CN105878307A - Soft capsule with seabuckthorn seed oil and method for preparing soft capsule - Google Patents
Soft capsule with seabuckthorn seed oil and method for preparing soft capsule Download PDFInfo
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- CN105878307A CN105878307A CN201610272461.3A CN201610272461A CN105878307A CN 105878307 A CN105878307 A CN 105878307A CN 201610272461 A CN201610272461 A CN 201610272461A CN 105878307 A CN105878307 A CN 105878307A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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Abstract
The invention relates to a soft capsule with seabuckthorn seed oil. The soft capsule comprises a capsule shell and contents inside the capsule shell, and is characterized in that the thickness of the capsule shell is 0.75-0.80 mm, the weight of the contents is 0.8-1.2 g/capsule, and the contents comprise the seabuckthorn seed oil. A method for preparing the soft capsule includes three steps of (1), preparing the contents; (2), preparing the capsule shell; (3), pelleting, shaping, cleaning and drying the contents and the capsule shell and selecting capsules to obtain the soft capsule. Compared with the prior art, the soft capsule and the method have the advantages that raw materials for the soft capsule are simple and are easily available, technologies for manufacturing the soft capsule are simple, and excellent effects of protecting livers can be realized; the soft capsule is mild in property, free of toxic and side effects and suitable for all people suffering from liver injury.
Description
Technical field
The present invention relates to a kind of health-related capsule, be specifically related to a kind of Fructrs Hippophae seed oil soft capsule and preparation method thereof.
Background technology
The damage that chemical liver injury is i.e. caused by chemical Hepatoxic substance.These chemical substances include ethanol,
Chemical toxicant in environment and some drugs.As the liver of body weight for humans organ to be detoxified, there is Hepatic artery regulating liver-QI quiet
Arteries and veins double blood supply.Chemical substance can be recycled into liver by gastrointestinal tract portal vein or body and convert, therefore
The toxicant infringement that liver is easily subject in chemicals.It is wherein most widely ethanol to human liver health effect,
In daily life, due to various reasons, people can inevitably drink, as on New Year's Day or other festivals, the birthday gather
Meeting, business entertainment etc., long-term excessive drinking not only affects people's mental status but also can cause liver in various degree
Damage.
Chemical liver injury causes liver to lose normal physiological function.And liver is as human energy metabolism
With the vitals of human detoxification, on the one hand ensure that all of toxin decomposition entering in human body is normal, toxin expelling is normal,
When chemical contamination toxin various in blood can not be decomposed discharge through liver, and various pollutions are transported to along with blood
Each cell of whole body, each cell long-period eats these pollution toxin and will result in cytometaplasia, here it is we say
Sudden change, namely cancer；On the other hand liver is responsible for the energy metabolism of human body, when energy can not be by liver metabolism
Becoming the nutrient substance required for cell, these energy just can only stop in blood, define high protein, hyperglycemia,
Hyperlipidemia.Because polluting and causing hepatic injury, the various chronic diseases caused because of hepatic injury again and the generation of cancer.
Prevention chemical liver injury is the big problem being related to the life-span.
Along with improving constantly of living standards of the people, health is increasingly paid attention to by people, and increasing people passes through
Supplement in good time some targetedly health product protect self liver function, to reach the health secured good health, because of
This this product has certain market demand.
Summary of the invention
Defect that the purpose of the present invention is contemplated to overcome above-mentioned prior art to exist and providing a kind of easily absorbs, safety
Effectively, Fructrs Hippophae seed oil soft capsule that chemical liver injury is had auxiliary protection function and preparation method thereof.
The purpose of the present invention can be achieved through the following technical solutions: a kind of Fructrs Hippophae seed oil soft capsule, this soft capsule
Including capsule shell and be loaded on the content within capsule shell, the thickness of described capsule shell be 0.75mm～
0.80mm, the weight of described content is 0.8～1.2g/ grain, and content includes Fructrs Hippophae seed oil.
Containing alpha-linolenic acid in described Fructrs Hippophae seed oil, it has been investigated that, alpha-linolenic acid has good hepatoprotective
Effect.
Fructrs Hippophae seed oil extracts from seed of Fructus Hippophae, rich in there being fatsoluble vitamin E, it is necessary to fatty acid Asia oil
Acid and alpha-linolenic acid, the bioactive substance such as flavonoid, chemical liver injury there is is auxiliary protection function.Through little
Mus experiment shows: the hepatic injury that CCl4 is caused by Fructrs Hippophae seed oil has obvious protective function, and its effective dose is 0.5
G/kg body weight；The acute liver damage that ethanol is caused by Fructrs Hippophae seed oil has obvious protective function, and its effective dose is
0.333g/kg.bw；Fructrs Hippophae seed oil has certain protective effect to mouse experiment liver cirrhosis；Fructrs Hippophae seed oil pair
Caused by CCl4, rat liver fibrosis has certain protective role；Fructrs Hippophae seed oil can be substantially to anti-mouse and rat chemical
The rising of liver MDA caused by hepatic injury (CCI, acetaminophen and ethanol), and SGPT and SGOT can be reduced
Vigor, stops the exhaustion of acetaminophen poisoning mice liver GSH；Both Oleum Hippophae and oleanolic acid drug combination pair
Sc carbon tetrachloride and diet add Adeps Sus domestica, solid liquor-saturated, the Liver Damage in Rats of ethanol duplication of gallbladder, all has in various degree
Alleviate effect, and can SGPT, gamma Globulin, malonaldehyde, the rising of hydroxyproline in anti-hemostasis；And Fructus Hippophae
Seed oil will not make mice produce obvious damage pathological change.Therefore, this product consumption 1000g/1000 grain, every day
2 times, each 2, i.e. 4g/d, is safe and reliable.
Described capsule shell includes gelatin, G & W, and described gelatin, the weight ratio of G & W are 1:
(0.3～0.6): 1, preferably 1: 0.35: 1.
The present invention have selected soft capsule in dosage form, and soft capsule has internal utilization rate, absorbance height, and content is equal
One property is good, and content deviation is the lowest, can hide some content abnormal flavour, can prevent the features such as air oxidation, be suitable to
While daily house is edible, be more suitable for people be away on a vacation, edible when travelling.
It is the feature of soft capsule with elasticity that cyst wall has plasticity strong, is also the basis of soft capsule molding, it by
Gelatin, glycerol (plasticizer) and pure water three are constituted, and its part by weight is typically gelatin: glycerol (plasticising
Agent): pure water=1: (0.3～0.6): 1.If measuring too low (or too high), then cyst wall with glycerol (plasticizer)
Meeting (or the softest) really up to the mark, owing to being only the loss of moisture content in the preparation of soft capsule and in placement process,
Therefore, gelatin has highly important impact with the ratio of glycerol (plasticizer) to preparation and the quality of soft capsule,
Selecting the optimal ratio of gelatin and glycerol (plasticizer) according to this product feature, done screening test, result is as follows
Table:
| Gelatin: glycerol: pure water | Capsule shells soft durometer |
| 1:0.3:1 | Tangible, the most firmly |
| 1:0.35:1 | Tangible, neither too hard, nor too soft |
| 1:0.4:1 | The softest, rubber is adhered a bit |
| 1:0.45:1 | Soft, rubber is adhered, has a little deformation |
From above-mentioned result of the test, soft capsule pelletization quality is relevant with glycerol (plasticizer) consumption, therefore this product
Product formula determines gelatin: glycerol: the optimum ratio of pure water is 1: 0.35: 1.
A kind of preparation method of such as above-mentioned Fructrs Hippophae seed oil soft capsule, including following step:
(1) weigh Fructrs Hippophae seed oil, be filtrated to get content stand-by；
(2) weigh water and glycerol in proportion, be stirred and heated to 70～80 DEG C, add gelatin, at 60～70 DEG C
At a temperature of stirring and dissolving 30～45min, after gelatin is completely dissolved, by gained solution evacuation, until solution
Bubble-free, then filters, and insulation 2～6h i.e. obtains glue at a temperature of 50～65 DEG C, stand-by；
(3) step (1) gained content and step (2) gained glue are placed in soft capsule pellet processing machine compacting
Pelletization, then shapes in drying machine rolling cage, cleans with 95% edible ethanol, be then dried, select ball to obtain sand
Spine soft capsule of glossy ganoderma.
The vacuum of step (2) described evacuation is-0.05～-0.1MPa, and the pumpdown time is 20～30min.
The rotating speed 2.5～4 turns/min of step (3) described soft capsule pellet processing machine, sprinkler body temperature 40～50 DEG C；
The time of described sizing is 2～3h hour, and the temperature of sizing is 18～26 DEG C, relative humidity during sizing
It is 40%～50%；
Described dry temperature is 20～35 DEG C, relative humidity≤35% when being dried, the time 10h being dried；
Described select ball for picking abnormity ball, big piller, bubble ball, heterochromatic ball, leakage of oil ball and twins ball.
During soft capsule pelleting, need the soft gelatin capsule pressed to be shaped, to ensure the face shaping of soft gelatin capsule.This
Product carries out soft capsule sizing under conditions of ambient temperature 18-26 DEG C, relative humidity 40～50%.In sizing
During to affect the principal element of soft gelatin capsule fixed effect be shaping time.Also its time is done when determining sizing parameter
Experiment sieving:
In terms of shaping time with soft gelatin capsule situation, the short sizing of shaping time is the most intact, and shaping time is long, shape intact but
Waste resource, admittedly selecting most suitable shaping time is 2～3h.
Compared with prior art, beneficial effects of the present invention is embodied in following several respects:
(1) present invention is raw materials used the easiest, and manufacturing process is simple, can reach the level of domestic like product,
And there is the effect of good hepatoprotective；
(2) performance of the present invention is gentle, will not produce toxic and side effects, the most all hepatic injury crowds.
Accompanying drawing explanation
Fig. 1 is the process flow diagram of the present invention of the present invention.
Detailed description of the invention
Elaborating embodiments of the invention below, the present embodiment enters under premised on technical solution of the present invention
Row is implemented, and gives detailed embodiment and concrete operating process, but under protection scope of the present invention is not limited to
The embodiment stated.
Embodiment 1
A kind of Fructrs Hippophae seed oil soft capsule, this soft capsule includes capsule shell and is placed in the content within capsule shell,
The thickness of capsule shell is 0.75mm, and the weight of content is 1000mg/ grain, and content includes Fructrs Hippophae seed oil.
Wherein, containing alpha-linolenic acid in Fructrs Hippophae seed oil, the content of described alpha-linolenic acid is (waiting to supplement), seed of Fructus Hippophae
Oil is to extract by the following method to obtain (waiting to supplement):
Capsule shell is mixed to get by gelatin, G & W, and gelatin, the weight ratio of G & W are 1:0.35:1.
Above-mentioned Fructus Hippophae soft capsule of glossy ganoderma through the following steps that prepared, the technological process of preparation as shown in Figure 1:
(1) choose Fructrs Hippophae seed oil, it is tested, weigh Fructrs Hippophae seed oil the most in proportion, and use
120 mesh sock filtration, obtain content stand-by；
(2) choose pure water and glycerol, it tested, weigh water and glycerol the most in proportion,
Heated and stirred, to 75 DEG C, adds and checks qualified and load weighted gelatin, stirring and dissolving 40min at a temperature of 65 DEG C,
After gelatinization glue, by gained solution evacuation, evacuation 25min under-0.08MPa vacuum, until solution
Bubble-free, then filters, and standing insulation 4h i.e. obtains glue at a temperature of 60 DEG C, stand-by；
(3) step (1) gained content and step (2) gained glue are placed in pelleting in soft capsule pellet processing machine,
The rotating speed 2.5～4 turns/min of soft capsule pellet processing machine, sprinkler body temperature 40～50 DEG C；Then decided at the higher level but not officially announced at drying machine rolling cage
Type, the time of sizing is 2～3h hour, and the temperature of sizing is 18～26 DEG C, relative humidity during sizing be 40%～
50%；Then carry out washing ball with 95% edible ethanol, then pill be dried, be dried temperature be 20～
35 DEG C, relative humidity≤35% when being dried, the time 10h being dried；Finally carry out selecting ball, pick abnormity ball,
Big piller, bubble ball, heterochromatic ball, leakage of oil ball and twins ball, finally give Fructus Hippophae soft capsule of glossy ganoderma.
Fructrs Hippophae seed oil soft capsule made to the present embodiment carries out chemical liver injury has assistant protection function to test, animal
Using cleaning agent ICR female mice, 3 dosage group mices are given not by 10mL/kg body weight per os gavage every day
With the tested material of concentration, solvent control group and model control group give equivalent edible vegetable oil, continuous 30 days, dynamic
Thing is weighed weekly twice, and to regulate tested material dosage, free diet is drunk water.In testing the 30th day by each treated animal
Weighing, model group and each dosage treated animal give 50% (v/v) ethanol by the disposable gavage of 0.012mL/g BW
Contamination, flux matched group gives distilled water, fasting, after 16 hours, takes part hepatic tissue, homogenate, measures liver
TG, GSH, MDA content in tissue, takes liver simultaneously and carries out histopathological examination.
Result of the test shows, per os gavage gives the Fructrs Hippophae seed oil soft capsule of mice various dose, all can suppress low,
The rising of TG content in 16th hour hepatic tissue after middle and high 3 dosage group chmice acute alcoholic hepatic injuries,
Raise the content of high dose group mice GSH；Hepatic pathology checks that result shows: low, the fat of high dose group animal
Drop in the distribution of liver, scope and area total score less than ethanol model matched group.Therefore show: this Fructrs Hippophae seed oil is soft
Capsule has assistant protection function effect to chemical liver injury.
According to " health food inspection and assessment technique specification " (Ministry of Public Health 2003), the present embodiment Fructus Hippophae Ganoderma is soft
Capsule has the function of enhancing immunity.
Embodiment 2
A kind of Fructrs Hippophae seed oil soft capsule, this soft capsule includes capsule shell and is placed in the content within capsule shell,
The thickness of capsule shell is 0.75mm, and the weight of content is 800mg/ grain, and content is Fructrs Hippophae seed oil, this glue
Capsule shell is made up of gelatin, G & W, and gelatin, the weight ratio of G & W are 1:0.3:1.
The production technology of this Fructrs Hippophae seed oil soft capsule is similar to Example 1, and difference is:
(1) weigh Fructrs Hippophae seed oil, with sock filtration, obtain content stand-by；
(2) weigh water and glycerol in proportion, be stirred and heated to 70 DEG C, add gelatin, at a temperature of 60 DEG C
Stirring and dissolving 30min, after gelatin is completely dissolved, by gained solution evacuation 20min, until vacuum is
-0.05MPa, until solution bubble-free, then filters, and insulation 6h i.e. obtains glue at a temperature of 50 DEG C, stand-by；
(3) step (1) gained content and step (2) gained glue are placed in soft capsule pellet processing machine compacting
Pelletization, the 2.5 turns/min of rotating speed of pellet processing machine, sprinkler body temperature 40 DEG C, then shape in drying machine rolling cage, sizing
Time be 2h hour, the temperature of sizing is 18 DEG C, and relative humidity during sizing is 40%；Use 95% edible wine
Seminal plasma is washed, and is then dried, and the temperature being dried is 20 DEG C, relative humidity≤35% when being dried, the time being dried
10h；Pick abnormity ball, big piller, bubble ball, heterochromatic ball, leakage of oil ball and twins ball and obtain Fructrs Hippophae seed oil
Soft capsule.
Embodiment 3
A kind of Fructrs Hippophae seed oil soft capsule, this soft capsule includes capsule shell and is placed in the content within capsule shell,
The thickness of capsule shell is 0.8mm, and the weight of content is 1200mg/ grain, and content is Fructrs Hippophae seed oil, this glue
Capsule shell is made up of gelatin, G & W, and gelatin, the weight ratio of G & W are 1:0.6:1.
The production technology of this Fructrs Hippophae seed oil soft capsule is similar to Example 1, and difference is:
(1) weigh Fructrs Hippophae seed oil, with sock filtration, obtain content stand-by；
(2) weigh water and glycerol in proportion, be stirred and heated to 80 DEG C, add gelatin, at a temperature of 70 DEG C
Stirring and dissolving 45min, after gelatin is completely dissolved, by gained solution evacuation 30min, until vacuum is
-0.1MPa, until solution bubble-free, then filters, and insulation 2h i.e. obtains glue at a temperature of 65 DEG C, stand-by；
(3) step (1) gained content and step (2) gained glue are placed in soft capsule pellet processing machine compacting
Pelletization, the 4 turns/min of rotating speed of pellet processing machine, sprinkler body temperature 50 C, then shape in drying machine rolling cage, sizing
Time be 3h hour, the temperature of sizing is 26 DEG C, and relative humidity during sizing is 50%；Use 95% edible wine
Seminal plasma is washed, and is then dried, and the temperature being dried is 35 DEG C, relative humidity≤35% when being dried, the time being dried
10h；Pick abnormity ball, big piller, bubble ball, heterochromatic ball, leakage of oil ball and twins ball and obtain Fructrs Hippophae seed oil
Soft capsule.
Claims (7)
1. a Fructrs Hippophae seed oil soft capsule, this soft capsule includes capsule shell and is loaded on the content within capsule shell, it is characterised in that the thickness of described capsule shell is 0.75mm～0.80mm, the weight of described content is 0.8～1.2g/ grain, and content includes Fructrs Hippophae seed oil.
A kind of Fructrs Hippophae seed oil soft capsule the most according to claim 1, it is characterised in that containing alpha-linolenic acid in described Fructrs Hippophae seed oil.
A kind of Fructrs Hippophae seed oil soft capsule the most according to claim 1, it is characterised in that described capsule shell includes gelatin, G & W, and described gelatin, the weight ratio of G & W are 1: (0.3～0.6): 1.
A kind of Fructrs Hippophae seed oil soft capsule the most according to claim 3, it is characterised in that described capsule shell includes gelatin, G & W, and described gelatin, the weight ratio of G & W are 1: 0.35: 1.
5. the preparation method of Fructrs Hippophae seed oil soft capsule as described in Claims 1 to 4 is arbitrary, it is characterised in that this preparation method includes following step:
(1) weigh Fructrs Hippophae seed oil, be filtrated to get content stand-by；
(2) water and glycerol are weighed in proportion, it is stirred and heated to 70～80 DEG C, add gelatin, stirring and dissolving 30～45min at a temperature of 60～70 DEG C, after gelatin is completely dissolved, by gained solution evacuation, until solution bubble-free, then filter, and insulation 2～6h i.e. obtains glue at a temperature of 50～65 DEG C, stand-by；
(3) step (1) gained content and step (2) gained glue are placed in soft capsule pellet processing machine compacting pelletization, then shape in drying machine rolling cage, clean with 95% edible ethanol, be then dried, select ball to obtain Fructus Hippophae soft capsule of glossy ganoderma.
The preparation method of a kind of Fructrs Hippophae seed oil soft capsule the most according to claim 5, it is characterised in that the vacuum of step (2) described evacuation is-0.05～-0.1MPa, the pumpdown time is 20～30min.
The preparation method of a kind of Fructrs Hippophae seed oil soft capsule the most according to claim 5, it is characterised in that the rotating speed 2.5～4 turns/min of step (3) described soft capsule pellet processing machine, sprinkler body temperature 40～50 DEG C；
The time of described sizing is 2～3h hour, and the temperature of sizing is 18～26 DEG C, and relative humidity during sizing is 40%～50%；
Described dry temperature is 20～35 DEG C, relative humidity≤35% when being dried, the time 10h being dried；
Described select ball for picking abnormity ball, big piller, bubble ball, heterochromatic ball, leakage of oil ball and twins ball.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610272461.3A CN105878307A (en) | 2016-04-28 | 2016-04-28 | Soft capsule with seabuckthorn seed oil and method for preparing soft capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610272461.3A CN105878307A (en) | 2016-04-28 | 2016-04-28 | Soft capsule with seabuckthorn seed oil and method for preparing soft capsule |
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| CN201610272461.3A Pending CN105878307A (en) | 2016-04-28 | 2016-04-28 | Soft capsule with seabuckthorn seed oil and method for preparing soft capsule |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107596019A (en) * | 2017-10-20 | 2018-01-19 | 吉林省世龙药业集团有限公司 | A kind of Seabuckthorm Seed Oil soft capsule and preparation method thereof |
| CN107736621A (en) * | 2017-09-22 | 2018-02-27 | 华侨大学 | A kind of setose abelmoschus seed fat capsule and preparation method thereof |
| CN108175101A (en) * | 2018-03-09 | 2018-06-19 | 鄂尔多斯市天骄资源发展有限责任公司 | A kind of sea-buckthorn soft capsule preparation and preparation method thereof |
| CN115251389A (en) * | 2022-06-23 | 2022-11-01 | 南昌蜂芝缘健康科技有限公司 | Ganoderma lucidum spore oil sea-buckthorn soft capsule and preparation method thereof |
| CN116115706A (en) * | 2023-03-01 | 2023-05-16 | 汉中市华瑞牡丹生物科技有限公司 | Sea buckthorn seed oil soft capsule for repairing gastric mucosa and preparation method thereof |
-
2016
- 2016-04-28 CN CN201610272461.3A patent/CN105878307A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107736621A (en) * | 2017-09-22 | 2018-02-27 | 华侨大学 | A kind of setose abelmoschus seed fat capsule and preparation method thereof |
| CN107596019A (en) * | 2017-10-20 | 2018-01-19 | 吉林省世龙药业集团有限公司 | A kind of Seabuckthorm Seed Oil soft capsule and preparation method thereof |
| CN108175101A (en) * | 2018-03-09 | 2018-06-19 | 鄂尔多斯市天骄资源发展有限责任公司 | A kind of sea-buckthorn soft capsule preparation and preparation method thereof |
| CN115251389A (en) * | 2022-06-23 | 2022-11-01 | 南昌蜂芝缘健康科技有限公司 | Ganoderma lucidum spore oil sea-buckthorn soft capsule and preparation method thereof |
| CN116115706A (en) * | 2023-03-01 | 2023-05-16 | 汉中市华瑞牡丹生物科技有限公司 | Sea buckthorn seed oil soft capsule for repairing gastric mucosa and preparation method thereof |
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