CN105853890A - Medicine composition for stopping vomit and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine composition for stopping vomit and a preparation method thereof. The medicine composition is prepared from potentill anserine, the root of longflower stringbush, coptis chinensis, coix seeds, radix codonopsis, Aeschynanthus acuminatus Wall.[A. chinensis Gardn. et Champ.], Calystegia hederacea, Chinese dates, bulbophyllum, pawpaw, Herb of Grenateleaf Hetreopappus, Berchemia sinica, all-grass of Korean Lovegrass, round cardamom, curcuma zedoary, whitefruit stonecrop herb, root of Sandhill Tylophora, henry sarmentose fig receptacle, Cynanchum glaucescens, Spreading Hedyotis, Herb of Clavateleaf Oberonia, fructus alpiniae oxyphyllae, Root of Apricotleaf Ladybell, Buddleja officinalis and cassia seeds. The medicine composition has the advantages of having the effects of managing the spleen and stomach, invigorating spleen and supplementing qi, and tonifying stomach and nourishing the liver, also having the effects of diminishing inflammation, promoting digestion and stopping pain, being capable of protecting intestines and stomach and effectively adjusting the body immunity function, short in treatment course, good in treatment effect, free of medicine resistance and medicine residue and low in cost, and the like.

Description

A kind of pharmaceutical composition for antiemetic and preparation method thereof

Technical field

The present invention relates to field of veterinary, particularly to the antiemetic composition for the animal such as dog, cat.

Background technology

About antiemetic, what current people commonly used has metoclopramide, Ai Maoer, atropine, Cobastab₆Deng, metoclopramide is the medicine of the bidirectional modulation gastrointestinal peristalsis acting on Enteric nervous plexus, and Ai Maoer is general antiemetic, and atropine is anticholinergic agent and antiemetic is weak, Cobastab₆Only vomiting during gestation there is antiemetic effect.The antiemetic effect of these antiemetics above-mentioned is the most highly desirable, and the animal such as dog, cat is easy vomiting animals, uses these medicine many control symptom effects the most notable.

Summary of the invention

The technical problem to be solved is to be to provide a kind of pharmaceutical composition for antiemetic and preparation method thereof, can overcome the various defects of Chinese medicine of the prior art and Western medicine.

In order to realize foregoing invention purpose, the invention provides a kind of pharmaceutical composition for antiemetic, described pharmaceutical composition includes following raw medicinal material: fern fiber crops, longflower stringbush root, the coptis, coix seed, Radix Codonopsis, ivy glorybind, date, pawpaw, grenateleaf heteropappus herb, hook catechu, Herba Eragrostidis ferrugineae, cardamom, rock pine, unpleasant swallowwort herb, Cynanchum glaucescens, chun spicebush root, rock green onion, fructus alpiniae oxyphyllae, butterflybush flower and cassia seed.

Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: fern fiber crops 10-20 weight portion, longflower stringbush root 15-35 weight portion, coptis 14-34 weight portion, coix seed 14-42 weight portion, Radix Codonopsis 11-21 weight portion, ivy glorybind 13-33 weight portion, date 15-35 weight portion, pawpaw 12-24 weight portion, grenateleaf heteropappus herb 16-34 weight portion, hook catechu 12-22 weight portion, Herba Eragrostidis ferrugineae 10-35 weight portion, cardamom 13-33 weight portion, rock pine 12-24 weight portion, unpleasant swallowwort herb 12-36 weight portion, Cynanchum glaucescens 14-28 weight portion, chun spicebush root 9-18 weight portion, rock green onion 10-23 weight portion, fructus alpiniae oxyphyllae 8-16 weight portion, butterflybush flower 13-35 weight portion and cassia seed 12-22 weight portion.

Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: fern fiber crops 14 weight portions, longflower stringbush root 32 weight portion, the coptis 26 weight portion, coix seed 40 weight portion, Radix Codonopsis 20 weight portion, ivy glorybind 32 weight portion, date 24 weight portion, pawpaw 14 weight portion, grenateleaf heteropappus herb 33 weight portion, hook catechu 20 weight portion, Herba Eragrostidis ferrugineae 35 weight portion, cardamom 32 weight portion, rock pine 22 weight portions, unpleasant swallowwort herb 36 weight portion, Cynanchum glaucescens 24 weight portion, chun spicebush root 16 weight portion, rock green onion 20 weight portion, fructus alpiniae oxyphyllae 15 weight portion, butterflybush flower 33 weight portion and cassia seed 18 weight portion.

In described pharmaceutical composition, each raw medicinal material also includes: Shi Rong, curcuma zedoary, Bulbophyllum calodictyon schlecht, henry sarmentose fig receptacle and shepherd's purse.

nullIn described pharmaceutical composition, the parts by weight of each raw medicinal material are: fern fiber crops 10-20 weight portion、Longflower stringbush root 15-35 weight portion、Coptis 14-34 weight portion、Coix seed 14-42 weight portion、Radix Codonopsis 11-21 weight portion、Ivy glorybind 13-33 weight portion、Date 15-35 weight portion、Pawpaw 12-24 weight portion、Grenateleaf heteropappus herb 16-34 weight portion、Hook catechu 12-22 weight portion、Herba Eragrostidis ferrugineae 10-35 weight portion、Cardamom 13-33 weight portion、Rock pine 12-24 weight portion、Unpleasant swallowwort herb 12-36 weight portion、Cynanchum glaucescens 14-28 weight portion、Chun spicebush root 9-18 weight portion、Rock green onion 10-23 weight portion、Fructus alpiniae oxyphyllae 8-16 weight portion、Butterflybush flower 13-35 weight portion、Cassia seed 12-22 weight portion、Stone banyan 7-14 weight portion、Curcuma zedoary 10-22 weight portion、Bulbophyllum calodictyon schlecht 12-34 weight portion、Henry sarmentose fig receptacle 9-18 weight portion and shepherd's purse 10-30 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: fern fiber crops 14 weight portions, longflower stringbush root 32 weight portion, the coptis 26 weight portion, coix seed 40 weight portion, Radix Codonopsis 20 weight portion, ivy glorybind 32 weight portion, date 24 weight portion, pawpaw 14 weight portion, grenateleaf heteropappus herb 33 weight portion, hook catechu 20 weight portion, Herba Eragrostidis ferrugineae 35 weight portion, cardamom 32 weight portion, rock pine 22 weight portions, unpleasant swallowwort herb 36 weight portion, Cynanchum glaucescens 24 weight portion, chun spicebush root 16 weight portion, rock green onion 20 weight portion, fructus alpiniae oxyphyllae 15 weight portion, butterflybush flower 33 weight portion, cassia seed 18 weight portion, stone banyan 10 weight portion, curcuma zedoary 22 weight portion, Bulbophyllum calodictyon schlecht 33 weight portion, henry sarmentose fig receptacle 16 weight portion and shepherd's purse 20 weight portion.

The formulation of described pharmaceutical composition is powder-injection, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into the mixed powder being ground into the micron particles of 0.1～10 μm volume average particle size and particle diameter in micronizer less than the nano-scale particle composition of 0.1 μm volume average particle size, described mixed powder powder rate is at least 95%；

Second step, the ethanol that determining alcohol is 85%～95% of the quality 3 relative to described mixed powder～5 times is added in the mixed powder that the first step obtains, stirring and dissolving obtains ethanol solution, ethanol solution is stood 24～36 hours under conditions of 5 DEG C～10 DEG C, use percolation with per minute 1～2ml speed slowly diacolation, collect percolate, it is concentrated and dried, and pulverizing 40～60 minutes in micronizer are put at this, the micron particles and the particle diameter that obtain 0.1～10 μm volume average particle size are less than the mixed powder that the nano-scale particle of 0.1 μm volume average particle size forms, the powder rate that obtains of described mixed powder is at least 95%；

3rd step, takes mixed powder 10g～20g that second step obtains, and adds propane diols 30g～50g, adds 200ml water for injection, and stirring makes it dissolve, injects water to 1000ml further, add 1g～1.5g needle-use activated carbon, be sufficiently stirred for 30～50 minutes；Decarbonization filtering；With 0.22～0.24 μm filtering with microporous membrane；Freeze-drying obtains aseptic powdery, dispenses embedding.

The formulation of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

The first step, the coptis, coix seed, Radix Codonopsis, ivy glorybind, date and pawpaw are mixed in described ratio, dissolves with the ethanol that determining alcohol is 85%～95% of 3～5 times of the mixture quality relative to acquisition, extract after being heated to reflux 2～4 hours, filter, obtain the first filtered fluid；Filter residue is dissolved with the ethanol of the determining alcohol 85%～95% of 1～2 times of the mixture quality relative to acquisition again, extracts after being heated to reflux 1～2 hour, filter, obtain the second filtered fluid；Merge the first filtered fluid and the second filtered fluid, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, through the large pore resin absorption column wash-out that volume is 5L, first with deionized water or the distilled water wash-out of 5 times of resin column volumes, it is 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol eluate, reduced pressure concentration removes ethanol, is dried and is ground into powder；

Second step, unpleasant swallowwort herb, Cynanchum glaucescens, chun spicebush root, rock green onion and fructus alpiniae oxyphyllae are mixed in described ratio, add the ethanol of determining alcohol 85%～95% relative to 2～4 times of mixture quality obtained, heating and refluxing extraction 1～2 times, extract merges, being centrifuged removal of impurities with tube centrifuge, when the extract after removal of impurities is evaporated under conditions of 60 DEG C～70 DEG C 60 DEG C, relative density is the lotion of 1.20～1.23, and the lotion spray dryer after concentrating is dried to powder；

3rd step, is mixed surplus stock medicinal material in described ratio, and the water of add the mixture quality relative to acquisition 2～4 times dissolves, and heating decocts 2～4 hours, filters；Again being dissolved with the water of 1～2 times of the mixture quality relative to acquisition by filter residue, heating decocts 1～2 hour again, filters；Merging the filtered fluid of twice, reduced pressure concentration removes moisture, is dried and is ground into powder；

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, it is screened into the fine powder of 80～120 mesh subsequently, the fine powder obtained is put in mixing and blending machine and stirs, i.e. obtain powder.

The invention has the beneficial effects as follows: the invention has the beneficial effects as follows: the pharmaceutical composition of the present invention has reason spleen and stomach; strengthening the spleen and replenishing qi and effect of benefit stomach nourishing the liver; have anti-inflammatory concurrently, promote digestion and the effect of pain relieving; stomach can not only be protected, additionally it is possible to effectively regulating the immunity function of body, the course for the treatment of is shorter; curative effect is preferable; have no drug resistance, drug residue free, the advantages such as cost price is cheap.

Detailed description of the invention

The invention provides a kind of for antiemetic composition and preparation method thereof, be made up of following raw medicinal material: fern fiber crops, longflower stringbush root, the coptis, coix seed, Radix Codonopsis, Shi Rong, ivy glorybind, date, Bulbophyllum calodictyon schlecht, pawpaw, grenateleaf heteropappus herb, hook catechu, Herba Eragrostidis ferrugineae, cardamom, curcuma zedoary, rock pine, unpleasant swallowwort herb, henry sarmentose fig receptacle, Cynanchum glaucescens, chun spicebush root, rock green onion, fructus alpiniae oxyphyllae, shepherd's purse, butterflybush flower and cassia seed.

The pharmacological property of above-mentioned each raw medicinal material is as follows:

Curcuma zedoary: another name: Curcuma wenyujin, zedoary, radix zedoariae, Rhizoma Trillii Tschonoskii, smelly dung ginger.Source: this product is zingiberaceous plant zedoary Curcuma phaeocaulis Val., Guangxi zedoary Curcuma Kwangsiensis S. G.Lee et C. F. Liang or the dry rhizome of RADIX CURCUMAE Curcuma wenyujin Y.H. Chen et C. Ling.The latter practises title " Curcuma wenyujin ".Winter, cauline leaf was excavated after withering, and cleans, steams or boil to the saturating heart, dries or removes fibrous root and impurity after low temperature drying.Nature and flavor: pungent, bitter, temperature.Gui Jing: return liver, the spleen channel.Curing mainly: blood is broken in promoting the circulation of qi, disappear long-pending pain relieving.For lump in the abdomen lump in the abdomen, hemostasis through closing, dyspepsia distending pain；Early cervical carcinoma.

Cassia seed: another name: water chestnut Cassia tora, blunt leaf Cassia tora, false mung bean, Cassia occidentalis.Source: this product is the dry mature seed of legume Cassia tora Cassia obtusifolia L. or little Cassia tora Cassia tora L..Gather autumn ripening fruits, dry, lay seed, remove impurity.Nature and flavor: sweet, bitter, salty, are slightly cold.Gui Jing: return liver, large intestine channel.Cure mainly: heat-clearing improving eyesight, relax bowel.For the puckery pain of hot eyes, the many tear of photophobia, dizziness of having a headache, mesh secretly fails to understand, constipation.

Shepherd's purse: source: " not Lu ".Another name:, (" elegant "), apricot ginseng (" Bencao Tujing "), apricot leaf the root of straight ladybell, fine flour root (herbal for Relief of Famines), sweet balloonflower root (" detailed outline "), soil balloonflower root (" book on Chinese herbal medicine is original "), RADIX ADENOPHORAE (" new compilation of materia medica "), Mei Can, the root of straight ladybell that comes into leaves (" Zhejiang conventional herbal medicine among the people ").Source: for the root of Campanulaceae shepherd's purse.Nature and flavor: sweet, cold.1. " not Lu ": " sweet, cold." 2. " a thousand pieces of gold wing book on Chinese herbal medicine ": " is nontoxic." 3. " new compilation of materia medica ": " is sweet light, is slightly cold." return through: 1. " must join book on Chinese herbal medicine ": " enters meridian of Hand-TAI YIN." 2. " book on Chinese herbal medicine is looked for the truth ": " enters lung, spleen." cure mainly: heat-clearing, removing toxic substances, reduce phlegm.Control cough caused by dryness, laryngalgia, quench one's thirst, furuncle swelling toxin.

Chun spicebush root: source: Guangzhou army " conventional Chinese herbal medicine handbook ".Another name: iron wire tree (Guangzhou army " conventional Chinese herbal medicine handbook "), rake teeth hook (" Chinese Higher plant illustrated handbook ").Source: for the root of canella white glue wood.The whole year can adopt.Nature and flavor: Guangzhou army " conventional Chinese herbal medicine handbook ": " pungent, temperature." curing mainly: Guangzhou army " conventional Chinese herbal medicine handbook ": " promoting qi circulation and relieving pain, dissipates stagnation resolvation and swells.Control treating swelling and pain by traumatic injury, treating rheumatic ostealgia, flatulence."

Henry sarmentose fig receptacle: source: " Jiangxi Chinese medicine ".Another name: cliffstone pomegranate (" Illustrated Book on Plants "), Ba Lizi, precipice litchi (" Chinese tree taxology "), Shi Pengpeng (" Jiangxi Chinese medicine "), little cotton rose (" will planted by Tianmu Mountains of Zhejiang Province medicine "), len-til (Sichuan).Source: for the holder of moraceae plants pearl lotus.Gather at the beginning of winter, dry.Nature and flavor: " Jiangxi Chinese medicine ": " sweet-puckery flavor, property is put down, nontoxic." curing mainly: " Jiangxi Chinese medicine ": " controls the testis swelling and hanging down of either of the testes, internal piles, has blood in stool."

Rock pine: source: " Kunming conventional herbal medicine among the people ".Another name: Orostachys fimbriatus.Source: for crassulaceae plants chrysanthemum rock pine or the herb of safflower rock pine.Autumn gathers, and cleans, dries or using fresh herb.Nature and flavor: pungent are flat.Cure mainly: heat clearing and inflammation relieving.Control hepatitis, tympanitis, scald.

Herba Eragrostidis ferrugineae: source: begin to be loaded in " the brightest unify will ".Another name: journey stings gold.Source: medicinal material Ji Yuan: for the root of grass Herba Eragrostidis ferrugineae.Latin plant animal mineral name: Eragrostis ferruginea (Thunb) Beauv gathers and stores: August excavates, removes aerial part, cleans, dries or using fresh herb.Nature and flavor: bitter；Cool.Cure mainly: promoting blood circulation to remove blood stasis.Main internal traumatic injury；Arthralgia and myalgia.

Grenateleaf heteropappus herb: source: " Chinese herbal medicine is commonly used in Tibet ".Another name: its rice (Tibetan name).Source: for the herb of feverfew knuckle-tooth Heteropappus altaicus.7～gather August.Nature and flavor: bitter, cold.Cure mainly: detoxicating, relieving inflammation, cough-relieving.Cure cold cough, pharyngalgia, snake bite.

Rock green onion: source: " choosing of Yunnan Chinese herbal medicine ".Source: for the herb that orchid rod leaf mandarin duck tail is blue.The whole year can adopt.Using fresh herb or cut-out are dried.Nature and flavor: pungent micro-hardship, temperature.Cure mainly: anti-inflammatory, diuresis.Control fracture, traumatism and bleeding, Bai Lin.

Bulbophyllum calodictyon schlecht: source: begin to be loaded in " Xinhua's book on Chinese herbal medicine outline ".Another name: little green splendid achnatherum, U.S. Open Tennis stone beans denseflower bulbophyllum herb blue, little, Herba Bulbophylli reptantis, stone cun connect, the little stem of noble dendrobium.Source: medicinal material Ji Yuan: for the pseudobulb that the little green stone beans of orchid are blue.Latin plant animal mineral name: Bulbophyllum calodictyon Schltr. gathers and stores: summer, autumn gather, cleans, using fresh herb or dry.Nature and flavor: sweet；Flat.Gui Jing: lung；Liver；Kidney channel.Cure mainly: moisten the lung and relieve the cough；Removing toxicity for detumescence.Main pulmonary tuberculosis cough；Tracheitis；Abscess of throat；Acute mastitis；Sore swells；Traumatic injury.

Date: source: this product is the dry mature fruit of Rhamnaceae jujube jujube Ziziphus jujuba Mill. var. inermis (Bunge) Rehd..Gather during fruit maturation in autumn, dry.Its root, bark are also used as medicine, and can adopt at any time.Nature and flavor: sweet, temperature.Gui Jing: return spleen, stomach warp.Cure mainly: really (date): tonifying middle-Jiao and Qi, nourishing blood and tranquilization.Few for insufficiency of the spleen food, weak loose stool, hysteria of womam.Bark: anti-inflammatory, hemostasis, antidiarrheal.For tracheitis, enteritis, dysentery, uterine bleeding；Traumatism and bleeding is controlled in external application.Root: promoting the circulation of qi, invigorates blood circulation, menstruation regulating.For irregular menstruation, red collapse, leukorrhea.

Shi Rong: another name: great Ye banyan rattan, cliff wind, milk tree.Source: Gesneriaceae awns hair lettuce carex awns hair lettuce tongue Aeschynanthus acuminatus Wall. [A. chinensis Gardn. et Champ.], is used as medicine with complete stool or root, stem, leaf.Xia Qiu gathers, and dries.Nature and flavor: pungent, light are cool.Cure mainly: clearing heat and eliminating phlegm, inducing diuresis for removing edema, eliminating stasis and resolving masses.For bronchitis, asthma, pulmonary tuberculosis, nephritic dropsy, cancer of the stomach, cancer of the esophagus, liver cancer, breast cancer, lung cancer；Traumatic injury, burn and scald are controlled in external application, and carbuncle swells sore furuncle.

Butterflybush flower: another name: cover flower, Flos Buddlejae, always cover flower, sheep ear piece point, Shui Jinhua, chrysanthemum Lindley Butterflybush Herb.Source: this product is dry flower and the inflorescence thereof of loganiaceae plant butterflybush flower Buddleja officinalis Maxim..Spend spring when not opening and gather, remove impurity, be dried.Nature and flavor: sweet, are slightly cold.Gui Jing: return Liver Channel.Cure mainly: heat-clearing nourishing the liver, removing nebula.For red eye, swell pain, many tear photophobia, screen of looking unfamiliar film, hepatasthenia dim eyesight, blurring of vision.

Radix Rhodiolae Dumulosae: another name: phoenix-tail fern, FENGHUACAO, Sedum dumulosum.Source: Crassulaceae Rhodida plant Hericiumerinaceus Pers Rhodiola dumulosa (Franch.) Fu [Sedum dumulosum Franch.], with all herbal medicine.The whole year can adopt, and cleans and dries.Nature and flavor: hardship sweet, micro-, puckery, temperature.Cure mainly: tonifying blood and regulating menstruation, yin-nourishing.For irregular menstruation, deficiency of Yin hectic fever, have a dizzy spell, women's consumptive disease.

Coix seed: another name: Job's tears, the seed of jog's tears, seed of Job's tears, ditch rice.Source: this product is the dry mature kernal of grass Job's tears Coix lacryma-jobi L. var. ma-yuen (Roman.) Stapf.Tap plant during fruit maturation in autumn, dry, lay fruit, then dry, remove shell, yellowish-brown seed coat and impurity, collect kind of a benevolence.Nature and flavor: sweet, light are cool.Gui Jing: return spleen, stomach, lung channel.Curing mainly: invigorating the spleen excreting dampness, except numbness antidiarrheal, row is dense in heat-clearing.For oedema, tinea pedis, difficult urination, arthritis with fixed pain caused by dampness contraction, splenasthenic diarrhea, lung carbuncle, acute appendicitis；Flat wart.

Longflower stringbush root: source: " medium-height grass is commonly used in Sichuan ".Source: for the root that Isolated From Thymelaeaceae Species one is fragrant.The whole year can adopt.Nature and flavor: sweet light are flat.Cure mainly: invigorating the spleen, qi-restoratives. controlling insufficiency of the spleen stomach weak, loose stool, the deficiency of vital energy swells lingering.

Fern fiber crops: another name: panax ginseng fruit, lotus cauliflower, fruit of lengthening the life.Source: rose family potentilla plants potentilla anserina Potentilla anserina L., is used as medicine with block root.Summer excavates, and cleans and dries.Nature and flavor: sweet are flat.Cure mainly: fill blood, strengthening the spleen and stomach, promote the production of body fluid to quench thirst, dampness removing.For anaemia after being ill, malnutritive, insufficiency of the spleen diarrhoea, arthralgia due to wind-dampness.

Fructus alpiniae oxyphyllae: source: " book on Chinese herbal medicine must be joined ".Another name: intelligence development (" Kaibao Bencao "), plucks son (" Chinese medicine handbook ").Source: for the fruit of zingiberaceous plant intelligence development.5～June between pluck time fruit is brown, White flesh reduces, remove carpopodium, dry.Nature and flavor: pungent, temperature.1. " south vegetation shape ": " taste is pungent." 2. Tao Hongjing: " heat." 3. " Kaibao Bencao ": " taste is pungent, temperature, nontoxic." 4. " book on Chinese herbal medicine is just read ": " taste is worked hard, property heat." return through: enter spleen, kidney channel.1. Materia Medica of Decoction: " hand, meridian of Foot-TAI YIN, meridian of Foot-SHAO YIN." 2. " Thunder God concocts property of medicine solution ": " enters spleen, stomach, kidney three warp." 3. " book on Chinese herbal medicine is through solving ": " enters the liver channel of foot-Jueyin, lung meridian." cure mainly: temperature spleen, warm kidney, solid and gas, puckery essence.Control cold air stomachache, syncope due to pathogenic cold vomit and diarrhoea, many salivas, seminal emission, dribbling urination, night many urine.

Unpleasant swallowwort herb: source: " vegetation just side ".Another name: grandmother's sewing kit (" vegetation just side "), boneset grass, Po Poyi, suede pin (" conventional glossary of Herbs and Drugs among the people "), and radix cynanchi atrati, bamboo spirit disappear (" Traditional Chinese Medicine in Sichuan will "), dislike cynanchum auriculatum Royle ex Wight, ox horn wind, Jiu Liantai (" Shaanxi Chinese herbal medicine ").Source: for the root and rhizome (the most useful complete stool person) of peento in trailing plants section plant snow.Summer, autumn excavate, and remove aerial part, dry.Nature and flavor: pungent are flat.1. " vegetation just side ": " pungent, temperature." 2. " Shaanxi Chinese herbal medicine ": " taste is sweet micro-pungent, and property is put down." cure mainly: kidney tonifying, invigorating the spleen, change poison.Control consumptive disease to cough for a long time, edema, leukorrhea, irregular menstruation, scrofula, sore scabies.1. " vegetation just side ": " help reinforcing yin essence changes poison.The labor that cures the wound is coughed for a long time, puffiness, ulcer labor, snake, worm, mad dog wound." 2. " classifying herbal ": " pastes son of itching, and dissipates poison, logical hernia, only nosebleed, controls woman leukorrhea dizzy, painting scabies." 3. " conventional glossary of Herbs and Drugs among the people ": " relieves the pain, and detoxification controls scrofula, lactogenesis, cough-relieving." 4. " Shaanxi Chinese herbal medicine ": " enriching yin and nourishing kidney, strengthening the spleen and replenishing qi, regulating menstruation and activating blood.Control irregular menstruation, deficiency of Yin leukorrhea."

Ivy glorybind: another name: ivy glorybind herb or root, little japanese bearbind, dish intestines ginseng, floor file ginseng.Source: for Convolvulaceae calystegia plant ivy glorybind Calystegin hederacea Wall., be used as medicine with root-like stock and flower.Autumn digs root-like stock, cleans and dries or using fresh herb.Xia Qiu picks flowers using fresh herb.Nature and flavor: sweet, light are flat.Cure mainly: root-like stock: strengthening the spleen and replenishing qi, diuresis, menstruation regulating, only band；For insufficiency of the spleen indigestion, irregular menstruation, leukorrhea, milk is rare

Hook catechu: another name: bullet bavin.Source: Rhamnaceae hook fold plant hooks catechu Berchemia racemosa Sieb. et Zucc., is used as medicine with root, Gen Pi and leaf.Xia Qiucai, using fresh herb or dry.Nature and flavor: sweet, micro-puckery, tepor.Cure mainly: tonifying spleen dampness removing, stimulate the circulation of the blood and cause the muscles and joints to relax, menstruction regulating and pain relieving.Root, root skin: rheumatic arthritis, icteric hepatitis, epigastric pain, weakness of the spleen and the stomach, poor appetite, infantile malnutrition, dysmenorrhoea；Traumatic injury, acute conjunctivitis, multiple furuncle are controlled in external application.

The coptis: another name: Yun Lian, refined company, river company, taste company, Rhizoma Coptidis.Source: this product is ranunculaceae plant coptis Coptis chinensis Franch., triangle leaf coptis Coptis deltoidea C. Y. Cheng et Hsiao or cloud connect the dry rhizome of Coptis teeta Wall..Three of the above practises title " taste is even ", " refined company ", " cloud is even " respectively.Autumn excavates, and removes fibrous root and silt, is dried, and hits residual fibrous root.Nature and flavor: bitter, cold.Gui Jing: the thoughts of returning home, spleen, stomach, liver, courage, large intestine channel.Cure mainly: heat-clearing and damp-drying drug, purging intense heat and detonicating.Full for damp and hot ruffian, to vomit acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache, quenches one's thirst, and carbuncle swells furunculosis；Controlling outward eczema, wet sore, duct is suppurated.

Cardamom: another name: circle cardamom, Amomum cardamomum, purple cool, ten open cool.Source: this product is zingiberaceous plant Amomum cardamomum Amomum kravanh Pierre ex Gagnep.Or the dry mature fruit of amomum compactum Soland ex Maton Amomum compactum Soland ex Maton.It is divided into " former cardamom " and " Indonesia is the most cool " by place of production difference.Nature and flavor: pungent, temperature.Gui Jing: return lung, spleen, stomach warp.Cure mainly: dampness elimination disappears ruffian, in promoting the circulation of qi temperature, appetite-stimulating indigestion-relieving.For turbi damp obstructing in middle-JIAO, do not feel like eating, damp-warm syndrome from the beginning of, uncomfortable in chest the most hungry, cold-dampness is vomitted inverse, chest and abdomen swelling and pain, and dyspepsia does not disappears.

Cynanchum glaucescens: another name: goose pipe Cynanchum glaucescens, leaf of bamboo Cynanchum glaucescens.Source: this product is trailing plants section plant rhizoma et radix cynanchi stauntoni Cynanchum stauntonii (Decne.) Schltr. ex Levl. or the dry rhizome of leaves of Daphne genkwa Cynanchum glaucescens Cynanchum glaucescens (Decne.) Hand.-Mazz. and root.Autumn excavates, and cleans, dries.Nature and flavor: pungent, bitter, tepor.Gui Jing: return lung channel.Cure mainly: sending down abnormally ascending, dissolving phlegm, cough-relieving.Stop up real for lung qi, coughing with a lot of sputum, fullness sensation in chest breathes heavily urgency.

Pawpaw: another name: chaenomeles lagenaria, iron pin pear, wrinkled papaya, Xuancheng's pawpaw.Source: this product is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria Chaenomeles speciosa (Sweet) Nakai.Summer, season in autumn two fruit greenish-yellow time gather, put and boiling water scald to crust canescence, double vertical profile, dry.Nature and flavor: acid, temperature.Gui Jing: return liver, the spleen channel.Cure mainly: flat liver relaxing muscles and tendons, and stomach dampness elimination.For arthritis with fixed pain caused by dampness contraction, waist knee joint acid weight pain, convulsion of vomiting and diarrhoea, tinea pedis oedema.

Radix Codonopsis: another name: east party, platform party, the Lushui River party, mouth party.Source: this product is Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) Codonopsis pilosula Nannf. Var. modesta (Nannf.) L. T. Shen or the dry root of radix codonpsis tangshen Codonopsis tangshen Oliv..Autumn excavates, and cleans, dries.Nature and flavor: sweet are flat.Gui Jing: return spleen, lung channel.Cure mainly: tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung.Weak for the spleen deficiency syndrome of the lung, palpitaition of breathing hard, anorexia and loose stool, void breathes with cough and coughs, and interior heat is quenched one's thirst.

Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: fern fiber crops 10-20 weight portion, longflower stringbush root 15-35 weight portion, coptis 14-34 weight portion, coix seed 14-42 weight portion, Radix Codonopsis 11-21 weight portion, ivy glorybind 13-33 weight portion, date 15-35 weight portion, pawpaw 12-24 weight portion, grenateleaf heteropappus herb 16-34 weight portion, hook catechu 12-22 weight portion, Herba Eragrostidis ferrugineae 10-35 weight portion, cardamom 13-33 weight portion, rock pine 12-24 weight portion, unpleasant swallowwort herb 12-36 weight portion, Cynanchum glaucescens 14-28 weight portion, chun spicebush root 9-18 weight portion, rock green onion 10-23 weight portion, fructus alpiniae oxyphyllae 8-16 weight portion, butterflybush flower 13-35 weight portion and cassia seed 12-22 weight portion.

Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: fern fiber crops 14 weight portions, longflower stringbush root 32 weight portion, the coptis 26 weight portion, coix seed 40 weight portion, Radix Codonopsis 20 weight portion, ivy glorybind 32 weight portion, date 24 weight portion, pawpaw 14 weight portion, grenateleaf heteropappus herb 33 weight portion, hook catechu 20 weight portion, Herba Eragrostidis ferrugineae 35 weight portion, cardamom 32 weight portion, rock pine 22 weight portions, unpleasant swallowwort herb 36 weight portion, Cynanchum glaucescens 24 weight portion, chun spicebush root 16 weight portion, rock green onion 20 weight portion, fructus alpiniae oxyphyllae 15 weight portion, butterflybush flower 33 weight portion and cassia seed 18 weight portion.

In described pharmaceutical composition, each raw medicinal material also includes: Shi Rong, curcuma zedoary, Bulbophyllum calodictyon schlecht, henry sarmentose fig receptacle and shepherd's purse.

nullIn described pharmaceutical composition, the parts by weight of each raw medicinal material are: fern fiber crops 10-20 weight portion、Longflower stringbush root 15-35 weight portion、Coptis 14-34 weight portion、Coix seed 14-42 weight portion、Radix Codonopsis 11-21 weight portion、Ivy glorybind 13-33 weight portion、Date 15-35 weight portion、Pawpaw 12-24 weight portion、Grenateleaf heteropappus herb 16-34 weight portion、Hook catechu 12-22 weight portion、Herba Eragrostidis ferrugineae 10-35 weight portion、Cardamom 13-33 weight portion、Rock pine 12-24 weight portion、Unpleasant swallowwort herb 12-36 weight portion、Cynanchum glaucescens 14-28 weight portion、Chun spicebush root 9-18 weight portion、Rock green onion 10-23 weight portion、Fructus alpiniae oxyphyllae 8-16 weight portion、Butterflybush flower 13-35 weight portion、Cassia seed 12-22 weight portion、Stone banyan 7-14 weight portion、Curcuma zedoary 10-22 weight portion、Bulbophyllum calodictyon schlecht 12-34 weight portion、Henry sarmentose fig receptacle 9-18 weight portion and shepherd's purse 10-30 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: fern fiber crops 14 weight portions, longflower stringbush root 32 weight portion, the coptis 26 weight portion, coix seed 40 weight portion, Radix Codonopsis 20 weight portion, ivy glorybind 32 weight portion, date 24 weight portion, pawpaw 14 weight portion, grenateleaf heteropappus herb 33 weight portion, hook catechu 20 weight portion, Herba Eragrostidis ferrugineae 35 weight portion, cardamom 32 weight portion, rock pine 22 weight portions, unpleasant swallowwort herb 36 weight portion, Cynanchum glaucescens 24 weight portion, chun spicebush root 16 weight portion, rock green onion 20 weight portion, fructus alpiniae oxyphyllae 15 weight portion, butterflybush flower 33 weight portion, cassia seed 18 weight portion, stone banyan 10 weight portion, curcuma zedoary 22 weight portion, Bulbophyllum calodictyon schlecht 33 weight portion, henry sarmentose fig receptacle 16 weight portion and shepherd's purse 20 weight portion.

The formulation of described pharmaceutical composition is powder-injection, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into the mixed powder being ground into the micron particles of 0.1～10 μm volume average particle size and particle diameter in micronizer less than the nano-scale particle composition of 0.1 μm volume average particle size, described mixed powder powder rate is at least 95%；

Second step, the ethanol that determining alcohol is 85%～95% of the quality 3 relative to described mixed powder～5 times is added in the mixed powder that the first step obtains, stirring and dissolving obtains ethanol solution, ethanol solution is stood 24～36 hours under conditions of 5 DEG C～10 DEG C, use percolation with per minute 1～2ml speed slowly diacolation, collect percolate, it is concentrated and dried, and pulverizing 40～60 minutes in micronizer are put at this, the micron particles and the particle diameter that obtain 0.1～10 μm volume average particle size are less than the mixed powder that the nano-scale particle of 0.1 μm volume average particle size forms, the powder rate that obtains of described mixed powder is at least 95%；

3rd step, takes mixed powder 10g～20g that second step obtains, and adds propane diols 30g～50g, adds 200ml water for injection, and stirring makes it dissolve, injects water to 1000ml further, add 1g～1.5g needle-use activated carbon, be sufficiently stirred for 30～50 minutes；Decarbonization filtering；With 0.22～0.24 μm filtering with microporous membrane；Freeze-drying obtains aseptic powdery, dispenses embedding.

The formulation of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

The first step, the coptis, coix seed, Radix Codonopsis, ivy glorybind, date and pawpaw are mixed in described ratio, dissolves with the ethanol that determining alcohol is 85%～95% of 3～5 times of the mixture quality relative to acquisition, extract after being heated to reflux 2～4 hours, filter, obtain the first filtered fluid；Filter residue is dissolved with the ethanol of the determining alcohol 85%～95% of 1～2 times of the mixture quality relative to acquisition again, extracts after being heated to reflux 1～2 hour, filter, obtain the second filtered fluid；Merge the first filtered fluid and the second filtered fluid, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, through the large pore resin absorption column wash-out that volume is 5L, first with deionized water or the distilled water wash-out of 5 times of resin column volumes, it is 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol eluate, reduced pressure concentration removes ethanol, is dried and is ground into powder；

Second step, unpleasant swallowwort herb, Cynanchum glaucescens, chun spicebush root, rock green onion and fructus alpiniae oxyphyllae are mixed in described ratio, add the ethanol of determining alcohol 85%～95% relative to 2～4 times of mixture quality obtained, heating and refluxing extraction 1～2 times, extract merges, being centrifuged removal of impurities with tube centrifuge, when the extract after removal of impurities is evaporated under conditions of 60 DEG C～70 DEG C 60 DEG C, relative density is the lotion of 1.20～1.23, and the lotion spray dryer after concentrating is dried to powder；

3rd step, is mixed surplus stock medicinal material in described ratio, and the water of add the mixture quality relative to acquisition 2～4 times dissolves, and heating decocts 2～4 hours, filters；Again being dissolved with the water of 1～2 times of the mixture quality relative to acquisition by filter residue, heating decocts 1～2 hour again, filters；Merging the filtered fluid of twice, reduced pressure concentration removes moisture, is dried and is ground into powder；

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, it is screened into the fine powder of 80～120 mesh subsequently, the fine powder obtained is put in mixing and blending machine and stirs, i.e. obtain powder.

Hereinafter using embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.

Embodiment 1 pharmaceutical composition 1

Embodiments provide a kind of pharmaceutical composition for antiemetic, it is made up of the raw medicinal material of following parts by weight: fern fiber crops 14 weight portions, longflower stringbush root 32 weight portion, the coptis 26 weight portion, coix seed 40 weight portion, Radix Codonopsis 20 weight portion, ivy glorybind 32 weight portion, date 24 weight portion, pawpaw 14 weight portion, grenateleaf heteropappus herb 33 weight portion, hook catechu 20 weight portion, Herba Eragrostidis ferrugineae 35 weight portion, cardamom 32 weight portion, rock pine 22 weight portions, unpleasant swallowwort herb 36 weight portion, Cynanchum glaucescens 24 weight portion, chun spicebush root 16 weight portion, rock green onion 20 weight portion, fructus alpiniae oxyphyllae 15 weight portion, butterflybush flower 33 weight portion and cassia seed 18 weight portion；

Its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into the mixed powder being ground into the micron particles of 3 μm volume average particle size and particle diameter in micronizer less than the nano-scale particle composition of 0.1 μm volume average particle size, described mixed powder powder rate is at least 95%；

Second step, the ethanol that determining alcohol is 90% of the quality 4 times relative to described mixed powder is added in the mixed powder that the first step obtains, stirring and dissolving obtains ethanol solution, ethanol solution is stood 30 hours under conditions of 9 DEG C, use percolation with the speed slowly diacolation of 2ml per minute, collect percolate, it is concentrated and dried, and pulverizing 50 minutes in micronizer are put at this, the micron particles and the particle diameter that obtain 4 μm volume average particle size are less than the mixed powder that the nano-scale particle of 0.1 μm volume average particle size forms, the powder rate that obtains of described mixed powder is at least 95%；

3rd step, takes the mixed powder 15g that second step obtains, and adds propane diols 40g, adds 200ml water for injection, and stirring makes it dissolve, injects water to 1000ml further, add 1.5g needle-use activated carbon, be sufficiently stirred for 40 minutes；Decarbonization filtering；With 0.23 μm filtering with microporous membrane；Freeze-drying obtains aseptic powdery, dispenses embedding.

Embodiment 2 pharmaceutical composition 2

Embodiments provide a kind of pharmaceutical composition for antiemetic, it is made up of the raw medicinal material of following parts by weight: fern fiber crops 14 weight portions, longflower stringbush root 32 weight portion, the coptis 26 weight portion, coix seed 40 weight portion, Radix Codonopsis 20 weight portion, ivy glorybind 32 weight portion, date 24 weight portion, pawpaw 14 weight portion, grenateleaf heteropappus herb 33 weight portion, hook catechu 20 weight portion, Herba Eragrostidis ferrugineae 35 weight portion, cardamom 32 weight portion, rock pine 22 weight portions, unpleasant swallowwort herb 36 weight portion, Cynanchum glaucescens 24 weight portion, chun spicebush root 16 weight portion, rock green onion 20 weight portion, fructus alpiniae oxyphyllae 15 weight portion, butterflybush flower 33 weight portion, cassia seed 18 weight portion, stone banyan 10 weight portion, curcuma zedoary 22 weight portion, Bulbophyllum calodictyon schlecht 33 weight portion, henry sarmentose fig receptacle 16 weight portion and shepherd's purse 20 weight portion；

Its preparation method is as follows:

The first step, is mixed the coptis, coix seed, Radix Codonopsis, ivy glorybind, date and pawpaw in described ratio, dissolves with the ethanol that determining alcohol is 90% of 4 times of the mixture quality relative to acquisition, extracts after being heated to reflux 3 hours, filters, obtain the first filtered fluid；Filter residue is dissolved with the ethanol of the determining alcohol 85% of 1.5 times of the mixture quality relative to acquisition again, extracts after being heated to reflux 2 hours, filter, obtain the second filtered fluid；Merge the first filtered fluid and the second filtered fluid, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, through the large pore resin absorption column wash-out that volume is 5L, first with deionized water or the distilled water wash-out of 5 times of resin column volumes, it is 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol eluate, reduced pressure concentration removes ethanol, is dried and is ground into powder；

Second step, unpleasant swallowwort herb, Cynanchum glaucescens, chun spicebush root, rock green onion and fructus alpiniae oxyphyllae are mixed in described ratio, add the ethanol of determining alcohol 90% relative to 3 times of mixture quality obtained, heating and refluxing extraction 2 times, extract merges, being centrifuged removal of impurities with tube centrifuge, it is the lotion of 1.22 that the extract after removal of impurities is evaporated under conditions of 65 DEG C relative density when 60 DEG C, and the lotion spray dryer after concentrating is dried to powder；

3rd step, is mixed surplus stock medicinal material in described ratio, and the water of add the mixture quality relative to acquisition 3 times dissolves, and heating decocts 4 hours, filters；Again being dissolved with the water of 1.5 times of the mixture quality relative to acquisition by filter residue, heating decocts 2 hours again, filters；Merging the filtered fluid of twice, reduced pressure concentration removes moisture, is dried and is ground into powder；

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, it is screened into the fine powder of 100 mesh subsequently, the fine powder obtained is put in mixing and blending machine and stirs, i.e. obtain powder.

The toxicity test of pharmaceutical composition:

1, trial drug composition

Choose fern fiber crops 14g, longflower stringbush root 32g, coptis 26g, coix seed 40g, Radix Codonopsis 20g, ivy glorybind 32g, date 24g, pawpaw 14g, grenateleaf heteropappus herb 33g, hook catechu 20g, Herba Eragrostidis ferrugineae 35g, cardamom 32g, rock pine 22g, unpleasant swallowwort herb 36g, Cynanchum glaucescens 24g, chun spicebush root 16g, rock green onion 20g, fructus alpiniae oxyphyllae 15g, butterflybush flower 33g and cassia seed 18g mixing, be ground into powder；To obtain powder and add immersion 25 hours in 1400g cold water, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, it is thus achieved that the first filtrate, collects filter residue；Again add in 1400g cold water by filtering the filter residue obtained, with slow fire boiling 3 times, decoct 1 hour every time, filter and merge filtered fluid, it is thus achieved that the second filtrate；Merging twice filtrate, reduced pressure concentration removes part water, it is thus achieved that decoction, the crude drug concentration of decoction is 3g/ml.

2, test method: select SD rat, give the decoction of the pharmaceutical composition of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, last is administered latter 24 hours respectively to organize to live and kills 1/2 animal (male and female half and half), and remaining 1/2 animal lives after continuing to observe 2 weeks and kills.Observe the outward appearance of animal, general behavior, food ration, changes of weight during test, be administered latter 90 days and drug withdrawal carries out the index checking such as hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, Histopathology for 2 weeks.Result of the test shows: the pharmaceutical composition of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change the most without exception； Three dosage groups and control group hematological examination, blood biochemical analysis, urine biochemical analysis all between normal range (NR), group without significant difference；Each group main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively the 180 of clinical medicine dose, 60,20 times, pharmaceutical composition according to the result of the test present invention is administered at high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) and has no significant effect rat for continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescence observes and also has no retardance toxic reaction, and the dose safety of the pharmaceutical composition clinical practice of the prompting present invention is higher.

Contrast test

In July ,-2014 in July, 2013,400 domestic cats are had to suffer from vomiting, 300 cats are randomly divided into three groups, it is respectively embodiment 1 group, embodiment 2 groups and western medicine group, the pharmaceutical composition 2 using pharmaceutical composition 1 that embodiment 1 prepares, embodiment 2 to prepare respectively carries out treating and conventional medicament is treated, wherein, the dose of embodiment 1-2 group be every every day 0.3g, be 10-20 days during treatment；The conventional medicament of western medicine group selects irolapride 10mg/mL to carry out neck injection, every day 1 time, treats 10-20 days.Treatment is observed three months after terminating, and records cure rate and the death rate of each group of cat, and result is as shown in table 1.

Table 1 each experimental group result for the treatment of table of comparisons

Group	Ill cat number (only)	Death toll	The death rate	Cure number	Cure rate
						Embodiment 1 group	100	2%	2%	98	98%
Embodiment 2 groups	100	0%	0%	100	100%
						Western medicine group	100	24%	24%	76	76%

Knowable to the data of table 1: medicine of the present invention is substantially better than western medicine group to the result for the treatment of that cat vomits, reduce the death rate, improve cure rate.

The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.

Claims (10)

1. the pharmaceutical composition for antiemetic, it is characterized in that, described pharmaceutical composition includes being made up of following raw medicinal material: fern fiber crops, longflower stringbush root, the coptis, coix seed, Radix Codonopsis, ivy glorybind, date, pawpaw, grenateleaf heteropappus herb, hook catechu, Herba Eragrostidis ferrugineae, cardamom, rock pine, unpleasant swallowwort herb, Cynanchum glaucescens, chun spicebush root, rock green onion, fructus alpiniae oxyphyllae, butterflybush flower and cassia seed.

nullPharmaceutical composition for antiemetic the most according to claim 1，It is characterized in that，Described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: fern fiber crops 10-20 weight portion、Longflower stringbush root 15-35 weight portion、Coptis 14-34 weight portion、Coix seed 14-42 weight portion、Radix Codonopsis 11-21 weight portion、Ivy glorybind 13-33 weight portion、Date 15-35 weight portion、Pawpaw 12-24 weight portion、Grenateleaf heteropappus herb 16-34 weight portion、Hook catechu 12-22 weight portion、Herba Eragrostidis ferrugineae 10-35 weight portion、Cardamom 13-33 weight portion、Rock pine 12-24 weight portion、Unpleasant swallowwort herb 12-36 weight portion、Cynanchum glaucescens 14-28 weight portion、Chun spicebush root 9-18 weight portion、Rock green onion 10-23 weight portion、Fructus alpiniae oxyphyllae 8-16 weight portion、Butterflybush flower 13-35 weight portion and cassia seed 12-22 weight portion.

Pharmaceutical composition for antiemetic the most according to claim 1 and 2, it is characterized in that, described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: fern fiber crops 14 weight portions, longflower stringbush root 32 weight portion, the coptis 26 weight portion, coix seed 40 weight portion, Radix Codonopsis 20 weight portion, ivy glorybind 32 weight portion, date 24 weight portion, pawpaw 14 weight portion, grenateleaf heteropappus herb 33 weight portion, hook catechu 20 weight portion, Herba Eragrostidis ferrugineae 35 weight portion, cardamom 32 weight portion, rock pine 22 weight portions, unpleasant swallowwort herb 36 weight portion, Cynanchum glaucescens 24 weight portion, chun spicebush root 16 weight portion, rock green onion 20 weight portion, fructus alpiniae oxyphyllae 15 weight portion, butterflybush flower 33 weight portion and cassia seed 18 weight portion.

4. according to the pharmaceutical composition for antiemetic described in any one of claim 1-3, it is characterised in that in described pharmaceutical composition, each raw medicinal material also includes: Shi Rong, curcuma zedoary, Bulbophyllum calodictyon schlecht, henry sarmentose fig receptacle and shepherd's purse.

null5. according to the pharmaceutical composition for antiemetic described in any one of claim 1-4，It is characterized in that，In described pharmaceutical composition, the parts by weight of each raw medicinal material are: fern fiber crops 10-20 weight portion、Longflower stringbush root 15-35 weight portion、Coptis 14-34 weight portion、Coix seed 14-42 weight portion、Radix Codonopsis 11-21 weight portion、Ivy glorybind 13-33 weight portion、Date 15-35 weight portion、Pawpaw 12-24 weight portion、Grenateleaf heteropappus herb 16-34 weight portion、Hook catechu 12-22 weight portion、Herba Eragrostidis ferrugineae 10-35 weight portion、Cardamom 13-33 weight portion、Rock pine 12-24 weight portion、Unpleasant swallowwort herb 12-36 weight portion、Cynanchum glaucescens 14-28 weight portion、Chun spicebush root 9-18 weight portion、Rock green onion 10-23 weight portion、Fructus alpiniae oxyphyllae 8-16 weight portion、Butterflybush flower 13-35 weight portion、Cassia seed 12-22 weight portion、Stone banyan 7-14 weight portion、Curcuma zedoary 10-22 weight portion、Bulbophyllum calodictyon schlecht 12-34 weight portion、Henry sarmentose fig receptacle 9-18 weight portion and shepherd's purse 10-30 weight portion.

null6. according to the pharmaceutical composition for antiemetic described in any one of claim 1-5，It is characterized in that，In described pharmaceutical composition, the parts by weight of each raw medicinal material are: fern fiber crops 14 weight portions、Longflower stringbush root 32 weight portion、The coptis 26 weight portion、Coix seed 40 weight portion、Radix Codonopsis 20 weight portion、Ivy glorybind 32 weight portion、Date 24 weight portion、Pawpaw 14 weight portion、Grenateleaf heteropappus herb 33 weight portion、Hook catechu 20 weight portion、Herba Eragrostidis ferrugineae 35 weight portion、Cardamom 32 weight portion、Rock pine 22 weight portions、Unpleasant swallowwort herb 36 weight portion、Cynanchum glaucescens 24 weight portion、Chun spicebush root 16 weight portion、Rock green onion 20 weight portion、Fructus alpiniae oxyphyllae 15 weight portion、Butterflybush flower 33 weight portion、Cassia seed 18 weight portion、Stone banyan 10 weight portion、Curcuma zedoary 22 weight portion、Bulbophyllum calodictyon schlecht 33 weight portion、Henry sarmentose fig receptacle 16 weight portion and shepherd's purse 20 weight portion.

7. according to the pharmaceutical composition for antiemetic described in any one of claim 1-6, it is characterised in that the formulation of described pharmaceutical composition is powder-injection, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into the mixed powder being ground into the micron particles of 0.1～10 μm volume average particle size and particle diameter in micronizer less than the nano-scale particle composition of 0.1 μm volume average particle size, described mixed powder powder rate is at least 95%；

Second step, the ethanol that determining alcohol is 85%～95% of the quality 3 relative to described mixed powder～5 times is added in the mixed powder that the first step obtains, stirring and dissolving obtains ethanol solution, ethanol solution is stood 24～36 hours under conditions of 5 DEG C～10 DEG C, use percolation with per minute 1～2ml speed slowly diacolation, collect percolate, it is concentrated and dried, and pulverizing 40～60 minutes in micronizer are put at this, the micron particles and the particle diameter that obtain 0.1～10 μm volume average particle size are less than the mixed powder that the nano-scale particle of 0.1 μm volume average particle size forms, the powder rate that obtains of described mixed powder is at least 95%；

3rd step, takes mixed powder 10g～20g that second step obtains, and adds propane diols 30g～50g, adds 200ml water for injection, and stirring makes it dissolve, injects water to 1000ml further, add 1g～1.5g needle-use activated carbon, be sufficiently stirred for 30～50 minutes；Decarbonization filtering；With 0.22～0.24 μm filtering with microporous membrane；Freeze-drying obtains aseptic powdery, dispenses embedding.

8. according to the pharmaceutical composition for antiemetic described in any one of claim 1-6, it is characterised in that the formulation of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

The first step, the coptis, coix seed, Radix Codonopsis, ivy glorybind, date and pawpaw are mixed in described ratio, dissolves with the ethanol that determining alcohol is 85%～95% of 3～5 times of the mixture quality relative to acquisition, extract after being heated to reflux 2～4 hours, filter, obtain the first filtered fluid；Filter residue is dissolved with the ethanol of the determining alcohol 85%～95% of 1～2 times of the mixture quality relative to acquisition again, extracts after being heated to reflux 1～2 hour, filter, obtain the second filtered fluid；Merge the first filtered fluid and the second filtered fluid, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, through the large pore resin absorption column wash-out that volume is 5L, first with deionized water or the distilled water wash-out of 5 times of resin column volumes, it is 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol eluate, reduced pressure concentration removes ethanol, is dried and is ground into powder；

Second step, unpleasant swallowwort herb, Cynanchum glaucescens, chun spicebush root, rock green onion and fructus alpiniae oxyphyllae are mixed in described ratio, add the ethanol of determining alcohol 85%～95% relative to 2～4 times of mixture quality obtained, heating and refluxing extraction 1～2 times, extract merges, being centrifuged removal of impurities with tube centrifuge, when the extract after removal of impurities is evaporated under conditions of 60 DEG C～70 DEG C 60 DEG C, relative density is the lotion of 1.20～1.23, and the lotion spray dryer after concentrating is dried to powder；

3rd step, is mixed surplus stock medicinal material in described ratio, and the water of add the mixture quality relative to acquisition 2～4 times dissolves, and heating decocts 2～4 hours, filters；Again being dissolved with the water of 1～2 times of the mixture quality relative to acquisition by filter residue, heating decocts 1～2 hour again, filters；Merging the filtered fluid of twice, reduced pressure concentration removes moisture, is dried and is ground into powder；

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, it is screened into the fine powder of 80～120 mesh subsequently, the fine powder obtained is put in mixing and blending machine and stirs, i.e. obtain powder.

9. according to the pharmaceutical composition for antiemetic described in any one of claim 1-6, it is characterised in that the formulation of described pharmaceutical composition is powder-injection, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into the mixed powder being ground into the micron particles of 0.1～10 μm volume average particle size and particle diameter in micronizer less than the nano-scale particle composition of 0.1 μm volume average particle size, described mixed powder powder rate is at least 95%；

Second step, the ethanol that determining alcohol is 85%～95% of the quality 3 relative to described mixed powder～5 times is added in the mixed powder that the first step obtains, stirring and dissolving obtains ethanol solution, ethanol solution is stood 24～36 hours under conditions of 5 DEG C～10 DEG C, use percolation with per minute 1～2ml speed slowly diacolation, collect percolate, it is concentrated and dried, and pulverizing 40～60 minutes in micronizer are put at this, the micron particles and the particle diameter that obtain 0.1～10 μm volume average particle size are less than the mixed powder that the nano-scale particle of 0.1 μm volume average particle size forms, the powder rate that obtains of described mixed powder is at least 95%；

3rd step, takes mixed powder 10g～20g that second step obtains, and adds propane diols 30g～50g, adds 200ml water for injection, and stirring makes it dissolve, injects water to 1000ml further, add 1g～1.5g needle-use activated carbon, be sufficiently stirred for 30～50 minutes；Decarbonization filtering；With 0.22～0.24 μm filtering with microporous membrane；Freeze-drying obtains aseptic powdery, dispenses embedding.

10. the preparation method of the pharmaceutical composition for antiemetic as described in any one of claim 1-6, it is characterised in that the formulation of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

The first step, the coptis, coix seed, Radix Codonopsis, ivy glorybind, date and pawpaw are mixed in described ratio, dissolves with the ethanol that determining alcohol is 85%～95% of 3～5 times of the mixture quality relative to acquisition, extract after being heated to reflux 2～4 hours, filter, obtain the first filtered fluid；Filter residue is dissolved with the ethanol of the determining alcohol 85%～95% of 1～2 times of the mixture quality relative to acquisition again, extracts after being heated to reflux 1～2 hour, filter, obtain the second filtered fluid；Merge the first filtered fluid and the second filtered fluid, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, through the large pore resin absorption column wash-out that volume is 5L, first with deionized water or the distilled water wash-out of 5 times of resin column volumes, it is 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol eluate, reduced pressure concentration removes ethanol, is dried and is ground into powder；

Second step, unpleasant swallowwort herb, Cynanchum glaucescens, chun spicebush root, rock green onion and fructus alpiniae oxyphyllae are mixed in described ratio, add the ethanol of determining alcohol 85%～95% relative to 2～4 times of mixture quality obtained, heating and refluxing extraction 1～2 times, extract merges, being centrifuged removal of impurities with tube centrifuge, when the extract after removal of impurities is evaporated under conditions of 60 DEG C～70 DEG C 60 DEG C, relative density is the lotion of 1.20～1.23, and the lotion spray dryer after concentrating is dried to powder；

3rd step, is mixed surplus stock medicinal material in described ratio, and the water of add the mixture quality relative to acquisition 2～4 times dissolves, and heating decocts 2～4 hours, filters；Again being dissolved with the water of 1～2 times of the mixture quality relative to acquisition by filter residue, heating decocts 1～2 hour again, filters；Merging the filtered fluid of twice, reduced pressure concentration removes moisture, is dried and is ground into powder；

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, it is screened into the fine powder of 80～120 mesh subsequently, the fine powder obtained is put in mixing and blending machine and stirs, i.e. obtain powder.