CN105854068A - Sodium alginate nanofiber surgical dressing containing traditional Chinese medicine antibiotic component berberine and preparation method thereof - Google Patents
Sodium alginate nanofiber surgical dressing containing traditional Chinese medicine antibiotic component berberine and preparation method thereof Download PDFInfo
- Publication number
- CN105854068A CN105854068A CN201510029654.1A CN201510029654A CN105854068A CN 105854068 A CN105854068 A CN 105854068A CN 201510029654 A CN201510029654 A CN 201510029654A CN 105854068 A CN105854068 A CN 105854068A
- Authority
- CN
- China
- Prior art keywords
- sodium alginate
- chinese medicine
- berberine
- preparation
- electrostatic spinning
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Artificial Filaments (AREA)
Abstract
The invention discloses a sodium alginate nanofiber surgical dressing containing a traditional Chinese medicine antibiotic component berberine. The sodium alginate nanofiber surgical dressing is prepared by sodium alginate, polyving akohol and the traditional Chinese medicine antibiotic component berberine by an electrostatic spinning method; wherein the proportion of a sodium alginate solution to a polyving akohol solution in an electrostatic spinning solution is 4:6-5:5, and content of berberine accounts for 3-6wt% of that of sodium alginate and polyving akohol. Due to no addition of harmful substances such as a strong non-polar solution during a preparation method of the surgical dressing, the used berberine is safe and harmless, bacteria cannot generate drug resistance, the sodium alginate nanofiber surgical dressing containing the traditional Chinese medicine antibiotic component berberine has the advantages of safe and reliable usage and high efficiency bacterinertness, and has escherichia coli antibacterial rate being 92.9-97.1%.
Description
Technical field
The invention belongs to polymeric material field, particularly relate to a kind of sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial composition and preparation method thereof.
Background technology
Sodium alginate is a kind of natural polysaccharide mostling come from algae, is mainly made up of Isosorbide-5-Nitrae-beta-D-mannuronic acid (M unit) and α-L-guluronic acid (G unit), similar to the protein-polysaccharide composition in human body cell epimatrix；Sodium alginate also has that source is wide, good biocompatibility, have the good characteristics such as controlled biological degradability and nonhazardous and will not cause antigen-reactive；These characteristics make it have huge application potential in medical dressing field.
The main component proteoglycan (Fructus Vitis viniferae ammonia polysaccharide (GAG)) of the natural extracellular matrix in tissue and fibrin all have nanostructured composition；Research shows that nanostructured medical material contributes to cell adhesion and propagation, and function is higher than micro-meter scale, and therefore, nanofiber has higher value in medical dressing field；The main method preparing nanofiber at present is electrostatic spinning；But owing to sodium alginate is a kind of anionic polyelectrolyte, its strand is in aqueous in rigidity and there is vermiform to extend, and pure sodium alginate Static Spinning is extremely difficult.
Wound infection is the key factor affecting wound healing, is also the major reason causing patient wound the most dead；Accordingly, as good medical dressing, should have preferable anti-microbial property；Conventional medical dressing, in order to obtain anti-microbial property, is usually and adds a certain amount of antibiotic in medical dressing, or have the metal ion such as nanometer silver etc. of anti-microbial property；But, if using antibiotic pathogenic bacteria can be made to morph and produce drug resistance for a long time, metallic, also due to major part is all heavy metal, has potential hazard to human organ during use.
Summary of the invention
The invention aims to solve above-mentioned technical problem and provide a kind of sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial ingredient berberine；This material is prepared from by electrostatic spinning means by sodium alginate, polyvinyl alcohol and Chinese medicine antibacterial ingredient berberine.In its blend spinning liquid, the ratio of sodium alginate soln and poly-vinyl alcohol solution is 4:6-5:5, the content of Chinese medicine antibacterial ingredient berberine is sodium alginate and the 3wt%-6wt% of polyvinyl alcohol quality, final prepare containing Chinese medicine antibacterial composition sodium alginate nano fiber medical dressing colibacillary bacteriostasis rate is reached 92.9%-97.1%.
The present invention takes techniques below scheme for achieving the above object: prepares the sodium alginate soln of certain mass mark and poly-vinyl alcohol solution and is mixed and added into the NaCl of surfactant TX-100 and 0.5wt% of 0.5wt%-2wt% with the ratio of 4:6-5:5 and mixs homogeneously with agitator stirring 2h, then adds the Chinese medicine antibacterial ingredient berberine of the 3wt%-6wt% of sodium alginate, polyvinyl alcohol quality and stirs 6h and be prepared as spinning liquid；Inject in needle tubing after the spinning liquid of mix homogeneously is stood froth breaking 24h, utilize electrostatic spinning apparatus carry out electrostatic spinning and prepare the sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial composition.
The concrete preparation method of the present invention is:
(1) preparation of sodium alginate soln: sodium alginate is dissolved in deionized water and stirs 2h at normal temperatures and prepare the sodium alginate soln that mass fraction is 3wt%.
(2) preparation of poly-vinyl alcohol solution: it is the poly-vinyl alcohol solution of 10wt% that a certain amount of polyvinyl alcohol is dissolved in deionized water stirring 4h acquisition mass fraction under conditions of 90 DEG C.
(3) preparation of electrostatic spinning liquid: with the ratio of 4:6-5:5, the poly-vinyl alcohol solution of the sodium alginate soln of 3wt% and 10wt% being mixed NaCl stirring 2h that is mixed and that add the mass fraction TX-100 and 0.5wt% as 0.5wt%-2wt% and mixs homogeneously, the Chinese medicine antibacterial ingredient berberine stirring 6h the discontinuous degassing that then add the 3wt%-6wt% of sodium alginate, polyvinyl alcohol quality obtain electrostatic spinning solution.
(4) preparation of nano fibrous membrane: injected by electrostatic spinning solution in the needle tubing of electrostatic spinning apparatus, regulation voltage is 12-25kV, and the distance of shower nozzle to receptor is 5-20cm, and flow is 0.1-1.5ml/h；Open device for spinning, the sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial ingredient berberine can be collected on the receiver.
Advantages of the present invention is: polyvinyl alcohol is a kind of water-soluble macromolecule polymer nontoxic, degradable, has preferable chain entanglement degree at aqueous solution, can be prepared by electrostatic spinning, is a kind of conventional medical material；TX-100 is a kind of nontoxic nonionic type surfactant by U.S. FDA certification, by by sodium alginate and polyvinyl alcohol, under the effect of TX-100 and NaCl, the electrostatic spinning of sodium alginate is achieved under conditions of with deionized water as solvent, and improve the ratio of sodium alginate soln to 50%, the feature that the sodium alginate nano fiber dressing of preparation has environmental protection, nontoxic and sodium alginate content is high；Chinese medicine antibacterial ingredient berberine is the plant essence extracted from natural Chinese medicinal herb, not only there is preferable antibiotic property, and compared with antibiotic and metal ion antibacterial agent, both antibacterial will not have been made to produce drug resistance, also human body will not be caused potential hazard, the sodium alginate nano fiber medical dressing that berberine is mixed in sodium alginate/poly-vinyl alcohol solution preparation is not respectively provided with high-efficiency antimicrobial, and safety.
Detailed description of the invention
Embodiment
1
(1) preparation of sodium alginate soln: sodium alginate is dissolved in deionized water and stirs 2h at normal temperatures and prepare the sodium alginate soln that mass fraction is 3wt%.
(2) preparation of poly-vinyl alcohol solution: it is the poly-vinyl alcohol solution of 10wt% that a certain amount of polyvinyl alcohol is dissolved in deionized water stirring 4h acquisition mass fraction under conditions of 90 DEG C.
(3) preparation of electrostatic spinning liquid: with the ratio of 4:6, the poly-vinyl alcohol solution of the sodium alginate soln of 3wt% and 10wt% being mixed NaCl stirring 2h that is mixed and that add the mass fraction TX-100 and 0.5wt% as 0.5wt%% and mixs homogeneously, the Chinese medicine antibacterial ingredient berberine stirring 6h the discontinuous degassing that then add the 3wt% of sodium alginate, polyvinyl alcohol quality obtain electrostatic spinning solution.
(4) preparation of nano fibrous membrane: injected by electrostatic spinning solution in the needle tubing of electrostatic spinning apparatus, regulation voltage is 16kV, and the distance of shower nozzle to receptor is 18cm, and flow is 0.8ml/h；Open device for spinning, the sodium alginate nano fiber medical dressing containing 3wt% Chinese medicine antibacterial ingredient berberine can be collected on the receiver；It is 92.9% to colibacillary bacteriostasis rate.
Embodiment
2
(1) preparation of sodium alginate soln: sodium alginate is dissolved in deionized water and stirs 2h at normal temperatures and prepare the sodium alginate soln that mass fraction is 3wt%.
(2) preparation of poly-vinyl alcohol solution: it is the poly-vinyl alcohol solution of 10wt% that a certain amount of polyvinyl alcohol is dissolved in deionized water stirring 4h acquisition mass fraction under conditions of 90 DEG C.
(3) preparation of electrostatic spinning liquid: with the ratio of 5:5, the poly-vinyl alcohol solution of the sodium alginate soln of 3wt% and 10wt% being mixed NaCl stirring 2h that is mixed and that add the mass fraction TX-100 and 0.5wt% as 1.5wt%% and mixs homogeneously, the Chinese medicine antibacterial ingredient berberine stirring 6h the discontinuous degassing that then add the 4wt% of sodium alginate, polyvinyl alcohol quality obtain electrostatic spinning solution.
(4) preparation of nano fibrous membrane: injected by electrostatic spinning solution in the needle tubing of electrostatic spinning apparatus, regulation voltage is 18kV, and the distance of shower nozzle to receptor is 20cm, and flow is 0.8ml/h；Open device for spinning, the sodium alginate nano fiber medical dressing containing 4wt% Chinese medicine antibacterial ingredient berberine can be collected on the receiver；It is 94.3% to colibacillary bacteriostasis rate.
Embodiment
3
(1) preparation of sodium alginate soln: sodium alginate is dissolved in deionized water and stirs 2h at normal temperatures and prepare the sodium alginate soln that mass fraction is 3wt%.
(2) preparation of poly-vinyl alcohol solution: it is the poly-vinyl alcohol solution of 10wt% that a certain amount of polyvinyl alcohol is dissolved in deionized water stirring 4h acquisition mass fraction under conditions of 90 DEG C.
(3) preparation of electrostatic spinning liquid: with the ratio of 5:5, the poly-vinyl alcohol solution of the sodium alginate soln of 3wt% and 10wt% being mixed NaCl stirring 2h that is mixed and that add the mass fraction TX-100 and 0.5wt% as 1.5wt%% and mixs homogeneously, the Chinese medicine antibacterial ingredient berberine stirring 6h the discontinuous degassing that then add the 5wt% of sodium alginate, polyvinyl alcohol quality obtain electrostatic spinning solution.
(4) preparation of nano fibrous membrane: injected by electrostatic spinning solution in the needle tubing of electrostatic spinning apparatus, regulation voltage is 20kV, and the distance of shower nozzle to receptor is 20cm, and flow is 0.8ml/h；Open device for spinning, the sodium alginate nano fiber medical dressing containing 4wt% Chinese medicine antibacterial ingredient berberine can be collected on the receiver；It is 97.1% to colibacillary bacteriostasis rate.
Claims (4)
1. the sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial ingredient berberine, it is characterised in that this material is prepared from by electrostatic spinning means by sodium alginate, polyvinyl alcohol and Chinese medicine antibacterial ingredient berberine.
A kind of sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial ingredient berberine the most according to claim 1, it is characterised in that electrostatic spinning is prepared detailed process and is:
(1) preparation of sodium alginate soln: sodium alginate is dissolved in deionized water and stirs 2h at normal temperatures and prepare the sodium alginate soln that mass fraction is 3wt%；
(2) preparation of poly-vinyl alcohol solution: it is the poly-vinyl alcohol solution of 10wt% that a certain amount of polyvinyl alcohol is dissolved in deionized water stirring 4h acquisition mass fraction under conditions of 90 DEG C；
(3) preparation of electrostatic spinning liquid: with the ratio of 4:6-5:5, the poly-vinyl alcohol solution of the sodium alginate soln of 3wt% and 10wt% being mixed NaCl stirring 2h that is mixed and that add the mass fraction surfactant as 0.5wt%-2wt% and 0.5wt% and mixs homogeneously, the Chinese medicine antibacterial ingredient berberine stirring 6h the discontinuous degassing that then add the 3wt%-6wt% of sodium alginate, polyvinyl alcohol quality obtain electrostatic spinning solution；
(4) preparation of nano fibrous membrane: injected by electrostatic spinning solution in the needle tubing of electrostatic spinning apparatus (as shown in Figure 1), regulation voltage is 12-25kV, and the distance of shower nozzle to receptor is 5-20cm, and flow is 0.1-1.5ml/h；
Open device for spinning, the sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial ingredient berberine can be collected on the receiver.
A kind of sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial ingredient berberine the most according to claim 2, it is characterized in that, surfactant used is TX-100, it it is a kind of nonionic surfactant by U.S. FDA certification, there is nontoxic feature, be widely used in the fields such as cell cultivation.
A kind of sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial ingredient berberine the most according to claim 2, it is characterized in that, Chinese medicine antibacterial ingredient berberine used is a kind of plant essence extracted from Chinese herbal medicine, there is nontoxic feature, and antibacterial will not be made to produce drug resistance, it is a kind of efficiently antibacterial of safety.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510029654.1A CN105854068A (en) | 2015-01-21 | 2015-01-21 | Sodium alginate nanofiber surgical dressing containing traditional Chinese medicine antibiotic component berberine and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510029654.1A CN105854068A (en) | 2015-01-21 | 2015-01-21 | Sodium alginate nanofiber surgical dressing containing traditional Chinese medicine antibiotic component berberine and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105854068A true CN105854068A (en) | 2016-08-17 |
Family
ID=56623024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510029654.1A Pending CN105854068A (en) | 2015-01-21 | 2015-01-21 | Sodium alginate nanofiber surgical dressing containing traditional Chinese medicine antibiotic component berberine and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105854068A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581730A (en) * | 2016-11-24 | 2017-04-26 | 阜阳市汇康医疗器械有限公司 | Antimicrobial deodorant medical cotton swab containing neem oil |
| CN108283727A (en) * | 2018-03-26 | 2018-07-17 | 广东工业大学 | A kind of nanofiber dressing and preparation method thereof |
| CN108686253A (en) * | 2018-06-21 | 2018-10-23 | 东莞市联洲知识产权运营管理有限公司 | A kind of preparation method of high-efficiency antimicrobial medical dressing |
| CN108939136A (en) * | 2018-08-20 | 2018-12-07 | 重庆医科大学附属永川医院 | A kind of dressing and preparation method thereof for nose filling hemostasis |
| CN110124094A (en) * | 2019-04-19 | 2019-08-16 | 青岛大学 | A kind of Chinese herbal medicine based micro-nano fibre antibacterial dressing be prepared in situ and application method |
| CN110241514A (en) * | 2019-04-25 | 2019-09-17 | 扬州纪元纺织有限公司 | A kind of chitosan filament non-woven fabrics and plant-source antibacterial nanofiber composite material and preparation method thereof |
| CN114306710A (en) * | 2021-12-30 | 2022-04-12 | 佛山市中医院 | Medical dressing and preparation method thereof |
| CN115212338A (en) * | 2022-07-12 | 2022-10-21 | 成都大学 | Polycaprolactone-xanthan gum-berberine composite biological membrane and preparation method and application thereof |
| CN117258030A (en) * | 2023-11-20 | 2023-12-22 | 苏州恒星医用材料有限公司 | Calotropis gigantea fiber-based hydrogel dressing, and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011597A (en) * | 2007-01-26 | 2007-08-08 | 东南大学 | Nano fibrous frame material with sodium alginate as matrix and its preparing method |
| CN101062426A (en) * | 2006-04-26 | 2007-10-31 | 北京化工大学 | Antibacterial type blended electro spinning nanometer fiber membrane biological dressing and the preparing method thereof |
| US20100021552A1 (en) * | 2008-05-23 | 2010-01-28 | Convatec Technologies Inc. | Polysaccharide nanofibers having antimicrobial properties |
| CN103990175A (en) * | 2014-06-10 | 2014-08-20 | 吉林大学 | Drug controlled-release double-layer nanofiber wound dressing and preparation method thereof |
-
2015
- 2015-01-21 CN CN201510029654.1A patent/CN105854068A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062426A (en) * | 2006-04-26 | 2007-10-31 | 北京化工大学 | Antibacterial type blended electro spinning nanometer fiber membrane biological dressing and the preparing method thereof |
| CN101011597A (en) * | 2007-01-26 | 2007-08-08 | 东南大学 | Nano fibrous frame material with sodium alginate as matrix and its preparing method |
| US20100021552A1 (en) * | 2008-05-23 | 2010-01-28 | Convatec Technologies Inc. | Polysaccharide nanofibers having antimicrobial properties |
| CN103990175A (en) * | 2014-06-10 | 2014-08-20 | 吉林大学 | Drug controlled-release double-layer nanofiber wound dressing and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张学良等: ""添加不同物质的聚乙烯醇/海藻酸钠静电纺丝研究"", 《合成纤维》 * |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581730A (en) * | 2016-11-24 | 2017-04-26 | 阜阳市汇康医疗器械有限公司 | Antimicrobial deodorant medical cotton swab containing neem oil |
| CN108283727A (en) * | 2018-03-26 | 2018-07-17 | 广东工业大学 | A kind of nanofiber dressing and preparation method thereof |
| CN108686253A (en) * | 2018-06-21 | 2018-10-23 | 东莞市联洲知识产权运营管理有限公司 | A kind of preparation method of high-efficiency antimicrobial medical dressing |
| CN108939136A (en) * | 2018-08-20 | 2018-12-07 | 重庆医科大学附属永川医院 | A kind of dressing and preparation method thereof for nose filling hemostasis |
| CN108939136B (en) * | 2018-08-20 | 2020-12-22 | 重庆医科大学附属永川医院 | Dressing for nasal filling hemostasis and preparation method thereof |
| CN110124094A (en) * | 2019-04-19 | 2019-08-16 | 青岛大学 | A kind of Chinese herbal medicine based micro-nano fibre antibacterial dressing be prepared in situ and application method |
| CN110241514A (en) * | 2019-04-25 | 2019-09-17 | 扬州纪元纺织有限公司 | A kind of chitosan filament non-woven fabrics and plant-source antibacterial nanofiber composite material and preparation method thereof |
| CN114306710A (en) * | 2021-12-30 | 2022-04-12 | 佛山市中医院 | Medical dressing and preparation method thereof |
| CN115212338A (en) * | 2022-07-12 | 2022-10-21 | 成都大学 | Polycaprolactone-xanthan gum-berberine composite biological membrane and preparation method and application thereof |
| CN117258030A (en) * | 2023-11-20 | 2023-12-22 | 苏州恒星医用材料有限公司 | Calotropis gigantea fiber-based hydrogel dressing, and preparation method and application thereof |
| CN117258030B (en) * | 2023-11-20 | 2024-02-13 | 苏州恒星医用材料有限公司 | Calotropis gigantea fiber-based hydrogel dressing, and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105854068A (en) | Sodium alginate nanofiber surgical dressing containing traditional Chinese medicine antibiotic component berberine and preparation method thereof | |
| Dong et al. | Performance of polyvinyl pyrrolidone-isatis root antibacterial wound dressings produced in situ by handheld electrospinner | |
| CN102552966B (en) | Alginate antibacterial dressing and its preparation method | |
| DE69733889T2 (en) | SOLUBLE OXIDES FOR BIOLOGICAL APPLICATIONS | |
| CN102086565B (en) | Polylactic acid antibacterial nanofiber membrane and preparation method thereof | |
| CN103643333B (en) | A kind of for the preparation of the Chinese medicine composition of Woman health viscose, the health care viscose fiber of preparation and preparation method thereof | |
| CN103820880A (en) | Calcium alginate fiber and preparation method thereof | |
| CN104878477B (en) | Method for preparing antibacterial alginate fibers through natural antibacterial agent | |
| CN103225172B (en) | Chondroitin sulfate based nano-fiber nonwoven fabric and preparation method thereof and medical application | |
| CN104207948A (en) | Spinning liquid and method using same to prepare nanofiber film | |
| CN106259509A (en) | A kind of natural plant disinfectant and preparation method thereof | |
| CN104928799A (en) | Preparation method for sustainable antibacterial nano-zinc oxide alginate fibers | |
| CN106906530B (en) | Mosquito-repellent antibacterial cellulose fiber containing wormwood component and preparation method thereof | |
| CN101328624A (en) | Method for preparing superfine antibiotic nanofiber by coaxial electrostatic spinning method | |
| CN103394119A (en) | Method for preparing nanometer bionic slow release biomedical dressing by electrostatic spinning | |
| CN106806049B (en) | A kind of preparation method and medical application of novel graphite alkene material | |
| CN109158058A (en) | Recessed soil-chitosan plural gel and preparation method thereof | |
| CN109252245B (en) | Super-absorbent alginate fiber and preparation method thereof | |
| CN107715183B (en) | Chitosan bone screw material with spiral orientation structure and preparation method thereof | |
| CN108743955A (en) | One kind being used for essential hypertension elastomer subdermal implantation stick | |
| CN103341204B (en) | A kind of antibacterial repair materials and preparation method thereof | |
| EP2647649A1 (en) | Hyaluronic acid gel, method for producing the hyaluronic acid gel and medical product with the hyaluronic acid gel | |
| CN105153458A (en) | Preparation method for low-water-solubility bletilla striata polysaccharide porous membrane | |
| CN105316785B (en) | A kind of preparation method of argy wormwood fiber | |
| CN107535540A (en) | A kind of antiseptic and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160817 |