CN105891283B - Drug effect quantization device and method for elemene - Google Patents
Drug effect quantization device and method for elemene Download PDFInfo
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- CN105891283B CN105891283B CN201610161504.0A CN201610161504A CN105891283B CN 105891283 B CN105891283 B CN 105891283B CN 201610161504 A CN201610161504 A CN 201610161504A CN 105891283 B CN105891283 B CN 105891283B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
Abstract
The invention discloses a kind of drug effect quantization device and method for elemene, the present invention compares the signal-to-noise ratio peak of the elemene of unknown drug effect with the signal-to-noise ratio peak of common cancer treatment drugs cis-platinum, under the reference of the cis-platinum of clear and definite drug effect and dose, the drug effect and dose of elemene are obtained.The present invention has that detection efficiency is high, accuracy is good, is used safely for elemene and provides reliable basis, it is ensured that the characteristics of patient safety.
Description
Technical field
The present invention relates to medicine effect detection technique field, more particularly, to it is a kind of can accurately detect drug effect be used for olive
The drug effect quantization device and method of fragrant alkene.
Background technology
The dosage of cancer therapy drug must be accurate, when dose is insufficient, can not reach therapeutic effect.When dose is beyond safety
Dosage, then can cause the gastrointestinal reactions such as anorexia, nausea,vomiting,diarrhea.Common and serious toxic reaction is kidney poison
Property reaction, repeated drug taking can aggravate reaction of renal toxicity, and major determinant kidney proximal tubule, makes Vacuole formation, exuviation, tube chamber
, there is hyalina, uric acid is excessive in blood, and the symptoms such as blood urine can be caused when serious in expansion.
When heavy dose and repeatedly medication, it may appear that neurotoxicity, can damage the hair cell that ear Ke replaces mouthpart, cause height
Frequency, which loses, to be listened.
The drug effect of anti-cancer drugs does not have clinical data may be referred to, and initial stage gropes to judge in use, fully relying on doctor,
If dose is insufficient, therapeutic effect is not reached；If dose can cause serious toxic reaction beyond safe dose, it can give and suffer from
Person's body brings very major injury.
The content of the invention
The goal of the invention of the present invention is to overcome the shortcomings of that the drug effect of anti-cancer drugs of the prior art is unknown, there is provided
A kind of drug effect quantization device and method for elemene that can accurately detect drug effect.
To achieve these goals, the present invention uses following technical scheme：
A kind of drug effect quantization device for elemene, including operating platform, the electrochemical operation on operating platform
Stand, flow cell and adjustable for height support arm, 2 pieces of substrates in flow cell, the electrode chip on every piece of substrate, if
In two montants on flow cell；Support arm, which is equipped with, to be filled the first solution transfusion bottle of cleaning solution, fills elemene solution
Second solution transfusion bottle, the first solution transfusion bottle lower part are equipped with the first micro pump of unicom, and the second solution transfusion bottle lower part is equipped with unicom
The liquid outlet of second micro pump, the first micro pump and the second micro pump connects with the spiral catheter on two montants
Connect；Each electrode chip includes being connected with electrochemical workstation electric to electrode, reference electrode and working electrode, each work
Culture has several cancer cells on extremely, and flow cell is equipped with drain lid, and drain, which covers, is equipped with several delivery holes, flow cell
Lower part is equipped with outlet tube；The catheter outer circumferential surface is equipped with heating film；It is electrochemical workstation, the first micro pump, second micro
Pump and heating film are with calculating mechatronics.
When elemene solution is dripped on cancer cell, cancer cell can react, the electric current that electrochemical workstation detects
Respective change can occur for density signal, and detection signal Spect (t) inputs of detected new drug are pre-stored in computer by the present invention
In two layers of stochastic resonance system in, computer draws the signal-to-noise ratio spectrogram of excitation noise signal, is chosen in signal-to-noise ratio spectrogram
Close to the signal-to-noise ratio peak of the characteristic peak of origin, and by the coordinate (M of signal-to-noise ratio peak1, M2) storage is into computer, computer
In be stored with the characteristic peaks coordinate (W of cis-platinum1, W2)；
Work as M1＜ W1And | M2| ＞ | W2|, Computer display elemene to the action effect of cancer cell than cis-platinum good, elemi
The dosage of alkene needs to reduce than cis-platinum；
Work as M1＞ W1And | M2| ＜ | W2| when, Computer display elemene is poorer than cis-platinum to the action effect of cancer cell, olive
The dosage of fragrant alkene is needed than cis-platinum increase.
The signal-to-noise ratio peak and the signal-to-noise ratio of common cancer treatment drugs cis-platinum of elemene of the invention by unknown drug effect
Peak value compares, and under the reference of the cis-platinum of clear and definite drug effect and dose, obtains the drug effect and dose of elemene, pacifies for elemene
Full use provides reliable basis, it is ensured that the safety of patient.
Preferably, the support arm includes the armstand being connected with operating platform and the horizontal arm arranged on armstand upper end, the
Hanging piece is equipped with one solution transfusion bottle and the second solution transfusion bottle；Each hanging piece includes annular canister, arranged on the bottom of annular canister lower end
Plate and two vertical connecting rods arranged on annular canister upper end；It is equipped with each bottom plate and is hung with the first solution transfusion bottle or the second solution
The corresponding perforate of bottle neck of bottle；Horizontal arm is connected with each vertical connecting rod upper end.
Preferably, the armstand includes inner sleeve and the outer tube being connected with inner sleeve, inner sleeve is equipped with several
Elastic bumps, outer tube are equipped with and several corresponding through holes of elastic bumps.
Preferably, flow cell includes housing, the cover board on housing and the sealing on cover board of upper end opening
Circle, sealing ring lower surface be connected with to the base plate seals on the outside of electrode, working electrode and to the substrate between electrode equipped with leading to
Hole.
A kind of method of drug effect quantization device for elemene, includes the following steps：
Support arm is adjusted to suitable height, computer control heating film electrified regulation, the first micro pump and dripped by (5-1)
Cleaning solution, cleaning solution are heated when flowing through catheter, and the first micro pump dropping liquid is after 15 to 25 minutes, computer control first
Micro pump stops dropping liquid；
(5-2) computer controls the second micro pump to drip elemene solution, and the second micro pump dropping liquid is after 12 to 15 minutes, meter
2 current density signal S of calculation machine collection electrochemical workstation detection1(t), S2(t), computer calculates and obtains S1(t), S2
(t) average signal, current density signal S (t) is defined as by average signal；
Computer controls the current density signal S (t) of the second micro pump computer acquisition electrochemical workstation detection, calculates
Machine chooses the sampled value that several time intervals are Δ t in current density signal S (t), and each sampled value is according to time order and function
Order is arranged to make up detection signal ES (t)；
(5-3) is for first sampled value in ES (t) and each sampled value ES (t outside last sampled value1), profit
Use formulaCalculate steady coefficient ratio；
The weight threshold 0.55,1 and 1.45 being sequentially increased is previously provided with computer；
It is located at the sampled value in the range of [1-A1,1+A1] for ratio, sampled value is modified to B1 ES (t1), B1 is small
In 0.4 real number；
It is located at the sampled value in the range of (0.55,1-A1) or (1+A1,1.45) for ratio, sampled value is modified to B2
ES(t1), B1 ＜ B2 ＜ 0.6；
(5-4) replaces the correspondence sampled value in ES (t) with corrected each sampled value, obtains believing by modified detection
Number Spect (t),
In two layers of stochastic resonance system that Spect (t) inputs are pre-stored in computer, computer draws excitation noise letter
Number signal-to-noise ratio spectrogram, the signal-to-noise ratio peak of the characteristic peak close to origin is chosen in signal-to-noise ratio spectrogram, and by signal-to-noise ratio peak
Coordinate (M1, M2) store the characteristic peaks coordinate (W that cis-platinum is stored with into computer, in computer1, W2)；
(5-5) works as M1＜ W1And | M2| ＞ | W2|, Computer display elemene compares cis-platinum to the action effect of cancer cell
Good, the dosage of elemene needs to reduce than cis-platinum；
Work as M1＞ W1And | M2| ＜ | W2| when, Computer display elemene is poorer than cis-platinum to the action effect of cancer cell, olive
The dosage of fragrant alkene is needed than cis-platinum increase.
Preferably, in two layers of stochastic resonance system that Spect (t) inputs are pre-stored in computer, computer
The signal-to-noise ratio spectrogram for drawing excitation noise signal includes the following steps：
Spect (t) is inputted one layer of accidental resonance model by computer
In, wherein, V (x, t) is potential function, and x (t) is Brownian movement Particles Moving lopcus function, and a, b, c, d are setting
Constant, ξ (t) are outer noises, and D is outer noise intensity, and N (t) grasps noise to be interior,For periodic sinusoidal signal, A
It is signal amplitude, f is signal frequency, and t is run duration,For phase, if
cx2-dx4To demarcate component；
Computer calculate V (x, t) for x first derivative and second dervative, and make equation be equal to 0, obtain two layers with
Machine resonance model：
Noise intensity D=0 is set,Spect (t)=0, N (t)=0；The critical value of A is calculated
For
The critical value of A is substituted into one layer of accidental resonance model, and sets X0(t)=0, sn0=0, with quadravalence jade for asking rain Ge Kuta
One layer of accidental resonance model of Algorithm for Solving, obtainsAnd calculate
Wherein, xn(t) the n order derivatives for being x (t), snn-1It is value of the n-1 order derivatives of S (t) at t=0, snn+1It is S
(t) value of the n+1 order derivatives at t=0, n=0,1 ..., N-1；Obtain x1(t), x2(t) ..., xn+1(t) value；
Computer is to x1(t), x2(t) ..., xn+1(t) integrated, obtain x (t), and it is random common at one layer to obtain x (t)
Two layers of stochastic resonance system that model and two layers of accidental resonance model form of shaking produce the position x at accidental resonance momentmValue and xm
Corresponding resonance moment t1And and t1Corresponding noise D1, D1For a value in D；
Computer utilizes formulaCalculate the letter of two layers of stochastic resonance system output
Make an uproar ratio；Wherein, Δ U=a2/4b；Computer draws the signal-to-noise ratio spectrogram of excitation noise signal.
Preferably, further including the blender (15) in the second solution transfusion bottle lower part, blender is electrically connected with computer
Connect；Further included between step (5-1) and (5-2) after computer control blender stirs 12 to 14 minutes and stop stirring.
Preferably, further including the temperature sensor (16) on catheter, temperature sensor is with calculating mechatronics；
Further include following steps：
Temperature sensor detects the temperature of catheter, and normal temperature section [T is equipped with computerL, TH], when the temperature of detection
Degree >=TH, computer control heating film stopping heating；As temperature≤T of detectionL, computer control heating film begin to warm up.
Preferably, further include following steps after step (5-5)：
WhenWhen, Computer display it is recommended to increase or reduction dose be 3% to 20%；
WhenWhen, Computer display it is recommended to increase or reduction dose be 20% to 35%；
WhenWhen, Computer display it is recommended to increase or reduction dose be more than 35%.
Preferably, the value range of A1 is 0.14 to 0.32；The value range of B1 is the value model of 0.2 to 0.28, B2
Enclose for 0.32 to 0.48.
Therefore, the present invention has the advantages that：Detection efficiency is high, accuracy is good, is provided for elemene safe handling
Reliable basis, it is ensured that the safety of patient.
Brief description of the drawings
Fig. 1 is a kind of structure diagram of the present invention.
Fig. 2 is the principle of the present invention block diagram；
Fig. 3 is a kind of structure diagram of the electrode chip of the present invention；
Fig. 4 is a kind of flow chart of the embodiment of the present invention；
Fig. 5 is a kind of signal-to-noise ratio spectrogram of the cis-platinum of the present invention；
Fig. 6 is a kind of structure diagram of the drain lid of the present invention.
In figure：Operating platform 1, electrochemical workstation 2, flow cell 3, support arm 4, substrate 5, electrode chip 6, montant 7,
One solution transfusion bottle 8, the second solution transfusion bottle 9, the first micro pump 10, the second micro pump 11, catheter 12, computer 13, hanging piece 14,
Blender 15, temperature sensor 16, drain lid 17, delivery hole 18, outlet tube 31, armstand 41, horizontal arm 42, through hole 51, paint
Coating 52, to electrode 61, reference electrode 62, working electrode 63, heating film 121, annular canister 141, vertical connecting rod 142, inner sleeve
Pipe 411, outer tube 412.
Embodiment
The present invention will be further described with reference to the accompanying drawings and detailed description.
Embodiment as shown in Figure 1, Figure 2, Figure 3 shows is a kind of drug effect quantization device for elemene, including operating platform
1, electrochemical workstation 2, flow cell 3 and adjustable for height support arm 4 on operating platform, 2 pieces in flow cell
Substrate 5, the electrode chip 6 on every piece of substrate, two montants 7 on flow cell；Support arm is equipped with and fills cleaning
First solution transfusion bottle 8 of solution, the second solution transfusion bottle 9 for filling elemene solution, the first solution transfusion bottle lower part are equipped with unicom
First micro pump 10, second micro pump 11 of the second solution transfusion bottle lower part equipped with unicom, the first micro pump and the second micro pump
Liquid outlet is connected with the spiral catheter 12 on two montants；Each electrode chip includes and electrochemical operation
Stand connection to electrode 61, reference electrode 62 and working electrode 63, culture has 30000 cancer cells on each working electrode,
Flow cell lower part is equipped with outlet tube 31；Catheter outer circumferential surface is equipped with heating film 121.
As shown in fig. 6, drain lid 17 is equipped with the corresponding flow cell in catheter lower end, with working electrode and to electrode
Between corresponding drain cover equipped with 8 delivery holes 18, drain lid edge is equipped with annular vertical edge.
As shown in Fig. 2, electrochemical workstation, the first micro pump, the second micro pump and heating film are electrically connected with computer 13
Connect.Each substrate is made of golden material.
As shown in figure 3, each electrode chip include being connected with electrochemical workstation to electrode 61, reference electrode 62 and
Working electrode 63, further includes painting layer 52.
As shown in Figure 1, support arm includes the armstand 41 being connected with operating platform and the horizontal arm 42 arranged on armstand upper end, the
Hanging piece 14 is equipped with one solution transfusion bottle and the second solution transfusion bottle；Each hanging piece includes annular canister 141, arranged on annular canister lower end
Bottom plate and two vertical connecting rods 142 arranged on annular canister upper end；It is equipped with each bottom plate and the first solution transfusion bottle or the
The corresponding perforate of bottle neck of two solution transfusion bottles；Horizontal arm is connected with each vertical connecting rod upper end.
Armstand includes inner sleeve 411 and the outer tube 412 being connected with inner sleeve, and it is convex that inner sleeve is equipped with several elasticity
Rise, outer tube is equipped with and several corresponding through holes of elastic bumps.
Flow cell includes housing, the cover board on housing and the sealing ring on cover board of upper end opening, sealing ring
Lower surface is connected with to the base plate seals on the outside of electrode, working electrode and is equipped with through hole 51 to the substrate between electrode.
As shown in figure 4, a kind of method of drug effect quantization device for elemene, includes the following steps：
Computer controls two blenders to stop stirring after stirring 14 minutes；
Step 100, preheat, clean
Support arm is adjusted to suitable height, temperature sensor and detects the temperature of catheter, standard is equipped with computer
Temperature range [TL, TH], as temperature >=T of detectionH, computer control heating film stopping heating；As temperature≤T of detectionL, meter
Calculation machine control heating film is begun to warm up；TL=36.5 DEG C, TH=39.6 DEG C；
First micro pump drips cleaning solution, and cleaning solution is heated when flowing through catheter, and the first micro pump dropping liquid 25 divides
Zhong Hou, computer control the first micro pump to stop dropping liquid；Cleaning solution is phosphate buffer；Computer control blender stirring
Stop stirring after ten minutes；
Step 200, detect
Computer controls the second micro pump to drip elemene solution, after the second micro pump dropping liquid 15 minutes, computer acquisition
2 current density signal S of electrochemical workstation detection1(t), S2(t), computer calculates and obtains S1(t), S2(t) be averaged
Signal, current density signal S (t) is defined as by average signal；The current density letter of computer acquisition electrochemical workstation detection
Number S (t), computer choose the sampled value that several time intervals are Δ t in current density signal S (t), and each sampled value is pressed
Detection signal ES (t) is arranged to make up according to time order and function order；
Step 300, data correction is handled
For first sampled value in ES (t) and each sampled value ES (t outside last sampled value1), utilize public affairs
FormulaCalculate steady coefficient ratio；
The weight threshold 0.55,1 and 1.45 being sequentially increased is previously provided with computer；
It is located at the sampled value in the range of [1-A1,1+A1] for ratio, sampled value is modified to B1 ES (t1), A1 is
0.25, B1 0.28；
It is located at the sampled value in the range of (0.55,1-A1) or (1+A1,1.45) for ratio, sampled value is modified to B2
ES(t1), B2 0.48；
Step 400, the signal-to-noise ratio peak at selected characteristic peak
The correspondence sampled value in ES (t) is replaced with corrected each sampled value, is obtained by modified detection signal
Spect (t),
Spect (t) is inputted one layer of accidental resonance model by computer
In, wherein, V (x, t) is potential function, and x (t) is Brownian movement Particles Moving lopcus function, and a, b, c, d are setting
Constant, ξ (t) are outer noises, and D is outer noise intensity, and N (t) grasps noise to be interior,For periodic sinusoidal signal, A
It is signal amplitude, f is signal frequency, and t is run duration,For phase, if
cx2-dx4To demarcate component；
Computer calculate V (x, t) for x first derivative and second dervative, and make equation be equal to 0, obtain two layers with
Machine resonance model：
Noise intensity D=0 is set,Spect (t)=0, N (t)=0；The critical value of A is calculated
For
The critical value of A is substituted into one layer of accidental resonance model, and sets X0(t)=0, sn0=0, with quadravalence jade for asking rain Ge Kuta
One layer of accidental resonance model of Algorithm for Solving, obtainsAnd calculate
Wherein, xn(t) the n order derivatives for being x (t), snn-1It is value of the n-1 order derivatives of S (t) at t=0, snn+1It is S
(t) value of the n+1 order derivatives at t=0, n=0,1 ..., N-1；Obtain x1(t), x2(t) ..., xn+1(t) value；
Computer is to x1(t), x2(t) ..., xn+1(t) integrated, obtain x (t), and it is random common at one layer to obtain x (t)
Two layers of stochastic resonance system that model and two layers of accidental resonance model form of shaking produce the position x at accidental resonance momentmValue and xm
Corresponding resonance moment t1And and t1Corresponding noise D1, D1For a value in D；
Computer utilizes formulaCalculate the letter of two layers of stochastic resonance system output
Make an uproar ratio；Wherein, Δ U=a2/4b；Computer draws the signal-to-noise ratio spectrogram of excitation noise signal.
The signal-to-noise ratio peak of the characteristic peak close to origin is chosen in signal-to-noise ratio spectrogram, and by the coordinate of signal-to-noise ratio peak
(M1, M2) store the characteristic peaks coordinate (W that cis-platinum is stored with into computer, in computer1, W2)；
Step 500, make drug effect and dose judges
Work as M1＜ W1And | M2| ＞ | W2|, Computer display elemene to the action effect of cancer cell than cis-platinum good, elemi
The dosage of alkene needs to reduce than cis-platinum；
Work as M1＞ W1And | M2| ＜ | W2| when, Computer display elemene is poorer than cis-platinum to the action effect of cancer cell, olive
The dosage of fragrant alkene is needed than cis-platinum increase；
WhenWhen, Computer display it is recommended to increase or reduction dose be 3% to 20%；
WhenWhen, Computer display it is recommended to increase or reduction dose be 20% to 35%；
WhenWhen, Computer display it is recommended to increase or reduction dose be more than 35%.
Characteristic peaks coordinate (the W of cis-platinum1, W2) step 100 using the present invention to 400 detection cisplatin solutions obtain, respectively
The cisplatin solution being contained in 2 the second solution transfusion bottles is identical with elemene concentration.
As shown in figure 5, the signal-to-noise ratio peak of the characteristic peak of cis-platinum is (20, -34dB), the characteristic peak of elemene of the invention
Signal-to-noise ratio peak be (10, -38dB)；
Then Computer display elemene is better than cis-platinum to the action effect of cancer cell, and the dosage of elemene needs to compare cis-platinum
The information of reduction；AndTherefore, it can suggest that dose reduces 30%.
It is to be understood that the present embodiment is only illustrative of the invention and is not intended to limit the scope of the invention.In addition, it should also be understood that,
After having read the content of the invention lectured, those skilled in the art can make various modifications or changes to the present invention, these etc.
Valency form is also fallen within the scope of the appended claims of the present application.
Claims (9)
1. a kind of method of drug effect quantization device for elemene, the drug effect quantization device for elemene includes operating platform
(1), the electrochemical workstation on operating platform (2), flow cell (3) and adjustable for height support arm (4), arranged on flow cell
2 pieces of interior substrates (5), the electrode chip (6) on every piece of substrate, two montants (7) on flow cell；On support arm
Equipped with filling the first solution transfusion bottle (8) of cleaning solution, filling the second solution transfusion bottle (9) of elemene solution, the first solution is hung
First micro pump (10) of the bottle lower part equipped with unicom, second micro pump (11) of the second solution transfusion bottle lower part equipped with unicom, first
The liquid outlet of micro pump and the second micro pump is connected with the spiral catheter (12) on two montants；Each electrode
Chip with electrochemical workstation including being connected to electrode (61), reference electrode (62) and working electrode (63), each work
Culture has several cancer cells on electrode, and flow cell is equipped with drain lid (17), and drain, which covers, is equipped with several delivery holes
(18), flow cell lower part is equipped with outlet tube (31)；The catheter outer circumferential surface is equipped with heating film (121)；Electrochemical workstation,
First micro pump, the second micro pump and heating film are electrically connected with computer (13)；It is characterized in that include the following steps：
(1-1) adjusts support arm to suitable height, computer control heating film electrified regulation, and the first micro pump drips cleaning
Solution, cleaning solution are heated when flowing through catheter, and for the first micro pump dropping liquid after 15 to 25 minutes, computer control first is micro
Pump stops dropping liquid；
(1-2) computer controls the second micro pump to drip elemene solution, and the second micro pump dropping liquid is after 12 to 15 minutes, computer
Gather 2 current density signal S of electrochemical workstation detection1(t), S2(t), computer calculates and obtains S1(t), S2(t)
Average signal, current density signal S (t) is defined as by average signal；
Computer controls the current density signal S (t) of the second micro pump computer acquisition electrochemical workstation detection, and computer exists
The sampled value that several time intervals are Δ t is chosen in current density signal S (t), each sampled value is according to time order and function order
It is arranged to make up detection signal ES (t)；
(1-3) is for first sampled value in ES (t) and each sampled value ES (t outside last sampled value1), utilize public affairs
FormulaCalculate steady coefficient ratio；
The weight threshold 0.55,1 and 1.45 being sequentially increased is previously provided with computer；
It is located at the sampled value in the range of [1-A1,1+A1] for ratio, sampled value is modified to B1 ES (t1), B1 is less than 0.4
Real number；
It is located at the sampled value in the range of (0.55,1-A1) or (1+A1,1.45) for ratio, sampled value is modified to B2 ES
(t1),
(1-4) replaces the correspondence sampled value in ES (t) with corrected each sampled value, obtains by modified detection signal
Spect (t),
In two layers of stochastic resonance system that Spect (t) inputs are pre-stored in computer, computer draws excitation noise signal
Signal-to-noise ratio spectrogram, chooses the signal-to-noise ratio peak of the characteristic peak close to origin in signal-to-noise ratio spectrogram, and by the seat of signal-to-noise ratio peak
Mark (M1, M2) store the characteristic peaks coordinate (W that cis-platinum is stored with into computer, in computer1, W2)；
(1-5) whenAnd | M2| ＞ | W2|, Computer display elemene to the action effect of cancer cell than cis-platinum good, olive
The dosage of fragrant alkene needs to reduce than cis-platinum；
Work as M1＞ W1AndWhen, Computer display elemene is poorer than cis-platinum to the action effect of cancer cell, elemene
Dosage is needed than cis-platinum increase.
2. the method for the drug effect quantization device according to claim 1 for elemene, it is characterized in that, the support arm bag
The armstand (41) being connected with operating platform and the horizontal arm (42) arranged on armstand upper end are included, the first solution transfusion bottle and the second solution are hung
Hanging piece (14) is equipped with bottle；Each hanging piece includes annular canister (141), arranged on the bottom plate of annular canister lower end and arranged on annular canister
The vertical connecting rod (142) of two of upper end；The bottle neck with the first solution transfusion bottle or the second solution transfusion bottle is equipped with each bottom plate
Corresponding perforate；Horizontal arm is connected with each vertical connecting rod upper end.
3. the method for the drug effect quantization device according to claim 2 for elemene, it is characterized in that, the armstand includes
Inner sleeve (411) and the outer tube (412) being connected with inner sleeve, inner sleeve are equipped with several elastic bumps, are set on outer tube
Have and several corresponding through holes of elastic bumps.
4. the method for the drug effect quantization device according to claim 1 for elemene, it is characterized in that, flow cell includes upper
The housing of end opening, the cover board on housing and the sealing ring on cover board, sealing ring lower surface with to electrode on the outside of
Base plate seals connect, and working electrode and are equipped with through hole (51) to the substrate between electrode.
5. the method for the drug effect quantization device according to claim 1 for elemene, it is characterized in that,
In two layers of stochastic resonance system that Spect (t) inputs are pre-stored in computer, computer draws excitation noise letter
Number signal-to-noise ratio spectrogram include the following steps：
Spect (t) is inputted one layer of accidental resonance model by computer
In, wherein, V (x, t) is potential function, and x (t) is Brownian movement Particles Moving lopcus function, and a, b, c, d are the normal of setting
Number, ξ (t) are outer noises, and D is outer noise intensity, and N (t) grasps noise to be interior,For periodic sinusoidal signal, A is
Signal amplitude, f are signal frequencies, and t is run duration,For phase, if
cx2-dx4To demarcate component；
Computer calculates first derivative and second dervative of the V (x, t) for x, and equation is equal to 0, obtains two layers at random altogether
Shake model：
Noise intensity D=0 is set,Spect (t)=0, N (t)=0；The critical value that A is calculated is
The critical value of A is substituted into one layer of accidental resonance model, and sets X0(t)=0, sn0=0, with quadravalence jade for asking rain Ge Kuta algorithms
One layer of accidental resonance model is solved, is obtainedAnd calculate
Wherein, xn(t) the n order derivatives for being x (t), snn-1It is value of the n-1 order derivatives of S (t) at t=0, snn+1It is the n+ of S (t)
Value of 1 order derivative at t=0, n=0,1 ..., N-1；Obtain x1(t), x2(t) ..., xn+1(t) value；
Computer is to x1(t), x2(t) ..., xn+1(t) integrated, obtain x (t), and obtain x (t) in one layer of accidental resonance mould
Two layers of stochastic resonance system of type and two layers of accidental resonance model composition produce the position x at accidental resonance momentmValue and xmRelatively
The resonance moment t answered1And and t1Corresponding noise D1, D1For a value in D；
Computer utilizes formula
Calculate two layers of stochastic resonance system output
Signal-to-noise ratio；Wherein, Δ U=a2/4b；Computer draws the signal-to-noise ratio spectrogram of excitation noise signal.
6. the method for the drug effect quantization device according to claim 1 for elemene, it is characterized in that, further include arranged on
Blender (15) in two solution transfusion bottle lower parts, blender is with calculating mechatronics；Further included between step (1-1) and (1-2)
Computer control blender stops stirring after stirring 12 to 14 minutes.
7. the method for the drug effect quantization device according to claim 1 for elemene, it is characterized in that, further include to be arranged on and lead
Temperature sensor (16) in liquid pipe, temperature sensor is with calculating mechatronics；Further include following steps：
Temperature sensor detects the temperature of catheter, is equipped with normal temperature section [36.5 DEG C, 39.5 DEG C] in computer, works as detection
Temperature >=39.5 DEG C, computer control heating film stop heating；When temperature≤36.5 DEG C of detection, computer control heating film
Begin to warm up.
8. the method for the drug effect quantization device according to claim 1 for elemene, it is characterized in that, step (1-5) it
After further include following steps：
WhenWhen, Computer display it is recommended to increase or reduction dose be 3% to 20%；
WhenWhen, Computer display it is recommended to increase or reduction dose be 20% to 35%；
WhenWhen, Computer display it is recommended to increase or reduction dose be more than 35%.
9. the method for the drug effect quantization device for elemene according to claim 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8,
It is characterized in that the value range of A1 is 0.14 to 0.32；The value range that the value range of B1 is 0.2 to 0.28, B2 is 0.32
To 0.48.
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Citations (3)
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| CN2843484Y (en) * | 2005-11-25 | 2006-12-06 | 亓淑玲 | Portable transfusion bracket |
| CN102559483A (en) * | 2012-01-11 | 2012-07-11 | 浙江大学 | Device and method for real-time monitoring of behaviors and states of cells |
| CN103191108A (en) * | 2013-04-10 | 2013-07-10 | 中山火炬职业技术学院 | Anti-cancer pellet and colonic targeting agent |
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| US7732127B2 (en) * | 2002-12-20 | 2010-06-08 | Acea Biosciences, Inc. | Dynamic monitoring of cell adhesion and spreading using the RT-CES system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2843484Y (en) * | 2005-11-25 | 2006-12-06 | 亓淑玲 | Portable transfusion bracket |
| CN102559483A (en) * | 2012-01-11 | 2012-07-11 | 浙江大学 | Device and method for real-time monitoring of behaviors and states of cells |
| CN103191108A (en) * | 2013-04-10 | 2013-07-10 | 中山火炬职业技术学院 | Anti-cancer pellet and colonic targeting agent |
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| Tastant quantitative analysis from complex mixtures using taste cell-based sensor and double-layered cascaded series stochastic resonance;Guohua Hui等;《Electrochimica Acte》;20140521;第75-88页 * |
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