CN105878636A - Traditional Chinese medicine for treating neurasthenia - Google Patents
Traditional Chinese medicine for treating neurasthenia Download PDFInfo
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- CN105878636A CN105878636A CN201510492006.XA CN201510492006A CN105878636A CN 105878636 A CN105878636 A CN 105878636A CN 201510492006 A CN201510492006 A CN 201510492006A CN 105878636 A CN105878636 A CN 105878636A
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Abstract
The invention discloses a traditional Chinese medicine for treating neurasthenia. The traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: 63-93 parts of tuber fleeceflower stem, 60-90 parts of autumn zephyrlily herb, 58-88 parts of roots of sharpleaf gambirplant, 56-86 parts of all-grass of cruciate buchnera, 53-83 parts of rhizoma arisaematis, 48-78 parts of rhizoma pinelliae, 45-75 parts of kansui roots, 43-73 parts of Korean mondshood root, 41-71 parts of lowdaphne stringbush flowers and leaves, 38-68 parts of stem or leaf of Chu-lan tree, 36-66 parts of hemp spike, 34-64 parts of valerian root, 32-62 parts of all-grass of cladonia fallax abbayes, 28-58 parts of herba potentillae chinensis, 27-57 parts of radix semiaquilegiae, and 22-52 parts of azurite. The invention aims at providing the traditional Chinese medicine for treating neurasthenia, the clinical application range of traditional Chinese medicine is expanded, and the waste of the good medicinal resource is avoided.
Description
Technical field
The present invention relates to pharmaceutical technology field, specifically one prepares the neurasthenic Chinese medicine for the treatment of.
Background technology
Neurasthenia is a kind of commonly encountered diseases, clinical manifestation is insomnia, forgetful, fidgety, dreaminess, dizziness, nervous, spiritlessness and weakness, soreness of the waist and knees etc..Modern medicine thinks that its pathogenic factor is influenced each other by many factors, interacts and cause normal brain activity neural " excited and suppression " process obstacle.In treatment, modern medicine advocates on the one hand to adopt psychotherapy, and on the one hand uses chemotherapy.Chemicals only has symptomatic treatment effect for neurasthenia, and the most with the most use is antianxiety drug, such as tranquilizer.Antianxiety drug has and improves the mood of patient neurasthenia, makes muscular flaccidity and tranquilizing soporific etc. act on.Therefore, effective to psychology, the physiological signs of patient.But, antianxiety drug only has short-period used just to have preferable effect, long-term taking not only weak curative effect, is also easy to cause drug dependence.And the delay of its stadium of neurasthenia, the chemicals symptomatic treatment of short-term, it is impossible to tackle the problem at its root.
The prescription of the present invention is in disclosing as the medicine treating epilepsy on November 19th, 2014 after in the application of Chinese patent 201410440282.7, we find that in a large amount of clinical practices the party is in addition to curing mainly function, also there is the neurasthenic good efficacy for the treatment of, not only onset is rapid, curative effect lasting, and untoward reaction is few.The clinical application new in order to develop this medicine further, reduces the wasting of resources of medicine, this medicine has been carried out a series of drug effect and dosage form research, has taken a firm foundation for widely clinical practice.
Summary of the invention
It is an object of the invention to provide the new therapeutic use of a kind of Chinese medicine composition, specifically one and prepare the neurasthenic Chinese medicine for the treatment of.
For achieving the above object, the present invention provides following technical scheme:
One prepares the neurasthenic Chinese medicine for the treatment of, in parts by weight, the raw material making this Chinese medicine composition active component is: Caulis Polygoni Multiflori 63～93 parts, Herba Zephyranthis Candidae 60～90 parts, Radix Uncariae rhynchophyllae 58～88 parts, Ramulus Euonymi (Herba Buchnerae cruciatae) 56～86 parts, Rhizoma Arisaematis 53～83 parts, the Rhizoma Pinelliae 48～78 parts, Radix Kansui 45～75 parts, Radix Aconiti Coreani 43～73 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 41～71 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 38～68 parts, fiber crops 36～66 parts, Rhizoma et radix valerianae 34～64 parts, Cladonia fallax Abbayes 32～62 parts, Herba Potentillae Chinensis 28～58 parts, Radix Semiaquilegiae 27～57 parts and Azuritum 22～52 parts.Chinese medicine composition of the present invention has tranquillizing and allaying excitement, coordinates internal organs, effect of invigorating the spleen and benefiting QI, and current clinic is only used for the treatment to epileptic condition.
As the further scheme of the present invention: in parts by weight, the raw material making this Chinese medicine composition active component is: Caulis Polygoni Multiflori 85 parts, Herba Zephyranthis Candidae 82 parts, Radix Uncariae rhynchophyllae 80 parts, Ramulus Euonymi (Herba Buchnerae cruciatae) 78 parts, Rhizoma Arisaematis 75 parts, the Rhizoma Pinelliae 70 parts, Radix Kansui 68 parts, Radix Aconiti Coreani 65 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 64 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 60 parts, fiber crops 58 parts, Rhizoma et radix valerianae 56 parts, Cladonia fallax Abbayes 55 parts, Herba Potentillae Chinensis 51 parts, Radix Semiaquilegiae 50 parts and Azuritum 45 parts.
As the further scheme of the present invention: in parts by weight, the raw material making this Chinese medicine composition active component is: Caulis Polygoni Multiflori 77 parts, Herba Zephyranthis Candidae 75 parts, Radix Uncariae rhynchophyllae 73 parts, Ramulus Euonymi (Herba Buchnerae cruciatae) 71 parts, Rhizoma Arisaematis 68 parts, the Rhizoma Pinelliae 63 parts, Radix Kansui 59 parts, Radix Aconiti Coreani 58 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 57 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 53 parts, fiber crops 49 parts, Rhizoma et radix valerianae 49 parts, Cladonia fallax Abbayes 48 parts, Herba Potentillae Chinensis 44 parts, Radix Semiaquilegiae 43 parts and Azuritum 38 parts.
As the further scheme of the present invention: in parts by weight, the raw material making this Chinese medicine composition active component is: Caulis Polygoni Multiflori 70 parts, Herba Zephyranthis Candidae 67 parts, Radix Uncariae rhynchophyllae 66 parts, Ramulus Euonymi (Herba Buchnerae cruciatae) 64 parts, Rhizoma Arisaematis 61 parts, the Rhizoma Pinelliae 56 parts, Radix Kansui 53 parts, Radix Aconiti Coreani 51 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 49 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 46 parts, fiber crops 44 parts, Rhizoma et radix valerianae 42 parts, Cladonia fallax Abbayes 40 parts, Herba Potentillae Chinensis 36 parts, Radix Semiaquilegiae 36 parts and Azuritum 31 parts.
As the further scheme of the present invention: described Chinese medicine composition contains pharmaceutically acceptable oral formulations adjuvant.
The preparation method of Chinese medicine composition of the present invention, comprises the following steps:
(1) taking Caulis Polygoni Multiflori, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis), Cladonia fallax Abbayes and Herba Potentillae Chinensis and go the removal of impurity, mix thoroughly vexed with vinegar water, the micro-stir-fry of slow fire, taking-up is dried, and grinds into powder in being placed in mortar, crosses 180 mesh fine powders, standby；
(2) take Herba Zephyranthis Candidae, Radix Uncariae rhynchophyllae, fiber crops and Rhizoma et radix valerianae decontamination, clean, put into container, add the distilled water of 7～9 times amount, after soaking 3～4 hours, boil 2～3 hours, extract；Again add 4～6 times amount distilled water, boil 1～2 hour, extract；It is eventually adding 2～3 times amount distilled water, heated and boiled 1～2 hours, extracts；Merge three extracting solution, filter, obtain filtrate, standby；
(3) take Ramulus Euonymi (Herba Buchnerae cruciatae), Radix Aconiti Coreani, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) and Radix Semiaquilegiae decontamination, clean, put into container, add 5 times amount soaking in Chinese liquor 4～after 5 hours, add 10 times amount distilled water and decoct 3～4 hours, extract decoction liquor afterwards；Again add 3 times amount Chinese liquor and 7 times amount distilled water, decoct 2～3 hours, extract decoction liquor afterwards；Merge 2 decoction liquor, obtain filtrate, filtrate is condensed at 60 DEG C the thick paste of 1.15～1.25 times, drying under reduced pressure, standby；
(4) take Rhizoma Arisaematis, the Rhizoma Pinelliae, Radix Kansui and Azuritum decontamination, after drying, grind into powder in being placed in mortar, cross 200 mesh fine powders, standby；
(5) thick paste of the filtrate obtained by step (1) and the fine powder of step (4) gained, step (2), step (3) gained is mixed, make tablet, be the neurasthenic Chinese medicine composition for the treatment of of the present invention.
The instructions of taking of Chinese medicine composition of the present invention: oral, every day twice, point morning, evening twice, each 3, warm water delivery service half an hour after meal, 20 days is a course for the treatment of, takes 1～3 course for the treatment of.
The present invention finds that in substantial amounts of clinical practice it has a significantly treatment neurasthenia effect, therefore, we the present invention is treated neurasthenic new application carried out deeper into research, it is existing that by main effect experiment, details are as follows:
Experiment 1: Chinese medicine composition of the present invention causes the test of mouse memory acquired disturbance to scopolamine
1, test material:
The preparation of 1.1 trial drugs:
(1) taking Caulis Polygoni Multiflori 77 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 57 parts, Cladonia fallax Abbayes 48 parts and Herba Potentillae Chinensis 44 parts and go the removal of impurity, mix thoroughly vexed with vinegar water, the micro-stir-fry of slow fire, taking-up is dried, and grinds into powder in being placed in mortar, crosses 180 mesh fine powders, standby；
(2) take Herba Zephyranthis Candidae 75 parts, Radix Uncariae rhynchophyllae 73 parts, fiber crops 49 parts and 49 parts of decontaminations of Rhizoma et radix valerianae, clean, put into container, add the distilled water of 7～9 times amount, after soaking 3～4 hours, boil 2～3 hours, extract；Again add 4～6 times amount distilled water, boil 1～2 hour, extract；It is eventually adding 2～3 times amount distilled water, heated and boiled 1～2 hours, extracts；Merge three extracting solution, filter, obtain filtrate, standby；
(3) take Ramulus Euonymi (Herba Buchnerae cruciatae) 71 parts, Radix Aconiti Coreani 58 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 53 parts and 43 parts of decontaminations of Radix Semiaquilegiae, clean, put into container, add 5 times amount soaking in Chinese liquor 4～after 5 hours, add 10 times amount distilled water and decoct 3～4 hours, extract decoction liquor afterwards；Again add 3 times amount Chinese liquor and 7 times amount distilled water, decoct 2～3 hours, extract decoction liquor afterwards；Merge 2 decoction liquor, obtain filtrate, filtrate is condensed at 60 DEG C the thick paste of 1.15～1.25 times, drying under reduced pressure, standby；
(4) take Rhizoma Arisaematis 68 parts, the Rhizoma Pinelliae 63 parts, Radix Kansui 59 parts and 38 parts of decontaminations of Azuritum, after drying, grind into powder in being placed in mortar, cross 200 mesh fine powders, standby；
(5) thick paste of the filtrate obtained by step (1) and the fine powder of step (4) gained, step (2), step (3) gained is mixed, make tablet, be the neurasthenic Chinese medicine composition for the treatment of of the present invention.
1.2 medicines: Chinese medicine composition of the present invention grinds into the last oral liquid (10ml, 1g crude drug/ml) mixed with water；Scopolamine hydrobromide injection (0.3mg/ props up), Xuzhou Lai En pharmaceutcal corporation, Ltd；
Animal: white mice, body weight 30-32g, male and female half and half；
Instrument: mice electric shock diving tower device.
2, test method:
100 mices are randomly divided into 5 groups, it is respectively Normal group, model control group, dosage group (16g crude drug/kg), Chinese medicine composition heavy dose group of the present invention (32g crude drug/kg) in Chinese medicine composition small dose group of the present invention (8g crude drug/kg), Chinese medicine composition of the present invention, often group 20, male and female half and half, raise under similarity condition.Once, capacity is 0.2ml/10g body weight to administration group gastric infusion every day, and Normal group, model control group such as give every day at the capacity normal saline, continuous 12 days.In addition to Normal group, remaining is respectively organized mice and was all administered after 20,30 minutes at last two days, lumbar injection scopolamine 4mg/kg, and last starts training to scopolamine after 30 minutes.During training, mice is put into reflective box, first adapt to 3 minutes, be then electrified to.When animal is shocked by electricity, normal reaction be rebound diving tower to hide electric shock, mice biped copper grid for get an electric shock, be considered as wrong reaction.Train 5 minutes and record mice wrong reaction number of times in 5 minutes.Test after 24 hours, record wrong reaction number of times in 5 minutes wrong reaction number of times, i.e. 5 minutes phases of memory.T inspection is used respectively to organize difference condition.
3, result of the test is shown in Table 1
Table 1 Chinese medicine composition of the present invention causes the impact (x ± s) of mouse memory acquired disturbance to scopolamine hydrobromide
Note: compare with model control group: * P ＜ 0.05；* P ＜ 0.01.
From result, model control group mice is errors number obvious compared with normal matched group many (P ＜ 0.01) within 5 minutes training periods, illustrates that mice is to causing memory acquisition disturbance after scopolamine.In 5 minutes, errors number is substantially few compared with model control group (P ＜ 0.01) within training period to take the mice of Chinese medicine composition of the present invention.Within the memory phase, 5 minutes errors number obvious compared with normal matched groups many (P ＜ 0.05) of model control group mice, taking the mice of Chinese medicine composition of the present invention in 5 minutes, errors number is substantially few compared with model control group (P ＜ 0.05).This shows, Chinese medicine composition of the present invention can obviously improve scopolamine and causes mouse memory acquired disturbance.Therefore, Chinese medicine composition of the present invention is applied on clinical treatment, the following is clinical data.
Clinical data
1, physical data
Selection of clinical patient 200 example, the maleest 100 examples, female 100 example, wherein 15-45 year 100 examples, 46-55 year 50 examples, 56-65 year 50 examples.
2, diagnostic criteria
Diagnostic criteria is drafted with reference to " tcm clinical practice disease Standardization of diagnosis and curative effect " [the 6th edition " Chinese Internal Medicine "].(1) classical symptom: difficulty falling asleep or sleep and easily wake up, sleeps and unstable or can not sleep after waking up；Morning wakes up too early；Or lie awake all night, do not have enough sleep 5h.(2) simultaneous phenomenon: often companion's giddy headache, palpitation and amnesia, spiritlessness and weakness, malaise, dreaminess etc..(3) there is history of repeated attack.(4) through each system and lab testing, other organic diseases nypnapagogic are found no.
Curative effect determinate standard is with reference to " tcm clinical practice disease Standardization of diagnosis and curative effect ", and concrete curative effect determinate standard is as follows:
Recovery from illness: recover the length of one's sleep normal, or nighttime sleep is at more than 6h, sleeps deep, hale and hearty after waking up, follow up a case by regular visits to 2 years without recurrence.
Effective: sleep is clearly better, increase more than 3h the length of one's sleep, Depth of sleep increases, and after waking up, spirit preferably, follows up a case by regular visits to 2 years not recur；Or having slight recurrence, symptom after taking medicine disappears.
Effective: symptom alleviates, the length of one's sleep increases ＜ 3h earlier above, and simultaneous phenomenon alleviates.
Invalid: after treatment, insomnia is not improved.
3, Therapeutic Method
Using the tablet made of embodiment 1, every day is early, evening respectively takes 3 to patient, within 20 days, is a course for the treatment of, minimum takes 3 courses for the treatment of.
4, therapeutic outcome:
Result after 3 courses for the treatment of: clinical recovery 84 people；Effective 78 people；Effective 32 people；Invalid 6 people；The present invention reaches 42% to insomniac's cure rate, and effective percentage is 97%, and invalid 3%.Wherein refractory patient 6 people is all about 50 years old women, and the own self emotion regulation of main cause system is out of control causes curative effect not good enough.
Untoward reaction and toxic and side effects monitoring
By detection the blood pressure of patient, pulse, whether Nausea and vomiting occurs, the clinical symptoms of dizziness judges untoward reaction.Set human normal contraction to be pressed between 90-140mmHg, diastolic pressure is between 60-90mmHg, human normal pulse is 60-100 beat/min, the blood pressure of patient, pulse is measured during treating, find that the blood pressure and pulse recorded was all within normal range, phenomenon without departing from normal interval occurs, and the clinical symptoms of Nausea and vomiting, dizziness does not occur.The pharmaceutical composition of this explanation present invention does not has obvious untoward reaction, and then proves that this medicine does not has obvious toxic and side effects for human body.
Compared with prior art, the invention has the beneficial effects as follows:
1, this traditional Chinese medicine composition for treating neurasthenia has no side effect, and it is low to have price, it is easy to the advantage such as be accepted by patients；
2, this Chinese medicine composition abundant raw materials, preparation technology is simple, environmentally friendly, and in treatment, neurasthenia has good application prospect；
3, the present invention improves the clinical application range of this Chinese medicine composition, is prevented effectively from the waste of good drug resource.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, broadly fall into the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, one prepares the neurasthenic Chinese medicine for the treatment of, in parts by weight, the raw material making this Chinese medicine composition active component is: Caulis Polygoni Multiflori 63 parts, Herba Zephyranthis Candidae 90 parts, Radix Uncariae rhynchophyllae 58 parts, Ramulus Euonymi (Herba Buchnerae cruciatae) 86 parts, Rhizoma Arisaematis 53 parts, the Rhizoma Pinelliae 78 parts, Radix Kansui 45 parts, Radix Aconiti Coreani 73 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 41 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 68 parts, fiber crops 36 parts, Rhizoma et radix valerianae 64 parts, Cladonia fallax Abbayes 32 parts, Herba Potentillae Chinensis 58 parts, Radix Semiaquilegiae 27 parts and Azuritum 52 parts.
The preparation method of Chinese medicine composition of the present invention, comprises the following steps:
(1) taking Caulis Polygoni Multiflori, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis), Cladonia fallax Abbayes and Herba Potentillae Chinensis and go the removal of impurity, mix thoroughly vexed with vinegar water, the micro-stir-fry of slow fire, taking-up is dried, and grinds into powder in being placed in mortar, crosses 180 mesh fine powders, standby；
(2) take Herba Zephyranthis Candidae, Radix Uncariae rhynchophyllae, fiber crops and Rhizoma et radix valerianae decontamination, clean, put into container, add the distilled water of 7 times amount, after soaking 3 hours, boil 2 hours, extract；Again add 4 times amount distilled water, boil 1 hour, extract；It is eventually adding 2 times amount distilled water, heated and boiled 1 hour, extracts；Merge three extracting solution, filter, obtain filtrate, standby；
(3) take Ramulus Euonymi (Herba Buchnerae cruciatae), Radix Aconiti Coreani, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) and Radix Semiaquilegiae decontamination, clean, put into container, add 5 times amount soaking in Chinese liquor after 5 hours, add 10 times amount distilled water and decoct 4 hours, extract decoction liquor afterwards；Again add 3 times amount Chinese liquor and 7 times amount distilled water, decoct 3 hours, extract decoction liquor afterwards；Merge 2 decoction liquor, obtain filtrate, filtrate is condensed at 60 DEG C the thick paste of 1.15～1.25 times, drying under reduced pressure, standby；
(4) take Rhizoma Arisaematis, the Rhizoma Pinelliae, Radix Kansui and Azuritum decontamination, after drying, grind into powder in being placed in mortar, cross 200 mesh fine powders, standby；
(5) thick paste of the filtrate obtained by step (1) and the fine powder of step (4) gained, step (2), step (3) gained is mixed, make tablet, be the neurasthenic Chinese medicine composition for the treatment of of the present invention.
Embodiment 2
In the embodiment of the present invention, one prepares the neurasthenic Chinese medicine for the treatment of, in parts by weight, the raw material making this Chinese medicine composition active component is: Caulis Polygoni Multiflori 85 parts, Herba Zephyranthis Candidae 82 parts, Radix Uncariae rhynchophyllae 80 parts, Ramulus Euonymi (Herba Buchnerae cruciatae) 78 parts, Rhizoma Arisaematis 75 parts, the Rhizoma Pinelliae 70 parts, Radix Kansui 68 parts, Radix Aconiti Coreani 65 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 64 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 60 parts, fiber crops 58 parts, Rhizoma et radix valerianae 56 parts, Cladonia fallax Abbayes 55 parts, Herba Potentillae Chinensis 51 parts, Radix Semiaquilegiae 50 parts and Azuritum 45 parts.
The preparation method of Chinese medicine composition of the present invention, comprises the following steps:
(1) taking Caulis Polygoni Multiflori, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis), Cladonia fallax Abbayes and Herba Potentillae Chinensis and go the removal of impurity, mix thoroughly vexed with vinegar water, the micro-stir-fry of slow fire, taking-up is dried, and grinds into powder in being placed in mortar, crosses 180 mesh fine powders, standby；
(2) take Herba Zephyranthis Candidae, Radix Uncariae rhynchophyllae, fiber crops and Rhizoma et radix valerianae decontamination, clean, put into container, add the distilled water of 9 times amount, after soaking 4 hours, boil 3 hours, extract；Again add 6 times amount distilled water, boil 2 hours, extract；It is eventually adding 3 times amount distilled water, heated and boiled 2 hours, extracts；Merge three extracting solution, filter, obtain filtrate, standby；
(3) take Ramulus Euonymi (Herba Buchnerae cruciatae), Radix Aconiti Coreani, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) and Radix Semiaquilegiae decontamination, clean, put into container, add 5 times amount soaking in Chinese liquor after 5 hours, add 10 times amount distilled water and decoct 4 hours, extract decoction liquor afterwards；Again add 3 times amount Chinese liquor and 7 times amount distilled water, decoct 3 hours, extract decoction liquor afterwards；Merge 2 decoction liquor, obtain filtrate, filtrate is condensed at 60 DEG C the thick paste of 1.15～1.25 times, drying under reduced pressure, standby；
(4) take Rhizoma Arisaematis, the Rhizoma Pinelliae, Radix Kansui and Azuritum decontamination, after drying, grind into powder in being placed in mortar, cross 200 mesh fine powders, standby；
(5) thick paste of the filtrate obtained by step (1) and the fine powder of step (4) gained, step (2), step (3) gained is mixed, make tablet, be the neurasthenic Chinese medicine composition for the treatment of of the present invention.
Embodiment 3
In the embodiment of the present invention, one prepares the neurasthenic Chinese medicine for the treatment of, in parts by weight, the raw material making this Chinese medicine composition active component is: Caulis Polygoni Multiflori 77 parts, Herba Zephyranthis Candidae 75 parts, Radix Uncariae rhynchophyllae 73 parts, Ramulus Euonymi (Herba Buchnerae cruciatae) 71 parts, Rhizoma Arisaematis 68 parts, the Rhizoma Pinelliae 63 parts, Radix Kansui 59 parts, Radix Aconiti Coreani 58 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 57 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 53 parts, fiber crops 49 parts, Rhizoma et radix valerianae 49 parts, Cladonia fallax Abbayes 48 parts, Herba Potentillae Chinensis 44 parts, Radix Semiaquilegiae 43 parts and Azuritum 38 parts.
The preparation method of Chinese medicine composition of the present invention, comprises the following steps:
(1) taking Caulis Polygoni Multiflori, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis), Cladonia fallax Abbayes and Herba Potentillae Chinensis and go the removal of impurity, mix thoroughly vexed with vinegar water, the micro-stir-fry of slow fire, taking-up is dried, and grinds into powder in being placed in mortar, crosses 180 mesh fine powders, standby；
(2) take Herba Zephyranthis Candidae, Radix Uncariae rhynchophyllae, fiber crops and Rhizoma et radix valerianae decontamination, clean, put into container, add the distilled water of 8 times amount, after soaking 3 hours, boil 3 hours, extract；Again add 5 times amount distilled water, boil 1 hour, extract；It is eventually adding 3 times amount distilled water, heated and boiled 2 hours, extracts；Merge three extracting solution, filter, obtain filtrate, standby；
(3) take Ramulus Euonymi (Herba Buchnerae cruciatae), Radix Aconiti Coreani, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) and Radix Semiaquilegiae decontamination, clean, put into container, add 5 times amount soaking in Chinese liquor after 4 hours, add 10 times amount distilled water and decoct 3 hours, extract decoction liquor afterwards；Again add 3 times amount Chinese liquor and 7 times amount distilled water, decoct 2 hours, extract decoction liquor afterwards；Merge 2 decoction liquor, obtain filtrate, filtrate is condensed at 60 DEG C the thick paste of 1.15～1.25 times, drying under reduced pressure, standby；
(4) take Rhizoma Arisaematis, the Rhizoma Pinelliae, Radix Kansui and Azuritum decontamination, after drying, grind into powder in being placed in mortar, cross 200 mesh fine powders, standby；
(5) thick paste of the filtrate obtained by step (1) and the fine powder of step (4) gained, step (2), step (3) gained is mixed, make tablet, be the neurasthenic Chinese medicine composition for the treatment of of the present invention.
Embodiment 4
In the embodiment of the present invention, one prepares the neurasthenic Chinese medicine for the treatment of, in parts by weight, the raw material making this Chinese medicine composition active component is: Caulis Polygoni Multiflori 70 parts, Herba Zephyranthis Candidae 67 parts, Radix Uncariae rhynchophyllae 66 parts, Ramulus Euonymi (Herba Buchnerae cruciatae) 64 parts, Rhizoma Arisaematis 61 parts, the Rhizoma Pinelliae 56 parts, Radix Kansui 53 parts, Radix Aconiti Coreani 51 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 49 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 46 parts, fiber crops 44 parts, Rhizoma et radix valerianae 42 parts, Cladonia fallax Abbayes 40 parts, Herba Potentillae Chinensis 36 parts, Radix Semiaquilegiae 36 parts and Azuritum 31 parts.
The preparation method of Chinese medicine composition of the present invention, comprises the following steps:
(1) taking Caulis Polygoni Multiflori, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis), Cladonia fallax Abbayes and Herba Potentillae Chinensis and go the removal of impurity, mix thoroughly vexed with vinegar water, the micro-stir-fry of slow fire, taking-up is dried, and grinds into powder in being placed in mortar, crosses 180 mesh fine powders, standby；
(2) take Herba Zephyranthis Candidae, Radix Uncariae rhynchophyllae, fiber crops and Rhizoma et radix valerianae decontamination, clean, put into container, add the distilled water of 9 times amount, after soaking 3 hours, boil 3 hours, extract；Again add 6 times amount distilled water, boil 2 hours, extract；It is eventually adding 3 times amount distilled water, heated and boiled 2 hours, extracts；Merge three extracting solution, filter, obtain filtrate, standby；
(3) take Ramulus Euonymi (Herba Buchnerae cruciatae), Radix Aconiti Coreani, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) and Radix Semiaquilegiae decontamination, clean, put into container, add 5 times amount soaking in Chinese liquor after 5 hours, add 10 times amount distilled water and decoct 4 hours, extract decoction liquor afterwards；Again add 3 times amount Chinese liquor and 7 times amount distilled water, decoct 3 hours, extract decoction liquor afterwards；Merge 2 decoction liquor, obtain filtrate, filtrate is condensed at 60 DEG C the thick paste of 1.15～1.25 times, drying under reduced pressure, standby；
(4) take Rhizoma Arisaematis, the Rhizoma Pinelliae, Radix Kansui and Azuritum decontamination, after drying, grind into powder in being placed in mortar, cross 200 mesh fine powders, standby；
(5) thick paste of the filtrate obtained by step (1) and the fine powder of step (4) gained, step (2), step (3) gained is mixed, make tablet, be the neurasthenic Chinese medicine composition for the treatment of of the present invention.
Embodiment 5
In the embodiment of the present invention, one prepares the neurasthenic Chinese medicine for the treatment of, in parts by weight, the raw material making this Chinese medicine composition active component is: Caulis Polygoni Multiflori 93 parts, Herba Zephyranthis Candidae 60 parts, Radix Uncariae rhynchophyllae 88 parts, Ramulus Euonymi (Herba Buchnerae cruciatae) 56 parts, Rhizoma Arisaematis 83 parts, the Rhizoma Pinelliae 48 parts, Radix Kansui 75 parts, Radix Aconiti Coreani 43 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 71 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 38 parts, fiber crops 66 parts, Rhizoma et radix valerianae 34 parts, Cladonia fallax Abbayes 62 parts, Herba Potentillae Chinensis 28 parts, Radix Semiaquilegiae 57 parts and Azuritum 22 parts.
The preparation method of Chinese medicine composition of the present invention, comprises the following steps:
(1) taking Caulis Polygoni Multiflori, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis), Cladonia fallax Abbayes and Herba Potentillae Chinensis and go the removal of impurity, mix thoroughly vexed with vinegar water, the micro-stir-fry of slow fire, taking-up is dried, and grinds into powder in being placed in mortar, crosses 180 mesh fine powders, standby；
(2) take Herba Zephyranthis Candidae, Radix Uncariae rhynchophyllae, fiber crops and Rhizoma et radix valerianae decontamination, clean, put into container, add the distilled water of 7 times amount, after soaking 3 hours, boil 2 hours, extract；Again add 4 times amount distilled water, boil 1 hour, extract；It is eventually adding 2 times amount distilled water, heated and boiled 1 hour, extracts；Merge three extracting solution, filter, obtain filtrate, standby；
(3) take Ramulus Euonymi (Herba Buchnerae cruciatae), Radix Aconiti Coreani, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) and Radix Semiaquilegiae decontamination, clean, put into container, add 5 times amount soaking in Chinese liquor after 4 hours, add 10 times amount distilled water and decoct 3 hours, extract decoction liquor afterwards；Again add 3 times amount Chinese liquor and 7 times amount distilled water, decoct 2 hours, extract decoction liquor afterwards；Merge 2 decoction liquor, obtain filtrate, filtrate is condensed at 60 DEG C the thick paste of 1.15～1.25 times, drying under reduced pressure, standby；
(4) take Rhizoma Arisaematis, the Rhizoma Pinelliae, Radix Kansui and Azuritum decontamination, after drying, grind into powder in being placed in mortar, cross 200 mesh fine powders, standby；
(5) thick paste of the filtrate obtained by step (1) and the fine powder of step (4) gained, step (2), step (3) gained is mixed, make tablet, be the neurasthenic Chinese medicine composition for the treatment of of the present invention.
Model case
Case 1
Chen, man, 18 years old, due to study anxiety, high two start 2-3 point in morning could fall asleep.All day brain dizziness, memory, attention are poor.After taking two courses for the treatment of of Chinese medicine composition of the embodiment of the present invention 3, all recover normal.
Case 2
Ma, female, 29 years old, because of insomnia, that poor, the fatiguability of spirit comes institute was medical.Patient over 3 years due to work strain, task weight, pressure is big, engender insomnia, show as difficulty falling asleep, need could be fallen asleep for two, three hours, easily wakes up with a start, dreaminess, hypomnesis after sleeping.After taking one course for the treatment of of Chinese medicine composition of the embodiment of the present invention 3, all recover normal.
Case 3
Liu, man, 32 years old, started to have difficulty in going to sleep before 3 years, rely on sleeping pill always.Conscious reaction is more and more blunt, hypomnesis.After taking one course for the treatment of of Chinese medicine composition of the embodiment of the present invention 3, conscious headache, dizziness, alleviate without force phenomenon, recovered natural sleep after taking three courses for the treatment of of Chinese medicine composition of the embodiment of the present invention 3, worked energetic.
Case 4
Zhang, female, 50 years old, housewife, patient felt tired for many years, unable to do what one wishes, dim eyesight tinnitus, bradykinesia, hypomnesis.Over the nearly moon, how tired thing is, and all diseases are increased the weight of, inappetence, sleep not good enough night, and stringy pulse is empty and two chis are puckery.Dialectical for deficient, card belongs to deficiency of both QI and blood, and brain is lost and supported.Controlling suitable benefiting vital QI and blood, brain-strengthening is kept fit.After three courses for the treatment of taking the embodiment of the present invention 3, night sleeps stable, if feeling dizzy mistake, dysfunction of vision and hearing alleviates, and appetite is bestirred oneself, and works energetic.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and without departing from the spirit or essential characteristics of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter from the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is limited by claims rather than described above, it is intended that all changes fallen in the implication of equivalency and scope of claim included in the present invention.
In addition, it is to be understood that, although this specification is been described by according to embodiment, but the most each embodiment only comprises an independent technical scheme, this narrating mode of description is only for clarity sake, description should can also be formed, through appropriately combined, other embodiments that it will be appreciated by those skilled in the art that as an entirety, the technical scheme in each embodiment by those skilled in the art.
Claims (4)
1. prepare the neurasthenic Chinese medicine for the treatment of for one kind, it is characterized in that, in parts by weight, the raw material making this Chinese medicine composition active component is: Caulis Polygoni Multiflori 63～93 parts, Herba Zephyranthis Candidae 60～90 parts, Radix Uncariae rhynchophyllae 58～88 parts, Ramulus Euonymi (Herba Buchnerae cruciatae) 56～86 parts, Rhizoma Arisaematis 53～83 parts, the Rhizoma Pinelliae 48～78 parts, Radix Kansui 45～75 parts, Radix Aconiti Coreani 43～73 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 41～71 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 38～68 parts, fiber crops 36～66 parts, Rhizoma et radix valerianae 34～64 parts, Cladonia fallax Abbayes 32～62 parts, Herba Potentillae Chinensis 28～58 parts, Radix Semiaquilegiae 27～57 parts and Azuritum 22～52 parts.
Chinese medicine composition the most according to claim 1 treats neurasthenic Chinese medicine in preparation, it is characterized in that, in parts by weight, the raw material making this Chinese medicine composition active component is: Caulis Polygoni Multiflori 85 parts, Herba Zephyranthis Candidae 82 parts, Radix Uncariae rhynchophyllae 80 parts, Ramulus Euonymi (Herba Buchnerae cruciatae) 78 parts, Rhizoma Arisaematis 75 parts, the Rhizoma Pinelliae 70 parts, Radix Kansui 68 parts, Radix Aconiti Coreani 65 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 64 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 60 parts, fiber crops 58 parts, Rhizoma et radix valerianae 56 parts, Cladonia fallax Abbayes 55 parts, Herba Potentillae Chinensis 51 parts, Radix Semiaquilegiae 50 parts and Azuritum 45 parts.
Chinese medicine composition the most according to claim 1 treats neurasthenic Chinese medicine in preparation, it is characterized in that, in parts by weight, the raw material making this Chinese medicine composition active component is: Caulis Polygoni Multiflori 77 parts, Herba Zephyranthis Candidae 75 parts, Radix Uncariae rhynchophyllae 73 parts, Ramulus Euonymi (Herba Buchnerae cruciatae) 71 parts, Rhizoma Arisaematis 68 parts, the Rhizoma Pinelliae 63 parts, Radix Kansui 59 parts, Radix Aconiti Coreani 58 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 57 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 53 parts, fiber crops 49 parts, Rhizoma et radix valerianae 49 parts, Cladonia fallax Abbayes 48 parts, Herba Potentillae Chinensis 44 parts, Radix Semiaquilegiae 43 parts and Azuritum 38 parts.
Chinese medicine composition the most according to claim 1 treats neurasthenic Chinese medicine in preparation, it is characterized in that, in parts by weight, the raw material making this Chinese medicine composition active component is: Caulis Polygoni Multiflori 70 parts, Herba Zephyranthis Candidae 67 parts, Radix Uncariae rhynchophyllae 66 parts, Ramulus Euonymi (Herba Buchnerae cruciatae) 64 parts, Rhizoma Arisaematis 61 parts, the Rhizoma Pinelliae 56 parts, Radix Kansui 53 parts, Radix Aconiti Coreani 51 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 49 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 46 parts, fiber crops 44 parts, Rhizoma et radix valerianae 42 parts, Cladonia fallax Abbayes 40 parts, Herba Potentillae Chinensis 36 parts, Radix Semiaquilegiae 36 parts and Azuritum 31 parts.
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| CN104147284A (en) * | 2014-08-29 | 2014-11-19 | 徐蕾 | Chinese herbal preparation for treating epilepsy and preparation method thereof |
| CN104739969A (en) * | 2015-04-25 | 2015-07-01 | 李万青 | Traditional Chinese medicine composition for treating neurasthenia |
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| CN104739969A (en) * | 2015-04-25 | 2015-07-01 | 李万青 | Traditional Chinese medicine composition for treating neurasthenia |
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