CN105998308A - Nystatin dermatitis ointment and preparation method thereof - Google Patents

Nystatin dermatitis ointment and preparation method thereof Download PDF

Info

Publication number
CN105998308A
CN105998308A CN201610362911.8A CN201610362911A CN105998308A CN 105998308 A CN105998308 A CN 105998308A CN 201610362911 A CN201610362911 A CN 201610362911A CN 105998308 A CN105998308 A CN 105998308A
Authority
CN
China
Prior art keywords
consumption
weight portion
nystatin
chinese herbal
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610362911.8A
Other languages
Chinese (zh)
Inventor
苏福男
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WUHU FOMAN BIOPHARMA Co Ltd
Original Assignee
WUHU FOMAN BIOPHARMA Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WUHU FOMAN BIOPHARMA Co Ltd filed Critical WUHU FOMAN BIOPHARMA Co Ltd
Priority to CN201610362911.8A priority Critical patent/CN105998308A/en
Publication of CN105998308A publication Critical patent/CN105998308A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/36—Arsenic; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A61K35/04—Tars; Bitumens; Mineral oils; Ammonium bituminosulfonate
    • A61K35/06—Mineral oils, e.g. paraffinic oils or aromatic oils based on aromatic hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/413—Gall bladder; Bile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/583—Snakes; Lizards, e.g. chameleons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention discloses nystatin dermatitis ointment and a preparation method thereof. The preparation method comprises the steps: (1) decocting Chinese herbal medicines in water and filtering, thereby preparing a Chinese herbal medicine extracting solution; (2) mixing vaseline, liquid paraffin, nystatin, metronidazole, tanshinone, sal ammoniac, realgar, sulfur, dimethyl sulfoxide and the Chinese herbal medicine extracting solution, thereby preparing the nystatin dermatitis ointment, wherein the Chinese herbal medicines comprise phlomis umbrosa, the bark of ash, uncaria, radix glycyrrhizae, wall lizard, Chinese prickly ash, phillyrin, honeysuckle, coptidis rhizome, radix scutellariae, radix platycodi and calculus bovis. By utilizing the nystatin dermatitis ointment prepared by the preparation method provided by the invention to cure dermatitis, the cure rate is high, the cure cycle is short, and the recurrence rate is low.

Description

Nystatin dermatitis ointment and preparation method thereof
Technical field
The present invention relates to dermatitis ointment, in particular it relates to a kind of nystatin dermatitis ointment and preparation side thereof Method.
Background technology
Dermatitis and eczema are used to refer to a kind of scytitis frequently as synonym, represent skin for chemistry system The atopic reaction of all materials such as agent, albumen, antibacterial and fungus.The pathogenic factor of dermatitis and eczema is very Complexity, is simply divided into intrinsic factor and extrinsic factor, therebetween difficult point of primary and secondary, it is common that be connected mutually System, synergism；Exopathogenic factor such as chemicals, cosmetics, zootoxin, fish and shrimp, pollen, dust, Exposure to Sunlight and scratching, endogenous cause of ill includes inherited genetic factors, Nervous and Mental Factors, the immune factor of body and metabolic factor Deng.The impact of dermatitis and eczema is increasingly come into one's own by psychological factor, the generation of dermatitis and eczema It is also possible to there is certain relation with diet, rule of life and environment etc..
At present, the medicine of dermatitis and eczema can be divided into Western medicine and Chinese medicine, and the drug effect of Western medicine is fast, but Dermatitis and eczema easily recurs, the drug effect slow-motion of Chinese medicine and cause treatment cycle long, but it is low to control recurrence rate after healing. It can thus be seen that either all there is certain defect in Western medicine or Chinese medicine.
Summary of the invention
It is an object of the invention to provide a kind of nystatin dermatitis ointment and preparation method thereof, pass through the method The nystatin dermatitis ointment prepared is high to the cure rate of dermatitis, the healing cycle is short and relapse rate is low.
To achieve these goals, the invention provides the preparation method of a kind of nystatin dermatitis ointment, Including:
1) carry out Chinese herbal medicine in water decocting, filtering prepared extracts of Chinese herbal medicine；
2) by vaseline, liquid Paraffin, nystatin, metronidazole, TANSHINONES, Sal Ammoniacus, Realgar, Sulfur, dimethyl sulfoxide and extracts of Chinese herbal medicine are mixed to prepare nystatin dermatitis ointment；
Wherein, Chinese herbal medicine contains Herba phlomidis, Cortex Fraxini, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Gekko Swinhonis, Pericarpium Zanthoxyli, Fructus Forsythiae, gold silver Flower, Rhizoma Coptidis, Radix Scutellariae, Radix Platycodonis and Calculus Bovis.
Present invention also offers a kind of nystatin dermatitis ointment, this nystatin dermatitis ointment is by above-mentioned Method be prepared.
By technique scheme, the present invention is by each component in above-mentioned preparation method and each step Synergism make that the drug effect of nystatin dermatitis ointment prepared is fast, cure rate is high, the healing cycle is short and Relapse rate is low, thus overcomes the respective defect of prior art Chinese medicine and western medicine, Chinese medicine, and then improves dermatitis The therapeutic effect of eczema.
Other features and advantages of the present invention will be described in detail in detailed description of the invention part subsequently.
Detailed description of the invention
Hereinafter the detailed description of the invention of the present invention is described in detail.It should be appreciated that this place is retouched The detailed description of the invention stated is merely to illustrate and explains the present invention, is not limited to the present invention.
The invention provides the preparation method of a kind of nystatin dermatitis ointment, including:
1) carry out Chinese herbal medicine in water decocting, filtering prepared extracts of Chinese herbal medicine；
2) by vaseline, liquid Paraffin, nystatin, metronidazole, TANSHINONES, Sal Ammoniacus, Realgar, Sulfur, dimethyl sulfoxide and extracts of Chinese herbal medicine are mixed to prepare nystatin dermatitis ointment；
Wherein, Chinese herbal medicine contains Herba phlomidis, Cortex Fraxini, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Gekko Swinhonis, Pericarpium Zanthoxyli, Fructus Forsythiae, gold silver Flower, Rhizoma Coptidis, Radix Scutellariae, Radix Platycodonis and Calculus Bovis.
Step 1 in the present invention) in, the consumption of Chinese herbal medicine can select in wide scope, but is Improve the drug effect of nystatin dermatitis ointment, cure rate, healing cycle and the relapse rate prepared；Preferably Ground, relative to the Herba phlomidis of 100 weight portions, the consumption of Cortex Fraxini is 52-61 weight portion, and the consumption of Ramulus Uncariae Cum Uncis is 44-65 weight portion, the consumption of Radix Glycyrrhizae is 10-22 weight portion, and the consumption of Gekko Swinhonis is 55-62 weight portion, flower The consumption of green pepper is 34-47 weight portion, and the consumption of Fructus Forsythiae is 90-105 weight portion, and the consumption of Flos Lonicerae is 60-84 weight portion, the consumption of Rhizoma Coptidis is 45-60 weight portion, and the consumption of Radix Scutellariae is 47-58 weight portion, Fructus Citri tangerinae The consumption of stalk is 44-52 weight portion, and the consumption of Calculus Bovis is 5-9 weight portion.
Step 1 in the present invention) in, the consumption of water can select in wide scope, but in order to carry The high drug effect of nystatin dermatitis ointment, cure rate, healing cycle and the relapse rate prepared；Preferably, Relative to the described Herba phlomidis of 100 weight portions, the consumption of described water is 500-800 weight portion.
Step 1 in the present invention) in, the actual conditions of decoction can select in wide scope, but In order to improve the prepared drug effect of nystatin dermatitis ointment, cure rate, healing cycle and relapse rate；Excellent Selection of land, decocts and at least meets following condition: decocting temperature and be 110-130 DEG C, decocting time is 3-5h.
Step 2 in the present invention) in, the consumption of each material can select in wide scope, but is Improve the drug effect of nystatin dermatitis ointment, cure rate, healing cycle and the relapse rate prepared；Preferably Ground, in step 2) in, relative to the vaseline of 100 weight portions, the consumption of liquid Paraffin is 47-60 Weight portion, the consumption of nystatin is 30-34 weight portion, and the consumption of metronidazole is 22-34 weight portion, The consumption of TANSHINONES is 9-18 weight portion, and the consumption of Sal Ammoniacus is 3-7 weight portion, and the consumption of Realgar is 8-15 Weight portion, the consumption of sulfur is 4-8 weight portion, and the consumption of dimethyl sulfoxide is 35-47 weight portion, in The consumption of medical herbs extracting solution is 30-36 weight portion.
In order to improve further the prepared drug effect of nystatin dermatitis ointment, cure rate, the healing cycle and Relapse rate, it is preferable that before decocting, the method also includes that Chinese herbal medicine is placed in water soaks.This Sample can improve the extraction ratio of effective ingredient in Chinese herbal medicine as much as possible by the method soaked.
In above-mentioned immersion process, the actual conditions of immersion can select in wide scope, but in order to Improve the drug effect of nystatin dermatitis ointment, cure rate, healing cycle and the relapse rate prepared；Preferably, Soak and at least meet following condition: soaking temperature is 25-35 DEG C, and soak time is 24-30h.
Present invention also offers a kind of nystatin dermatitis ointment, this nystatin dermatitis ointment is by above-mentioned Method be prepared.
Hereinafter will be described the present invention by embodiment.
Embodiment 1
1) by Herba phlomidis, Cortex Fraxini, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Gekko Swinhonis, Pericarpium Zanthoxyli, Fructus Forsythiae, Flos Lonicerae, Rhizoma Coptidis, Radix Scutellariae, Radix Platycodonis, Calculus Bovis and water are according to 100:57:49:15:58:41:97:74:55:53: Mixed being incorporated at 120 DEG C of the weight ratio of 47:7:700 carries out decocting 4h, filtering prepared extracts of Chinese herbal medicine；
2) at 25 DEG C, by vaseline, liquid Paraffin, nystatin, metronidazole, TANSHINONES, Nao Sand, Realgar, sulfur, dimethyl sulfoxide and extracts of Chinese herbal medicine are according to 100:50:32:28:12:5: The weight ratio mixing 30min of 10:6:39:33 prepares nystatin dermatitis ointment A1.
Embodiment 2
1) by Herba phlomidis, Cortex Fraxini, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Gekko Swinhonis, Pericarpium Zanthoxyli, Fructus Forsythiae, Flos Lonicerae, Rhizoma Coptidis, Radix Scutellariae, Radix Platycodonis, Calculus Bovis and water are according to 100:52:44:10:55:34:90:60:45:47: Mixed being incorporated at 110 DEG C of the weight ratio of 44:5:500 carries out decocting 3h, filtering prepared extracts of Chinese herbal medicine；
2) at 25 DEG C, by vaseline, liquid Paraffin, nystatin, metronidazole, TANSHINONES, Nao Sand, Realgar, sulfur, dimethyl sulfoxide and extracts of Chinese herbal medicine are according to 100:47:30:22:9:3: The weight ratio mixing 30min of 8:4:35:30 prepares nystatin dermatitis ointment A2.
Embodiment 3
1) by Herba phlomidis, Cortex Fraxini, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Gekko Swinhonis, Pericarpium Zanthoxyli, Fructus Forsythiae, Flos Lonicerae, Rhizoma Coptidis, Radix Scutellariae, Radix Platycodonis, Calculus Bovis and water are according to 100:61:65:22:62:47:105:84:60:58: Mixed being incorporated at 130 DEG C of the weight ratio of 52:9:800 carries out decocting 5h, filtering prepared extracts of Chinese herbal medicine；
2) at 25 DEG C, by vaseline, liquid Paraffin, nystatin, metronidazole, TANSHINONES, Nao Sand, Realgar, sulfur, dimethyl sulfoxide and extracts of Chinese herbal medicine are according to 100:60:34:34:18:7: The weight ratio mixing 30min of 15:8:47:36 prepares nystatin dermatitis ointment A3.
Embodiment 4
Carry out preparing nystatin dermatitis ointment A4 according to the method for embodiment 1, except for the difference that, decocting Before boiling procedure, Chinese herbal medicine is placed in the water of 30 DEG C immersion 28h.
Comparative example 1
Carry out preparing dermatitis ointment B1, except for the difference that, step 2 according to the method for embodiment 1) in do not make Use nystatin.
Comparative example 2
Carry out preparing dermatitis ointment B2, except for the difference that, step 2 according to the method for embodiment 1) in do not make Use extracts of Chinese herbal medicine.
Comparative example 3
Carry out preparing dermatitis ointment B3, except for the difference that, step 2 according to the method for embodiment 1) in do not make Use TANSHINONES.
Comparative example 4
Carry out preparing dermatitis ointment B4, except for the difference that, step 2 according to the method for embodiment 1) in do not make Use Sal Ammoniacus.
Application examples 1
By above-mentioned dermatitis ointment, 500 example dermatitis and eczema patients are treated, statistics cure rate (%), Cure the healing cycle in patient (my god) and relapse rate (%) after curing 1 year, concrete outcome is shown in Table 1.
Table 1
Cure rate (%) The healing cycle (my god) Relapse rate (%)
A1 99.6 15 0.5
A2 99.5 13 0.4
A3 99.7 14 0.3
A4 99.8 12 0.2
B1 78.4 37 9.7
B2 81.9 29 9.0
B3 84.0 24 10.4
B4 79.2 31 11.3
By above-described embodiment and comparative example, the nystatin dermatitis ointment that the present invention provides is to dermatitis Cure rate high, cure that the cycle is short and relapse rate is low.
The preferred embodiment of the present invention described in detail above, but, the present invention is not limited to above-mentioned reality Execute the detail in mode, in the technology concept of the present invention, can be to the technical side of the present invention Case carries out multiple simple variant, and these simple variant belong to protection scope of the present invention.
It is further to note that each the concrete technology described in above-mentioned detailed description of the invention is special Levy, in the case of reconcilable, can be combined by any suitable means, in order to avoid need not The repetition wanted, various possible compound modes are illustrated by the present invention the most separately.
Additionally, combination in any can also be carried out between the various different embodiment of the present invention, as long as its Without prejudice to the thought of the present invention, it should be considered as content disclosed in this invention equally.

Claims (8)

1. the preparation method of a nystatin dermatitis ointment, it is characterised in that including:
1) carry out Chinese herbal medicine in water decocting, filtering prepared extracts of Chinese herbal medicine；
2) by vaseline, liquid Paraffin, nystatin, metronidazole, TANSHINONES, Sal Ammoniacus, Realgar, Sulfur, dimethyl sulfoxide and described extracts of Chinese herbal medicine are mixed to prepare nystatin dermatitis ointment；
Wherein, described Chinese herbal medicine contain Herba phlomidis, Cortex Fraxini, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Gekko Swinhonis, Pericarpium Zanthoxyli, Fructus Forsythiae, Flos Lonicerae, Rhizoma Coptidis, Radix Scutellariae, Radix Platycodonis and Calculus Bovis.
Preparation method the most according to claim 1, wherein, in step 1) in, relative to 100 The described Herba phlomidis of weight portion, the consumption of described Cortex Fraxini is 52-61 weight portion, and the consumption of described Ramulus Uncariae Cum Uncis is 44-65 weight portion, the consumption of described Radix Glycyrrhizae is 10-22 weight portion, and the consumption of described Gekko Swinhonis is 55-62 Weight portion, the consumption of described Pericarpium Zanthoxyli is 34-47 weight portion, and the consumption of described Fructus Forsythiae is 90-105 weight portion, The consumption of described Flos Lonicerae is 60-84 weight portion, and the consumption of described Rhizoma Coptidis is 45-60 weight portion, described The consumption of Radix Scutellariae is 47-58 weight portion, and the consumption of described Radix Platycodonis is 44-52 weight portion, described Calculus Bovis Consumption is 5-9 weight portion.
Preparation method the most according to claim 2, wherein, described in 100 weight portions Herba phlomidis, the consumption of described water is 500-800 weight portion.
4. according to the preparation method described in any one in claim 1-3, wherein, described decoction is extremely Meet following condition less: decocting temperature and be 110-130 DEG C, decocting time is 3-5h.
5. according to the preparation method described in any one in claim 4, wherein, in step 2) in, Relative to the described vaseline of 100 weight portions, the consumption of described liquid Paraffin is 47-60 weight portion, institute The consumption stating nystatin is 30-34 weight portion, and the consumption of described metronidazole is 22-34 weight portion, institute The consumption stating TANSHINONES is 9-18 weight portion, and the consumption of described Sal Ammoniacus is 3-7 weight portion, described Realgar Consumption is 8-15 weight portion, and the consumption of described sulfur is 4-8 weight portion, the consumption of described dimethyl sulfoxide For 35-47 weight portion, the consumption of described extracts of Chinese herbal medicine is 30-36 weight portion.
6. according to the preparation method described in any one in claim 5, wherein, described decoction it Before, described method also includes that described Chinese herbal medicine is placed in described water soaks.
7. according to the preparation method described in any one in claim 6, wherein, described immersion is at least Meeting following condition: soaking temperature is 25-35 DEG C, soak time is 24-30h.
8. a nystatin dermatitis ointment, it is characterised in that described nystatin dermatitis ointment passes through In 1-7, the method described in any one is prepared.
CN201610362911.8A 2016-05-27 2016-05-27 Nystatin dermatitis ointment and preparation method thereof Pending CN105998308A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610362911.8A CN105998308A (en) 2016-05-27 2016-05-27 Nystatin dermatitis ointment and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610362911.8A CN105998308A (en) 2016-05-27 2016-05-27 Nystatin dermatitis ointment and preparation method thereof

Publications (1)

Publication Number Publication Date
CN105998308A true CN105998308A (en) 2016-10-12

Family

ID=57094192

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610362911.8A Pending CN105998308A (en) 2016-05-27 2016-05-27 Nystatin dermatitis ointment and preparation method thereof

Country Status (1)

Country Link
CN (1) CN105998308A (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1327832A (en) * 2001-06-15 2001-12-26 姜莉蔚 Exterior-applied ointment for treating dermatitis
CN1622820A (en) * 2002-04-15 2005-06-01 山东哲夫 Therapeutic cream for dermatitis
CN1623572A (en) * 2003-12-05 2005-06-08 韩播 Anti-inflammation medicine
CN1679754A (en) * 2005-01-20 2005-10-12 李木林 Strong-effect external-applied preparation for treating multiple skin diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1327832A (en) * 2001-06-15 2001-12-26 姜莉蔚 Exterior-applied ointment for treating dermatitis
CN1622820A (en) * 2002-04-15 2005-06-01 山东哲夫 Therapeutic cream for dermatitis
CN1623572A (en) * 2003-12-05 2005-06-08 韩播 Anti-inflammation medicine
CN1679754A (en) * 2005-01-20 2005-10-12 李木林 Strong-effect external-applied preparation for treating multiple skin diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
邓家刚: "《中药新家族-化学中药》", 30 September 2008, 中国中医药出版社 *

Similar Documents

Publication Publication Date Title
CN102178809B (en) Externally-applied medicament for skin and method for processing medicament into preparation
CN105998980A (en) Anti-virus traditional Chinese medicinal composition and preparation method thereof
CN1315457C (en) Bath liquid used for frostbite nursing and its preparation method
CN102000155A (en) Medicated wine with effect of promoting blood circulation and removing blood stasis
CN104435686A (en) Use of traditional Chinese medicine preparation in preparation of medicine for treating skin itch and eczema papulosum
CN105920183A (en) Abamectin dermatitis ointment and preparation method thereof
CN105232824A (en) Tea oil composition and preparing method and application thereof
CN105213584A (en) A kind of Chinese medicine composition for the treatment of eczema and preparation method thereof
CN105079417A (en) Ointment for treating skin itching and preparation method thereof
CN105998308A (en) Nystatin dermatitis ointment and preparation method thereof
CN103989975A (en) Traditional Chinese medicine preparation for the treatment of hepatitis b
CN107411464A (en) A kind of health care's medicine-filled pillow and preparation method thereof
CN105853560A (en) Pimaricin dermatitis ointment and preparation method thereof
CN105853561A (en) Candicidin dermatitis ointment and preparing method thereof
CN105878579A (en) Gibberellin dermatitis ointment and preparation method thereof
CN103417783A (en) TCM seaweed mask for treatment of facial steroid corticosteroid dependent dermatitis
CN105769628A (en) Itching relieving liquid shampoo
CN104069421A (en) Traditional Chinese medicine composition for treating heart diseases
CN106334112A (en) Traditional Chinese medicine bath-taking powder for treating spontaneous perspiration disease, and preparation method thereof
CN106137844A (en) A kind of infant diaper ointment and preparation method thereof
CN108478688A (en) Dermatitis ointment and preparation method thereof
CN108478735A (en) Chinese herbal medicine dermatitis ointment and preparation method thereof
CN106361843A (en) Traditional Chinese medicine and preparing method thereof
CN104398893B (en) Compound traditional Chinese medicinal ointment for treating acute eczema and preparation method thereof
CN108310177A (en) Chinese herbal medicine dermatitis ointment and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20161012

RJ01 Rejection of invention patent application after publication