CN105853560A - Pimaricin dermatitis ointment and preparation method thereof - Google Patents

Pimaricin dermatitis ointment and preparation method thereof Download PDF

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Publication number
CN105853560A
CN105853560A CN201610361744.5A CN201610361744A CN105853560A CN 105853560 A CN105853560 A CN 105853560A CN 201610361744 A CN201610361744 A CN 201610361744A CN 105853560 A CN105853560 A CN 105853560A
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consumption
weight portion
pimaricin
preparation
dermatitis
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苏福男
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WUHU FOMAN BIOPHARMA Co Ltd
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WUHU FOMAN BIOPHARMA Co Ltd
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Abstract

The invention discloses a pimaricin dermatitis ointment and a preparation method thereof. The preparation method includes the steps that 1, Chinese herbs are decocted with water, decoction is filtered, and Chinese herb extraction liquor is obtained; 2, vaseline, liquid paraffin, pimaricin, metronidazole, tanshinone, sal ammoniac, realgar, sulphur, dimethyl sulfoxide and the Chinese herb extraction liquor are mixed, and the pimaricin dermatitis ointment is prepared, wherein the Chinese herbs include the herb of shady jerusalemsage, nardostachys chinensis Batal, ramulus uncariaecum uncis, licorice roots, geckos, Chinese prickly ash, fructus forsythiae, honeysuckle flowers, radix gentianae macrophyllae, radix scutellariae, cortex phellodendri and calculus bovis. The pimaricin dermatitis ointment prepared with the method is high in cure rate, short in cure period and low in relapse rate on dermatitis.

Description

Pimaricin dermatitis ointment and preparation method thereof
Technical field
The present invention relates to dermatitis ointment, in particular it relates to a kind of pimaricin dermatitis ointment and preparation side thereof Method.
Background technology
Dermatitis and eczema are used to refer to a kind of scytitis frequently as synonym, represent skin for chemistry system The atopic reaction of all materials such as agent, albumen, antibacterial and fungus.The pathogenic factor of dermatitis and eczema is very Complexity, is simply divided into intrinsic factor and extrinsic factor, therebetween difficult point of primary and secondary, it is common that be connected mutually System, synergism；Exopathogenic factor such as chemicals, cosmetics, zootoxin, fish and shrimp, pollen, dust, Exposure to Sunlight and scratching, endogenous cause of ill includes inherited genetic factors, Nervous and Mental Factors, the immune factor of body and metabolic factor Deng.The impact of dermatitis and eczema is increasingly come into one's own by psychological factor, the generation of dermatitis and eczema It is also possible to there is certain relation with diet, rule of life and environment etc..
At present, the medicine of dermatitis and eczema can be divided into Western medicine and Chinese medicine, and the drug effect of Western medicine is fast, but Dermatitis and eczema easily recurs, the drug effect slow-motion of Chinese medicine and cause treatment cycle long, but it is low to control recurrence rate after healing. It can thus be seen that either all there is certain defect in Western medicine or Chinese medicine.
Summary of the invention
It is an object of the invention to provide a kind of pimaricin dermatitis ointment and preparation method thereof, pass through the method The pimaricin dermatitis ointment prepared is high to the cure rate of dermatitis, the healing cycle is short and relapse rate is low.
To achieve these goals, the invention provides the preparation method of a kind of pimaricin dermatitis ointment, Including:
1) carry out Chinese herbal medicine in water decocting, filtering prepared extracts of Chinese herbal medicine；
2) by vaseline, liquid Paraffin, pimaricin, metronidazole, TANSHINONES, Sal Ammoniacus, Realgar, Sulfur, dimethyl sulfoxide and extracts of Chinese herbal medicine are mixed to prepare pimaricin dermatitis ointment；
Wherein, Chinese herbal medicine contains Herba phlomidis, fragrant high, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Gekko Swinhonis, Pericarpium Zanthoxyli, Fructus Forsythiae, gold silver Flower, Radix Gentianae Macrophyllae, Radix Scutellariae, Cortex Phellodendri and Calculus Bovis.
Present invention also offers a kind of pimaricin dermatitis ointment, this pimaricin dermatitis ointment is by above-mentioned Method be prepared.
By technique scheme, the present invention is by each component in above-mentioned preparation method and each step Synergism make that the drug effect of pimaricin dermatitis ointment prepared is fast, cure rate is high, the healing cycle is short and Relapse rate is low, thus overcomes the respective defect of prior art Chinese medicine and western medicine, Chinese medicine, and then improves dermatitis The therapeutic effect of eczema.
Other features and advantages of the present invention will be described in detail in detailed description of the invention part subsequently.
Detailed description of the invention
Hereinafter the detailed description of the invention of the present invention is described in detail.It should be appreciated that this place is retouched The detailed description of the invention stated is merely to illustrate and explains the present invention, is not limited to the present invention.
The invention provides the preparation method of a kind of pimaricin dermatitis ointment, including:
1) carry out Chinese herbal medicine in water decocting, filtering prepared extracts of Chinese herbal medicine；
2) by vaseline, liquid Paraffin, pimaricin, metronidazole, TANSHINONES, Sal Ammoniacus, Realgar, Sulfur, dimethyl sulfoxide and extracts of Chinese herbal medicine are mixed to prepare pimaricin dermatitis ointment；
Wherein, Chinese herbal medicine contains Herba phlomidis, fragrant high, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Gekko Swinhonis, Pericarpium Zanthoxyli, Fructus Forsythiae, gold silver Flower, Radix Gentianae Macrophyllae, Radix Scutellariae, Cortex Phellodendri and Calculus Bovis.
Step 1 in the present invention) in, the consumption of Chinese herbal medicine can select in wide scope, but is Improve the drug effect of pimaricin dermatitis ointment, cure rate, healing cycle and the relapse rate prepared；Preferably Ground, relative to the Herba phlomidis of 100 weight portions, fragrant high consumption is 64-77 weight portion, and the consumption of Ramulus Uncariae Cum Uncis is 44-65 weight portion, the consumption of Radix Glycyrrhizae is 10-22 weight portion, and the consumption of Gekko Swinhonis is 55-62 weight portion, flower The consumption of green pepper is 34-47 weight portion, and the consumption of Fructus Forsythiae is 90-105 weight portion, and the consumption of Flos Lonicerae is 60-84 weight portion, the consumption of Radix Gentianae Macrophyllae is 37-42 weight portion, and the consumption of Radix Scutellariae is 47-58 weight portion, yellow The consumption of cypress is 33-42 weight portion, and the consumption of Calculus Bovis is 5-9 weight portion.
Step 1 in the present invention) in, the consumption of water can select in wide scope, but in order to carry The high drug effect of pimaricin dermatitis ointment, cure rate, healing cycle and the relapse rate prepared；Preferably, Relative to the described Herba phlomidis of 100 weight portions, the consumption of described water is 500-800 weight portion.
Step 1 in the present invention) in, the actual conditions of decoction can select in wide scope, but In order to improve the prepared drug effect of pimaricin dermatitis ointment, cure rate, healing cycle and relapse rate；Excellent Selection of land, decocts and at least meets following condition: decocting temperature and be 110-130 DEG C, decocting time is 3-5h.
Step 2 in the present invention) in, the consumption of each material can select in wide scope, but is Improve the drug effect of pimaricin dermatitis ointment, cure rate, healing cycle and the relapse rate prepared；Preferably Ground, in step 2) in, relative to the vaseline of 100 weight portions, the consumption of liquid Paraffin is 47-60 Weight portion, the consumption of pimaricin is 25-29 weight portion, and the consumption of metronidazole is 22-34 weight portion, The consumption of TANSHINONES is 9-18 weight portion, and the consumption of Sal Ammoniacus is 3-7 weight portion, and the consumption of Realgar is 8-15 Weight portion, the consumption of sulfur is 4-8 weight portion, and the consumption of dimethyl sulfoxide is 35-47 weight portion, in The consumption of medical herbs extracting solution is 30-37 weight portion.
In order to improve further the prepared drug effect of pimaricin dermatitis ointment, cure rate, the healing cycle and Relapse rate, it is preferable that before decocting, the method also includes that Chinese herbal medicine is placed in water soaks.This Sample can improve the extraction ratio of effective ingredient in Chinese herbal medicine as much as possible by the method soaked.
In above-mentioned immersion process, the actual conditions of immersion can select in wide scope, but in order to Improve the drug effect of pimaricin dermatitis ointment, cure rate, healing cycle and the relapse rate prepared；Preferably, Soak and at least meet following condition: soaking temperature is 25-35 DEG C, and soak time is 24-30h.
Present invention also offers a kind of pimaricin dermatitis ointment, this pimaricin dermatitis ointment is by above-mentioned Method be prepared.
Hereinafter will be described the present invention by embodiment.
Embodiment 1
1) by Herba phlomidis, fragrant high, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Gekko Swinhonis, Pericarpium Zanthoxyli, Fructus Forsythiae, Flos Lonicerae, Radix Gentianae Macrophyllae, Radix Scutellariae, Cortex Phellodendri, Calculus Bovis and water are according to 100:69:55:17:59:42:99:74:39:55: Mixed being incorporated at 120 DEG C of the weight ratio of 38:8:700 carries out decocting 4h, filtering prepared extracts of Chinese herbal medicine；
2) at 25 DEG C, by vaseline, liquid Paraffin, pimaricin, metronidazole, TANSHINONES, Nao Sand, Realgar, sulfur, dimethyl sulfoxide and extracts of Chinese herbal medicine are according to 100:50:27:28:14:5: The weight ratio mixing 30min of 12:6:42:35 prepares pimaricin dermatitis ointment A1.
Embodiment 2
1) by Herba phlomidis, fragrant high, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Gekko Swinhonis, Pericarpium Zanthoxyli, Fructus Forsythiae, Flos Lonicerae, Radix Gentianae Macrophyllae, Radix Scutellariae, Cortex Phellodendri, Calculus Bovis and water are according to 100:64:44:10:55:34:90:60:37:47: Mixed being incorporated at 110 DEG C of the weight ratio of 33:5:500 carries out decocting 3h, filtering prepared extracts of Chinese herbal medicine；
2) at 25 DEG C, by vaseline, liquid Paraffin, pimaricin, metronidazole, TANSHINONES, Nao Sand, Realgar, sulfur, dimethyl sulfoxide and extracts of Chinese herbal medicine are according to 100:47:25:22:9:3: The weight ratio mixing 30min of 8:4:35:30 prepares pimaricin dermatitis ointment A2.
Embodiment 3
1) by Herba phlomidis, fragrant high, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Gekko Swinhonis, Pericarpium Zanthoxyli, Fructus Forsythiae, Flos Lonicerae, Radix Gentianae Macrophyllae, Radix Scutellariae, Cortex Phellodendri, Calculus Bovis and water are according to 100:77:65:22:62:47:105:84:42:58: Mixed being incorporated at 130 DEG C of the weight ratio of 42:9:800 carries out decocting 5h, filtering prepared extracts of Chinese herbal medicine；
2) at 25 DEG C, by vaseline, liquid Paraffin, pimaricin, metronidazole, TANSHINONES, Nao Sand, Realgar, sulfur, dimethyl sulfoxide and extracts of Chinese herbal medicine are according to 100:60:29:34:18:7: The weight ratio mixing 30min of 15:8:47:37 prepares pimaricin dermatitis ointment A3.
Embodiment 4
Carry out preparing pimaricin dermatitis ointment A4 according to the method for embodiment 1, except for the difference that, decocting Before boiling procedure, Chinese herbal medicine is placed in the water of 30 DEG C immersion 28h.
Comparative example 1
Carry out preparing dermatitis ointment B1, except for the difference that, step 2 according to the method for embodiment 1) in do not make Use pimaricin.
Comparative example 2
Carry out preparing dermatitis ointment B2, except for the difference that, step 2 according to the method for embodiment 1) in do not make Use extracts of Chinese herbal medicine.
Comparative example 3
Carry out preparing dermatitis ointment B3, except for the difference that, step 2 according to the method for embodiment 1) in do not make Use TANSHINONES.
Comparative example 4
Carry out preparing dermatitis ointment B4, except for the difference that, step 2 according to the method for embodiment 1) in do not make Use Sal Ammoniacus.
Application examples 1
By above-mentioned dermatitis ointment, 500 example dermatitis and eczema patients are treated, statistics cure rate (%), Cure the healing cycle in patient (my god) and relapse rate (%) after curing 1 year, concrete outcome is shown in Table 1.
Table 1
Cure rate (%) The healing cycle (my god) Relapse rate (%)
A1 99.6 14 0.5
A2 99.5 13 0.4
A3 99.6 16 0.6
A4 99.8 14 0.2
B1 78.5 35 9.9
B2 81.7 28 9.5
B3 84.3 25 10.3
B4 79.8 31 11.1
By above-described embodiment and comparative example, the pimaricin dermatitis ointment that the present invention provides is to dermatitis Cure rate high, cure that the cycle is short and relapse rate is low.
The preferred embodiment of the present invention described in detail above, but, the present invention is not limited to above-mentioned reality Execute the detail in mode, in the technology concept of the present invention, can be to the technical side of the present invention Case carries out multiple simple variant, and these simple variant belong to protection scope of the present invention.
It is further to note that each the concrete technology described in above-mentioned detailed description of the invention is special Levy, in the case of reconcilable, can be combined by any suitable means, in order to avoid need not The repetition wanted, various possible compound modes are illustrated by the present invention the most separately.
Additionally, combination in any can also be carried out between the various different embodiment of the present invention, as long as its Without prejudice to the thought of the present invention, it should be considered as content disclosed in this invention equally.

Claims (8)

1. the preparation method of a pimaricin dermatitis ointment, it is characterised in that including:
1) carry out Chinese herbal medicine in water decocting, filtering prepared extracts of Chinese herbal medicine；
2) by vaseline, liquid Paraffin, pimaricin, metronidazole, TANSHINONES, Sal Ammoniacus, Realgar, Sulfur, dimethyl sulfoxide and described extracts of Chinese herbal medicine are mixed to prepare pimaricin dermatitis ointment；
Wherein, described Chinese herbal medicine contain Herba phlomidis, fragrant high, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Gekko Swinhonis, Pericarpium Zanthoxyli, Fructus Forsythiae, Flos Lonicerae, Radix Gentianae Macrophyllae, Radix Scutellariae, Cortex Phellodendri and Calculus Bovis.
Preparation method the most according to claim 1, wherein, in step 1) in, relative to 100 The described Herba phlomidis of weight portion, the high consumption of described perfume (or spice) is 64-77 weight portion, and the consumption of described Ramulus Uncariae Cum Uncis is 44-65 weight portion, the consumption of described Radix Glycyrrhizae is 10-22 weight portion, and the consumption of described Gekko Swinhonis is 55-62 Weight portion, the consumption of described Pericarpium Zanthoxyli is 34-47 weight portion, and the consumption of described Fructus Forsythiae is 90-105 weight portion, The consumption of described Flos Lonicerae is 60-84 weight portion, and the consumption of described Radix Gentianae Macrophyllae is 37-42 weight portion, described The consumption of Radix Scutellariae is 47-58 weight portion, and the consumption of described Cortex Phellodendri is 33-42 weight portion, described Calculus Bovis Consumption is 5-9 weight portion.
Preparation method the most according to claim 2, wherein, described in 100 weight portions Herba phlomidis, the consumption of described water is 500-800 weight portion.
4. according to the preparation method described in any one in claim 1-3, wherein, described decoction is extremely Meet following condition less: decocting temperature and be 110-130 DEG C, decocting time is 3-5h.
5. according to the preparation method described in any one in claim 4, wherein, in step 2) in, Relative to the described vaseline of 100 weight portions, the consumption of described liquid Paraffin is 47-60 weight portion, institute The consumption stating pimaricin is 25-29 weight portion, and the consumption of described metronidazole is 22-34 weight portion, institute The consumption stating TANSHINONES is 9-18 weight portion, and the consumption of described Sal Ammoniacus is 3-7 weight portion, described Realgar Consumption is 8-15 weight portion, and the consumption of described sulfur is 4-8 weight portion, the consumption of described dimethyl sulfoxide For 35-47 weight portion, the consumption of described extracts of Chinese herbal medicine is 30-37 weight portion.
6. according to the preparation method described in any one in claim 5, wherein, described decoction it Before, described method also includes that described Chinese herbal medicine is placed in described water soaks.
7. according to the preparation method described in any one in claim 6, wherein, described immersion is at least Meeting following condition: soaking temperature is 25-35 DEG C, soak time is 24-30h.
8. a pimaricin dermatitis ointment, it is characterised in that described pimaricin dermatitis ointment passes through In 1-7, the method described in any one is prepared.
CN201610361744.5A 2016-05-27 2016-05-27 Pimaricin dermatitis ointment and preparation method thereof Pending CN105853560A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1327832A (en) * 2001-06-15 2001-12-26 姜莉蔚 Exterior-applied ointment for treating dermatitis
CN1622820A (en) * 2002-04-15 2005-06-01 山东哲夫 Therapeutic cream for dermatitis
CN1623572A (en) * 2003-12-05 2005-06-08 韩播 Anti-inflammation medicine
CN1679754A (en) * 2005-01-20 2005-10-12 李木林 Strong-effect external-applied preparation for treating multiple skin diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1327832A (en) * 2001-06-15 2001-12-26 姜莉蔚 Exterior-applied ointment for treating dermatitis
CN1622820A (en) * 2002-04-15 2005-06-01 山东哲夫 Therapeutic cream for dermatitis
CN1623572A (en) * 2003-12-05 2005-06-08 韩播 Anti-inflammation medicine
CN1679754A (en) * 2005-01-20 2005-10-12 李木林 Strong-effect external-applied preparation for treating multiple skin diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王宏图 等: "《皮肤科药物手册》", 31 May 2004, 第二军医大学出版社 *

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