CN105878943A - Traditional Chinese medicine preparation for treating uterine myoma - Google Patents

Traditional Chinese medicine preparation for treating uterine myoma Download PDF

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CN105878943A
CN105878943A CN201610470878.0A CN201610470878A CN105878943A CN 105878943 A CN105878943 A CN 105878943A CN 201610470878 A CN201610470878 A CN 201610470878A CN 105878943 A CN105878943 A CN 105878943A
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parts
root
medicine preparation
chinese medicine
chinese
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张莉
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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Abstract

The invention relates to a traditional Chinese medicine preparation for treating uterine myoma. The traditional Chinese medicine preparation is composed of, by weight, 140-160 parts of chestnut leaf, 110-130 parts of Codonopsis lanceolata, 70-90 parts of litchi shell, 50-70 parts of Herba corydalis saxicolae, 50-70 parts of Endothelium corneum gigeriae galli, 40-60 parts of Rhizoma cyperi, 50-70 parts of spina gleditisiae, 50-70 parts of Ramulus euonymi, 40-60 parts of Herba selaginellae doedereinii, 40-60 parts of Panax japonicus, 30-50 parts of sea buckthorn, 50-70 parts of lumbricus, 30-50 parts of Radix curcuma, 50-70 parts of Desmodium multiflorum, 40-60 parts of Cortex cinnamomi, 50-70 parts of Rhizoma dioscoreae, 70-90 parts of Marsdenia tinctoria, 40-60 parts of Radix lithospermi, 30-50 parts of oyster, 40-60 parts of hawthorn, 70-90 parts of Radix bupleuri, 70-90 parts of Radix trichosanthis, 30-50 parts of Radix polygoni multiflori, 20-40 parts of Rhizoma cimicifugae, 30-50 parts of Trogopterus dung and 20-40 parts of Rhizoma paridis. The traditional Chinese medicine preparation has efficacy of activating blood to disperse stasis, promoting qi to stop pain, softening hard mass to disperse stasis and detoxifying to subside swelling.

Description

A kind of Chinese medicine preparation treating fibroid
Technical field
The present invention relates to a kind of Chinese medicine preparation treating fibroid, belong to the field of Chinese medicines.
Background technology
Fibroid is the one formed with the doping of a small amount of fibrous connective tissue by the Uterine Smooth Cell of hyperplasia Substantive benign tumour, is one of modal disease in female reproductive system benign tumour.30～in 50 years old Year women's incidence of disease is up to more than 20%.Up-to-date epidemiologic data shows, the development of fibroid is in recent years In rising trend, and age of onset tends to rejuvenation.Its clinical common sympton is uterine hemorrhage, lower abdominal lump, Pressure symptom, pain, infertile.Its pathogenesis of doctor trained in Western medicine is thought: estrogen (Es), progestational hormone (P), grow because of Son (GF) can promote the growth of myomata；Gonadotropin-releasing hormone (GRH) is myomata growth control agent；Apoptosis is different Often especially Apoptosis extra-inhibitory is also relevant with the generation development of myomata.
Fibroid belongs to the traditional Chinese medical science " stone lump in the abdomen ", " lump in the abdomen is amassed " category.As " Jing Yue's complete work married woman rule " are said: " the stasis of blood Blood is detained and is made hemostasis, and only married woman has it.It was demonstrate,proved then or by menstrual period, or by postpartum, all internal injuries raw food, or be subject to outward Chill, or raged impairing liver, the circulation of vital energy in the wrong direction and blood stays；Or melancholy,anxiety and spleen, the deficiency of vital energy and stasis；Or it is long-pending weak to be overworked for a very long period, gas weak and Not all right, when always being transported by blood, remaining blood is not clean, and one is the most inverse, then amass day of being detained, and gradually to become lump in the abdomen.” Outer heresy, liver depression, the deficiency of vital energy, eventually because affecting blood, make hemostasis be detained, then scar gradually becomes.This disease is function Imbalance, the stagnation of the circulation of vital energy, blood stasis, cold solidifying, phlegm resistance, damp and hot, the deficiency of vital energy, positive unsaturated vapor caused, as: Wang Qingren Errors in Medicine Corrected cloud: " caking person, blood that must be tangible is also.Blood catches cold, and condenses into block, and blood is heated, and decocts It is boiled into block." and the uterus of women is extraordinary Fu-organ, is storage and discharge menses, breeds and the device of fetus of giving birth to Official, and source three discrimination, convergence is rushed, appoints, is superintended and directed three arteries and veins, close with whole body qi-blood relationship, so vessels of the uterus and collaterals of the uterus Qi and blood easily run and be obstructed and send out as fibroid.This disease principle of reatment abides by "Nei Jing" " Hard masses must be disintegrated, visitor more Person removes it, and Enlarged nodes must be resolved, retention requiring purgtion " and " tonification and purgation in combination ".That is: solid Tibetan is amassed, it should tapping； External perverse trend, it should dispel；The card that knot is poly-, it should dissipate；Be detained in internal disease and evil, answer medication attack by； Attack evil and help should double execute, make perverse trend go and healthy tendency is not hindered.
Doctor trained in Western medicine mainly uses operative treatment and hormone medicine (Ru486, GnRHa, danazol etc.) treatment, Such medicine not only affects fertility, and side effect is relatively big, and patient is difficult to accept.But Chinese medicine uterus Myomata effect is notable, and side effect is little, can exempt corrective surgery misery aspect, have big advantage.
Summary of the invention
Present invention aim at providing a kind of Chinese medicine preparation treating fibroid, this Chinese medicine preparation has curative effect and shows Writing, toxic and side effect is little, the advantage of clinical practice safety.
We's prolonged application clinically treatment fibroid, obtains good curative effect.Selection Li Ye in side, four Ye Can, can removing toxicity for detumescence；Again select semen litchi can promoting the circulation of qi dissipating bind, cold-dispelling pain-relieving；Meadowrueleaf corydalis root, clearing heat and detoxicating, Dampness removing, pain relieving；The membrane of a chicken's gizzard, stomach strengthening and digestion promoting；Rhizoma cyperi, promoting qi circulation and removing obstruction in the collateral, menstruction regulating and pain relieving；Spina gleditsiae, detumescence support Poison；Ramulus euonymi, broken blood stimulates the menstrual flow, removing toxicity for detumescence；Selaginella doederlleini, clearing heat and detoxicating, anticancer；Panax japonicus, qi-restoratives is strong Strong, dissipate stasis of blood hemostasis, swelling and pain relieving；Sea-buckthorn, promoting blood circulation to remove blood stasis；Earthworm, heat-clearing arresting convulsion, dredging collateral；Turmeric, broken Blood gas, inducing meastruation to relieve menalgia；Starve leech, promoting blood circulation and stopping pain, removing toxicity for detumescence；Chinese cassia tree, complement sun, warming spleen and stomach is logical Blood vessels.Chicken scarlet bloodlily, promoting blood circulation for regulating menstruation, blood stasis removing analgesic；Caulis Marsdeniae tinctoriae, soothing liver and harmonizing stomach；Asian puccoon, cooling and activating blood, male Oyster softening and resolving hard mass, hawthorn energy promoting the circulation of qi can dissipate the stasis of blood；Radix bupleuri, soothing liver-qi stagnation；Root of Chinese trichosanthes, detumescence and apocenosis；The fleece-flower root Removing toxic substances, disappear carbuncle；Rattletop is clearing heat and detoxicating；Excrementum pteropi, promoting blood circulation to remove blood stasis；Paris polyphylla, swelling and pain relieving；All medicines share, Full side is made to play promoting blood circulation and removing blood stasis, effect of promoting qi circulation and relieving pain, softening and resolving hard mass, removing toxicity for detumescence altogether.
The amounts of components of Chinese medicine preparation of the present invention is groped in a large number to sum up through inventor and is drawn, each group Demultiplexing amount has preferable curative effect in following weight parts scope.
Chinese medicine preparation of the present invention is made up of the raw material of following weight proportion: Li Ye 140～160 parts, lance asiabell root 110～130 parts, semen litchi 70～90 parts, meadowrueleaf corydalis root 50～70 parts, the membrane of a chicken's gizzard 50～70 parts, rhizoma cyperi 40～ 60 parts, spina gleditsiae 50～70 parts, Ramulus euonymi 50～70 parts, selaginella doederlleini 40～60 parts, panax japonicus 40～60 Part, sea-buckthorn 30～50 parts, earthworm 50～70 parts, turmeric 30～50 parts, hungry leech 50～70 parts, Chinese cassia tree 40～60 parts, chicken scarlet bloodlily 50～70 parts, Caulis Marsdeniae tinctoriae 70～90 parts, Asian puccoon 40～60 parts, oyster 30～50 Part, hawthorn 40～60 parts, radix bupleuri 70～90 parts, root of Chinese trichosanthes 70～90 parts, the fleece-flower root 30～50 parts, liter Fiber crops 20～40 parts, excrementum pteropi 30～50 parts, Paris polyphylla 20～40 parts.
Preferred as Chinese medicine preparation of the present invention, it is made up of the raw material of following weight proportion: Li Ye 150 Part, lance asiabell root 120 parts, semen litchi 80 parts, meadowrueleaf corydalis root 60 parts, the membrane of a chicken's gizzard 60 parts, rhizoma cyperi 50 parts, soap Angle thorn 60 parts, Ramulus euonymi 60 parts, selaginella doederlleini 50 parts, panax japonicus 50 parts, sea-buckthorn 40 parts, earthworm 60 Part, 40 parts of turmeric, hungry leech 60 parts, Chinese cassia tree 50 parts, chicken scarlet bloodlily 60 parts, Caulis Marsdeniae tinctoriae 80 parts, Asian puccoon 50 parts, oyster 40 parts, hawthorn 50 parts, radix bupleuri 80 parts, root of Chinese trichosanthes 80 parts, the fleece-flower root 40 parts, rattletop 30 parts, excrementum pteropi 40 parts, Paris polyphylla 30 parts.
Preferably, Chinese medicine preparation of the present invention, it is made up of the raw material of following weight proportion: Li Ye 140 parts, Lance asiabell root 110 parts, semen litchi 90 parts, meadowrueleaf corydalis root 70 parts, the membrane of a chicken's gizzard 50 parts, rhizoma cyperi 60 parts, spina gleditsiae 70 parts, Ramulus euonymi 70 parts, selaginella doederlleini 40 parts, panax japonicus 60 parts, sea-buckthorn 30 parts, earthworm 70 parts, ginger Yellow 30 parts, starve leech 70 parts, Chinese cassia tree 40 parts, chicken scarlet bloodlily 70 parts, Caulis Marsdeniae tinctoriae 90 parts, Asian puccoon 40 parts, Oyster 50 parts, hawthorn 40 parts, radix bupleuri 90 parts, root of Chinese trichosanthes 70 parts, the fleece-flower root 30 parts, rattletop 40 parts, Excrementum pteropi 50 parts, Paris polyphylla 40 parts.
Preferably, Chinese medicine preparation of the present invention, it is made up of the raw material of following weight proportion: Li Ye 160 parts, Lance asiabell root 130 parts, semen litchi 70 parts, meadowrueleaf corydalis root 50 parts, the membrane of a chicken's gizzard 70 parts, rhizoma cyperi 40 parts, spina gleditsiae 50 parts, Ramulus euonymi 50 parts, selaginella doederlleini 60 parts, panax japonicus 40 parts, sea-buckthorn 50 parts, earthworm 50 parts, ginger Yellow 50 parts, starve leech 50 parts, Chinese cassia tree 60 parts, chicken scarlet bloodlily 50 parts, Caulis Marsdeniae tinctoriae 70 parts, Asian puccoon 60 parts, Oyster 30 parts, hawthorn 60 parts, radix bupleuri 70 parts, root of Chinese trichosanthes 90 parts, the fleece-flower root 50 parts, rattletop 20 parts, Excrementum pteropi 30 parts, Paris polyphylla 20 parts.
It is tablet, dispersion that Chinese medicine preparation of the present invention add pharmaceutic adjuvant conventional in pharmacy to be made oral formulations Sheet, capsule, pill, granule.
Tablet: by gained Traditional Chinese drug mixture, with appropriate amount of starch, hydroxypropyl cellulose, mixing, pelletize, compacting Piece agent.
Dispersible tablet: by gained Traditional Chinese drug mixture, adds appropriate microcrystalline cellulose, mixing, pelletizes, and suppresses composition Discrete piece agent.
The auxiliary materials such as capsule: by gained Traditional Chinese drug mixture, adds suitable lactose, starch, pelletize, encapsulated, Make hard capsule.
Pill: by gained Traditional Chinese drug mixture, adds stearic acid, polyethylene glycols auxiliary material, drips and make pill.
Granule: by gained Traditional Chinese drug mixture, with appropriate dextrin, sucrose, mixing, pelletize, be dried, system Become granule.
The oral formulations that Chinese medicine preparation of the present invention is made is preferably capsule.
The preparation method of Chinese medicine preparation of the present invention is: take above-mentioned dosage ratio Li Ye, lance asiabell root, semen litchi, rock The coptis, the membrane of a chicken's gizzard, rhizoma cyperi, spina gleditsiae, Ramulus euonymi, selaginella doederlleini, panax japonicus, sea-buckthorn, earthworm, turmeric, Starve leech, Chinese cassia tree, chicken scarlet bloodlily, Caulis Marsdeniae tinctoriae, Asian puccoon, oyster, hawthorn, radix bupleuri, root of Chinese trichosanthes, the fleece-flower root, Rattletop, excrementum pteropi, Paris polyphylla medicinal material, clean, go the removal of impurity, uses constant temperature oven to dry above-mentioned medicinal material Process, dry temperature be 60～80 DEG C, drying time be 1～3h；Medicinal material after drying is pulverized, powder Broken mesh number is 80～120 mesh, mixes, and obtains Traditional Chinese drug mixture, and after carrying out sterilizing, dispenses, ?.
Preferably, the preparation method of Chinese medicine preparation of the present invention is: take above-mentioned dosage ratio Li Ye, lance asiabell root, litchi Branch core, meadowrueleaf corydalis root, the membrane of a chicken's gizzard, rhizoma cyperi, spina gleditsiae, Ramulus euonymi, selaginella doederlleini, panax japonicus, sea-buckthorn, earthworm, Turmeric, starve leech, Chinese cassia tree, chicken scarlet bloodlily, Caulis Marsdeniae tinctoriae, Asian puccoon, oyster, hawthorn, radix bupleuri, root of Chinese trichosanthes, what The tuber of multiflower knotweed, rattletop, excrementum pteropi, Paris polyphylla medicinal material, clean, go the removal of impurity, uses constant temperature to dry above-mentioned medicinal material Case drying and processing, dry temperature be 70 DEG C, drying time be 2h；Medicinal material after drying is pulverized, powder Broken mesh number is 100 mesh, mixes, and obtains Traditional Chinese drug mixture, and after carrying out sterilizing, dispenses,.
The beneficial effect of Chinese medicine preparation of the present invention:
The present invention is under Chinese Traditional Medicine theory and clinical empirical summary instruct, and through dialectical compatibility, chooses Each bulk drug component and proportioning thereof.These drug regimens make each efficacy of drugs produce the effect of Synergistic, make Obtain side entirely and there is promoting blood circulation and removing blood stasis, effect of promoting qi circulation and relieving pain, softening and resolving hard mass, removing toxicity for detumescence.It is thus possible to effectively control Treat fibroid, and improve the clinical efficacy of full side.And the preparation technology of Chinese medicine preparation of the present invention is simple, Science is feasible, low cost, has good market application foreground.
Pharmacological experiment confirms: Chinese medicine preparation of the present invention has obvious analgesia, anti-inflammatory and suppresses big rat meat The effect of bud hyperblastosis.According to clinical verification, the total effective rate 92.8% of the clinical cure of Chinese medicine preparation of the present invention, The volume of knurl body can be obviously reduced, improve the clinical symptoms of patient.
Detailed description of the invention
The following is the specific embodiment of present invention, be used for illustrating technical problem to be solved in present specification Technical scheme, contribute to skilled artisan understands that present invention, but the realization of technical solution of the present invention It is not limited to these embodiments.
The preparation of embodiment 1 Traditional Chinese medicine preparation capsule of the present invention agent
Take Li Ye 150g, lance asiabell root 120g, semen litchi 80g, meadowrueleaf corydalis root 60g, the membrane of a chicken's gizzard 60g, rhizoma cyperi 50g, Spina gleditsiae 60g, Ramulus euonymi 60g, selaginella doederlleini 50g, panax japonicus 50g, sea-buckthorn 40g, earthworm 60g, turmeric 40g, hungry leech 60g, Chinese cassia tree 50g, chicken scarlet bloodlily 60g, Caulis Marsdeniae tinctoriae 80g, Asian puccoon 50g, oyster 40g, mountain Short, bristly hair or beard 50g, radix bupleuri 80g, root of Chinese trichosanthes 80g, fleece-flower root 40g, rattletop 30g, excrementum pteropi 40g, Paris polyphylla 30g； Clean, go the removal of impurity, above-mentioned medicinal material is used constant temperature oven drying and processing, dry temperature be 70 DEG C, Drying time is 2h；Medicinal material after drying is pulverized, and pulverizing mesh number is 100 mesh, mixes, To Traditional Chinese drug mixture, and after carrying out sterilizing, add suitable lactose, the auxiliary material such as starch, pelletize, dress up 1000 Seed lac capsule.
The preparation of embodiment 2 Chinese medicine preparation of the present invention Disket
Take Li Ye 140g, lance asiabell root 110g, semen litchi 90g, meadowrueleaf corydalis root 70g, the membrane of a chicken's gizzard 50g, rhizoma cyperi 60g, Spina gleditsiae 70g, Ramulus euonymi 70g, selaginella doederlleini 40g, panax japonicus 60g, sea-buckthorn 30g, earthworm 70g, turmeric 30g, hungry leech 70g, Chinese cassia tree 40g, chicken scarlet bloodlily 70g, Caulis Marsdeniae tinctoriae 90g, Asian puccoon 40g, oyster 50g, mountain Short, bristly hair or beard 40g, radix bupleuri 90g, root of Chinese trichosanthes 70g, fleece-flower root 30g, rattletop 40g, excrementum pteropi 50g, Paris polyphylla 40g； Above-mentioned medicinal material is used constant temperature oven drying and processing, dry temperature be 60 DEG C, drying time be 3h；To dry After medicinal material pulverize, pulverize mesh number be 120 mesh, mix, obtain Traditional Chinese drug mixture, and go out After bacterium, add appropriate microcrystalline cellulose, mixing, pelletize, be pressed into 1000 dispersible tablets.
The preparation of the tablet of embodiment 3 Chinese medicine preparation of the present invention
Take Li Ye 160g, lance asiabell root 130g, semen litchi 70g, meadowrueleaf corydalis root 50g, the membrane of a chicken's gizzard 70g, rhizoma cyperi 40g, Spina gleditsiae 50g, Ramulus euonymi 50g, selaginella doederlleini 60g, panax japonicus 40g, sea-buckthorn 50g, earthworm 50g, turmeric 50g, hungry leech 50g, Chinese cassia tree 60g, chicken scarlet bloodlily 50g, Caulis Marsdeniae tinctoriae 70g, Asian puccoon 60g, oyster 30g, mountain Short, bristly hair or beard 60g, radix bupleuri 70g, root of Chinese trichosanthes 90g, fleece-flower root 50g, rattletop 20g, excrementum pteropi 30g, Paris polyphylla 20g； Above-mentioned medicinal material is used constant temperature oven drying and processing, dry temperature be 80 DEG C, drying time be 1h；To dry After medicinal material pulverize, pulverize mesh number be 80 mesh, mix, obtain Traditional Chinese drug mixture, and go out After bacterium, with appropriate amount of starch, hydroxypropyl cellulose, mixing, pelletize, be pressed into 1000 tablets.
The preparation of the pill of embodiment 4 Chinese medicine preparation of the present invention
Take Li Ye 140g, lance asiabell root 110g, semen litchi 80g, meadowrueleaf corydalis root 60g, the membrane of a chicken's gizzard 60g, rhizoma cyperi 50g, Spina gleditsiae 60g, Ramulus euonymi 60g, selaginella doederlleini 50g, panax japonicus 40g, sea-buckthorn 50g, earthworm 60g, turmeric 40g, hungry leech 60g, Chinese cassia tree 60g, chicken scarlet bloodlily 50g, Caulis Marsdeniae tinctoriae 80g, Asian puccoon 40g, oyster 50g, mountain Short, bristly hair or beard 50g, radix bupleuri 70g, root of Chinese trichosanthes 80g, fleece-flower root 30g, rattletop 30g, excrementum pteropi 40g, Paris polyphylla 30g； Above-mentioned medicinal material is used constant temperature oven drying and processing, dry temperature be 75 DEG C, drying time be 1h；To dry After medicinal material pulverize, pulverize mesh number be 80 mesh, mix, obtain Traditional Chinese drug mixture, and go out After bacterium, add stearic acid, polyethylene glycols auxiliary material, drip and make 1000 pills.
The preparation of the granule of embodiment 5 Chinese medicine preparation of the present invention
Take Li Ye 150g, lance asiabell root 120g, semen litchi 90g, meadowrueleaf corydalis root 50g, the membrane of a chicken's gizzard 70g, rhizoma cyperi 40g, Spina gleditsiae 60g, Ramulus euonymi 60g, selaginella doederlleini 40g, panax japonicus 50g, sea-buckthorn 40g, earthworm 50g, turmeric 40g, hungry leech 60g, Chinese cassia tree 40g, chicken scarlet bloodlily 60g, Caulis Marsdeniae tinctoriae 90g, Asian puccoon 40g, oyster 40g, mountain Short, bristly hair or beard 60g, radix bupleuri 80g, root of Chinese trichosanthes 70g, fleece-flower root 40g, rattletop 20g, excrementum pteropi 30g, Paris polyphylla 30g； Above-mentioned medicinal material is used constant temperature oven drying and processing, dry temperature be 65 DEG C, drying time be 3h；To dry After medicinal material pulverize, pulverize mesh number be 100 mesh, mix, obtain Traditional Chinese drug mixture, and go out After bacterium, with appropriate dextrin, sucrose, mixing, pelletize, be dried, make 1000g granule.
The beneficial effect of of the present invention Chinese medicine preparation is expanded on further, these test example bags below by way of test example Include pharmacodynamics test and the clinical observation on the therapeutic effect test of Chinese medicine preparation of the present invention.
The pharmacodynamics test of test example 1 Chinese medicine preparation of the present invention
1. test material
1.1 trial drug
Xiaojie'an capsule (Yunnan Liangfang Pharmaceutical Co., Ltd)；Make according to " present invention implements 1 preparation method " Become the present invention to implement the medicine of 1 group, make the present invention according to the preparation method of 2 " present invention implement " and implement 2 The medicine of group, makes the present invention according to the preparation method of 3 " present invention implement " and implements the medicine of 3 groups, each group Medicine adds the carboxymethylcellulose sodium solution of 0.5% and is configured to the use of suspension liquid.
1.2 experimental animal
Kunming kind female mice 20～22g, wistar female rats 150～200g, Xi'an Medical University's experiment is dynamic Thing center provides.
2. test method and result
The analgesic activity of 2.1 pairs of mouse
Taking the mouse 50 of health, be randomly divided into 5 groups, respectively physiological saline, positive control drug group (disappears Knot peace capsule), the embodiment of the present invention 1 group, the embodiment of the present invention 2 groups, the embodiment of the present invention 3 groups, often group 10, gastric infusion, after being administered 30min, each group mouse equal lumbar injection 0.5% acetic acid 0.2ml/ only, and remembers In record l0min, writhing response number of animals occurs.
The table 1 analgesic activity to mouse
Note: compare with physiological saline,△P ＜ 0.05,△△P ＜ 0.01.
Shown by table 1 result, compare with physiological saline, the embodiment of the present invention 1 group, 2 groups, the writhing of 3 groups anti- Should rate be 25%, 40%, 30%, and have notable significant difference.This explanation, Chinese medicine preparation of the present invention has Significantly analgesic activity.
2.2 impacts on mouse pedal swelling
Taking the mouse 50 of health, be randomly divided into 5 groups, respectively physiological saline, positive control drug group (disappears Knot peace capsule), the embodiment of the present invention 1 group, the embodiment of the present invention 2 groups, the embodiment of the present invention 3 groups, often group 10, each group of two foot sole of the foot fixed positions measurement girths twice about mouse, take average as girth normal value. Inflammation is caused at left and right foot plantar subcutaneous injection 1% antler glue 0.02ml.Cause gastric infusion after inflammation, then different Two foot sole of the foot fixed position girth about time measurement, before and after calculating cause inflammation, girth difference is swelling.
The table 2 impact on mouse foot swelling
Note: compare with physiological saline,△P ＜ 0.05,△△P ＜ 0.01.
As shown in Table 2, embodiments of the invention 1 group, 2 groups, the mouse foot sole of the foot is swollen by the medicine of 3 groups Expansibility has suppression in various degree.This explanation, Chinese medicine preparation of the present invention has good antiinflammatory action.
2.3 impacts that rat granuloma is swollen
Take wistar rat and be randomly divided into 5 groups, respectively physiological saline, positive control drug group (Xiaojie'an capsule), The embodiment of the present invention 1 group, the embodiment of the present invention 2 groups, the embodiment of the present invention 3 groups, often group 10, male and female Half and half, normal group routine is raised, and model group rats is anesthetized with ether, and cuts osculum at back, will with ophthalmic tweezers The sterilizing cotton balls of the 20mg being weighed is implanted subcutaneous from little otch, skin suture immediately, and other respectively organize same Modeling, starts to be administered performing the operation next day, after continuous 7 days are administered, put to death rat, opens former otch, by cotton balls Take out together with surrounding connective tissue, reject adipose tissue, put into 50 DEG C of drying in baking oven, claim dry weight, deduct Cotton balls original weight amount i.e. obtains granulomatous weight.
The impact that rat granuloma is swollen by table 3
Note: compare with physiological saline,△P ＜ 0.05,△△P ＜ 0.01.
As shown in Table 3, compare with physiological saline, embodiments of the invention 1 group, 2 groups, 3 groups Medicine has significantly suppression (P ＜ 0.05 or P ＜ 0.01) to rat granuloma is swollen.This also discloses, the present invention Chinese medicine preparation has the effect substantially suppressing rat granulation tissue hyperplasia.
In order to verify the curative effect of Chinese medicine preparation of the present invention further, we are by preparation in above-mentioned specific embodiment 1 Finished capsule product agent medicine has carried out corresponding clinical testing, now result is reported as follows.
Test example 2 clinical observation and curative effect
2.1 physical data
Accept the patient of fibroid for medical treatment and all meet fibroid diagnostic criteria in " gynecotokology ", altogether 132 Example, is randomly divided into two groups, treatment group 69 example, age 33～65 years old, year mean age (42.53 ± 3.49), Average course of disease (2.35 ± 0.62) year；Myomata diameter minimum 1.1cm, is 5.6cm, average 3.19 ± 0.49cm to the maximum. Control group 63 example, age 32～67 years old, year mean age (41.94 ± 4.40), average course of disease (2.66 ± 0.75) Year；Control group 63 example, myomata diameter minimum 1.0cm, it is 5.3cm, average 3.27 ± 0.65cm to the maximum.Two The group aspect such as patient age, the course of disease, myomata size, through statistical procedures difference, not statistically significant (P ＞ 0.05), There is comparativity.
2.2 diagnosis and inclusion criterias
Formulate with reference to relevant content in fibroid diagnostic criteria in " gynecotokology ".Enter to organize case and meet following Condition: 1. patient can be asymptomatic, or paramenia, mainly shows as menorrhagia, and menostaxis, menstruation week Phase shortens, and can accompany leucorrhea increasing, hypogastralgia, the soreness of waist, lower abdomen falling inflation, SA etc..Tongue is dark violet to be had Ecchymosis, small and wiry pulse or the most puckery.2. gynecologial examination: uterus irregularly increases as within pregnant 2 first quarter moon sizes, matter Firmly, there is spherical or nodositas projection on surface, smooth, without being adhered.B ultrasonic is diagnosed as single-shot or multiple uterus muscle Knurl, single myomata diameter is less than 5.3. laboratory examination: routine test hemoglobin and hepatic and renal function.Nothing The heart, brain, liver, the important organ disease of kidney, and it is sick to be required to non-operative treatment, be ready partner treatment person.
2.3 methods for the treatment of
Control group: give Xiaojie'an capsule (Yunnan Liangfang Pharmaceutical Co., Ltd) oral medication, 2 tablets/time, 3 Secondary/d, the menstrual period withdraws.Within 2 months, it is a course for the treatment of, after serveing on 3 courses for the treatment of, checks B ultrasonic.
Treatment group: the capsule 2 tablets/time of the oral embodiment of the present invention 1 preparation, 3 times/d, the menstrual period withdraws. Within 2 months, it is a course for the treatment of, after serveing on 3 courses for the treatment of, checks B ultrasonic.
Observation index: the change of menstruation, including through situations such as amount and menstruation recoveries.Fibroid Volume Changes. Before treatment and treat after rear 3 courses for the treatment of, equal B ultrasonic monitoring fibroid number and the three-dimensional warp of myomata volume, I.e. length, width and height calculate the volume of fibroid.Patient to multiple myomata, fibroid total volume is Each myomata volume sum.Laboratory examination: monitor hemoglobin and the index etc. of hepatic and renal function before and after treatment.
2.4 efficacy assessment standard
Judge curative effect according to " new Chinese medicine guideline of clinical investigations ", cure: B ultrasonic shows that fibroid disappears, Clinical symptom disappearance；Effective: B ultrasonic shows that fibroid reduces more than 1.5cm, clinical symptom relief or disappearance； Effective: B ultrasonic shows that fibroid reduces 0.5～1.5cm, clinical symptoms are without improving, or fibroid is unchanged, Clinical symptom disappearance；Invalid: myomata is unchanged or increases, clinical symptoms are without improving.
2.5 treatment results
2.5.1 result of the test is shown in Table 4.
4 liang of table group patient clinical comparitive study
Note: compare with control group,△P ＜ 0.05,△△P ＜ 0.01.
Clinical study results is shown in Table 4 and understands, and after the treatment of 3 courses for the treatment of, patient menstrual is uncomfortable, waist abdomen pain The clinical symptoms such as pain have significantly improvement.Treatment group total effective rate is 92.8%, and control group (disappears and ties peace glue Capsule) patient's total effective rate be 69.8%.Result shows, the Chinese medicine preparation of the present invention is in treatment fibroid disease Clinical efficacy in terms of Bing is notable, hence it is evident that be better than control group.
5 liang of table group patient uterine myomata volume ratio relatively mm3(x±s)
Note: compare before and after treating with this group,▲P ＜ 0.05,▲▲P ＜ 0.01, compares with control group,△P ＜ 0.05,△△P ＜ 0.01.
From the experimental result of table 5, after 3 courses for the treatment of of two groups of patient therapy, compared with before treatment, 2 groups The myomata volume of patient uterine has and significantly reduces, and has significant statistical significance (P ＜ 0.01).With right Comparing according to group, the result for the treatment of of Chinese medicine preparation of the present invention is more excellent (P ＜ 0.05).
2.5.2 bad reaction trace analysis
The 132 example patients accepted for medical treatment are carried out observation of curative effect, except control group has 2 examples to occur having a stomach upset, continues to control Alleviate after treating 1 week.And in the clinical observation for the treatment of group 69 example patient of the present invention, do not find any bad instead Answer and toxicity.
In sum, the Chinese medicine preparation of the present invention, in terms for the treatment of fibroid disease, can be obviously reduced knurl body Volume, improve the clinical symptoms of patient.This further illustrates, the Chinese medicine preparation of the present invention has significantly Clinical efficacy and the little feature of toxic and side effect, clinic popularization and application.

Claims (8)

1. the Chinese medicine preparation treating fibroid, it is characterised in that it is made up of the raw material of following weight proportion: Li Ye 140～160 parts, lance asiabell root 110～130 parts, semen litchi 70～90 parts, meadowrueleaf corydalis root 50～70 parts, the membrane of a chicken's gizzard 50～70 parts, Rhizoma cyperi 40～60 parts, spina gleditsiae 50～70 parts, Ramulus euonymi 50～70 parts, selaginella doederlleini 40～60 parts, panax japonicus 40～60 parts, Sea-buckthorn 30～50 parts, earthworm 50～70 parts, turmeric 30～50 parts, hungry leech 50～70 parts, Chinese cassia tree 40～60 parts, chicken blood Lotus 50～70 parts, Caulis Marsdeniae tinctoriae 70～90 parts, Asian puccoon 40～60 parts, oyster 30～50 parts, hawthorn 40～60 parts, radix bupleuri 70～90 parts, root of Chinese trichosanthes 70～90 parts, the fleece-flower root 30～50 parts, rattletop 20～40 parts, excrementum pteropi 30～50 parts, Paris polyphylla 20～40 parts.
2. treat as claimed in claim 1 the Chinese medicine preparation of fibroid, it is characterised in that it is former by following weight proportion Material composition: Li Ye 150 parts, lance asiabell root 120 parts, semen litchi 80 parts, meadowrueleaf corydalis root 60 parts, the membrane of a chicken's gizzard 60 parts, rhizoma cyperi 50 Part, spina gleditsiae 60 parts, Ramulus euonymi 60 parts, selaginella doederlleini 50 parts, panax japonicus 50 parts, sea-buckthorn 40 parts, earthworm 60 parts, ginger Yellow 40 parts, starve leech 60 parts, Chinese cassia tree 50 parts, chicken scarlet bloodlily 60 parts, Caulis Marsdeniae tinctoriae 80 parts, Asian puccoon 50 parts, oyster 40 parts, Hawthorn 50 parts, radix bupleuri 80 parts, root of Chinese trichosanthes 80 parts, the fleece-flower root 40 parts, rattletop 30 parts, excrementum pteropi 40 parts, Paris polyphylla 30 parts.
3. treat as claimed in claim 1 the Chinese medicine preparation of fibroid, it is characterised in that it is former by following weight proportion Material composition: Li Ye 140 parts, lance asiabell root 110 parts, semen litchi 90 parts, meadowrueleaf corydalis root 70 parts, the membrane of a chicken's gizzard 50 parts, rhizoma cyperi 60 Part, spina gleditsiae 70 parts, Ramulus euonymi 70 parts, selaginella doederlleini 40 parts, panax japonicus 60 parts, sea-buckthorn 30 parts, earthworm 70 parts, ginger Yellow 30 parts, starve leech 70 parts, Chinese cassia tree 40 parts, chicken scarlet bloodlily 70 parts, Caulis Marsdeniae tinctoriae 90 parts, Asian puccoon 40 parts, oyster 50 parts, Hawthorn 40 parts, radix bupleuri 90 parts, root of Chinese trichosanthes 70 parts, the fleece-flower root 30 parts, rattletop 40 parts, excrementum pteropi 50 parts, Paris polyphylla 40 parts.
4. treat as claimed in claim 1 the Chinese medicine preparation of fibroid, it is characterised in that it is former by following weight proportion Material composition: Li Ye 160 parts, lance asiabell root 130 parts, semen litchi 70 parts, meadowrueleaf corydalis root 50 parts, the membrane of a chicken's gizzard 70 parts, rhizoma cyperi 40 Part, spina gleditsiae 50 parts, Ramulus euonymi 50 parts, selaginella doederlleini 60 parts, panax japonicus 40 parts, sea-buckthorn 50 parts, earthworm 50 parts, ginger Yellow 50 parts, starve leech 50 parts, Chinese cassia tree 60 parts, chicken scarlet bloodlily 50 parts, Caulis Marsdeniae tinctoriae 70 parts, Asian puccoon 60 parts, oyster 30 parts, Hawthorn 60 parts, radix bupleuri 70 parts, root of Chinese trichosanthes 90 parts, the fleece-flower root 50 parts, rattletop 20 parts, excrementum pteropi 30 parts, Paris polyphylla 20 parts.
5. as described in Claims 1 to 4 is arbitrary, treat the Chinese medicine preparation of fibroid, it is characterised in that described Chinese medicine preparation adds It is tablet, dispersible tablet, capsule, pill, granule that pharmaceutic adjuvant conventional in pharmacy makes oral formulations.
6. treat the Chinese medicine preparation of fibroid as claimed in claim 5, it is characterised in that it is oral that described Chinese medicine preparation is made Preparation is preferably capsule.
7. as described in Claims 1 to 4 is arbitrary, treat the preparation method of the Chinese medicine preparation of fibroid, it is characterised in that in described The preparation method of medicine preparation is as follows:
Take above-mentioned dosage ratio Li Ye, lance asiabell root, semen litchi, meadowrueleaf corydalis root, the membrane of a chicken's gizzard, rhizoma cyperi, spina gleditsiae, Ramulus euonymi, stone Upper cypress, panax japonicus, sea-buckthorn, earthworm, turmeric, starve leech, Chinese cassia tree, chicken scarlet bloodlily, Caulis Marsdeniae tinctoriae, Asian puccoon, oyster, hawthorn, Radix bupleuri, root of Chinese trichosanthes, the fleece-flower root, rattletop, excrementum pteropi, Paris polyphylla medicinal material, clean, go the removal of impurity, is used by above-mentioned medicinal material Constant temperature oven drying and processing, dry temperature be 60～80 DEG C, drying time be 1～3h；Medicinal material after drying is pulverized, Pulverizing mesh number is 80～120 mesh, mixes, obtains Traditional Chinese drug mixture, and after carrying out sterilizing, dispenses,.
8. treat the preparation method of the Chinese medicine preparation of fibroid as claimed in claim 7, it is characterised in that described Chinese medicine preparation Preparation method as follows:
Take above-mentioned dosage ratio Li Ye, lance asiabell root, semen litchi, meadowrueleaf corydalis root, the membrane of a chicken's gizzard, rhizoma cyperi, spina gleditsiae, Ramulus euonymi, stone Upper cypress, panax japonicus, sea-buckthorn, earthworm, turmeric, starve leech, Chinese cassia tree, chicken scarlet bloodlily, Caulis Marsdeniae tinctoriae, Asian puccoon, oyster, hawthorn, Radix bupleuri, root of Chinese trichosanthes, the fleece-flower root, rattletop, excrementum pteropi, Paris polyphylla medicinal material, clean, go the removal of impurity, is used by above-mentioned medicinal material Constant temperature oven drying and processing, dry temperature be 70 DEG C, drying time be 2h；Medicinal material after drying is pulverized, and pulverizes mesh number It is 100 mesh, mixes, obtain Traditional Chinese drug mixture, and after carrying out sterilizing, dispense,.
CN201610470878.0A 2016-06-23 2016-06-23 Traditional Chinese medicine preparation for treating uterine myoma Withdrawn CN105878943A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104984020A (en) * 2015-07-30 2015-10-21 宁波好口味食品有限公司 Traditional Chinese medicinal preparation for treating hysteromyoma, and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104984020A (en) * 2015-07-30 2015-10-21 宁波好口味食品有限公司 Traditional Chinese medicinal preparation for treating hysteromyoma, and preparation method thereof

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Application publication date: 20160824