medicine materical crude slice obtained have denseer special fragranced, show that safranal content is more, by it is ultraviolet-can
The content of safranal is 0.63% in light-exposed spectrometer detection medicine materical crude slice.
The appearance photo of west safflower medicine materical crude slice made from the embodiment is shown in Fig. 1.
Comparative example 1
Using the dry west safflower of commercial microwave furnace, flower thickness 0.4cm is spread, 90 DEG C of temperature, interval is stirred once for 3 minutes, when
Between 15 minutes.
The flower shape curling of product made from this example.Dry west safflower is packed into plastic film bag, every bag of 50mg.
Finished product is set and is stored at shady and cool drying.It is separately sampled in 0,12,24 month, by 2015 editions Chinese Pharmacopoeias (one) west safflower
Regulation detection under, as a result crocin I and crocin II total amount are respectively 20%, 18%, 18%.
West safflower medicine materical crude slice obtained only has very light special fragranced, shows that safranal content is lower, by it is ultraviolet-can
The content of safranal is 0.32% in light-exposed spectrometer detection medicine materical crude slice.
The appearance photo of west safflower medicine materical crude slice made from the comparative example is shown in Fig. 2.
Comparative example 2
Using the dry west safflower of commercial microwave furnace, flower thickness 0.4cm, temperature 60 C are spread, interval is stirred once for 3 minutes, when
Between 20 minutes.
The flower shape curling of product made from this example.Dry west safflower is packed into plastic film bag, every bag of 50mg.
Finished product is set and is stored at shady and cool drying.It is separately sampled in 0,12,24 month, by 2015 editions Chinese Pharmacopoeias (one) west safflower
Regulation detection under, as a result crocin I and crocin II total amount are respectively 22%, 16%, 12%.
West safflower medicine materical crude slice obtained only has very light special fragranced, shows that safranal content is lower, by it is ultraviolet-can
The content of safranal is 0.3% in light-exposed spectrometer detection medicine materical crude slice.
The appearance photo of west safflower medicine materical crude slice made from the comparative example is shown in Fig. 2.
By the comparison of Fig. 1, Fig. 2 it is found that west safflower medicine materical crude slice flower-shape appearance looks elegant produced by the present invention, does not crimp；And
Comparative example 1~2 can be crimped using the west safflower medicine materical crude slice obtained after microwave drying.
Comparative example 3
Technique is evaporated using water proof west safflower is dried: west safflower laying metal (stainless steel) container is interior,
Paving flower directly uses heating water bath canister with a thickness of 0.5cm, and bath temperature is 90 DEG C, is spaced 5 minutes and stirs in heating process
Once, heating time 15 minutes.
The flower shape curling of product made from this example.Dry west safflower is packed into plastic film bag, every bag of 50mg.
Finished product is set and is stored at shady and cool drying.It is separately sampled in 0,12,24 month, by 2015 editions Chinese Pharmacopoeias (one) west safflower
Regulation detection under, as a result crocin I and crocin II total amount are respectively 21%, 19%, 18%.
West safflower medicine materical crude slice obtained only has very light special fragranced, shows that safranal content is lower, by it is ultraviolet-can
The content of safranal is 0.1% in light-exposed spectrometer detection medicine materical crude slice.
Claims (12)
1. a kind of preparation method of west safflower medicine materical crude slice comprising following step:
(1) dry: west safflower raw material being laid in canister, is carried out by the vapor heating metal container that water-bath generates
It is dry, and be spaced and stir, obtain semi-finished product 1；The temperature of the water-bath is 70~80 DEG C；
(2) it humidifies: semi-finished product 1 described in step (1) is laid in the porose container in bottom, the vapor that water-bath generates penetrates
Hole humidifies semi-finished product 1 described in step (1), to obtain semi-finished product 2；The temperature of the water-bath is 85~88 DEG C；
(3) redrying: semi-finished product 2 described in step (2) are laid in canister again, the vapor generated by water-bath
Heating metal container is dried, and is spaced and stirs；The temperature of the water-bath is 70~80 DEG C.
2. preparation method as described in claim 1, which is characterized in that in step (1), the canister is stainless steel appearance
Device；The tiling with a thickness of 0.3~0.8cm.
3. preparation method as claimed in claim 2, which is characterized in that in step (1), the tiling with a thickness of 0.3~
0.5cm。
4. preparation method as described in claim 1, which is characterized in that in step (1), the temperature of the water-bath is 70 DEG C,
75 DEG C, 79 DEG C or 80 DEG C.
5. preparation method as described in claim 1, which is characterized in that in step (1), the time of the drying is 10~20
Minute.
6. preparation method as described in claim 1, which is characterized in that in step (1), time interval that the interval is stirred
It is 3~5 minutes.
7. preparation method as described in claim 1, which is characterized in that in step (2), the mesh number in the hole is 4~18 mesh.
8. preparation method as described in claim 1, which is characterized in that in step (2), the time of the humidification is 3~5 points
Clock.
9. preparation method as described in claim 1, which is characterized in that in step (3), the canister is stainless steel appearance
Device；The tiling with a thickness of 0.3~0.8cm.
10. preparation method as claimed in claim 9, which is characterized in that in step (1), the tiling with a thickness of 0.3~
0.5cm。
11. preparation method as described in claim 1, which is characterized in that in step (3), the temperature of the water-bath is 70 DEG C,
75 DEG C, 79 DEG C or 80 DEG C.
12. preparation method as described in claim 1, which is characterized in that in step (3), time of the drying is 10~
20 minutes；
In step (3), the time interval that the interval is stirred is 3~5 minutes.
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| CN110522826A (en) * | 2019-08-28 | 2019-12-03 | 广东元德中药饮片有限公司 | A kind of west safflower prepared slices of Chinese crude drugs and preparation method thereof |
| CN114431385A (en) * | 2022-02-18 | 2022-05-06 | 杭州康馨宏生物技术有限公司 | Saffron-containing solid beverage, preparation method and application |
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| CN101946834A (en) * | 2010-08-31 | 2011-01-19 | 十堰梅子贡茶业集团 | Method for producing organic oolong tea |
| CN102100278A (en) * | 2010-12-29 | 2011-06-22 | 贵州三仁堂药业有限公司 | Method for processing eucommia bark leaves |
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