CN105853561A - Candicidin dermatitis ointment and preparing method thereof - Google Patents

Candicidin dermatitis ointment and preparing method thereof Download PDF

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Publication number
CN105853561A
CN105853561A CN201610363236.0A CN201610363236A CN105853561A CN 105853561 A CN105853561 A CN 105853561A CN 201610363236 A CN201610363236 A CN 201610363236A CN 105853561 A CN105853561 A CN 105853561A
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consumption
weight portion
candicidin
chinese herbal
herbal medicine
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苏福男
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WUHU FOMAN BIOPHARMA Co Ltd
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WUHU FOMAN BIOPHARMA Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention discloses a candicidin dermatitis ointment and a preparing method thereof. The preparing method comprises the steps of 1, decocting Chinese herbal medicines in water, and conducting filtration to obtain Chinese herbal medicine extracting solution; 2, mixing vaseline, liquid paraffin, candicidin, metronidazole, tanshinone, sal ammoniac, realgar, sulphur, dimethyl sulfoxide and the Chinese herbal medicine extracting solution to prepare the candicidin dermatitis ointment, wherein Chinese herbal medicines include herb of shady jerusalemsage, citrus chirocarpus, gambir plant, licorice root, gecko, Chinese prickly ash, fructus chebulae, honeysuckle flower, rhizoma coptidis, radix scutellariae, cortex phellodendri and calculus bovis. The candicidin dermatitis ointment prepared with the method is high in dermatitis cure rate, short in cure period and low in relapse rate.

Description

Candicidin dermatitis ointment and preparation method thereof
Technical field
The present invention relates to dermatitis ointment, in particular it relates to a kind of candicidin dermatitis ointment and preparation side thereof Method.
Background technology
Dermatitis and eczema are used to refer to a kind of scytitis frequently as synonym, represent skin for chemistry system The allergic reaction of all materials such as agent, albumen, bacterium and fungi.The pathogenic factor of dermatitis and eczema is very Complexity, is simply divided into internal factor and external factor, therebetween difficult point of primary and secondary, it is common that be connected mutually System, synergy；External cause such as chemicals, cosmetics, zootoxin, fishes and shrimps, pollen, dust, Exposure to Sunlight and scratching, internal cause includes inherent cause, mental element, the immune factor of body and metabolic factor Deng.The impact of dermatitis and eczema is increasingly come into one's own by psychological factor, the generation of dermatitis and eczema It is also possible to there is certain relation with diet, rule of life and environment etc..
At present, the medicine of dermatitis and eczema can be divided into Western medicine and Chinese medicine, and the drug effect of Western medicine is fast, but Dermatitis and eczema easily recurs, the drug effect slow-motion of Chinese medicine and cause treatment cycle long, but it is low to control recurrence rate after healing. It can thus be seen that either all there is certain defect in Western medicine or Chinese medicine.
Summary of the invention
It is an object of the invention to provide a kind of candicidin dermatitis ointment and preparation method thereof, pass through the method The candicidin dermatitis ointment prepared is high to the cure rate of dermatitis, the healing cycle is short and recurrence rate is low.
To achieve these goals, the invention provides the preparation method of a kind of candicidin dermatitis ointment, Including:
1) carry out Chinese herbal medicine in water decocting, filtering prepared extracts of Chinese herbal medicine；
2) by vaseline, liquid paraffin, candicidin, metronidazole, tanshinone, sal ammoniac, realgar, Sulphur, dimethyl alum and extracts of Chinese herbal medicine are mixed to prepare candicidin dermatitis ointment；
Wherein, Chinese herbal medicine contains phlomis umbrosa, Buddha's hand, yncaria stem with hooks, Radix Glycyrrhizae, gecko, Chinese prickly ash, myrobalan, gold and silver Flower, the coptis, the root of large-flowered skullcap, golden cypress and cow-bezoar.
Present invention also offers a kind of candicidin dermatitis ointment, this candicidin dermatitis ointment is by above-mentioned Method be prepared.
By technique scheme, the present invention is by each component in above-mentioned preparation method and each step Synergy make that the drug effect of candicidin dermatitis ointment prepared is fast, cure rate is high, the healing cycle is short and Recurrence rate is low, thus overcomes the respective defect of prior art Chinese and Western medicine, Chinese medicine, and then improves dermatitis The result for the treatment of of eczema.
Other features and advantages of the present invention will be described in detail in detailed description of the invention part subsequently.
Detailed description of the invention
Hereinafter the detailed description of the invention of the present invention is described in detail.It should be appreciated that this place is retouched The detailed description of the invention stated is merely to illustrate and explains the present invention, is not limited to the present invention.
The invention provides the preparation method of a kind of candicidin dermatitis ointment, including:
1) carry out Chinese herbal medicine in water decocting, filtering prepared extracts of Chinese herbal medicine；
2) by vaseline, liquid paraffin, candicidin, metronidazole, tanshinone, sal ammoniac, realgar, Sulphur, dimethyl alum and extracts of Chinese herbal medicine are mixed to prepare candicidin dermatitis ointment；
Wherein, Chinese herbal medicine contains phlomis umbrosa, Buddha's hand, yncaria stem with hooks, Radix Glycyrrhizae, gecko, Chinese prickly ash, myrobalan, gold and silver Flower, the coptis, the root of large-flowered skullcap, golden cypress and cow-bezoar.
Step 1 in the present invention) in, the consumption of Chinese herbal medicine can select in wide scope, but is Improve the drug effect of candicidin dermatitis ointment, cure rate, healing cycle and the recurrence rate prepared；Preferably Ground, relative to the phlomis umbrosa of 100 weight portions, the consumption of Buddha's hand is 37-44 weight portion, and the consumption of yncaria stem with hooks is 44-65 weight portion, the consumption of Radix Glycyrrhizae is 10-22 weight portion, and the consumption of gecko is 55-62 weight portion, flower The consumption of green pepper is 34-47 weight portion, and the consumption of myrobalan is 65-74 weight portion, and the consumption of honeysuckle is 60-84 Weight portion, the consumption of the coptis is 45-60 weight portion, and the consumption of the root of large-flowered skullcap is 47-58 weight portion, golden cypress Consumption is 33-42 weight portion, and the consumption of cow-bezoar is 5-9 weight portion.
Step 1 in the present invention) in, the consumption of water can select in wide scope, but in order to carry The high drug effect of candicidin dermatitis ointment, cure rate, healing cycle and the recurrence rate prepared；Preferably, Relative to the described phlomis umbrosa of 100 weight portions, the consumption of described water is 500-800 weight portion.
Step 1 in the present invention) in, the actual conditions of decoction can select in wide scope, but In order to improve the prepared drug effect of candicidin dermatitis ointment, cure rate, healing cycle and recurrence rate；Excellent Selection of land, decocts and at least meets following condition: decocting temperature and be 110-130 DEG C, decocting time is 3-5h.
Step 2 in the present invention) in, the consumption of each material can select in wide scope, but is Improve the drug effect of candicidin dermatitis ointment, cure rate, healing cycle and the recurrence rate prepared；Preferably Ground, in step 2) in, relative to the vaseline of 100 weight portions, the consumption of liquid paraffin is 47-60 Weight portion, the consumption of candicidin is 15-24 weight portion, and the consumption of metronidazole is 22-34 weight portion, The consumption of tanshinone is 9-18 weight portion, and the consumption of sal ammoniac is 3-7 weight portion, and the consumption of realgar is 8-15 Weight portion, the consumption of sulphur is 4-8 weight portion, and the consumption of dimethyl alum is 35-47 weight portion, in The consumption of herbal medicine extract is 14-20 weight portion.
In order to improve further the prepared drug effect of candicidin dermatitis ointment, cure rate, the healing cycle and Recurrence rate, it is preferable that before decocting, the method also includes that Chinese herbal medicine is placed in water soaks.This Sample can improve the recovery rate of active ingredient in Chinese herbal medicine as much as possible by the method soaked.
In above-mentioned immersion process, the actual conditions of immersion can select in wide scope, but in order to Improve the drug effect of candicidin dermatitis ointment, cure rate, healing cycle and the recurrence rate prepared；Preferably, Soak and at least meet following condition: soaking temperature is 25-35 DEG C, and soak time is 24-30h.
Present invention also offers a kind of candicidin dermatitis ointment, this candicidin dermatitis ointment is by above-mentioned Method be prepared.
Hereinafter will be described the present invention by embodiment.
Embodiment 1
1) by phlomis umbrosa, Buddha's hand, yncaria stem with hooks, Radix Glycyrrhizae, gecko, Chinese prickly ash, myrobalan, honeysuckle, the coptis, The root of large-flowered skullcap, golden cypress, cow-bezoar and water are according to 100:42:55:17:58:39:68:72:48:55: Mixed being incorporated at 120 DEG C of the weight ratio of 38:7:600 carries out decocting 4h, filtering prepared extracts of Chinese herbal medicine；
2) at 25 DEG C, by vaseline, liquid paraffin, candicidin, metronidazole, tanshinone, Nao Sand, realgar, sulphur, dimethyl alum and extracts of Chinese herbal medicine are according to 100:50:18:29:14:5: The weight ratio mixing 30min of 10:7:41:18 prepares candicidin dermatitis ointment A1.
Embodiment 2
1) by phlomis umbrosa, Buddha's hand, yncaria stem with hooks, Radix Glycyrrhizae, gecko, Chinese prickly ash, myrobalan, honeysuckle, the coptis, The root of large-flowered skullcap, golden cypress, cow-bezoar and water are according to 100:37:44:10:55:34:65:60:45:47: Mixed being incorporated at 110 DEG C of the weight ratio of 33:5:500 carries out decocting 3h, filtering prepared extracts of Chinese herbal medicine；
2) at 25 DEG C, by vaseline, liquid paraffin, candicidin, metronidazole, tanshinone, Nao Sand, realgar, sulphur, dimethyl alum and extracts of Chinese herbal medicine are according to 100:47:15:22:9:3: The weight ratio mixing 30min of 8:4:35:14 prepares candicidin dermatitis ointment A2.
Embodiment 3
1) by phlomis umbrosa, Buddha's hand, yncaria stem with hooks, Radix Glycyrrhizae, gecko, Chinese prickly ash, myrobalan, honeysuckle, the coptis, The root of large-flowered skullcap, golden cypress, cow-bezoar and water are according to 100:44:65:22:62:47:74:84:60:58: Mixed being incorporated at 130 DEG C of the weight ratio of 42:9:800 carries out decocting 5h, filtering prepared extracts of Chinese herbal medicine；
2) at 25 DEG C, by vaseline, liquid paraffin, candicidin, metronidazole, tanshinone, Nao Sand, realgar, sulphur, dimethyl alum and extracts of Chinese herbal medicine are according to 100:60:24:34:18:7: The weight ratio mixing 30min of 15:8:47:20 prepares candicidin dermatitis ointment A3.
Embodiment 4
Carry out preparing candicidin dermatitis ointment A4 according to the method for embodiment 1, except for the difference that, decocting Before boiling procedure, Chinese herbal medicine is placed in the water of 30 DEG C immersion 28h.
Comparative example 1
Carry out preparing dermatitis ointment B1, except for the difference that, step 2 according to the method for embodiment 1) in do not make Use candicidin.
Comparative example 2
Carry out preparing dermatitis ointment B2, except for the difference that, step 2 according to the method for embodiment 1) in do not make Use extracts of Chinese herbal medicine.
Comparative example 3
Carry out preparing dermatitis ointment B3, except for the difference that, step 2 according to the method for embodiment 1) in do not make Use tanshinone.
Comparative example 4
Carry out preparing dermatitis ointment B4, except for the difference that, step 2 according to the method for embodiment 1) in do not make Use sal ammoniac.
Application examples 1
By above-mentioned dermatitis ointment, 500 example dermatitis and eczema patients are treated, statistics cure rate (%), Cure the healing cycle in patient (my god) and recurrence rate (%) after curing 1 year, concrete outcome is shown in Table 1.
Table 1
Cure rate (%) The healing cycle (my god) Recurrence rate (%)
A1 99.8 14 0.3
A2 99.7 12 0.4
A3 99.6 16 0.5
A4 99.9 15 0.2
B1 78.9 35 9.5
B2 81.2 28 9.3
B3 84.0 26 12.5
B4 79.7 34 11.5
By above-described embodiment and comparative example, the candicidin dermatitis ointment that the present invention provides is to dermatitis Cure rate high, cure that the cycle is short and recurrence rate is low.
The preferred embodiment of the present invention described in detail above, but, the present invention is not limited to above-mentioned reality Execute the detail in mode, in the technology concept of the present invention, can be to the technical side of the present invention Case carries out multiple simple variant, and these simple variant belong to protection scope of the present invention.
It is further to note that each the concrete technology described in above-mentioned detailed description of the invention is special Levy, in the case of reconcilable, can be combined by any suitable means, in order to avoid need not The repetition wanted, various possible combinations are illustrated by the present invention the most separately.
Additionally, can also be combined between the various different embodiment of the present invention, as long as its Without prejudice to the thought of the present invention, it should be considered as content disclosed in this invention equally.

Claims (8)

1. the preparation method of a candicidin dermatitis ointment, it is characterised in that including:
1) carry out Chinese herbal medicine in water decocting, filtering prepared extracts of Chinese herbal medicine；
2) by vaseline, liquid paraffin, candicidin, metronidazole, tanshinone, sal ammoniac, realgar, Sulphur, dimethyl alum and described extracts of Chinese herbal medicine are mixed to prepare candicidin dermatitis ointment；
Wherein, described Chinese herbal medicine contain phlomis umbrosa, Buddha's hand, yncaria stem with hooks, Radix Glycyrrhizae, gecko, Chinese prickly ash, myrobalan, Honeysuckle, the coptis, the root of large-flowered skullcap, golden cypress and cow-bezoar.
Preparation method the most according to claim 1, wherein, in step 1) in, relative to 100 The described phlomis umbrosa of weight portion, the consumption of described Buddha's hand is 37-44 weight portion, and the consumption of described yncaria stem with hooks is 44-65 weight portion, the consumption of described Radix Glycyrrhizae is 10-22 weight portion, and the consumption of described gecko is 55-62 Weight portion, the consumption of described Chinese prickly ash is 34-47 weight portion, and the consumption of described myrobalan is 65-74 weight portion, The consumption of described honeysuckle is 60-84 weight portion, and the consumption of the described coptis is 45-60 weight portion, described The consumption of the root of large-flowered skullcap is 47-58 weight portion, and the consumption of described golden cypress is 33-42 weight portion, described cow-bezoar Consumption is 5-9 weight portion.
Preparation method the most according to claim 2, wherein, described in 100 weight portions Phlomis umbrosa, the consumption of described water is 500-800 weight portion.
4. according to the preparation method described in any one in claim 1-3, wherein, described decoction is extremely Meet following condition less: decocting temperature and be 110-130 DEG C, decocting time is 3-5h.
5. according to the preparation method described in any one in claim 4, wherein, in step 2) in, Relative to the described vaseline of 100 weight portions, the consumption of described liquid paraffin is 47-60 weight portion, institute The consumption stating candicidin is 15-24 weight portion, and the consumption of described metronidazole is 22-34 weight portion, institute The consumption stating tanshinone is 9-18 weight portion, and the consumption of described sal ammoniac is 3-7 weight portion, described realgar Consumption is 8-15 weight portion, and the consumption of described sulphur is 4-8 weight portion, the consumption of described dimethyl alum For 35-47 weight portion, the consumption of described extracts of Chinese herbal medicine is 14-20 weight portion.
6. according to the preparation method described in any one in claim 5, wherein, described decoction it Before, described method also includes that described Chinese herbal medicine is placed in described water soaks.
7. according to the preparation method described in any one in claim 6, wherein, described immersion is at least Meeting following condition: soaking temperature is 25-35 DEG C, soak time is 24-30h.
8. a candicidin dermatitis ointment, it is characterised in that described candicidin dermatitis ointment passes through In 1-7, the method described in any one is prepared.
CN201610363236.0A 2016-05-27 2016-05-27 Candicidin dermatitis ointment and preparing method thereof Pending CN105853561A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1327832A (en) * 2001-06-15 2001-12-26 姜莉蔚 Exterior-applied ointment for treating dermatitis
CN1622820A (en) * 2002-04-15 2005-06-01 山东哲夫 Therapeutic cream for dermatitis
CN1623572A (en) * 2003-12-05 2005-06-08 韩播 Anti-inflammation medicine
CN1679754A (en) * 2005-01-20 2005-10-12 李木林 Strong-effect external-applied preparation for treating multiple skin diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1327832A (en) * 2001-06-15 2001-12-26 姜莉蔚 Exterior-applied ointment for treating dermatitis
CN1622820A (en) * 2002-04-15 2005-06-01 山东哲夫 Therapeutic cream for dermatitis
CN1623572A (en) * 2003-12-05 2005-06-08 韩播 Anti-inflammation medicine
CN1679754A (en) * 2005-01-20 2005-10-12 李木林 Strong-effect external-applied preparation for treating multiple skin diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王宏图 等: "《皮肤科药物手册》", 31 May 2004, 第二军医大学出版社 *

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