CN105873936B - 线粒体靶向的二羰基螯合化合物 - Google Patents

线粒体靶向的二羰基螯合化合物 Download PDF

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Publication number
CN105873936B
CN105873936B CN201480063625.0A CN201480063625A CN105873936B CN 105873936 B CN105873936 B CN 105873936B CN 201480063625 A CN201480063625 A CN 201480063625A CN 105873936 B CN105873936 B CN 105873936B
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formula
alkyl
mitog
compound
alkylidene
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Expired - Fee Related
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CN201480063625.0A
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English (en)
Chinese (zh)
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CN105873936A (zh
Inventor
迈克尔·帕特里克·墨菲
罗宾·安德鲁·詹姆斯·史密斯
理查德·查理·哈特利
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United Kingdom Research and Innovation
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Medical Research Council
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Dentistry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CN201480063625.0A 2013-11-22 2014-11-21 线粒体靶向的二羰基螯合化合物 Expired - Fee Related CN105873936B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1320636.2 2013-11-22
GBGB1320636.2A GB201320636D0 (en) 2013-11-22 2013-11-22 Compounds
PCT/EP2014/075323 WO2015075200A1 (en) 2013-11-22 2014-11-21 Mitochondria-targeted dicarbonyl sequestering compounds

Publications (2)

Publication Number Publication Date
CN105873936A CN105873936A (zh) 2016-08-17
CN105873936B true CN105873936B (zh) 2018-09-14

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CN201480063625.0A Expired - Fee Related CN105873936B (zh) 2013-11-22 2014-11-21 线粒体靶向的二羰基螯合化合物

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Country Link
US (1) US9963474B2 (cg-RX-API-DMAC7.html)
EP (2) EP3071582B1 (cg-RX-API-DMAC7.html)
JP (1) JP6661533B2 (cg-RX-API-DMAC7.html)
CN (1) CN105873936B (cg-RX-API-DMAC7.html)
AU (1) AU2014351802B2 (cg-RX-API-DMAC7.html)
CA (1) CA2931000A1 (cg-RX-API-DMAC7.html)
ES (1) ES2802123T3 (cg-RX-API-DMAC7.html)
GB (1) GB201320636D0 (cg-RX-API-DMAC7.html)
HK (1) HK1226079A1 (cg-RX-API-DMAC7.html)
SG (2) SG11201603485TA (cg-RX-API-DMAC7.html)
WO (1) WO2015075200A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201603129B (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3562830B1 (en) * 2016-12-29 2023-06-07 Universidade do Porto Hydroxybenzoic acid derivatives, methods and uses thereof
JP6985730B2 (ja) * 2017-11-17 2021-12-22 株式会社日立ハイテクサイエンス 試料分析システム、表示方法及び試料分析方法
KR101920902B1 (ko) * 2017-12-27 2018-11-21 전남대학교 산학협력단 심혈관 질환 조기진단 pet 조영용 화합물 및 그의 용도
WO2020036329A1 (ko) * 2018-08-16 2020-02-20 숙명여자대학교산학협력단 미토콘드리아 내 nad(p)h 검출을 위한 형광 프로브 및 이를 이용한 검출방법
WO2020154731A1 (en) * 2019-01-25 2020-07-30 Mti Biotech, Inc. Triphenylphosphonium-tethered salicylamine derivatives
BR112021014696A2 (pt) 2019-01-25 2021-12-28 Univ Vanderbilt Sequestrantes isocetais/de isolevuglandina que têm mitocôndria como alvo
KR102596981B1 (ko) * 2019-10-30 2023-10-31 주식회사 퓨전바이오텍 미토콘드리아 표적 화합물 및 이를 포함하는 노화 관련 질환의 치료 또는 예방을 위한 조성물
CA3169467A1 (en) * 2020-01-27 2021-08-05 Sergey I. Dikalov Mitochondria-targeted isoketal/isolevuglandin scavengers and uses thereof

Citations (3)

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Publication number Priority date Publication date Assignee Title
GB926998A (en) * 1960-04-25 1963-05-22 Ici Ltd New water-soluble azo dyestuffs containing phosphonium groups
US6419711B1 (en) * 1998-03-20 2002-07-16 L'oreal Oxidation dyeing compositions containing a cationic coupling agent, novel cationic coupling agents
CN102617467A (zh) * 2012-02-21 2012-08-01 大连理工大学 一种检测一氧化氮的超高灵敏荧光探针

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JPS52806A (en) 1975-02-20 1977-01-06 Dai Ichi Kogyo Seiyaku Co Ltd Preparation of ester
JPS6029391B2 (ja) 1976-02-04 1985-07-10 富士写真フイルム株式会社 ベンゾトリアゾ−ル化合物
FR2776290B1 (fr) * 1998-03-20 2001-08-10 Oreal Nouveaux composes cationiques, leur utilisation comme coupleurs pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture
FR2788520B1 (fr) * 1999-01-19 2003-02-28 Oreal Nouveaux colorants mono-benzeniques cationiques, leur utilisation pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture
CA2431635A1 (en) * 2001-01-23 2002-08-01 P&G-Clairol, Inc. Couplers for oxidative coloration of hair
CN1678285A (zh) * 2002-09-02 2005-10-05 西巴特殊化学品控股有限公司 多孔材料的染色方法
EP1818063A1 (en) * 2004-12-02 2007-08-15 Japan Science and Technology Agency Medicine for treatment of disease caused by hyperstimulatory cytotoxicity and therapeutic method
US7956193B2 (en) 2007-05-04 2011-06-07 University Of South Florida Intramolecular C-H amination with sulfonyl azides
US8466140B2 (en) 2007-09-10 2013-06-18 University Of Massachusetts Mitochondria-targeted anti-tumor agents
FR2984321A1 (fr) * 2011-12-16 2013-06-21 Oreal Paraphenylenediamines cationiques, composition comprenant au moins de tels composes, procede de mise en oeuvre et utilisation
FR2996552B1 (fr) * 2012-08-17 2016-10-14 Oreal Composition tinctoriale comprenant un derive o-alkyle substitue de meta-phenylenediamine cationique

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB926998A (en) * 1960-04-25 1963-05-22 Ici Ltd New water-soluble azo dyestuffs containing phosphonium groups
US6419711B1 (en) * 1998-03-20 2002-07-16 L'oreal Oxidation dyeing compositions containing a cationic coupling agent, novel cationic coupling agents
CN102617467A (zh) * 2012-02-21 2012-08-01 大连理工大学 一种检测一氧化氮的超高灵敏荧光探针

Non-Patent Citations (5)

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A mitochondria-targeted mass spectrometry probe to detect glyoxals:implications for diabetes;Pamela Boon Li Pun et al.;《Free Radical Biology&Medicine》;20131204;第437-450页 *
Novel aromatic polyimides with pendent triphenylamine units: Synthesis,photophysical, electrochromic properties;Kun Zhang et al.;《Journal of Electroanalytical Chemistry》;20120716;第101-109页 *
Pathological Significance ofMitochondrial Glycation;Pamela Boon Li Pun et al.;《International Journal of Cell Biology》;20120101;第231-13页 *
Pathological Significance ofMitochondrial Glycation;Robin A.J. Smith et al.;《Trends in Pharmacological Sciences》;20120630;第341-352页 *
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes;Kristine M. Robinson et al.;《Proceedings of Hte National Academy of Sciences》;20061010;第15038-15043页 *

Also Published As

Publication number Publication date
NZ719705A (en) 2021-09-24
AU2014351802B2 (en) 2019-10-03
SG11201603485TA (en) 2016-05-30
JP2017504561A (ja) 2017-02-09
JP6661533B2 (ja) 2020-03-11
ES2802123T3 (es) 2021-01-15
ZA201603129B (en) 2018-12-19
WO2015075200A1 (en) 2015-05-28
HK1226079A1 (zh) 2017-09-22
US20160289252A1 (en) 2016-10-06
CN105873936A (zh) 2016-08-17
EP3071582A1 (en) 2016-09-28
AU2014351802A1 (en) 2016-05-26
US9963474B2 (en) 2018-05-08
EP3071582B1 (en) 2020-04-29
CA2931000A1 (en) 2015-05-28
EP3623375A1 (en) 2020-03-18
GB201320636D0 (en) 2014-01-08
SG10201807904RA (en) 2018-10-30

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