CN105902505A - Mulberry leaf and silkworm pupa chewable tablets and preparation method thereof - Google Patents
Mulberry leaf and silkworm pupa chewable tablets and preparation method thereof Download PDFInfo
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- CN105902505A CN105902505A CN201610366338.8A CN201610366338A CN105902505A CN 105902505 A CN105902505 A CN 105902505A CN 201610366338 A CN201610366338 A CN 201610366338A CN 105902505 A CN105902505 A CN 105902505A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
Abstract
The invention discloses mulberry leaf and silkworm pupa chewable tablets prepared from the following raw materials in parts by weight: 30-40 parts of mulberry leaves, 15-20 parts of degreased de-fishy silkworm pupa powder, 1-3 parts of mangiferin, 10-15 parts of sucrose, 5-10 parts of maltodextrin, 5-8 parts of magnesium stearate and 10-15 parts of starch. The high-nutrition mulberry leaf and silkworm pupa chewable tablets are produced via wet granulation and tabletting by using the mulberry leaves and the silkworm pupa as main raw materials, using the mangiferin as an auxiliary material and using the sucrose, starch, maltodextrin and magnesium stearate as aids. The chewable tablets have the effects of protecting liver and benefiting gallbladder, clearing lung-heat and moistening dryness, and removing liver-fire for improving eyesight, and can supplement eight amino acids necessary for human bodies in time. The chewable tablets realize sufficient utilization and multiplex development of advantageous resources in Guangxi, and provide a good way for increasing the incomes of silkworm raisers.
Description
Technical field
The invention belongs to food processing field, be specifically related to a kind of Folium Mori Pupa bombycis chewable tablet and preparation method thereof.
Background technology
Folium Mori, Chinese medicine name, is the dried leaves of moraceae plants Mulberry, is the conventional food of silkworm, [Classification system]Morus alba；
[another name] Epipremnum aureum (Linde et Andre) (Bunting.), family Mulberry, Jing Sang, Fructus Mori tree, yellow wood leaf, Mulberry jujube tree, intact leaf in or width egg shape, be about 15 centimetres, wide about
10 centimetres, petiole is about 4 centimetres, and blade base is heart-shaped, the micro-point in top, and there are sawtooth, vein Mi Shengbai pubescence in edge.Lao Ye is relatively
Thick yellow green.Tender leaf is relatively thin, dirty-green.Matter is crisp easily, holds pricking the hand.[nature and flavor] bitter in the mouth, sweet, cold in nature.Someone claims Folium Mori to be plant
King, have the good reputation of " Radix Ginseng is vulcanized, and Folium Mori are mended clearly ".Rich in 17 kinds of aminoacid of human body, crude protein, crude fat, it is that country defends
Life portion confirm " integration of edible and medicinal herbs " plant, by international food health organization list in " 21st century of the mankind ten big health food it
One ", the green new food source of the mankind is become.[effect] dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing liver-YANG, effect of liver heat removing and eyesight improving.[main
Control] anemopyretic cold, lung-heat type cough, dizziness headache, the disease that conjunctival congestion is dim-sighted can be treated.It addition, Quercetin contained in Folium Mori, phenol
The composition such as compounds, vitamin C can prevent oxidative damage by suppression or removing free radical, and therefore Folium Mori have defying age
Effect.The effect that Folium Mori have the tonification of similar Radix Ginseng and defying age, stablize nervous function, can alleviate physiological change and cause
Excited, improve the activity of internal superoxide dismutase, stop the generation of internal harmful substance, be reduced or eliminated
Produce and stagnate in internal lipofuscin.Folium Mori can improve mice to the tolerance of high temperature stimulation and to be prevented due to stress stimulation
The adrenal cortex distributed function caused is low, and when adrenal function is low, Folium Mori can be allowed to recover normal.Folium Mori can prolong
The swimming of long mice and transfer rod time, there is enhancing body Endurence, the life-span of fruit bat can be extended, can effectively remove biological oxygen
Change the superoxide anion produced, there is the effect of slow down aging.Effect that Folium Mori are also subsided a swelling, purified the blood.Folium Mori why can
Detumescence, being because Folium Mori has the effect of diuretic.Diuretic effect is different from diuresis, not only can promote to urinate, it is also possible to make
The excessive moisture amassed in cell is drained.So Folium Mori can improve so-called edema phenomenon.Purify the blood superfluous in blood
Neutral fat and cholesterol clear.Neutral fat or cholesterol increase in blood are exactly too much hyperlipidemia.So fat people is many
For hyperlipidemia patient.Folium Mori have the effect improving this hyperlipidemia.
Pupa bombycis, for the pupal cell stayed after the black silk of Bombyx bombycis of Bombycidae insecticide silkworm.Pupa bombycis [Latin] Bombyx mori
L.；[nature and flavor with return through] are sweet, pungent, salty, tepor.Return spleen, stomach, liver, kidney channel.[function with cure mainly] promoting the production of body fluid to quench thirst, helps digestion and regulates the flow of vital energy.
For quenching one's thirst, become thin, infantile malnutrition.Chinese medicine is thought, this product nature and flavor are sweet, warm, salty, pungent, returns spleen, stomach, kidney channel.Warming YANG is had to mend
Kidney, expelling wind and removing dampness, the merit of spleen invigorating removing food stagnancy, it is adaptable to kidney yang virtual loss, impotence and seminal emission, rheumatic arthralgia, infantile malnutrition etc.." book on Chinese herbal medicine guiding principle
Mesh " say that it " is controlled infantile emaciation, longue, bring down a fever, except ascarid "." medical center bun will " says its " and taste, wind-damp dispelling, long yang-energy ".Medicine
Reason research shows, Pupa bombycis fatty 28% ~ 30%, protein 56% ~ 63%, and possibly together with mineral such as calcium, phosphorus, ferrum, abundant dimension is raw
The compositions such as element and hormone.Silkworm chrysalis protein is made up of 18 kinds of aminoacid, and wherein 8 kinds of amino acid contents of needed by human are the highest.Silkworm
The amino acid content of these the 8 kinds of needed by human in pupa is about 2 times of Carnis Sus domestica, 4 times of egg, 10 times of milk, and nutrition is equal
Weighing apparatus, ratio are suitable, are the insect proteins of a kind of high-quality.Contained protein is easily hydrolyzed, and similar to human body protein, people
Body absorbance is about 90%.Therefore, food Pupa bombycis both can supplement fat, protein and multivitamin, can increase again brain cell and live
Power, improves ability of thinking.Pupa bombycis contains abundant chitin, and it extracts name chitosan.Research shows, chitin, chitosan
There is the function such as raising immunity of organisms, strengthening liver.On the ground such as the U.S., Japan, as new food additive.Silkworm
Containing substantial amounts of arginine in pupa, its content exceedes chicken, fish, meat, egg.Arginine energy allaying tiredness, raising sexual function, be to manufacture
The important source material of mankind spermatozoon albumen, and to diseases such as chronic hepatitis, cardio-cerebrovascular disorder, leukopenia and malnutrition, all
There is obvious curative effect.China cooperates with Sweden scientist, extracts a kind of broad immune material from Antheraea pernyi Geurin Meneville.This material is to cancer
Disease, arteriosclerosis, hepatitis, nephritis etc. are the most effective in cure.Pupa bombycis has suppression to staphylococcus aureus, escherichia coli and bacillus pyocyaneus
Effect, has preferable antiinflammatory and anti-infectious function.Its contained unsaturated fatty acid has abatement human body excess cholesterol
Effect.It is demonstrated that Pupa bombycis all has certain regulation effect to body sugar, lipid metabolism.
Now, in Guangxi, Sang Yangcan is planted in a lot of places on a large scale, and Bombyxmori Linnaeus yield is positioned at domestic first or the in recent years
Two, after annual sericulture, there are many Folium Mori to go out of use, cause no small waste.And the Bombyx bombycis of Bombycidae insecticide silkworm
Pupal cell-the Pupa bombycis stayed after black silk can produce the material with pharmacological activity, can be effectively improved leucocyte level in human body, from
And improve immunity, slow down aging.But there is presently no people and for main material production one, both there is guarantor with Folium Mori and Pupa bombycis
Effect of liver function of gallbladder promoting, clearing away lung-heat and moistening for dryness and liver heat removing and eyesight improving, can supplement again the amino acid whose chewable tablet of needed by human in time.This chewable tablet
Invention make the plant in Guangxi can be fully used and development in pluralism, this also will be the numerous silkworm raisers good door that increases income
Road.
Summary of the invention
For the technological deficiency of above-mentioned existence, it is an object of the invention to provide a kind of Folium Mori Pupa bombycis chewable tablet, i.e. with Folium Mori
It is effect that main material production one had both had hepatic cholagogic, clearing away lung-heat and moistening for dryness and liver heat removing and eyesight improving with Pupa bombycis, can supplement in time again
The amino acid whose chewable tablet of needed by human.The invention of this chewable tablet makes the plant in Guangxi to be fully used and diversification is sent out
Exhibition, this also will be the numerous silkworm raisers good social connections that increase income.
Folium Mori Pupa bombycis chewable tablet, including the raw material of following parts by weight:
Folium Mori 30-40 part；
Raw meat dried silkworm chrysalis meal 15-20 part is gone in defat；
Chimonin 1-3 part；
Sucrose 10-15 part；
Maltodextrin 5-10 part；
Magnesium stearate 5-8 part；
Starch 10-15 part.
Described Folium Mori are that the step completed is through the Folium Mori processed that complete: (1), purchase is green, do not have pest and disease damage
Folium Mori；(2) complete at a temperature of, completing in 150-160 DEG C 5 minutes；(3), then in 75-80 DEG C of steaming and decocting 10 minutes；(4), in 60-
65 DEG C of cold drying, are kneaded to moisture below 5%.
Described defat goes the preparation method of raw meat dried silkworm chrysalis meal to be: (1), fresh silkworm chrysalis sieved, and removes powder, silt, beats
Slurry, obtains Pupa bombycis slurry；Press Pupa bombycis slurry the most again；Being that 1:5 adds water with the weight ratio of water, under 50-58 DEG C of constant temperature, steaming and decocting 30 minutes, remove
Defoam and oil slick, then wash by rubbing with the hands in flowing water, until without oil slick and foam impurity, obtaining defat silkworm in Pupa bombycis slurry loading cloth bag
Pupa is starched；(2), to add defat Pupa bombycis 2-3 times of volume mass concentration of slurry be the acetum of 75%, then steams in 60-70 DEG C of constant temperature
After evaporating 20-30 minute, remove the polyamine compounds in defat Pupa bombycis slurry；Add the spice of defat Pupa bombycis slurry weight 0.5 times
Powder reacts 30-35 minute in 60-70 DEG C, removes the raw meats such as the aldehyde in defat Pupa bombycis slurry, ketone and hides composition；(3), last in 60-65 DEG C
Cold drying to moisture, obtains defat and removes raw meat dried silkworm chrysalis meal below 5%.
The described mixture that spice powder is Cortex cinnamomi japonici powder and star aniseed powder, the part by weight of Cortex cinnamomi japonici powder and star aniseed powder is 1:1.
The extracting method of described chimonin is: mangrove bark is ground into coarse powder, weighs 50g coarse powder, according to solid-liquid ratio is
1:10, add mass concentration be the ethanol solution of 70% as Extraction solvent, microwave power 600 W, extraction time 15min, take out
Filter, and with the ethanol solution washing residue that mass concentration is 70%, reclaim ethanol after merging, be concentrated into solution 5-10mL, move into and divide
Liquid funnel, by little water washing and recycling bottle (the most repeatedly), extracts with chloroform 20mL/ time (adding 5 10% sodium chloride solutions)
3 times, collecting water layer, lyophilization, obtain chimonin, chimonin extracted amount is 4.622 mg/g.
The preparation method of Folium Mori Pupa bombycis chewable tablet is:
1) chimonin of 1-3 part weight portion, the sucrose of 10-15 weight portion, the maltodextrin of 5-10 weight portion, 15-20 weight, are taken
The defat of part goes the magnesium stearate of raw meat dried silkworm chrysalis meal and 5-8 weight portion to pulverize respectively, crosses 120 mesh sieves respectively standby；
2), the starch of the Folium Mori and 10-15 weight portion that take 30-40 weight portion is placed in mixer mixing 10-30 minute, then by upper
State mixed powder and be placed in super micron mill pulverizing, be ground into the superfine powder of 5-8 μm, after above-mentioned superfine powder adds step 1) pulverizing
Maltodextrin, and be sufficiently mixed, obtain mixed powder A；
3), raw meat dried silkworm chrysalis meal and step 2 are gone in the chimonin after above-mentioned pulverizing, sucrose, defat) in mixed powder A mix and stir
Mix uniformly, obtain mixed powder B；
4), the mixed powder B in step 3) being slowly added to the ethanol water that volumetric concentration is 70%, ethanol addition is with just
Good energy moistening material, crosses 20 mesh sieves, obtains wet grain；
5), by the wet grain of step 4) it is placed in the drying baker that temperature is 45 DEG C to be dried, is dried to its water content below 5%,
Crossing 60 mesh sieves, the magnesium stearate after addition step 1) pulverizing, as lubricant, mix homogeneously, is placed in tabletting in tablet machine；
6), compacting tablet use microwave sterilizating, the temperature of microwave is in the range of 90 DEG C, and sterilization time is 3-8 minute.
Described powder of Folium Mori be Folium Mori through completing, steaming and decocting, knead and pulverize after the powder that obtains.Folium Mori [Classification system]Morus alba, [another name] Epipremnum aureum (Linde et Andre) (Bunting.), family Mulberry, Jing Sang, Fructus Mori tree, yellow wood leaf, Mulberry jujube tree, [nature and flavor] bitter in the mouth, sweet, cold in nature.[merit
Effect] dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing liver-YANG, effect of liver heat removing and eyesight improving.[curing mainly] can treat anemopyretic cold, lung-heat type cough, head
Dizzy headache, the disease that conjunctival congestion is dim-sighted.
Described defat go raw meat dried silkworm chrysalis meal be Pupa bombycis through defat, go raw meat, deodorization after obtain.Containing a large amount of in Pupa bombycis raw material
The nutrient substance such as protein, aminoacid and lecithin, due to environment and the bacterial action of self, multiple fishy smell thing can be produced
Matter, such as compounds such as polyamine compounds (dimethylamine, n-butylamine) and aldehyde, ketone and heterocycle compounds.If not by Pupa bombycis
The strongest bad smell is removed, and has a strong impact on the mouthfeel of chewable tablet, and then affects the value of Pupa bombycis.Therefore, the present invention
Defat go raw meat dried silkworm chrysalis meal preparation during, first fresh silkworm chrysalis is removed powder, silt, then adds water in 50-58 DEG C
30 minutes scumming of steaming and decocting and oil slick, in this heating digestion process, the fishy smell material such as first sulfur that Pupa bombycis mid-boiling point is relatively low
Alcohol, ethyl mercaptan and carbamide and low molecular acid etc. also are able to remove, and obtain defat Pupa bombycis slurry；And then add in proper amount of acetic acid
With the polyamine compounds (mostly being alkali compounds, pH value is more than 7.25) in Pupa bombycis so that it is generate acetic acid salt, so that it may make raw meat
Stink greatly weakens；Add appropriate Cortex cinnamomi japonici (Ramulus Cinnamomi) and anise, rich in volatile oil and organic acid in Cortex cinnamomi japonici (Ramulus Cinnamomi), rich in anise alcohol in anise
And methoxybenzene, it is anti-that above-mentioned substance all can make the raw meats such as the aldehyde in Pupa bombycis, ketone hide composition generation oxidation reaction, aldolisation or esterification
Should, make abnormal flavour weaken and can flavouring, use in the denseer Pupa bombycis raw material of sheep offensive smell especially, it goes raw meat deodorizing effect to become apparent from.
After removing bad smell, in 60-65 DEG C of cold drying to moisture below 5%, finally give defat and remove raw meat dried silkworm chrysalis meal.
Pupa bombycis, for the pupal cell stayed after the black silk of Bombyx bombycis of Bombycidae insecticide silkworm.Pupa bombycis [Latin]Bombyx mori L.；[nature and flavor with return through] are sweet, pungent, salty, tepor.Return spleen, stomach, liver, kidney channel.[function with cure mainly] promoting the production of body fluid to quench thirst, helps digestion and regulates the flow of vital energy.
For quenching one's thirst, become thin, infantile malnutrition.Pharmacological research shows, Pupa bombycis fatty 28% ~ 30%, protein 56% ~ 63%, possibly together with calcium,
The mineral such as phosphorus, ferrum, the composition such as abundant vitamin and hormone.Silkworm chrysalis protein is made up of 18 kinds of aminoacid, and wherein human body must
The 8 kinds of amino acid contents needed are the highest.The amino acid content of these the 8 kinds of needed by human in Pupa bombycis is about 2 times of Carnis Sus domestica, egg
4 times, 10 times of milk, and balanced in nutrition, ratio is suitable, is the insect protein of a kind of high-quality.Contained protein is easily by water
Solve, and similar to human body protein, human absorptivity is about 90%.
Chimonin, English name:mangiferin；Another name: mangiferin, mangiferin；Chemical formula: C19H18O11；Molecule
Amount: 422.33；CAS accession number: 4773-96-0；Fusing point 267～272 DEG C；Water solublity: the most molten；Outward appearance: light lark needle-like
Crystallization.Chimonin is present in the fruit of Anacardiaceae plant Fructus Mangifera Indicae (Mangifera indica L.), leaf, bark, liliaceous plant
The rhizome of the Rhizoma Anemarrhenae (Anemarrhena asphodeloides Bge.), aerial parts, irides Rhizoma Belamcandae [Belamcanda
Chinensis(L.) DC.] flower, in the plant such as leaf.Chimonin, being used for treating chronic bronchitis has good therapeutic effect, is to hide mattress
The principle active component of old treatment hepatitis, is the active component of antiviral in Asphodeloides Bge Rhizome.Chimonin, has dispersing lung-QI and dissipating phlegm, only
Effect that cloperastine is breathed heavily.It is usually used in cough, asthma, the treatment of excessive phlegm clinically.Incubate in experiment in the outer temperature of rats'liver lysosome and send out
Existing, chimonin has the effect of stable lysosome membrane, and lysosomal acid phosphatase vigor is had direct repression, therefore Fructus Mangifera Indicae
Glycosides has the effect of hepatic cholagogic.
Anise, [Classification system]Illicium verum Hook.f.；[another name] Fructus Anisi Stellati, Fructus Anisi Stellati, mark angle, be dried
Mature fruit contains containing aromatic oil, fatty oil, protein, resin etc., and extract is Oleum Anisi Stellati, wherein containing Oleum Anisi Stellati in seed
The star anise oil content of 1.7%-2.7%, dry fruit and cured leaf is respectively 12%-13%, 1.6%-1.8%.Oleum Anisi Stellati be mainly composed of fennel
Fragrant ether (Anethole), anise alcohol and safrole (Safrole) etc..
Cortex cinnamomi japonici (Ramulus Cinnamomi), [Classification system]Cinnamomum tamala (Bauch.-Ham.) Nees et Eberm[another name] bavin
Osmanthus, Cortex Cinnamomi Bejolghotae, soil osmanthus.The bark of Cinnamomum japonica contains volatile oil about 1%, its volatilize Water in oil celery alkene, eugenol, methyl Flos Caryophylli
Oil phenol, leaf contains volatile oil about 1%, and containing safrole about 60% in its volatile oil, eugenol about 3%, possibly together with 1,8-presses foline etc..
The bark of cinnamomum chingii Metcalf contains volatile oil about 1%, and containing tannin 12.8% in its volatile oil, leaf contains volatile oil about 1%, the fatty oil of seed
40%.Possibly together with organic acid in Cortex cinnamomi japonici (Ramulus Cinnamomi).
In the present invention, the function of each composition is:
Folium Mori bitter in the mouth, sweet, cold in nature, there is effect of dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing liver-YANG, liver heat removing and eyesight improving；Contained by Folium Mori
Quercetin, phenolic compound, the composition such as vitamin C by suppression or remove free radical and prevent oxidative damage, and can assist
Liver detoxification function；The effect that Folium Mori have the tonification of similar Radix Ginseng and defying age, stablize nervous function, can alleviate physiology
It is excited that change causes, and improves the activity of internal superoxide dismutase, stops the generation of internal harmful substance, reduce or
Eliminate and produced and stagnated in internal lipofuscin；
Pupa bombycis, [nature and flavor with return through] are sweet, pungent, salty, tepor.Return spleen, stomach, liver, kidney channel.[function with cure mainly] promoting the production of body fluid to quench thirst, disappears
Food is regulated the flow of vital energy.For quenching one's thirst, become thin, infantile malnutrition.Pharmacological research shows, Pupa bombycis fatty 28% ~ 30%, protein 56% ~ 63%, also
Containing compositions such as the mineral such as calcium, phosphorus, ferrum, abundant vitamin and hormones.Silkworm chrysalis protein is made up of, wherein 18 kinds of aminoacid
8 kinds of amino acid contents of needed by human are the highest.Protein contained by Pupa bombycis is easily hydrolyzed, and similar to human body protein, human body
Absorbance is high；
Chimonin, is the principle active component of ZANGYINCHEN treatment hepatitis.Chimonin, has dispersing lung-QI and dissipating phlegm, effect of relieving cough and asthma.
It is usually used in cough, asthma, the treatment of excessive phlegm clinically.Chimonin also has the effect of hepatic cholagogic.
Compared with prior art, the present invention has a following beneficial effect:
1, the marked improvement of the present invention is, on the basis of keeping Folium Mori and chimonin to have hepatoprotective function, utilizes Pupa bombycis
(Pupa bombycis fatty 28% ~ 30%, protein 56% ~ 63%, also contain to increase the important nutritional labeling-protein required for people every day
There are the compositions such as the mineral such as calcium, phosphorus, ferrum, abundant vitamin and hormone.Silkworm chrysalis protein is made up of 18 kinds of aminoacid, Qi Zhongren
The required 8 kinds of amino acid contents of body are the highest), strengthen its specificity function, (Pupa bombycis removes raw meat deodorization, Folium Mori warp through defat to raciness
Complete) and active nutrient component height.The present invention is with Folium Mori and Pupa bombycis as primary raw material, with chimonin as adjuvant, with sucrose, wheat
Bud dextrin and magnesium stearate are auxiliary agent, and after wet granulation, the Folium Mori Pupa bombycis chewable tablet of high nutritional quality produced by tabletting, both
There is effect of hepatic cholagogic, clearing away lung-heat and moistening for dryness and liver heat removing and eyesight improving, can supplement again that 8 kinds of needed by human are amino acid whose to be chewed in time
Sheet.The invention of this chewable tablet makes the plant in Guangxi to be fully used and development in pluralism, and this also will be that numerous silkworm raisers increase
The good social connections of income.
2, the present invention is during raw meat dried silkworm chrysalis meal is removed in defat, and first fresh silkworm chrysalis removes powder, silt, then add water in
30 minutes scumming of 50-58 DEG C of steaming and decocting and oil slick, in this heating digestion process, the fishy smell material that Pupa bombycis mid-boiling point is relatively low
As methanthiol, ethyl mercaptan and carbamide and low molecular acid etc. also are able to remove, obtain defat Pupa bombycis slurry；And then add appropriate
Polyamine compounds (mostly being alkali compounds, pH value is more than 7.25) in acetic acid and in Pupa bombycis so that it is generate acetic acid salt, just
Bad smell can be made greatly to weaken；Add appropriate Cortex cinnamomi japonici (Ramulus Cinnamomi) and anise, rich in volatile oil and organic acid in Cortex cinnamomi japonici (Ramulus Cinnamomi), in anise rich in
Anise alcohol and methoxybenzene, above-mentioned substance all can make the raw meats such as the aldehyde in Pupa bombycis, ketone hide composition generation oxidation reaction, aldolisation or ester
Change reaction, make abnormal flavour weaken and can flavouring, use in the denseer Pupa bombycis raw material of sheep offensive smell especially, it goes raw meat deodorizing effect brighter
Aobvious.After removing bad smell, in 60-65 DEG C of cold drying to moisture below 5%, obtain defat and remove raw meat dried silkworm chrysalis meal.Pass through
Defat after process goes raw meat dried silkworm chrysalis meal protein content to be improved to 60% by 50%, and color is shallow white, free from extraneous odour, tastes without pained
Taste.
3, the Folium Mori whole preparation process of Pupa bombycis chewable tablet of the present invention uses food grade materials completely, product will not be made
Becoming secondary pollution, the Folium Mori Pupa bombycis chewable tablet prepared can be applied completely in field of health care food.
4, the Folium Mori Pupa bombycis chewable tablet primary treatment of the present invention because of damp and hot exopathogen or be addicted to drink, surfeit delicious food and the liver and gall that cause
Damp-heat syndrome, cardinal symptom is vexed for coercing swollen gastral cavity, feels sick and detests oil, indigestion and loss of appetite, the jaundice of body mesh and bright and lustrous, yellowish urine, mouth glues bitter taste, stool
Viscous dirty smelly or first knot after half congealed, or drink and few, the limbs spare time weight, fatigue and weakness, yellowish fur, the patient of pulse condition stringy and rapid pulse, every day
Early, evening, the most once after taking medicine one week, total effective rate was 92.59%, and after taking two weeks, total effective rate is 96.87%.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, all
Belong to the scope of protection of the invention.
Embodiment 1
Folium Mori Pupa bombycis chewable tablet, including the raw material of following parts by weight:
30 parts of Folium Mori；
Raw meat dried silkworm chrysalis meal 15 parts is removed in defat；
Chimonin 1 part；
Sucrose 10 parts；
Maltodextrin 5 parts；
Magnesium stearate 5 parts；
Starch 10 parts.
Described Folium Mori are that the step completed is through the Folium Mori processed that complete: (1), purchase is green, do not have pest and disease damage
Folium Mori；(2) complete at a temperature of, completing in 150 DEG C 5 minutes；(3), then in 75 DEG C of steaming and decoctings 10 minutes；(4), do in 60 DEG C of low temperature
Dry to moisture below 5%, knead.
Described defat goes the preparation method of raw meat dried silkworm chrysalis meal to be: (1), fresh silkworm chrysalis sieved, and removes powder, silt, beats
Slurry, obtains Pupa bombycis slurry；Starch by Pupa bombycis the most again and the weight ratio of water is that 1:5 adds water, steaming and decocting 30 minutes under 50 DEG C of constant temperature, remove bubble
Foam and oil slick, then wash by rubbing with the hands in flowing water, until without oil slick and foam impurity, obtaining defat Pupa bombycis in Pupa bombycis slurry loading cloth bag
Slurry；(2), add defat Pupa bombycis and starch the acetum that mass concentration is 75% of 2 times of volumes, then in 60 DEG C of constant temperature distillations 30 points
Zhong Hou, removes the polyamine compounds in defat Pupa bombycis slurry；The spice powder adding defat Pupa bombycis slurry weight 0.5 times is anti-in 60 DEG C
Answer 35 minutes, remove the raw meats such as the aldehyde in defat Pupa bombycis slurry, ketone and hide composition；(3), in 60 DEG C of cold drying to moisture 5%
Hereinafter, obtain defat and remove raw meat dried silkworm chrysalis meal.
The described mixture that spice powder is Cortex cinnamomi japonici powder and star aniseed powder, the part by weight of Cortex cinnamomi japonici powder and star aniseed powder is 1:1.
The extracting method of described chimonin is: mangrove bark is ground into coarse powder, weighs 50g coarse powder, according to solid-liquid ratio is
1:10, add mass concentration be the ethanol solution of 70% as Extraction solvent, microwave power 600 W, extraction time 15min, take out
Filter, and with the ethanol solution washing residue that mass concentration is 70%, reclaim ethanol after merging, be concentrated into solution 5-10mL, move into and divide
Liquid funnel, with little water washing and recycling bottle, with chloroform 20mL/ time, wherein adds 5 10% sodium chloride solutions, extracts 3 in chloroform
Secondary, collect water layer, lyophilization, obtain chimonin.
The preparation method of Folium Mori Pupa bombycis chewable tablet is:
1), take the chimonin of 1 weight portion, raw meat is removed in the sucrose of 10 weight portions, the maltodextrin of 5 weight portions, the defat of 15 weight portions
The magnesium stearate of dried silkworm chrysalis meal and 5 weight portions is pulverized respectively, crosses 120 mesh sieves respectively standby；
2), the starch of the Folium Mori and 10 weight portions that take 30 weight portions is placed in mixer mixing 10 minutes, then by above-mentioned mixed powder
It is placed in super micron mill to pulverize, is ground into the superfine powder of 5-8 μm, add the Fructus Hordei Germinatus after step 1) is pulverized to above-mentioned superfine powder and stick with paste
Essence, and be sufficiently mixed, obtain mixed powder A；
3), raw meat dried silkworm chrysalis meal and step 2 are gone in the chimonin after above-mentioned pulverizing, sucrose, defat) in mixed powder A mix and stir
Mix uniformly, obtain mixed powder B；
4), the mixed powder B in step 3) being slowly added to the ethanol water that volumetric concentration is 70%, ethanol addition is with just
Good energy moistening material, crosses 20 mesh sieves, obtains wet grain；
5), by the wet grain of step 4) it is placed in the drying baker that temperature is 45 DEG C to be dried, is dried to its water content below 5%,
Crossing 60 mesh sieves, the magnesium stearate after addition step 1) pulverizing, as lubricant, mix homogeneously, is placed in tabletting in tablet machine；
6), compacting tablet use microwave sterilizating, the temperature of microwave is in the range of 90 DEG C, and sterilization time is 3-8 minute.
Embodiment 2
Folium Mori Pupa bombycis chewable tablet, including the raw material of following parts by weight:
32 parts of Folium Mori；
Raw meat dried silkworm chrysalis meal 16 parts is removed in defat；
Chimonin 1.5 parts；
Sucrose 11 parts；
Maltodextrin 6 parts；
Magnesium stearate 6 parts；
Starch 11 parts.
Described Folium Mori are that the step completed is through the Folium Mori processed that complete: (1), purchase is green, do not have pest and disease damage
Folium Mori；(2) complete at a temperature of, completing in 152 DEG C 5 minutes；(3), then in 76 DEG C of steaming and decoctings 10 minutes；(4), do in 61 DEG C of low temperature
Dry to moisture below 5%, knead.
Described defat goes the preparation method of raw meat dried silkworm chrysalis meal to be: (1), fresh silkworm chrysalis sieved, and removes powder, silt, beats
Slurry, obtains Pupa bombycis slurry；Press Pupa bombycis slurry the most again；It is that 1:5 adds water with the weight ratio of water, steaming and decocting 30 minutes under 52 DEG C of constant temperature, remove
Foam and oil slick, then wash by rubbing with the hands in flowing water, until without oil slick and foam impurity, obtaining defat Pupa bombycis in Pupa bombycis slurry loading cloth bag
Slurry；(2), to add defat Pupa bombycis 2 times of volume mass concentration of slurry be the acetum of 75%, then distills 28 minutes in 62 DEG C of constant temperature
After, remove the polyamine compounds in defat Pupa bombycis slurry；Add the spice powder of defat Pupa bombycis slurry weight 0.5 times in 62 DEG C of reactions
34 minutes, remove the raw meats such as the aldehyde in defat Pupa bombycis slurry, ketone and hide composition；(3), last in 61 DEG C of cold drying to moisture 5%
Hereinafter, obtain defat and remove raw meat dried silkworm chrysalis meal.
The described mixture that spice powder is Cortex cinnamomi japonici powder and star aniseed powder, the part by weight of Cortex cinnamomi japonici powder and star aniseed powder is 1:1.
The extracting method of chimonin is with embodiment 1.
The preparation method of Folium Mori Pupa bombycis chewable tablet is:
1), take the chimonin of 1.5 weight portions, the sucrose of 11 weight portions, the maltodextrin of 6 weight portions, the defat of 16 weight portions are gone
The magnesium stearate of raw meat dried silkworm chrysalis meal and 6 weight portions is pulverized respectively, crosses 120 mesh sieves respectively standby；
2), the starch of the Folium Mori and 11 weight portions that take 32 weight portions is placed in mixer mixing 15 minutes, then by above-mentioned mixed powder
It is placed in super micron mill to pulverize, is ground into the superfine powder of 5-8 μm, add the Fructus Hordei Germinatus after step 1) is pulverized to above-mentioned superfine powder and stick with paste
Essence, and be sufficiently mixed, obtain mixed powder A；
3), raw meat dried silkworm chrysalis meal and step 2 are gone in the chimonin after above-mentioned pulverizing, sucrose, defat) in mixed powder A mix and stir
Mix uniformly, obtain mixed powder B；
4), the mixed powder B in step 3) being slowly added to the ethanol water that volumetric concentration is 70%, ethanol addition is with just
Good energy moistening material, crosses 20 mesh sieves, obtains wet grain；
5), by the wet grain of step 4) it is placed in the drying baker that temperature is 45 DEG C to be dried, is dried to its water content below 5%,
Crossing 60 mesh sieves, the magnesium stearate after addition step 1) pulverizing, as lubricant, mix homogeneously, is placed in tabletting in tablet machine；
6), compacting tablet use microwave sterilizating, the temperature of microwave is in the range of 90 DEG C, and sterilization time is 3-8 minute.
Embodiment 3
Folium Mori Pupa bombycis chewable tablet, including the raw material of following parts by weight:
34 parts of Folium Mori；
Raw meat dried silkworm chrysalis meal 17 parts is removed in defat；
Chimonin 1.5 parts；
Sucrose 12 parts；
Maltodextrin 7 parts；
Magnesium stearate 7 parts；
Starch 12 parts.
Described Folium Mori are that the step completed is through the Folium Mori processed that complete: (1), purchase is green, do not have pest and disease damage
Folium Mori；(2) complete at a temperature of, completing in 154 DEG C 5 minutes；(3), then in 77 DEG C of steaming and decoctings 10 minutes；(4), do in 62 DEG C of low temperature
Dry to moisture below 5%, knead.
Described defat goes the preparation method of raw meat dried silkworm chrysalis meal to be: (1), fresh silkworm chrysalis sieved, and removes powder, silt, beats
Slurry, obtains Pupa bombycis slurry；Press Pupa bombycis slurry the most again；It is that 1:5 adds water with the weight ratio of water, steaming and decocting 30 minutes under 54 DEG C of constant temperature, remove
Foam and oil slick, then wash by rubbing with the hands in flowing water, until without oil slick and foam impurity, obtaining defat Pupa bombycis in Pupa bombycis slurry loading cloth bag
Slurry；(2), to add defat Pupa bombycis 2 times of volume mass concentration of slurry be the acetum of 75%, then distills 26 minutes in 64 DEG C of constant temperature
After, remove the polyamine compounds in defat Pupa bombycis slurry；Add the spice powder of defat Pupa bombycis slurry weight 0.5 times in 64 DEG C of reactions
33 minutes, remove the raw meats such as the aldehyde in defat Pupa bombycis slurry, ketone and hide composition；(3), last in 62 DEG C of cold drying to moisture 5%
Hereinafter, obtain defat and remove raw meat dried silkworm chrysalis meal.
The described mixture that spice powder is Cortex cinnamomi japonici powder and star aniseed powder, the part by weight of Cortex cinnamomi japonici powder and star aniseed powder is 1:1.
The extracting method of chimonin is with embodiment 1.
The preparation method of Folium Mori Pupa bombycis chewable tablet is:
1), take the chimonin of 1.5 weight portions, the sucrose of 12 weight portions, the maltodextrin of 7 weight portions, the defat of 17 weight portions are gone
The magnesium stearate of raw meat dried silkworm chrysalis meal and 7 weight portions is pulverized respectively, crosses 120 mesh sieves respectively standby；
2), the starch of the Folium Mori and 12 weight portions that take 34 weight portions is placed in mixer mixing 20 minutes, then by above-mentioned mixed powder
It is placed in super micron mill to pulverize, is ground into the superfine powder of 5-8 μm, add the Fructus Hordei Germinatus after step 1) is pulverized to above-mentioned superfine powder and stick with paste
Essence, and be sufficiently mixed, obtain mixed powder A；
3), raw meat dried silkworm chrysalis meal and step 2 are gone in the chimonin after above-mentioned pulverizing, sucrose, defat) in mixed powder A mix and stir
Mix uniformly, obtain mixed powder B；
4), the mixed powder B in step 3) being slowly added to the ethanol water that volumetric concentration is 70%, ethanol addition is with just
Good energy moistening material, crosses 20 mesh sieves, obtains wet grain；
5), by the wet grain of step 4) it is placed in the drying baker that temperature is 45 DEG C to be dried, is dried to its water content below 5%,
Crossing 60 mesh sieves, the magnesium stearate after addition step 1) pulverizing, as lubricant, mix homogeneously, is placed in tabletting in tablet machine；
6), compacting tablet use microwave sterilizating, the temperature of microwave is in the range of 90 DEG C, and sterilization time is 3-8 minute.
Embodiment 4
Folium Mori Pupa bombycis chewable tablet, including the raw material of following parts by weight:
36 parts of Folium Mori；
Raw meat dried silkworm chrysalis meal 18 parts is removed in defat；
Chimonin 2 parts；
Sucrose 13 parts；
Maltodextrin 8 parts；
Magnesium stearate 7 parts；
Starch 13 parts.
Described Folium Mori are that the step completed is through the Folium Mori processed that complete: (1), purchase is green, do not have pest and disease damage
Folium Mori；(2) complete at a temperature of, completing in 156 DEG C 5 minutes；(3), then in 78 DEG C of steaming and decoctings 10 minutes；(4), do in 63 DEG C of low temperature
Dry to moisture below 5%, knead.
Described defat goes the preparation method of raw meat dried silkworm chrysalis meal to be: (1), fresh silkworm chrysalis sieved, and removes powder, silt, beats
Slurry, obtains Pupa bombycis slurry；Press Pupa bombycis slurry the most again；It is that 1:5 adds water with the weight ratio of water, steaming and decocting 30 minutes under 56 DEG C of constant temperature, remove
Foam and oil slick, then wash by rubbing with the hands in flowing water, until without oil slick and foam impurity, obtaining defat Pupa bombycis in Pupa bombycis slurry loading cloth bag
Slurry；(2), adding defat Pupa bombycis, to starch 2 .5 times of volume mass concentration be the acetum of 75%, then distills 24 points in 66 DEG C of constant temperature
Zhong Hou, removes the polyamine compounds in defat Pupa bombycis slurry；The spice powder adding defat Pupa bombycis slurry weight 0.5 times is anti-in 66 DEG C
Answer 32 minutes, remove the raw meats such as the aldehyde in defat Pupa bombycis slurry, ketone and hide composition；(3), finally exist to moisture in 63 DEG C of cold drying
Less than 5%, obtain defat and remove raw meat dried silkworm chrysalis meal.
The described mixture that spice powder is Cortex cinnamomi japonici powder and star aniseed powder, the part by weight of Cortex cinnamomi japonici powder and star aniseed powder is 1:1.
The extracting method of chimonin is with embodiment 1.
The preparation method of Folium Mori Pupa bombycis chewable tablet is:
1), take the chimonin of 2 weight portions, raw meat is removed in the sucrose of 13 weight portions, the maltodextrin of 8 weight portions, the defat of 18 weight portions
The magnesium stearate of dried silkworm chrysalis meal and 7 weight portions is pulverized respectively, crosses 120 mesh sieves respectively standby；
2), the starch of the Folium Mori and 13 weight portions that take 36 weight portions is placed in mixer mixing 25 minutes, then by above-mentioned mixed powder
It is placed in super micron mill to pulverize, is ground into the superfine powder of 5-8 μm, add the Fructus Hordei Germinatus after step 1) is pulverized to above-mentioned superfine powder and stick with paste
Essence, and be sufficiently mixed, obtain mixed powder A；
3), raw meat dried silkworm chrysalis meal and step 2 are gone in the chimonin after above-mentioned pulverizing, sucrose, defat) in mixed powder A mix and stir
Mix uniformly, obtain mixed powder B；
4), the mixed powder B in step 3) being slowly added to the ethanol water that volumetric concentration is 70%, ethanol addition is with just
Good energy moistening material, crosses 20 mesh sieves, obtains wet grain；
5), by the wet grain of step 4) it is placed in the drying baker that temperature is 45 DEG C to be dried, is dried to its water content below 5%,
Crossing 60 mesh sieves, the magnesium stearate after addition step 1) pulverizing, as lubricant, mix homogeneously, is placed in tabletting in tablet machine；
6), compacting tablet use microwave sterilizating, the temperature of microwave is in the range of 90 DEG C, and sterilization time is 3-8 minute.
Embodiment 5
Folium Mori Pupa bombycis chewable tablet, including the raw material of following parts by weight:
38 parts of Folium Mori；
Raw meat dried silkworm chrysalis meal 19 parts is removed in defat；
Chimonin 2.5 parts；
Sucrose 14 parts；
Maltodextrin 9 parts；
Magnesium stearate 8 parts；
Starch 14 parts.
Described Folium Mori are that the step completed is through the Folium Mori processed that complete: (1), purchase is green, do not have pest and disease damage
Folium Mori；(2) complete at a temperature of, completing in 152 DEG C 5 minutes；(3), then in 76 DEG C of steaming and decoctings 10 minutes；(4), do in 61 DEG C of low temperature
Dry to moisture below 5%, knead.
Described defat goes the preparation method of raw meat dried silkworm chrysalis meal to be: (1), fresh silkworm chrysalis sieved, and removes powder, silt, beats
Slurry, obtains Pupa bombycis slurry；Press Pupa bombycis slurry the most again；It is that 1:5 adds water with the weight ratio of water, steaming and decocting 30 minutes under 57 DEG C of constant temperature, remove
Foam and oil slick, then wash by rubbing with the hands in flowing water, until without oil slick and foam impurity, obtaining defat Pupa bombycis in Pupa bombycis slurry loading cloth bag
Slurry；(2), to add defat Pupa bombycis 3 times of volume mass concentration of slurry be the acetum of 75%, then distills 22 minutes in 68 DEG C of constant temperature
After, remove the polyamine compounds in defat Pupa bombycis slurry；Add the spice powder of defat Pupa bombycis slurry weight 0.5 times in 68 DEG C of reactions
31 minutes, remove the raw meats such as the aldehyde in defat Pupa bombycis slurry, ketone and hide composition；(3), last in 64 DEG C of cold drying to moisture 5%
Hereinafter, obtain defat and remove raw meat dried silkworm chrysalis meal.
The described mixture that spice powder is Cortex cinnamomi japonici powder and star aniseed powder, the part by weight of Cortex cinnamomi japonici powder and star aniseed powder is 1:1.
The extracting method of chimonin is with embodiment 1.
The preparation method of Folium Mori Pupa bombycis chewable tablet is:
1), take the chimonin of 2.5 weight portions, the sucrose of 14 weight portions, the maltodextrin of 9 weight portions, the defat of 19 weight portions are gone
The magnesium stearate of raw meat dried silkworm chrysalis meal and 8 weight portions is pulverized respectively, crosses 120 mesh sieves respectively standby；
2), the starch of the Folium Mori and 14 weight portions that take 38 weight portions is placed in mixer mixing 30 minutes, then by above-mentioned mixed powder
It is placed in super micron mill to pulverize, is ground into the superfine powder of 5-8 μm, add the Fructus Hordei Germinatus after step 1) is pulverized to above-mentioned superfine powder and stick with paste
Essence, and be sufficiently mixed, obtain mixed powder A；
3), raw meat dried silkworm chrysalis meal and step 2 are gone in the chimonin after above-mentioned pulverizing, sucrose, defat) in mixed powder A mix and stir
Mix uniformly, obtain mixed powder B；
4), the mixed powder B in step 3) being slowly added to the ethanol water that volumetric concentration is 70%, ethanol addition is with just
Good energy moistening material, crosses 20 mesh sieves, obtains wet grain；
5), by the wet grain of step 4) it is placed in the drying baker that temperature is 45 DEG C to be dried, is dried to its water content below 5%,
Crossing 60 mesh sieves, the magnesium stearate after addition step 1) pulverizing, as lubricant, mix homogeneously, is placed in tabletting in tablet machine；
6), compacting tablet use microwave sterilizating, the temperature of microwave is in the range of 90 DEG C, and sterilization time is 3-8 minute.
Embodiment 6
Folium Mori Pupa bombycis chewable tablet, including the raw material of following parts by weight:
40 parts of Folium Mori；
Raw meat dried silkworm chrysalis meal 20 parts is removed in defat；
Chimonin 3 parts；
Sucrose 15 parts；
Maltodextrin 10 parts；
Magnesium stearate 8 parts；
Starch 15 parts.
Described Folium Mori are that the step completed is through the Folium Mori processed that complete: (1), purchase is green, do not have pest and disease damage
Folium Mori；(2) complete at a temperature of, completing in 160 DEG C 5 minutes；(3), then in 80 DEG C of steaming and decoctings 10 minutes；(4), do in 65 DEG C of low temperature
Dry to moisture below 5%, knead.
Described defat goes the preparation method of raw meat dried silkworm chrysalis meal to be: (1), fresh silkworm chrysalis sieved, and removes powder, silt, beats
Slurry, obtains Pupa bombycis slurry；Press Pupa bombycis slurry the most again；It is that 1:5 adds water with the weight ratio of water, steaming and decocting 30 minutes under 58 DEG C of constant temperature, remove
Foam and oil slick, then wash by rubbing with the hands in flowing water, until without oil slick and foam impurity, obtaining defat Pupa bombycis in Pupa bombycis slurry loading cloth bag
Slurry；(2), to add defat Pupa bombycis 3 times of volume mass concentration of slurry be the acetum of 75%, then distills 20 minutes in 70 DEG C of constant temperature
After, remove the polyamine compounds in defat Pupa bombycis slurry；Add the spice powder of defat Pupa bombycis slurry weight 0.5 times in 70 DEG C of reactions
30 minutes, remove the raw meats such as the aldehyde in defat Pupa bombycis slurry, ketone and hide composition；(3), last in 65 DEG C of cold drying to moisture 5%
Hereinafter, obtain defat and remove raw meat dried silkworm chrysalis meal.
The described mixture that spice powder is Cortex cinnamomi japonici powder and star aniseed powder, the part by weight of Cortex cinnamomi japonici powder and star aniseed powder is 1:1.
The extracting method of chimonin is with embodiment 1.
The preparation method of Folium Mori Pupa bombycis chewable tablet is:
1), take the chimonin of 3 weight portions, raw meat is removed in the sucrose of 15 weight portions, the maltodextrin of 10 weight portions, the defat of 20 weight portions
The magnesium stearate of dried silkworm chrysalis meal and 8 weight portions is pulverized respectively, crosses 120 mesh sieves respectively standby；
2), the starch of the Folium Mori and 15 weight portions that take 40 weight portions is placed in mixer mixing 30 minutes, then by above-mentioned mixed powder
It is placed in super micron mill to pulverize, is ground into the superfine powder of 5-8 μm, add the Fructus Hordei Germinatus after step 1) is pulverized to above-mentioned superfine powder and stick with paste
Essence, and be sufficiently mixed, obtain mixed powder A；
3), raw meat dried silkworm chrysalis meal and step 2 are gone in the chimonin after above-mentioned pulverizing, sucrose, defat) in mixed powder A mix and stir
Mix uniformly, obtain mixed powder B；
4), the mixed powder B in step 3) being slowly added to the ethanol water that volumetric concentration is 70%, ethanol addition is with just
Good energy moistening material, crosses 20 mesh sieves, obtains wet grain；
5), by the wet grain of step 4) it is placed in the drying baker that temperature is 45 DEG C to be dried, is dried to its water content below 5%,
Crossing 60 mesh sieves, the magnesium stearate after addition step 1) pulverizing, as lubricant, mix homogeneously, is placed in tabletting in tablet machine；
6), compacting tablet use microwave sterilizating, the temperature of microwave is in the range of 90 DEG C, and sterilization time is 3-8 minute.
Clinical practice:
Case selection: selected patient just comes hospital for colleges and universities and Middle School Students, government bodies personnel, enterprise's commerce and trade, suburbs, urban district
Examine personnel.Differential diagnosis in tcm syndrome of dampness-heat of liver and gallbladder patient is belonged to through medical.Pill taker 70 people, continues clients 54 after taking medicine first week
People.Wherein 17-26 year 15 people, 27-36 year 18 people, 37-46 year 10 people, 47-56 year 6 people, 57-66 year 5
People, wherein male 40 people, women 14 people.Interviewee 32 people after taking medicine the 4th week.
Administrated method: this medicine is chewable tablet, chews on an empty stomach or one after each meal is chewed most preferably, can early, evening the most once, once take
6 (1g/ sheet).
Diagnostic criteria: it is vexed to coerce swollen gastral cavity, feels sick and detests oil, indigestion and loss of appetite, the jaundice of body mesh and bright and lustrous, yellowish urine, mouth glues bitter taste, stool
Viscous dirty smelly or first knot after half congealed, or drink and few, the limbs spare time weight, fatigue and weakness, yellowish fur, pulse condition stringy and rapid pulse.
Criterion of therapeutical effect: the most effective: spirit takes a turn for the better；Costalgia alleviates, extremity sensation is strong；Stool is normal, mouth the most bitter non-caked,
Light red tongue, normal pulse and, complexion is normal, eating happiness drink.
The most effective: to have taken a turn for the better relative to spirit before diagnosis, extremity are strong than before, defecate the most unobstructed, but
Improving, light red tongue, mouth are the most bitter, wiry and frequent pulse.
The most invalid: spirit, mood are improved inconspicuous, and costalgia, myasthenia of limbs, constipation with dry stool is the most more apparent, red tongue, tongue
Yellow, stringy and rolling pulse.
Observe and result:
Case selection is that to carry out patient at random through differential diagnosis in tcm be syndrome of dampness-heat of liver and gallbladder patient, and to patient, the state of an illness and taking medicine is described
Method.Every patient's medicine taking amount is the dose of 1 week, to the medical patient again returned to after taking medicine a week, according to diagnostic criteria
Diagnose with criterion of therapeutical effect and evaluate, the statistical data of curative effect after taking medicine a week as patient.To being interested in continuing with pill taker, then
To all dose, to the patient again returning to go to a doctor after taking medicine 4 weeks, or doctor in person visits and askes the patient visited, according to
Diagnostic criteria and criterion of therapeutical effect carry out diagnosing, evaluating the statistical data after taking 4 weeks as patient.Its statistical result is as follows:
After patient takes medicine one week, the patient of 17 years old-66 years old divides five groups of totally 54 people, wherein has 1 people in 15 people in 17-26 year
Invalid, 18 people in 27-36 year there are 2 people invalid, 10 people in 37-46 year have 1 people invalid, in three age group 4
People is invalid.Other patients are effective 18 people, effective 32 people, and total effective rate is 92.59%.These group patients continue to take medicine
To the 4th weekend carry out ask visit count on 32 people altogether, wherein 17-26 year group 9 people, 27-36 year group 11 people (wherein have people without
Effect) 37-46 year group 5 people, 47-56 year group 4 people, 57-66 year group 1 people.Effective 27 people, effective 4 people, totally 31 people, the most effectively
Rate is 96.87%.
Model case:
1, Lee so-and-so, female, 37 years old, small enterprise boss, because of the sweet plump taste of long-term surfeit, patient was before one week, and unexpected epigastrium is swollen
Vexed do not relax, extremity fatigue and weak, time sense have expectorant, urine color is like strong tea, and gastral cavity is vexed general to be vomitted, feeling of fullness in the head, and anorexia defecates 2 not
Solving, red tongue, yellowish fur, stringy pulse, start to take Folium Mori HuGanNing tablet, after serveing on 3 weeks, patients symptomatic is clearly better, and continues
Take 1 month to consolidate curative effect.
2, Huang, man, 45 years old, because the operating pressure greatly often phase drinks, irregular eating, yellow skin and eye occurs, thirsty happiness is cold
Drink, big dry stool, yellow urine, irritated, loss of appetite, nausea and vomiting, loose stool, the symptom such as the greasy micro-Huang of thick fur, stringy pulse, it is situated between through friend
Start after continuing to take Folium Mori HuGanNing tablet after one month symptom substantially alleviate, spirit also take a favorable turn, and continues to take 1 month to consolidate
Curative effect.
Claims (6)
1. Folium Mori Pupa bombycis chewable tablet, it is characterised in that: include the raw material of following parts by weight:
Folium Mori 30-40 part；
Raw meat dried silkworm chrysalis meal 15-20 part is gone in defat；
Chimonin 1-3 part；
Sucrose 10-15 part；
Maltodextrin 5-10 part；
Magnesium stearate 5-8 part；
Starch 10-15 part.
Folium Mori Pupa bombycis chewable tablet the most according to claim 1, it is characterised in that: described Folium Mori are to process through completing
Folium Mori, the step completed is: (1), purchase is green, do not have the Folium Mori of pest and disease damage；(2) complete at a temperature of, completing in 150-160 DEG C
5 minutes；(3), then in 75-80 DEG C of steaming and decocting 10 minutes；(4), in 60-65 DEG C of cold drying to moisture below 5%, rub
Twist with the fingers.
Folium Mori Pupa bombycis chewable tablet the most according to claim 1, it is characterised in that: the preparation of raw meat dried silkworm chrysalis meal is gone in described defat
Method is: (1), fresh silkworm chrysalis sieved, and removes powder, silt, making beating, obtains Pupa bombycis slurry；Press Pupa bombycis slurry the most again；Weight with water
Amount ratio add water for 1:5, steaming and decocting 30 minutes, scumming and oil slick under 50-58 DEG C of constant temperature, then by Pupa bombycis slurry loading cloth bag in
Flowing water is washed by rubbing with the hands, until without oil slick and foam impurity, obtaining defat Pupa bombycis slurry；(2) defat Pupa bombycis 2-3 times of volume matter of slurry, is added
Amount concentration is the acetum of 75%, then after 60-70 DEG C of constant temperature distills 20-30 minute, removes the polyamines in defat Pupa bombycis slurry
Compounds；The spice powder adding defat Pupa bombycis slurry weight 0.5 times reacts 30-35 minute in 60-70 DEG C, removes defat Pupa bombycis
Composition hidden by the raw meats such as aldehyde in slurry, ketone；(3), last in 60-65 DEG C of cold drying to moisture below 5%, obtain defat and go
Raw meat dried silkworm chrysalis meal.
Folium Mori Pupa bombycis chewable tablet the most according to claim 3, it is characterised in that: described spice powder is Cortex cinnamomi japonici powder and anise
The part by weight of the mixture of powder, Cortex cinnamomi japonici powder and star aniseed powder is 1:1.
Folium Mori Pupa bombycis chewable tablet the most according to claim 1, it is characterised in that: the extracting method of described chimonin is:
Mangrove bark is ground into coarse powder, weighs 50g coarse powder, be 1:10 according to solid-liquid ratio, add the ethanol solution that mass concentration is 70% and make
For Extraction solvent, microwave power 600 W, extraction time 15min, sucking filtration, and residual with the ethanol solution washing that mass concentration is 70%
Slag, reclaims ethanol, is concentrated into solution 5-10mL, move into separatory funnel, with little water washing and recycling bottle, with chloroform after merging
20mL/ time, chloroform wherein adds 5 10% sodium chloride solutions, extract 3 times, collect water layer, lyophilization, obtain chimonin.
Folium Mori Pupa bombycis chewable tablet the most according to claim 1, it is characterised in that: the preparation method of Folium Mori Pupa bombycis chewable tablet
For:
1) chimonin of 1-3 weight portion, the sucrose of 10-15 weight portion, the maltodextrin of 5-10 weight portion, 15-20 weight portion, are taken
Defat go the magnesium stearate of raw meat dried silkworm chrysalis meal and 5-8 weight portion to pulverize respectively, respectively cross 120 mesh sieves standby；
2), the starch of the Folium Mori and 10-15 weight portion that take 30-40 weight portion is placed in mixer mixing 10-30 minute, then by upper
State mixed powder and be placed in super micron mill pulverizing, be ground into the superfine powder of 5-8 μm, after above-mentioned superfine powder adds step 1) pulverizing
Maltodextrin, and be sufficiently mixed, obtain mixed powder A；
3), raw meat dried silkworm chrysalis meal and step 2 are gone in the chimonin after above-mentioned pulverizing, sucrose, defat) in mixed powder A mix and stir
Mix uniformly, obtain mixed powder B；
4), the mixed powder B in step 3) being slowly added to the ethanol water that volumetric concentration is 70%, ethanol addition is with just
Good energy moistening material, crosses 20 mesh sieves, obtains wet grain；
5), by the wet grain of step 4) it is placed in the drying baker that temperature is 45 DEG C to be dried, is dried to its water content below 5%,
Crossing 60 mesh sieves, the magnesium stearate after addition step 1) pulverizing, as lubricant, mix homogeneously, is placed in tabletting in tablet machine；
6), compacting tablet use microwave sterilizating, the temperature of microwave is in the range of 90 DEG C, and sterilization time is 3-8 minute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610366338.8A CN105902505A (en) | 2016-05-30 | 2016-05-30 | Mulberry leaf and silkworm pupa chewable tablets and preparation method thereof |
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| CN201610366338.8A CN105902505A (en) | 2016-05-30 | 2016-05-30 | Mulberry leaf and silkworm pupa chewable tablets and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108619483A (en) * | 2018-05-22 | 2018-10-09 | 广州人为峰生物科技有限公司 | It is a kind of can balanced diet nutrition hypoglycemic diet silkworm chrysalis extract bioprotein |
| CN109123370A (en) * | 2018-09-04 | 2019-01-04 | 江苏科技大学 | A kind of fermented type wheat bran dietary fiber chewable tablets and its preparation method and application |
| CN110089607A (en) * | 2019-04-22 | 2019-08-06 | 山东圣源绿色食品科技有限公司 | A kind of mulberries pressed candy and preparation method thereof |
| CN110862897A (en) * | 2019-10-29 | 2020-03-06 | 陕西理工大学 | Mulberry leaf and silkworm chrysalis yellow wine and its making process |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108619483A (en) * | 2018-05-22 | 2018-10-09 | 广州人为峰生物科技有限公司 | It is a kind of can balanced diet nutrition hypoglycemic diet silkworm chrysalis extract bioprotein |
| CN108619483B (en) * | 2018-05-22 | 2020-01-14 | 广州人为峰生物科技有限公司 | A biological protein extracted from pupa Bombycis for lowering blood sugar and balancing dietary nutrition |
| CN109123370A (en) * | 2018-09-04 | 2019-01-04 | 江苏科技大学 | A kind of fermented type wheat bran dietary fiber chewable tablets and its preparation method and application |
| CN110089607A (en) * | 2019-04-22 | 2019-08-06 | 山东圣源绿色食品科技有限公司 | A kind of mulberries pressed candy and preparation method thereof |
| CN110862897A (en) * | 2019-10-29 | 2020-03-06 | 陕西理工大学 | Mulberry leaf and silkworm chrysalis yellow wine and its making process |
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