CN105823815B - Anticancer drug docetaxel Composition analyzed device and detection method - Google Patents
Anticancer drug docetaxel Composition analyzed device and detection method Download PDFInfo
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- CN105823815B CN105823815B CN201610003087.7A CN201610003087A CN105823815B CN 105823815 B CN105823815 B CN 105823815B CN 201610003087 A CN201610003087 A CN 201610003087A CN 105823815 B CN105823815 B CN 105823815B
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- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 title claims abstract description 51
- 229960003668 docetaxel Drugs 0.000 title claims abstract description 51
- 238000001514 detection method Methods 0.000 title claims abstract description 32
- 239000000203 mixture Substances 0.000 title claims abstract description 21
- 239000002246 antineoplastic agent Substances 0.000 title claims abstract description 20
- 229940041181 antineoplastic drug Drugs 0.000 title claims abstract description 20
- 229910052697 platinum Inorganic materials 0.000 claims abstract description 29
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims abstract description 29
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 16
- 201000011510 cancer Diseases 0.000 claims abstract description 16
- 239000007788 liquid Substances 0.000 claims description 34
- 238000004140 cleaning Methods 0.000 claims description 11
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- 230000005284 excitation Effects 0.000 claims description 9
- 239000000758 substrate Substances 0.000 claims description 9
- 238000007789 sealing Methods 0.000 claims description 6
- 238000004364 calculation method Methods 0.000 claims description 4
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- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000010977 jade Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 230000000737 periodic effect Effects 0.000 claims description 3
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- 238000003756 stirring Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims 24
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 238000007689 inspection Methods 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 230000000857 drug effect Effects 0.000 abstract description 9
- 229940079593 drug Drugs 0.000 abstract description 5
- 239000003814 drug Substances 0.000 abstract description 5
- 210000004027 cell Anatomy 0.000 description 24
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
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- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
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- 231100000331 toxic Toxicity 0.000 description 2
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- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010029350 Neurotoxicity Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010044221 Toxic encephalopathy Diseases 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000002768 hair cell Anatomy 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 231100000417 nephrotoxicity Toxicity 0.000 description 1
- 231100000228 neurotoxicity Toxicity 0.000 description 1
- 230000007135 neurotoxicity Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
Claims (9)
Priority Applications (1)
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CN201610003087.7A CN105823815B (en) | 2016-01-04 | 2016-01-04 | Anticancer drug docetaxel Composition analyzed device and detection method |
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CN201610003087.7A CN105823815B (en) | 2016-01-04 | 2016-01-04 | Anticancer drug docetaxel Composition analyzed device and detection method |
Publications (2)
Publication Number | Publication Date |
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CN105823815A CN105823815A (en) | 2016-08-03 |
CN105823815B true CN105823815B (en) | 2018-06-26 |
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CN201610003087.7A Active CN105823815B (en) | 2016-01-04 | 2016-01-04 | Anticancer drug docetaxel Composition analyzed device and detection method |
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Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1309295A (en) * | 2000-12-04 | 2001-08-22 | 浙江大学 | Multifunctional cytomicrophysiological meter for screening medicines |
CN101158677A (en) * | 2007-10-29 | 2008-04-09 | 浙江大学 | Cell electric physiology integrated chip and preparation method |
CN101441178A (en) * | 2005-07-15 | 2009-05-27 | 北京吉天仪器有限公司 | Flow injection colorimetry cyanogen measuring instrument for measuring cyanide content |
CN101678356A (en) * | 2007-04-06 | 2010-03-24 | 加利福尼亚技术学院 | Microfluidic device |
CN201503435U (en) * | 2009-09-08 | 2010-06-09 | 上海新拓分析仪器科技有限公司 | Multichannel flow chemical analysis system suitable to be mounted on vehicle |
CN102242181A (en) * | 2011-04-28 | 2011-11-16 | 中国烟草总公司郑州烟草研究院 | Flue gas condensate cytotoxicity determination method based on cell electronic sensor |
CN102375068A (en) * | 2010-08-20 | 2012-03-14 | 北京吉天仪器有限公司 | Full-automatic nutrient salt analyzer and analysis method thereof |
CN102382758A (en) * | 2011-10-14 | 2012-03-21 | 杭州电子科技大学 | Three-dimensional cell chip based on cell printing and multi-parameter sensing array integrated technology |
CN104089996A (en) * | 2014-01-17 | 2014-10-08 | 浙江工商大学 | Taste cell sensor using surface acoustic wave resonator and preparation method thereof |
CN204008441U (en) * | 2014-06-06 | 2014-12-10 | 孙璐 | Online constant temperature auto injection gas phase molecular absorption spectrometer |
-
2016
- 2016-01-04 CN CN201610003087.7A patent/CN105823815B/en active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1309295A (en) * | 2000-12-04 | 2001-08-22 | 浙江大学 | Multifunctional cytomicrophysiological meter for screening medicines |
CN101441178A (en) * | 2005-07-15 | 2009-05-27 | 北京吉天仪器有限公司 | Flow injection colorimetry cyanogen measuring instrument for measuring cyanide content |
CN101678356A (en) * | 2007-04-06 | 2010-03-24 | 加利福尼亚技术学院 | Microfluidic device |
CN101158677A (en) * | 2007-10-29 | 2008-04-09 | 浙江大学 | Cell electric physiology integrated chip and preparation method |
CN201503435U (en) * | 2009-09-08 | 2010-06-09 | 上海新拓分析仪器科技有限公司 | Multichannel flow chemical analysis system suitable to be mounted on vehicle |
CN102375068A (en) * | 2010-08-20 | 2012-03-14 | 北京吉天仪器有限公司 | Full-automatic nutrient salt analyzer and analysis method thereof |
CN102242181A (en) * | 2011-04-28 | 2011-11-16 | 中国烟草总公司郑州烟草研究院 | Flue gas condensate cytotoxicity determination method based on cell electronic sensor |
CN102382758A (en) * | 2011-10-14 | 2012-03-21 | 杭州电子科技大学 | Three-dimensional cell chip based on cell printing and multi-parameter sensing array integrated technology |
CN104089996A (en) * | 2014-01-17 | 2014-10-08 | 浙江工商大学 | Taste cell sensor using surface acoustic wave resonator and preparation method thereof |
CN204008441U (en) * | 2014-06-06 | 2014-12-10 | 孙璐 | Online constant temperature auto injection gas phase molecular absorption spectrometer |
Non-Patent Citations (1)
Title |
---|
Tastant quantitative analysis from complex mixtures using taste cell-based sensor and double-layered cascaded series stochastic resonance;Guohua Hui等;《Electrochimica Acte》;20140521;第75-88页 * |
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CN105823815A (en) | 2016-08-03 |
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Inventor after: Shao Chenning Inventor after: Hui Guohua Inventor after: Zheng Haonan Inventor after: Zhou Zhixin Inventor after: Pan Fangqin Inventor after: Yang Xin Inventor after: Ye Wenjun Inventor after: Li Jian Inventor after: Gao Yuanyuan Inventor after: Zhang Jianfeng Inventor before: Li Jian Inventor before: Zhang Jianfeng Inventor before: Gao Yuanyuan |