CN105853947A - Traditional Chinese medicine preparation for treating cirrhosis and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating cirrhosis and preparation method thereof Download PDFInfo
- Publication number
- CN105853947A CN105853947A CN201610488856.7A CN201610488856A CN105853947A CN 105853947 A CN105853947 A CN 105853947A CN 201610488856 A CN201610488856 A CN 201610488856A CN 105853947 A CN105853947 A CN 105853947A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- preparation
- medicine preparation
- liver cirrhosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physiology (AREA)
- Pulmonology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine preparation for treating cirrhosis and a preparation method thereof. The traditional Chinese medicine preparation is prepared from, by weight, 3-5 parts of hirudo, 1-3 parts of Rhizoma curcumae, 10-20 parts of Pu-er raw tea, 5-10 parts of Radix morindae officinalis, 0.2-0.8 part of pig lung extract, 5-20 parts of kelp, 5-15 parts of root of Litsea glutinosa and 10-25 parts of fried hedgehog hide, wherein active ingredients of pig lung extract are one or multiple of phosphatidylcholine, dipalmitoyl phosphatidylcholine, phosphatidyl ethanolamine, phosphatidylserine, phosphatidyl-inositol and sphingomyelin. The preparation method includes: subjecting raw materials to smashing, water extracting or supercritical CO2 extracting and mixing. A principle of regulating kidney, gallbladder and spleen at the same time is adopted, the traditional Chinese medicine preparation has efficacy of clearing heat for detoxification, soothing liver for choleresis, promoting diuresis to treat stranguria, calming liver to regulate qi, activating blood to remove stasis, strengthening heart to lower blood pressure, dispelling wind to stop pain and regulating immunity, is safe, reliable, free of toxic and side effect, short in treatment course, quick in action, low in cost, capable of treating both symptoms and root causes and worthy of wide popularization and application clinically.
Description
Technical field
The present invention relates to technical field of Chinese medicines, a kind of Chinese medicine preparation treating liver cirrhosis and preparation method thereof.
Background technology
Liver cirrhosis is clinical common chronic progressive external hepatopathy, has hepatic necrosis, residual cell tuberosity widely
Property regeneration, connective tissue proliferation and fiber every formation, cause lobules of liver structural deterioration and pseudolobuli to be formed, liver
Gradually deformation, hardening and develop into liver cirrhosis;At present, treatment liver cirrhosis Western medicine essentially consist in early discovery and
Stop course advancement, extending life and holding labour force, it is impossible to fundamentally cure liver cirrhosis, and administration time
Grow, there is side effect, increased the weight of sufferer burden, and most of curative effect is still difficult certainly;The traditional Chinese medical science thinks that liver cirrhosis belongs to
In " long-pending disease ", the category of " tympanites ", liver cirrhosis mostly is with the passing of time protracted inflammation, healthy energy benefit damage and forms spleen and lose strong
The turbid condensation of fortune, qi depression to blood stasis, expectorant, depression of liver-QI, existing Chinese patent medicine existing FUZHENG HUAYU JIAONANG, compound recipe Carapax Trionycis
Soft heparin, peace Lip river chemical fibre ball, Radix Et Rhizoma Rhei et Eupolyphaga Seu Steleophaga Pilulae etc., effect is preferable, and Chinese traditional treatment liver cirrhosis is with a long history,
Can significantly improve hepatocirrhosis symptoms and liver function, safety is high, and curative effect is gratifying;But existing Chinese patent medicine exists
The shortcomings such as prescription is complicated, preparation cost is high, preparation efficiency is low, need badly and improve further and perfect.
Summary of the invention
It is an object of the invention to provide a kind of prescription simply effectively, have no side effect, treatment that cost of manufacture is low
Chinese medicine preparation of liver cirrhosis and preparation method thereof, with the problem solving to propose in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme:
A kind of Chinese medicine preparation treating liver cirrhosis, is made up of according to the raw material of weight portion following: Hirudo 3-5 part,
Rhizoma Curcumae 1-3 part, Pu'er raw tea 10-20 part, Radix Morindae Officinalis 5-10 part, Pulmonis Sus domestica extract 0.2-0.8 part, elder brother
Cloth 5-20 part, residual withered 5-15 part, stir-fry Corium Erinacei Seu Hemiechianus 10-25 part.
As the further scheme of the present invention: the Chinese medicine preparation of described treatment liver cirrhosis, by following according to weight portion
Raw material composition: Hirudo 4 parts, Rhizoma Curcumae 2 parts, Pu'er raw tea 15 parts, Radix Morindae Officinalis 7 parts, Pulmonis Sus domestica extract
0.6 part, Thallus Laminariae (Thallus Eckloniae) 12 parts, residual withered 10 parts, fry Corium Erinacei Seu Hemiechianus 17 parts.
As the present invention further scheme: the effective ingredient of described Pulmonis Sus domestica extract be phosphatidylcholine, two
In Palmic acid phosphatidylcholine, PHOSPHATIDYL ETHANOLAMINE, Phosphatidylserine, phosphinositides and sphingomyelins one
Plant or several.
The preparation method of the Chinese medicine preparation of described treatment liver cirrhosis, comprises the following steps:
1) Rhizoma Curcumae, Radix Morindae Officinalis cleaned and cut into slices, being immersed in rice vinegar solution 3-5 hour, taking out after immersion
Dry and grind, cross 320-550 eye mesh screen, obtain fine powder standby;
2) by Pu'er raw tea, Thallus Laminariae (Thallus Eckloniae), residual withered clean up and take impurity, being placed in extraction pot, with 1:10
Solid-liquid ratio add 5-10 times of distilled water, heating and refluxing extraction 3-5 hour under the conditions of 60 DEG C, boil 1-2
Hour, obtaining extracting solution, extracting solution is condensed into the extractum that relative density is 1.18-1.24 after secondary filter, cold
But standby to room temperature;
3) by microwave drying after Hirudo, stir-fry Corium Erinacei Seu Hemiechianus decontamination, cross 180-260 eye mesh screen after pulverizing, load
In extraction kettle, use supercritical CO2Abstraction technique extracts, and controls extracting pressure position 35-45MPa, extraction
Temperature is 28-32 DEG C, and separation temperature is 35-40 DEG C, extraction time 1-2 hour, obtains extract, will extraction
Thing is concentrated into the extractum that relative density is 1.18-1.24, is cooled to room temperature standby;
4) extractum obtained in the fine powder obtained in step 1, step 2 and step 3 is added the pig of formula ratio
It is sufficiently mixed after lung extract, obtains finished product.
As the present invention further scheme: in described step 1, in rice vinegar solution, acetic acid content is 20-30%.
As the present invention further scheme: the extractum obtained in described step 2 and step 3 enters after the cooling period
Row ultraviolet disinfection processes.
As the present invention further scheme: the finished product obtained in described step 4 is through conventional Chinese medicine preparation
Preparation method is prepared as treating the tablet of liver cirrhosis, granule, pill, capsule, syrup.
In the present invention, the pharmacological action of each component is as follows:
1. Hirudo: salty, bitter, flat;Return Liver Channel;Removing blood stasis stimulates the menstrual flow, removing blood stasis eliminating mass;For treating apoplexy, high blood
Pressure, the clear stasis of blood, amenorrhea, traumatic injury, have specially good effect at preventing and treating cardiovascular and cerebrovascular disease and anticancer aspect;Hirudin
There is anticoagulant antithrombotic effect, hirudin include aspartic acid, glutamic acid, half bladder acid, serine, glycine,
Threonine, alanine, valine, leucine, isoleucine, proline, phenylalanine, cruel propylhomoserin, group
Propylhomoserin and lysine;Additionally possibly together with heparin and antithromboxin in Hirudo, have anticoagulation, improve microcirculatory
Effect, has fibrinolytic in vivo, rabbit euglobulin lysis time can be made significantly to shorten, can activate fibrinolytic system
System, thrombus, experimental vein thrombosis there is is obvious inhibiting effect, to the experimental vein caused by thrombin
Thrombosis has dissolution;Patients with ischemic cerebral vascular disease occur because of hemorheology sexual abnormality is dense, glutinous, poly-
State has improvement result.、
2. Rhizoma Curcumae: acrid, bitter, warm;Return liver, spleen channel;Can removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving;The volatile oil of Rhizoma Curcumae
In containing Rhizoma Curcumae furan ketenes, Borneolum Syntheticum, limonene and have the curcumin chemical compounds of antioxidant activity;Tool
Have antitumor, antibacterial, leukocyte increasing, removing cardiovascular and cerebrovascular vessel thrombosis, promote gastrointestinal smooth muscle power, protect the liver,
Treatment acute renal failure, suppression platelet aggregation, antithrombus formation, antiinflammatory action.
3. Pu'er raw tea: Pu'er have cleaning intestinal, blood fat reducing, refresh oneself, blood pressure lowering and effect of weight reducing, the fall in Pu'er
Fat effect comes from the plurality of active ingredients such as tea polyphenols, chlorophyll, vitamin C, shape after the processed fermentation in Pu'er
The profitable strain become also can reduce triglyceride and the absorption of sugar, improves ferment and decomposes waist and belly fat;Can
Make cholesterol and glyceride reduce, cause the vasodilation of people, blood pressure drops, decreased heart rate and cerebral blood flow
The physiological effecies such as minimizing, have good therapeutical effect to hypertension and cerebral arteriosclerosis patient.
4. Radix Morindae Officinalis: Labiatae Rabdosia, bitter in the mouth, sweet;Cold nature;Heat-clearing and toxic substances removing, promoting blood circulation and stopping pain;Main
Control laryngopharynx swelling and pain, headache due to common cold, tracheitis, chronic hepatitis, rheumatic arthritis, snake bite and insect sting;Have good
Heat clearing away poison, promoting blood circulation and stopping pain, antibacterial, antitumor action;Rabdosia rubescens contain rubescensine A, rubescensine B and
Rosmarinic acid, rubescensine A, rubescensine B have antitumaous effect, have primary hepatocarcinoma and substantially alleviate disease
Shape effect, has stable and reduces tumor body and extend the effect of patients ' lives;Rabdosia rubescens and chemotherapy, other anticarcinogens
Thing partner treatment cancer has obvious potentiation;Good antimicrobial effect, decoct and the alcohol agent of Rabdosia rubescens can be effective
Suppression A type and beta hemolytic streptococcus, staphylococcus aureus etc., improve human body resistance, drop rapidly
The low leukocyte caused because of inflammation increases.
5. Pulmonis Sus domestica extract: Pulmonis Sus domestica sweet in the mouth, property is put down, and returns lung meridian, tonifying the lung and stopping cough, stops blooding, for cough due to deficiency of the lung,
Spitting of blood;Cholesterol in blood and fatty acid can be superfine granule by its effective ingredient phosphatidylcholine, from
In blood vessel discharge, increase high density lipoprotein, make blood vessel recover elasticity, blood flow is unimpeded, have blood circulation promoting and blood stasis dispelling,
The effect of wind-expelling pain-stopping.
6. Thallus Laminariae (Thallus Eckloniae): salty in the mouth, cold in nature is nontoxic;Return liver, stomach, kidney channel;Hard masses softening and resolving, relaxing the bowels with lubricant drugs expectorant, detumescence
Diuretic;Rich in crude protein, crude fibre, calcium, ferrum, carotene, thiamine, riboflavin and nicotinic acid;Elder brother
The iodine extracted in cloth and the hardening of alginic acid energy prevention of arterial, reduction cholesterol and the accumulation of fat;Alginic acid sodium salt energy
Effective pre-preventing leukemia and Itai-itai diseases, also have anastalsis to arterial hemorrhage;Sodium alginate has hypotensive effect,
Thallus Laminariae (Thallus Eckloniae) starch has effect for reducing fat;Thallus Laminariae (Thallus Eckloniae) mannitol to treatment acute renal decline, cerebral edema, encephalitis B,
Acute glaucoma is the most effective in cure;The hemopoietic tissue damage that the also band polysaccharide of Thallus Laminariae (Thallus Eckloniae) is caused for preventive radiotherapy, thorn
Swash Radiation in jury and strengthen the immunologic function of cancer patient, merging radiotherapy and there is positive role.
The most residual withered: bitter in the mouth, cold in nature;Volatile oil in fruit has specific action to central nervous system;Ye Han
There are naringin, astragalin, Quercetin-3-rhamnoside, nimbecetin-7-glycoside, pelargonidin-3-
Glycoside, tannin;Bark contains water miscible araboxylan, wherein xylose and arabinose mole
Ratio is 1.0:3.4;Cure mainly dysentery, enteritis, rheumatic ostalgia, parotitis, mastitis, furuncle;
8. frying Corium Erinacei Seu Hemiechianus: bitter in the mouth, sweet, property is put down;Return stomach, large intestine, kidney channel;Blood-activating analgetic, astringing to arrest bleeding, solid
Essence;For gastralgia, metrorrhagia, have blood in stool, discharging fresh blood stool, proctoptosis, hemorrhoid, seminal emission, the enuresis;Thorn
Hedgehog skin has anastalsis and promotes smooth muscle creeping effect;Rich in K, Na, Ca, Fe, Zn in Corium Erinacei Seu Hemiechianus, Zn
It is the main component of carbonic anhydrase, DNA and RNA polymerase, is fused and joins object, albumen at biomacromolecule
In matter, nucleic acid and biomembrane, form the stable macromolecule complex containing metal, metalloprotein, metalloproteinase nucleic acid
Coordination compound, plays a part to be catalyzed Active Regulation and rock-steady structure, have heat clearing away, removing toxic substances, removing heat from blood, antiinflammatory,
Effect of granulation promoting, particularly with fibroblastic propagation and the formation of epithelium and regeneration, has facilitation.
Compared with prior art, the invention has the beneficial effects as follows: compared with Western medicine preparation, the Chinese medicine system of the present invention
Agent has the feature of " Mutiple Targets, manifold effect ", and medical material compatibility selected by the present invention is suitable, meet Chinese medicine and pharmacy and
Modern medicine theory, with dialectical treatmert for this, is to follow wet, hot, strongly fragrant, the stasis of blood, the development of poison according to hepatopathy
Process, through clinical experience, probes boldly after conscientious research, screening constitute " blood circulation promoting and blood stasis dispelling, soft contracting liver spleen,
Softening the hard mass diuretic " effective prescription of primary treatment liver cirrhosis;The Chinese medicine preparation of the present invention has heat-clearing and toxic substances removing, dredges
Effect that liver function of gallbladder promoting, inducing diuresis for treating stranguria syndrome, suppressing the hyperactive liver are regulated the flow of vital energy, meanwhile, the traditional Chinese medical science stresses yin-yang and five elements and controlling of counteracting each other
Treatment method, therefore during treatment liver cirrhosis, the principle using kidney, gallbladder, spleen simultaneously to nurse one's health, reach specimen
The double purpose controlled;The present invention has blood circulation promoting and blood stasis dispelling, heart tonifying blood pressure lowering, wind-expelling pain-stopping, the effect of regulation immunity, safety
Reliably, without any side effects, short treating period, instant effect, with low cost, and the mesh for the treatment of both the principal and secondary aspects of a disease can be reached
, wide popularization and application on clinic.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the technical scheme of this patent is described in more detail.
Embodiment 1
A kind of Chinese medicine preparation treating liver cirrhosis, is made up of according to the raw material of weight portion following: Hirudo 3 parts, cowherb
Art 1 part, Pu'er raw tea 10 parts, Radix Morindae Officinalis 5 parts, Pulmonis Sus domestica extract 0.2 part, Thallus Laminariae (Thallus Eckloniae) 5 parts, residual withered
5 parts, stir-fry Corium Erinacei Seu Hemiechianus 10 parts.
Embodiment 2
A kind of Chinese medicine preparation treating liver cirrhosis, is made up of according to the raw material of weight portion following: Hirudo 5 parts, cowherb
Art 3 parts, Pu'er raw tea 20 parts, Radix Morindae Officinalis 10 parts, Pulmonis Sus domestica extract 0.8 part, Thallus Laminariae (Thallus Eckloniae) 20 parts, residual withered
15 parts, stir-fry Corium Erinacei Seu Hemiechianus 25 parts.
Embodiment 3
A kind of Chinese medicine preparation treating liver cirrhosis, is made up of according to the raw material of weight portion following: Hirudo 4 parts, cowherb
Art 2 parts, Pu'er raw tea 13 parts, Radix Morindae Officinalis 6 parts, Pulmonis Sus domestica extract 0.3 part, Thallus Laminariae (Thallus Eckloniae) 10 parts, residual withered
9 parts, stir-fry Corium Erinacei Seu Hemiechianus 15 parts.
Embodiment 4
A kind of Chinese medicine preparation treating liver cirrhosis, is made up of according to the raw material of weight portion following: Hirudo 5 parts, cowherb
Art 2 parts, Pu'er raw tea 17 parts, Radix Morindae Officinalis 8 parts, Pulmonis Sus domestica extract 0.7 part, Thallus Laminariae (Thallus Eckloniae) 15 parts, residual withered
12 parts, stir-fry Corium Erinacei Seu Hemiechianus 22 parts.
Embodiment 5
A kind of Chinese medicine preparation treating liver cirrhosis, is made up of according to the raw material of weight portion following: Hirudo 4 parts, cowherb
Art 2 parts, Pu'er raw tea 15 parts, Radix Morindae Officinalis 7 parts, Pulmonis Sus domestica extract 0.6 part, Thallus Laminariae (Thallus Eckloniae) 12 parts, residual withered
10 parts, stir-fry Corium Erinacei Seu Hemiechianus 17 parts.
In the Chinese medicine preparation of the treatment liver cirrhosis described in embodiment 1-5, the effective ingredient of Pulmonis Sus domestica extract is phospholipid
Phatidylcholine, DPPC, PHOSPHATIDYL ETHANOLAMINE, Phosphatidylserine, phosphinositides and sheath
One or more in phospholipid.
The preparation method of the Chinese medicine preparation of the treatment liver cirrhosis described in embodiment 1-5, comprises the following steps:
1) Rhizoma Curcumae, Radix Morindae Officinalis cleaned and cut into slices, being immersed in rice vinegar solution 3-5 hour, in rice vinegar solution
Acetic acid content is 20-30%, takes out and dries and grind, cross 320-550 eye mesh screen, obtain fine powder standby after immersion
With;
2) by Pu'er raw tea, Thallus Laminariae (Thallus Eckloniae), residual withered clean up and take impurity, being placed in extraction pot, with 1:10
Solid-liquid ratio add 5-10 times of distilled water, heating and refluxing extraction 3-5 hour under the conditions of 60 DEG C, boil 1-2
Hour, obtaining extracting solution, extracting solution is condensed into the extractum that relative density is 1.18-1.24 after secondary filter, cold
But to room temperature, ultraviolet disinfection is standby after processing;
3) by microwave drying after Hirudo, stir-fry Corium Erinacei Seu Hemiechianus decontamination, cross 180-260 eye mesh screen after pulverizing, load
In extraction kettle, use supercritical CO2Abstraction technique extracts, and controls extracting pressure position 35-45MPa, extraction
Temperature is 28-32 DEG C, and separation temperature is 35-40 DEG C, extraction time 1-2 hour, obtains extract, will extraction
Thing is concentrated into the extractum that relative density is 1.18-1.24, is cooled to room temperature, and ultraviolet disinfection is standby after processing;
4) extractum obtained in the fine powder obtained in step 1, step 2 and step 3 is added the pig of formula ratio
It is sufficiently mixed after lung extract, obtains finished product.
The finished product obtained in described step 4 is prepared as treating liver cirrhosis through the preparation method of conventional Chinese medicine preparation
Tablet, granule, pill, capsule, syrup.
The effect that the present invention treats further liver cirrhosis below in conjunction with experiment is illustrated:
1. using the embodiment of the present invention 5 preparation for treating the Chinese medicine preparation of liver cirrhosis as experimental group medicine, with
Commercially available Anluohuaxianwan pill medicine as a control group, chooses 32 Kunming rats, is divided into 4 groups, often group eight,
Male and female half and half, four groups arrange and are administered respectively as follows: the 1st group be normal group, the 2nd group be model group, the 3rd
Group for Anluohuaxianwan pill medication group, the 4th group be the embodiment of the present invention 5 medication group;By 2-4 group rat first
Subcutaneous injection 100% carbon trichloride 5ml/kg, thereafter 50% carbon tetrachloride-olive oil solution 2ml/kg, weekly 2
Secondary, totally 9 weeks;1st group of rat injection, with the olive oil of dosage, respectively organized dosage 5g/kg after these 6 weeks,
After treating 3 weeks, after each group residue rat is with 2% barbital sodium intraperitoneal injection of anesthesia, postcava is taken a blood sample, and
Take hepatic tissue specimen;Observe hepatic tissue strong proline (Hyp) content (JamallShi method);Serum ALT,
AST, GGT activity, serum alb, Tbil content, result is as shown in table 1-4:
Project | Hyp (micro-gram gram) | P value |
1st group | 138.18±35.93 | ≤0.05 |
2nd group | 369.14±42.07 | ≤0.05 |
3rd group | 265.59±83.25 | ≤0.05 |
4th group | 232.35±89.56 | ≤0.05 |
Table 1 present invention impact on the rat Hyp (micro-gram gram) of hepatic injury
Project | ALT(U/ml) | AST(U/ml) | P value |
1st group | 31.73±8.52 | 46.65±9.08 | ≤0.05 |
2nd group | 152.85±23.64 | 135.57±28.85 | ≤0.05 |
3rd group | 97.94±32.14 | 92.87±29.63 | ≤0.05 |
4th group | 80.53±25.83 | 85.88±18.96 | ≤0.05 |
Table 2 present invention impact on rat ALT, AST of hepatic injury
Project | GGT(U/ml) | P value |
1st group | 11.02±3.59 | ≤0.05 |
2nd group | 55.48±11.95 | ≤0.05 |
3rd group | 37.12±5.89 | ≤0.05 |
4th group | 27.18±11.59 | ≤0.05 |
Table 3 present invention impact on the rat GGT of hepatic injury
Project | ALT(U/ml) | AST(U/ml) | P value |
1st group | 0.59±0.31 | 37.89±1.94 | ≤0.05 |
2nd group | 1.17±0.58 | 24.95±3.68 | ≤0.05 |
3rd group | 1.21±0.23 | 35.27±2.97 | ≤0.05 |
4th group | 0.83±0.19 | 29.03±3.25 | ≤0.05 |
Table 4 present invention impact on rat Tbil, Alb of hepatic injury
As shown in table 1-4, above-mentioned experiment shows: model group liver Hyp content, Serum ALT, AST, GGT
Activity, and Tbil work content significantly raises, Alb content is remarkably decreased;The liver Hyp of medicine group of the present invention
Content, Serum ALT, AST, GGT activity, and Tbil work content be substantially less than model group, and Alb content
It is significantly higher than model group, and compared with 3 groups, there is significant difference;Being shown experimentally that, the present invention is to tetrachloro
Change the Liver Damage in Rats caused by carbon, hepatic fibrosis has significant therapeutic effect.
The animal toxicity test report of Chinese medicine preparation of the present invention:
Taking rabbit 30, male and female dual-purpose, body weight 1.5-2kg, divide two groups, often group 15, one of which is
Overdose test group, another group is normal amount test group;Taking the former medicine of Chinese medicine preparation of the present invention, super quantity tries
Testing group and be administered 20ml/kg, normal amount test group is administered 10ml/kg, and administering mode is that administration by gavage is administered, every day two
Secondary, serve on seven days, observe every day and be administered reaction, result shows that two groups of rabbit are movable, diet are normal, medicine without
Bad toxic and side effects.
The clinical observation on the therapeutic effect of Chinese medicine preparation of the present invention:
1. the object of observation: accept liver cirrhosis out-patient totally 200 example for medical treatment.
2. diagnostic criteria: classical symptom is the hepatosplenomegaly that hematopathy, metabolic disease cause, and hepatitis can be had to face
Bed performance, also can hide onset;Can there be the most weak, abdominal distention, liver spleen jaundice the most great, slight, Aranea
Nevus;The symptoms such as loss of appetite, abdominal distention, gastrointestinal dysfunction, hydrothorax, double lower limbs edema.
3. Therapeutic Method: select the medicine treating liver cirrhosis prepared by the Chinese medicine preparation of the embodiment of the present invention 5, give
Patient takes, and each takes potion, and every day is the most each once, within 7 days, is a course for the treatment of, takes 3 treatments continuously
Journey.
4. efficacy assessment standard:
Curing: hepatocirrhosis symptoms disappears, body constitution recovers normal, recovery from illness;
Effective: Liver And Spleen of Patients enlargement, abdominal distention, gastrointestinal dysfunction, slight jaundice phenomenon alleviate, liver cirrhosis disease
Shape is clearly better, and body constitution is progressively recovered;
Invalid: not reach effective standard person.
5. therapeutic outcome is as shown in the table:
Table 5 clinical test results
The Chinese medicine preparation of the present invention is used for the therapeutic outcome of 200 liver cirrhosis patients as shown above, three treatments
In the therapeutic process of journey, curing 167 examples, effective 29 examples, invalid 4 examples, the cure rate of the present invention is 83.5%,
Obvious effective rate is 14.5%, and inefficiency is 2%, aggregate efficiency Ei 98%.
6. model case citing:
Song, female, 50 years old, the year before last, patient started to occur that red urine was deficient, constipation, indigestion and loss of appetite, abdomen
Swollen, the most weak, jaundice, the symptom such as be off one's feed, because Hepatocirrhosis is at certain hospitalize two wheat harvesting period,
Because curative effect does not shows, after leaving hospital, use the Chinese medicine preparation of the present invention instead, each potion, every bu twice sooner or later, two
After the course for the treatment of, above-mentioned symptom has been alleviated, and jaundice disappears substantially, and appetite is obviously improved, and conscious spirit is strong, continues
Continuing after taking two courses for the treatment of, all diseases disappear, and health substantially recovers normal, follows up a case by regular visits to have no recurrence.
Cai, man, 55 years old, sense intermittent distending pain when starting to occur right rib before 5 years, inappetence, oliguria,
The symptoms such as abdominal distention, to examination in hospital, liver function test is abnormal, is diagnosed as cirrhotic ascites in early days, and western modern medicine is controlled
Treat three months subjective symptomss, sign and liver function test all without improving, use Chinese medicine preparation of the present invention instead, take one
After the individual course for the treatment of, voided volume time showed increased, abdominal distention, costalgia alleviate, and abdominal circumference reduces, after take again two treatments
Journey, diet increases, two just, abdominal circumference recover normal, liver and spleen retraction or the deliquescing that substantially bounces back, jaundice, ascites disappear
Moving back, liver function test is normal, can be engaged in light physical labor, follow up a case by regular visits to have no recurrence.
River, man, 42 years old, conscious before 3 years there is general weakness without clear and definite inducement, the most double lower limb
Become apparent from, can alleviate after rest, the symptoms such as jaundice, weak, Nausea and vomiting and inappetence occur,
Sometimes turn sour with back and extremities joint is ached, be diagnosed as hepatitis C liver cirrhosis to examination in hospital, use Western medicine
Treatment, effect does not shows, and then uses the Chinese medicine preparation of the present invention to treat, each potion, every bu twice clothes sooner or later
With, after taking 2 courses for the treatment of, Nausea and vomiting transference cure, continues to take two courses for the treatment of, back, extremity pain
Disappear, patient identifies oneself to brace up, and appetite increases, and health recovers normal substantially, stable disease half a year with
On, follow up a case by regular visits to have no recurrence.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned enforcement
Mode, in the ken that one skilled in the relevant art is possessed, it is also possible to without departing from this patent ancestor
On the premise of purport, various changes can be made.
Claims (7)
1. the Chinese medicine preparation treating liver cirrhosis, it is characterised in that be made up of according to the raw material of weight portion following:
Hirudo 3-5 part, Rhizoma Curcumae 1-3 part, Pu'er raw tea 10-20 part, Radix Morindae Officinalis 5-10 part, Pulmonis Sus domestica extract 0.2-0.8
Part, Thallus Laminariae (Thallus Eckloniae) 5-20 part, residual withered 5-15 part, stir-fry Corium Erinacei Seu Hemiechianus 10-25 part.
The Chinese medicine preparation for the treatment of liver cirrhosis the most according to claim 1, it is characterised in that by following according to
The raw material composition of weight portion: Hirudo 4 parts, Rhizoma Curcumae 2 parts, Pu'er raw tea 15 parts, Radix Morindae Officinalis 7 parts, Pulmonis Sus domestica
Extract 0.6 part, Thallus Laminariae (Thallus Eckloniae) 12 parts, residual withered 10 parts, stir-fry Corium Erinacei Seu Hemiechianus 17 parts.
3. according to the Chinese medicine preparation of the arbitrary described treatment liver cirrhosis of claim 1-2, it is characterised in that described
The effective ingredient of Pulmonis Sus domestica extract is phosphatidylcholine, DPPC, PHOSPHATIDYL ETHANOLAMINE, phosphorus
One or more in acyl serine, phosphinositides and sphingomyelins.
4. a preparation method for the Chinese medicine preparation of the treatment liver cirrhosis as described in claim 1-2 is arbitrary, it is special
Levy and be, comprise the following steps:
1) Rhizoma Curcumae, Radix Morindae Officinalis cleaned and cut into slices, being immersed in rice vinegar solution 3-5 hour, taking out after immersion
Dry and grind, cross 320-550 eye mesh screen, obtain fine powder standby;
2) by Pu'er raw tea, Thallus Laminariae (Thallus Eckloniae), residual withered clean up and take impurity, being placed in extraction pot, with 1:10
Solid-liquid ratio add 5-10 times of distilled water, heating and refluxing extraction 3-5 hour under the conditions of 60 DEG C, boil 1-2
Hour, obtaining extracting solution, extracting solution is condensed into the extractum that relative density is 1.18-1.24 after secondary filter, cold
But standby to room temperature;
3) by microwave drying after Hirudo, stir-fry Corium Erinacei Seu Hemiechianus decontamination, cross 180-260 eye mesh screen after pulverizing, load
In extraction kettle, use supercritical CO2Abstraction technique extracts, and controls extracting pressure position 35-45MPa, extraction
Temperature is 28-32 DEG C, and separation temperature is 35-40 DEG C, extraction time 1-2 hour, obtains extract, will extraction
Thing is concentrated into the extractum that relative density is 1.18-1.24, is cooled to room temperature standby;
4) extractum obtained in the fine powder obtained in step 1, step 2 and step 3 is added the pig of formula ratio
It is sufficiently mixed after lung extract, obtains finished product.
The preparation method of the Chinese medicine preparation for the treatment of liver cirrhosis the most according to claim 4, it is characterised in that
In described step 1, in rice vinegar solution, acetic acid content is 20-30%.
The preparation method of the Chinese medicine preparation for the treatment of liver cirrhosis the most according to claim 4, it is characterised in that
The extractum obtained in described step 2 and step 3 carries out ultraviolet disinfection process after the cooling period.
The preparation method of the Chinese medicine preparation for the treatment of liver cirrhosis the most according to claim 4, it is characterised in that
The finished product obtained in described step 4 is prepared as treating the sheet of liver cirrhosis through the preparation method of conventional Chinese medicine preparation
Agent, granule, pill, capsule, syrup.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610488856.7A CN105853947A (en) | 2016-06-29 | 2016-06-29 | Traditional Chinese medicine preparation for treating cirrhosis and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610488856.7A CN105853947A (en) | 2016-06-29 | 2016-06-29 | Traditional Chinese medicine preparation for treating cirrhosis and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105853947A true CN105853947A (en) | 2016-08-17 |
Family
ID=56656008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610488856.7A Pending CN105853947A (en) | 2016-06-29 | 2016-06-29 | Traditional Chinese medicine preparation for treating cirrhosis and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105853947A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106173012A (en) * | 2016-08-31 | 2016-12-07 | 王晓芬 | A kind of health-care tea with thrombosis ablation |
CN110028576A (en) * | 2019-04-12 | 2019-07-19 | 海安华达石油仪器有限公司 | A method of leech is extracted with supercritical carbon dioxide |
JP2019196330A (en) * | 2018-05-10 | 2019-11-14 | 株式会社萌芽プランツ | Carbohydrate absorption inhibitor |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101342338A (en) * | 2008-08-29 | 2009-01-14 | 邵立红 | Medicament for treating hepatopathy |
CN101618172A (en) * | 2009-02-19 | 2010-01-06 | 王增楼 | Traditional Chinese medicine for treating hepatitis B, cirrhosis, liver cancer and liver ascites |
CN105561149A (en) * | 2014-10-14 | 2016-05-11 | 许俊 | Traditional Chinese medicine formula for treatment of cirrhotic splenomegaly |
-
2016
- 2016-06-29 CN CN201610488856.7A patent/CN105853947A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101342338A (en) * | 2008-08-29 | 2009-01-14 | 邵立红 | Medicament for treating hepatopathy |
CN101618172A (en) * | 2009-02-19 | 2010-01-06 | 王增楼 | Traditional Chinese medicine for treating hepatitis B, cirrhosis, liver cancer and liver ascites |
CN105561149A (en) * | 2014-10-14 | 2016-05-11 | 许俊 | Traditional Chinese medicine formula for treatment of cirrhotic splenomegaly |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106173012A (en) * | 2016-08-31 | 2016-12-07 | 王晓芬 | A kind of health-care tea with thrombosis ablation |
JP2019196330A (en) * | 2018-05-10 | 2019-11-14 | 株式会社萌芽プランツ | Carbohydrate absorption inhibitor |
JP7142857B2 (en) | 2018-05-10 | 2022-09-28 | 株式会社萌芽プランツ | Carbohydrate absorption inhibitor |
CN110028576A (en) * | 2019-04-12 | 2019-07-19 | 海安华达石油仪器有限公司 | A method of leech is extracted with supercritical carbon dioxide |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102048894B (en) | Traditional Chinese medicine composition for treating burn and preparation method thereof | |
CN102772781A (en) | Traditional Chinese medicine preparation for treating chronic colitis and preparation method thereof | |
CN105853947A (en) | Traditional Chinese medicine preparation for treating cirrhosis and preparation method thereof | |
CN105250821B (en) | A kind of compound Chinese medicinal preparation and preparation method thereof for treating ulcerative colitis | |
CN102847124B (en) | Medicine for treating infantile diarrhea and preparation method thereof | |
CN107913370A (en) | A kind of medicine and preparation method of therapy of combing traditional Chinese and Western medicine alcoholic liver disease | |
CN104258278A (en) | Gushangling (for bone injury) spray | |
CN103721224B (en) | A kind of medicine for the treatment of chronic non-specific ulcerative colitis and preparation method thereof | |
CN104324261A (en) | Pharmaceutical composition for treating high blood sugar and preparation method of pharmaceutical composition | |
CN107349223A (en) | A kind of stem cell drink for improving cell viability and preparation method thereof | |
CN104435669B (en) | The Chinese medicine composition of the concurrent multiple organ dysfunction syndrome for the treatment of septic shock | |
CN106421535A (en) | Medicine for treating gouty arthritis and preparation method thereof | |
CN105214037A (en) | The solid dispersal capsule for the treatment of peptic ulcer | |
CN104623057A (en) | Pharmaceutical composition for treating diabetic feet and application pf pharmaceutical composition | |
CN103285360B (en) | Traditional Chinese medicinal preparation for treating thromboangiitis obliterans, and preparation method thereof | |
CN116850257A (en) | Traditional Chinese medicine for treating varicose veins | |
CN105311518A (en) | Medicine for treating asthma and preparation method thereof | |
CN104667107A (en) | Medicine for treating summerheat injuring lung and stomach summer fever in children and preparation method of medicine | |
CN104225009A (en) | Traditional Chinese medicine composition for treating diarrhea | |
CN116270949A (en) | Traditional Chinese medicine composition for reducing hyperuricemia and preparation method thereof | |
CN104056120A (en) | Drug for treatment of deep phlebitis and preparation method thereof | |
CN110464774A (en) | A kind of compound hydrochloric acid Propranolol oral solution for treating infantile hemangioma | |
CN113332365A (en) | Compound lithospermum ointment and preparation method thereof | |
CN109646563A (en) | A kind of Chinese medicinal capsule for treating cerebral thrombosis | |
CN113181247A (en) | Preparation process of radix paeoniae alba for treating hemorrhoids |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination |