CN105878851A - Pharmaceutical composition for treating qi-blood deficiency syndrome and preparation method of pharmaceutical composition - Google Patents

Pharmaceutical composition for treating qi-blood deficiency syndrome and preparation method of pharmaceutical composition Download PDF

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CN105878851A
CN105878851A CN201610482244.7A CN201610482244A CN105878851A CN 105878851 A CN105878851 A CN 105878851A CN 201610482244 A CN201610482244 A CN 201610482244A CN 105878851 A CN105878851 A CN 105878851A
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pharmaceutical composition
blood
heated
maltose
weight
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CN105878851B (en
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谢若男
曹奕
杨满琴
高玉菊
张洵
徐玥玮
王丽
黄云
蔡明�
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ACUPUNCTURE HOSPITAL OF ANHUI UNIVERSITY OF TCM
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/52—Juglandaceae (Walnut family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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Abstract

The invention provides a pharmaceutical composition for treating a qi-blood deficiency syndrome and a preparation method of the pharmaceutical composition, and relates to the technical field of qi-blood deficiency syndrome treatment. The pharmaceutical composition is prepared from the following effective ingredients by weight: 95-105g of donkey-hide gelatin, 95-105g of astragalus membranaceus, 35-50g of wolfberry fruits, 35-60g of arillus longan, 95-105g of Chinese yam, 35-50g of walnut kernels, 30-45g of black sesame, 35-50g of parched hawthorn fruits, 35-50g of coloured malt, 25-40g of flower buds of Japanese apricot, 25-40g of pericarpium citri reticulatae and 290-305g of cerealose. The pharmaceutical composition is obtained according to the yin-yang and qi-blood deficiency and excess changes of the human heart, is refined and processed by the processes of soaking, decocting, concentrating, paste forming, and has the effect of strengthening the spleen and stomach during the nourishing process; the indigestion phenomenon caused by the greasy thick paste formula is avoided; the response of a patient is good; the curative effect is significant; meanwhile, the preparation technology is simple; and the pharmaceutical composition is free of other additives, free of pollution and environment-friendly.

Description

For pharmaceutical composition treating deficiency of both QI and blood and preparation method thereof
Technical field
The present invention relates to deficiency of both QI and blood treatment technology field, be specifically related to a kind of drug regimen for treating deficiency of both QI and blood Thing and preparation method thereof.
Background technology
Society, along with the raising of living standards of the people, health care consciousness is gradually strengthened, motherland's traditional medicine preventive treatment of disease, Prevention and treatment of chronic diseases field, ensure and promote people's health aspect and play positive effect.The traditional Chinese medical science thinks that " in healthy energy is deposited, heresy is not Can do ", under the guidance of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs Therapeutic Principle, by the medical treatment of cream side, body can be made to increase healthy energy, improve resistance against diseases, Check exopathogen invasion and attack, make the deficient state of internal organs be corrected；Making equilibrium between yin and yang, QI and blood and tune, body function is gradually recovered, i.e. " YIN and YANG in a relative equilibrium, life activities being normally maintained ", thus reach to keep fit, prolong life, diseases prevention, cure the disease, improve the purpose of Abwehrkraft des Koepers.Simultaneously Good in taste due to cream side, taking convenience, the compliance of patient is also greatly improved the most over the course for the treatment of.
Summary of the invention
In order to solve above-mentioned technical problem, it is an object of the invention to provide a kind of more notable for deficiency of both QI and blood curative effect, and Vigorate qi and replenish the blood, tranquilizing by nourishing the heart, the pharmaceutical composition of invigorating the spleen and regulating the stomach.
To achieve these goals, the technical solution adopted in the present invention is as follows:
A kind of pharmaceutical composition for treating deficiency of both QI and blood, its effective ingredient is prepared by the raw material of Chinese medicine of following weight:
More preferably, for treating the pharmaceutical composition of deficiency of both QI and blood, its effective ingredient is prepared by the raw material of Chinese medicine of following weight:
Most preferably, for treating the pharmaceutical composition of deficiency of both QI and blood, its effective ingredient is prepared by the raw material of Chinese medicine of following weight:
Colla Corii Asini nature and flavor are sweet flat, and tonifying blood and arresting bleeding is nourshing Yin and drynsessmoistening prescription；The Radix Astragali is sweet in flavor and warm in property, strengthening spleen and middle warmer, and benefit defends consolidating superficial resistance, and both share, Can QI invigorating, can nourish blood again, be monarch drug altogether.Arillus Longan reinforcing the heart spleen, replenishing QI and blood, tranquilizing the mind in side；Rhizoma Dioscoreae supplementing QI and nourishing YIN, Spleen reinforcing lung kidney；Fructus Lycii nourishing the liver and kidney, benefiting essence-blood, improving eyesight；Semen Juglandis the kidney invigorating lung moistening, loosening bowel to relieve constipation；Semen Sesami Nigrum invigorating the liver and kidney, Benefiting essence-blood, intestine moistening are dry；Five share altogether for ministerial drug, play the effect of foster essence and blood, invigorating the liver and kidney.Hawthorn digestingization is amassed, and Fructus Hordei Germinatus is good for Diabetes involving middle-JIAO is eaten, flower bud of Japanese apricot depressed liver-energy dispersing and QI regulating, stomach function regulating, Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, and it is adjuvant drug altogether that four medicines share, and joins with many tonic essence and blood medicines 5, be allowed to mend and oiliness, mend and the most stagnant.Maltose is sweet, has the merit adjusting benefit, the property of neutralization, and other drug in the side of correct for Bad mouthfeel, make cream be convenient to take, for making medicine.All medicines share the merit playing vigorate qi and replenish the blood, tranquilizing by nourishing the heart, invigorating the spleen and regulating the stomach altogether. Cure mainly deficiency of both QI and blood, show themselves in that shallow complexion, extremity asthenia, lazy speech of breathing hard, insomnia forgetfulness, inappetence etc..
The present invention, for treating the pharmaceutical composition of deficiency of both QI and blood, can make multiple dosage form in pharmaceutics, be preferably made Colla Corii Asini Cream, the preparation method of donkey-hide gelatin mate is:
1., medical material decocts and concentrates:
Remove ten taste medical materials outside Colla Corii Asini and maltose, add 10 times of weight water and soak 30 minutes, decoct three times, each 1 hour, Collecting decoction, filters, and filtrate is concentrated into the clear paste that relative density is 1.03-1.10, standby；
2., Colla Corii Asini molten:
A certain amount of yellow wine is put in Colla Corii Asini, did not had glue surface, stirring, infiltrate 24 hours, heated and stirred is uniform to glue；
3., sugar refinery:
The distilled water measuring sucrose weight 50% is put in container, is heated to boiling；It is subsequently adding sucrose, the most slowly adds Enter the tartaric acid edible of sucrose weight 0.1%, continue to be heated to sugar liquid and become " flag, beading of dripping are hung in wire drawing " shape, maltose；
4., cream is received:
Adding maltose and the glue of molten in clear paste after 1. step concentrates, little fire heating is received cream, to be obtained final product.
12 taste donkey-hide gelatin mate prepared by the present invention are a kind of prescriptions with nutritious tonifying and prophylactic treatment comprehensive function, and its prescription is Under the theoretical direction of differentiation of tcm and traditional Chinese medical science organic conception, obtained by the change of human body the bottom of heart yang blood and qi deficiency and excess, institute Chinese crude drug is selected all to meet the regulation of 2015 editions Chinese Pharmacopoeias, through soaking, decoct, concentrate, receiving the techniques such as cream, refined processing Forming, it is while nourishing, also have a merit of invigorating the spleen and regulating the stomach, it is to avoid the taste of cream side is greasy thick and heavy, hinders the phenomenon of digestion, patient Reflection is good, evident in efficacy.Meanwhile, preparation technology is simple, without other additives, pollution-free, environmental protection.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment 1
One, 12 taste donkey-hide gelatin mate, its effective ingredient is prepared by the raw material of Chinese medicine of following weight:
Two, the preparation method step of 12 taste donkey-hide gelatin mate is as follows:
1., medical material decocts and concentrates:
Remove ten taste medical materials outside Colla Corii Asini and maltose, add 10 times of weight water and soak 30 minutes, decoct three times, each 1 hour, Collecting decoction, filters, and filtrate is concentrated into the clear paste that relative density is 1.03-1.10 (20 DEG C), standby.
2., Colla Corii Asini molten:
A certain amount of yellow wine is put in Colla Corii Asini, did not had glue surface, stirring, infiltrate 24 hours, heated and stirred is uniform to glue.
3., sugar refinery:
The distilled water measuring sucrose weight 50% is put in container, is heated to boiling；It is subsequently adding sucrose, the most slowly adds Enter the tartaric acid edible of sucrose weight 0.1%, continue to be heated to sugar liquid and become " flag, beading of dripping are hung in wire drawing " shape, maltose.
4., cream is received:
Adding maltose and the glue of molten in clear paste after 1. step concentrates, little fire heating is received cream, is made finished product 1000g, i.e. ?.
Three, the comparitive study of deficiency of both QI and blood is treated
1. physical data:
Choose deficiency of both QI and blood patient 600 example that the second Affiliated Hospital of Anhui University of Chinese Medecine accepts for medical treatment.Selected patient uses random number Word table method is divided into FUFANG EJIAO JIANG group and 12 taste donkey-hide gelatin mate groups, often organizes each 300 examples, and two groups of patients are at the state of an illness, sex, age And the aspect such as the course of disease has comparability.
2. Therapeutic Method:
Treatment group uses 12 taste donkey-hide gelatin mate to treat；Matched group uses FUFANG EJIAO JIANG (Donga, the Shandong limited public affairs of Colla Corii Asini share Department, 20ml*12 props up/box) treatment.
Treatment group: boiled water is taken after mixing it with water, daily 2 times, each soupspoon (about 25g), within two weeks, it is a course for the treatment of, is used in conjunction four The course for the treatment of.
Matched group: daily 3 times, one time one, within two weeks, be a course for the treatment of, be used in conjunction four courses for the treatment of.
3. criterion of therapeutical effect:
Anemia evaluation of clinical curative effect is carried out according to " diagnosis of hematological diseases and criterion of therapeutical effect ":
Curing: clinical symptoms is wholly absent, Hb (hemoglobin) amount recovers normal, and keeps normally reaching more than 3 months.
Effective: clinical symptoms is clearly better, Hb (hemoglobin) amount significantly increases.
Invalid: clinical symptoms is unchanged.
4. efficacy evaluation result:
Group Case load Cure rate (number of cases) Improvement rate (number of cases) Do not heal rate (number of cases) Total effective rate (number of cases)
Treatment group 300 22% (66) 69% (207)* 16% (48) 91% (273)*
Matched group 300 16% (48) 55% (165) 33% (99) 71% (213)
Note: total effective rate compared with matched group,*P ＜ 0.05
From upper table, compared with matched group, the effective percentage for the treatment of group and total effective rate are above matched group, treatment group Curative effect is the most notable.
Embodiment 2
A kind of pharmaceutical composition for treating deficiency of both QI and blood, its effective ingredient is prepared by the raw material of Chinese medicine of following weight:
Embodiment 3
A kind of pharmaceutical composition for treating deficiency of both QI and blood, its effective ingredient is prepared by the raw material of Chinese medicine of following weight:
Embodiment 4
A kind of pharmaceutical composition for treating deficiency of both QI and blood, its effective ingredient is prepared by the raw material of Chinese medicine of following weight:
Embodiment 5
A kind of pharmaceutical composition for treating deficiency of both QI and blood, its effective ingredient is prepared by the raw material of Chinese medicine of following weight:

Claims (6)

1. the pharmaceutical composition being used for treating deficiency of both QI and blood, it is characterised in that its effective ingredient is by the Chinese medicine of following weight Raw material prepares:
2. the pharmaceutical composition for treating deficiency of both QI and blood as claimed in claim 1, it is characterised in that its effective ingredient by The raw material of Chinese medicine of following weight prepares:
3. the pharmaceutical composition for treating deficiency of both QI and blood as claimed in claim 2, it is characterised in that its effective ingredient by The raw material of Chinese medicine of following weight prepares:
4. the pharmaceutical composition for treating deficiency of both QI and blood as described in claim 1 or 2 or 3, it is characterised in that Colla Corii Asini Making glue through molten, preparation method, for put in Colla Corii Asini by a certain amount of yellow wine, there was not glue surface, stirring, infiltrated 24 hours, Heated and stirred is uniform to glue.
5. the pharmaceutical composition for treating deficiency of both QI and blood as described in claim 1 or 2 or 3, it is characterised in that maltose Preparation method be: the distilled water measuring sucrose weight 50% is put in container, be heated to boiling；It is subsequently adding sucrose, is stirring Mix down the tartaric acid edible slowly adding sucrose weight 0.1%, continue to be heated to sugar liquid and become " flag, beading of dripping are hung in wire drawing " shape, Maltose.
6. the method being prepared 12 taste donkey-hide gelatin mate by pharmaceutical composition described in claim 1 or 2 or 3, it is characterised in that Step is:
1., medical material decocts and concentrates:
Remove ten taste medical materials outside Colla Corii Asini and maltose, add 10 times of weight water and soak 30 minutes, decoct three times, each 1 hour, Collecting decoction, filters, and filtrate is concentrated into the clear paste that relative density is 1.03-1.10, standby；
2., Colla Corii Asini molten:
A certain amount of yellow wine is put in Colla Corii Asini, did not had glue surface, stirring, infiltrate 24 hours, heated and stirred is uniform to glue；
3., sugar refinery:
The distilled water measuring sucrose weight 50% is put in container, is heated to boiling；It is subsequently adding sucrose, the most slowly adds Enter the tartaric acid edible of sucrose weight 0.1%, continue to be heated to sugar liquid and become " flag, beading of dripping are hung in wire drawing " shape, maltose；
4., cream is received:
Adding maltose and the glue of molten in clear paste after 1. step concentrates, little fire heating is received cream, to be obtained final product.
CN201610482244.7A 2016-06-24 2016-06-24 Pharmaceutical composition and preparation method thereof for treating syndrome of deficiency of both qi and blood Active CN105878851B (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106692675A (en) * 2017-03-21 2017-05-24 南京苏新智慧社区服务有限公司 Soft extract for nourishing qi and invigorating the circulation of blood, as well as preparation method and application thereof
CN112616984A (en) * 2020-12-15 2021-04-09 盛秀群 Donkey-hide gelatin maltose capable of tonifying qi, enriching blood, maintaining beauty and keeping young

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Publication number Priority date Publication date Assignee Title
CN102319410A (en) * 2011-09-13 2012-01-18 成美娜 Vital energy invigorating and blood nourishing traditional Chinese medicine composition, and preparation method thereof
CN103751518A (en) * 2014-01-14 2014-04-30 安徽九方制药有限公司 Oral liquid for tonifying Qi and replenishing blood and preparation method thereof
CN103751415A (en) * 2013-12-31 2014-04-30 山东东阿阿胶股份有限公司 Traditional Chinese medicinal composition and preparation method thereof
CN104666868A (en) * 2015-01-07 2015-06-03 江怀 Medicine for treating yin diseases caused by deficiency syndrome

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Publication number Priority date Publication date Assignee Title
CN102319410A (en) * 2011-09-13 2012-01-18 成美娜 Vital energy invigorating and blood nourishing traditional Chinese medicine composition, and preparation method thereof
CN103751415A (en) * 2013-12-31 2014-04-30 山东东阿阿胶股份有限公司 Traditional Chinese medicinal composition and preparation method thereof
CN103751518A (en) * 2014-01-14 2014-04-30 安徽九方制药有限公司 Oral liquid for tonifying Qi and replenishing blood and preparation method thereof
CN104666868A (en) * 2015-01-07 2015-06-03 江怀 Medicine for treating yin diseases caused by deficiency syndrome

Non-Patent Citations (1)

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Title
姚岳: "崩漏证治", 《四川中医》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106692675A (en) * 2017-03-21 2017-05-24 南京苏新智慧社区服务有限公司 Soft extract for nourishing qi and invigorating the circulation of blood, as well as preparation method and application thereof
CN112616984A (en) * 2020-12-15 2021-04-09 盛秀群 Donkey-hide gelatin maltose capable of tonifying qi, enriching blood, maintaining beauty and keeping young

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