CN105878833A - 一种治疗尿毒症的中药组合物 - Google Patents

一种治疗尿毒症的中药组合物 Download PDF

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CN105878833A
CN105878833A CN201610250210.5A CN201610250210A CN105878833A CN 105878833 A CN105878833 A CN 105878833A CN 201610250210 A CN201610250210 A CN 201610250210A CN 105878833 A CN105878833 A CN 105878833A
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周美德
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Abstract

本发明公开一种治疗尿毒症的中药组合物。该组合物由大腹皮、茵陈、潘泻叶、商陆、路路通、白术、白茯苓、虎杖、白芪、穿山甲(炮)、麝香、鳖甲(焙)等22味原料药组成。本发明中药组合物按照常规工艺加入常规辅料制成临床接受的胶囊剂、片剂、丸剂、颗粒剂或口服液。本发明药物组合物的优点在于可以有效治疗尿毒症，可以避免透析给患者带来身体的进一步伤害，减轻患者经济负担，延长患者生存期和提高患者生活质量。且无毒副作用，治疗尿毒症的有效率为99％。

Description

一种治疗尿毒症的中药组合物
技术领域
本发明涉及一种药物组合物，特别是涉及一种治疗尿毒症的中药组合物。
背景技术
尿毒症是肾功能衰竭晚期所发生的一系列症状的总称。慢性肾功能症状主要体现为有害物质积累引起的中毒和肾脏激素减少发生的贫血合骨病。早期最常见的是恶心、呕吐、食欲减退等消化道症状。进入晚期尿毒症阶段后，全身系统都会受累，出现心力衰竭、精神异常、昏迷等严重症状，甚至危及生命。可见，尿毒症是一种非常可怕的病症。过去认为尿毒症是不治之症，自本世纪开始之后开展了透析方法及肾移植手术，使得尿毒症病人的寿命得以明显的延长。但是，做透析或者肾移植手术的费用是相当昂贵的，对于那些低收入人群根本负担不起。而且，对病人做透析或者肾移植手术，极大地增加了病人的痛苦。尿毒症目前在我过的发病保守来说将近两百万人，每年新发病人数以20％左右的速度递增，尿毒症大部分是由慢性肾小球肾炎引起的肾功能衰竭而导致的，慢性肾性的病人将近有30％晚期会发展成为尿毒症。如何在既能使大多数的病人在经济上可接受，又能减低病人所受到的痛苦的情况下医治尿毒症，成为业界亟待解决的问题。
发明内容
本发明目的在于提供一种治疗尿毒症的中药组合物。
本发明是通过如下技术方案实现的：
本发明中药组合物的原料药组成为：
本发明中药组合物的原料药组成为：
本发明中药组合物的原料药组成优选为：
本发明中药组合物的原料药组成优选为：
本发明中药组合物的原料药组成优选为：
本发明中药组合物按照常规工艺加入常规辅料制成临床接受的胶囊剂、片剂、丸剂、颗粒剂或口服液。
本发明药物组合物的优点在于可以有效治疗尿毒症，可以避免透析给患者带来身体的进一步伤害，减轻患者经济负担，延长患者生存期和提高患者生活质量。且无毒副作用，治疗尿毒症的有效率为99％。
下面实验例用于进一步说明本发明，但不限于本发明。
实验例一：临床试验
1、临床观察
临床观察100例尿毒症患者，年龄45-75岁，男性50例，女性50例。100例患者均全部符合尿毒症诊断标准。
2、药物选择
治疗组选用本发明丸剂(按照实施例1方法制备)，每粒0.25g，每次2粒，每日三次，服药6个月。
3、疗效标准
治愈：临床症状体征消失，恢复正常。
显效：临床症状体征基本或大部分消失。
有效：临床症状明显好转。
无效：临床症状体征无改善。
4、治疗结果
表1治疗结果
组别 显效(例) 有效(例) 无效(例) 总有效(例) 有效率
治疗组 75 24 1 99 99％
表2生存时间
组别 1年以上 3年以上 5年以上 10年以上
治疗组 99例 95例 88例 69例
5、结论
治疗组患者治疗6个月，总有效率为98％，99例患者生存1年以上，生存3年以上的95例，生存5年以上的88例，生存10年以上的69例。
实验例二、典型病例
病例1：秦某，女，51岁，2003年8月患肾病住市医院诊断为“慢性肾功能衰竭”(尿毒症期)使用大量激素及结合透析和输血一年后，由于患者经济困难不能维持治疗，慕名前来寻找中医，透析后化验，血肌酐867umol/L，血尿素氮40mmol/L，三天后透析前化验上升至血肌酐1070umol/L，血尿素氮47mmol/L，血红蛋白70g/L。服用本发明丸剂(按照实施例1方法制备)，每次2粒，每日三次，2个月后化验血肌酐下降至496umol/L，血尿素氮31mmol/L，血红蛋白90g/L。继续服用2个月后，化验血肌酐280umol/L，血尿素氮18.5mmol/L，血红蛋白105g/L。继续服药2个月后，生活质量接近正常人至今。
病例2：赵某某，男，47岁，农民，2005年春季因肾病住某县医院，后转市级医院，经西医治疗后，病情不能缓解，肌酐958umol/L，尿素氮39mmol/L，医院要求血液透析，并服激素50mg/日，患者经济困难，访问我院中医治疗，经服本发明胶囊剂(按照实施例2方法制备)，每日服药三次，每次二粒，4个月后，血肌酐降至280umol/L，血尿素氧10mmol/L，继续服药2个月血肌酐降至195umol/L，血尿素氮9mmol/L，血红蛋白由45g/L逐渐上升至110g/L，精神焕发，声音洪亮。，2015年随访，无复发，生活质量接近常人。
病例3：孙某某，女，16岁、学生，2003年10月在上学期间感到身体不适，到市某医院全面检查为“红斑狼疮性肾炎”，住院西医治疗，一直不能痊愈，时好时坏，在治疗三年中的2006年1月病情突然加重，发展为“尿毒症”，继续住院治疗10个月后，血肌酐1090umol/L，尿素氮40mmol/L，不得不做透析，开始每周3次透析，并结合输血，2007年1月30日慕名前来我院治疗。患者面色灰黯，口唇淡白，脉滑数有力，血压180/110Hmmg。经服用本发明片剂(按照实施例3方法制备)，每日三次，每次2片，服用2个月后血肌酐下降至500umol/L，尿素氧28mmol/L，血压140/90Hmmg，继续服药2个月后血肌酐下降至340umol/L，尿素氧13mmol/L，血压正常，血红蛋白升至105g/L，继续服药一个月巩固，2015年随访病情稳定，生活质量如常人。
下述实施例均能实现上述实验例的效果。
具体实施方式
实施例1 丸剂
上述药物按照常规工艺加入常规辅料制成丸剂，每粒0.25g，每次2粒，每日三次。
实施例2 胶囊剂
上述药物按照常规工艺加入常规辅料制成胶囊剂，每次2粒，每日三次。
实施例3 片剂
上述药物按照常规工艺加入常规辅料制成片剂，每次2片，每日三次。
实施例4 颗粒剂
上述药物按照常规工艺加入常规辅料制成颗粒剂，每袋10g，一日三次，一次1袋。
实施例5 口服液
上述药物按照常规工艺加入常规辅料制成口服液。10ml/支，每日三次，每次1支。

Claims (9)

1.一种治疗尿毒症的中药组合物，其特征在于，该组合物的原料药组成为：
2.如权利要求1所述的中药组合物，其特征在于该组合物的原料药组成为：
3.如权利要求1或2所述的中药组合物，其特征在于该组合物的原料药组成为：
4.如权利要求1所述的中药组合物，其特征在于该组合物的原料药组成为：
5.如权利要求1所述的中药组合物，其特征在于该组合物的原料药组成为：
6.如权利要求1、2、4或5所述的中药组合物，其特征在于该组合物按照常规工艺加入常规辅料制成临床接受的胶囊剂、片剂、丸剂、颗粒剂或口服液。
7.如权利要求3所述的中药组合物，其特征在于该组合物按照常规工艺加入常规辅料制成临床接受的胶囊剂、片剂、丸剂、颗粒剂或口服液。
8.如权利要求1、2、4或5所述的中药组合物在制备治疗尿毒症的药物中的应用。
9.如权利要求3所述的中药组合物在制备治疗尿毒症的药物中的应用。
CN201610250210.5A 2016-04-15 2016-04-15 一种治疗尿毒症的中药组合物 Pending CN105878833A (zh)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101444598A (zh) * 2007-11-27 2009-06-03 陈金宗 一种治疗尿毒症的中药组合物及其制备方法和用途
CN102488860A (zh) * 2011-12-16 2012-06-13 刘云 治疗慢性尿毒症的中药组合物及其制备方法
CN103083417A (zh) * 2012-12-26 2013-05-08 林杨 治疗尿毒症的药物组合物及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101444598A (zh) * 2007-11-27 2009-06-03 陈金宗 一种治疗尿毒症的中药组合物及其制备方法和用途
CN102488860A (zh) * 2011-12-16 2012-06-13 刘云 治疗慢性尿毒症的中药组合物及其制备方法
CN103083417A (zh) * 2012-12-26 2013-05-08 林杨 治疗尿毒症的药物组合物及其制备方法

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